TY - JOUR. T1 - A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. AU - McCormick, Mark A.. AU - Delaney, Joe R.. AU - Tsuchiya, Mitsuhiro. AU - Tsuchiyama, Scott. AU - Shemorry, Anna. AU - Sim, Sylvia. AU - Chou, Annie Chia Zong. AU - Ahmed, Umema. AU - Carr, Daniel. AU - Murakami, Christopher J.. AU - Schleit, Jennifer. AU - Sutphin, George L.. AU - Wasko, Brian M.. AU - Bennett, Christopher F.. AU - Wang, Adrienne M.. AU - Olsen, Brady. AU - Beyer, Richard P.. AU - Bammler, Theodor K.. AU - Prunkard, Donna. AU - Johnson, Simon C.. AU - Pennypacker, Juniper K.. AU - An, Elroy. AU - Anies, Arieanna. AU - Castanza, Anthony S.. AU - Choi, Eunice. AU - Dang, Nick. AU - Enerio, Shiena. AU - Fletcher, Marissa. AU - Fox, Lindsay. AU - Goswami, Sarani. AU - Higgins, Sean A.. AU - Holmberg, Molly A.. AU - Hu, Di. AU - Hui, Jessica. AU - Jelic, Monika. AU - Jeong, Ki Soo. AU - Johnston, Elijah. AU - Kerr, Emily O.. AU - Kim, ...
Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line more or less appropriate for particular studies. The purpose of this work encompasses both a review of transgenes that lead to the expression of Cre recombinase in the lens and a comparative analysis of currently available transgenic lines with a particular emphasis on the Le-Cre and P0-3.9GFPCre lines that can mediate DNA deletion in the lens placode. Although both of these transgenes are driven by elements of the Pax6 P0 promoter, the Le-Cre transgene consistently leads to ocular abnormalities in homozygous state and can lead to ocular defects on some genetic backgrounds when hemizygous. Although both P0-3.9GFPCre and Le-Cre hemizygous transgenic mice undergo normal eye development on an FVB/N genetic background, Le-Cre homozygotes uniquely exhibit microphthalmia. Examination of the expression patterns of these two transgenes revealed similar
KIP2 deletion affects Bik1 localization at cMT +tips. (A) Bik1 localization in WT (GFP-TUB1) and kip2Δ mutant. In the mutant, Bik1 accumulation is reduced or a
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Heterozygous mutations of the NRXN1 gene, which encodes the presynaptic cell-adhesion molecule neurexin-1, were repeatedly associated with autism and schizophrenia. However, diverse clinical presentations of NRXN1 mutations in patients raise the question of whether heterozygous NRXN1 mutations alone …
A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals. The absence of this single gene, called p21, confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander. .... Snyder found that p21, a cell cycle regulator, was consistently inactive in cells from the MRL mouse ear. P21 expression is tightly controlled by the tumor suppressor p53, another regulator of cell division and a known factor in many forms of cancer. The ultimate experiment was to show that a mouse lacking p21 would demonstrate a regenerative response similar to that seen in the MRL mouse. And this indeed was the case. As it turned out, p21 knockout mice had already been created, were readily available, and widely used in many studies. What had not been noted was that these mice could heal their ears. ...
Deleting the ATDC gene blocked tumor formation in a well-known mice model of pancreatic cancer, revealing a potential target for cancer prevention.
Author Summary Transfer RNAs are an important component of the translation machinery. Despite extensive biochemical investigations, a systems-level investigation of tRNAs functional roles in physiology, and genetic interactions among them, is lacking. We created a comprehensive tRNA deletion library in yeast and assessed the essentiality of each tRNA in multiple conditions. The majority of tRNA deletions showed no appreciable fitness defect when such strains were grown on rich medium. More challenging environmental conditions, however, revealed a richer set of specific-tRNA phenotypic defects. Co-deletion of tRNA combinations revealed that tRNAs with essential function can be compensated by members of the same or different anti-codon families. We often saw that identical tRNA gene copies contribute deferentially to fitness, suggesting that the genomic context of each gene can affect functionality. Genome-wide expression changes in response to tRNA deletions revealed two different responses. When a
Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79巻, 5号, pp.790-pp.794, MAY 4 ...
PreciseDeletion is a database of primers for the precise scar free deletion of genes, according to the methods described in Aubrey et al. (2015) A Tool for Multiple Targeted Genome Deletions that Is Precise, Scar-Free, and Suitable for Automation. doi: 10.1371/journal.pone.0142494.. Primer details can be queried using this form. The current primers were uploaded on 16th December 2014. For large volumes of queries we ask that you download the complete dataset, using the download links below.. ...
The target of rapamycin protein (TOR) is a highly conserved ataxia telangiectasia-related protein kinase essential for cell growth. Emerging evidence indicates that TOR signaling is highly complex and is involved in a variety of cellular processes. To understand its general functions, we took a chemical genomics approach to explore the genetic interaction between TOR and other yeast genes on a genomic scale. In this study, the rapamycin sensitivity of individual deletion mutants generated by the Saccharomyces Genome Deletion Project was systematically measured. Our results provide a global view of the rapamycin-sensitive functions of TOR. In contrast to conventional genetic analysis, this approach offers a simple and thorough analysis of genetic interaction on a genomic scale and measures genetic interaction at different possible levels. It can be used to study the functions of other drug targets and to identify novel protein components of a conserved core biological process such as DNA damage ...
Strain sensitivity to different translation-inhibitory drugs. Wild type (WT) or gene deletion mutant strains (yploo9cΔ, yil137cΔ, ypl183w-aΔ, ydr056cCΔ and
In article ,Pine.3.07.9406011347.A11088-b100000 at labsun1.med.uottawa.ca,, g056432 at LABSUN1.MED.UOTTAWA.CA (jeffrey wigle , grad stud) writes: ,, Hello ,, ,, Im using Qiagen purified plasmid DNA to sequence with a T7 sequencing ,, kit. Generally the sequence Ive got has been very clear but occasionally ,, I get no sequence at all from a given deletion timepoint. ,, The amount of DNA used for sequencing was approx. the same for the ,, deletions that worked and the ones that didnt -as measured by a ,, spectrophotometer. I denatured the plasmid with NaOH for 5 minute and ,, then ethanol precipitated before sequencing. The plasmid is ,, bluescript and the kit used for deletion was Erase-a-BASE. I protected ,, with BSTXI and I opened the plasmid up for digestion with HindIII. The ,, deletions looked fine when run on an agarose gel (only one major band at ,, each timepoint). ive done deletions before and did not have this ,, problem but i was using single stranded sequencing(phagemid was ,, ...
To update or delete an entity, you will need to be capable of recognize it by using the PartitionKey and RowKey values. In this regard, your choice of PartitionKey and RowKey for modifying entities should observe related requirements towards your option to guidance position queries since you wish to identify entities as proficiently as you possibly can. You dont need to use an inefficient partition or table scan to locate an entity if you want to find the PartitionKey and RowKey values you need to update or delete it. The subsequent designs within the section Table Structure Designs address optimizing the general performance or your insert, update, and delete operations: Significant volume delete sample - Enable the deletion of the higher volume of entities by storing all the entities for simultaneous deletion in their own individual independent table; you delete the entities by deleting the table ...
My sons is 4 yrs 9 months. His deletion is big (3 to 43). Before knowing the deletion I was encouraged about exon skipping. I asked Dr Wilton from Australia…
Vascularization is an essential process involved in embryonic development and vascular remodeling. Numerous stimuli (i.e. shear stress, cytokines, growth factor...
Wikia is not accessible if youve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected ...
Identifies conditions (media and gene deletions) so that a reaction of interest is essential for a measurable function (e.g. growth ...
Institut za molekularnu genetiku i genetičko inženjerstvo je prestižna ustanova koja se bavi fundamentalnim istraživanjima u oblasti molekularne biologije, i njihovom primenom u zdravstvu, poljoprivredi i industriji.
Institut za molekularnu genetiku i genetičko inženjerstvo je prestižna ustanova koja se bavi fundamentalnim istraživanjima u oblasti molekularne biologije, i njihovom primenom u zdravstvu, poljoprivredi i industriji.
if (!doesSchemaExist(schemaType, schemaName)) { throw new NotFoundException(schemaType + / + schemaName); } switch (schemaType) { case VIRTUAL: virSchemaDAO.delete(schemaName); break; case DERIVED: derSchemaDAO.delete(schemaName); break; case PLAIN: default: plainSchemaDAO.delete(schemaName); } }. As you can read the second class has a control on schema existence, the first one hasnt. We have to add the same check on the ConfigurationLogic class.. Relevant mail thread: http://markmail.org/message/3ufidttokvw2km5k. ...
talk contribs deleted page User:Adrianrequarth (Vandalism: content was: เหตุผลที่ดื่ม Collagen คนที่มีอายุ 25 ขึ้นไปจะมีปริมาณคอลล... (and the only contributor was [[Special:Contributions/Adrianrequarth,Adria...) ...
We previously developed the DBRF-MEGN (d ifference-b ased r egulation f inding-m inimum e quivalent g ene n etwork) method, which deduces the most parsimonious signed directed graphs (SDGs) consistent with expression profiles of single-gene deletion mutants. However, until the present study, we have not presented the details of the methods algorithm or a proof of the algorithm. We describe in detail the algorithm of the DBRF-MEGN method and prove that the algorithm deduces all of the exact solutions of the most parsimonious SDGs consistent with expression profiles of gene deletion mutants. The DBRF-MEGN method provides all of the exact solutions of the most parsimonious SDGs consistent with expression profiles of gene deletion mutants.
Rugsėjo 22 d. Biotechnologijos instituto Mikroskysčių technologijų sektoriuje besisvečiuojantys Prof. Hirotada Mori (Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan) ir Prof. Barry L. Wanner, Microbiology and Immunobiology Harvard Medical School,USA) skaitys pranešimus. Seminarų pradžia - 13 val., tarp seminarų planuojama trumpa, apie 15 min. trukmės, pertrauka. Seminarai vyks R-101 auditorijoje.. Pranešimų trumpos anotacijos: Prof. Hirotada Mori. Title: Monitoring population dynamics of Escherichia coli K-12 in stationary phase - An application of the new resource of E. coli - Abstact: We monitored population changes in mixed-cultures of our recently developed single-gene deletion mutant library of Escherichia coli K-12 carrying molecular bar-codes. Our bar-coded library is similar to the single-gene deletion Keio mutant library, except target genes were replaced with a chloramphenicol instead of a kanamycin resistance cassette and deletions ...
© 2015 Elsevier B.V. We have synthesized a series of luminescent iridium(III) complexes and investigated their ability to act as luminescent split G-quadruplex probes. After screening, the iridium(III) complex 1 [Ir(2-phenylquinoline)2(3,4,7,8-tetramethyl-1,10-phenanthroline)]PF6 was validated as a highly-selective G-quadruplex probe and was utilized to construct a label-free intermolecular G-quadruplex-based assay for the selective and sensitive detection of LMP1 gene deletion. This mix-and-detect assay is simple and selective, and could detect down to 10nM of the target gene in aqueous solution with a linear range from 10 to 500nM. We also investigated the performance of our split G-quadruplex-based sensing platform for LMP1 gene deletion in the presence of cellular debris, demonstrating the robustness of this sensing system in biological samples. Comparative assays were also performed using either organic dyes or labeled oligonucleotides as signal-transducing agents.
Multiple Deletions in Logistic Regression Models - Conditional deletions;logistic regression models;masking effects;multiple deletions;outliers;swamping effects;
An image encoding apparatus generate encoded data having a fixed length L which is less than or equal to m n bits and an integral multiple of 32 by m n pixel block, while resolution information and color information are excellently maintained. For this purpose, a block generation unit inputs image data by m n pixels. A 2-color extraction unit extracts representative colors C0 and C1 from the input block image data. An identification information detection unit generates m n items of identification information each identifying each pixel in the block as a pixel approximate to one of the colors C0 and C1. An identification information deletion unit deletes the items of identification information in corresponding positions based on a deletion pattern stored in a deletion pattern memory. A packing unit packs the colors C0, C1 and the identification information after deletion, and outputs the data as encoded data.
TY - JOUR. T1 - Characterization of two unusual RS1 gene deletions segregating in Danish retinoschisis families. AU - Huopaniemi, L AU - Tyynismaa, H AU - Rantala, A AU - Rosenberg, T AU - Alitalo, T PY - 2000. Y1 - 2000. KW - retinoschisis, X-linked. KW - genomic deletion. KW - RS1. KW - retinochisis. KW - PPEF-1. KW - serine-threonine phosphatase. KW - STK9. KW - serine-threonine kinase. KW - LINKED JUVENILE RETINOSCHISIS. KW - RETINAL-DEGENERATION. KW - FOUNDER MUTATIONS. KW - KINASE GENE. KW - XLRS1 GENE. KW - EXPRESSION. KW - PROTEIN. KW - PHOSPHATASE. KW - PROMOTER. KW - CLONING. KW - 118 Biological sciences. KW - genetiikka. M3 - Article. VL - 16. SP - 307. EP - 314. JO - Human Mutation. JF - Human Mutation. SN - 1059-7794. ER - ...
PURPOSE: Submicroscopic deletions of chromosome band 2p25.3 are associated with intellectual disability and/or central obesity. Although MYT1L is believed to be a critical gene responsible for intellectual disability, so far no unequivocal data have confirmed this hypothesis. METHODS: In this study we evaluated a cohort of 22 patients (15 sporadic patients and two families) with a 2p25.3 aberration to further refine the clinical phenotype and to delineate the role of MYT1L in intellectual disability and obesity. In addition, myt1l spatiotemporal expression in zebrafish embryos was analyzed by quantitative polymerase chain reaction and whole-mount in situ hybridization. RESULTS: Complete MYT1L deletion, intragenic deletion, or duplication was observed in all sporadic patients, in addition to two patients with a de novo point mutation in MYT1L. The familial cases comprise a 6-Mb deletion in a father and his three children and a 5 MYT1L overlapping duplication in a father and his two children. ...
Our results show that antitumor efficacy was greatly improved when E1B19K-deleted mutants were combined with subtherapeutic concentrations of the cytotoxic drug gemcitabine. In addition, the sensitization was specific for cancer cells and did not occur in normal cultured cells. Although we and others previously proposed incorporation of the E1B19K deletion in already potent replication-selective oncolytic mutants, this gene deletion had not been studied on its own (16-18, 20, 22, 25). Mutants with additional deletions in death-related genes such as ADP, E1B55K, or E3B were reported to have higher potency and improved spread in cancer cells. During viral infection the E1B55K and E3B genes protect against p53- and death receptor-induced apoptosis, respectively. The Ad5ΔE1B19K mutant used in this study was engineered to lack only the E1B19K antiapoptotic gene and was compared with mutants with E3B deletions with and without E1B19K. Our goal was to establish the role of a single E1B19K deletion in ...
Our molecular genetics lab offers single-gene deletion and duplication analysis through comparative genomic hybridization (CGH). Learn the indications and more.
TY - JOUR. T1 - ΔF508 GENE DELETION IN CYSTIC FIBROSIS IN SOUTHERN EUROPE. AU - Estivill, X.. AU - Casals, T.. AU - Morral, N.. AU - Chillon, M.. AU - Bosch, A.. AU - Nunes, V.. AU - Gasparini, P.. AU - Seia, A.. AU - Pignatti, P. F.. AU - Novelli, G.. AU - Dallapiccola, B.. AU - Fernandez, E.. AU - Benitez, J.. AU - Williamson, R.. PY - 1989/12/9. Y1 - 1989/12/9. UR - http://www.scopus.com/inward/record.url?scp=0024965903&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024965903&partnerID=8YFLogxK. U2 - 10.1016/S0140-6736(89)92024-2. DO - 10.1016/S0140-6736(89)92024-2. M3 - Article. C2 - 2574355. AN - SCOPUS:0024965903. VL - 334. SP - 1404. JO - The Lancet. JF - The Lancet. SN - 0140-6736. IS - 8676. ER - ...
Dear National Jewish Hospital, Ive been trying to get to the source of a primary immune deficiency that affects both my son and I. Researchers at CHOP discovered that we share a C2 gene deletion, so a few days ago, my son David Noah, had blood sent to your lab for C2 and C3 function…
A novel DFNB1 deletion allele supports the existence of a distant **cis**-regulatory region that controls **GJB2** and **GJB6** expression ...
To understand regulatory systems, it would be useful to uniformly determine how different components contribute to the expression of all other genes. We therefore monitored mRNA expression genome-wide, for individual deletions of one-quarter of yeast genes, focusing on (putative) regulators. The resulting genetic perturbation signatures reflect many different properties. These include the architecture of protein complexes and pathways, identification of expression changes compatible with viability, and the varying responsiveness to genetic perturbation. The data are assembled into a genetic perturbation network that shows different connectivities for different classes of regulators. Four feed-forward loop (FFL) types are overrepresented, including incoherent type 2 FFLs that likely represent feedback. Systematic transcription factor classification shows a surprisingly high abundance of gene-specific repressors, suggesting that yeast chromatin is not as generally restrictive to transcription as ...
It should be noted that for proteins containing both an ABM-1 and ABM-2 motif, the contribution of each motif to binding to ALG-2 is not fully understood yet. For instance, deletion of ABM-1 in CHERP (Q8IWX8) only slightly weakens binding to ALG-2, while deletion of ABM-2 has a more profound effect. Deletion of both motifs however, nearly abrogates binding (Sasaki-Osugi,2013). Similarly, PLSCR3 lacking its ABM-1 can bind both the longer and shorter isoform of ALG-2, while deletion of ABM-2 still allows binding to only the longer isoform. Binding to either isoform is lost upon deletion of both motifs (Shibata,2008). For Sec31A, loss of ABM-1 has no obvious effect, while loss of ABM-2 results in a weak interaction, although similar to the ALIX ABM-1 used as a positive control in the experiment (Shibata,2010). In addition, although Annexin A7 and A11 do not have a characterized ABM-2, they contain a sequence that resembles the ABM-2 sequences in CHERP, and they were predicted to have a low- and ...
What causes DiGeorge syndrome? As mentioned, 90 percent of patients with the features of this syndrome are missing a small part of their chromosome 22 at the q11 region. This region encompasses about 30 individual genes and results in developmental defects in specific structures throughout the body. It is not known why this region of chromosome 22 is prone to become deleted, but this is one of the most frequent chromosome defects in newborns. Deletion 22q11.2 is estimated to occur in one in 3,000 to 4,000 live births. Most of the 22q11.2 deletion cases are new occurrences or sporadic (occurs by chance). However, in about 10 percent of families, the deletion is inherited and other family members are affected or at risk for passing this deletion to their children. The gene is autosomal dominant, therefore, any person who has this deletion has a 50 percent chance of passing the deletion to a child. For this reason, whenever a deletion is diagnosed, both parents are offered the opportunity to have ...
Feature :. N-terminal deletion of prnp (on Prnp background) introduction of constuct pPrPN-term: (sequence encoding AA 68-83 was deleted). ...
We have seen a nice and a quitesimple solution for measuring the similarity between two sequences. It relied on the so-called hammingdistance that is counting the number of differencesbetween two sequences. But the real situation is a bitmore complex as well see now, it needs an adequatesolution and algorithm. Why is it a bit more complex? Lets have a look at thispair of two sequences. If we apply the hamming distance,compute the hamming between these two sequences,we find ten differences. OK. But you must remember thatmutation may be substitution, deletion and insertion. So if wetake into account the deletion and insertion, the situation isvery different in the case of these two sequences. Lets see why. We can compare now that it isthe same set of sequences but here and here we made the hypothesisof insertion or deletion. Insertion or deletion depend on thesequence you take into account and one substitution. Instead ofhaving ten differences, the same sequences show only twoinsertions/deletions and
With respect to the TAP‐tagged proteins used in the different deletions (Figure 3), as we expected, all the proteins from the same module as the TAP‐tagged protein were highly recovered and had high probabilities. For instance, in Spt7-TAP-gcn5Δ;sgf29Δ, the highest probabilities were observed for Tra1, Ada1 and all the SPTs proteins with Spt8 exhibiting the highest probability (Figure 3A). Interestingly, for Spt8-TAP-sgf29Δ, Spt7 has the highest probability (after Spt8), suggesting a strong association between these two proteins (Figure 3A). To begin, we inspected the HAT/Core module and investigated the effect of the GCN5, SGF29 and ADA2 deletions on this module as well as on the entire complex. In the specific purifications that contain these deletions, ada2Δ had a greater effect on the HAT/Core module when compared with gcn5Δ and sgf29Δ (Figures 2A and 3B). Independent of the TAP‐tagged bait used, all and only the components of the HAT module were lost in ada2Δ (Figure 2A). In ...
3q deletion information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
View Notes - BIS101 HW6 F08 Engebrecht from BIS 101 at UC Davis. Deletions x Point mutations 1 2 3 4 5 1 2 3 4 5 1 - - - - + a + - - + + 2 - - + + b + + - + - 3 - - - c - + - - + 4 - + d - - - + + 5
View Notes - relationship to other organisms from CHEMISTRY CHM1025 at Broward College. York, the smallest visible deletion (about 4Mb) would represent about an 8 km gap and that on this scale, the
Thank you Carol for explaining this to me. I knew it was better to have both deletions but I didnt know why. I knew your chances of a longer life span had to do with deletions. My husband has one deletion and he has been ok for 2 years now. He does have some issues with memory and retaining information if it is a lot at one time butt I am thankful that is all we are dealing with. Although I dont post often, I still follow many of the threads on this site and pray for everyone here. His doctors told us he removed all the tumor in 2010 but there could be infiltrating cells. I try not to worry and enjoy life but I seem to worry more as more time passes since the diagnosis was 3 1/2 to 5 years, although I am praying that he will be here to see our daughter become an adult and have children of her own. I am glad to hear yourson has the deletions and is doing so well. Its good to hear from people that are doing well. It gives me hope. Their tumor was located in the same area and it sounds like they ...
A method and system for reliably performing extra-long operations in a reliable state-full system (such as a file system). The file system includes a separate portion of the file system reserved for files having extra-long operations in progress, including file deletion and file truncation. This separate portion of the file system is called the zombie file space; it includes a separate name space from the regular (
We initiate the first systematic study of the NP-hard Cluster Vertex Deletion (CVD) problem (unweighted and weighted) in terms of fixed-parameter algorithmics. In the unweighted case, one searches for
DiscoSnp. DiscoSnp is designed for discovering all kinds of SNPs (not only isolated ones), as well as insertions and deletions, from raw set(s) of reads. The number of input read sets is not constrained, it can be one, two, or more. No reference genome is needed. ...
Get the deletion tolerance site-process specific parameter for a collection of Site objects aggregated by a Sequence object. This method does some error checking and the calls getParameterAtSites(this=this,process=process,id=deletion.tolerance,index=index). See getParameterAtSites.Sequence for more details.
Chromosomal deletions in DNA often involve just one of two gene copies inherited from either parent. But scientists havent known how a deletion in one gene from one parent, called a hemizygous deletion, can contribute ...
Polyploidy, increased sets of chromosomes, occurs during development, cellular stress, disease and evolution. Despite its prevalence, little is known about the physiological alterations that accompany polyploidy. We previously described ploidy-specific lethality, where a gene deletion that is not …
The 12/10/2011 version of Keep Teeth White While Smoking has been deleted for inc. Caidoz, Davecrosby voted for the deletion. No one voted against the deletion. It had 25 views at time of deletion.. ...
To erase a single atom or bond, click on it. Deletion of the terminal bond deletes the terminal atom by default. Pressing the Alt button while deleting the bond, the terminal atom is not deleted. To change the default behavior, go to Edit , Preferences , Bonds tab and choose the desired Terminal Bond Deletion Method.. ...
If you reach a requirements to prevent some table for deletions or/and updates you may wonder how to reach that. The simple answer is to use INSTEAD OF triggers. INSTEAD OF triggers override the standard action of triggering statement: INSERT, UPDATE or DELETE. On that way, INSTEAD OF trigger can ignore parts of the batch, not process part of the batch or taking an alternative action. The major difference to the AFTER triggers is that INSTEAD OF triggers can be defined on a views as well as on a tables ...
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