In a previous transactivation screen, two Arabidopsis thaliana R2R3-MYB transcription factors, HAG2/MYB76 and HAG3/MYB29, along with the already characterized HAG1/MYB28, were identified as putative regulators of aliphatic glucosinolate biosynthesis. Molecular and biochemical characterization of HAG2/MYB76 and HAG3/MYB29 functions was performed using transformants with increased or repressed transcript levels. Real-time PCR assays, cotransformation assays and measurements of glucosinolate contents were used to assess the impact of both MYB factors on the steady-state level of glucosinolate biosynthetic genes and accumulation of aliphatic glucosinolates. Both HAG2/MYB76 and HAG3/MYB29 were shown to be positive regulators of aliphatic glucosinolate biosynthesis. Expression of promoter-beta-glucuronidase (GUS) fusions indicated GUS activities in both vegetative and generative organs, with distinct characteristics for each MYB factor. HAG1/MYB28, HAG2/MYB76 and HAG3/MYB29 reciprocally transactivated ...
Glucosinolates are Brassicaceae-specific secondary metabolites that act as crop protectants, flavor precursors and cancer-prevention agents, which shows strong evidences of anticarcinogentic, antioxidant and antimicrobial activities. MYB28, the R2R3-MYB28 transcription factor, directly activates genes involved in aliphatic glucosinolate biosynthesis. In this study, the MYB28 homology (BoaMYB28) was identified in Chinese kale (Brassica oleracea var. alboglabra Bailey). Analysis of the nucleotide sequence indicated that the cDNA of BoaMYB28 was 1257 bp with an ORF of 1020 bp. The deduced BoaMYB28 protein was a polypeptide of 339 amino acid with a putative molecular mass of 38 kDa and a pI of 6.87. Sequence homology and phylogenetic analysis showed that BoaMYB28 was most closely related to MYB28 homologs from the Brassicaceae family. The expression levels of BoaMYB28 varies across the tissues and developmental stages. BoaMYB28 transcript levels were higher in leaves and stems compared with those in
Glucosinolates are plant secondary metabolites present in Brassicaceae plants such as the model plant Arabidopsis thaliana. Intact glucosinolates are believed to be biologically inactive, whereas degradation products after hydrolysis have multiple roles in growth regulation and defense. The degradation of glucosinolates is catalyzed by thioglucosidases called myrosinases and leads by default to the formation of isothiocyanates. The interaction of a protein called epithiospecifier protein (ESP) with myrosinase diverts the reaction toward the production of epithionitriles or nitriles depending on the glucosinolate structure. Here we report the identification of a new group of nitrile-specifier proteins (AtNSPs) in A. thaliana able to generate nitriles in conjunction with myrosinase and a more detailed characterization of one member (AtNSP2). Recombinant AtNSP2 expressed in Escherichia coli was used to test its impact on the outcome of glucosinolate hydrolysis using a gas chromatography-mass ...
Within the cell, biosynthetic pathways are embedded in protein-protein interaction networks. In Arabidopsis, the biosynthetic pathways of aliphatic and indole glucosinolate defense compounds are well-characterized. However, little is known about the spatial orchestration of these enzymes and their interplay with the cellular environment. To address these aspects, we applied two complementary, untargeted approaches - split-ubiquitin yeast 2-hybrid and co-immunoprecipitation screens - to identify proteins interacting with CYP83A1 and CYP83B1, two homologous enzymes specific for aliphatic and indole glucosinolate biosynthesis, respectively. Our analyses reveal distinct functional networks with substantial interconnection among the identified interactors for both pathway-specific markers, and add to our knowledge about how biochemical pathways are connected to cellular processes. Specifically, a group of protein interactors involved in cell death and the hypersensitive response provides a potential link
Glucosinolates are plant secondary metabolites composed of a thioglucose group and an amino acid side-chain. They occur in the Brassicaceae and related families. A wide variety of glucosinolates exists owing to modification of the side-chain structure. Following tissue damage, myrosinase enzymes catalyse the decomposition of glucosinolates to a variety of volatile and nonvolatile products. The genetic control of concentration and side-chain modification of aliphatic glucosinolates, which have side-chains derived from methionine, are simple and well known from work on Arabidopsis and Brassica crops. In controlled conditions in the laboratory or in field trials, many aliphatic glucosinolates, or their degradation products, affect the behaviour of herbivores. For these reasons, we suggest that polymorphism for aliphatic glucosinolates in natural populations offers an attractive system for the study of ecological genetics of plant-herbivore interactions.
The purpose of the present study was to evaluate the in vitro antibacterial effects of different classes of important and common dietary phytochemicals (5 simple phenolics - tyrosol, gallic acid, caffeic acid, ferulic acid, and chlorogenic acid; chalcone - phloridzin; flavan-3-ol - (-) epicatechin; seco-iridoid - oleuropein glucoside; 3 glucosinolate hydrolysis products - allylisothiocyanate, benzylisothiocyanate and 2-phenylethylisothiocyanate) against Escherichia coli, Pseudomonas aeruginosa, Listeria monocytogenes and Staphylococcus aureus. Another objective of this study was to evaluate the effects of dual combinations of streptomycin with the different phytochemicals on antibacterial activity. A disc diffusion assay was used to evaluate the antibacterial activity of the phytochemicals and 3 standard antibiotics (ciprofloxacin, gentamicin and streptomycin) against the four bacteria. The antimicrobial activity of single compounds and dual combinations (streptomycin-phytochemicals) were ...
Glucosinolates are a class of plant secondary metabolites of Brassicaceaefamily with diverse biological functions. Hydrolytic products of some glucosinolates are beneficial whereas some impart...
Author: Knill, T. et al.; Genre: Journal Article; Published in Print: 2008; Open Access; Title: Arabidopsis Branched-Chain Aminotransferase 3 Functions in Both Amino Acid and Glucosinolate Biosynthesis
In previous clinical studies, we evaluated the metabolism and disposition of glucosinolates and isothiocyanates in a variety of crucifers, including market stage broccoli (11) . The current studies focus entirely on broccoli sprouts, which differ from mature broccoli plants in two important aspects (9 , 13 , 25) : (a) on a gram-fresh-weight basis, they contain up to 50 times more glucoraphanin, the glucosinolate precursor of sulforaphane, which is the most potent natural phase 2 enzyme-inducer known. Second, they contain substantially less or no detectable amounts of the indole and β-hydroxyalkenyl glucosinolates that are associated with potential toxicities (Table 1⇓ and Fig. 3⇓ ).. The principal end point in these studies was urinary dithiocarbamate excretion, as measured by the cyclocondensation reaction. Although this assay detects with equal efficiency isothiocyanates and each of the sequential metabolites (Fig. 1B)⇓ , the available evidence indicates that urine contains no ...
Influence of the lime on inorganic ion and glucosinolate contents in Chinese cabbage - Calcium;Chinese cabbage;Inorganic ion;Glucosinolates;Slaked lime;
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Cruciferous vegetables differ from other classes of vegetables in that they are rich sources of sulfur-containing compounds known as glucosinolates (see Cruciferous Vegetables). Because epidemiological studies provide some evidence that diets rich in cruciferous vegetables are associated with lower risk of several types of cancer, scientists are interested in the potential cancer-preventive activities of compounds derived from glucosinolates (1). Among these compounds is indole-3-carbinol (I3C), a compound derived from the enzymatic hydrolysis (breakdown) of an indole glucosinolate, commonly known as glucobrassicin (2).. Summary. * Indole-3-carbinol (I3C) is derived from the hydrolysis (breakdown) of glucobrassicin, a compound found in cruciferous vegetables. * In the acidic environment of the stomach, I3C molecules can combine with each other to form a number of biologically active acid condensation products, such as 3,3-diindolylmethane (DIM). * I3C has been found to inhibit the development ...
Glucosinolates are a group of sulfur-containing glycosides found in many plant species, including cruciferous vegetables such as broccoli, cabbage, brussels sprouts, and cauliflower. Accumulating evidence increasingly supports the beneficial effects of dietary glucosinolates on overall health, including as potential anti-cancer agents, because of their role in the prevention of the initiation of carcinogenesis via the induction of cellular defense detoxifying/antioxidant enzymes and their epigenetic mechanisms, including modification of the CpG methylation of cancer-related genes, histone modification regulation and changes in the expression of miRNAs. In this context, the defense mechanism mediated by Nrf2-antioxidative stress and anti-inflammatory signaling pathways can contribute to cellular protection against oxidative stress and reactive metabolites of carcinogens. In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of ...
Glucosinolates are the major class of secondary metabolites found in Brassicacrops. The molecule comprises a β-thioglucose moiety, a sulphonated oxime moiety and a variable side chain, derived from...
The aim of this study is to examine the effects of a diet rich in broccoli on cardiovascular disease risk using biochemical indicators such as blood lipid profiles, most notably cholesterol; markers of inflammation as well as established physiological measurements such as Pulse wave velocity (PWV), Augmentation index (AIx) and Ambulatory Blood Pressure Measurements (ABPM). Broccoli contains compounds known as glucosinolates which are metabolised to isothiocyanates when consumed. The major glucosinolate in broccoli is known as glucoraphanin which produces the isothiocyanate sulforaphane. The glucosinolates are thought to be the principal component in broccoli that may reduce CVD risk. The investigators will use a standard cultivar of broccoli and a cultivar that has enhanced levels of glucosinolates (HG broccoli). This broccoli has been used in previous intervention studies (e.g. ClinicalTrials.gov NCT00535977). Volunteers will be asked to consume 400g of standard broccoli, HG broccoli or peas ...
Myrosinase (EC 3.2.1.147, thioglucoside glucohydrolase, sinigrinase, and sinigrase) is a family of enzymes involved in plant defense against herbivores. The three-dimensional structure has been elucidated and is available in the PDB (see links in the infobox). A member of the glycoside hydrolase family, myrosinase possesses several similarities with the more ubiquitous O-glycosidases. However, myrosinase is the only known enzyme found in nature that can cleave a thio-linked glucose. Its known biological function is to catalyze the hydrolysis of a class of compounds called glucosinolates. Myrosinase is regarded as a defense-related enzyme and is capable of hydrolyzing glucosinolates into various compounds, some of which are toxic. Myrosinase catalyzes the chemical reaction a thioglucoside + H2O ⇌ {\displaystyle \rightleftharpoons } a sugar + a thiol Thus, the two substrates of this enzyme are thioglucoside and H2O, whereas its two products are sugar and thiol. In the presence of water, ...
What else does kale have in it? Yep. You guessed it - glucosinolates. Now, I am sure everyone knows the deal with glucosinolates….What? You mean you dont??? Well, let me hit you with some knowledge!. Glucosinolates are compounds found in high concentrations in leafy green vegetables (especially kale). These molecules are especially cool because they activate the bodys own antioxidant system. This cascade of antioxidant activity actually cycles over and over within the body and continues to protect your system as many as 3 to 4 days after the glucosinolate-containing food has been consumed. Talk about protection! By this process, glucosinolates help the liver eliminate toxic molecules.. These toxins come from many sources: cigarette smoke, pollution, drugs, even free radicals generated by our own bodies in response to illness. So the big picture here is even if you eat super clean, it is good to have some kale in your diet to protect against the bad stuff that may be floating around in your ...
Glucosinolates and their products have a negative effect on many insects, resulting from a combination of deterrence and toxicity. In an attempt to apply this principle in an agronomic context, some glucosinolate-derived products can serve as antifeedants, i.e., natural pesticides.[15]. In contrast, the diamondback moth, a pest of cruciferous plants, may recognize the presence of glucosinolates, allowing it to identify the proper host plant.[16] Indeed, a characteristic, specialised insect fauna is found on glucosinolate-containing plants, including butterflies, such as large white, small white, and orange tip, but also certain aphids, moths, such as the southern armyworm, sawflies, and flea beetles.[citation needed] For instance, the large white butterfly deposits its eggs on these glucosinolate-containing plants, and the larvae survive even with high levels of glucosinolates and eat plant material containing glucosinolates.[citation needed] The whites and orange tips all possess the so-called ...
Authors: (Olga Nydia Campas-Baypoli, Ernesto Uriel Cant -Soto, Jos Antonio Rivera-Jacobo, Departamento de Biotecnolog a y Ciencias Alimentarias. Instituto Tecnol gico de Sonora. Cd. Obreg n, Sonora, M xico ...
Cabbage has long been known as a fantastic food for the reduction of cancer risk, and for the healing of the intestinal tract. It turns out that there are numerous factors that play into those abilities. These include the beneficial fibers in cabbage, the content of glutamine (an amino acid-like substance used by intestinal cells for healing), and a high content of miraculous compounds called glucosinolates. Glucosinolates are sulfur containing molecules that have glucose attached to them. When you break open the cell walls of cabbage, an enzyme is released called myrosinase that removes the glucose from the sulfur compounds commonly called isothiocyanates. One of these isothiocyanates, sulforaphane, has an amazing capacity to turn on a part of our genes called the Antioxidant Response Element. When it does this, we start producing more antioxidant proteins, and detoxification proteins (enzymes actually) that provide us 72 hours of protection from environmentally and internally produced toxins. ...
The carbon/nutrient balance hypothesis has recently been interpreted to predict that plants grown under elevated CO2 environments will allocate excess carbon to defense, resulting in an increase in ca
S-adenosyl-L-methionine-dependent methyltransferase. Involved in glucosinolate metabolism and defense against phytopathogens (By similarity).
Jørgensen ME, Olsen CE, Geiger D, Mirza O, Halkier BA, Nour-Eldin HH (2015) A functional EXXEK motif is essential for proton coupling and active glucosinolate transport by NPF2.11 . Plant Cell Physiol 56: 2340-2350.. Soltis NE, Kliebenstein DJ (2015) Natural variation of plant metabolism: genetic mechanisms, interpretive caveats, and evolutionary and mechanistic insights. Plant Physiol 169: 1456-1468.. Cacho NI, Kliebenstein DJ, Strauss SY (2015) Macroevolutionary patterns of glucosinolate defense and tests of defense-escalation and resource availability hypotheses. New Phytol 208: 915-927.. Madsen SR, Kunert G, Reichelt M, Gershenzon J, Halkier BA (2015) Feeding on leaves of the glucosinolate transporter mutant gtr1gtr2 reduces fitness of Myzus persicae. J Chem Ecol 41: 975-984.. Zhang Y, Huai D, Yang Q, Cheng Y, Ma M, Kliebenstein DJ, Zhou Y (2015) Overexpression of three glucosinolate biosynthesis genes in Brassica napus identifies enhanced resistance to Sclerotinia sclerotiorum and Botrytis ...
Study 21 Glucosinolates flashcards from Ben Holtom's University Of Guelph class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Healthy Kale Kale is a nutritionally packed leafy vegetable that contains incredible healing and rejuvenating properties. Kale is rich in omega-3 fatty acids, chlorophyll, amino acids, vitamins A, C, E, K, B-complex and minerals such as iron, magnesium, copper, and potassium. Kale is an anti-cancer powerhouse and contains phytochemicals such as glucosinolates that help protect the body from breast, colon, prostate, ovarian, and bladder cancer. These glucosinolates are also known to detox the body on genetic level and have the ability to literally transform your body and health. Kale also contains an exceptionally high amount of antioxidants such as carotenoids and flavonoids which are essential for protecting the body from degenerative diseases such as heart disease, diabetes, prostatitis, osteoporosis, and neurological disorders. Kale contains an organic sulfur which has potent antibiotic, antiviral, and anti-inflammatory properties that work to boost to the immune system and provide ...
In addition, the chemical process of fermenting food appears to enhance the presence of some nutrients. Researchers in Poland have been investigating the healthy effects of fermented cabbage (sauerkraut). When cabbage is fermented the amount of glucosinolate increases. Glucosinolate has anti-cancer properties. Other research has found nutrients other than glucosinolates are enhanced during fermentation, including vitamin C and many B vitamins. Fruits and vegetables contain enzymes which the human body does not produce. Eating fermented plant foods may offer even more beneficial enzymes to enhance digestion. In addition, researchers have been noting how the presence of fibrinolytic enzymes in many popular Japanese fermented foods, including fermented shrimp paste and natto, help dissolve fibrin clots. Fibrin clots are a risk factor in heart disease, the leading cause of death in North America. Beware of Less Healthy Imposters ...
Broccoli has a strong, positive impact on our bodys detoxification system, and researchers have recently identified one of the key reasons for this detox benefit. Glucoraphanin, gluconasturtiian, and glucobrassicin are 3 glucosinolate phytonutrients found in a special combination in broccoli. This dynamic trio is able to support all steps in bodys detox process, including activation, neutralization, and elimination of unwanted contaminants. Isothiocyanates (ITCs) are the detox-regulating molecules made from broccolis glucosinolates, and they help control the detox process at a genetic level ...
ABSTRACT: Flavin monooxygenase (FMO) is one of the most important enzymes involved in glucosinolate biosynthesis. In this study, the full length of FMO gene (RsFMOgs-ox1) encoding a putative FMO protein composed of 450 amino acids was successfully cloned using the RACE-PCR method. The amino acid sequence of RsFMOgs-ox1 has high similarities of 92% and 83% with BrFMOgs-ox1 and AtFMOgs-ox1,2,3, respectively, and the gene structure of FMOgs-ox1 is similar to its plant homologues. Quantitative (qPCR) analysis revealed that RsFMOgs-ox1 was highly expressed during early seedling development. In mature radish, the highest expression was observed in the leaves, while the lowest transcript was evident in the root. The expression of RsFMOgs-ox1 was also regulated by wounding, notably 1 day after treatment. Subcellular localization in Arabidopsis showed that RsFMOgs-ox1 was localized in the cytoplasm and nuclei. This study allows us to understand something about RsFMOgs-ox1 function in glucosinolate ...
Broccoli, cabbage, and cauliflower have a chemical component called indole-3-carbinol that can combat breast cancer by converting a cancer-promoting estrogen into a more protective variety. Broccoli, especially sprouts, also have the phytochemical sulforaphane, a product of glucoraphanin - believed to aid in preventing some types of cancer, like colon and rectal cancer. Sulforaphane induces the production of certain enzymes that can deactivate free radicals and carcinogens. The enzymes have been shown to inhibit the growth of tumors in laboratory animals. However, be aware that the Agriculture Department studied 71 types of broccoli plants and found a 30-fold difference in the amounts of glucoraphanin. It appears that the more bitter the broccoli is, the more glucoraphanin it has. Broccoli sprouts have been developed under the trade name BroccoSprouts that have a consistent level of sulforaphane - as much as 20 times higher than the levels found in mature heads of broccoli. Try Curry in a Hurry, ...
Citation: N/A Interpretive Summary: Technical Abstract: The crucifer family, Brassicaceae, is an economically important family for its many food crops. Crucifers are characterized by the presence of a group of secondary compounds called glucosinolates, which with their degradation products are primarily responsible for the characteristic aromas and flavors of crucifers. Glucosinolate degradation products include substituted isothiocyanates, nitriles, thiocyanates, epithionitriles and oxazolidinethiones, which vary depending on the plant species studied, side-chain substitution, cell pH and cell iron concentration. Many of these degradation products have biological activity ranging from insect attractants to suspected human health benefits, but are not commercially available. We have developed methods for isolation and purification of several of these degradation products, including the isothiocyanates erucin, iberin, cheirolin, hesperin, and lesquerellin (as well as most of the corresponding ...
Plant genomes encode numerous small molecule glycosyltransferases which modulate the solubility, activity, immunogenicity and/or reactivity of hormones, xenobiotics and natural products. The products of these enzymes can accumulate to very high concentrations, yet somehow avoid inhibiting their own biosynthesis. Glucosyltransferase UGT74B1 (UDP-glycosyltransferase 74B1) catalyses the penultimate step in the core biosynthetic pathway of glucosinolates, a group of natural products with important functions in plant defence against pests and pathogens. We found that mutation of the highly conserved Ser284 to leucine [wei9-1 (weak ethylene insensitive)] caused only very mild morphological and metabolic phenotypes, in dramatic contrast with knockout mutants, indicating that steady state glucosinolate levels are actively regulated even in unchallenged plants. Analysis of the effects of the mutation via a structural modelling approach indicated that the affected serine interacts directly with ...
Plant genomes encode numerous small molecule glycosyltransferases which modulate the solubility, activity, immunogenicity and/or reactivity of hormones, xenobiotics and natural products. The products of these enzymes can accumulate to very high concentrations, yet somehow avoid inhibiting their own biosynthesis. Glucosyltransferase UGT74B1 (UDP-glycosyltransferase 74B1) catalyses the penultimate step in the core biosynthetic pathway of glucosinolates, a group of natural products with important functions in plant defence against pests and pathogens. We found that mutation of the highly conserved Ser284 to leucine [wei9-1 (weak ethylene insensitive)] caused only very mild morphological and metabolic phenotypes, in dramatic contrast with knockout mutants, indicating that steady state glucosinolate levels are actively regulated even in unchallenged plants. Analysis of the effects of the mutation via a structural modelling approach indicated that the affected serine interacts directly with ...
NCT00252018 The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease. [C. Torp-Pedersen, Department of Cardiology, Bispebjerg Hospital, Denmark] The purpose of this study is to investigate whether a daily intake of dried broccoli sprouts will improve the endothelial function of the participants as measured by Flow mediated dilation (FMD). The dried sprouts are chosen because broccoli sprouts are known as containing large amounts of the glucosinolate glucoraphanin which in vitro and in animal models has been shown to have a positive effect on the endothelium as measured by NO release.. Status: Completed. NCT00340743 Diet and Genetic Damage. [J. Taylor, University of North Carolina, Chapel Hill, NC] This study will examine the risks and protective effects of dietary factors on temporary genetic damage to cells lining the gastrointestinal tract and to blood cells. Some foods, including very well done meat, may increase genetic damage in cells, while ...
Broccoli, cabbage, and cauliflower have a chemical component called indole-3-carbinol that can combat breast cancer by converting a cancer-promoting estrogen into a more protective variety. Broccoli, especially sprouts, also have the phytochemical sulforaphane, a product of glucoraphanin - believed to aid in preventing some types of cancer, like colon and rectal cancer. Sulforaphane induces the production of certain enzymes that can deactivate free radicals and carcinogens. It appears that the bitterer the broccoli is, the more glucoraphanin it has. Broccoli sprouts have been developed under the trade name BroccoSprouts that have a consistent level of sulforaphane - as much as 20 times higher than the levels found in mature heads of broccoli. Studies show that consumption of green and yellow leafy vegetables has been associated with lower levels of stomach cancer. ...
Joel Fuhrman, M.D., a physician and New York Times best-selling author who is a renowned expert in nutrition, writes on his website that "Eating a diet rich in cruciferous vegetables is your best defense for fighting and preventing cancer." Why? Fuhrmans studies have demonstrated that cruciferous vegetables are twice as effective as other vegetables, beans, and fruits at reducing cancer rates.. According to the National Cancer Institute, the substances that give cruciferous veggies their sulfur scent and sometimes bitter taste are plant compounds known as glucosinolates, which are a current focus of anticancer research. Glucosinolates have been effective at treating cancer in animal and cellular studies, and current research is looking at their effectiveness in treating cancer in humans. Cruciferous veggies are also high in other key nutrients:. •vitamins C, E, and ...
Glucosinolates (GSLs) are a class of secondary metabolites with allelochemical properties found in members of the Brassicales. GSLs are relatively nontoxic, but after hydrolysis of the sugar moiety by myrosinase (thioglucosidase), the compounds are degraded. The break-down products are highly bioactive, affect germination, growth of neighboring plants and can have antimicrobial effects. Therefore, the GSL/myrosinase complex is a natural plant defense system against diverse pathogens, which has already been used in integrated pest and weed management. Presently, potential negative long-term effects of the GSL hydrolysis products on beneficial soil microorganisms are not known. Bioassays performed in this study are based on analyzing growth suppression of selected pathogenic and beneficial soil fungi by GSLs and their hydrolysis products. Lipid, protein, enzyme and RNA analyses were carried out to systematically characterize GSL derived changes of the soil community structure. On this end, soil of ...
Here is a quick look at what some of these specific nutrients do:. 1. Antioxidants. Zeaxanthin and lutein (both carotenoids): Zeaxanthin and lutein are powerful antioxidants that protect against degenerative illnesses such as cancer, cardio-vascular disease and macular degeneration.. 2. Anti-inflammatory. Vitamin K and Omega-3: Vitamin K and Omega-3 play key roles in reducing inflammation in the body by regulating the inflammatory processes.. 3. Anti-Cancer. Glucosinolates: Kale, along with the rest of the members of the Brassica family (such as cabbage and broccoli), contains a number of these anti-cancer chemicals. These groups of glucosinolates and their derived isothiocyantes block the growth of certain types of cancer cells, boost DNA repair and help cells to detox!. With accolades such as these, why wouldn t kale have its own fan club?. So jump on the kale bandwagon and start enjoying it in your soups, salads, stir fries, smoothies and more today.. Watch out for my next post on six simple ...
Authors: (Sabine Montaut, and Patrick Rollin, Laurentian University, Department of Chemistry & Biochemistry, Biomolecular Sciences Programme, Sudbury, ON, Canada, and others ...
Anti-Cancer Properties - Broccoli probably ranks number one on the list of all round anti-cancer vegetables, with broccoli being the subject to the highest amount of scientific and medical research. Broccoli is considered a major deterrent to lung, stomach, mouth, ovarian, breast, cervix, colon and prostate cancer. The reason broccoli is an, A grade anti cancer food is because it is rich in substances such as indoles, glucosinolates, beta carotene and vitamin C. It also contains high amounts of sulphorane, a substance that has been extensively looked into in laboratories. It is a phytonutrient that catalyses the formation of and function of phase II enzymes within the body. These enzymes have been known to remove or destroy cancer-causing substances from cells under lab conditions. It is speculated that these enzymes will bring about similar results within the human body ...
Dr Oz shows you how to de-stress and how protect your skin, the eyes and the liver with 3 key nutrients that include glucosinolates, zinc and lutein.
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Induced plant defense against pests and diseases encompasses a wide variety of mechanisms, ranging from deposition of callose-rich papillae to accumulation of biocidal defense metabolites. Defensive metabolites can be synthesized de novo in response to microbe or insect attack, such as phytoalexins, but can also be produced constitutively and stored as an inactive form in the plant cell. These so-called phytoanticipins can be activated by β-glucosidase activity during herbivory, which allows for a rapid release of biocidal aglycone metabolites (VanEtten et al., 1994; Morant et al., 2008). Well-characterized examples of phytoanticipins are glucosinolates (GSs), which can be hydrolyzed by endogenous β-thioglucoside glucohydrolases, called myrosinases. Although GSs have traditionally been associated with defense against herbivores, recent insights have revealed that they can also play a role in resistance against microbes. For instance, Bednarek et al. (2009) demonstrated in Arabidopsis ...
There are many benefits of I3C, which is formed from the breakdown of glucobrassicin, naturally found in cruciferous vegetables.. Read More ...
Cyvex Nutrition has launched BroccoSinolate™, a natural antioxidant (glucosinolates), which joins a family of broccoli-based nutraceuticals marketed by the company. BroccoSinolate is extracted from mature broccoli plants stabilized and standard
Im looking for ways to take charge of my diet and start exercising. I am almost 56 years old. I was also diagnosed with hyperglycemia and told to reduce the numbers. What are you eating on a Low Carb diet, my blood pressure is rising and Im not eating salt and Im trying to stay away from sodas and sugar. * Tip This cruciferous vegetable is also a well-known source of anti-cancer phytonutrients called glucosinolates. You can substitute frozen broccoli in many entrees and side dishes. Serve a few with these 3 broccoli recipes ready in 30 minutes or less. A medium sweet potato with skin provides 4% calcium, 8% magnesium 7% without skin, and 15% % of the potassium 10% without the skin you need every day.. * I think I can possibly get out of the BP med. I am still on the verge of being diabetic, but it is a new diagnosis and I can do it too. In 3 weeks, I lost 5 pounds. by eliminating refined sugars in almost everything and eating healthier.. * Receive our free monthly e-magazine directly in your ...
Did you know?Cauliflower is low in fat, high in dietary fiber, folate, water and vitamin C, possessing a very high nutritional density. As a member of the brassica family, cauliflower shares with broccoli and cabbage several phytochemicals which are beneficial to human health, including sulforaphane, an anti-cancer compound released when cauliflower is chopped or chewed. In addition, the compound indole-3-carbinol, which appears to work as an anti-estrogen, appears to slow or prevent the growth of tumors of the breast and prostate.Cauliflower also contains other glucosinolates besides sulfurophane, substances which may improve the livers ability to detoxify carcinogenic substances.A high intake of cauliflower has been found to reduce the risk of aggressive prostate cancer.. ...
Advanced, higher-chain (C ≥ 4) fuels and chemicals are generated from short-chain, 2- or 3-C metabolic intermediates through pathways that require carbon-chain elongation. While we have engineered native carbon-chain elongation pathways, such as the fatty acid biosynthesis pathway, to produce higher-chain molecules like methylketones, this pathway suffers from major energy constraints. Motivated in part by these limitations, we recently engineered a functional reversal of the β-oxidation cycle that can be used as a general platform for the synthesis of short-, medium- and long-chain products with structural and functional diversity. Through a systems-level, quantitative assessment of the metabolic capabilities of the engineered reversal of the β-oxidation cycle, we demonstrated that product synthesis can be coupled to cell growth and achieved at high fluxes, titers and yields. The superior capabilities of the β-oxidation reversal, when compared to other pathways used for carbon-chain ...
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TAS2R38是一种苦味味觉感受器[1][2],该感受器可以尝出苯硫脲[3]和丙硫氧嘧啶[4]或者相关物质的苦味。这一点和大多数苦味感受器有所不同,即该感受器是对某类物质敏感,而大多数感受器则不会表现出强烈的选择性,能对多种物质做出响应[5]。该感受器所能尝出的相应物质大量存在于西兰花、卷心菜以及其它十字花科植物中[5],例如:葡萄糖异硫氰酸盐(英语:Glucosinolates)及其相关产物异硫氰酸酯。目前全球人类中,约有75%该感受器相关基因正常,即,可以尝出苦味。而剩下的25%则无法尝出这类的苦味,或者敏感度较低[6]。 不过目前的研究表明该感受器相关基因的变异与否,并不是决定某个人是否此类苦味物质的超级品尝家(英语:Supertaster)的唯一因素。[7]. ...
Beneforte broccoli contains two to three times more of a naturally occurring compound glucoraphanin. It works by reducing how much LDL-cholesterol our bodies make.