B-cell Immunoglobulin Gene Rearrangement
Describes how B-cell immunoglobulin gene rearrangement tests are used, when they are ordered, and what the results of B-cell immunoglobulin gene rearrangement tests might mean
HKU Scholars Hub: A study of clonality of lymphoma of SJL mice using immunoglobulin gene rearrangements and murine leukaemia...
Conference Paper: A study of clonality of lymphoma of SJL mice using immunoglobulin gene rearrangements and murine leukaemia virus ...
Genes, Immunoglobulin | Harvard Catalyst Profiles | Harvard Catalyst
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity ...
Browse by Eprint ID - CaltechAUTHORS
Schlissel, Mark S. and Corcoran, Lynn M. and Baltimore, David (1991) Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. Journal of Experimental Medicine, 173 (3). pp. 711-720. ISSN 0022-1007. https://resolver.caltech.edu/CaltechAUTHORS:SCHLjem91 ...
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Atlas: PAX5 (paired box gene 5)
Involved in a multitude of developmental processes, PAX5 expression is not only continuously required for B cell lineage commitment during early B cell development but also for B lineage maintenance, involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene ...
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Final Analysis from RESONATE: Six-Year Follow-Up in Patients with Previously Treated CLL/SLL Receiving Ibrutinib
Long-term follow-up of patients receiving ibrutinib showed sustained efficacy, low rates of discontinuation, and acceptable tolerability with no new safety signals over time. This analysis provides additional evidence supporting ibrutinib as standard of care in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL).
What Patients With CLL/SLL Should Know About the FDAs Approval of Calquence
Acalabrutinib in Combination With Anti-CD20 and Venetoclax in Relapsed/Refractory or Untreated CLL/SLL/PLL - Full Text View -...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
IMGT Repertoire (IG and TR)
IMGT, the international ImMunoGeneTics information system for immunoglobulins
or antibodies, T cell receptors, MH, immunoglobulin superfamily IgSF and MhSF.
Expertly annotated databases and on-line tools (IMGT/V-QUEST, IMGT/JunctionAnalysis) for gene sequences,
genetics and protein 3D structures. Molecular biology, genetics, immunology of antigen receptors, in immunoinformatics,
clinical and veterinary research, genome diversity studies and antibody engineering
IMGT Repertoire (IG and TR)
IMGT, the international ImMunoGeneTics information system for immunoglobulins
or antibodies, T cell receptors, MHC, immunoglobulin superfamily IgSF and MhcSF.
Expertly annotated databases and on-line tools (IMGT/V-QUEST, IMGT/JunctionAnalysis) for gene sequences,
genetics and protein 3D structures. Molecular biology, genetics, immunology of antigen receptors, in immunoinformatics,
clinical and veterinary research, genome diversity studies and antibody engineering
IMGT Repertoire (IG and TR)
IMGT, the international ImMunoGeneTics information system for immunoglobulins
or antibodies, T cell receptors, MHC, immunoglobulin superfamily IgSF and MhcSF.
Expertly annotated databases and on-line tools (IMGT/V-QUEST, IMGT/JunctionAnalysis) for gene sequences,
genetics and protein 3D structures. Molecular biology, genetics, immunology of antigen receptors, in immunoinformatics,
clinical and veterinary research, genome diversity studies and antibody engineering
IMGT Repertoire (IG and TR)
IMGT, the international ImMunoGeneTics information system for immunoglobulins
or antibodies, T cell receptors, MHC, immunoglobulin superfamily IgSF and MhcSF.
Expertly annotated databases and on-line tools (IMGT/V-QUEST, IMGT/JunctionAnalysis) for gene sequences,
genetics and protein 3D structures. Molecular biology, genetics, immunology of antigen receptors, in immunoinformatics,
clinical and veterinary research, genome diversity studies and antibody engineering
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Alvespimycin Hydrochloride in Treating Patients With Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B...
PRIMARY OBJECTIVES:. I. To determine the maximum tolerated dose (MTD) of 17-DMAG in patients with relapsed CLL/SLL and B-PLL.. II. To define the dose limiting toxicity (DLT) of 17-DMAG in patients with relapsed CLL/SLL and B-PLL.. SECONDARY OBJECTIVES:. I. To assess preliminary efficacy of 17-DMAG in patients with relapsed CLL/SLL and B-PLL.. II. To determine the pharmacokinetics of 17-DMAG in patients with relapsed CLL/SLL and B-PLL.. III. To determine the feasibility of measuring pharmacodynamic markers of 17-DMAG including the Hsp90 client proteins Akt and IKK-alpha/IKK-beta.. IV. To determine if FoxD3 and downstream genes such as EPHA7 and ID4 are re-expressed in CLL cells following treatment with 17-DMAG.. V. To correlate pharmacokinetic features of 17-DMAG with response, toxicity and pharmacodynamic endpoints.. VI. To correlate risk parameters such as ZAP-70 with response to 17-DMAG.. OUTLINE: This is a dose-escalation study.. Patients receive alvespimycin hydrochloride intravenously (IV) ...
PLC?s in B cell biology and autoimmunity - Demin Wang
Early B cell development and late B cell maturation are regulated by signals emanating from the pre-B cell receptor (BCR) and BCR, respectively. During maturati...
Duvelisib for Relapsed or Refractory CLL/SLL | Drug Topics
T-Cell Gene Rearrangement | Poplar Health Care
The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.. ...
Astrocytoma Archives - trkmutations.com
Browsing NGS databases for TRK gene rearrangements can lead to more profound questions regarding their origin. In our sister website we had only one example of an TRK2 gene rearrangement, QKI-TRK2. The COSMIC database was searched revealing one more TRK2 ...
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31 - October - 2011
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12 - November - 2012
アトミック・エイジは核兵器と原発に関連する問題について批判的に考察し、行動につなげていくためのプロジェクトです。当サイトでは核兵器と原発に関する日本語と英語などのニュースを毎日更新しています。更新情報は RSS 、ツイッター及びフェースブックから受け取ることができます。日本語の更新情報のみを受け取りたい方は、この RSS にご登録ください。. ...
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