Researchers at Cold Spring Harbor Laboratory (CSHL) have discovered a new function of the bodys most important tumor-suppressing protein.. Cold Spring Harbor, NY - Researchers at Cold Spring Harbor Laboratory (CSHL) have discovered a new function of the bodys most important tumor-suppressing protein. Called p53, this protein has been called "the guardian of the genome." It normally comes to the fore when healthy cells sense damage to their DNA caused by stress, such as exposure to toxic chemicals or intense exposure to the suns UV rays. If the damage is severe, p53 can cause a cell to commit preprogrammed cell-death, or apoptosis. Mutant versions of p53 that no longer perform this vital function, on the other hand, are enablers of many different cancers.. Cancer researcher Dr. Raffaella Sordella, a CSHL Associate Professor, and colleagues, today report in Proceedings of the National Academy of Sciences the discovery of a p53 cousin they call p53Ψ (the Greek letter "psi"). It is a previously ...
Speakers -------- N/A 2010 Cold Spring Harbor Laboratory Meetings Meetings Axon Guidance, Synaptic Plasticity and Regeneration September 21 - 25 abs due July 2 Cold Spring Harbor Laboratory Meetings Program, 1 Bungtown Road, Cold Spring Harbor, NY 11724 Phone 516 367 8346 email [email protected] http://www.cshl.edu/meetings ...
Cold Spring Harbor Laboratory - Postdoctoral Fellow in Neuroscience - Cold Spring Harbor - A postdoctoral fellow position is available in the - Cell Career Network
DNA Sudoku pools multitude of DNA samples for sequencing in manner analogous to solving a Sudoku grid. Cold Spring Harbor, NY - A math-based game that has taken the world by storm with its ability to delight and puzzle may now be poised to revolutionize the fast-changing world of genome sequencing and the field of medical genetics, suggests a new report by a team of scientists at Cold Spring Harbor Laboratory (CSHL). The report will be published as the cover story in the July 1st issue of the journal Genome Research.. Combining a 2,000-year-old Chinese math theorem with concepts from cryptology, the CSHL scientists have devised "DNA Sudoku." The strategy allows tens of thousands of DNA samples to be combined, and their sequences-the order in which the letters of the DNA alphabet (A, T, G, and C) line up in the genome-to be determined all at once.. This achievement is in stark contrast to past approaches that allowed only a single DNA sample to be sequenced at a time. It also significantly ...
... COLD SPRING HARBOR N.Y. (Wed. Apr. 4 2007) In their native ...One of the freely available methods (A HREF http://www.cshprotocols....To test the activity of a certain gene during embryonic development m...,Cold,Spring,Harbor,Protocols,highlights,reliable,methods,for,gene,and,protein,analyses,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Health, ...Cold Spring Harbor N.Y. A constellation of different stem cell popul...Researchers at Cold Spring Harbor Laboratory (CSHL) led by Associate P...When cells in the skin or anywhere else in the body sense a potentiall... Unfortunately there are a number of genetic events that can bypass se...,CSHL,study,unmasks,a,stem,cell,origin,of,skin,cancer,and,the,genetic,roots,of,malignancy,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Health, ... COLD SPRING HARBOR N.Y. (Tues. Dec. 2 2008) The complexity ... Bone Marrow-Derived Macrophages (BMM): Isolation and Applications f...Primary cultures of granule neurons from the cerebellum provide an exc...,Cold,Spring,Harbor,Protocols,features,tissue,culture,methods,for,immune,cells,and,neurons,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Find bipolar disorder therapists, psychologists and bipolar disorder counselors in Cold Spring Harbor, New York. Search now for detailed listings and contact a bipolar disorder therapist in Cold Spring Harbor that fits your needs!
Cold Spring Harbor Laboratory - Founded in 1890, CSHL is a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, and bioinformatics and a broad educational mission.
Cold Spring Harbor Laboratory - Founded in 1890, CSHL is a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, and bioinformatics and a broad educational mission.
COLD SPRING HARBOR, N.Y. (Sept. 4, 2008) - A variety of organisms-from bacteria and fungi to plants and animals-have biological rhythms, where the timing and duration of fundamental biological processes is naturally adjusted to allow them to adapt and survive, even under fluctuating environmental conditions. In recent years, significant advances have been made to understand the molecular basis of these rhythms and how they translate into modifications in cellular physiology and organismal behavior.. A new book from Cold Spring Harbor Laboratory Press, Clocks and Rhythms, reviews the latest advances in biological clocks and rhythms across a broad range of species and biological disciplines. Chapters in the book are based on presentations by world-renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology at Cold Spring Harbor Laboratory, which was attended by 316 scientists from more than 20 countries.. "Since the discovery and cloning of the first clock gene, ...
Written and edited by experts in the field, Malaria: Biology in the Era of Eradication, from Cold Spring Harbor Laboratory Press, explores recent developments in our understanding of malaria biology and their potential to influence malaria elimination/eradication strategies. The authors describe recent developments in their respective research areas and suggest both how these insights could guide intervention strategy and where critical knowledge gaps remain.
CSHL Press publishes monographs, technical manuals, handbooks, review volumes, conference proceedings, scholarly journals and videotapes. These examine important topics in molecular biology, genetics, development, virology, neurobiology, immunology and cancer biology. Manuscripts for books and for journal publication are invited from scientists world wide.
As one of New Yorks leading research institutions, Cold Spring Harbor Laboratory is an asset of particular value to New York State. In order to promote a clearer understanding of the multiple ways in which the Laboratory contributes to the life of New York State and its people, CSHL President & CEO Bruce Stillman, Ph.D. asked Appleseed -- a New York City-based economic development consulting firm -- to assess the Labs impact on the states economy -- and in particular, on the economy of Long Island. This report presents the results of Appleseeds analysis. Part Two highlights the impact of CSHL as an enterprise -- as an employer, a buyer of goods and services from New York companies and a sponsor of construction projects. Part Three explores several ways in which research conducted at CSHL contributes to the growth of the states and the regions economy. Part Four of the report describes CSHLs Meetings and Courses Program, which each year brings thousands of the worlds leading scientists to
Browse stories and reviews on Anobii of Biosupplynet Laboratory Research Notebook written by , published by Cold Spring Harbor Laboratory Press,U.S. in format Paperback
Students explore illuminating new ways to use fruit fly larvae for neural research at the Drosophila Neurobiology course, at the prestigious Cold Spring Harbor Laboratory.
Book now at Grassos in Cold Spring Harbor, NY. Explore menu, see photos and read 1111 reviews: Consistently outstanding across the board from every staff member to every dish I have ever eaten here! The music and ambiance complete the package.
Tom Kucharski from the Teodoro Lab presented a talk at the recent cell cycle meeting at Cold Spring Harbor Laboratory entitled: 53BP1 is a novel anaphase promoting complex/cyclosome mitotic substrate and regulator
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Fachartikel, Fachpublikationen und wissenschaftliche Papers aus den Journals der Branche: Hier finden Sie Abstracts und Literaturangaben der aktuellen Veröffentlichungen von Cold Spring Harbor Laboratory Press.
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Because NGS datasets are very large, it is often impossible or inefficient to read them entirely into a computers memory when searching for a specific piece of data. In order to more quickly retrieve the data we are interested in analyzing or viewing, most programs have a way of treating these data files as databases. Database indexes enable one to rapidly pull specific subsets of the data from them.. The Integrative Genomics Viewer is a program for reading several types of indexed database information, including mapped reads and variant calls, and displaying them on a reference genome. It is invaluable as a tool for viewing and interpreting the raw data of many NGS data analysis pipelines. ...
The Mission of HL7 Clinical Genomics Work Group The HL7 Clinical Genomics Work Group (CGWG) supports the HL7 mission to create and promote its standards by enabling the communication between interested parties of clinical and genomic data related to an individual. The focus of the CGWG efforts is the personalization of the genomic data - the so-call omics differences in an individuals genomic - and its association with relevant phenotypic and clinical information. Associations to interpretive/expected phenotypes will be modeled as knowledge that can be utilized to transform an individuals data into meaningful information. CGWG will facilitate the development of common standards for clinical research information management across a variety of organizations -- including national and international government agencies and regulatory bodies, private research efforts, and sponsored research -- and thus the availability of safe and effective therapies by improving the processes and efficiencies associated
International Journal of Plant Genomics is an international, peer-reviewed Open Access journal that publishes novel and advanced original research results of wide interest in all fields of plant genomics, genome technologies and applications of genomic tools in plant breeding. In addition, the journal welcomes field review articles of general interest to plant scientists in plant genomics. Although the journal is dedicated to publish the research results in plant genomics, research articles in genomics of animals or other organisms that are of significance in advancing or potentially applicable to plant genomics are considered for publication in the journal.
Read "Transcriptome profile of the human placenta, Functional & Integrative Genomics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Kim SH, Shin DH, Liu J, Oganesyan V, Chen S, Xu QS, Kim JS, Das D, Schulze-Gahmen U, Holbrook SR, Holbrook EL, Martinez BA, Oganesyan N, DeGiovanni A, Lou Y, Henriquez M, Huang C, Jancarik J, Pufan R, Choi IC, Chandonia JM, Hou J, Gold B, Yokota H, Brenner SE, Adams PD, Kim R. 2005. Structural genomics of minimal organisms and protein fold space. J Struct Funct Genomics 6:63-70. [PubMed],[abstract] ...
Yeast Media Components. All media are formulated as described in the Cold Spring Harbor Lab Manual for Yeast Genetics, Kaiser, C., et al., Methods in Yeast Genetics, (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1994) and the Difco Manual 11th ed.. ...
Long Island Biological Association (N.Y.); Biological Laboratory (Cold Spring Harbor, N.Y.); Cold Spring Harbor Laboratory of Quantitative Biology.; Cold Spring Harbor Laboratory ...
The LIMR Chemical Genomics Center Inc., a subsidiary of Lankenau Institute for Medical Research in Wynnewood, Pa., was awarded a Grand Challenges Expl ...
Identifying functions for all gene products in all sequenced organisms is a central challenge of the post-genomic era. However, at least 30-50% of the proteins encoded by any given genome are of unknown or vaguely known function, and a large number are wrongly annotated. Many of these unknown proteins are common to prokaryotes and plants. We set out to predict and experimentally test the functions of such proteins. Our approach to functional prediction integrates comparative genomics based mainly on microbial genomes with functional genomic data from model microorganisms and post-genomic data from plants. This approach bridges the gap between automated homology-based annotations and the classical gene discovery efforts of experimentalists, and is more powerful than purely computational approaches to identifying gene-function associations. Among Arabidopsis genes, we focused on those (2,325 in total) that (i) are unique or belong to families with no more than three members, (ii) occur in prokaryotes,
FREMONT, Calif., March 26, 2015-- WaferGen Bio-systems, Inc. announced today an important industrial partnership with Procter& Gamble whereby Procter& Gamble will utilize WaferGens SmartChip MyDesign™ quantitative PCR System to conduct various gene expression and other studies. We are very pleased that, following a thorough evaluation of multiple...
The purpose of the Psychiatric Genomics Consortium (PGC) is to unite investigators around the world to conduct meta- and mega-analyses of genome-wide genomic data for psychiatric disorders. This website provides information about the organization, implementation, and results of the PGC.. The PGC began in early 2007 and has rapidly become a collaborative confederation of most investigators in the field. The PGC includes over 800 investigators from 38 countries. There are samples from more than 900,000 individuals currently in analysis, and this number is growing rapidly. The PGC is the largest consortium and the largest biological experiment in the history of psychiatry.. The PGC is passionate about open, inclusive, participatory, and democratic science. Given the importance of the problems we study, we are committed to rapid progress.. From 2007-11, the PGC focused on autism, attention-deficit hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia. We now include ...
Nearly 150 scientists and industrialists attended a recent meeting outside Cambridge to review progress in the application of genomics to crop plant improvement. The meeting covered a wide range of topics, from genome sequencing methods to marker-assisted breeding for wheat improvement. In her opening address, Julia Goodfellow (Biotechnological and Biological Sciences Research Council, Swindon, UK) described the increasing need for more healthy and nutritious food produced in environmentally sustainable ways and the need to translate the fruits of basic research in model species into crop improvement. The meeting established that such a research pipeline is a high priority and that genomics provides the means to achieve it.. Crop plants often have large and complex genomes; the maize genome, for example, is around 2.5 gigabase pairs (109 base pairs), approximately the same size as that of humans. Richard McCombie (Cold Spring Harbor Laboratory, New York, USA) described the remarkable progress ...
Once again, the summer course on Marine Ecological & Environmental Genomics (12th edition) will take place at the Station Biologique de Roscoff (France), from June 5th to June 16th 2017.. Aims. Knowledge of marine genomics knowledge is crucial for understanding the marine environment and for an efficient use of its resources. New methods have revolutionized the field, spawning applications in basic research and environmental management. The course will give insight into population, environmental, biodiversity, comparative, evolutionary and functional genomics through lectures, case studies, and computer labs.. Target group Advanced PhD students (at least in their second year) and junior postdocs with a solid knowledge in marine ecological and environmental genomics, phylogenetics and/or population genetics. ...
I use cutting-edge genomic technologies to understand the impact of human genetic variation and to understand the genetic causes of musculoskeletal disease Rare Variant Associations Since 2009, I have been working to understand the impact of rare genetics variants, both coding and non-coding on complex traits. Read more → Common Variant Associations Using genotyping microarrays and exome sequencing,…
A central problem in bioinformatics is the analysis of genomic information, leading up to the entire human genome. Research in whole genome analyses include finding genes and pseudogenes, assigning protein structures and functions to known genes, and comparing genomes in terms of a wide variety of features. Closely tied to this work is the development of computational approaches for comparing and characterizing sequences and predicting structure and function (e.g. identifying membrane proteins) from sequence. A major new development is the advent of functional genomics information with standardized experimental information over the entire genome. For example, one of the major types of functional information is genome-wide gene expression data. All members of the Track faculty are interested in the general problem of achieving an integrative and systems understanding of the whole genome.. Yale has a diverse set of activites in the areas of genomics and proteomics that are relevant to ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: NHLBI Pediatric Cardiac Genomics Consortium (U01) RFA-HL-09-003. NHLBI
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Pediatric Cardiac Genomics Consortium (UM1) RFA-HL-15-012. NHLBI
Far-reaching biological achievements, epitomized by the Human Genome Project, are the outcome of fast-growing compilations of vast and complex biological information. In order to analyze the plethora of data gathered, Biology requires the aid of computational interpretation - hence, Computational Biology.. The Computational Genomics Laboratory at Tel Aviv Universitys School of Computer Science, has been researching computational problems related to gene, protein and disease analysis. The labs research interests include gene expression analysis, modeling and dissection of molecular networks, gene regulation, genomic rearrangements and cancer genomics. The methodologies assisting the researchers in their analysis are graph theory, complexity, probability and statistics. Methods and software tools developed by the group are in use by many laboratories around the world.. The lab is supervised by: Prof. Ron Shamir.. ...
Research groupsGene regulation and morphogenesis Functional genomics studies to unravel development, evolution and human genetic diseases Dr ..
Ali Bashashati of BC Cancer Agency, Canada presents technical examples of big data problems seen in cancer genomics research. Topics includes Next-Gen sequencing (NGS), cancer genomics and more from the 2014 IEEE SPS / UBC ICICS Summer School.  More information available at: http://vancouver.ieee.ca/content/ieee-sps-ubc-icics-summer-school-signal-processing-and-machine-learning-big-data
COLD SPRING HARBOR, N.Y. (Monday, June 1, 2009) - High-throughput whole-genome analysis is becoming a standard laboratory approach for investigating cellular processes. Next-generation sequencing is replacing microarrays as the technique of choice for genome-scale analysis, because it offers advantages in both sensitivity and scale. The June issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc6_09.dtl) features Native Chromatin Preparation and Illumina/Solexa Library Construction from Keji Zhao and colleagues at the National Heart, Lung and Blood Institute (http://public.nhlbi.nih.gov/Staff/Home/UserInputForPerson.aspx?OID=895&LabId=lmi). The article describes sample preparation for sequencing of chromatin-immunoprecipitated DNA (ChIP-Seq) to analyze histone modification patterns using native chromatin and the Solexa/Illumina Genome Analyzer. Step-by-step instructions are given for purification of human CD4+ T cells from lymphocytes and chromatin fragmentation using micrococcal ...
Learn about cancer genomics with our educational videos. Clinical Genomics Testing Presented by Dr. Howard Lim, MD, FRCPC. Next generation sequencing | Availability of genomic tests nationally and internationally | Issues and challenges in genomic testing | Managing incidental germline findings
At the base of current genomics research lie the powerful technologies that continuously aim to deliver more data at lower cost. The sequencing boom has driven the creation of an assortment of new companies, as well as heavy investment from existing companies, to provide sequencing solutions, library preparation reagents and bioinformatics support. This was evidenced by the 20 or so companies represented at the meeting.. Scott Brouilette (Illumina) introduced a clever genome phasing solution based on work from Stephen Quakes lab (Howard Hughes Medical Institute, Stanford University, USA) that relies on sequencing of large DNA fragments (6 to 8 kb) aliquoted at limiting dilution. This allows for segregation of haplotypes and resolution of cases of compound heterozygosity, as well as improved assembly of repetitive regions.. Clive Brown (Oxford Nanopore, UK) provided a much-anticipated update that highlighted the technical hurdles that Oxford Nanopore has had to overcome to produce nanopore ...
UC Davis Childrens Hospital, UC Davis MIND Institute and UC Davis Comprehensive Cancer Center will host the fourth annual Human Genomics Symposium, a conference that will bring together medical experts and researchers to discuss recent advances in genomic medicine.. The symposium will take place from 9 a.m. to 4 p.m. on Friday, Nov. 17 in room 1222 of the Education Building on the Sacramento campus of UC Davis, located at 4610 X Street. The symposium is sponsored by UC Davis Health, the UC Davis Office of Continuing Medical Education (CME) and the UC Davis Division of Genomic Medicine. Physicians, nurses, physician assistants, pharmacists and veterinarians are invited to attend the free conference.. The conference aims to analyze and classify the new research and technologies applied at UC Davis, identify ways to apply translational genomics to the UC Davis Health clinical mission, and formulate and synthesize efforts for clinical practice and translational research in genomic medicine at UC ...
The conceptual and practical changes that have taken place in scientific theory and research in relation to genomics have also not yet found their place in the science curriculum, at least not in the Netherlands. It is now a few years since the publication of the human genome, and genomics research is continually generating large and complex data sets that have transformed the study of virtually all life processes (Collins, 2003). Despite this, and although a range of outreach programmes offer a temporary solution, such as the Dutch mobile DNA labs (van Mil, 2007), greater efforts are needed to embed genomics into the standard science curriculum.. Two important characteristics of genomics are immediately apparent for inclusion in new educational materials. First, genomics combines the expertise and techniques of many disciplines-for example, molecular biology, physical sciences and bioinformatics-in order to study genome-environment interactions in relation to phenomena at many biological ...
Early buyers will receive 10% customization on this report.. Until the last decade, application of genomics was restricted to academic research. With the advent of innovative technologies in DNA sequencing and gene expression, the key focus of genomics has shifted to drug discovery and agricultural research. The success of various research projects in utilizing genomic research for personalized medicine and molecular diagnostics is expected to increase the penetration of genetic testing in these application areas. Genomics-related testing also enables researchers to obtain accurate diagnosis of various life-threatening diseases. Moreover, government initiatives and notable pipeline projects on personalized medicine are expected to support this paradigm shift in the coming years.. Inquiry Before Buying: http://www.marketsandmarkets.com/Enquiry_Before_Buying.asp?id=613. The governments of several nations have made significant investments in the genomics market to promote genomics technologies in ...
Reverse genetics has been an indispensable tool revolutionising insights into viral pathogenesis and vaccine development. Large RNA virus genomes, such as from Coronaviruses, are cumbersome to clone and manipulate in E. coli due to size and occasional instability1-3. Therefore, an alternative rapid and robust reverse genetics platform for RNA viruses would benefit the research community. Here we show the full functionality of a yeast-based synthetic genomics platform to genetically reconstruct diverse RNA viruses, including members of the Coronaviridae, Flaviviridae and Paramyxoviridae families. Viral subgenomic fragments were generated using viral isolates, cloned viral DNA, clinical samples, or synthetic DNA, and reassembled in one step in Saccharomyces cerevisiae using transformation associated recombination (TAR) cloning to maintain the genome as a yeast artificial chromosome (YAC). T7-RNA polymerase has been used to generate infectious RNA to rescue viable virus. Based on this platform we have been
The Genomics Facility is one of five highly specialized laboratories in the University of Guelphs Advanced Analysis Centre. The AAC is located in the multidisciplinary Summerlee Science Complex which provides a range of capabilities for research and advanced education at the interface of the physical and biological sciences.. The Genomics Facility is designated as an Ontario Genomics Platform Affiliate, OGPA, service facility and operates as a core facility offering molecular biology technology support services and training in DNA sequencing, genotyping, and gene expression analyses to the University of Guelph as well as other academic, government and private sector institutions.. For information about the services we offer view Genomics Services. To check the current bookings view the Genomics Equipment Bookings. ...
This is to announce a new PhD position on Genomics and Bioinformatics at the School of Life Sciences in Wädenswil (Switzerland), close to the Lake of Zürich.. Your project will investigate the re-emerging plant pathogen Xanthomonas hortorum. The aim is to study genomic diversity of the different pathovars within the X. hortorum species-level clade in order to design novel diagnostic methods and to study the molecular base of host-specificity of the individual pathovars. Your work will combine microbiology, MALDI-TOF MS identification, genome sequencing, comparative genomics and innovative computer analyses. You are expected to actively shape the direction of your project and should be highly motivated, creative and curious. Your research could make a significant boost towards rapid identification and understanding of this re-emerging plant pathogen.. For more information, please consult the website ...
Recent advances in DNA sequencing, molecular cloning, and gene editing helped remarkably in understanding the biology of life forms in our nature. Reduced cost and increased speed of DNA sequencing have led to rapid growth of genomics. Functional significance of genomic elements (genes, RNA, proteins, small molecules and phenotype) are still being unravelled in many organisms. The data coming out from large-scale functional genomics studies need to be stored, analyzed and interpreted. This requires a high-end computing facility and data center to cater towards the scientific community. India being a country having the richest biodiversity hotspots in the world, there is huge scope to decode genomes, understand and harness functionality of biodiversity through functional genomics and bio-informatics approaches. Our center aim to carryout large-scale studies in relation to conservation and traditional medicine.. ...
During the past year, the field of cardiovascular genomics has witnessed publication of an unprecedented number of outstanding articles. In addition to large-scale investigations of original hypotheses (eg, pleiotropic effects of height loci on coronary artery disease [CAD]), our community has welcomed seminal functional genomics studies using gene editing, induced pluripotent stem cells (iPSC), and total RNA sequencing. Taken together, these studies have produced valuable insights into mechanisms underlying the observed associations with cardiovascular disease (CVD).. The mission of the Functional Genomics and Translational Biology (FGTB) Council of the American Heart Association (http://www.my.americanheart.org/fgtbcouncil) is to advance new discoveries in the fields of genetics, omics-based approaches, and translational biology, as well as to facilitate their application in cardiovascular health and disease. By creating a multidisciplinary collaborative environment, this Council integrates ...
Non-coding RNAs (ncRNA) are a diverse group of genes that do not encode proteins but function exclusively on the level of RNA and were originally suggested to be remnants of a pre-DNA stage of life known as the RNA world. More recent work, however, has uncovered a rich repertoire of previously unknown families with possible consequences for our understanding of the origin and evolution of the modern RNA infrastructure. The main goal of this thesis was therefore to re-examine the evolutionary history of RNAs and theories regarding the transition from an RNA world in light of recent advances in molecular and computational biology.. Using comparative genomics approaches and sequence data from all domains of life, my work shows that the majority of known RNAs exhibit a highly domain-specific distribution, compatible with an ongoing emergence rather than deep ancestry. Focusing on small nucleolar RNAs (snoRNA), I find that the eukaryote ancestor possessed a complex snoRNA infrastructure, but that ...
Citoxlab is your ideal partner for preclinical and clinical genomics studies, whether you are developing a protein, nucleic acid or cell-based therapeutic..
Sager S, Dolinsky JS, Hershberger RE. Sager S, Dolinsky J.S., Hershberger R.E. Sager, Solomon, et al.Dilated Cardiomyopathy. In: Murray MF, Babyatsky MW, Giovanni MA, Alkuraya FS, Stewart DR. Murray M.F., Babyatsky M.W., Giovanni M.A., Alkuraya F.S., Stewart D.R. Eds. Michael F. Murray, et al.eds. Clinical Genomics: Practical Applications in Adult Patient Care, 1e New York, NY: McGraw-Hill; 2014. http://accessmedicine.mhmedical.com/content.aspx?bookid=1094§ionid=61900253. Accessed December 12, 2017 ...
International Journal of Genomics is a peer-reviewed, Open Access journal that publishes research articles as well as review articles in all areas of genome-scale analysis. Topics covered by the journal include, but are not limited to: bioinformatics, clinical genomics, disease genomics, epigenomics, evolutionary genomics, functional genomics, genome engineering, and synthetic genomics.
COLD SPRING HARBOR, N.Y. (Tues., Sept. 1, 2009) - Chromatin Immunoprecipitation (ChIP) is an invaluable method for studying the interactions between proteins and DNA on a genome-wide scale. ChIP can be used to determine whether a transcription factor interacts with a candidate target gene, and is used to monitor the presence of histones with posttranslational modifications at specific genomic locations. The results are often extremely useful for investigating the functions of specific transcription factors or histone modifications. In the September issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc9_09.dtl), Michael Carey (portal.ctrl.ucla.edu/biological-chemistry/institution/personnel?personnel_id=45403), Craig Peterson (www.umassmed.edu/pmm/faculty/peterson.cfm), and Stephen Smale (dgsom.healthsciences.ucla.edu/institution/personnel?personnel_id=45693) present Chromatin Immunoprecipitation (ChIP), an optimized protocol for use in mammalian cells. The article is freely ...
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The National Genomics Center for Wildlife and Fish Conservation is a state-of-the art facility for advanced research providing expertise in DNA sequencing and environmental and forensic DNA sampling.
Read "From population genetics to population genomics of forest trees: Integrated population genomics approach, Russian Journal of Genetics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under changing environments. It stems from an integration of high throughput data from functional genomics, statistical modeling and bioinformatics, and the procedure of phylogeny-based analysis.
Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under changing environments. It stems from an integration of high throughput data from functional genomics, statistical modeling and bioinformatics, and the procedure of phylogeny-based analysis.
The growing advances in DNA sequencing tools have made analyzing the human genome cheaper and faster. While such analyses are intended to identify complex variants, related to disease susceptibility and efficacy of drug responses, they have blurred the definitions of mutation and polymorphism. In the era of personal genomics, it is critical to establish clear guidelines regarding the use of a reference genome. Nowadays DNA variants are called as differences in comparison to a reference. In a sequencing project Single Nucleotide Polymorphisms (SNPs) and DNA mutations are defined as DNA variants detectable in >1 % or <1 % of the population, respectively. The alternative use of the two terms mutation or polymorphism for the same event (a difference as compared with a reference) can lead to problems of classification. These problems can impact the accuracy of the interpretation and the functional relationship between a disease state and a genomic sequence. We propose to solve this nomenclature dilemma by
Reams, A.B. & Roth, J.R., 2015. Mechanisms of gene duplication and amplification In "DNA Recombination". Editors: Stephen Kowalczykowski, Neil Hunter, and Wolf Heyer, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.. Reams, A. B. E. Kofoid, N. Duleba, and J. R. Roth, 2014. "Recombination and annealing pathways compete for substrates in making rrn duplications in Salmonella enterica" Genetics, 196:119-135. Quiñones-Soto S., A. B. Reams, and J.R. Roth, 2012. "Pathways of genetic adaptation: Multi-step origin of mutants under selection without induced mutagenesis in Salmonella enterica" Genetics, 192:987-999.. Reams, A. B. E. Kofoid, E. Kugelberg, and J. R. Roth, 2012. "Formation of duplications by multiple pathways with and without recombination (RecA)" Genetics, 192:397-415.. Reams, A. B., E. Kofoid, M. Savageau, and J. R. Roth, 2010. "Duplication frequency in a population rapidly approaches steady state with or without recombination" Genetics, 184:1077-1094.. Roth, J. R., E. ...
TY - JOUR. T1 - Characterization of a murine cellular SV40 T antigen in SV40-transformed cells and uninfected embryonal carcinoma cells. AU - Linzer, D. I H. AU - Maltzman, W.. AU - Levine, A. J.. PY - 1979/12/1. Y1 - 1979/12/1. UR - http://www.scopus.com/inward/record.url?scp=0018692275&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018692275&partnerID=8YFLogxK. M3 - Article. C2 - 6253135. AN - SCOPUS:0018692275. VL - 44. SP - 215. EP - 224. JO - Cold Spring Harbor Symposia on Quantitative Biology. JF - Cold Spring Harbor Symposia on Quantitative Biology. SN - 0091-7451. IS - 1. ER - ...
Molecular Cloning A Laboratory Manual, 3rd ed. Joseph Sambrook and David W. Russell. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2001. 3 vols., 2288 pp. $295, £231. ISBN 0-87969-576-5. Paper, $195, £149. ISBN 0-87969-577-3.. This new edition of a classic compendium of protocols for biomolecular research is accompanied by a Web site that represents the likely future of efforts to provide researchers and students with up-to-date descriptions of reliable methods for carrying out experiments.. ...
Techniques for isolating and modifying specific nucleic acids and proteins are well known to those skilled in the art. In accordance with the present invention, conventional molecular biology, microbiology, and recombinant DNA techniques within the skill of the art can be used. Such techniques are explained fully in the literature. See, for example, Sambrook, Fritsch and Maniatis, Molecular Cloning: A Laboratory Manual, 2nd Edition, Cold Spring Harbor, N .; Y. : Cold Spring Harbor Laboratory Press, 1989 ("Sambrook et al., 1989" herein); DNA Cloning. A Practical Approach, Volume I and Volume II (D.N. Glover edit, 1985); Oligonucleotide Synthesis (M. J. Gait edit, 1984); Nucleic Acid Hybridization [B. D. Hames and S.H. J. et al. Higgins (1985)]; Transcribation And Translation [B. D. Hames and S.H. J. et al. Edited by Higgins (1984)]; Animal Cell Culture [R. I. Freshney edited (1986)]; Immobilized Cells And Enzymes [IRL Press, (1986)]; Perbal, A Practical Guide To Molecular Cloning (1984); Ausubel, ...
Although I am fully convinced of the truth of the views given in this volume, I by no means expect to convince experienced naturalists whose minds are stocked with a multitude of facts all viewed, during a long course of years, from a point of view directly opposite to mine. It is so easy to hide our ignorance under such expressions as "plan of creation," "unity of design," etc., and to think that we give an explanation when we only restate a fact. Any one whose disposition leads him to attach more weight to unexplained difficulties than to the explanation of a certain number of facts will certainly reject the theory. ...
books.google.comhttps://books.google.com/books/about/Abstracts_of_papers_presented_at_the_199.html?id=vAFKAQAAIAAJ&utm_source=gb-gplus-shareAbstracts of papers presented at the 1996 meeting on gene therapy ...
Snary, D., Ferguson, M. A. J., Allen, A. K., Miles, M. A. & Sher, A., 1985, Vaccines 85: Molecular and Chemical Basis of Resistance to Parasitic, Bacterial and Viral Diseases. Brown, F., Lerner, R. A. & Chanock, R. M. (eds.). Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 71-75 5 p.. Research output: Chapter in Book/Report/Conference proceeding › Chapter ...
Riddle, Oscar (1937) Physiological responses to prolactin. In: Cold Spring Harbor Symposia on Quantitative Biology V: Internal Secretions, Cold Spring Harbor, N.Y.. ...
Call for Papers, Posters, and Demonstrations Session on Genome-wide Analysis and Comparative Genomics at the Pacific Symposium on Biocomputing 2003 The sequencing of over 800 complete genomes presents unprecedented opportunities for biological discovery as well as new technical challenges for the computational sciences.This session calls for papers on novel computational algorithms and biological applications in genome-wide analysis and comparative genomics. The session will bring together researchers from the biological, computational and mathematical fields with the goal of sharing new research ideas and achieving a better understanding of the current issues and challenges. The analysis of complete genomes and the comparison of multiple complete genomes are leading to deep biological insights in a variety of areas.However, many of the computational problems in analyzing, aligning and comparing large genomes, and the mathematical questions arising from the interpretation of the analyses and ...
Burge, C. B., Tuschl, T. and Sharp, P.A. Splicing of precursors to mRNAs by the spliceosomes. In RNA World II, R. Gesteland, T. Cech, and J. Atkins, eds., Cold Spring Harbor Laboratory Press, NY, pp. 525-560 (1999) Dredge BK, Polydorides AD, Darnell RB. The splice of life: alternative splicing and neurological disease. Nat Rev Neurosci. 2001 Jan;2(1):43-50. Hastings ML, Krainer AR. Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol. 2001 Jun;13(3):302-9. Maniatis T, Reed R. An extensive network of coupling among gene expression machines. Nature. 2002 Apr 4;416(6880):499-506. Nilsen, T.W. RNA/RNA interactions in nuclear pre-mRNA splicing. In: RNA Structure and Function. R. Simons and M. Grunberg-Manago eds., Cold Spring Harbor Laboratory Press, NY, pp. 279-307 (1998). Staley JP, Guthrie C. Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell. 1998 Feb 6;92(3):315-26. Tollervey D, Caceres JF. RNA processing marches on. Cell. 2000 Nov 22;103(5):703-9. ...
Explore the billions of dollars special interest groups are spending on lobbying in Washington, D.C., -- and on what -- at OpenSecrets.org.
Dr. Esther M. Zimmer Lederberg worked with A. Hollaender at the NIH, moving to Yale after getting an M.A. at Stanford University (acknowledging the guidance of G. W. Beadle and E. L. Tatum). During summers, she worked on radiation-induced reverse mutation in at Cold Spring Harbor with A. Hollaender and M. Demerec. At the Osborn Botanical Laboratory at Yale, she did further research on radiation-induced reverse mutation in Neurospora with N. Giles. Her thesis advisor for her Ph.D. was the chairman of the Genetics Department, R. A. Brink. (See "The Emergence of Bacterial Genetics", by T. Brock, Cold Spring Harbor Laboratory Press, 1990, p. 88). ...
Campbell, M. P., Aoki-Kinoshita, K. F., Lisacek, F., York, W. S. & Packer, N. H., 2017, Essentials of glycobiology. Varki, A., Cummings, R. D., Esko, J. D., Stanley, P., Hart, G. W., Aebi, M., Darvill, A. G., Kinoshita, T., Packer, N. H., Prestegard, J. H., Schnaar, R. L. & Seeberger, P. H. (eds.). 3rd ed. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, p. 667-679 13 p.. Research output: Chapter in Book/Report/Conference proceeding › Textbook contribution ...
Cold Spring Harbor, N.Y. - As most good students realize, repeated studying produces good memory. Those who study a lot realize, further, that what they learn tends to be preserved longer in memory if they space out learning sessions between rest intervals. Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have now discovered how this so-called "spacing effect" is controlled in the brain at the level of individual molecules.. Led by Professor Yi Zhong, Ph.D., the CSHL team has found that a protein called SHP-2 phosphatase controls the spacing effect by determining how long resting intervals between learning sessions need to last so that long-lasting memories can form. The study, carried out in a fruit fly model, will appear online in the journal Cell on October 2.. "Although there are many theories that explain the spacing effect at the psychological level and hundreds of studies that back them up, there has not been any understanding of this phenomenon at the neurobiological level," says ...
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Love, W. E., Klock, P. A., Lattman, E. E., Padlan, E. A., Ward, K. B., & Hendrickson, W. A. (1972). The structures of lamprey and bloodworm hemoglobins in relation to their evolution and function. In Cold Spring Harbor symposia on quantitative biology (Vol. 36, pp. 349-357). Cold Spring Harbor Laboratory Press. ...
Robinson, C. and Guille, M. 1999. Immunohistochemistry of Xenopus embryos. Methods Mol. Biol. 127: 89-97. Sive, H.L., Grainger, R.M., and Harland, R.M. 2000. Early development of Xenopus laevis: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. Becker, B.E and Gard, D.L. 2006. Visualization of the cytoskeleton in Xenopus oocytes and eggs by confocal immunofluorescence microscopy. Methods Mol. Biol. 322: 69-86. ...
In this study we set out to determine the role of PPARα in the small intestine using genomics tools. We find that PPARα is very well expressed in the small intestine in both mouse and human. PPARα expression is highest in villus cells and peaks in the proximal jejunum. Activation of PPARα results in altered expression of a large set of genes involved in a variety of pathways, including intestinal lipid handling, cell cycle, differentiation, apoptosis, and host defense. These data suggest an important role for PPARα in the regulation of gene expression in the small intestine.. Under control (fed) conditions we observed few changes in gene expression between wild-type and PPARα null mice. Only 21 genes were significantly altered, most of which are involved in lipid metabolism. These observations are in accordance with numerous studies showing that the effect of PPARα deletion becomes mainly noticeable under conditions of metabolic stress, and does not a priori imply that the physiological ...
Jie Xiao, Johan Elf, Gene-Wei Li, Ji Yu and X. Sunney Xie, Imaging Gene Expression in Living Cells at the Single-Molecule Level in Single Molecule Techniques A Laboratory Manual Edited by Paul R. Selvin and Taekjip Ha, Chapter 7, p. 150, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 2008 ...
Environmental factors in human growth and development. Banbury Report 11. Edited by V. R. Hunt, M. K. Smith, and D. Worth. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory. 1982. xx + 570 pp., figures, tables, references, indices. $62.50 (cloth ...
Genomics is a relatively new field of research, which began in earnest late in the twentieth century, although the basis of DNA was discovered more than a century earlier. The recent progressions made in genomics research have opened up exciting possibilities for genomics applications in other fields, some of which may offer health and medical benefits.
by Elio | The American Society for Microbiology has designated the Cold Spring Harbor Laboratories on New Yorks Long Island as a Milestone in Microbiology site. This is the ASMs way of recognizing locations where important microbiological history was made. For previous sites so honored click here. Cold Spring Harbor has in fact…
Venter Shares Award with James D. Watson, Marilyn & James Simons and Sherry Lansing at Gala New York City Event ROCKVILLE, Md., Nov. 12 /PRNewswire-USNewswire/
Advanced Techniques in Molecular Neuroscience, Cold Spring Harbor Laboratory 2015 Course, Cold Spring Harbor, NY, United States, June 30 - July 16, 2015
Advances in high throughput genomic technologies are laying the foundations for the goal of precision medicine to be realized (Christensen et al. 2015; Aronson and Rehm 2015). Decreasing costs and the capacity to generate larger volumes of human genomics data at faster rates are enabling population level genomics studies to be conducted (Goldfeder et al. 2017; Prokop et al. 2018). However, most of the current population level genomics studies and data generated to date, have a significant population representational bias with the majority of genome sequences being derived from European and North American ancestry, these are regions that have been early adopters of genomic technologies (Popejoy and Fullerton 2016; Prokop et al. 2018). African researchers, in general, have been late adopters of high-throughput technologies for use in population genomics due to more limited resources and funding. To address this critical gap in scientific knowledge about African genomics and population variation, ...
... Personalized Medicine Tumor Board Question: given all we know about a patient, what is the "optimal" treatment? The Cancer Genome Atlas Project (TCGA) SNP Structural variations DNA methylation Gene expression microRNA expression Paired samples/unpaired samples Data Processing Challenges Contamination Subclones Biological questions • Changes in genes between cancer and normals • Disease heterogeneity, subtypes • Joint modeling, mechanisms Integrative approach Meta-analytical approach PARADIGM: PAthway Recognition Algorithm using Data Integration on Genomic Models Xpxn = Wpx(k-1) Z(k-1)xn + epxn cov(e) = diag(ψ1, ψ2,…, ψp) Non-negative matrix factorization XMxN = WMxK x HKxN All matrix entries are nonnegative Minimize X1: an M x N1 matrix X2: an M x N2 matrix X3: an M x N3 matrix X1 = W x H1 X2 = W x H2 X3 = W x H3 TCGA and GWAS, and ENCODE Cancer Treatment Examples http://discover.nci.nih.gov/cellminer/ Gene expression data: HG-U133A chip, mapped to ...
Peking Univeristy, Apr. 11, 2014: One of the most important challenges in the research of life sciences is to attribute physiological functions precisely to responsible genes. Despite the rapid development of toolkits to manipulate individual genes, large-scale screening methods based on the complete loss of gene expression are still missing. A research team led by Prof. Wei Wensheng of the College of Life Sciences, in collaboration with Prof. Huang Yanyi of Biodynamic Optical Imaging Centre (BIOPIC), developed a groundbreaking technique that achieves high-throughput functional genomics in eukaryotes.. Arrayed and pooled screens using RNAi libraries targeting either human or mouse genomes have already been developed and widely used for systematic genetic studies in mammalian cells. However, its limitations are increasingly apparent. In particular, RNAi-based down-regulation of any particular gene expression is not always sufficient to cause phenotypical changes of interest. Taking advantage of ...
The term "genome" originated in 1930; it was used to denote the totality of genes on all chromosomes in the nucleus of a cell. Incredibly, DNA was not identified as the genetic material of all living organisms until 1944. The genetic code was elucidated in 1961 and with these fundamental insights in hand, it was possible to contemplate the concept that biological organisms had a blueprint consisting of finite numbers of genes. The sequence of these genes encoded all of the information required to specify the reproduction, development, and adult function of an individual organism. The massive interest and commitment of resources in both the public and private sectors flows from the generally-held perception that genomics will be the single most fruitful approach to the acquisition of new information in basic and applied biology in the next several decades ...
Background: It is anticipated that cancer risk prediction tools, including those with genomic risk information, will increasingly be used to communicate personalised cancer risk to the public. Receiving information on personal genomic risk of cancer might encourage conversations about cancer prevention and early detection with family, friends and health professionals, but few studies have examined this.. Aims: To explore participant communication about personal genomic risk of melanoma to family, friends and health professionals, using a mixed-methods approach, and to examine results according to participants genomic risk category (low, average, high).. Methods: We conducted a study examining the impact of giving information on personalised genomic risk of melanoma to the public. Participants (n=101) received a personalised booklet presenting their melanoma genomic risk based on variants in 21 genes, together with telephone-based genetic counselling and generic educational materials. They ...
|p||i|BMC Medical Genomics|/i| is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.|/p||p||i|BMC Medical Genomics|/i| is part of the |i|BMC|/i| series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We do not make editorial decisions on the basis of the interest of a study or its likely impact. Studies must be scientifically valid; for research articles this includes a scientifically sound research question, the use of suitable methods and analysis, and following community-agreed standards relevant to the research field.|/p||p|Specific criteria for other article types can be found in the submission guidelines.|/p||p||i|BMC series - open, inclusive and trusted.|/i||/p|
Computational Genomics. Lecture 1, Tuesday April 1, 2003. Biology in One Slide. High Throughput Biology. DNA Sequencing. …ACGTGACTGAGGACCGTG CGACTGAGACTGACTGGGT CTAGCTAGACTACGTTTTA TATATATATACGTCGTCGT ACTGATGACTAGATTACAG ACTGATTTAGATACCTGAC TGATTTTAAAAAAATATT…. High Throughput...
The agricultural applications of genomics have been underway for some time in the form of genetically-modified crops. Energy applications of genomics are in development using synthetic biology to generate fossil fuel replacements and are estimated to be ready for commercial launch in 2011. The public health application of genomics is especially promising, using genomics to further understand and eradicate disease. Genetic information is already starting to be medically actionable and is likely to become increasingly useful over time. Its two main current uses are in pharmacogenomics, personalized therapeutics, categorizing drug responders and non-responders for tailored treatment, and in routing higher-risk individuals to earlier screenings for chronic diseases such as prostate cancer and breast cancer. It is estimated that each individual is in the upper 5% risk tier for at least one chronic disease and that $100,000 per person per condition could be saved as a result of earlier detection. By ...
Genomics can revolutionize breeding and research, but for this to become a reality, scientists must be allowed to focus on the research problem, and not on the technology. The CEG is enabling this possible by making the highly sophisticated equipment required for this research available to scientists.. By offering genotyping and sequencing service on cost-to-cost basis, coupled with support in data analysis and interpretation, CEG is committed to enhance adoption of genomics in breeding programmes to increase yield.. CEGs Vision is to make it possible for agricultural breeding & research programs to fully utilize modern genomics tools in developing countries.. ...
Driven by new technologies for data acquisition, integrative genomic studies comprising large numbers of samples are poised to revolutionize the way we approach...
The NGI together with Nederlands Wetenschappelijk Onderzoek (NWO) announces the publication of GenomiX, a magazine that introduces genomics by the youth in a modern way. [4] The aim is to increase elementary scientific knowledge of the youth. 700.000 issues have been folded into mainstream youth magazines. This way NGI hopes to reach 75 percent of the youngsters between 12 and 14 years old. Although NGI makes the magazine sound objective by using terms like information and scientific knowledge, the NGI is clearly a genomics promoting organisation as their mission statement reveals. In addition to the GenomiX magazine the NGI launched the website www.genomics.nl aimed at the same group of young people. Without disclosing the evident pro-genomics attitude of the makers, the website provides a seemingly neutral, flashy and spectacular view on genomics. ...
The GOMED programme aims to provide a platform for clinicians to tap into the rich and varied expertise of CSIR-IGIB in disease genomics to solve clinical problems. The Institute brings to table its pioneering expertise in genomics in the country, demonstrated over almost a decade through the Indian Genome variation project, the sequencing of first Indian personal genome and ongoing clinical genomics efforts in rare and common diseases with a large number of public and private healthcare institutions in the country.
The GOMED programme aims to provide a platform for clinicians to tap into the rich and varied expertise of CSIR-IGIB in disease genomics to solve clinical problems. The Institute brings to table its pioneering expertise in genomics in the country, demonstrated over almost a decade through the Indian Genome variation project, the sequencing of first Indian personal genome and ongoing clinical genomics efforts in rare and common diseases with a large number of public and private healthcare institutions in the country.