OpenLink Virtuoso version 07.20.3215 as of Jan 18 2016, on Linux (x86_64-unknown-linux-gnu), Single-Server Edition (15 GB total memory ...
This is the median value of the N=83 RNASeq FPKM expression values for this gene in this life-stage (Embryo) of this species of all samples in the SRA that are wildtype controls that do not appear to have undergone any experimental conditions or treatment that would affect gene expression ...
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Directory. Start here to access encyclopedic information about the worm genome and its genes, proteins, and other encoded features… Find out more. ...
The palette of natural perfumers is expanding, and natural isolates are one way to add new notes, nuances and special effects to your perfumes as well as challe
With the Caenorhabditis briggsae genome now in hand, C. elegans biologists have a powerful new research tool to refine their knowledge of gene function in C. elegans and to study the path of genome evolution.
The wormbase gene report ( http://www.wormbase.org/db/gene/allele?name=e996;class=Allele ) suggests there are several other alleles for this gene with Jonathon Hodgkin as the contact see http://www.wormbase.org/db/misc/etree?name=CB;class=Laboratory Anthony m.larsen wrote: , I am working on sup-1 and was wondering if anyone has other alleles ,than e995. , In particular I would be interested in the x-ray induced e995xri. The , reference allele e995 is the only allele available from the CGC, so if anyone , would be able to provide me with additional sup-1 alleles I would be very , greatful. , , Thank you , , Morten K. Larsen , University of Southern Denmark , DK , m.larsen at bmb.sdu.dk , , --- ...
Leandro X. et, al, Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma mansoni Pinpoints Secreted Proteins for Vaccine Development, https://doi.org/10.1021/acs.jproteome.9b00531 Nov. 15, 2019.. Schistosomes are blood-dwelling helminth parasites that cause schistosomiasis, a debilitating disease resulting in inflammation and, in extreme cases, multiple organ damage. Major challenges to control the transmission persist, and the discovery of protective antigens remains of critical importance for vaccine development. Rhesus macaques can self-cure following schistosome infection, generating antibodies that target proteins from the tegument, gut, and esophagus, the last of which is the least investigated. We developed a dissection technique that permitted increased sensitivity in a comparative proteomics profiling of schistosome esophagus and gut. Proteome analysis of the male schistosome esophagus identified 13 proteins encoded by microexon genes ...
...AMES Iowa -- There are numerous plant-parasitic nematodes in the worl...Now Iowa State University researchers have contributed to the release...Sequencing the genome is a critical step toward comprehensively unders... This is considered to be one of if not the most important plant-para...,ISU,researchers,help,map,first,plant-parasitic,nematode,genome,sequence,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
The blood flukes Schistosoma mansoni and Schistosoma japonicum inflict immense suffering as agents of human schistosomiasis. Previous investigations have found the nervous systems of these worms contain abundant immunoreactivity ...
WormBase ParaSite is an open access resource providing genome sequences, genome browsers, semi-automatic annotation and comparative genomics analysis for nematode and platyhelminth parasites (helminths).
WormBase ParaSite is an open access resource providing genome sequences, genome browsers, semi-automatic annotation and comparative genomics analysis for nematode and platyhelminth parasites (helminths).
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2_point_data Evidence #Evidence Genotype UNIQUE Text Results UNIQUE Text Experiment Mapper ?Author Laboratory ?Laboratory Date UNIQUE DateType Temperature UNIQUE Text Point_1 UNIQUE Gene_1 UNIQUE ?Gene XREF 2_point UNIQUE ?Variation XREF In_2_point Locus_1 UNIQUE ?Locus XREF 2_point UNIQUE ?Variation XREF In_2_point Allele_1 UNIQUE ?Variation XREF 2_point Rearrangement_1 UNIQUE ?Rearrangement XREF 2_point Transgene_1 UNIQUE ?Transgene XREF 2_point Point_2 UNIQUE Gene_2 UNIQUE ?Gene XREF 2_point UNIQUE ?Variation XREF In_2_point Locus_2 UNIQUE ?Locus XREF 2_point UNIQUE ?Variation XREF In_2_point Allele_2 UNIQUE ?Variation XREF 2_point Rearrangement_2 UNIQUE ?Rearrangement XREF 2_point Transgene_2 UNIQUE ?Transgene XREF 2_point // Point_1 and Point_2 are tag2 for the mapped loci // for now to use this on a map both must be on it with Position type Map info. Calculation UNIQUE Full UNIQUE Int UNIQUE Int UNIQUE Int UNIQUE Int // WT X Y XY One_recombinant UNIQUE Int UNIQUE Int // WT X Selected ...
STORAGE CONDITIONS: It is recommended to store away from direct light in full sealed containers in a dry and well ventilated area ...
1. Baldwin, J.G., Nadler, S.A., and Wall, D.H. 1997. Nematodes: Pervading the Earth and Linking all Life. Pp. 176-191. In: Raven, P.H. (ed.). National Academy Press, Washington, D.C. 625 pp.. 2. Bargmann, C. I. 1998. Neurobiology of the Caenorhabditis elegans genome. Science 282:2028-2033.. 3. Bargmann, C. I. And Mori, I. 1997. Chemotaxis and Thermotaxis. Pp. 717-737. In: Riddle, D.L., Blumenthal, T., Meyer, B.J. and Priess, J.R. (eds). C. elegans II. Cold Spring Harbor Laboratory Press, Plainview, NY 1222 pp.. 4. Bird, D.M. and Opperman, C. H. 1998. Caenorhabditis elegans. J. Nematol. 30:299-308.. 5. Bird, D.M., Opperman, C.H., Jones S.J.M., and Baillie, D.L. 1999. The Caenorhabditis elegans gemome: a guide in the post genomics age. Annu. Rev. Phytopathol. 37:247-265.. 6. Blaxter, M. 1998. Caenorhabditis elegans is a nematode. Science 282:2041-2046.. 7. Blaxter, M. and Bird, D. 1997. Parasitic nematodes. Pp. 851-878. In: Riddle, D.L., Blumenthal, T., Meyer, B.J. and Priess, J.R. (eds). C. ...
Ong, T.-H., Romanova, E.V., Roberts-Galbraith, R., Yang, N., Zimmerman, T.A., Collins, J.J., Lee, J.E., Kelleher, N.L., Newmark, P.A., and J.V. Sweedler. 2016. Mass spectrometry imaging and identification of peptides associated with cephalic ganglia regeneration in Schmidtea mediterranea. J. Biol. Chem. 291: 8109-8120 ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Fetal Alcohol Spectrum Disorder (FASD) is a prevalent developmental disease that is caused by excess in utero exposure to ethanol. The importance of timing and dosage of ethanol has been elucidated by previous investigations conducted with humans, rodents, and other model organisms, but challenges associated with determining functional deficiencies have necessitated the introduction of a novel animal model for investigating the dynamics of FASD. In this thesis, we propose that the freshwater flatworm planarian species, Schmidtea mediterranea, has the capability to fulfill this need. Planaria have the ability to completely regenerate fragments into intact, functional animals, and in these studies, we exploited this property to characterize nervous system development in the presence of ethanol. Functional testing of head-regenerating planaria included planarian locomotor velocity testing to assess locomotor capabilities and light avoidance testing to assess development of innate negative phototaxic
Numerous smedwi-1+ cluster attributes indicate they result from clonal growth. smedwi-1+ clusters were preceded by isolated smedwi-1+ cells present 3 to 4 days after irradiation and typically displayed 3 to 10 cells after one week (Fig. 1, E and F). Based on the low proportion of animals with smedwi-1+ cells in close proximity 3 days post-irradiation with 1750 rad (fig. S2), it is improbable that clusters arose from multiple adjacent smedwi-1+ cells (P = 0.0138, two-tailed Fishers exact test). Cluster size increased dramatically over time, suggesting exponential growth and ultimately yielding hundreds of smedwi-1+ cells 14 to 18 days post-irradiation (Fig. 1, E and F). Consistent with clusters originating from pre-existing smedwi-1+ cells that survived irradiation, a cluster-location scatter plot resembled the normal smedwi-1+ expression pattern (Fig. 1D), and cluster frequency decreased with increasing irradiation doses (see below). Bromodeoxyuridine (BrdU) delivery labels smedwi-1-expressing ...
ID A0A183JXR4_9TREM Unreviewed; 990 AA. AC A0A183JXR4; DT 07-SEP-2016, integrated into UniProtKB/TrEMBL. DT 07-SEP-2016, sequence version 1. DT 27-SEP-2017, entry version 9. DE SubName: Full=Uncharacterized protein {ECO:0000313,WBParaSite:SCUD_0000751201-mRNA-1}; OS Schistosoma curassoni. OC Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida; OC Schistosomatoidea; Schistosomatidae; Schistosoma. OX NCBI_TaxID=6186 {ECO:0000313,Proteomes:UP000050789, ECO:0000313,WBParaSite:SCUD_0000751201-mRNA-1}; RN [1] {ECO:0000313,Proteomes:UP000050789, ECO:0000313,WBParaSite:SCUD_0000751201-mRNA-1} RP NUCLEOTIDE SEQUENCE. RG Helminth Genomes Consortium; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313,WBParaSite:SCUD_0000751201-mRNA-1} RP IDENTIFICATION. RG WormBaseParasite; RL Submitted (JUN-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the potassium channel family. CC {ECO:0000256,SAAS:SAAS00692852}. CC ...
The TALEN approach works in C. briggsae Lo et al. 2013,Wood et al. 2011, Wei et al. 2013. The CRISPR/Cas9 method is now implemented in C. briggsae and other species. Using the same plasmids as in C. elegans is possible, at least in C. briggsae: see Culp et al. in biorxiv. Using Cas9 protein and synthetic guide RNA may overcome problems of germ line silencing and of inadequate promoters or 3UTR in other species. See Witte et al. 2015 in Pristionchus pacificus. This method has been successfully used in several Caenorhabditis species (Marie Delattre). ...
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Scientists at the Max Planck Institute for Developmental Biology, together with American colleagues, have decoded the genome of the Pristionchus pacificus nematode, thereby gaining insight into the evolution of parasitism. ...
2007 Rätsch et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: February 2, 2006; Accepted: December 20, 2006; Published: February 23, 2007. Funding. This work was supported in part by the IST Programme of the European Community, under the PASCAL Network of Excellence, IST-2002-506778. Partial funding from the German Research Foundation (MU 987/2-1) is appreciated. Competing interests. GR, SS, KRM, and BS are authors of a patent application (PCT WO05116246) related to the technical innovations of the proposed method. Editor: Uwe Ohler, Duke University, United States of America. We gratefully acknowledge inspiring discussions with Anja Neuber, Alexander Zien, Andrei Lupas, Detlef Weigel, Alan Zahler, Koji Tsuda, Christina Leslie, Eleazar Eskin, and Ivo Grosse. Alexander Zien additionally helped ...
New release of WormBase WS223, Wormpep223 and Wormrna223 Mon Jan 24 12:12:08 GMT 2011 WS223 was built by Paul Davis -===================================================================================- The WS223 build directory includes: genomes DIR - contains a sub dir for each WormBase species with sequence, gff, and agp data genomes/b_malayi: - genome_feature_tables/ sequences/ genomes/c_brenneri: - genome_feature_tables/ sequences/ genomes/c_briggsae: - genome_feature_tables/ sequences/ genomes/c_elegans: - annotation/ genome_feature_tables/ sequences/ genomes/c_japonica: - genome_feature_tables/ sequences/ genomes/c_remanei: - genome_feature_tables/ sequences/ genomes/h_bacteriophora: - genome_feature_tables/ sequences/ genomes/h_contortus: - genome_feature_tables/ sequences/ genomes/m_hapla: - genome_feature_tables/ sequences/ genomes/m_incognita: - sequences/ genomes/p_pacificus: - genome_feature_tables/ sequences/ *annotation/ - contains additional annotations i) confirmed_genes.WS223.gz ...
Above: A nematode seen under a microscope. UF/IFAS photo by Tyler Jones.. A parasite is an organism that lives on or inside of another organism, weakening its host but usually not killing it. This feature distinguishes it from a parasitoid, which typically does kill its host.. Words related to parasite include parasitic (adjective), parasitism (noun) and parasitize (verb). Obligate parasitism occurs when an organism can only survive by its parasitic relationships with another organism.. Plant-parasitic nematodes are one example of a parasitic bug. These nematodes are very small and may only be visible with a microscope. Like other nematodes, plant-parasitic nematodes live in the soil, where they feed on plants.. Many of these parasitic nematodes attack plants from the outside with a spear-like body part called a stylet. Because of this behavior we call them ectoparasites, parasites that live on the outside of their host.. Other nematodes live inside a plant, making them endoparasites. Root-knot ...
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003 ...
Responsibility for (1) the accuracy of statements of fact, (2) the authenticity of scientific findings or observations, (3) expressions of scientific or other opinion and (4) any other material published in the journal rests solely with the author(s) of the article in which such statements, etc., appear. The Journal, its owners, publishers, editors, reviewers and staff take no responsibility for these matters.. Submission of an eLetter also indicates that the author agrees to abide by the Journals policies. Authors must declare any competing interests upon submission.. The Company of Biologists applies the Creative Commons Attribution (CC-BY) License to all articles and associated material published in BiO.. We reserve the right to edit or remove eLetters once published.. Unprofessional submissions will not be considered or responded to.. ...
Because planarians can regenerate a complete body from a tissue fragment they present a powerful system in which to study cell, tissue and organ regeneration, and to look for conserved developmental mechanisms. Peter Reddien and colleagues now describe a regulatory programme for the regeneration of the planarian Schmidtea mediterranea excretory system, the protonephridia (see p. 4387). The S. mediterranea protonephridia consists of tubules, which are dispersed throughout the animals body, two types of tubule-associated cells, and ciliated terminal cells, which drive filtration from the extracellular space into the tubule lumen. The researchers use RNAi screening assays and microarray analyses to show that Six1/2-2, POU2/3, hunchback, Eya, Sal1 and Osr, which encode transcriptional regulators, are involved in protonephridia regeneration. Notably, apart from hunchback, all these genes are also required for vertebrate kidney development. Moreover, the researchers show that planarian and vertebrate ...
Hallmann, Johannes (2003) Ein bedeutender Schädling im ökologischen Landbau: Meloidogyne hapla Chitwood. Biologische Bundesanstalt für Land- und Forstwirtschaft (BBA), D-Münster , Institut für Nematologie und Wirbeltierkunde. This list was generated on Tue Dec 12 00:52:37 2017 CET. ...
WormBase is an online biological database about the biology and genome of the nematode model organism Caenorhabditis elegans and contains information about other related nematodes. WormBase is used by the C. elegans research community both as an information resource and as a place to publish and distribute their results. The database is regularly updated with new versions being released every two months. WormBase is one of the organizations participating in the Generic Model Organism Database (GMOD) project. WormBase comprises the following main data sets: The annotated genomes of Caenorhabditis elegans, Caenorhabditis briggsae, Caenorhabditis remanei, Caenorhabditis brenneri, Caenorhabditis angaria, Pristionchus pacificus, Haemonchus contortus, Meloidogyne hapla, Meloidogyne incognita, Brugia malayi and Onchocerca volvulus; Hand-curated annotations describing the function of ~20,500 C. elegans protein-coding genes and ~16,000 C. elegans non-coding genes; Gene families; Orthologies; Genomic ...
Septins are guanosine-5-triphosphate-binding proteins involved in wide-ranging cellular processes including cytokinesis, vesicle trafficking, membrane remodelling and scaffolds, and with diverse binding partners. Precise roles for these structural proteins in most processes often remain elusive. Identification of small molecules that inhibit septins could aid in elucidating the functions of septins and has become increasingly important, including the description of roles for septins in pathogenic phenomena such as tumorigenesis. The plant growth regulator forchlorfenuron, a synthetic cytokinin known to inhibit septin dynamics, likely represents an informative probe for septin function. This report deals with septins of the human blood fluke Schistosoma mansoni and their interactions with forchlorfenuron. Recombinant forms of three schistosome septins, SmSEPT5, SmSEPT7.2 and SmSEPT10, interacted with forchlorfenuron, leading to rapid polymerization of filaments. Culturing developmental stages ...
Author SummaryEukaryotic genes contain introns, which are intervening sequences that are excised from a gene transcript with the concomitant ligation of flanking segments called exons. The process of removing introns is called splicing. It involves biochemical mechanisms that to date are too complex to be modeled comprehensively and accurately. However, abundant sequencing results can serve as a blueprint database exemplifying what this process accomplishes. Using this database, we employ discriminative machine learning techniques to predict the mature mRNA given the unspliced pre-mRNA. Our method utilizes support vector machines and recent advances in label sequence learning, originally developed for natural language processing. The system, called mSplicer, was trained and evaluated on the genome of the nematode C. elegans, a well-studied model organism. We were able to show that mSplicer correctly predicts the splice form in most cases. Surprisingly, our predictions on currently unconfirmed genes
Using our Illumina RNAseq approach, we identified hundreds of differentially regulated genes during different stages of head regeneration, and clustered them into groups according to their dynamic expression profiles (Figure 6c).. Among the genes that were strongly upregulated during the first few hours of regeneration were genes encoding putative homologues of mammalian inflammatory response genes. Gene_3164, for instance, encodes a putative tumor necrosis factor receptor (TNFR)-associated protein (TRAF). TRAFs interact with numerous members of the TNFR family and have a variety of tissue-specific functions. As TRAFs have been implicated in promoting the immune response after infections and wounding [42, 43], it is possible that similar proteins are also involved in the regulation of immune responses after decapitation in planarians. Reported RNAi phenotypes of putative TRAF-like genes in the planarian species D. japonica are pleiotropic [44]. Thus, the functions of putative planarian TRAFs, as ...
A study of peptide hormones in the brain of a seemingly primitive flatworm reveals the surprising complexity of its nervous system and opens up a new approach for combating a major parasitic disease, researchers report.. The study appears in the open-access journal PLoS Biology.. The planarian flatworm, Schmidtea mediterranea, is perhaps best known for its prodigious powers of regeneration. Cut it in half (lengthwise or crosswise) and each fragment will regrow its missing parts, including its brain. The planarian is of interest to those studying reproduction because it exists in sexual and asexual varieties. Asexual planaria reproduce by splitting into two pieces and then regenerating. Sexual planaria are hermaphroditic. Some planaria can even switch between the sexual and asexual forms.. The free-living planarian is also of interest because it is related to several parasitic flatworms. For example, flatworms of the genus Schistosoma parasitize more than 200 million people worldwide. Schistosome ...
Working with starved L1 larvae of C. elegans and C. briggsae we noticed that these two species behave quite differently in starvation. First, C. elegans adults stop laying eggs after exhausting bacterial food, which eventually leads to internal hatching and bagging. C. briggsae do not show this behavior. This difference has been observed before (McCulloch and Gems, 2003). Second, at high enough density of worms, arrested C. elegans L1s aggregate on agar plates after several days of starvation (Fig. 1a). C. briggsae L1s do not form aggregates (Fig. 1b). Aggregation may serve several purposes ranging from decrease of surface to volume ratio and use of diffusible "public goods" to sharing information about quality of the environment. Third, survival of starved C. elegans L1s strongly depends on their density - the higher the worm density, the longer they survive (Fig. 1c) (Artyukhin et al., 2013). This holds true for starvation on plates as well as in suspension. Survival of C. briggsae L1s is ...
This remarkable book contains everything you need to know about Serrapeptase, including; the history, in-depth studies and detailed health plans for over 240 health conditions. ...
Benzimidazole anti-microtubule drugs, such as benomyl, induce paralysis and slow the growth of the nematode Caenorhabditis elegans. We have identified 28 mutations in C. elegans that confer resistance to benzimidazoles. All resistant mutations map to a single locus, ben-1. Virtually all these mutations are genetically dominant. Molecular cloning and DNA sequence analysis established that ben-1 encodes a beta-tubulin. Some resistant mutants are completely deleted for the ben-1 gene. Since the deletion strains appear to be fully resistant to the drugs, the ben-1 product appears to be the only benzimidazole-sensitive beta-tubulin in C. elegans. Furthermore, since animals lacking ben-1 are viable and coordinated, the ben-1 beta-tubulin appears to be nonessential for growth and movement. The ben-1 function is likely to be redundant in the nematode genome. ...
Figure 4B shows the polarized SFS of clade C on a double-logarithmic scale such that power laws show as straight lines. At frequencies ,20%, the observed SFS is compatible with a 1/k decay as expected in neutrally evolving populations of constant size (Wakeley 2008). At higher frequencies, however, the SFS decreases much more rapidly, before increasing again for alleles close to fixation. Similar U-shaped SFS have been observed in plants (Cao et al. 2011). At intermediate derived allele frequencies between 20% and 40%, the slope of the SFS is compatible with 1/k2, indicated as a dashed line in Figure 4B. The 1/k2 behavior and the nonmonotonicity are expected if the dominant force changing allele frequencies is selection at linked (genetic draft) loci regardless of whether this variation is positively or negatively selected (Braverman et al. 1995; Neher and Shraiman 2011; Neher and Hallatschek 2013).. Compared to the almost 100-fold variation in the SFS between singletons and alleles at ...
Flatworm: Flatworm, any of the phylum Platyhelminthes, a group of soft-bodied, usually much flattened invertebrates. A number of flatworm species are free-living, but about 80 percent of all flatworms are parasitic-i.e., living on or in another organism and securing nourishment from it. They are bilaterally
Comparing strains within the same microbial species has proven effective in the identification of genes and genomic regions responsible for virulence, as well as in the diagnosis and treatment of infe
Micropublications are submitted through the pre-designed forms found on Micropublication:biology. Follow the instructions on the form. If the submission forms cannot accommodate your data, please contact us at [email protected] More information about what is accepted in the forms can be found here. ...
For the upcoming WS249 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.. Winter AD, Weir W, Hunt M, Berriman M, Gilleard JS, Devaney E, Britton C.Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics. 2012 Jan 4;13:4.. miRNA genes are referenced from the WBPaper00040579 entry.. Winter AD, Gillan V, Maitland K, Emes RD, Roberts B, McCormack G, Weir W, Protasio AV, Holroyd N, Berriman M, Britton C, Devaney E. A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics. 2015 Apr 22;16(1):331.. referenced genes: let-7, Bm6643, Bm5914, Bma-tag-97, Bma-mir-5364. Cinkornpumin JK, Wisidagama DR, Rapoport V, Go JL, Dieterich C, Wang X, Sommer RJ, Hong RL. A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus. Elife. 2014 Oct ...
Pathogenic host-microbe interactions can result from continuous evolution of a hosts ability to resist infection and a pathogens ability to survive and replicate. Pseudomonas aeruginosa is a versatile and opportunistic pathogen, ubiquitous in soil, and capable of damaging plants, vertebrates, and invertebrates. Previous studies in nematodes suggest that the pathogenic effects of P. aeruginosa can result from multiple distinct pathways: a toxin-based effect that kills within a few hours and a generalized virulence that kills over the course of multiple days. Using experimental evolution in the highly polymorphic nematode Caenorhabditis remanei, I show that nematode resistance to the two modes of pathogenesis in P. aeruginosa evolves through genetically independent pathways. These results demonstrate that multiple virulence factors in a pathogen can result in multiple responses in the host, and the genetic lines established here create resources for further exploration of the genetic basis for ...
Platyhelminthes tutorial all along with the key concepts of Characteristics of Platyhelminthes, Triploblastic Condition of Platyhelminthes, Acoelomate Condition, Classification of Flatworms, Structure Adults, Life Cycle of Tape Worm and Life cycle of Taenia
C. elegans utilizes an extensive chemical "language" that allows individuals to communicate and regulates basic behaviors such as feeding, mating, and population density control [Edison, 2009]. Hundreds of nematode ascarosides are now known [Ludwig and Schroeder, 2013], and some receptors have been identified [e.g. McGrath et al., 2011]. We still know very little about how the components work together, how the chemical signals are regulated, and receptors and other gene products that transduce signals into behavior. We are working to understand the environmental factors that control ascaroside expression and to identify additional ascarosides in other nematode species. This information will not only add to the extensive scientific knowledge of C. elegans but may provide important new clues for the biological control of other nematode parasites of plants or animals. We are also taking a metabolomics approach to this problem and are developing a new large-scale project to map the C. elegans ...
You have something in common with a flatworm: more than 100 mucosal proteins. In a recent paper in Molecular and Cellular Proteomics, researchers showed that the freshwater planarian Schmidtea mediterranea has proteins in its mucous coating that are strikingly similar to ones in human mucus and other secretions, such as tear fluid.. The work grew out of a lab rotation project by a graduate student, Donald Bocchinfuso at the University of Toronto, who set up a collaboration between the laboratories of Michael Moran (an expert in mass spectrometry) and Bret Pearson (an expert in planarians) at the Hospital For Sick Children in Toronto, Canada. Bocchinfuso was interested in analyzing the mucous coating on the worms by MS.. "The idea to compare worms before and after removing their mucous coating started out as a simple technical step," says Moran. "However, it grew to become a central part of the study, in part because we are at a childrens hospital and, therefore, have an awareness of the huge ...
Allie Mac Kay was live at Rosas Under Dog Boot Camp to tell us about Rosas program that is designed for anyone who wants to get in shape and accomplish that with their dog as their partner. Rosa also talks about how this bootcamp includes obedience training for dogs.