PRIMARY OBJECTIVES:. I. To test the hypothesis that treatment with multi-day methotrexate is inferior to treatment with pulse actinomycin-D (dactinomycin) in patients with low-risk gestational trophoblastic disease with respect to complete response.. SECONDARY OBJECTIVES:. I. To describe the frequency of post protocol surgical treatment for each arm. II. To describe the frequency of post protocol multi-agent chemotherapy treatment for each arm.. III. To compare multi-day methotrexate to actinomycin-D with respect to frequency and severity of adverse events in patients with low-risk gestational trophoblastic neoplasia.. IV. To investigate the impact of treatment on overall quality-of-life (QOL) and explore the influence of treatment on issues such as body image, sexual functioning, and patient-reported side effects and disruption.. V. To assess whether uterine artery pulsatility index (UAPI) can provide independent prognostic information predictive of single-drug resistance.. OUTLINE: Patients ...
Uncorrected OCR) Abstract of thesis entitled GENE EXPRESSION PROFILE IN HUMAN TROPHOBLAST AND GESTATIONAL TROPHOBLASTIC DISEASE submitted by Feng Hui-Chen for the degree of Doctor of Philosophy at the University of Hong Kong in August 2004 Trophoblast in normal placenta is pseudo-malignant in nature. Neoplastic transformation of trophoblast leads to gestational trophoblastic diseases (GTD). Choriocarcinoma (CCA) and hydatidiform mole (HM) are major types of GTD. Generally GTD shows varying potential for local invasion and metastasis, but responds well to chemotherapy. The major problem in the treatment of GTD is the delay of chemotherapy particularly in highly malignant cases. Identification of predictive molecular markers may improve the early diagnosis for malignant GTD. In this study, both trophoblastic cell lines and clinical tissues were used in the examination of differentially expressed genes using various approaches. Their gene expression profiles were used in the identification of ...
Gestational trophoblastic disease (GTD) is a group of rare diseases in which abnormal trophoblast cells grow inside the uterus after conception. In gestational trophoblastic disease (GTD), a tumor develops inside the uterus from tissue that forms after conception (the joining of sperm and egg). This tissue is made of...
Doppler ultrasonography can be used to assess neoangiogenesis, a characteristic feature of postmolar gestational trophoblastic neoplasia. However, there is limited information on whether uterine artery Doppler flow velocimetry parameters can predict gestational trophoblastic neoplasia following a complete hydatidiform mole. The purpose of this study was as follows: 1) to compare uterine blood flow before and after complete mole evacuation between women who developed postmolar gestational trophoblastic neoplasia and those who achieved spontaneous remission, 2) to assess the usefulness of uterine Doppler parameters as predictors of postmolar gestational trophoblastic neoplasia and to determine the best parameters and cutoff values for predicting postmolar gestational trophoblastic neoplasia. ...
Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. These tumours are rare, and they appear when cells in the womb start to proliferate uncontrollably. The cells that form gestational trophoblastic tumours are called trophoblasts and come from tissue that grows to form the placenta during pregnancy. There are several different types of GTD. Hydatidiform moles are benign in most cases, but sometimes may develop into invasive moles, or, in rare cases, into choriocarcinoma, which is likely to spread quickly, but which is very sensitive to chemotherapy, and has a very good prognosis. Gestational trophoblasts are of particular interest to cell biologists because, like cancer, these cells invade tissue (the uterus), but unlike cancer, they sometimes "know" when to stop.[citation needed] GTD can simulate pregnancy, because the uterus may contain fetal tissue, albeit abnormal. This tissue may grow at the same rate as a normal pregnancy, and produces chorionic ...
Risk factors for gestational trophoblastic disease include maternal age, previous molar pregnancy and history of miscarriage. Learn about GTD risk.
Gestational trophoblastic disease (GTD) is a broad term encompassing both benign and malignant growths arising from products of conception in the uterus.[1] Incidence and Mortality The reported incidence of GTD varies widely worldwide, from a low of 23 per 100,000 pregnancies (Paraguay) to a high of 1,299 per 100,000...
Treatments for gestational trophoblastic disease include surgery, chemotherapy and radiation. Learn about treatment plans and options for GTD.
In case of symptoms or an abnormal screening test, more testing can help find out if its cancer. Learn about gestational trophoblastic disease diagnosis tests here.
Completing treatment is stressful and exciting. Though relieved, it is hard not to worry about gestational trophoblastic disease recurrence. Learn more here.
If you or your loved one has been diagnosed with gestational trophoblastic disease, Memorial Sloan Kettering is ready to help. Find a doctor or clinical trial, and learn about our approach to treatment.
Gestational trophoblastic disease (GTD) includes several rare tumors that occur in the uterus and start in the cells that form the placenta during pregnancy. In 6th century, Aetius of Amida, a physician at Justinians court came up with the term hydatid. Next mention of mole is from 1276 when Margaret, Countess of Henneberg, delivered approximately 300 babies on Good Friday (the Friday before Easter Sunday). In 1827, Marie Anne Victoire Boivin, a Parisian midwife, proposed her findings of this condition in Nouvelles Recherches de la Mole Visiculaire (News Searches of the Vesicular Mole). In 1840, William Wilton reported a case of invasive mole that was complicated by uterine perforation and fatal internal hemorrhage. In 1867, Richard von Volkmann, a German surgeon, also described a lesion resembling an invasive mole. In 1877, Hans Chiari, an Austrian pathologist, reported three cases of choriocarcinoma. He recognized the tumors as epithelial. In 1888, Max Sanger, a German obstetrician, ...
Gestation trophoblastic disease is a rare condition that arises out of an abnormal pregnancy in which a tumor develops in the cells and tissue that form the placenta, preventing the embryo from developing normally. If benign, the tumor is generally called a molar pregnancy. In rare cases, the tumor develops into a malignancy that can invade the walls of the uterus or other organs. Dr. Sean S Tedjarati and his team treat this condition using a dilatation and curettage, which removes affected cells from the uterine walls. In some cases of persistent disease, chemotherapy or additional surgery may be required, all provided under the careful guidance of our experienced specialists. ...
in Acta Clinica Belgica (2013), 68(6), 465. Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or ... [more ▼]. Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophilic antibodies. This situation requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Observation: A 23 years old woman (GOPO status) consulted his gynaecologist because of persistent abdominal pain. She was diagnosed of having trophoblastic disease on the basis of persistently positive human chorionic gonadotropin (hCG) test (Roche Modular) results, in the absence of pregnancy. Persistent ...
in Acta Clinica Belgica (2013), 68(6), 465. Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or ... [more ▼]. Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophilic antibodies. This situation requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Observation: A 23 years old woman (GOPO status) consulted his gynaecologist because of persistent abdominal pain. She was diagnosed of having trophoblastic disease on the basis of persistently positive human chorionic gonadotropin (hCG) test (Roche Modular) results, in the absence of pregnancy. Persistent ...
Goldstein DP, Berkowitz RS. Gestational trophoblastic disease. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. AbeloffsClinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 94.. McGee J, Covens A. Gestational trophoblastic disease: hydatidiform mole, nonmetastatic and metastatic gestational trophoblastic tumor: diagnosis and management. In: Lentz GM, Lobo RA, Gershenson DM, Katz VL. Comprehensive Gynecology. 6th ed. Philadelphia, Pa: Mosby Elsevier; 2012:chap 35.. Braunstein GD. Endocrine changes in pregnancy. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 21. ...
Complete information about molar pregnancy, diagnosis, symptoms, treatment, what to expect, fertility, link to cancer, when to try for another baby
In a complete mole there is no fetal tissue. The macroscopic appearance is of multiple villi with central cavitation, giving a grape like appearance. Microscopically, there is central necrosis within atypical trophoblast.. ...
Cancer Therapy Advisor provides obsteticians and gynecologists with the latest information to correctly diagnose obgyn conditions, recommend procedures and guides. Visit often for updates and new information.
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Cancer Therapy Advisor provides obsteticians and gynecologists with the latest information to correctly diagnose obgyn conditions, recommend procedures and guides. Visit often for updates and new information.
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Background: Gestational trophoblastic disease (GTD) is an uncommon complication of pregnancy, worldwide the incidence varying between 0.5 & 0.8 cases per 1000 live births. β-hCG has been used as standard tool for monitoring the biological activity of trophoblastic diseases and as a tumour marker. The abundant vascular supply of the tumour makes Colour Doppler Ultrasound a potentially useful tool to study its clinical behaviour. Objective: To evaluate the role of uterine artery doppler in earlier prediction of resolution in post molar surveillance compared to serial β-hCG follow up. Methods: A longitudinal prospective cohort study was conducted in Government Rajaji Hospital, Madurai over a period of 12 months from August 2015 to August 2016.40 cases of vesicular molewere studied andassessed before and after suction evacuation by measuring serum β-hCG level and finding its relation with Uterine ArteryResistance Index (RI). Results: Out of the forty patients,36 patients showed resolution of mole ...
Hustin, J. ; Foidart, JM. ; Philippe, E.. Distribution of Collagen-i and Collagen-iii and of Laminin in Trophoblastic Disease.In: Placenta, Vol. 7, no. 5, p. 465-465 (1986 ...
Uterine enlargement can occur in a number of situations from both diffuse and focal processes. These include: gestation related events normal intrauterine pregnancy molar pregnancy - gestational trophoblastic disease postpartum uterus - sti...
hCG is a sialoglycoprotein hormone with a molecular weight of about 36.5 kDa. hCG, together with LH, FSH and TSH, forms the glycoprotein hormone family, all of which are heterodimers that share a common 92 amino acid α--subunit. The distinct β-subunit confers biological activity and only the intact αβ-heterodimer of hCG can stimulate sex steroid production through the LH/hCG G-protein-coupled receptor. hCG is secreted by the trophoblastic placental cells and a variety of tumours. However, tiny amounts are also produced by the pituitary. hCG exists not only as the intact heterodimer but also as free subunits and an array of molecular variants that are recognised by different hCG assays to a variable degree. The rapid hCG tumour marker assay we provide is a total hCG assay that recognises all forms for which WHO protein standards have been formulated, and is used for the management of germ cell tumour (GCT) and gestational trophoblastic disease (GTD). The rapid tumour marker assay is the ...
Buy Dacilon 0.5mg Online at low price in UK, Australia,China to treat Testicular cancer, Wilms tumor, Gestational trophoblastic neoplasia. This Injection contains Dactinomycin as active ingredient.
PURPOSE: Gestational trophoblastic neoplasia (GTN) is a highly treatable disease, most often affecting young women of childbearing age. This study reviewed patients managed for GTN at the Butaro Cancer Center of Excellence (BCCOE) in Rwanda to determine initial program outcomes. PATIENTS AND METHODS: A retrospective medical record review was performed for 35 patients with GTN assessed or treated between May 1, 2012, and November 30, 2014. Stage, risk score, and low or high GTN risk category were based on International Federation of Gynecology and Obstetrics staging and the WHO scoring system and determined by beta human chorionic gonadotropin level, chest x-ray, and ultrasound per protocol guidelines for resource-limited settings ...
Were excited to share news about immunotherapies, one of the most promising treatments to emerge for gynecologic cancer. Before immunotherapies, cancer treatment included surgery, radiation, chemotherapy and hormonal therapy. Immunotherapies are showing benefits in prolonged disease control, or longer survival rates. Pembrolizumab is one of several new immunotherapies developed recently and has been approved to treat certain types of gynecologic cancers, including uterine and cervical. Pembrolizumab could provide benefit for up to 30 percent of patients with advanced endometrial cancer. Recent reports also show that some women with chemotherapy-resistant GTN (gestational trophoblastic neoplasia) respond well to immunotherapies when multiple cycles of chemotherapy have failed.. PARP inhibitors are another recent breakthrough in cancer treatment. PARP inhibitors are being developed for multiple indications, the most significant being the treatment of ovarian cancer. Experts say they are changing ...
Location: Charing Cross Hospital, London. Last Dates: 4th-5th March 2017. Registration Form. Course Schedule. FRCS (SN) revision and practice examination course.. ...
Nick Carr is a GP in St Kilda and previously an associate lecturer in the Department of General Practice at The University of Melbourne. He trained at Cambridge University and Charing Cross Hospital, London before moving to Melbourne in 1988. He completed a Masters Degree (on antibiotic prescribing for sore throat) at The University of Melbourne in1992. Nick has a long-standing interest in Quality Use of Medicines (QUM). He was QUM consultant for his Division of General Practice and is a member of the writing group for Therapeutic Guidelines - Psychotropic. He has been a member of the Pharmaceutical Health and Rational Use of Medicine (PHARM) Committee, and has also worked extensively with the National Prescribing Service. Nick has a particular interest in drug-seeking behaviour, and runs workshops on how to manage "doctor-shopping" consultations. He has published on a wide variety of subjects, from sore throats to computing, baby sleep programs, enemas, sport, fatigue, personality disorders, ...
Alfred Sangster (joint founder and Secretary) went from Cambridge to Guys and obtained the MRCP in 1876. After studying at Blackfriars he was appointed Skin Physician to Charing Cross Hospital, following a German, Hermann Beigel. Tilbury Fox had earlier been there, but for only two years.. J Herbert Stowers (joint founder and Secretary) moved from assisting Dyce Duckworth into the city as no post seemed forthcoming for him at Barts. Energetic and a good mixer, he supported both editors in the early days of the Journal and proved to be the arch-conciliator at St Johns during the struggles over the very survival of the London School of Dermatology.. W H Allchin practised in Wimpole Street and lectured at Westminster Hospital Medical School.. William Morant Baker, a general surgeon and lecturer in physiology at St Bartholomews Hospital, took over the skin patients after Dyce Duckworth. He reported an inflammatory eruption on the hand seen in the meat porters of Smithfield market, this he termed ...
Dr Arun Bhaskar MBBS MSc FRCA FFPMRCA FFICM FIPP EDPM, Consultant in Pain Medicine, Anaesthesia and Intensive care is the current President of the British Pain Society. He is also the Hon. Secretary of the Neuromodulation Society of UK and Ireland. Dr Bhaskar is also the present Chairman of the UK Section, World Institute of Pain. Dr Bhaskar advises NICE on interventional procedures, cancer pain and was a co-opted member of the GDG for Care of the Dying. Dr Bhaskar is currently the Co-chair of the Committee for the Cancer Pain Management Guidelines; he is also the Co-chair of the Neuromodulation Guidelines Committee. Dr Bhaskar is the Head of Service at the Pain Management Centre, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London and has special interests in complex pain, including cancer pain, neuropathic pain, visceral & pelvic pain, pain interventional procedures and neuromodulation. He has also a specific interest in opioid management in complicated cancer pain, as well ...
I had been told it wasnt a very nice experience, and I can now agree wholeheartedly with that. It is very uncomfortable, physically. But on the other hand, in every respect where they can make it less horrible, they do (or at least Charing Cross Hospital in Hammersmith do). I had the chance to choose an appointment date and time that suited me. When I arrived, I was seen promptly (I had taken a book and a bottle of water and was expecting a long wait, but I was into the screening room on the dot of three oclock). The radiologist was female, and was friendly, kindly, sympathetic and chatty - yet at the same time she also managed to be unintrusive and decorous. That cant be easy when you spend your working day handling other womens tits like so many slices of steak to be tenderised. She was gentle, she primed me for what the machine would feel like, and gave me tips on what I could do to minimise the discomfort (basically, relax, keep breathing, keep still, and dont hunch your shoulders ...
Synthroid - Late Lecturer on Psychologic Medicine at Charing Cross Hospital Medical School, London; and Physician tothe Hospital for Epilepsy and Paralysis, London.
A minor operation under general anaesthetic where the opening to the uterus (womb) is dilated (enlarged) and the lining of the uterus is scraped using a sharp instrument called a curette. If used in early pregnancy it will be called Evacuation of Retain ...
New show WAG! The Musical at the Charing Cross Theatre features a strong ensemble but ultimately is a triumph of style over substance, says Mel West - 25 Jul 2013 by WhatsOnStage Reviewer in Reviews. Tags: Charing Cross Theatre, WAG! The Musical
Objetivo: Comparar características clínicas e resultados de gestações múltipla com mola completa e feto normal coexistente (MHCFC) no New England Trophoblastic Disease Center (NETDC) e em centros de doença...
Detailed Dinoprostone Topical dosage information for adults. Includes dosages for Abortion, Labor Induction and Trophoblastic Disease; plus renal, liver and dialysis adjustments.
Similar to the Main Programme sessions, the panel of the CX Edited Live Cases will include a chairman, the operator in the Edited Live Case, the phycisian who will be explaining it to the audience and two invited discussants. The speaker will present the case including patient characteristics, reason for the procedure, the necessary investigation undertaken (eg. X-rays), the choice of devices available, the strategies of treatment proposed and all of the pitfalls and concerns raised before the procedure. After this presentation, a 10-minute edited video will be presented. In order to allow room for discussion about a specific technique the video could be stopped-this is an added benefit you could not have in a live case presentation. This approach will help to improve the educational basis of this session. After that, the aim will be to engage the audience in discussion.. Delegates will also have the opportunity to see these cases post Charing Cross 2015 from a video library that will be created ...
ectascy XTD -----Charing Cross -----Tonbridge -----Dover XTE -----Cross-Track Error XTF -----Experimental Transport Grumman Aircraft XTG -----External
... was educated in the UK and attended Charing Cross and Westminster Medical School. He completed his PhD at Imperial College, London. He currently leads a basic science research group investigating molecular mechanisms involved in the regulation of vascular endothelial cytoprotection.. ...
benefit. Health and Comfort in House Building ; or, Ventilation with warm air by self-acting auction power ; with review of the mode of calculating the...some actual experiments. By J. DRYSDALE, MD, and JW HAYWARD, MD London : E. & F. W. Spon, Charing Cross. Pp. 116. WE are precluded from criticism on this ...
Although...hang on a minute...that departure board is clearly not at Paddington. Hayes? Ashford? I smell Charing Cross. And you, sir, are a charlatan ...
We would be remiss if we didnt mention any of the dozens of different options out there for working in the GTD system, all of varying prices. One popular option is Things, which also has iPad and iPhone versions (but still no over-the-air syncing ability available to OmniFocus users). Theres also Firetask (which we recently reviewed), along with the seemingly forever-beta The Hit List . So why choose OmniFocus over these options?. OmniFocus is both powerful and simple at the same time. You can have tasks nested within tasks if necessary, making it easy to organize your system similar to a file hierarchy. But its also basic enough to just get the job done, and do the bare minimum.. Its all about flexibility and ease of use. And if your GTD system isnt easy to use, then you wont use it. OmniFocus is by far and away the most faithful representation of this methodology in software format.. ...
After the diagnosis of complete or partial hydatidiform mole is made or suspected, the uterine contents are removed by dilation and evacuation (D&E). Hysterectomy may be advisable in older patients who have completed childbearing to reduce the risk of malignancy. After the uterus is emptied, testing for human chorionic gonadotropin should be performed every week in order to determine if the molar pregnancy is malignant. If the molar pregnancy is benign the hormone level will become undetectable in 8-12 weeks. Hormone testing should be continued until three weekly negative levels are obtained, then followed by monthly tests for six months, after which pregnancy is permitted. During the six month follow-up it is important to avoid pregnancy. The use of oral contraceptives is safe.. A rise in the hormone level indicates that the molar pregnancy is malignant GTD (also called gestational trophoblastic neoplasia, GTN). More tests will be done to find out if the cancer has spread from the uterus to ...
HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocarcinoma. The aim of the study is to investigate the expression of HtrA1 in these gestational trophoblastic diseases and evaluate whether different HtrA1 expression might be associated with increasingly severe forms of disease. We used immunohistochemistry to assess the expression of HtrA1 in normal human placenta, hydatidiform mole (partial and complete) and choriocarcinoma. In addition to that we used the western blotting technique to quantify HtrA1 immunoreaction in normal human placentas. The most striking finding of our investigation is the decrease in immunostaining of this protease with increasing severity of gestational trophoblastic disease. For instance, in partial and ...
Molar pregnancy is an abnormal form of pregnancy in which a non-viable fertilized egg implants in the uterus and will fail to come to term. A molar pregnancy is a gestational trophoblastic disease which grows into a mass in the uterus that has swollen chorionic villi. These villi grow in clusters that resemble grapes. A molar pregnancy can develop when a fertilized egg does not contain an original maternal nucleus. The products of conception may or may not contain fetal tissue. It is characterized by the presence of a hydatidiform mole (or hydatid mole, mola hydatidosa). Molar pregnancies are categorized as partial moles or complete moles, with the word mole being used to denote simply a clump of growing tissue, or a growth. A complete mole is caused by a single sperm (incidence is about 90%) or two (incidence is about 10%) sperms combining with an egg which has lost its DNA (in the first case the sperm then reduplicates forming a "complete" 46 chromosome set). The genotype is typically 46,XX ...
Recently the news anchor, Michelle Valez, took to her instagram and shared her story of Molar pregnancy. She let her followers know that she was suffering from a rare condition of Molar pregnancy. It is a type of pregnancy that is false, and in this case, there is abnormality of the placenta. And it is caused by an issue during fertilization, according to the American Pregnancy Association. There is also another name for it- gestational trophoblastic disease. It is extremely rare and occurs in about 1 out of every 1,000 pregnancies.. Michelle Valez posted on her instagram about her issues. She explained how she had been sick for the past few months but wasnt sure what was wrong with her. And she admitted that, she was devastated when she heard about the news.. She also explained to her followers the concept of Molar pregnancy. It is a case where she wasnt pregnant but the placental tissues grew, which set off her pregnancy hormones. She also said that she felt like she was pregnant with five ...
MYOMETRIUM. Leiomoyoma and variants, leiomyosarcoma, endometrial stromal sarcoma. OVARY: Functional cysts, epithelial ovarian tumors, variants, grading and staging germ cell tumors, tumors of the stroma and sex cords. PLACENTA. Gestational trophoblastic disease: hydatiform mole, complete and partial, invasive mole, choriocarcinoma, trophoblastic tumor of the implantation site. Placental diseases: infections, twin gestations, placental malformations, vascular disorders. BREAST. Infections, ductal ectasia, fibro-cystic changes, non prliferative, proliferative and atypical. Tumors: fibroadenoma, papilloma, filloid tumor, carcinoma insitu and invasive, variants, grading and staging. Male breast: gynecomastia and carcinoma. KIDNEY: primary epithelial tumors, variants, grading and staging, pediatric tumors including Wilms tumor, angiomyolipoma, metastases. URINARY TRACT: litiasis, inflammations, urothelial tumors and precancers, variants, grading and staging. PROSTATE: prostatitis, nodular ...