Author Summary Frequent outbreaks of acute Chagas disease by food contamination with T. cruzi, characterized by high mortality, have been reported in recent years. In Brazil, oral infection is currently the most important mechanism of T. cruzi transmission. Studies on oral T. cruzi infection in mice have shown that insect-stage metacyclic trypomastigotes invade only the gastric mucosal epithelium and not other areas of mucosal epithelia prior to establishing systemic infection. Here we have shown that metacyclic trypomastigotes bind selectively to gastric mucin, a property also displayed by gp82, a metacyclic stage-specific surface protein implicated in cell adhesion/invasion process. It is also shown that the gastric mucin-binding property of gp82 resides in the central domain of the molecule and that the synthetic peptide p7, based on a gastric mucin-binding sequence of gp82, markedly reduces parasite invasion of cultured human epithelial cells in the presence of gastric mucin. These results, plus
This graph shows the total number of publications written about "Gastric Mucins" by people in this website by year, and whether "Gastric Mucins" was a major or minor topic of these publications ...
MUC5AC (Mucin 5AC / Gastric Mucin) Antibody, Mouse Monoclonal Antibody [Clone MUC5AC/917 ] validated in IHC, IF, FC (AH11914-7), Abgent
MUC5AC (Mucin 5AC / Gastric Mucin) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone 2-11M1 ] validated in IHC-F, IF, FC (AH11917-20), Abgent
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Helicobacter pylori, the gastric pathogen, interacts with gastric mucus layer before colonizing the gastric epithelium. However, such interaction has not been well established. In this study, a novel H. pylori protein (HP0049) has been identified as a mucin binding protein (MBP) as it binds to bovine submaxillary and porcine gastric mucins. The corresponding mbp gene was cloned, expressed, recombinant protein (rMBP) purified and antibody raised. The mucin binding ability of rMBP was inhibited upon pretreatment with neuraminidase and Na-metaperiodate indicating that carbohydrates and sialic acid mediate in the binding of MBP to mucins. Transmission electron microscopy demonstrates that MBP localizes in the cytoplasm close to the cell membrane. Interestingly, sequence analysis revealed MBP to be a potential new member of peptidyl-arginine deiminase (PAD) family as rMBP also displayed PAD activity. ELISA results show significantly higher antibody level against rMBP in patients with non-ulcer ...
Mucous membranes are covered with mucus, a viscoelastic hydrogel that plays an essential role in their protection from shear and pathogens. The viscoelasticity of mucus is owing to mucins, a group of densely glycosylated proteins. Mucins can interact with a wide range of surfaces; thus, there is big interest in exploring and manipulating such interactions for biomedical applications. This thesis presents investigations of mucin interactions with hydrophobic surfaces in order to identify the key features of mucin lubricity, as well as describes the development of materials that are optimized to interact with mucins.. In Paper I we investigated the domains which make mucins outstanding boundary lubricants. The results showed that the hydrophobic terminal domains of mucins play a crucial role in the adsorption and lubrication on hydrophobic surfaces. Specifically, protease digestion of porcine gastric mucins and salivary mucins resulted in the cleavage of these domains and the loss of lubricity and ...
The kinetic adsorption-desorption behaviour of porcine gastric mucin in the presence of physiologically relevant concentrations of the polyphenol epigallocatechin gallate (EGCG) was investigated using high-resolution kinetic optical waveguide lightmode spectroscopy (OWLS) and atomic force microscopy (AFM). Comparison with dynamic light scattering results from EGCG-mucin mixtures indicates that discrete particles are formed whose size increases with increasing EGCG:mucin ratio. These particles are deduced to be the adsorbing entities, which fuse on the surface to form complex surface layers. At low molar EGCG:mucin ratios ...
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies ...
1] Derrien M, Collado MC, Ben-amor K, Salminen S, De vos WM. The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract. Appl Environ Microbiol. 2008;74(5):1646-8.. [2] Earley H, Lennon G, Balfe A, et al. A Preliminary Study Examining the Binding Capacity of Akkermansia muciniphila and Desulfovibrio spp., to Colonic Mucin in Health and Ulcerative Colitis. PLoS ONE. 2015;10(10):e0135280.. [3] Bland J. Intestinal Microbiome, Akkermansia muciniphila, and Medical Nutrition Therapy. Integr Med (Encinitas). 2016;15(5):14-16.. [4] Van passel MW, Kant R, Zoetendal EG, et al. The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes. PLoS ONE. 2011;6(3):e16876.. [5] Wang L, Christophersen CT, Sorich MJ, Gerber JP, Angley MT, Conlon MA. Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism. Appl Environ Microbiol. ...
TY - THES. T1 - Host immunostimulation and substrate utilization of the gut symbiont Akkermansia muciniphila. AU - Ottman, N.A.. N1 - WU thesis 6129. PY - 2015. Y1 - 2015. N2 - Host immunostimulation and substrate utilization of the gut symbiont Akkermansia muciniphila Noora A. Ottman The human gastrointestinal tract is colonized by a complex community of micro-organisms, the gut microbiota. The majority of these are bacteria, which perform various functions involved in host energy metabolism and immune system stimulation. The field of gut microbiology is continuously expanding as novel species are isolated and high-throughput techniques are developed. The research focus is shifting from DNA-based techniques, looking at microbial community composition, to techniques relying on analysis of RNA and proteins, which reveal more about the activity and functionality of the microbiota. The mucosa-associated microbiota forms a distinct population in the gut, and is influenced by the close proximity of ...
The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia that can be cultured in vitro, A. muciniphila is much easier to detect by metagenomic analysis of intestinal flora. In the past few years, A. muciniphila has been getting increasing attention for the positive correlation between its intestinal colonization and host homeostatic metabolism. In this review, we summarize the relationship between A. muciniphila and host health and diseases, especially focusing on metabolic diseases and related mechanisms, as well as the natural food and drug-derived substrates affecting its colonization in the host, expecting to provide evidence and clues for the development of drugs targeting A. muciniphila. Copyright © 2019 China Pharmaceutical ...
It is becoming more and more apparent that the composition of the gut microbiota affects human health and is associated with different diseases conditions including inflammatory bowel diseases (IBDs), metabolic syndrome and obesity. Currently, it is not yet known whether alterations in the microbiota are a cause or an effect of such diseases.. Akkermansia muciniphila (A. muciniphila) is a gram-negative, mucin-degrading bacterium and is naturally present in the human microbiota. It represents 3-5 % of the bacterial population in a healthy person. A. muciniphila is located in special areas of the human mucosa and can be detected in stool samples of infants from the age of less than beeing one month. Afterwards, the quantity of A. muciniphila increases with age. In elderly people numbers of A. muciniphila are significantly reduced. A. muciniphila can be partially associated with diabetes, adiposity and Inflammatory Bowel Disease (IBD).. ...
Background The human gastrointestinal tract contains a complex community of microbes, fulfilling important health-promoting functions. However, this vast complexity of species hampers the assignment of responsible organisms to these functions. Recently, Akkermansia muciniphila, a new species from the deeply branched phylum Verrucomicrobia, was isolated from the human intestinal tract based on its capacity to efficiently use mucus as a carbon and nitrogen source. This anaerobic resident is associated with the protective mucus lining of the intestines. Methodology/Principal Findings In order to uncover the functional potential of A. muciniphila, its genome was sequenced and annotated. It was found to contain numerous candidate mucinase-encoding genes, but lacking genes encoding canonical mucus-binding domains. Numerous phage-associated sequences found throughout the genome indicate that viruses have played an important part in the evolution of this species. Furthermore, we mined 37 GI tract metagenomes
The diversity of mucin-degrading bacteria in the human intestine was investigated by combining culture and 16S rRNA-dependent approaches. A dominant bacterium, strain MucT, was isolated by dilution to extinction of faeces in anaerobic medium containing gastric mucin as the sole carbon and nitrogen s …
LaBrec, Eugene H., Herman Schneider, Thomas J. Magnani, and Samuel B. Formal. Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J. Bacteriol. 88:1503-1518. 1964.-A parent strain of Shigella flexneri 2a and a colonial mutant derived from it were studied in three animal models. Both strains were equally virulent for mice when living cells suspended in hog gastric mucin were injected by the intraperitoneal route. Feeding the parent strain to starved guinea pigs, followed by the intraperitoneal injection of opium, resulted in the formation of ulcerative lesions in the intestinal tract and in the death of these animals. When the colonial variant was fed to similarly prepared animals, the animals survived and the intestinal tract remained normal. The parent produced diarrheal symptoms and intestinal lesions after its oral administration to rhesus monkeys; the variant caused neither symptoms nor pathology in this species. Studies were carried out to define the ...
Several genes encoding ribosomal proteins, tRNA-charging proteins, and most amino acid biosynthesis pathways were upregulated during growth on mucin compared with those during growth on glucose. Sampling times were selected to capture the mid-exponential growth phase (see Fig. S1). However, because of the specialization of A. muciniphila in mucin degradation, the growth rate on mucin is higher than on the other media, which is reflected in the upregulation of genes associated with the indicated translation processes. Biosynthesis pathways for cysteine, proline, glutamate, and glutamine were downregulated. Since both cysteine and proline are highly abundant in the mucin protein backbone, this likely reflects the uptake of these amino acids. Interestingly, the incorporation of ammonia via glutamine synthase (Amuc_1252) was downregulated under mucin conditions, indicating a reduced requirement for ammonia assimilation.. Glutamate decarboxylase (Amuc_0372) was significantly upregulated in glucose ...
The early postnatal period is a critical time for microbial protection from type 1 diabetes and it is suggested that the mucolytic bacterium A. muciniphila plays a protective role in autoimmune diabetes development, particularly during infancy.
The aim of this study was to assess the profile of mucins (MUC1, MUC2, MUC5AC) in the intestinal metaplasia (IM) of the gastric mucosa through the immunohistochemical method.. Methods: To identify the metaplastic areas in the gastric mucosa, chromoendoscopy was employed using 0.5% solution of methylene blue. The expression of the profile of the mucins was determined using immunohistochemistry with MUC1, MUC5AC, and MUC2 antibodies (clone Ma695, clone CLH2, Ccp58 and CLH5, "Novocastra "Great Britain).. Results: In the regions adjacent to the adenocarcinoma and neoplastic modified cells, a visible weak expression of MUC2 and MUC5AC was observed. In the case of complete IM, a visibly maximum MUC2 expression was observed in the goblet cells; thus, the MUC5AC, MUC1, and MUC6 marking were absent in the columnar epitheliocytes with the brush border. In the case of incomplete IM, along with the positive MUC2 markings of the goblet cells, the presence of gastric mucin (MUC5AC) has been observed in 25% of ...
Willem de Vos © Bram Belloni. For this purpose the company makes use of the bacterium Akkermansia muciniphila, which was more or less accidentally discovered in 2004 by professor of Microbiology Willem de Vos. De Vos and Belgian professor Patrice Cani set up the company A-mansia in 2016, and within a year they had acquired the necessary starting capital of 13 million euros. And now they are getting another five million from the investment fund Innovation Industries. Prescribing Akkermansia muciniphila helps combat overweight and probably other diseases such as fatty liver disease and bowel infections. But you shouldnt treat it as a solution to an unhealthy diet and lack of exercise, says De Vos. By prescribing the bacteria you shift the tipping point a little and the patient doesnt become overweight as quickly.. The advantage of this bacterium is that it works in its pasteurized form too, which makes it safe to add to food products. There are still a lot of uncertainties surrounding the ...
The influenza virus NA, which is important for virus release from cells, also aids in infection by degrading the mucus barrier of the respiratory tract.
Lets understand the parts so we can understand the whole," he said.. Akkermansia muciniphila stands out because it sustains itself by consuming mucin, the main component of the mucus our bodies produce to, among other things, protect our cells. As Akkermansia consume mucin, they help signal our bodies to produce more, thus helping to maintain this protective barrier.. Flores lab is studying how Akkermansia interacts with the host and other organisms in the gut. Akkermansia is largely thought of as a keystone species, a species on which other species in an ecosystem - in this instance, the human gut - largely depend. If a keystone species was removed or its abundance was significantly altered, the ecosystem could be impacted dramatically.. Flores noted that Akkermansia play a role in every stage of human development, from helping infants digest breastmilk and other nutrients to helping adults regulate blood glucose levels. Given that role, Flores said health food manufacturers are keen to add ...
General Information: This organism was isolated from human feces and is able to degrade mucin. Loss of this protective barrier may expose the gastrointestinal epithelial cells to pathogenic microorganisms or to the highly acidic gut environment. Akkermansia muciniphila is a member of the Verrucomicrobia which are also common in soil and water. ...
An academic study, Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity, used a fiber to reduce fat in obese mice…
By distributing receptor-binding and receptor-destroying proteins asymmetrically on their surface, filamentous influenza A virus particles create a Brownian ratchet that facilitates their passage through mucus.
Author(s): Ren, Binhui; Azzegagh, Zoulikha; Jaramillo, Ana M; Zhu, Yunxiang; Pardo-Saganta, Ana; Bagirzadeh, Rustam; Flores, Jose R; Han, Wei; Tang, Yong-Jun; Tu, Jing; Alanis, Denise M; Evans, Christopher M; Guindani, Michele; Roche, Paul A; Rajagopal, Jayaraj; Chen, Jichao; Davis, C William; Tuvim, Michael J; Dickey, Burton F | Abstract: Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared to ciliated and basal cells of airway epithelium by immunohistochemistry and fluorescence activated cell sorting, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are release from perfused tracheas of mutant and wild-type mice at the same rate, suggesting that increased
In this article we will be discussing the production of gastric mucus in the stomach. We will be looking at the cells that make up the mucosa of the stomach, the process of producing mucus, the control mechanisms involved in its secretion and some clinical aspects of when things go wrong.
The use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting anti-inflammatory effects. The abundance of A. muciniphila is associated with a healthy gut in early mid- and later life. However, the effects of A. muciniphila on a decline in intestinal health during the aging process are not investigated yet. We supplemented accelerated aging Ercc1−/Δ7 mice with A. muciniphila for 10 weeks and investigated histological, transcriptional and immunological aspects of intestinal health. The thickness of the colonic mucus layer increased about 3-fold after long-term A. muciniphila supplementation and was even significantly thicker compared to mice supplemented with Lactobacillus plantarum WCFS1. Colonic gene expression profiles pointed towards a decreased expression of genes and pathways related to inflammation and immune function, and suggested a decreased
An experimental murine infection was established by the intraperitoneal injection of a log-phase culture of a laboratory reference strain of Streptococcus agalactiae, Lancefield group B, type III (strain SS620), suspended in sterile hog gastric mucin. The enhancement of streptococcal virulence was measured by a significantly increased mortality in outbred ICR Swiss mice. An inbred C57BL6 strain of mice was resistant to the mucin-bacterial combination. Mucin, treated with Desferal to chelate the iron, did not lose the capacity to enhance the virulence of group B, type III streptococci in ICR Swiss mice. Iron-dextran was not a suitable substitute for mucin and failed to enhance the virulence of group B, type III streptococci. The results of these studies indicate that iron is not the resistance-lowering factor in this group B, type III streptococci-mucin model. ...
Funding This work was supported by Christian Doppler Research Society (to HT). HT is supported by the excellence initiative (Competence Centers for Excellent Technologies) of the Austrian Research Promotion Agency FFG: Research Center of Excellence in Vascular Ageing Tyrol, VASCage (K:Project Nr. 843536) funded by the Bundesministerium für Verkehr, Inovation und Technologie (BMVIT), Bundesministerium für Wissenschaft, Forschung und Wirtschaft (BMWFW), the Wirtschaftsagentur Wien and the Standortagentur Tirol. TEA is supported by the Austrian Science Fund (FWF) P 29379:B28 and the Tyrolian Science Fund (TWF) 0404/1812. GS and PL were supported by R01 AA017729 from the National Institute on Alcoholism and Alcohol Abuse, USA. ...
The role of H. pylori in the creation of stomach ulcers as been well studied in recent years. Within the stomach, the bacteria produces urease: converting urea to ammonia and raises the pH. The less acidic environment reduces the viscosity of the gastric mucin, allowing the bacteria to move through it[4] and attach to the stomach wall. Once there, it gains protection from the harsh environment of the stomach[5] and produces cytotoxic factors that lead to the formation of ulcers[6]. The function of NSAIDs in the cause of ulcers is also well understood. Typical NSAIDs work by inhibiting cyclooxygenase, an enzyme responsible for the production of the hormone prostaglandin. Without prostaglandin, the stomach fails to produce sufficient mucus, and produces excess acid[5]. Apart from H. pylori and NSAIDs there are ideopathic ulcers-those with no specifically known cause. A review by Iijima et al.[7], noted that various studies recorded rates of ideopathic ulcers ranging from 4-40\%. It may be ...
Epithelial cells of the mammalian intestine are covered with a mucus layer that prevents direct contact with intestinal microbes but also constitutes a substrate for mucus-degrading bacteria. To study the effect of mucus degradation on the host response, germ-free mice were colonized with Akkermansia muciniphila. This anaerobic bacterium belonging to the Verrucomicrobia is specialized in the degradation of mucin, the glycoprotein present in mucus, and found in high numbers in the intestinal tract of human and other mammalian species. Efficient colonization of A. muciniphila was observed with highest numbers in the cecum, where most mucin is produced. In contrast, following colonization by Lactobacillus plantarum, a facultative anaerobe belonging to the Firmicutes that ferments carbohydrates, similar cell-numbers were found at all intestinal sites. Whereas A. muciniphila was located closely associated with the intestinal cells, L. plantarum was exclusively found in the lumen. The global ...
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gastric mucus glycoproteins: from glandular region of gastric mucosa; high molecular wt. glycoproteins consisting of large numbers of carbohydrate side chains attached to protein core through O-glycosidic linkages; possibly protects stomach from ulceration
The aqueous environment in the gastrointestinal tract frequently requires solubilization of hydrophobic drug molecules in appropriate drug delivery vehicles. An effective uptake/absorption and systemic exposure of a drug molecule entails many processes, one being transport properties of the vehicles through the mucus layer. The mucus layer is a complex mixture of biological molecules. Among them, mucin is responsible of the gel properties of this layer. In this study, we have investigated the diffusion of polyoxyethylene sorbitane monooleate (polysorbate 80), a commonly used nonionic surfactant, in aqueous solution, in mucin solutions at 0.25 and 5 wt %, and in mucus. These measurements were done by using the pulsed field gradient spin echo nuclear magnetic resonance (PGSE-NMR) technique. We conclude that polysorbate 80 is a mixture of non-surface-active molecules that can diffuse freely through all the systems investigated and of surface-active molecules that form micellar structures with transport
Figure 1. Yearly number of publication related to mucins as reported by scicurve.com, using the keyword "mucins".. This is because mucin research spans over many fields. Biologists have been intrigued by mucins since long. But more recently, microbiologists studying our microbiome have new reasons to find this class of biopolymers particularly exciting. For instance, they realized that intestinal mucus plays key roles in the behavior of both pathogenic and commensal bacteria. This will surely lead to many more microbiology studies with mucus/mucins as a key component (1,2). Similarly, recent findings in immunology describing interactions between dendritic cells and mucin-associated glycans will also attract attention to secreted mucins in that field (3).. Some physicists and biophysicists are also fascinated by mucins. Tribologists are trying to understand and recreate mucins efficient lubricity that is so precious for a healthy mouth and gastrointestinal tract (4,5). The field of oral drug ...
Gastric cancer (GC) is one of the most common malignancies worldwide. Better knowledge of the changes in gene expression that occur during gastric carcinogenesis may lead to improvements in diagnosis, treatment and prevention. In this study, we screened for genes upregulated in GC by comparing gene expression profiles from microarray and serial analysis of gene expression and identified the HOXA10 gene. The aim of the present study was to investigate the significance of HOXA10 in GC. Immunohistochemical analysis demonstrated that 221 (30%) of 749 GC cases were positive for HOXA10, whereas HOXA10 was scarcely expressed in non-neoplastic gastric mucosa except in the case of intestinal metaplasia. Next, we analyzed the relationship between HOXA10 expression and clinicopathological characteristics. HOXA10 expression showed a significant inverse correlation with the depth of invasion and was observed more frequently in the differentiated type of GC than in the undifferentiated type of GC. HOXA10 ...
The sustained delivery of both hydrophobic and hydrophilic drugs from hydrogels remains a challenge that requires the design of complex multifunctional synthetic polymers. In this work we exploit mucin glycoproteins, the gel-forming building blocks of natural mucus to deliver both hydrophobic and hydrophilic drugs. Mucins are a family of high molecular weight proteins which are densely glycosylated. Their central protein backbone contains hydrophobic and charged domains, while the mucin-associated glycans provide hydrogen bonding capabilities, high hydration, and negative charges. The biochemical versatility of mucins represents potential binding sites for certain drugs. If assembled into hydrogels, mucins could prevent drugs from freely diffusing out, leading to their sustained delivery. We generated methacrylated mucins which assembled into a covalently crosslinked mucin hydrogel when exposed to UV light. The rheological properties of the mucin gels were dominated by an elastic component, and ...
Experiment with focus on mucin. In 2009 Yana Znamenskaya Falk moved to Sweden for a PhD study at Malmö University. In her PhD Yana chose to focus on the effect of hydration on the structural, thermodynamic and rheological properties of biopolymer mucin, which is a main component of mucus. Mucus is a slippery secretion produced by, and covering, mucous membranes. Yana is currently working at Biofilms, Research Center for Biointerfaces, at Malmö University where she has continued her research study on mucin. In 2016 Yana participated in an experiment project within MAX4ESSFUN.. Yana explains that mucus consists primarily of water (95%), the glycoprotein mucin and other components and it can be found in all internal tracts of the body, f. ex. the mouth, nose, throat, sinuses, stomach and lungs. One of the essential functions of the mucous gel is protection of tissues against dehydration (drying). In order to fulfil this function, the mucous gel should be strongly hydrated, i.e. it should contain ...
Pharmacology Basics Definitions • Pharmacokinetics вЂ" The process by which a drug is absorbed, distributed, metabolized and eliminated by the body • Pharmacodynamics вЂ" The interactions of a drug and the receptors responsible for its action in the body The Life Cycle of a Drug (pharmacokinetics) • • • • Absorption Distribution Degradation Excretion Slow Absorption • Orally (swallowed) • through Mucus Membranes вЂ" Oral Mucosa (e.g. sublingual) вЂ" Nasal Mucosa (e.g. insufflated) • Topical/Transdermal (through skin) • Rectally (suppository) Faster Absorption • Parenterally (injection) вЂ" Intravenous (IV) вЂ" Intramuscular (IM) вЂ" Subcutaneous (SC) вЂ" Intraperitoneal (IP) • Inhaled (through lungs) Fastest Absorption • Directly into brain вЂ" Intracerebral (into brain tissue) вЂ" Intracerebroventricular (into brain ventricles) General Principle: The faster the absorption, the quicker the onset, the higher the ...
In biological systems, polymeric materials block the movement of some macromolecules while allowing the selective passage of others. We developed a model motivated by features of the nuclear pore complex (NPC) which are highly conserved and could potentially be applied to other biological systems. We show that a single feature of the NPC is sufficient for selective transport: the bound-state motion resulting from transient binding to flexible filaments. We generalized this observation to model nanoparticle transport through mucus as well. Our model provides a framework to control binding- induced selective transport in biopolymeric materials.. ...
TY - JOUR. T1 - Mechanistic and functional shades of mucins and associated glycans in colon cancer. AU - Pothuraju, Ramesh. AU - Krishn, Shiv Ram. AU - Gautam, Shailendra K.. AU - Pai, Priya. AU - Ganguly, Koelina. AU - Chaudhary, Sanjib. AU - Rachagani, Satyanarayana. AU - Kaur, Sukhwinder. AU - Batra, Surinder K.. PY - 2020/3. Y1 - 2020/3. N2 - Mucus serves as the chief protective barrier against pathogenic and mechanical insults in respiratory, gastrointestinal, and urogenital tracts. Altered mucin expression, the major component of mucus, in conjunction with differential glycosylation has been strongly associated with both benign and malignant pathologies of colon. Mucins and their associated glycans arbitrate their impact sterically as well as mechanically by altering molecular and microbial spectrum during pathogenesis. Mucin expression in normal and pathological conditions is regulated by nonspecific (dietary factors and gut microbiota) and specific (epigenetic and transcriptional) ...
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Mucins are high molar mass glycoproteins that assume an extended conformation and can assemble into mucus hydrogels that protect our mucosal epithelium. In nature, the challenging task of generating a mucus layer, several hundreds of micrometers in thickness, from micrometer-sized cells is elegantly solved by the condensation of mucins inside vesicles and their on-demand release from the cells where they suddenly expand to form the extracellular mucus hydrogel. We aimed to recreate and control the process of compaction for mucins, the first step toward a better understanding of the process and creating biomimetic in vivo delivery strategies of macromolecules. We found that by adding glycerol to the aqueous solvent, we could induce drastic condensation of purified mucin molecules, reducing their size by an order of magnitude down to tens of nanometers in diameter. The condensation effect of glycerol was fully reversible and could be further enhanced and partially stabilized by cationic ...
Snail Mucin (yes, snail slime) What I want to know is- Who was the first person to put this on their face? Why should YOU be interested? Below are some of the claims Ive found for snail mucin through articles, cosmetic brands & ingredient companies. However, I only found one clinical study, and the one…
Cosrx Advanced Snail 96 Mucin Power Essence is a powerful anti-ageing cream with 96% Mucin. This skin-friendly snail extract repairs dry and damaged skin cells.
A critical function of mucin in saliva is to protect the mouth from drying out. Mucin also lubricates the tissues and teeth in the mouth and protects them against pathogens and...
Page contains details about mucin nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
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