GATA-1 and FOG-1 zinc fingers. Computer model showing the complex of the zinc finger transcription factors GATA-1 (orange) and FOG-1 (friend of GATA, blue). The two zinc ions shown in grey become visible after removing a few atoms hiding them. - Stock Image C035/5609
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RNA Polymerase II (RNAP II) is recruited to core promoters by the pre-initiation complex (PIC) of general transcription factors. Within the PIC, transcription factor for RNA polymerase IIB (TFIIB) determines the start site of transcription. TFIIB binding has not been localized, genome-wide, in metazoans. Serial analysis of chromatin occupancy (SACO) is an unbiased methodology used to empirically identify transcription factor binding regions. In this report, we use TFIIB and SACO to localize TFIIB binding regions across the rat genome. A sample of the TFIIB SACO library was sequenced and 12,968 TFIIB genomic signature tags (GSTs) were assigned to the rat genome. GSTs are 20-22 base pair fragments that are derived from TFIIB bound chromatin. TFIIB localized to both non-protein coding and protein-coding loci. For 21% of the 1783 protein-coding genes in this sample of the SACO library, TFIIB binding mapped near the characterized 5 promoter that is upstream of the transcription start site (TSS). However,
Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Dec 2011 Kazenwadel J, Secker GA, Liu YJ, Rosenfeld JA, Wildin RS, Cuellar-Rodriguez J, Hsu AP, Dyack S, Fernandez CV, Chong CE, Babic M, Bardy PG, Shimamura A, Zhang M, Walsh T, Holland SM, Hickstein DD, Horwitz MS, Hahn CN, Scott HS, Harvey NL. Source Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia; Abstract Recent work has established that heterozygous germline GATA2 mutations predispose carriers to familial myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML), "MonoMAC" syndrome and DCML deficiency. Here, we describe a previously unreported MDS family carrying a missense mutation in GATA2 (p.Thr354Met), one patient with MDS/AML carrying a frameshift mutation in GATA2 (p.Leu332Thrfs*53), another individual with MDS harboring a GATA2 splice site mutation, and three patients ...
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GATA4 has been ascribed to a number of critical functions in the heart, spanning from the specification and differentiation of cardiac myocytes early in development to the regulation of the cardiac hypertrophic response in the adult. GATA4 mediates these processes through the direct transcriptional control of key cardiac structural and regulatory genes.1 For example, GATA4 has been shown to directly bind the promoters of the ANF, BNP, α-MHC, and β-MHC genes, thereby controlling their expression in the heart.1 Indeed, 3 of these 4 genes showed altered expression in the hearts of Gata4fl/flβMHC-Cre mice, validating the previously proposed proximal regulatory role of GATA4. Cardiac-specific deletion of Gata4 also resulted in the dysregulation of approximately 1.0% of all cardiac-expressed genes, further supporting the overall importance of GATA4 as a homeostatic regulator of gene expression in the heart.. GATA4 is also thought to function as a critical regulator of cardiac hypertrophy, although ...
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009 ...
On the other hand, E‐boxes are absent from an unexpectedly high proportion of TAL1 peaks (14% in Jurkat and 24% in erythroid cells) (Figure 6C). Consistent with this, the de novo motif search did not identify E‐boxes as the top overrepresented motif in erythroid or Jurkat cells (Figure 6A, left and middle panels). Instead, in erythroid cells, a Gata motif ranks first within overrepresented sites, and two variants of this motif are also among the top 7 overrepresented motifs (Figure 6A, middle panel). Furthermore, virtually all TAL1 peaks (96%) contain a Gata motif while only 76% contain an E‐box within a 100‐bp radius of the peak summit (Figure 6C). In erythroid cells, Gata motifs are also on average closer to TAL1 peak summits than E‐boxes, with 80% of TAL1 peaks containing a Gata site within 35 bp of the peak summit versus only 50% containing an E‐box within this distance (Figure 6C). This is consistent with previous studies showing cooccupation of TAL1 and GATA1 at many genomic ...
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Hematopoietic differentiation of the H1-GATA2−/− ES cell line. a CFUs of H1 or H1-GATA2−/− derived CD34+ cells. H1 or H1-GATA2−/− cells were co-cult
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More than 30% of all human cancers contain activating mutations of the small G‐protein RAS. As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS‐driven transformation [1]. Recent studies have indicated that the transcription factor GATA2 is one of these partners in crime, but a mechanistic link between RAS and GATA2 had not been identified [2]. A paper in this issue of EMBO reports closes this gap showing that GATA2 can be activated by p38 in RAS‐transformed cells [3].. See also: KR Katsumara et al (September 2014) ...
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This Is Article About Bokken, Katana Kayu, Tsuba Maru Gata Type 02 with Sageo (tali ito) Bokken dengan model Tsuba bentuk Moru Gata ini dilengkapi Sageo berwarna Hijau dan dilengkapi dengan ornamen-ornamen lainnya sehingga penampilannya mendekati kemiripan dengan pedang katana sungguhan. Disamping indah dipandang mata (cocok buat hiasan atau pajangan) juga sangat cocok untuk latihan seni beladiri samurai. Selain karena penampilannya yang indah, Sageo pada gagang… Selengkapnya ». Rating: 1.0 ...
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cdna:novel chromosome:VEGA66:14:63198922:63245271:-1 gene:OTTMUSG00000032593 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Gata4 description:GATA binding protein 4 ...
Members of the GATA transcription factor family have been used in many transfection studies to investigate their roles in the regulation of gene expression. To correct for variations in transfection efficiency, the Renilla luciferase encoding plasmids pRL-TK and pRL-SV40 are commonly used as normalization controls. We report here that plasmids expressing GATA-4 or GATA-6 transcription factor increased Renilla luciferase gene expression by 2 to 8 fold when co-transfected with pRL-TK or pRL-SV40. This alteration of the control reporter gene activity was shown to cause erroneous normalization of transfection efficiency and thus misinterpretation of results in a transactivation assay. To circumvent the problem, we generated two mutant control plasmids from which putative GATA response elements were deleted. These deletions rendered pRL-SV40 unresponsive to GATA transcription factor stimulation and reduced the response of pRL-TK. A database search also indicates that consensus GATA binding sequences are
To test whether human GATA-1 (hGATA-1) is involved in the transcriptional control of globin gene switching, transgenic mice were produced overexpressing hGATA-1. These were crossed with mice carrying a human beta-globin locus yeast artificial chromosome (beta YAC), and globin gene expression was analyzed in their progeny. Mice carrying both the hGATA-1 and the beta YAC transgenes have normal levels of gamma- and beta-globin mRNA, with no distortion in the rate or in the timing of gamma-to-beta switch, indicating that hGATA-1 is not involved in the developmental control of gamma- and beta-globin genes. In contrast, mice carrying the hGATA-1 and the beta YAC transgenes have 5- to 6-fold lower expression of the human epsilon globin gene compared with beta YAC mice lacking the hGATA-1 transgene. These results provide direct in vivo evidence that hGATA-1 is a specific repressor of human epsilon gene expression. These findings also suggest that binary transgenic mouse systems based on overexpression ...
The role of GATA‐6 in cardiogenesis to date has been unclear. Although gain‐of‐function experiments suggested a role for this GATA factor in heart formation (Jiang and Evans, 1996; Gove et al., 1997; Charron et al., 1999), some loss‐of‐function data suggested that it may not be required at all except in the absence of GATA‐4 and ‐5 (Jiang et al., 1998; Morrisey et al., 1998; Koutsourakis et al., 1999). However, antisense studies demonstrated a requirement for GATA‐6 for specific gene expression during the differentiation of rat neonatal cardiomyocytes in culture (Charron et al., 1999). In this study, we demonstrate for the first time a crucial requirement for GATA‐6 in the maturation and maintenance of cardiomyocytes during embryonic development. We have employed a loss‐of‐function model using antisense MOs to study the function of GATA‐6. The depletion of GATA‐6 in Xenopus and zebrafish embryos causes a dramatic loss of heart tissue. We found that maturation of the ...
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Expression of GATA1 (ERYF1, GATA-1, GF1, NF-E1, NFE1) in liver tissue. Antibody staining with HPA000232, HPA000233 and CAB009195 in immunohistochemistry.
Expression of GATA1 (ERYF1, GATA-1, GF1, NF-E1, NFE1) in colon tissue. Antibody staining with HPA000232, HPA000233 and CAB009195 in immunohistochemistry.
Gata. Am sperat, am daruit, am iubit, am uitat, am lasat, am gresit, am iertat. Am renuntat. Am fost mereu aici. Mi s-a luat. Pa.
An advantage of the zebrafish model is that embryos can survive a cardiomyopathy, which facilitates the analysis of other phenotypes (Heicklen-Klein et al., 2005). In addition to the heart, we find that Gata4 is required for formation of the intestine, liver, pancreas and swim bladder. Gata4/Gata5/Gata6 gene expression has been previously associated with endoderm-derived organs, and mouse knockout models showed specific functions for Gata4 in the foregut (Kuo et al., 1997; Molkentin et al., 1997) and gastric (Jacobsen et al., 2002) epithelium, and for Gata6 in the visceral endoderm (Morrisey et al., 1998) and lung epithelium (Yang et al., 2002). The zebrafish gata5 gene is also essential for gut morphogenesis and liver development, based on the analysis of the faust mutant (Reiter et al., 1999; Reiter et al., 2001), and depletion of Gata6 in Xenopus or zebrafish endoderm appears to disrupt normal intestinal morphogenesis (Peterkin et al., 2003). Therefore, all three of these Gata genes have ...
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GATA1 was first described as a transcription factor that activates the hemoglobin B gene in the red blood cell precursors of chickens.[30] Subsequent studies in mice and isolated human cells found that GATA1 stimulates the expression of genes that promote the maturation of precursor cells (e.g. erythroblasts) to red blood cells while silencing genes that cause these precursors to proliferate and thereby to self-renew.[31][32] GATA1 stimulates this maturation by, for example, inducing the expression of genes in erythroid cells that contribute to the formation of their cytoskeleton and that make enzymes necessary for the biosynthesis of hemoglobins and heme, the oxygen-carrying components of red blood cells. GATA1-inactivating mutations may thereby result in a failure to produce sufficient numbers of and/or fully functional red blood cells.[5] Also based on mouse and isolated human cell studies, GATA1 appears to play a similarly critical role in the maturation of platelets from their precursor ...
Regulation of GATA1 gene expression by HIF1. (A) Real-time PCR analysis of HIF1A and GATA1 mRNA levels in K562 cells transfected with the HIF1α expression plas
The GATA1 gene is associated with X-linked GATA1-related cytopenia (MedGen UID: 335283) and X-linked Diamond-Blackfan anemia (MedGen UID: 266045).
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Leukemia is a form of cancer that develops from blood stem cells. People with leukemia often cant make enough healthy blood cells. This can lead to infections and other serious complications. Dr Mick Bhatia and his team uncovered a surprising cause underlying this problem - changes in nearby fat cells. They also uniquely used a type of drug meant for diabetes that can simultaneously put the brakes on leukemia cells and boost normal blood cell development. This "double duty" treatment could lead to a new therapy to improve overall health outcomes for people with aggressive blood cancers.. Learn more about the impact of our research, supported by your donations.. Photo credit: Mike Lalich Photography. ...
Ver más] GATA transcription factors are expressed in the mesoderm and endoderm during development. GATA1-3, but not GATA4, are critically involved in hematopoiesis. An enhancer (G2) of the mouse Gata4 gene directs its expression throughout the lateral mesoderm and the allantois, beginning at embryonic day 7.5, becoming restricted to the septum transversum by embryonic day 10.5, and disappearing by midgestation. We have studied the developmental fate of the G2-Gata4 cell lineage using a G2-Gata4Cre;R26REYFP mouse line. We found a substantial number of YFP+ hematopoietic cells of lymphoid, myeloid and erythroid lineages in embryos. Fetal CD41+ /cKit+ /CD34+ and Lin- /cKit+ /CD31+ YFP+ hematopoietic progenitors were much more abundant in the placenta than in the aorta-gonad-mesonephros area. They were clonogenic in the MethoCult assay and fully reconstituted hematopoiesis in myeloablated mice. YFP+ cells represented about 20% of the hematopoietic system of adult mice. Adult YFP+ hematopoietic stem ...
November 22, 2017. A research group at Lund University in Sweden has found that when the HLF (hepatic leukemia factor) gene -which is expressed in immature blood cells - does not shut down on time, we are unable to develop a functional long-term immune system. This could be a very early stage of leukemia.. Blood stem cells give rise to all of our blood cells: the red blood cells that transport oxygen, the platelets that enable blood coagulation, and our immune cells that protect us from infections. Immune cells can, in turn, be divided into two groups; one that consists of cells with a very short life expectancy and a natural but rather unspecific ability to counteract infections (myeloid cells), and another that, in contrast, consists of very long-lived cells (lymphocytes) that specialise in combatting specific bacteria and viruses.. "The ability of blood stem cells to form all types of blood cells is a fundamental property that is also utilized in connection with bone marrow transplants. An ...
Introduction: GATA4 gene encodes a member of the GATA family of zinc-finger transcription factors. This protein is thought to regulate genes involved in...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
T GATA2 is present at larger levels within the endothelial cells comprising LVV leaflets (E, arrows) compared with endothelial cells lining the jugular veins and jugular lymph sacs (E, arrowheads). GATA2 can also be present in cardiac valves (F ) and arterial endothelial cells (J ). Boxed region...
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Shilpa Hattangadi has an Electrical Engineering and Computer Science undergraduate degree from MIT. Her postdoctoral work at the Whitehead Institute in Harvey Lodishs lab spurred an interest in applying fundamental molecular biology to intriguing concenpts in red blood cell development. Her initial work on the
A genetic defect found on the GATA2 gene predisposes people to acute myeloid leukemia (AML) and myelodysplasia, researchers have learned.