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TY - JOUR. T1 - Plasma fibronectin and serum complement C3 levels in chronic active hepatitis following virus B versus virus C infection.. AU - Abdel Rahman, M. M.. AU - el Nasr, M. S.. AU - Mahmoud, S. A.. AU - Soliman, A.. AU - Salama, M. M.. PY - 1993/8/1. Y1 - 1993/8/1. N2 - Plasma fibronectin and serum complement C3 levels were estimated in 30 patients with chronic active hepatitis (CAH) post virus B and another 30 patients with CAH post virus C as well as 20 normal healthy subjects. Fibronectin level was significantly increased in CAH when compared to normal controls. Moreover, fibronectin level was significantly increased in CAH following virus C when compared to CAH following virus B hepatitis. Concerning complement C3 there was no significant changes in the different groups studied. We may conclude that CAH following virus C may lead to vigorous inflammatory damage than CAH following virus B infection.. AB - Plasma fibronectin and serum complement C3 levels were ...

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Standard optimization techniques fall short of being able to solve simulated systems or, more generally, black-box systems since these techniques rely on first and second derivatives of algebraic objectives and constraints to identify search directions and test for optimality. In these cases, derivative-free optimization (DFO) solvers can be used. However, when the design of a process involves discrete variables and complex nonlinear objectives and constraints, the resulting problem topology is often too complex for DFO methods to solve reliably.. To facilitate use of standard algebraic optimization methods for the solution of simulated or experimental systems, we developed ALAMO to generate a set of algebraic surrogate models to describe these systems. The surrogate models can be combined with design constraints and algebraic objectives to formulate an algebraic optimization problem. This optimization model can then be used to design all discrete and continuous process alternatives, technology ...

ANA MARIA KESE(1), VIOLETA COMaNESCU(2), MARIA COMaNESCU(2), CRISTIANA SIMIONESCU(3), DENISA ENESCU-BIERU(1) (1) Sport and Physical Education Faculty, University of Craiova; (2) Laboratory of Pathology, Emergency County Hospital Craiova; (3) Department of Pathology, University of Medicine and Pharmacy of Craiova ABSTRACT This study included 116 cases of liver serologically confirmed biopsies, which were clinico-pathologicaly assesed. We

Hi, Are you HIV positive? This is an HIV information Web site. Ill reprint some information about parvovirus B-19 below. If this does not answer your question and you are HIV positive, please...

Revisiting the cysteine‐rich proteins encoded in the 3‐proximal open reading frame of the positive‐sense single‐stranded RNA of some monopartite lamentous plant viruses: functional dissection of p15 from grapevine virus B. ...

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Large scale implementation of CO2 geologic sequestration requires detailed uncertainty analysis and risk assessment for leakage potential. Probabilistic risk assessment based on Monte Carlo simulation is one option for quantifying the risk. It involves repeated random realizations of a simulator to generate probability distributions of interesting variables such as leakage amount. However, in the context of modeling CO2 plume migration underground after injection, numerical solution of non-linear equation systems for heat and mass balances is too time-intensive for Monte Carlo simulation. To cope with this computational expense, investigators are often forced to make simplifying assumptions and resort to approximate models. To address this challenge, instead of solving a large system of non-linear equations, we first develop a surrogate model for the multi-component multi-phase flow processes involved in the injection of CO2 into deep saline aquifers. In particular, we use TOUGH2 in conjunction ...

Preferred: Serum gel. Acceptable: Red top. Specimen Volume: 0.25 mL. Additional Information: 1. Incidence of influenza virus infections is seasonal in the United States and usually occurs only from November to March.. 2. Indicate influenza virus B.. ...

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##VEEV MARMOSET MODEL## Venezuelan equine encephalitis virus (VEEV) is a potentially re-emerging pathogen that has been responsible for several epizootics and epidemics. VEEV is also of interest due to its high infectivity when aerosolized, and its

Please click here to see the presentation. Abstract: Mismatch repair pathway (MMR) is essential to maintain genome stability. While MutS and MutL are essential for performing the initial and steps of the route, those are missing in many Archaea, most Actinobacteria, and other prokaryotes. However, these organisms exhibit similar spontaneous mutation rates to those bearing the MMR proteins. We have reported NucS, as an endonuclease involved in Mismatch repair (MMR) with no structural homology to known MMR factors. By genetic screenings we found [1] that this protein is required for mutation avoidance and anti-recombination, hallmarks of the canonical MMR in the surrogate model Mycobacterium smegmatis, lacking classical MutS-MutL factors. Furthermore, phenotypic analysis of naturally occurring polymorphic NucS in a M. smegmatis surrogate model, suggests the existence of M. tuberculosis mutator strains. Structural bioinformatics coupled to evolutionary studies of NucS indicate a complex making-up ...

In Kolkata it is a common feature for laboratory staff to come and collect blood samples. The syringe they use may be contaminated with HIV/AIDS virus. How can one |b|make such syringes 100% free from HIV/AIDS virus|/b|?

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Ive decided to start posting abstracts and links to papers that I find interesting. Todays topic: GB virus C.. GBV-C is a non-pathogenic virus that infects humans. This 2014 paper details the impact of co-infection with HIV-1. Ultimately they conclude that GBV-C co-infection may be beneficial to HIV-1 patients. However, the benefits of GBV-C are not apparent when patients are treated with anti-retroviral therapy.. Impact of GB virus C viraemia on clinical outcome in HIV-1-infected patients: a 20-year follow-up study.. D Ernst, M Greer, R Akmatova, S Pischke, H Wedemeyer, H Heiken, HL Tillmann, RE Schmidt and M Stoll. HIV Medicine v. 15 p. 245-250. ...

ISHS XII International Symposium on Virus Diseases of Ornamental Plants CHARACTERIZATION OF A SEVERE STRAIN OF CHRYSANTHEMUM VIRUS B (CVB) ISOLATED FROM CHRYSANTHEMUM IN INDONESIA

GB virus type C (GBV-C) is a common human flavivirus that has been associated with prolonged survival in HIV-positive individuals in several, though not all, epidemiological studies. There are five distinct GBV-C genotypes that are geographically localized, and it has been speculated that GBV-C genotypic differences may explain variable outcomes observed in different clinical studies. Expression of an 85 aa fragment of the GBV-C NS5A phosphoprotein (genotype 2) in a CD4+ T cell line (Jurkat) resulted in inhibition of HIV replication, mediated in part by decreased surface expression of the HIV coreceptor CXCR4 and upregulation of SDF-1. We expressed the NS5A protein from genotypes 1, 2, 3 and 5 in Jurkat cells, and demonstrated that all genotypes inhibited HIV replication. Further deletion mapping demonstrated that expression of a 30 aa fragment resulted in decreased CXCR4 surface expression, upregulation of SDF-1 and inhibition of HIV replication.

Results show non-pathogenic E1 GB virus C protein as an attractive source of peptides for development of novel anti-HIV therapies- Global Medical Discovery

ECHAGUE, G et al. Complementary tests for the problem of B and C virus infection diagnosis in blood donors. Mem. Inst. Investig. Cienc. Salud [online]. 2009, vol.7, n.1, pp.5-12. ISSN 1812-9528.. The aim of this study was to determine if liver transaminases had value as complementary tests to orientate the diagnosis of hepatitis B and C in blood donors with positive antibody to these viral infections by the EIA method, considering that confirmatory tests such as the recombinant immunoassay (RIBA) or nucleic acid test by molecular techniques such as PCR (HCV RNA) for hepatitis C and viral DNA (PCR) for hepatitis B are not performed in our country due to their high costs. We are looking for joining efforts in public health from the blood banks due to the importance of reaching a diagnosis of seropositive donors who have been detected in the screening to prevent the spread of hepatitises. Serologic tests for hepatitis C, antibodies against the core antigen of hepatitis B and determinations of the ...

Morphological investigations on the lung in a common marmoset model for human asthma. The exact pathophysiological mechanisms of allergic asthma, especially with regard to chronicity, are still unclear. As in other areas, animal models have proven to be useful in generating and verifying hypotheses on pathophysiological aspects of human disease. In cooperation with the Fraunhofer Institute for Toxicology and Experimental Medicine in Hanover, a study was set up with the aim to experimentally induce asthma in common marmosets. In this context, morphometric studies were performed on the right caudal lung lobe of common marmosets to assess the effects of different asthma protocols (short-term and long-term) and of therapeutic intervention with a glucocorticoid (budesonide). Due to the fact that non-ciliated epithelial cells and respiratory mast cell populations play an important role in allergic asthma, the focus of this study was on CCSP and mucin-secreting cells as well as on tryptase and ...

If you have a question about this talk, please contact [email protected].. UNQW02 - Surrogate models for UQ in complex systems. Routine diagnostic checking of stationary Gaussian processes fitted to the output of complex computer codes often reveals nonstationary behaviour. There have been a number of approaches, both traditional and more recent, to modelling or accounting for this nonstationarity via the fitted process. These have included the fitting of complex mean functions to attempt to leave a stationary residual process (an idea that is often very difficult to get right in practice), using regression trees or other techniques to partition the input space into regions where different stationary processes are fitted (leading to arbitrary discontinuities in the modelling of the overall process), and other approaches which can be considered to live in one of these camps. In this work we allow the fitted process to be continuous by modelling the covariance kernel as a finite mixture of ...

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Figure: Secondary structures of the Coxsackie Virus B RNA and the encoded proteins. Taken from van Ooij, M.J., Vogt, D.A., Paul, A., Castro, C., Kuijpers, J., van Kuppeveld, F.J., Cameron, C.E., Wimmer, E., Andino, R. and Melchers, W.J. 2006, with perm ...

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Our current understanding of sepsis and multiple organ dysfunction needs to be revised, as the uniformly negative results of new therapies for these disorders suggest.Previous theories for the pathogenesis of these conditions are incomplete; reasons for this include the following. First, the surrogate models that have been used to study these disorders are not analogous to the clinical situation. Second, patients who have less severe manifestations of these diseases are often overlooked. And third, patients preexisting conditions have not been taken into account. Considerable new evidence indicates that, in addition to a massive proinflammatory reaction, a compensatory anti-inflammatory response contributes to the onset of these disorders. At a local site of injury or infection and during the initial appearance of pro- and anti-inflammatory mediators in the circulation, the beneficial effects of these mediators outweigh their harmful effects. Only when the balance between these two forces is ...

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