Metabolism by peptidases plays an important role in modulating the levels of biologically active neuropeptides. One of these neuropeptides, substance P (SP), a component of gingival crevicular fluid (GCF), may exponentiate the inflammatory process during orthodontic tooth movement. The aim of this study was to investigate the GCF levels of SP in patients using different bracket systems. Subjects were 10 patients (four males, six females; mean age, 25.1 4.4 years) undergoing orthodontic movement (leveling) in the maxilla. Conventional brackets were placed on the left side, while the teeth on the right received self-ligating brackets. The teeth on the mandibular left side without any orthodontic attachments served as controls. GCF was sampled at 0, 1, 24, and 168 hours after initiation of treatment. Prevention of plaque-induced inflammation allowed assessment of the dynamics of mechanically stimulated SP levels in the GCF, which was determined using commercially enzyme-linked immunoabsorbent assay ...
Periodontitis, is an infectious ailment of multifactorial origin, that brings about destruction of bone and surrounding tissues. There are various oral pathogens that may be responsible for the destruction. The host encounters these microbial invasions and their products by the production and release of inflammatory mediators from the cells within the body. Glutathione-S-transferase (GST) are a group of enzymes that utilize glutathione in conditions resulting in oxidative stress. These enzymes play a key role in the detoxifycation of such substance. It aids in preventing damage to important cellular components caused by release of free reactive oxygen species. Ceruloplasmin is a ferroxidase enzyme. It plays a role as an anti-inflammatory agent, by its ability to scavenge free radicals within the body. The present study was targeted at evaluating the levels of Glutathione-S-Transferase (GST) and Ceruloplasmin as diagnostic markers for patients with chronic periodontitis in gingival crevicular fluid (GCF)
One of 10 inflammation biomarkers found in gingival crevicular fluid (GCF) that are associated with inflammation that could lead to gingivitis. The number is a quantitative, normalized ion count from a mass spectral instrument. The lower the number the less inflammation may be present. Data is after 6 weeks use of the study treatment ...
Objectives: The gingival crevicular blood (GCB) obtained during routine periodontal probing may be a source for blood glucose measurements. The aim of this study was to c..
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Background: Virulence of microorganisms contribute to initiation and progression of periodontal disease but genetic contribution to pathogenesis of periodontitis and spec..
ILs are a group of pro-inflammatory cytokines produced by fibroblast, osteoclast and polymorphonuclear leukocytes (PMNLs) and are responsible for bone turnover and remodeling process [12]. They include several markers such as IL-1β, IL-2, IL-6 and IL-8, that can be detected in crevicular fluids of the oral cavity including GCF and PMICF.. 1.1 Interleukin-1β. IL-1β is a cytokine which is produced by the IL1B gene [13]. It is a member of the interleukin-1 family of cytokines and an essential mediator of the inflammatory response. It plays an important role in various types of cellular activities, such as differentiation, cell proliferation and apoptosis, with a potential role in bone metabolism, bone resorption and inhibition of bone formation. It works through a synergistic activity with TNFs in osteoclast differentiation by RANK-RANKL binding on the osteoblast surface [13].. IL-1β is produced in a biologically inactive form that requires protease-mediated cleavage to govern its ...
Background: Periodontal diseases are microbial induced chronic inflammatory conditions characterized by infiltration of leukocytes, loss of connective tissue, alveolar bone resorption, and formation of periodontal pockets. In response to periodontal pathogens, the leukocytes (PMN) elaborate destructive oxidants, proteinases and other factors. The balance between these factors, the antioxidants and endogenously synthesized antiproteinases determine the extent of periodontal damage. Diabetes mellitus is a metabolic disorder. Most of the complications of diabetes are due to hyperglycemia. Persons with diabetes are at a greater risk for periodontal disease Malnutrition is characterized by marked tissue depletion of antioxidant nutrients and impaired acute phase protein response to infections resulting in impaired healing. Diabetes mellitus also alters the micronutrient levels. Malnutrition is characterized by marked tissue depletion of antioxidant nutrients and impaired acute phase protein response ...
Abstract: ABSTRACT, ABSTRACT Background The tissue destruction in periodontal diseases appears to result from a complex interplay between the pathogenic bacteria and the hosts immune and inflammatory responses. Numerous cytokines that play key roles in the pathophysiology of periodontitis can be identified and measured in gingival crevicular fluid (GCF). In the last 20 years, the Th1/Th2 paradigm... read more has represented a useful framework for the investigation of the pathogenesis of periodontal diseases. Many studies have supported the hypothesis that the balance of the cytokines regulated by the Th1 or Th2 response would determine if an inflamed gingival lesion would remain stable or would progress. Our goals are to provide additional information on the profile of Th1/Th2 responses in periodontal disease, by comparing the levels of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) in GCF, and to investigate the presence of novel cytokines, interleukin-33 (IL-33) and thymic stromal ...
What is oral fluid? Oral fluid is the liquid material collected from within the oral cavity of the mouth and is comprised of saliva (from submandibular, sublingual, and parotid glands), gingival crevicular fluid (from between teeth and gums), cellular debris, bacteria, and food residues.
Although extracellular (glycosylated) PAI-2 functions to regulate fibrinolysis, it remains unclear whether this inhibitory role is the main function of PAI-2. PAI-2 is predominantly intracellular. The secretory signal peptide of PAI-2 is relatively inefficient, perhaps by evolutionary design, as various mutations to the signal sequence can significantly enhance secretion efficiency.[6] PAI-2 is undetectable in adult plasma, and is typically only detectable during pregnancy, in myelomonocytic leukemias, or in gingival crevicular fluid; moreover, PAI-2 is a slower inhibitor than its counterpart PAI-1 by orders of magnitude (based on second order rate constants).[9] On the other hand, detailed intracellular roles for PAI-2 have not yet been conclusively established. PAI-2 is upregulated during both pregnancy and immune responses. During pregnancy, PAI-2 is particularly present in the decidua and amniotic fluid, where it may protect membranes from digestion and aid in remodeling fetal and uterine ...
i thought this was an intriguing twist of the more common meaning of metastasis, which deals with the transfer of cancerous cells to previously healthy sites. it reminds me of a Readers Digest quote that my mom had displayed above the kitchen sink, where we were all sure to see it often: "Never answer an angry word with an angry word. Its the second one that makes the quarrel ...
i thought this was an intriguing twist of the more common meaning of metastasis, which deals with the transfer of cancerous cells to previously healthy sites. it reminds me of a Readers Digest quote that my mom had displayed above the kitchen sink, where we were all sure to see it often: "Never answer an angry word with an angry word. Its the second one that makes the quarrel ...
A simple RP HPLC method for quantification of betamethasone dipropionate (BDP) in gingival crevicular fluid (GCF) has been developed and validated. GCF represents a valuable matrix for therapeutic monitoring of drugs used in the treatment of periodontal disease. The proposed method involves single step extraction for sample preparation. The calibration curve for BDP was linear over the concentration range of 0.10-2.00 μg mL-1 (R2 = 0.9971). RSD values of intra- and inter-day precision ranged 2.2-4.5 and 1.6-5.7 %, while accuracy values were higher than 96.6 and 97.0 %, respectively. The described method can be successfully applied for determination of betamethasone concentrations in GCF obtained from patients with chronic periodontitis after local treatment with BDP cream 0.5 mg g-1. ...
Aims: To assess the rate of tooth movement, anchorage loss, root resorption, and alkaline phosphatase (ALP) activity in the gingival crevicular fluid (GCF) as a marker for bone remodeling during orthodontic space closure using two different mechanisms. Methods: Space closure was completed in 20 patients with extraction of all 4 premolars. Lateral cephalograms and radio visiographs taken before (T1) and after (T2) space closure were assessed for anchorage loss and root resorption. Alkaline phosphatase levels were measured in 10 patients, which were divided into two groups of five each. Spaces were closed with a screw device in the first group and with active tie-backs in the second. Gingival crevicular fluid samples, collected at intervals, were assayed for alkaline phosphatase spectrophotometrically in each patient. Results: The mean rate of tooth movement was 1.32 0.22 mm/month. The mean amount of anchorage loss in the maxilla and mandible was 1.23 0.60 mm and 1.08 0.65 mm, respectively. Sixty ...
|i|Background/Purpose. |/i|Chronic periodontitis is an inflammatory disease of gums that causes loss of supporting structures of teeth, that is, gingiva, periodontal ligament, cementum, and alveolar bone. Levels of various cytokines in the serum, gingival tissues, and gingival crevicular fluid in patients with chronic periodontitis have been studied, but limited data are available on the level of cytokines in saliva. Therefore, a study was designed to determine levels of salivary IL-6 and IL-17 in patients with calculus associated chronic periodontitis.|i| Materials and Methods.|/i| It was a comparative, cross-sectional study that is comprised of 41 healthy controls and 41 calculus associated chronic periodontitis patients (CP patients). According to the degree of attachment loss, CP patients were subcategorized as mild (CAL 1-2 mm), moderate (CAL 3-4 mm), and severe (CAL > 5 mm) forms of periodontitis. Salivary levels of IL-6 and IL-17 were determined using enzyme-linked
Periodontitis is a chronic inflammatory disease characterized by destruction of periodontal tissue ultimately leading to bone destruction and has been associated with other inflammatory diseases, such as atherosclerosis. Attachment loss of periodontal tissue is primarily caused by host cell-derived immune responses against subgingival biofilm. The aim of the present study was to determine the cytokine profile in serum, saliva and gingival crevicular fluid (GCF) patients with periodontitis and healthy controls. We show that periodontitis patients exhibit higher numbers of periodontal pathogens and their immune responses are significantly altered. The levels of IL-6 in saliva and GCF were significantly suppressed, and while CXCL8 was not altered in serum, its expression levels were significantly suppressed in saliva and elevated in GCF. The T-cell-derived cytokine IL-2 did not differ between patients and controls in serum and saliva, but there was a significant suppression in GCF of patients. ...
BACKGROUND: The temporary anchorage devices (TADs) which include miniscrew implants (MSIs) have evolved as useful armamentarium in the management of severe malocclusions and assist in complex tooth movements. Although a multitude of factors is responsible for the primary and secondary stability of miniscrew implants, contemporary research highlights the importance of biological interface of MSI with bone and soft tissue in augmenting the success of implants. The inflammation and remodeling associated with MSI insertion or loading are reflected through biomarkers in peri-miniscrew implant crevicular fluid (PMICF) which is analogous to the gingival crevicular fluid ...
12. Ngan P, Wilson S, Shanfeld J, Amin i H. The effect of ibuprofen on the level of discomfort in patients undergoing orthodontic treatment. American Journal of Orthodontics and Dentof acial Orthopedics 1994;106:88-95. 13. Patel S, McGorray S, Yezierski R, Fillingim R, Logan H, Wheeler TT. Effects of analgesics on preand postseparator pai n. Masters thesis University of Florida 2008. 14. Sergl HG, Klages U, Zentner A. Pain and discomfort during orthodontic treatment: causative factors and effects on compliance. American Journal of Orthodontics and Dentofac ial Orthopedics 1998;114:684-691. 15. Krishnan V. Orthodontic pain: from cause to management a review. European Journal of Orthodontics 2007;29:170-179. 16. Giannopoulou C, Dudic A, Kiliaridis S. Pain discomfort and crevicular fluid changes induced by orthodontic elastic separators in children. The Journal of Pain 2006;7:367-376. 17. Dudic A, Kiliaridis S, Mombelli A, Giannopoulou C. Composition changes in gingival crevicular fluid dur ing ...
Background: Pedicle screws are often used to stabilise the spine. They afford the benefit of a three-column control of the spine. The technique of pedicle screw insertion is familiar and has a well-documented safety profile during lumbar and thoracic spinal surgery. However, complications such as cerebrospinal fluid leakage due to pedicle screw misplacement, neurological irritation and pedicle penetration may occur. Therefore, knowledge of the dimensions of spinal pedicles is necessary for the fixation of pedicular screws to avoid possible complications. Aims: The aim of this study was to determine the maximal diameter and axial length of thoracic and lumbar pedicles in a homogenous African population using computed tomography (CT). This would establish normative data on the average size of pedicle screws that would be required during the surgery, hence maximising pull-out strength while reducing the possibility of revision of the pedicle screw placement. Methods: It is a retrospective study ...
Methods and Materials: For Aim 1, different magnitudes (0 to 100 cN) of constant, continuous force were applied on the maxillary first molar of Sprague Dawley rats. The maxillae were collected for RNA and protein analysis, immunohistochemistry, and micro CT at different time points. For Aim 2, human subjects in different age groups (age 11-14 and 21-45) were recruited. Canine retraction was rendered with a constant force of 50 cN, and gingival crevicular fluid (GCF) was collected at different time points up to 28 days after retraction. The activity of inflammatory markers in GCF including IL-1β, CCL2, TNF-α, RANKL, and MMP-9 were measured using protein arrays. The rate of canine retraction in 28 and 56 days was measured on study models. For Aim 3, human subjects in different age groups (same as Aim 2) were recruited. Each subject in both age groups was randomly assigned to receive certain magnitude of constant force (50 to 200 cN) for canine retraction. The activity of different inflammatory ...
Root resorption is an unwanted effect of orthodontic tooth movement. Analysis of dentine proteins in gingival crevicular fluid (GCF) is a potentially safer method of quantifying root resorption compared with conventional radiographic methods. This study aimed to identify and quantify the dentine-specific matrix protein, dentine sialoprotein (DSP), released into GCF during physiological root resorption and orthodontic tooth movement. GCF was collected using micropipettes from 50 second primary molar sites undergoing physiological root resorption in 9- to 14-year olds [coronal group (Rc) with advanced resorption (n = 33) and apical group (Ra) with minimal resorption (n = 17)] and 20 subjects aged 8-14 years with erupted mandibular second premolars (control group). In addition, GCF was collected from 20 patients undergoing treatment with fixed appliances at two time points, immediately prior to orthodontic intervention (T0) and 12 weeks following commencement of fixed appliance therapy (T1). GCF ...
Aim. Probiotic bacteria have been introduced for prevention and treatment of periodontal diseases. The aim was to assess if daily oral administration of probiotic bacteria could influence the inflammatory response and the composition of supragingival plaque in an experimental gingivitis model. Materials and methods. Eighteen healthy female adults volunteered after informed consent. A double-blind randomized placebo-controlled cross-over design was used. The buccal surface of first molars was used as experimental sites. A mouth-guard covering the first premolar to second molar was used when brushing, preventing accidental cleaning during 3 weeks of plaque accumulation. Lozenges containing L. reuteri (ATCC55730 and ATCC PTA5289) or placebo were taken twice a day. During the run-in and washout periods, professional tooth cleaning was performed 5 days/week. At baseline and follow-up, plaque index, gingival index and bleeding on probing were recorded. Samples of gingival crevicular fluid (GCF) were ...
Chronic periodontitis is strongly associated with composition of the oral biofilm occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative, red complex bacteria instigate periodontal bone loss in patients, principal among these Porphyromonas gingivalis. P. gingivalis is a late colonizer, indicating not only its physical location within the oral biofilm, but also the pathogenic dynamic of the interaction between P. gingivalis and the host innate immunity. Among several other subversive tactics, P. gingivalis has been shown to compel receptors vital to the orchestration of an appropriate immune response to co-associate and consequently signal in a way that directly benefits the pathogen. Upon interaction with human monocytes and murine macrophages, P. gingivalis has been shown to induce TLR2 and CXCR4 to co- associate in lipid rafts via its surface fimbriae. The ensuing crosstalk results in a cAMP dependent, PKA mediated inhibition of NF-KB which in turn leads
Metabolon, Inc., the leader in metabolomics-driven biomarker discovery and analysis, today announced a new study has been published identifying biomarkers for periodontitis and gingivitis. Co-authored by scientists at Colgate-Palmolive, The Forsyth Institute and Metabolon, the paper, "Acceleration of Purine Degradation Pathway by Periodontal Disease", appears in the Journal of Dental Research (Volume 88, No. 9, 851-855 (September 2009)). Using Metabolons biochemical profiling technology, mechanistically-linked biomarkers were discovered and validated from the crevicular fluid of patients suffering from periodontitis and gingivitis. Several hundred biochemicals were identified in a few microliters of the crevicular fluid found between the tooth and gums. The biomarkers suggest that the diseases are mediated by enhanced purine degradation, a biochemical pathway associated with reactive oxygen species production and cellular inflammation. ...
Download Free Full-Text of an article EVALUATING SALIVARY ALKALINE PHOSPHATASE LEVELS AS A BIOCHEMICAL MARKER OF PERIODONTAL DISEASE IN PERIODONTAL PATIENTS IN A TERTIARY HOSPITAL IN NIGERIA
BACKGROUND AND OBJECTIVE Neutrophils are the primary white blood cells that are recruited to fight the initial phases of microbial infections. While healthy norms have been determined for circulating blood neutrophil counts in order to identify patients with suspected systemic infections, the levels of oral neutrophils (oPMNs) in oral health and in the presence of periodontal diseases have not been described. It is important to address this deficiency in our knowledge as neutrophils are the primary immune cell present in the crevicular fluid and oral environment and previous work has suggested that they may be good indicators of overall oral inflammation and periodontal disease severity. The objective of this study was to measure oPMN counts obtained in a standardized oral rinse from healthy patients and from those with chronic periodontal disease in order to determine if oPMN levels have clinical relevance as markers of periodontal inflammation. A parallel goal of this investigation was to introduce
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The effectiveness of local delivery of ofloxacin using controlled-release strips (PT-01) in periodontal patients. Part 1. PT-01 application among treatment plans for periodontal disease.:Part 1. PT-01 Application among Treatment Plans for Periodontal Disease (1989 ...
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Kit Component:- KN306359G1, Gcfc2 gRNA vector 1 in pCas-Guide vector- KN306359G2, Gcfc2 gRNA vector 2 in pCas-Guide vector- KN306359D, donor vector…
北美電信業者要求終端通訊供應商,於實體LTE網路上使用LTE裝置前,先進行其所制定的認證測試,希冀此認證能提供領先市場上最穩定的高速無線應用。其中因GCF和PTCRB測項已可提供各自的一致性驗證,故亦被納入電信系統業者認證測試項目中。
lub and colleagues in the 1980s, Golub and others further studied the influence of SDD on the host response on a molecular level.. In 1997, Golub and colleagues26 studied whether SDD administration to a population of patients with chronic periodontitis would reduce the amount of specific collagenases and bone-type collagen degradation fragments in gingival crevicular fluid (GCF). Their study design included SRP in 18 subjects with chronic periodontitis, 12 of which received an adjunctive treatment with 20mg bid doxycycline. Both groups were followed up for a period of two months. A significant reduction in neutrophil-type collagenase (MMP-8) and MMP-13, which is associated with bone resorption, as well as a significant (p,0.05) reduction in collagen degradation fragments, was observed. The authors acknowledged that for the first time, in human studies, a reduction of MMP activity was detected with concomitant reduction in levels of collagen degradation fragments.. In a more recent study Choi et ...
Traxodent® has a convenient delivery system with no cumbersome and expensive guns or cartridges - ergonomic disposable syringe and bendable syringe tip provides excellent reach. The sleek syringe with bendable tip permits easy application. Each syringe is packaged in resealable foil pouches providing maximum freshness. Quick effective retraction: About 2 minutes - no fumbling with hemostatic solutions. Traxodent® provides a superior hemostasis, stopping bleeding and crevicular seepage while retraction occurs, and easily absorbs excess crevicular fluid. Aluminum chloride creates an astringent effect without irritating or discoloring surrounding tissue ...
Csillag M, Nyiri G, Vag J, Fazekas A: Dose-related effects of epinephrine on human gingival blood flow and crevicular fluid production used as a soaking solution for chemo-mechanical tissue retraction, JOURNAL OF PROSTHETIC DENTISTRY 97: (1) pp. 6-11 ...
When diagnosing a case of Ebola, time is of the essence. However, existing diagnostic tests take at least a day or two to yield results, preventing health care workers from quickly determining whether a patient needs immediate treatment and isolation.A new test from MIT researchers could change that: The device, a simple paper strip similar to a pregnancy test, can rapidly
Columbus, Ohio Oral fluid drug testing provides fast results when you require immediate alcohol detection at your business. Lab and on-site testing available. Local assistance from ARCpoint Labs of Columbus Metro area (614) 929-2770.
As there is no longer a remainder, 13 is the greatest common factor (GCF) of 897 and 481.. This version of Euclids algorithm is an efficient way to compute the GCF of two numbers. In fact, the number of steps required never exceeds five times the number of digits in the smaller integer. This was proved by French mathematician Gabriel Lamé in 1844 using the Fibonacci sequence.. To see how Lamé did it, lets consider a general case where we are trying to find the GCF of two numbers s and t where s , t.. We can say that:. ...
What is the heart rate? To answer this question, determine the time between two QRS complexes. Previously, the ECG was printed on a paper strip transported through an ECG writer at the speed of 25 mm/second. Now, digital ECGs are common; however, the method for determining the frequency remains the same. The ECG has a grid with thick lines 5 mm apart (= 0,20 second) and thin lines 1 mm (0,04 second). There are three simple methods to determine the heart rate (HR) ...
All rapid drug tests are single-step, qualitative immunoassay for the detection of drugs in urine and oral fluids. All products are manufactured in the U.S.A.
台灣台北- Anritsu將於2011年2月14日至17日參加Mobile World Congress展覽,本次Anritsu將展出LTE FDD與TDD相關測試系統,包括ME7873L、ME7832L及MT8820C等,Anritsu是唯一在RF與Protocol一致性測試設備中,達到GCF所要求的80% 一致性測試目標的測試設備廠商,其中ME7873L及ME7832L皆通過GCF認證,分別符合規定的3GPP LTE Protocol、LTE RF一致性測試系統;MT8820C則是涵蓋2G、3G到4G(LTE FDD/TDD)所有3GPP規範的all-in-one RF通訊測試系統,同時支援 LTE IP層數據傳輸速度的驗證。其他還有更多展出的優異測試系統,將在Mobile World Congress與您見面,我們誠摯地邀請您於展出期間蒞臨Anritsu攤位一館1B31指導參觀!. *如何找到安立知攤位:. http://e.mymwc.zerista.com/viewer/2674?facet_id=14&item_id=844012. 關於Mobile World Congress (MWC). 2011年MWC將於巴賽隆納展出,主辦大會GSMA(GSM ...
Epitope and STC Technologies, two firms concentrating in specialized oral fluids and related devices for diagnostic testing, expect to announce a stock merger valued at roughly $200 million.
Additional file 6: Table S5. of Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns
The aim of present study was to evaluate the frequency of 3 members of herpes virus family in the subgingival plaque samples from periodontal pockets and healthy sites of an aggressive periodontitis population. Fifteen subjects with aggressive periodontitis took part in this study. Subgingival plaque samples were harvested from their 3 deepest pockets and 3 healthy sites and subjected to a nested Polymerase Chain Reaction (PCR) technique to detect Human Cyto-megallo Virus (HCMV), Epstein Barr virus 1 (EBV-1) and Herpes Simplex Virus 1 (HSV-1). Seven individuals revealed HCMV in their diseased sites while only 2 of these individuals revealed HCMV at their healthy sites too. Three individuals showed EBV-1 only at their diseased sites, while the remainig diseased sites and all healthy sites were negative for this virus. Finally, HSV-1 was found only at one of the diseased samples, but none of the healthy samples. Members of the Herpesvirus family might be recovered at periodontal sites. The ...
T his i nvestigation c ompared g ingival c revicular fl uid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6-10 mm) were obtained at the baseline, 30, and 180 days. IL-1β was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1β changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1β concentrations decreased from 3.2 pg/μL to 1.9 pg/μL. Higher baseline IL-1β concentrations were associated with higher baseline PPD values in both groups. There ...
Dental restorative materials interact with their surrounding oral environment. Interaction factors can be release of toxic components and/or effects on biofilm formation and gingiva. In the end of the nineties, a calcium aluminate cement (CAC) was manufactured as a "bioceramic" alternative to resin composite. Dental ceramics are considered to be chemically stable and not to favour dental biofilm formation. Since the influence of aged, resin-bonded ceramic coverages is not fully investigated and the effect of CAC restorations on the dental biofilm formation and gingival response is unknown, those issues were evaluated in this thesis.. With or without oral hygiene, in clinical trials including cervical surfaces of CAC, and approximal surfaces of a leucite-reinforced bonded ceramic; biofilm growth, presence of caries-associated bacteria, clinical expressions of gingivitis, the amounts of gingival crevicular fluid (GCF) and its levels of IL-1α, IL-1β and IL-1 ra were investigated in comparison ...
Aim This study evaluated whether diabetes modulates gene expression [interleukin (IL)-1 beta, IL-1ra, IL-6, IL-8, IL-10; tumor necrosis factor (TNF)-alpha; interferon (IFN)-gamma, receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG)] in sites with periodontitis. Materials and Methods Gingival biopsies were harvested and divided into three groups - Control group: systemically and periodontally healthy subjects (n = 10); Periodontitis group: systemically healthy subjects diagnosed with chronic periodontitis (n = 20); Diabetes group: type 1 diabetic subjects, diagnosed with chronic periodontitis (n = 20). Total RNA was obtained and analyzed by quantitative polymerase chain reaction. Results Data analysis demonstrated that, except for OPG, mRNA levels for all factors were increased by inflammation (P , 0.001). Interleukin-1 beta, IL-1ra, IL-6, IL-8, IFN-gamma, and RANKL mRNA levels were higher in the diabetic group when compared with the control non-periodontitis group (P , ...
A hand-held printing calculator for printing calculating results on elongated paper strips from a bundle of paper strips disposed within the calculator is provided. The calculator includes a microprinter having a paper feeding assembly including feeding elements disposed before and after the print position and in the same plane as the advancing paper for maintaining the paper flat during printing. In another embodiment of the invention, a detection sensor detects the absence of a paper strip at the print position for generating a signal for feeding the next paper strip so that paper is continuously fed to the print position.
Many studies have looked at the link between periodontitis and heart disease. While there is not enough evidence to say that periodontitis causes hear
STUDY DESIGN:. The intervention is designed as a multi-center, randomized, controlled, clinical trial to determine the effects of periodontal therapy on the rate of preterm birth. Study participants will be assigned to one of two study arms. All pregnant women who present to the designated Obstetrical (OB) clinics are potential subjects for this study. A total of 1800 patients will be enrolled at 3 performance sites, enrolling about 600 subjects at each site at a rate of about 171 subjects/year at each site, randomly assigning these subjects to one of 2 treatment arms. Randomization will be performed using a computer-generated assignment scheme designed and performed in a masked manner by the data coordinating center. Each performance site will enroll about 300 subjects into each treatment group using the intent-to-treat principle, obtaining follow-up on all subjects. In treatment Group 1 participants will be assigned to standard localized periodontal therapy of scaling and root planning with ...