Introduction:Ganglioneuroblastoma is a rare peripheral neuroblastic tumor that is derived from developing neuronal cells of the sympathetic nervous system, and is found mostly, but not exclusively, in babies and young children. Case Presentation: To the best of our knowledge, there have been no previously reported cases of ganglioneuroblastoma of the mediastinum from Pakistan. We present a case of ganglioneuroblastoma in an eight-year-old Pakistani Sindhi boy incidentally found to have a large posterior mediastinal mass that on biopsy initially looked like ganglioneuroma. He underwent successful excision of the mediastinal mass and remained stable post-operatively. Final pathology findings showed a ganglioneuroblastoma. He has remained free of symptoms on long-term follow-up. Conclusions: The rarity of this tumor along with its almost exclusive occurrence in the pediatric population necessitates a thorough investigation of Patients presenting with a symptomatic mass.
Clinical trial for Stage 4S Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Disseminated Neuroblastoma | Localized Resectable Neuroblastoma | Stage 4 Neuroblastoma | Ganglioneuroblastoma , Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
Clinical trial for Stage 4S Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Disseminated Neuroblastoma | Localized Resectable Neuroblastoma | Stage 4 Neuroblastoma | Ganglioneuroblastoma , Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
TY - JOUR. T1 - Age, Diagnostic Category, Tumor Grade, and Mitosis-Karyorrhexis Index Are Independently Prognostic in Neuroblastoma. T2 - An INRG Project. AU - Sokol, Elizabeth. AU - Desai, Ami V.. AU - Applebaum, Mark A.. AU - Valteau-Couanet, Dominique. AU - Park, Julie R.. AU - Pearson, Andrew D.J.. AU - Schleiermacher, Gudrun. AU - Irwin, Meredith S.. AU - Hogarty, Michael. AU - Naranjo, Arlene. AU - Volchenboum, Samuel. AU - Cohn, Susan L.. AU - London, Wendy B.. PY - 2020. Y1 - 2020. N2 - PURPOSE The Childrens Oncology Group (COG) stratifies the treatment of patients with neuroblastoma on the basis of a combination of biomarkers that include age and tumor histology classified by age-linked International Neuroblastoma Pathology Classification (INPC) criteria. By definition, this leads to a duplication of the prognostic contribution of age. The individual histologic features underlying the INPC have prognostic strength and are incorporated in the International Neuroblastoma Risk Group ...
The above features suggested a chronic infective spondylitis, most likely tuberculosis of the spine with compression. The differential diagnosis was atypical mycobacterial or fungal infection. Therefore, biopsy and decompression of the cord was done through a left-sided costo-transversectomy of the dorsolumbar junction. Granulation material compressing the conus medullaris was noted. Histopathologic examination of a biopsy specimen of this mass demonstrated features consistent with the diagnosis of a retroperitoneal ganglioneuroblastoma of the spine. Ultrasound and MRI revealed no lesions in the adrenals and retroperitoneum. The patient was commenced on chemotherapy and radiotherapy. She currently remains Frankel C one year postoperatively.. Discussion. Tuberculosis is common in the developing world. According to the World Health Organization (WHO), more than 2 billion people, equal to one-third of the worlds population, are infected with the tuberculous bacillus. Spinal tuberculosis accounts ...
TY - JOUR. T1 - Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status. AU - Giannini, G.. AU - Kim, C. J.. AU - Marcotullio, L. Di. AU - Manfioletti, G.. AU - Cardinali, B.. AU - Cerignoli, F.. AU - Ristori, E.. AU - Zani, M.. AU - Frati, L.. AU - Screpanti, I.. AU - Gulino, A.. PY - 2000. Y1 - 2000. N2 - HMGI and HMGY are splicing variants of the HMGI(Y) gene and together with HMGI-C, belong to a family of DNA binding proteins involved in maintaining active chromatin conformation and in the regulation of gene transcription. The expression of the HMGI(Y) gene is maximal during embryonic development, declines in adult differentiated tissues and is reactivated in most transformed cells in vitro and in many human cancers in vivo. The HMGI(Y) genomic locus is frequently rearranged in mesenchymal tumours, suggesting a biological role for HMGI(Y) gene products in tumour biology. HMGIs are both target and modulators of retinoic acid activity. In ...
PRIMARY OBJECTIVES:. I. To prospectively analyze the factors that are currently used for risk-group assignment (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog [MYCN] copy number by fluorescent in situ hybridization [FISH], deoxyribonucleic acid [DNA] content by flow cytometry, and tumor histology using the International Neuroblastoma Pathologic Classification System) in neuroblastoma tumors at the time of diagnosis.. II. To maintain a reference bank containing clinically and genetically characterized frozen tumor tissue, tumor DNA and ribonucleic acid (RNA), histology slides and paraffin blocks, neuroblastoma-derived cell lines, patient serum and paired normal DNA obtained at the time of diagnosis, at the time of second-look surgery and at the time of relapse for future research studies.. III. To prospectively analyze 1p, 11q, 14q and 17q allelic status, MYCN copy number by quantitative polymerase chain reaction (PCR); and the expression pattern of neurotrophin-related ...
Suganuma Rie, Wang Larry L, Sano Hideki, Naranjo Arlene, London Wendy B, Seeger Robert C, Hogarty Michael D, Gastier-Foster Julie M, Look A Thomas, Park Julie R, Maris John M, Cohn Susan L, Amann Gabriele, Beiske Klaus, Cullinane Catherine J, dAmore Emanuele S G, Gambini Claudio, Jarzembowski Jason A, Joshi Vijay V, Navarro Samuel, Peuchmaur Michel, Shimada Hiroyuki. Peripheral neuroblastic tumors with genotype-phenotype discordance: A report from the Childrens Oncology Group and the International Neuroblastoma Pathology Committee. Pediatric Blood & Cancer. Vol 60(3) . 2013 Mar:363-70 ...
Respiratory distress is a very common problem in newborns. It can be due to several causes, notably pneumonia, sepsis, heart disease, congenital anomalies of the respiratory tract, and so on. GNB is a rare tumor in the newborn period. Rarer still is GNB presenting with respiratory distress. Most cases present before 10 years of age. After a literature search, we could find only one case which had presented at birth and another case at 13 days of life [2]. GNB arises from the sympathetic chain; anywhere from the adrenal medulla to the paravertebral sympathetic ganglia. The most common sites of origin are adrenal medulla (35%), extra-adrenal retroperitoneum (30-35%) and posterior mediastinum (20%) [3]. In 1981, Adam et al. reported a series of 80 cases all of which arose from the posterior mediastinum [2]. Rarely, they can be found in other sites, for example, neck, pelvis, lungs, nervous system and so on [3-8]. The mode of presentation depends on the area of involvement; they may present with ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
List of all the English words with 20 letters finishing by A. abetalipoproteinemia, achondroplasiaphobia, cholangiocarcinomata, cystadenocarcinomata, dermoodontodysplasia, dysgammaglobulinemia, ganglioneuroblastoma, gynandromorphophilia, hebesphenomegacorona
Both the prognosis and choice of treatment depend on the extent of the disease when it is diagnosed.. The TNM classification system is used to stage lung cancer and classify the size and extent of the disease at the time of the diagnosis. "T" describes the size and extent of the local tumor. "N" (node) expresses whether there is metastasis to lymph nodes. "M" expresses the absence or presence of distant metastasis (23). The TNM system differentiates between the clinical classification based on radiology and clinical examination (cTNM), and the pathology classification (pTNM). Only patients treated with surgery are staged according to pTNM, while patients treated by radiation therapy or chemotherapy are staged according to cTNM. The TNM classification is critical for the choice of treatment and must be present before treatment is initiated. However, if distant metastases are present (M1), the T and N stages are of minor importance.. ...
TY - JOUR. T1 - Survival of patients with carcinoma in situ of the urinary bladder. AU - Cheng, Liang. AU - Cheville, John C.. AU - Neumann, Roxann M.. AU - Leibovich, Bradley C.. AU - Egan, Kathleen S.. AU - Spotts, Bruce E.. AU - Bostwick, David G.. PY - 1999/6/1. Y1 - 1999/6/1. N2 - BACKGROUND. To the authors knowledge, the long term follow-up of patients with carcinoma in situ of the urinary bladder is limited. METHODS. The authors studied 138 patients diagnosed with urothelial carcinoma in situ of the bladder at the Mayo Clinic between 1972-1979. All the histologic slides were reviewed and fulfilled the diagnostic criteria for carcinoma in situ according to the newly proposed World Health Organization and International Society of Urologic Pathology classification system. None of these patients had previous or coexisting invasive urothelial carcinoma at the time of diagnosis. Cox proportional hazards models were used to determine the prognostic significance of numerous clinical and ...
Copyright © 2008 Saunders, An Imprint of Elsevier C CABG (see Coronary artery bypass graft ) Cachexia (see Kwashiorkor or Marasmus ) Calculi (see Renal calculi or Biliary calculi ) Cancer (See Brain tumors , Breast cancer , Cervical cancer , Colon cancer , Endocrine tumors , Esophageal cancer , Ganglioneuroblastoma , Gastric cancer , Glucagonoma , Head and neck cancer , Hepatomas , Insulinoma , Leukemia , Liver cancer , Lung cancer , Lymphoma , Melanoma , Metastasis , Multiple myeloma , Neuroblastoma , Ovarian cancer , Pancreatic cancer , Pheochromocytoma , Prostate cancer , Renal cell cancer , Sarcoma , Testicular cancer , Thyroid cancer , Uterine cancer , Vaginal cancer , or Wilms tumor ) Candidiasis (see Thrush , Vaginitis ) Cannabis Drug Abuse (see Drug abuse ) Carbohydrate-Deficient Glycoprotein S yndrome • Transferrin, Carbohydrate-deficient, Serum Carbon Monoxide Poisoning Bicarbonate, Blood • Blood gases, Arterial, Blood (Oxygen saturation) • Carbon monoxide, Blood ...
AIMS: Neuroblastoma shows considerable histological overlap with other small round blue cell tumours. PHOX2B, a transcription factor that is essential for autonomic nervous system development, has been reported as an immunohistochemical marker for neuroblastoma. The aim of this study was to validate the specificity and diagnostic utility of PHOX2B for peripheral neuroblastic tumours. METHODS AND RESULTS: We evaluated 240 cases (133 in whole-tissue sections; 107 in tissue microarrays), including 76 peripheral neuroblastic tumours (median age 2 years; including four adults) and 164 other tumours: 44 Wilms tumours; 20 Ewing sarcomas; 10 each of CIC-rearranged round cell sarcomas, poorly differentiated synovial sarcomas, lymphoblastic lymphomas, alveolar rhabdomyosarcomas, embryonal rhabdomyosarcomas, mesenchymal chondrosarcomas, Merkel cell carcinomas, olfactory neuroblastomas, and melanomas; and five each of NUT midline carcinomas and desmoplastic small round cell tumours ...
Cancer cells have an altered distribution of DNA methylation relative to normal cells. We have shown previously that human cancer cells express aberrant DNMT3B transcripts via abnormal gene splicing. Many of these aberrant transcripts encode truncated proteins, including DNMT3B7, one of the most commonly expressed aberrant isoforms expressed in cancer. In vitro, DNMT3B7 expression modifies the pattern of DNA methylation and gene expression. Neuroblastoma is a pediatric tumor of the neural crest cell lineage. A clinically aggressive disease and poor outcome is associated with CpG island methylator phenotype in neuroblastoma. We found that the expression of four or more DNMT3B transcripts, in primary neuroblastic tumors correlated with high-risk and stage IV disease. Further, the expression of ΔDNMT3B5 also correlated to high-risk and stage IV tumors. Additionally, higher levels of DNMT3B7 expression were detected in more differentiated neuroblastic tumors (ganglioneuroblastomas) compared to ...
Paraspinal ganglioneuromas are extremely rare. Like neuroblastomas and ganglioneuroblastomas, ganglioneuromas are derived from the primordial neural crest cells that form the sympathetic nervous system. Please refer to ganglioneuroma for a more ...
This line was derived by A.F. Gazdar, H.K. Oie, J.D. Minna and associates from a bone marrow metastasis taken from a patient prior to therapy.
In neuroblastic tumors a relationship of differentiation of the tumor to galanin receptor expression and antiproliferative and apoptotic effects upon activation of galanin receptors in neuroblastoma cells was reported. To elucidate the expression of other components of the galanin peptide family in neuroblastic tumors, RT-PCR analysis of a variety of human neuroblastic tumor tissues was performed. Ganglioneuroma tissues revealed the presence of a splice variant of the galanin-like peptide (GALP) mRNA, which results in exclusion of exon 3 and a frame shift after the signal peptide sequence of GALP. This generates a peptide of 25 amino acids, which we have termed alarin because of the N-terminal alanine and the C-terminal serine. The novel neuropeptide alarin does not reveal significant homology to other peptides. Immunohistochemistry with antibodies directed against synthetic alarin peptide detected specific cytoplasmic granular staining in ganglia of human ganglioneuroma and ...
In neuroblastic tumors a relationship of differentiation of the tumor to galanin receptor expression and antiproliferative and apoptotic effects upon activation of galanin receptors in neuroblastoma cells was reported. To elucidate the expression of other components of the galanin peptide family in neuroblastic tumors, RT-PCR analysis of a variety of human neuroblastic tumor tissues was performed. Ganglioneuroma tissues revealed the presence of a splice variant of the galanin-like peptide (GALP) mRNA, which results in exclusion of exon 3 and a frame shift after the signal peptide sequence of GALP. This generates a peptide of 25 amino acids, which we have termed alarin because of the N-terminal alanine and the C-terminal serine. The novel neuropeptide alarin does not reveal significant homology to other peptides. Immunohistochemistry with antibodies directed against synthetic alarin peptide detected specific cytoplasmic granular staining in ganglia of human ganglioneuroma and ...
Hello! The term neuroblastoma is commonly used to refer to a spectrum of neuroblastic tumors (including neuroblastomas, ganglioneuroblastomas, and ganglioneuromas) that arise from primitive sympathetic ganglion cells and, like paragangliomas and pheochromocytomas, have the capacity to synthesize and secrete catecholamines.. Remember the N myc mnemonic for neuroblastoma :. N - Neuroblastoma, N myc ...
International Neuroblastoma Research and Collaboration for Effective Delivery (INBRACED) is a new collaboration between charities, researchers and clinicians with the shared aim of accelerating the development of new, more effective therapies for the childhood cancer neuroblastoma.Central to the groups activities is the introduction of standardised, international clinical trials.
International Neuroblastoma Research and Collaboration for Effective Delivery (INBRACED) is a new collaboration between charities, researchers and clinicians with the shared aim of accelerating the development of new, more effective therapies for the childhood cancer neuroblastoma.Central to the groups activities is the introduction of standardised, international clinical trials.
Stage IV-S and International Neuroblastoma Staging System stage 4S were 98% concordant. MYCN was not amplified in any of the tumors tested (n = 58), and Shimada histopathologic classification was favorable in 96% (n = 68/71). The 5-year event-free survival (EFS) rate for all infants was 86% and the survival rate was 92%. Supportive care was the only treatment provided for 44 (55%) of 80 infants, and their 5-year survival rate was 100%, compared with 81% survival for those requiring cytotoxic therapy for symptoms (P =.005). Five of six deaths were in infants younger than 2 months of age at diagnosis and were due to complications of extensive abdominal involvement with respiratory compromise or disseminated intravascular coagulation. Although age ,/= 3 months at diagnosis was significant for EFS (P =. 043), it was less significant for survival (P =.077). The only other significant factor predictive for improved survival was favorable Shimada histopathologic classification. Sites of metastatic ...
Established from a bone marrow metastasis of a 42-month-old boy with stage IV neuroblastoma after 6 months of chemotherapy. IFN gamma inhibits growth of GIMEN. FGF-2 is antimitogenic for GIMEN cells, this antimitogenic effect of FGF-2 is reversed by IFN gamma and enhanced by IL-1 beta ...
VA-ES-BJ is an epithelioid sarcoma cell line derived in 1991 from a bone marrow metastasis removed from an adult male with primary vertebral epithelioid carcinoma.
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Human bladder cancer specimens. Tumor samples from 109 patients of primary UCC were collected at cystectomy or transurethral resection, and snap frozen in liquid nitrogen. Use of tissues for this study was approved by Cambridgeshire Local Research Ethics Committee (Ref 03/018). A total of 30 sections of 30 μm of fresh frozen tissue were homogenized for DNA and RNA extraction. "Sandwich" H&E sections were prepared for cellularity and grade assessment by a reference urohistopathologist (A.W.). Tumors were staged and graded according to the American Joint Committee on Cancer and WHO/International Society of Urologic Pathology classifications (34, 35). Samples showing tumor cellularity of ,70% and significant inflammatory cell contamination were excluded.. Tissue microarray. For our custom-made tissue microarray (TMA), an independent cohort of 123 formalin-fixed, paraffin-embedded tissue samples of primary UCC was obtained from the pathology archives of Addenbrookes Hospital, Cambridge University ...
Gain of 1q is associated with adverse outcome in favorable histology Wilms tumors. Feb 158 (2): Although several genes/genetic loci involved in the etiolgy of wilms tumor have been identified, little is known of the molecular changes associated with relapse. We therfore undertook an analysis by comparative genomic hybridization (CGH) of 58 tumor samples of favorable histology Wilms tumor taken at inital diagnosis and/or relapse. The results suggest that 1q gain at diagnosis could be used to identify patients with favorable histology Wilms tumor at increased risk of relapse who might benefit from early treatment intensification.. ...
Trilateral retinoblastoma is a syndrome consisting of bilateral (rarely unilateral) hereditary retinoblastoma in association with an intracranial neuroblastic tumour arising usually in the pineal region, infrequently at the suprasellar or parasellar region. It can arise from either hereditary or sporadic forms of retinoblastoma.
PRIMARY OBJECTIVES:. I. To eliminate therapy as the initial approach for infants , 12 months of age with small International Neuroblastoma Risk Group (INRG) stage L1 neuroblastoma while maintaining an overall survival (OS) of 99%.. II. To eliminate therapy as the initial approach for non-high-risk patients , 18 months of age with localized neuroblastoma and favorable biology (histologic and genomic features) while maintaining an OS of 99%.. III. To achieve a 3-year OS of , 81% for infants , 18 months of age with INRG stage Ms neuroblastoma using objective criteria for early initiation of a response-based treatment algorithm.. EXPLORATORY OBJECTIVES:. I. To describe the time to intervention or tumor progression, type of intervention and site of progression for patients with localized neuroblastoma who experience progression after an initial period of observation.. II. To characterize the pharmacokinetic profile of the chemotherapeutic agents carboplatin and etoposide in patients with stage Ms ...
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NBL 3602e Readability With a readability of 10mg, the NBL 3602e is designed to handle most simple weighing tasks within your lab. The NBL 3602e is part of the Adam Equipment
TY - JOUR. T1 - Clear cell primary seminal vesicle carcinoma in a young male-a rare case report. AU - Gaur, Saurabh. AU - Pillai, Sunil B.. AU - Hegde, Padmaraj. AU - Chawla, Arun Kumar. AU - Kapadia, Aseem. PY - 2018/2/1. Y1 - 2018/2/1. N2 - Primary malignancies of Seminal Vesicle (SV) are rare. When involved, it is most commonly due to secondaries or by contiguous spread from adjacent organs. Primary tumours that can arise in SV can be epithelial and mesenchymal. Adenocarcinoma is most common epithelial tumour, and the Clear Cell variant of Adenocarcinoma (CCA) so far has not been reported in literature. Primary SV malignancies like adenocarcinoma pose a diagnostic dilemma as it becomes difficult to differentiate it from secondaries or as involvement from other adjacent organs even with imaging, histopathology and Immunohistochemistry (IHC). Here we present a case of 34-year-old male who presented with occasional total painless haematuria for four years and was evaluated by Contrast Enhanced ...
... , Manmeet Kaur, Sarita Nibhoria, Kanwardeep Tiwana, Akanksha Bajaj, Sahil Ch
We studied N-myc oncogene expression in 13 human neuroectodermal tumors and one teratoma by in situ hybridization. In four of six neuroblastomas, there was increased N-myc expression (15 to 49% of the cells). Many of the primitive neuroblastic cells had an increase of N-myc RNA not observed in the larger, more differentiated cells. Two neuroblastomas matured to ganglioneuromas; no biopsies performed during this progression expressed increased N-myc RNA. Three ganglioneuroblastomas, two tumors presenting as ganglioneuromas, a cerebral neuroectodermal tumor, a neurofibrosarcoma, and the teratoma did not have increased N-myc expression. The data obtained by in situ hybridization correlated well with data obtained by blot analysis. Neuroblastomas/ganglioneuroblastomas with a favorable course did not have appreciable elevation of N-myc expression over 10 to 77 mo of follow-up; thus N-myc may not be involved in the maintenance of the neoplastic state. However, such tumors with a fatal outcome 2 to 14 ...
RATIONALE: Biopsy of sentinel lymph nodes and bone marrow may improve the ability to detect and determine the extent of cancer. PURPOSE: Phase II
Introduction: Gastric cancer is the fifth most commonly diagnosed cancer and the third leading cause of cancer related death worldwide. There are two types of gastric carcinoma: intestinal, characterized by cohesive tumor cells arranged in glandular formation, and diffuse, which is poorly cohesive with crescent-shaped eccentric nuclei. The diffuse type of gastric carcinoma, including signet cell carcinoma, is common in patients less than 50 years of age and is associated with advanced disease and poor prognosis. Diffuse type of carcinoma mostly found in patients without classic risk factors for gastric carcinoma such as untreated H. Pylori, or smoking history. Signet cell carcinoma has a high rate of bone marrow metastasis, and can present with severe cytopenias. Once bone marrow metastasis is diagnosed, average life expectancy is 11 to 121 days. Though the global incidence of gastric carcinoma has declined since 1970, incidence of diffuse-type carcinoma has increased by ten-fold. Case presentation: A
Established from the bone marrow metastasis of a 17-year-old man with undifferentiated (standard classification) or unclassified (Palmer classification) alveolar rhabdomyosarcoma; cells were described as carrying a p53 mutation, expressing high levels of both myogenin and myoD, and expressing the Pax3/FKHR fusion protein secondary to the t(2;13)(q35;q14) ...
• Ganglioneuromas are neuroectodermal tumors that are found in diverse anatomic sites, but they are very uncommon in the colon. We observed a patient with parti
Pedunculated chorangioma is extremely rare type of chorangioma. To the best of our knowledge, no case has been reported in Indian literature. We report one such rare case in a twenty two year old primi gravida who delivered a full term live female baby by lower section caesarian section (LSCS). Gross examination revealed a nodular mass attached to the placenta by a pedicle. Histopathological examination confirmed it as chorangioma. The clinicopathological and radiological feature of this rare entity is presented with a brief review of literature.
Background Urethral metastatic adenocarcinoma is extremely rare. Moreover, only 9 previous cases with metastases from colorectal cancer have been reported to date, and not much information on urethral...
Angiosarcoma arising in a schwannoma is extremely rare with only fourteen cases having been reported in the literature to the best of our knowledge. Amongst these fourteen, only five cases developed from vagal schwannoma. We describe a case of epithe
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
The trifluorosilicon(IV) cation [SiF3(Me3tacn)]+, isolated as salts with [SiF5]-, [B{3,5-(CF3)2C6H3}4]- or Cl-, is obtained by reaction of SiF4 with Me3tacn under anhydrous conditions, and compared with the tetrafluoro complexes [SiF4(tmeda)] and [SiF4{2-Me2N(CH2)2NMe(CH2)2NMe2(CH2Cl)}][SiF5] obtained with the acyclic di- and tri-amines.. Full text not available from this repository.. ...
eng] Stage 4S neuroblastoma (NB) is a special type of NB found in infants with metastases at diagnosis and is associated with an excellent outcome due to its remarkable capacity to undergo spontaneous regression. As genomics have not been able to explain this intriguing clinical presentation, we here aimed at profiling the DNA methylome of stage 4S NB to better understand this phenomenon. To this purpose, differential methylation analyses between International Neuroblastoma Staging System (INSS) stage 4S, stage 4 and stage 1/2 were performed, using methyl-CpG-binding domain (MBD) sequencing data of 14 stage 4S, 14 stage 4, and 13 stage 1/2 primary NB tumors (all MYCN non-amplified in order not to confound results). Stage 4S-specific hyper- and hypomethylated promoters were determined and further characterized for genomic localization and function by cytogenetic band enrichment, gene set enrichment, transcription factor target enrichment and differential RNA expression analyses. We show that ...
Neuroblastoma is an embryonal neoplasm that is predominantly a disease of early childhood. Read Neuroblastomas article to learn all about NBs.
TY - JOUR. T1 - Low-frequency stimulation induces stable transitions in stereotypical activity in cortical networks. AU - Vajda, I.. AU - van Pelt, J.. AU - Wolters, P.. AU - Chiappalone, M. AU - Martinoia, S. AU - van Someren, E.J.W.. AU - van Ooyen, A.. PY - 2008. Y1 - 2008. N2 - Reverberating spontaneous synchronized brain activity is believed to play an important role in neural information processing. Whether and how external stimuli can influence this spontaneous activity is poorly understood. Because periodic synchronized network activity is also prominent in in vitro neuronal cultures, we used cortical cultures grown on multielectrode arrays to examine how spontaneous activity is affected by external stimuli. Spontaneous network activity before and after low-frequency electrical stimulation was quantified in several ways. Our results show that the initially stable pattern of stereotypical spontaneous activity was transformed into another activity pattern that remained stable for at least ...
We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors). Comprehensive analysis of 77 FHWTs indicates that tumors with SIX1/2 and/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are significantly associated with both perilobar nephrogenic rests and 11p15 imprinting aberrations. Significantly decreased expression of mature Let-7a and the miR-200 family (responsible for mesenchymal-to-epithelial transition) in miRNAPG mutant tumors is associated with an undifferentiated blastemal histology. The combination of SIX and miRNAPG mutations in the same tumor is associated with evidence of RAS activation and a higher rate of relapse and death. ...
Successful Treatment with Continuous High-Dose 5-Fluorouracil Infusion, Followed by Oral Capecitabine in a Patient with Advanced Gastric Cancer with Bone Marrow Metastasis and Microangiopathic Hemolytic ...