Is the Chronic Kidney Disease Epidemiology Collaboration creatinineâ cystatin C equation useful for glomerular filtration rate estimation in the elderly? Xun Liu,1,2,* Huijuan Ma,1,* Hui Huang,3 Cheng Wang,1 Hua Tang,1 Ming Li,1 Yanni Wang,1 Tanqi Lou1 1Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 2College of Biology Engineering, South China University of Technology, 3Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Peoples Republic of China*These authors contributed equally to the paperBackground: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinineâ cystatin C equation in a cohort of elderly Chinese participants.Materials and methods: Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid (99mTc-DTPA) renal dynamic imaging method, and was
TY - JOUR. T1 - Relation of low glomerular filtration rate to metabolic disorders in individuals without diabetes and with normoalbuminuria. AU - Lorenzo, Carlos. AU - Nath, Subrata D.. AU - Hanley, Anthony J.G.. AU - Abboud, Hanna E.. AU - Haffner, Steven M.. PY - 2008/5/1. Y1 - 2008/5/1. N2 - Background and objectives: Microalbuminuria increases cardiovascular risk and is considered a metabolic disorder. Low glomerular filtration rate is also associated with increased cardiovascular risk, but the relation of low glomerular filtration rate to metabolic disorders is not well understood. Design, setting, participants, & measurements: Designed as a cross-sectional, epidemiologic study, the Insulin Resistance Atherosclerosis Study was conducted in four centers: San Antonio (Texas), San Luis Valley (Colorado), and Oakland and Los Angeles (California). The Modification of Diet in Renal Disease equation was used to classify individuals without diabetes and with normoalbuminuria (n = 856; age 40 to 69 ...
TY - JOUR. T1 - Data on the relation between renal biomarkers and measured glomerular filtration rate. AU - Pottel, Hans. AU - Dubourg, Laurence. AU - Schaeffner, Elke. AU - Eriksen, Bjørn Odvar. AU - Melsom, Toralf. AU - Lamb, Edmund J.. AU - Rule, Andrew D.. AU - Turner, Stephen T.. AU - Glassock, Richard J.. AU - De Souza, Vandréa. AU - Selistre, Luciano. AU - Goffin, Karolien. AU - Pauwels, Steven. AU - Mariat, Christophe. AU - Flamant, Martin. AU - Bevc, Sebastjan. AU - Delanaye, Pierre. AU - Ebert, Natalie. N1 - Funding Information: The Chronic Renal Insufficiency Cohort Study (CRIC) was conducted by the CRIC Investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) . The data from the CRIC Study reported here were supplied by the NIDDK Central Repositories. This manuscript was not prepared in collaboration with Investigators of the CRIC study and does not necessarily reflect the opinions or views of the CRIC study, the NIDDK Central ...
The duration of warm ischemia time is associated with short and long-term kidney transplant function. A quick rise in graft temperature is reported during the vascular anastomosis. This study was initiated, to gain insight into the effect of graft temperature on short-term transplant function. From 2013 to 2015, data of living donor kidney transplant recipients was prospectively collected. At set intraoperative timepoints, the graft temperature was measured using a non-contact infrared thermometer. Primary endpoint was measured glomerular filtration rate (mGFR) at 3- and 6-months post-transplantation. Univariable and multivariable associations were identified using linear regression analyses. Multivariable analysis included models with donor, recipient and procedure characteristics. We evaluated 152 patients, 83 (55%) were male, mean ±SD age was 50.3 ±13.4 years and 79 (52%) were pre-emptively transplanted. In univariable analysis graft temperature, after 10 minutes of warm ischemia, was ...
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). During the clinical development programme, increases in mean serum creatinine (SCr) of approximately 0.07 mg/dL and 0.08 mg/dL were observed which plateaued early. This study assessed changes in measured glomerular filtration rate (mGFR) with tofacitinib relative to placebo in patients with active RA. This was a randomised, placebo-controlled, Phase 1 study ( NCT01484561 ). Patients were aged ≥18 years with active RA. Patients were randomised 2:1 to oral tofacitinib 10 mg twice daily (BID) in Period 1 then placebo BID in Period 2 (tofacitinib → placebo); or oral placebo BID in both Periods (placebo → placebo). Change in mGFR was evaluated by iohexol serum clearance at four time points (run-in, pre-dose in Period 1, Period 1 end, and Period 2 end). The primary endpoint was the change in mGFR from baseline to Period 1 end. Secondary endpoints
TY - JOUR. T1 - Performance of formulas for estimating glomerular filtration rate in Indigenous Australians with and without Type 2 diabetes: The eGFR Study. AU - Maple-Brown, Louise. AU - Ekinci, Elif. AU - Hughes, Jaquelyne. AU - Chatfield, Mark. AU - Lawton, Paul. AU - Jones, Graham. AU - Ellis, Andrew. AU - Sinha, Ashim. AU - Cass, Alan. AU - Hoy, Wendy. AU - ODea, Kerin. AU - Jerums, George. AU - MacIsaac, Richard. PY - 2014/7/1. Y1 - 2014/7/1. N2 - Aims: It has been proposed that the Chronic Kidney Disease Epidemiology Collaboration formula estimates glomerular filtration rate more accurately than the Modification of Diet in Renal Disease formula. With the very high incidence of diabetes and end-stage kidney disease in Indigenous Australians, accurate estimation of glomerular filtration rate is vital in early detection of kidney disease. We aimed to assess the performance of the Chronic Kidney Disease Epidemiology Collaboration, Modification of Diet in Renal Disease and Cockcroft-Gault ...
Reduced glomerular filtration rate and increased asymmetric dimethylarginine (ADMA) are prevalent in elderly people. However, most of the studies that have examined the association between the two conditions were performed in patients with renal dysfunction, but not in the general elderly population. Thus, we investigated an association between estimated glomerular filtration rate (eGFR) and ADMA concentration among community-dwelling older Koreans. A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based cohort study of health determinants in elderly Koreans. We calculated eGFR using chronic kidney disease- Epidemiology Collaboration Group (CKD-EPI) equation. ADMA concentration was measured by an enzyme-linked immunosorbent assay. The association between eGFR and ADMA concentrations was analyzed by multiple linear regression models. The mean ADMA was significantly higher in people with
The aim of this study was to determine whether the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)- or Cockcroft-Gault (CG)-based estimated glomerular filtration rates (eGFRs) performs better in the cohort setting for predicting moderate/advanced chronic kidney disease (CKD) or end-stage renal disease (ESRD ...
TY - JOUR. T1 - The power of renal function estimation equations for predicting long-term kidney graft survival a retrospective comparison of the chronic kidney disease epidemiology collaboration and the modification of diet in renal disease study equations. AU - Choi, Hoon Young. AU - Joo, Dong Jin. AU - Song, Mi Kyung. AU - Kim, Myoung Soo. AU - Park, Hyeong Cheon. AU - Kim, Yu Seun. AU - Kim, Beom Seok. N1 - Publisher Copyright: © 2016 Wolters Kluwer Health, Inc. All rights reserved.. PY - 2016. Y1 - 2016. N2 - Evaluation of renal function using an accurate estimation equation is important for predicting long-term graft survival. We designed this retrospective cohort study to evaluate the predictive power of renal function estimation by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) study equations for graft survival. We reviewed data of 3290 adult kidney transplant recipients who underwent transplantation at a single ...
Definition of glomerular filtration rate in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is glomerular filtration rate? Meaning of glomerular filtration rate as a legal term. What does glomerular filtration rate mean in law?
The Kidney Disease Outcome Quality Initiative of the National Kidney Foundation published clinical practice guidelines on chronic kidney disease in February 2002. Of the 15 guidelines, the first six are of greatest relevance to family physicians. Part II of this two-part review covers guidelines 4, 5, and 6. Glomerular filtration rate is the best overall indicator of kidney function. It is superior to the serum creatinine level, which varies with age, sex, and race and often does not reflect kidney function accurately. The glomerular filtration rate can be estimated using prediction equations that take into account the serum creatinine level and some or all of specific variables (age, sex, race, body size). In many patients, estimates of the glomerular filtration rate can replace 24-hour urine collections for creatinine clearance measurements. Urine dipsticks generally are acceptable for detecting proteinuria. To quantify proteinuria, the ratio of protein or albumin to creatinine in an untimed (spot)
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AimsWe aimed to investigate the impact of admission estimated glomerular filtration rates (eGFR) on the development of poor myocardial perfusion after primary percutaneous coronary intervention (pPCI) in patients presenting with acute ST-segment-elevation myocardial infarction (STEMI).Materials and
The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p=0.7709, women:p=0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese ...
Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR). To develop an equation to predict GFR from serum creatinine concentration and other factors. Cross-sectional study of GFR, creatinine clearance, serum creatinine concentration, and demographic and clinical characteristics in patients with chronic renal disease. 1628 patients enrolled in the baseline period of the Modification of Diet in Renal Disease (MDRD) Study, of whom 1070 were randomly selected as the training sample; the remaining 558 patients constituted the validation sample. The prediction equation was developed by stepwise regression applied to the training sample. The equation was then tested and compared with other prediction equations in the validation sample. To simplify prediction of GFR, the equation included only demographic and serum variables. Independent factors associated with a lower GFR included a higher ...
Title: Prediction of Glomerular Filtration Rate From Body Cell Mass and Plasma Creatinine. VOLUME: 1 ISSUE: 3. Author(s):Carlo Donadio, Cristina Consani, Michela Ardini, Francesca Caprio, Giulia Grassi and Annalisa Lucchesi. Affiliation:Division of Nephrology, Department of Internal Medicine, University of Pisa, I-56100 Pisa, Italy.. Keywords:glomerular filtration rate, estimate of renal function, plasma creatinine, body composition, electrical body impedance, body cell mass, renal excretion of drugs, renal failure. Abstract: The gold standards for the measurement of glomerular filtration rate (GFR) are inulin clearance and radioisotopic methods. However, creatinine clearance is the most used test to evaluate GFR in clinical practice. Its adequacy is questionable, since its repeatability is quite poor, mainly due to errors in the collection of urine. The aim of this study was to evaluate a new method to predict GFR from the body cell mass (BCM) and plasma creatinine (Pcr), avoiding urine ...
TY - JOUR. T1 - Mild decrease in estimated glomerular filtration rate and proteinuria are associated with all-cause and cardiovascular mortality in the general population. AU - Oh, Se Won. AU - Baek, Seon Ha. AU - Kim, Yong Chul. AU - Goo, Ho Suk. AU - Heo, Nam Ju. AU - Na, Ki Young. AU - Chae, Dong Wan. AU - Kim, Suhnggwon. AU - Chin, Ho Jun. PY - 2012/6/1. Y1 - 2012/6/1. N2 - Background. A recent collaborative meta-analysis by Kidney Disease: Improving Global Outcomes reported that an estimated glomerular filtration rate (eGFR) ,60 mL/min/1.73m 2 and an albumin-to-creatinine ratio of ≥10 mg/g were independent predictors for mortality in the general population. However, selection bias, heterogeneity of the cohorts and measurement issues could be limitations.Methods.We analyzed the relationship of eGFR and proteinuria with mortality in the Korean general population, represented by 112115 participants, aged ≥20 years, who had a voluntary health check-up with homogenous calibration of ...
TY - JOUR. T1 - Relationship between arterial stiffness and renal function determined by CKD-EPI and MDRD equations in a Chinese cohort undergoing health assessment. AU - Tang, Biwen. AU - Zhao, Jiehui. AU - Deng, Xueqin. AU - Tan, Isabella. AU - Butlin, Mark. AU - Avolio, Alberto. AU - Zuo, Junli. PY - 2021/4. Y1 - 2021/4. N2 - Objective: The relationship between the renal function and large arteries remains to be determined. Our study investigated the relationship between carotid-femoral pulse wave velocity (c-fPWV) as a measure of arterial stiffness and renal function in healthy participants. Design and method: Our cross-sectional study was conducted in healthy individuals in China. We enrolled participants from January 2017 to June 2019. c-fPWV and blood pressure were measured and blood samples taken in all participants. Estimated glomerular filtration rate (eGFR) was evaluated by four different formulae using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of ...
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We performed a validation study of 17 preselected plasma protein markers with reported high evidence for the prediction of eGFR decline in patients with type 2 diabetes and incident or early-stage CKD. We showed in an univariable analysis that 9 of the markers had significantly different concentration levels between patients with stable eGFR and fast progression of eGFR decline and that 14 biomarkers significantly contributed to the prediction of eGFR levels. However, most of the predictive ability was attributable to the association with baseline GFR. In the multivariable analysis of eGFR decline over time, only five markers (KIM1, FGF23, NTproBNP, HGF, and MMP1) remained significant but exhibited only a modest predictive power on top of clinical covariates. Furthermore, if the longitudinal analysis was adjusted for baseline eGFR, none of the biomarkers were able to contribute a relevant portion of explained variability, suggesting that baseline eGFR is the key variable in prediction of renal ...
Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients. Impairment in kidney where to get viagra malaysia tubular function in patients receiving tenofovir is associated with higher tenofovir plasma concentrations. Persistent decline in estimated but not measured glomerular filtration rate on tenofovir may reflect prozac and singulair tubular rather than glomerular toxicity. Is phosphatemia the best tool to monitor renal tenofovir toxicity? Effect of prozac and singulair tenofovir on renal glomerular and tubular function. Randomized controlled trial of once-daily tenofovir, lamivudine, and lopinavir/ritonavir versus remaining on the prozac and singulair same regimen in virologically suppressed HIV-infected patients jiyong topamax on their first PI-containing HAART regimen. The safety of tenofovir disoproxil fumarate for prozac and singulair prozac and singulair the treatment of HIV infection in adults: the first 4 years. Renal transport ...
Chronic kidney disease (CKD) is defined as the presence of kidney damage or an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 mt2, persisting for 3 months or more, irrespective of the cause.[1] It is a state of progressive loss of kidney function ultimately resulting in the need for renal replacement therapy (dialysis or transplantation). Kidney damage refers to pathologic abnormalities either suggested by imaging studies or renal biopsy, abnormalities in urinary sediment, or increased urinary albumin excretion rates. The 2012 KDIGO CKD classification recommends details about the cause of the CKD and classifies into 6 categories based on glomerular filtration rate (G1 to G5 with G3 split into 3a and 3b). It also includes the staging based on three levels of albuminuria (A1, A2, and A3), with each stage of CKD being sub-categorized according to the urinary albumin-creatinine ratio in (mg/gm) or (mg/mmol) in an early morning
Introduction: Kidney function is an established risk factor for cardiovascular disease (CVD) events [1]. In a high risk CVD population it had been suggested that cystatin C based equations to estimate glomerular filtration rate (eGFR) show better prognostic value than creatinine (Cr) based ones [2]. However, in population-based settings the situation is less clear. In addition it is controversial whether albuminuria carries additional information. The aim of this study was to estimate the association of Cr- and cystatin C-based eGFR and albuminuria with CVD in a population of older adults.. Material & methods: The study included participants, aged 50-75 years, of a statewide cohort study (ESTHER) conducted in the state of Saarland. Stages of chronic kidney disease (CKD) were defined by the Cr based simplified Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease Epidemiology (CKD-EPI), and by the cystatin C based Arnal-Dade estimating equations. Active follow-up was conducted ...
We studied here the independent associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD). We performed a collaborative meta-analysis of 13 studies totaling 21,688 patients selected for CKD of diverse etiology. After adjustment for potential confounders and albuminuria, we found that a 15 ml/min per 1.73 m2 lower eGFR below a threshold of 45 ml/min per 1.73 m2 was significantly associated with mortality and ESRD (pooled hazard ratios (HRs) of 1.47 and 6.24, respectively). There was significant heterogeneity between studies for both HR estimates. After adjustment for risk factors and eGFR, an eightfold higher albumin- or protein-to-creatinine ratio was significantly associated with mortality (pooled HR 1.40) without evidence of significant heterogeneity and with ESRD (pooled HR 3.04), with significant heterogeneity between HR estimates. Lower eGFR and more severe albuminuria ...
Photo: Pixabay physiciansweekly.com The risk for kidney outcomes is increased for COVID-19 survivors in the post-acute phase of the disease, according to a study published in the September issue of the Journal of the American Society of Nephrology. Benjamin Bowe, M.P.H., from the VA Saint Louis Health Care System, and colleagues examined kidney outcomes in a cohort of 1,726,683 U.S. veterans identified from March 1, 2020, to March 15, 2021, including 89,216 30-day COVID-19 survivors and 1,637,467 noninfected controls. The risks for acute kidney injury (AKI), estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease (ESKD), and major adverse kidney events (MAKE) following acute infection were examined. The researchers found that 30-day survivors of COVID-19 had an increased risk for AKI, eGFR decline ≥30 percent, eGFR decline ≥40 percent, eGFR decline ≥50 percent, ESKD, and MAKE (adjusted hazard ratios, 1.94, 1.25, 1.44, 1.62, 2.96, and 1.66, respectively) beyond the
Chronic Kidney Disease (CKD), the worldwide Public Health problem, is also one of the rising non-communicable diseases in low and middle-income countries. Its early detection and treatment using readily available, inexpensive therapies can slow or prevent progression to end-stage renal disease. Hence, this study was aimed at assessing impaired estimated glomerular filtration rate (eGFR), high grade albuminuria, and associated factors among adult patients admitted to Jimma University Medical Center in South west Ethiopia. Hospital based cross sectional study was conducted from November 1, 2016 to April 30, 2017. Consecutive sampling method was used to select study participants. Logistic regression analysis was conducted to generate factors associated with impaired estimated GFR and albuminuria. A P-value of | 0.05 was considered statistically significant. The study involved 422 patients admitted to Jimma University Medical Center who had at least one test result for urinalysis and serum creatinine level
Serum creatinine is measured to assess for the presence of kidney disease, which can be either the cause or the result of hypertension. Serum creatinine alone may overestimate glomerular filtration rate and recent guidelines advocate the use of predictive equations such as the Modification of Diet in Renal Disease (MDRD) formula to estimate glomerular filtration rate (eGFR).[27] eGFR can also provide a baseline measurement of kidney function that can be used to monitor for side effects of certain anti-hypertensive drugs on kidney function. Additionally, testing of urine samples for protein is used as a secondary indicator of kidney disease. Electrocardiogram (EKG/ECG) testing is done to check for evidence that the heart is under strain from high blood pressure. It may also show whether there is thickening of the heart muscle (left ventricular hypertrophy) or whether the heart has experienced a prior minor disturbance such as a silent heart attack. A chest X-ray or an echocardiogram may also be ...
TY - JOUR. T1 - Limitations of estimating glomerular filtration rate from serum creatinine in the general population. AU - Rule, Andrew D. AU - Rodeheffer, Richard J.. AU - Larson, Timothy S.. AU - Burnett, John C Jr.. AU - Cosio, Fernando G. AU - Turner, Stephen T. AU - Jacobsen, Steven J.. PY - 2006. Y1 - 2006. N2 - OBJECTIVE: To compare estimated glomerular filtration rate (GFR) In the general population on the basis of equations derived from different subsets of the general population. PARTICIPANTS AND METHODS: Admits (ages ≥45 years) were randomly selected from 1997 to 2000 from the Olmsted County, Minnesota, population and had their serum creatinine levels measured. The GFR was estimated using previously reported equations derived tram a sample of patients with chronic kidney disease (CKD), a sample of healthy persons, and the combined samples. Serum creatinine was measured with the same assay used to derive these equations. RESULTS: Of 4203 subjects, 2042 (47% participation rate) were ...
6], GFR can be accurately measured using radioactive substances, in particular chromium-51 and technetium-99m. [citation needed], A decreased renal function can be caused by many types of kidney disease. The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomeular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowmans capsule. A glomerular filtration rate can be estimated with great accuracy, based on the result of another blood test called creatinine. For comparison purposes, the results for three prevalent formulas used for estimating GFR are provided. Glomerular filtration rate (GFR) is an important clinical indicator of kidney function. The activation of vitamin D1, the formation of glucose in the fasting state, and the creation of peptide hormones (including insulin) all ...
Glomerular filtration rate (GFR) is the important index for measuring kidney function. Generally speaking, if the gfr declines, it means your kidneys will be damaged and renal function decline. Can kidney glomerular filtration rate be incre
Chronic kidney disease (CKD) is a worldwide problem. This study was designed to survey the prevalence and risk factors for CKD in Korea. The 2,356 subjects were selected in proportion to age, gender, and city. Subjects 35 yr of age or older were selected from 7 cities. Estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) Study equation, with albuminuria defined as a urine albumin to creatinine ratio of 30 mg/g or more. The overall prevalence of CKD was 13.7%. The prevalences of CKD according to stage were 2.0% stage 1, 6.7% stage 2, 4.8% stage 3, 0.2% stage 4, and 0.0% stage 5. The prevalences of microalbuminuria and macroalbuminuria were 8.6% and 1.6%, respectively. The prevalence of eGFR less than 60 mL/min/1.73 m(2) was 5.0%. Age, body mass index (BMI), hypertension, diabetes mellitus, systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose were independent factors related to the presence of CKD. In ...
Effects of a K+ channel blocker on glomerular filtration rate and electrolyte excretion in conscious rats were observed. Effects of K+ channel modulation on glomerular filtration rate and electrolyte excretion were studied using the adenosine-triphosphate- (ATP)-sensitive K+ channel blocker 4-morpholinecarboximidine-N-1-adamantyl-N-cyclohexylhydr ochloride (U-37883A) in conscious rats previously equipped with catheters for clearance studies. In saline-loaded rats, i.v. doses of U-37883A of 1.7, 5.0 and 15 mg/kg increased absolute and fractional Na+ excretion dose-dependently without changing K+ excretion. The glomerular filtration rate remained constant during diuresis. In water-loaded (hypotonic dextrose) rats, free-water clearance studies revealed that the ATP-sensitive K+ channel blocker significantly decreased an index of solute reabsorption (free-water clearance adjusted for chloride clearance) in the diluting segment during peak natriuretic activity. In addition, U-37883A significantly ...
Patients with chronic kidney disease and severely decreased glomerular filtration rate (GFR) are at high risk for kidney failure, cardiovascular disease (CVD) and death. Accurate estimates of risk and timing of these clinical outcomes could guide patient counseling and therapy. Therefore, we developed models using data of 264,296 individuals in 30 countries participating in the international Chronic Kidney Disease Prognosis Consortium with estimated GFR (eGFR)s under 30 ml/min/1.73m2. Median participant eGFR and urine albumin-to-creatinine ratio were 24 ml/min/1.73m2 and 168 mg/g, respectively. Using competing-risk regression, random-effect meta-analysis, and Markov processes with Monte Carlo simulations, we developed two- and four-year models of the probability and timing of kidney failure requiring kidney replacement therapy (KRT), a non-fatal CVD event, and death according to age, sex, race, eGFR, albumin-to-creatinine ratio, systolic blood pressure, smoking status, diabetes mellitus, and ...
BACKGROUND: Proteinuria is included in the Kidney Disease: Improving Global Outcomes (KDIGO) risk stratification for chronic kidney disease (CKD) in the general population. However, the importance of proteinuria in patients with renal cancer has not been adequately studied. OBJECTIVE: To evaluate the prognostic impact of preoperative proteinuria on overall survival (OS) and renal function stability (RFS) for patients managed with renal cancer surgery. DESIGN, SETTING, AND PARTICIPANTS: From 1999 to 2008, 977 patients who underwent renal cancer surgery had preoperative data recorded for the glomerular filtration rate (GFR) estimated using the CKD Epidemiology Collaboration equation (G1 ≥90, G2 60-89, G3a 45-59, G3b 30-44, G4 15-29, and G5 ,15ml/min/1 ...
FRIDAY, April 14, 2017 (HealthDay News) -- Kidney disease is a major cause of cardiovascular deaths worldwide, according to a study published online April 13 in the Journal of the American Society of Nephrology.. Based on data from 188 countries at six time points between 1990 and 2013, the researchers estimated that in 2013, reduced glomerular filtration rate was associated with 4 percent of deaths worldwide, or 2.2 million deaths. More than half of these deaths (1.2 million) were cardiovascular-related, while 0.96 million were caused by end-stage renal disease.. The investigators also found that reduced glomerular filtration rate ranked below high systolic blood pressure, high body mass index, and high fasting plasma glucose, but was similar to high total cholesterol, as a risk factor for disability-adjusted life years.. Understanding the true health impact of kidney disease on society necessitates considering cardiovascular as well as end-stage renal disease deaths and disability, study ...
Rayner, Hugh C and Rosansky, Steven Jay (2018) The estimated glomerular filtration rate graph: another tool in the management of patients with advanced chronic kidney disease. Kidney international, 94 (1). p. 222. ISSN 1523-1755. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs Full text not available from this repository ...
Approval is the most significant advancement in the treatment of chronic kidney disease in more than 20 years. In DAPA-CKD Phase III trial, Farxiga demonstrated unprecedented reduction in the risk of the composite of worsening of renal function, end-stage kidney disease and cardiovascular or renal death. AstraZenecas Farxiga (dapagliflozin), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has been approved in the US to reduce the risk of sustained estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease (ESKD), cardiovascular (CV) death and hospitalisation for heart failure (hHF) in adults with chronic kidney disease (CKD) at risk of progression.. The approval by the Food and Drug Administration (FDA) was based on positive results from the DAPA-CKD Phase III trial. The decision follows the Priority Review designation granted by the FDA earlier this year.. CKD, a condition defined by decreased kidney function, is often associated with a heightened risk of heart disease ...
Early kidney disease is asymptomatic and strongly associated with morbidity and mortality, hence an accurate estimation of kidney function is crucial for its diagnosis. In turn, an appropriate diagnosis and treatment of chronic and acute kidney disease depends on early detection. Currently markers like blood concentrations of creatinine and Cystatin-C are used to estimate glomerular filtration rate, and others as proteinuria help to assess renal damage, but all of these have different limitations indicating the need for new biomarkers that can discriminate and detect damage, especially in the most critical situation during the development of kidney disease. Given that kidneys are the most important excretory organ, changes in blood concentration levels of a wide variety of metabolites can be a reflection of reduction of kidney function and renal damage. An ideal biomarker for renal disease has to be able to predict early diagnosis of kidney disease, allowing for identification of the type and ...
Background:Observational studies relying on clinically obtained data have shown that acute kidney injury (AKI) is linked to accelerated chronic kidney disease (CKD) progression. However, prior reports lacked uniform collection of important confounders such as proteinuria and pre-AKI kidney function trajectory, and may be susceptible to ascertainment bias, as patients may be more likely to undergo kidney function testing after AKI. Methods:We studied 444 adults with CKD who participated in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study and were concurrent members of a large integrated healthcare delivery system. We estimated glomerular filtration rate (eGFR) trajectories using serum creatinine measurements from (i) the CRIC research protocol (yearly) and (ii) routine clinical care. We used linear mixed effects models to evaluate the associations of AKI with acute absolute change in eGFR and post-AKI eGFR slope, and explored whether these varied by source of creatinine results. ...
Methods : Data from patients who met the criteria for the Kidney Disease Outcomes Quality Initiative(K/DOQI) CKD stage 2 to 4 between August 1999 and March 2007 were retrospectively analyzed. The estimated glomerular filtration rate(eGFR) was calculated by the Schwartz formula, using serum creatinine levels and height. We calculated the annual eGFR change from the difference between the baseline eGFR and the last eGFR divided by the duration(years) of the follow-up period. We analyzed the association between the annual eGFR change and factors such as age, gender, K/DOQI stage, underlying renal disease, serum calcium, and inorganic phosphorous during the follow-up period ...
Dive into the research topics of Effect of a cooked meat meal on serum creatinine and estimated glomerular filtration rate in diabetes related kidney disease.. Together they form a unique fingerprint. ...
factors affecting glomerular filtration rate:Effective filtration pressure The changes in any of the three factors that affect the effective filtration pressure can affect the effective filtration pressure, thereby altering the glomerular filtration r
Background: The DIAMOND study of de novo liver transplant patients showed that prolonged-release tacrolimus exposure in the acute post-transplant period maintained renal function over 24 weeks of treatment. To assess these findings further, we performed a post-hoc analysis in patients according to baseline kidney function, Model for End-stage Liver Disease [MELD] scores, and donor age. Material/Methods: Patients received prolonged-release tacrolimus (initial-dose, Arm 1: 0.2 mg/kg/day, Arm 2: 0.15-0.175 mg/kg/day, Arm 3: 0.2 mg/kg/day delayed until Day 5), mycophenolate mofetil and 1 steroid bolus. Arms 2 and 3 also received basiliximab. The recommended tacrolimus target trough levels to Day 42 post-transplantation were 5-15 ng/mL in all arms. In this post-hoc analysis, change in renal outcome, based on estimated glomerular filtration rate (eGFR), Modified Diet in Renal Disease-4 (MDRD4), values from baseline to Week 24 -post-transplantation, were assessed according to baseline patient factors: ...
TY - JOUR. T1 - Discontinuation of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Chronic Kidney Disease. AU - Qiao, Yao. AU - Shin, Jung Im. AU - Sang, Yingying. AU - Inker, Lesley A.. AU - Secora, Alex. AU - Luo, Shengyuan. AU - Coresh, Josef. AU - Alexander, G. Caleb. AU - Jackson, John W.. AU - Chang, Alex R.. AU - Grams, Morgan E.. PY - 2019/11/1. Y1 - 2019/11/1. N2 - Objective: To assess the patterns of angiotensin converting enzyme inhibitors and angiotensin receptor blockers (ACE-I/ARB) discontinuation in the setting of chronic kidney disease (CKD) progression in real-world clinical practice. Patients and Methods: We identified incident ACE-I/ARB users with a baseline estimated glomerular filtration rate (eGFR) ≥15 mL/min/1.73 m2 and without end-stage renal disease in the Geisinger Health System between January 1, 2004, and December 31, 2015. We investigated the associations of CKD stage, hospitalizations with and without acute kidney injury (AKI), serum ...
Clinical assessment of kidney function is part of routine medical practice for adults, essential for assessing overall health, interpreting signs and symptoms, dosing drugs that are excreted by the kidneys, preparing for invasive diagnostic or therapeutic procedures, and detecting, evaluating and monitoring acute and chronic kidney diseases. The glomerular filtration rate (GFR) is considered the best overall index of kidney function in health and disease. GFR cannot be measured easily in clinical practice. Instead, GFR is estimated from equations using serum creatinine, age, race, sex and body size (1,2). One such equation, the Modification of Diet in Renal Disease (MDRD) Study equation, has gained widespread acceptance (3,4), and estimated GFR using this equation is reported by most clinical laboratories when measurement of serum creatinine is ordered (5). The MDRD Study equation is also used to assess the burden of chronic kidney disease in epidemiologic studies and public health (6). ...
The clinical assessment of the urinary tract generally focuses separately upon (i) identifying the presence of a disease and (ii) evaluating the effects of a disease process upon function of the tract. Thus, renal structure and function must be evaluated separately as they are often not clearly related. Tests performed to detect the presence of structural change affecting the kidneys include urinalysis, imaging studies, and renal biopsy. The impact of a disease process on renal function, however, is generally assessed by tests that evaluate glomerular filtration rate (e.g., measurement of serum concentrations of creatinine and blood urea nitrogen or specialized tests to estimate glomerular filtration rate and renal blood flow), glomerular permselectivity (e.g., measures of proteinuria), and by consideration of renal solute handling and urinary concentrating ability. Evaluating glomerular function: Glomerular filtration rate (GFR) Massive amounts of glomerular filtrate are formed continuously, ...
An ongoing debate is focused on race-based algorithms in medicine-such as an adjustment for Black race in equations that estimate individuals kidney function. A study appearing in an upcoming issue of JASN examines the impact of dropping this race adjustment on patient care.. Assessing individuals kidney function plays an important role in screening for and treating kidney diseases, and current methods primarily rely on estimating kidney function, whats known as a patients estimated glomerular filtration rate (eGFR), from the serum creatinine level. The most commonly used eGFR equation includes an adjustment for Black versus non-Black race, resulting in higher eGFR values for a Black patient compared with a non-Black patient. Recognizing that race is a social and not a biological construct, however, several healthcare institutions no longer report eGFR with an adjustment for Black race, and ASN and the National Kidney Foundation have recently endorsed the idea that race modifiers should not ...
TY - JOUR. T1 - Renal dysfunction in patients with heart failure with preserved versus reduced ejection fraction impact of the new chronic kidney disease-epidemiology collaboration group formula. AU - McAlister, Finlay A.. AU - Ezekowitz, Justin. AU - Tarantini, Luigi. AU - Squire, Iain. AU - Komajda, Michel. AU - Bayes-Genis, Antoni. AU - Gotsman, Israel. AU - Whalley, Gillian. AU - Earle, Nikki. AU - Poppe, Katrina K.. AU - Doughty, Robert N.. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Background-Prior studies in heart failure (HF) have used the Modification of Diet in Renal Disease (MDRD) equation to calculate estimated glomerular filtration rate (eGFR). The Chronic Kidney Disease-Epidemiology Collaboration Group (CKD-EPI) equation provides a more-accurate eGFR than the MDRD when compared against the radionuclide gold standard. The prevalence and prognostic import of renal dysfunction in HF if the CKD-EPI equation is used rather than the MDRD is uncertain. Methods and Results-We used individual ...
AT THE ANNUAL MEETING OF AADE. SAN DIEGO (FRONTLINE MEDICAL NEWS) - Assessing the risk of kidney disease in diabetes requires estimating the glomerular filtration rate. One of the big campaigns is Know Your Numbers, and we think of ABC, also known as hemoglobin A1c, blood pressure, and cholesterol levels, noted Andrew Bzowyckyj, PharmD, BCPS, CDE. Now we have eGFR, which measures kidney function. Its something quantifiable that patients can follow.. Earlier this year, the Food and Drug Administration encouraged wider use of metformin in certain patients with kidney disease based on estimated glomerular filtration rate (eGFR) levels. But some providers havent fully embraced the importance of eGFR in evaluating the appropriateness of metformin, Dr. Bzowyckyj says. Weve all been so entranced by looking at serum creatinine since 1994, when metformin was introduced in the United States, he says. Theres 20 years of history you have to undo. Dr. Bzowyckyj of the University of ...
This page includes the following topics and synonyms: Creatinine Clearance, Glomerular Filtration Rate, GFR, CrCl, Cockcroft-Gault, Modification of Diet in Renal Disease, MDRD, Chronic Kidney Disease Epidemiology Collaboration, CKD-EPI.