TY - JOUR. T1 - Effects of GC7101, a novel prokinetic agent on gastric motor function. T2 - Ex vivo study. AU - Jung, Da Hyun. AU - Choi, Eun Ju. AU - Jeon, Han Ho. AU - Lee, Young Ho. AU - Park, Hyojin. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Background/Aims: GC7101, an extract of Lonicera Flos, is a novel developing drug for reflux esophagitis and functional dyspepsia. However, the drugs exact pharmacological mechanism of action remains unclear. This study assessed the effects of GC7101 on gastrointestinal (GI) motor function. Methods: We used male guinea pigs to evaluate the effects of GC7101 on GI motility. The contraction of antral circular muscle in the presence of different doses of GC7101 was measured in a tissue bath. The prokinetic effects of GC7101 were tested using the charcoal transit assay from the pylorus to the most distal point of migration of charcoal mixture. To clarify the mechanism of action of GC7101, atropine, dopamine and the selective 5-hydroxytryptamine 4 receptor ...

Looking for online definition of Gastrointestinal agents in the Medical Dictionary? Gastrointestinal agents explanation free. What is Gastrointestinal agents? Meaning of Gastrointestinal agents medical term. What does Gastrointestinal agents mean?

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The most recent publication of the Clinical Gastroenterology & Hepatology evaluates rates of response to placebo in trials of patients with fistulizing Crohns disease ...

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In Australia so see it each time inflix approval needed. Relys too much on diarrhoea which for me is controlled by pain killers im on. Also only looks at a 2 week window - I could be shocking beforehand but then improve just when the cdai is done. Not sure how they can improve on it and it at least provides some info. Better then nothing. I estimated my cdai as 438, guessing what crp is,at he moment - not sure how this reflects severity but am presently in hospital with abscesses and inflammation of small bowel - and picked up c diff too. So cdai is being skewed by painkillers and anti ds. Just needs to be used as one tool in the gis arsenal of not much else. haha ...

In this article, we break down what exactly prokinetics are, and why they can be a necessary part of treatment for many functional gut disorders.

In this article, we break down what exactly prokinetics are, and why they can be a necessary part of treatment for many functional gut disorders.

BACKGROUND: Infliximab withdrawal in patients with Crohns disease on concomitant antimetabolite therapy is considered to be superior if obtained after a maintenance therapy period compared to induction alone.. METHODS: We retrospectively analyzed the outcome of Crohns disease patients treated with infliximab and an antimetabolite after infliximab was withdrawn using induction alone or induction plus at least 1-year of maintenance therapy. The time to relapse was analyzed using univariate and multivariate analyses. The model was adjusted according to the period of infliximab withdrawal.. RESULTS: A total of 92 patients were included, 54 in the induction alone group. The patient characteristics were identical in the two groups except for the period of infliximab withdrawal. After a median follow-up period of 47.1 (interquartile range=4.4-110.2) months, 66 patients (72%) experienced a relapse. After a year-adjustment, no significant difference was observed between the two groups. Based on ...

This is a multi-centre, randomised, double-blind, placebo-controlled, parallel group study to evaluate the efficacy of two oral doses of GSK1605786A (500 mg once daily, 500 mg twice daily) as compared to placebo in the induction of clinical response over a 12-week treatment period in subjects with moderately-to-severely active Crohns disease. Secondary objectives will include assessment of the safety and evaluation of the efficacy in induction of remission.. The study is planned to randomise approximately 600 subjects (200 subjects/group) with active Crohns disease, diagnosed for at least 4 months with a documented history of disease in the small and/or large intestine, and characterised by a Crohns Disease Activity Index (CDAI) score between 220 to and 450, inclusive. Subjects must have reported an inadequate response or intolerance to Crohns disease treatment with corticosteroids or immunosuppressants. Inclusion of subjects who received prior treatment with a biologic anti-tumour necrosis ...

TY - JOUR. T1 - Mechanism of the acetylcholine-release effect of cisapride on guinea-pig gastrointestinal tract. AU - Chen, H. T.. AU - Pan, S.. PY - 1988/1/1. Y1 - 1988/1/1. UR - http://www.scopus.com/inward/record.url?scp=0023689373&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0023689373&partnerID=8YFLogxK. M3 - Article. C2 - 3179814. AN - SCOPUS:0023689373. VL - 41. SP - 263. EP - 270. JO - Journal of the Chinese Medical Association. JF - Journal of the Chinese Medical Association. SN - 1726-4901. IS - 4. ER - ...

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Cisapride is one of the frequently used prokinetic agent used in a variety of GIT disorders by virtue of its effects of its 5 HT receptor agonism.

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In patients with ASUC, an accelerated infliximab induction strategy reduces the need for early colectomy. An intensified infliximab dosing strategy in response to clinical or laboratory signs of breakthrough inflammation merits consideration in prospective studies.

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Посетительница выставки по имени Би Цин (Bi Qing) уверена, что на фоне процветания и роста китайской экономики она будет потреблять всё больше зарубежных продуктов. Таким образом, выставка принесёт ей дополнительные варианты и сюрпризы.. По словам представителей оргкомитета, кроме традиционных товаров вроде чая, шёлка и фарфора на выставке будут также представлены другие знаменитые продукты - шриланкийские сапфиры и чёрный чай, иранские шёлковые изделия, шафран и орехи, русская водка и мёд, юго-африканские алмазы и алоэ, итальянское вино и ...

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The objectives of the study were to determine whether retrospective data can be used to answer questions about the efficacy of prokinetic agents when used to treat horses with post-operative ileus (POI). We describe prevalence and mortality of POI with reference to treatment with four prokinetic agents. By combining data from two Hospitals a study population of 55 horses with POI following pedunculated lipoma obstruction (PLO) was established. Univariable and multivariable associations were determined between short term survival and potential explanatory variables. With death as outcome in multivariable models, breed and hospital were significantly associated with outcome but the use of prokinetic agents was not (P=0.15). However, sample size estimates indicate the low power of this study to detect differences in outcome. It was not possible definitively to evaluate the efficacy of prokinetics as treatment for POI following PLO using retrospective data. The data were suggestive of limited ...

Our results indicate that VLBW infants with feed intolerance due to non-anatomically obstructive gastrointestinal dysmotility achieved full enteral feeding significantly earlier after treatment with oral erythromycin. The median times taken to establish half, three quarters, and full enteral nutrition were 3.5, 8.5, and 13.5 days after the start of oral erythromycin. The median times taken to achieve half and full oral feeding in the placebo group were almost twice as long (table2). These findings agree with those of previous case series in preterm infants.13-15 Although a recent randomised controlled study did not show any benefit of intravenous erythromycin in improving the tolerance of enteral feeding in preterm infants,25these findings were not entirely unexpected because the study was not primarily designed to investigate the effectiveness of erythromycin on enteral feeding, but rather focused on the relation between chronic lung disease and intravenous erythromycin treatment for ...

TY - JOUR. T1 - Crohns disease. T2 - Rational management. AU - Picco, Michael F.. PY - 2002. Y1 - 2002. N2 - Crohns disease can involve any part of the digestive tract; it can manifest as inflammatory (diarrhea, abdominal pain, and fever), penetrating (abscess or fistula), or stricturing (recurrent bowel obstruction) disease. Treatment is based on the location and activity of the disease. Mesalamine is recommended to induce and maintain remission in patients with mild to moderate nonpenetrating, nonstricturing disease. Antibiotics may be used as an alternative or adjunct to mesalamine; ciprofloxacin and metronidazole are helpful in fistulizing Crohns disease. For patients with moderate to severe disease, corticosteroids are recommended to induce remission; infliximab is an alternative for those with severe or refractory disease. Remission is then maintained with immunosuppressive therapy, not with corticosteroids. Fistulas are difficult to treat but may respond to antibiotics or azathioprine; ...

Practical and objective instruments to assess pediatric Crohns disease (CD) activity are required for observational research and quality improvement. The objectives were: 1) to determine the feasibility of completing the Pediatric Crohns Disease Activity Index (PCDAI) and the Abbreviated PCDAI (APCDAI); and 2) to create a Short PCDAI by retaining and reweighting the most practical and informative components.

The researchers found that 98% of policies are inconsistent with the AGA ulcerative colitis pathway and require step-wise drug failure before approval of an anti-TNF. Only 11% of the policies allowed starting vedolizumab without initial failures of an anti-TNF agent, and 21% required the failure of 2 or more anti-TNF agents. The team noted that 90% of the policies are inconsistent with AGA Crohns disease pathway, and require step-wise drug failure before approval of an anti-TNF. The research team found that 74% allowed for initiating infliximab specifically for fistulizing Crohns disease. The team observed that 28% required failing of at least 2 or more drugs before starting anti-TNF. Only 8% of policies allowed starting vedolizumab without initial failures of an anti-TNF agent, and 28% required the failure of two anti-TNF agents.. Dr Feuersteins team concludes, The majority of the policies reviewed fail to adhere to the current AGA pathway recommendations for ulcerative colitis and Crohns ...

Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, Rachmilewitz D, Rutgeerts P, Wild G, Wolf DC, Marsters PA, Travers SB, Blank MA, vanDeventer SJ: Infliximab maintenance therapy for fistulizing Crohns disease. N Engl J Med. 2004 Feb 26;350(9):876-85. PMID 14985485 ...

TY - JOUR. T1 - Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab. T2 - A retrospective analysis of the ACCENT i trial. AU - Cornillie, Freddy. AU - Hanauer, Stephen B.. AU - Diamond, Robert H.. AU - Wang, Jianping. AU - Tang, Kezhen L.. AU - Xu, Zhenhua. AU - Rutgeerts, Paul. AU - Vermeire, Séverine. PY - 2014/11/1. Y1 - 2014/11/1. N2 - Background Serum infliximab trough levels correlate with efficacy; dose escalation is often beneficial in patients with Crohns disease who stop responding to infliximab treatment.Objective To carry out a post hoc analysis of A Crohns Disease Clinical Trial Evaluating Infliximab in a New Long-term Treatment Regimen I (ACCENT I) to evaluate the association between serum infliximab trough levels and C-reactive protein (CRP) after 14 weeks of induction treatment with durable sustained long-term response (Crohns Disease Activity Index decrease ≥70 points and ...

Functional Dyspepsia Market. Functional Dyspepsia Market Size is anticipated to increase during the study period owing to the increase in geriatric population and changing dietary habits in the 7MM which increase the cases of FD.. The Functional Dyspepsia market outlook section of the report helps to build a detailed comprehension of the historic, current, and forecasted Functional Dyspepsia market trends by analyzing the impact of current therapies on the market, unmet needs, drivers, and barriers, and demand for better technology. The report gives a thorough detail of the Functional Dyspepsia market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, and view of the key opinion leaders. Functional Dyspepsia Epidemiology. The Functional Dyspepsia epidemiology ...

Prokinetic AgentsProkinetics are promotility agents proposed for use in patients with severe constipation-predominant symptoms. Prucalopride (Motegrity)Prucalopride, a selective 5-hydroxytryptamine (s... more

TY - ABST. T1 - Treatment of Secondary Infliximab Failure in Crohns Disease Based on Serum Levels of Infliximab and Antibodies Against Infliximab. T2 - The Danish Study of Optimizing Infliximab Therapy in Crohns Disease (Do It Crohn) Randomized Clinical Trial. AU - Steenholdt, Casper. AU - Brynskov, Jorn. AU - Thomsen, Ole.. AU - Munck, Lars K.. AU - Fallingborg, Jan. AU - Christensen, Lisbet A.. AU - Pedersen, Gitte. AU - Kjeldsen, Jens. AU - Jacobsen, Bent A.. AU - Oxholm, Anne Sophie. AU - Kjellberg, Jakob. AU - Bendtzen, Klaus. AU - Ainsworth, Mark A.. PY - 2013. Y1 - 2013. U2 - 10.1016/S0016-5085(13)60074-8. DO - 10.1016/S0016-5085(13)60074-8. M3 - Conference abstract in journal. VL - 144. SP - 22 JO - Gastroenterology. JF - Gastroenterology. SN - 0016-5085. IS - 5, Supplement 1. M1 - 94. ER - ...

There is a great need to define molecular mechanisms that underlie (non-)response to anti-TNFα therapy in ulcerative colitis. In this study we investigated endoscopic mucosal biopsy derived mRNA expression to identify a gene expression fingerprint distinguishing primary non-responders from responders and to identify gene panels predictive of response to infliximab, a chimeric IgG1 monoclonal antibody to TNFα.. Two independent cohorts of patients with refractory ulcerative colitis who received a first treatment with infliximab were studied. We classified patients as responders if they achieved complete healing both endoscopically and histologically. All other patients were considered non-responders although some of them showed clinical improvement or showed mucosal healing at a later time point. We used mucosal healing as an endpoint as it is less open to bias than a symptom score, and there is little chance that complete mucosal healing would occur only by spontaneous disease ...

Tolerability of Shortened Infliximab Infusion in Scheduled Maintenance Therapy for IBD: a Prospective Multi-center European Cohort Study

MODEL RELEASED. Infusion pump (Baxter Colleague) used to administer an intravenous (IV) infusion of infliximab into a male patient with Crohns disease. Infliximab is a monoclonal antibody used to treat inflammatory Crohns disease. Sequence of images. - Stock Image C016/8148

Looking for online definition of infliximab in the Medical Dictionary? infliximab explanation free. What is infliximab? Meaning of infliximab medical term. What does infliximab mean?

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...

Reinisch and colleagues (Gut 2006;55:1138-44) recently reported that the infusion of fontolizumab, an anti-interferon γ antibody, into patients with Crohns disease was generally well tolerated with encouraging clinical responses. Unfortunately, not all first trials with therapeutic antibodies go as well as planned. As we recently witnessed with the intravenous administration of TGN1412, designed to activate regulatory T cells for the treatment of leukaemia and autoimmune diseases such as rheumatoid arthritis, six volunteers were hospitalised, four of whom suffered major organ failure. The patients conditions was described as cytokine release syndrome which occurs when activated T cells produce a systemic inflammatory response.. Could the violent reaction to the monoclonal antibody be avoided with oral administration? Ochi et als recent report may offer an answer. They observed that oral was as effective as intravenous administration of anti-CD3 in reversing established experimental ...

AIM: To study the effects of infliximab on pregnancy and foetal outcome. METHODS: We conducted a retrospective chart review of women with Crohns disease treated intentionally with infliximab during pregnancy. The primary outcome measure was the occu

The past three decades have witnessed remarkable advances in our ability to target specific elements of the immune and inflammatory response, fuelled by advances in both biotechnology and disease knowledge. As well as providing superior treatments for immune-mediated inflammatory diseases (IMIDs), such therapies also offer unrivalled opportunities to study the underlying immunopathological basis of these conditions.. In this review, we explore recent approaches to the treatment of IMIDs and the insights to pathobiology that they provide. We review novel biologic agents targeting the T-helper 17 axis, including therapies directed towards interleukin (IL)-17 (secukinumab, ixekizumab, bimekizumab), IL-17R (brodalumab), IL-12/23p40 (ustekinumab, briakinumab) and IL-23p19 (guselkumab, tildrakizumab, brazikumab, risankizumab, mirikizumab). We also present an overview of biologics active against type I and II interferons, including sifalumumab, rontalizumab, anifrolumab and fontolizumab. Emerging ...

Hi, my daughter had her Infliximab infusion last Wed 8th Jan, she has been having them since last May and after the initial loading doses is on an 8 week maintenance. Ella previously had 3 loading doses starting Oct 2012 but they were discontinued due to possible joint pains ( the doctors never came to a conclusion) anyway it was decided after Ella wasnt maintaining on the Aza that she would have to restart. Mostly the infusions have been ok, she has had joint pain (ankle and Knee) but we decided it was the lesser of two evils ...

Thank you for your interest in spreading the word about The Journal of Rheumatology.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...

A recent case series (A Assa et al. JPGN 2020; 71: 516-520. Therapeutic Drug Monitoring-guided High-dose Infliximab for Infantile-onset Inflammatory Bowel Disease: A Case Series) describes four infants (2 mo-12 mo) with infantile-onset IBD who received high doses of infliximab. Treatments regimens utilized infliximab dosing of 10-22 mg/kg/dose with initial three doses over 2-4 weeks.…

A pathway that may contribute to the symptoms related to Crohns disease and ulcerative colitis has been identified by researchers

The primary objective of this study was to demonstrate that tight control of disease activity, using stringent criteria based on Crohns disease activity Index

During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market. ...

This is a randomized, double-blind, placebo-controlled, parallel-group multicenter study of the safety and efficacy of SC regimens of ustekinumab in maintaining disease control through Week 44 in subjects with moderately to severely active Crohns disease induced into clinical response with ustekinumab in the induction studies, CNTO1275CRD3001 or CNTO1275CRD3002. The maintenance portion of the study continues to Week 44 and the subsequent study extension will continue up to Week 272. The number of subjects enrolling in this study will be dependent on the number of subjects from the induction studies eligible to enroll into the maintenance study.. In summary, there is a significant medical need for new safe and effective therapies for moderate to severe, active Crohns disease, particularly in patients who have failed to respond to TNF antagonists. Inhibiting IL-12 and IL-23 and their associated inflammatory pathways via. blockade of the shared IL-12 p40 subunit by ustekinumab constitutes a novel ...

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Management of functional dyspepsia in 2020: a clinical point of view - Minerva Gastroenterologica e Dietologica 2020 December;66(4):331-42 - Minerva Medica - Journals

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Observational Study Evaluating the Effectiveness of Drug Concentration to Predict the Recapture of Response in Crohns Disease Patients With Loss of Response

What is indigestion dyspepsia? It is an impaired digestion with feeling of fullness discomfort after meals without any organic disease.

The Food and Drug Administration (FDA) today approved Humira (adalimumab) to treat adult patients with moderately to severely active Crohns disease, a chronic

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Infliximab è un anticorpo monoclonale che è amministrato per via endovenosa per curare i pazienti con le malattie infiammatorie croniche compreso il morbo di Crohn, la colite ulcerosa, lartrite

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Hello Grateful for any advice. Funding has been put forward to my PCT for Remicade infusions but my hospital warned that the borough I live is notorio...

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Virology is proud to present this Essential Collection of the 30 review articles that we published in 2013 (in addition to our Special Issue on...