Poor drug delivery to brain tumors caused by aberrant tumor vasculature and a partly intact blood-brain barrier (BBB) and blood-brain tumor barrier (BTB) can significantly impair the efficacy of chemotherapy. Determining drug delivery to brain tumors is a challenging problem, and the noninvasive detection of drug directly in the tumor can be critically important for accessing, predicting, and eventually improving effectiveness of therapy. In this study, in vivo magnetic resonance spectroscopy (MRS) was used to detect an anticancer agent, temozolomide (TMZ), in vivo in murine xenotransplants of U87MG human brain cancer. Dynamic magnetic resonance imaging (MRI) with the low-molecular-weight contrast agent, gadolinium diethylenetriaminepentaacetic acid (GdDTPA), was used to evaluate tumor vascular parameters. Carbon-13-labeled TMZ ([C-13]TMZ, 99%) was intraperitoneally administered at a dose of similar to 140 mg/kg (450 mg/m(2), well within the maximal clinical dose of 1000 mg/m(2) used in humans) ...
T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA : Purpose Myocardial T1 relaxation time (T1 time) and extracellular volume fraction (ECV) are altered in patients with diffuse myocardial fibrosis. The purpose of this study was to perform an intra-individual assessment of normal T1 time and ECV for two different contrast agents. Methods A modified Look-Locker Inversion Recovery (MOLLI) sequence was acquired at 3 T in 24 healthy subjects (8 men; 28
Cardio-vascular magnetic resonance imaging (CMR) can be used to obtain integrated information on both cardiac function and on advanced tissue characteristics. Using contrast-enhanced techniques, highly diagnostic information on tissue viability, infl
OBJECTIVE. We compared the diagnostic performance of gadoxetic acid-enhanced MRI with that of triple-phase 16-, 40-, and 64-MDCT in the preoperative detection of hepatocellular carcinoma (HCC).. SUBJECTS AND METHODS. Sixty-two consecutively registered patients (54 men, eight women; age range, 31-67 years) with 83 HCCs underwent triple-phase (arterial, portal venous, equilibrium) CT at 16-, 40-, or 64-MDCT and gadoxetic acid-enhanced 3-T MRI. The diagnosis of HCC was established after surgical resection. Three observers independently and randomly reviewed the MR and CT images on a tumor-by-tumor basis. The diagnostic accuracy of these techniques in the detection of HCC was assessed with alternative free response receiver operating characteristic (ROC) analysis. Sensitivity, positive and negative predictive values, and sensitivity according to tumor size were evaluated.. RESULTS. For each observer, the areas under the ROC curve were 0.971, 0.959, and 0.967 for MRI and 0.947, 0.950, and 0.943 for ...
For the standard- versus double-dose clopidogrel comparison, when pooling the two aspirin strata together, there was no difference in the primary endpoint of cardiovascular death, MI, or stroke at 30 days (4.4% for standard-dose vs. 4.2% for double-dose, HR 0.95, 95% CI 0.84-1.07, p = 0.37). There was a significant interaction with performance of PCI (p-interaction = 0.016), with a lower rate of the primary endpoint with double-dose clopidogrel versus standard-dose clopidogrel in the PCI cohort (4.5% vs. 3.9%, HR 0.85, 95% CI 0.74-0.99) and a numerically higher rate of the primary endpoint with double-dose clopidogrel in the no PCI cohort (4.2% vs. 4.9%, HR 1.17, 95% CI 0.95-1.44). There was also no difference overall in the individual components of the composite endpoint of cardiovascular death (2.2% vs. 2.1%, HR 0.96, 95% CI 0.81-1.14, p = 0.63), MI (2.2% vs. 1.9%, HR 0.86, 95% CI 0.73-1.03, p = 0.097), or stroke (0.5% each, p = 0.95) for standard- versus double-dose clopidogrel, respectively. ...
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The porcine model is increasingly being used in neuroscience research as the large brain volume and similarity of cortical and subcortical anatomy to the human brain may offer increased translational relevance over rat and non-human primate models. The aims of this recently published study using convection enhanced delivery (CED) in pig brains were two-fold: (1) To assess the targeting and to determine distribution volumes of MANF in porcine putamen and substantia nigra and (2) to correlate the distribution volumes of MANF with co-infused gadolinium-DTPA.. Using a recessed-step catheter design it was possible to achieve reflux-free infusions in both putamen and substantia nigra. The volumes of distribution of gadolinium-DTPA and MANF were determined by real-time magnetic resonance imaging (MRI) and immunohistochemical analysis, respectively. The authors concluded that the distributions of gadolinium-DTPA and MANF correlated well and that co-infusion of gadolinium as a proxy measure of MANF ...
Gadodiamide is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI. Gadodiamide is used to help diagnose certain disorders of the brain and spine (central nervous...
Each subject will receive HBPM at baseline, week 2, week 6 and week 10 respectively.For baseline HBPM, it was performed in the evening before visit 2 and in the morning of visit 2(before intake of study drug). in terms of the following 3 times of HBPM, they are performed during 5 days before each visit ...
METHODS: In this blinded randomized crossover study, 20 patients with known myocardial infarction underwent two separate delayed-enhancement MRI examinations after receiving 0.1 mmol/kg gadobenate dimeglumine and 0.2 mmol/kg gadopentetate dimeglumine (random administration). The conspicuity of lesion enhancement 5, 10, and 20 minutes after contrast administration was quantified as relative enhancement ratio (RER).. RESULTS: With either gadolinium-based contrast agent, damaged myocardium had higher signal intensity than normal remote myocardium (RER , 4) on delayed-enhancement MR images, and the blood RER declined over time after contrast administration. The blood RER was not significantly higher for gadobenate dimeglumine than for gadopentetate dimeglumine at 5 and 10 minutes. Nevertheless, there was a larger reduction in blood RER for gadobenate dimeglumine than for gadopentetate dimeglumine between 5 and 10 minutes and between 10 and 20 minutes. The volumes of enhancement were similar for ...
TY - JOUR. T1 - Liver perfusion changes occurring during pancreatic islet engraftment. T2 - A dynamic contrast-enhanced magnetic resonance study. AU - Esposito, A.. AU - Palmisano, A.. AU - Maffi, P.. AU - Malosio, M. L.. AU - Nano, R.. AU - Canu, T.. AU - De Cobelli, F.. AU - Piemonti, L.. AU - Ironi, G.. AU - Secchi, A.. AU - Del Maschio, A.. PY - 2014/1. Y1 - 2014/1. N2 - The aim of this study was to investigate liver microvascular adaptation following the intraportal infusion of pancreatic islets (pancreatic islet transplantation [islet-tx]) in diabetic patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DCE-MRI was performed before and 7 days after islet-tx in six diabetic patients. Initial area under curve (AUC60) and volume transfer coefficient (Ktrans) were assessed as markers of liver perfusion. Clinical and metabolic monthly follow-up was performed in all patients, considering fasting C-peptide and β-score as main indices of graft function. High variability ...
How is T1-weighted, gadolinium-enhanced magnetic resonance Imaging abbreviated? T1-MRI stands for T1-weighted, gadolinium-enhanced magnetic resonance Imaging. T1-MRI is defined as T1-weighted, gadolinium-enhanced magnetic resonance Imaging rarely.
TY - GEN. T1 - Segmentation and classification of breast tumor using dynamic contrast-enhanced MR images. AU - Zheng, Yuanjie. AU - Baloch, Sajjad. AU - Englander, Sarah. AU - Schnall, Mitchell D.. AU - Shen, Dinggang. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Accuracy of automatic cancer diagnosis is largely determined by two factors, namely, the precision of tumor segmentation, and the suitability of extracted features for discrimination between malignancy and benignancy. In this paper, we propose a new framework for accurate characterization of tumors in contrast enhanced MR images. First, a new graph cut based segmentation algorithm is developed for refining coarse manual segmentation, which allows precise identification of tumor regions. Second, by considering serial contrast-enhanced images as a single spatio-temporal image, a spatio-temporal model of segmented tumor is constructed to extract Spatio-Temporal Enhancement Patterns (STEPs). STEPs are designed to capture not only dynamic ...
Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.
Heterogeneity is a common finding within tumours. We evaluated the imaging features of tumours based on the decomposition of tumoural dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data to identify their prognostic value for breast cancer survival and to explore their biological importance. Imaging features (n = 14), such as texture, histogram distribution and morphological features, were extracted to determine their associations with recurrence-free survival (RFS) in patients in the training cohort (n = 61) from The Cancer Imaging Archive (TCIA). The prognostic value of the features was evaluated in an independent dataset of 173 patients (i.e. the reproducibility cohort) from the TCIA I-SPY 1 TRIAL dataset. Radiogenomic analysis was performed in an additional cohort, the radiogenomic cohort (n = 87), using DCE-MRI from TCGA-BRCA and corresponding gene expression data from The Cancer Genome Atlas (TCGA). The MRI tumour area was decomposed by convex analysis of mixtures (CAM), resulting
TY - JOUR. T1 - Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging. T2 - Radiological-pathological correlation. AU - Fujiwara, Hiroyasu. AU - Sekine, Shigeki. AU - Onaya, Hiroaki. AU - Shimada, Kazuaki. AU - Mikata, Rintaro. AU - Arai, Yasuaki. PY - 2011/12. Y1 - 2011/12. N2 - We report a case of focal nodular hyperplasia in a patient for whom gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)- enhanced magnetic resonance imaging (MRI) and histological analysis results were available. Dynamic contrast-enhanced computed tomography showed a well-defi ned hypervascular lesion 14 mm in diameter with no visible central scars. Gd-EOB-DTPA-enhanced MRI demonstrated strong peripheral enhancement of the lesion during the hepatobiliary phase, resulting in ring-like enhancement. The pathology examination revealed that the lesion was focal nodular hyperplasia (FNH). Immunohistochemistry showed positive expression ...
Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I ...
Material and method Two intracranial stents (Enterprise and Helistent) were placed in polyvinyl chloride tubes as vascular phantoms. They were filled with six different doses of gadolinium contrast agent (1.0, 2.0, 4.0, 6.0, 8.0, and 10.0 mmol/L dimeglumine gadopentetate, respectively) and imaged using 3 T and 1.5 T MR systems. Relative in-stent signal (RIS) was calculated and artificial luminal narrowing (ALN) was obtained using pixel by pixel analysis. ...
Pretreatment dynamic contrast-enhanced MRI biomarkers correlate with progression-free survival in primary central nervous system lymphoma Academic Article ...
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Diffusely infiltrative form of aggressive intrasegmental recurrence of hepatocellular carcinoma with tumor thrombus formation (HCC) after radiofrequency ablation. (A) Gadoxetic acid-enhanced magnetic resonance image obtained during portal venous phase before RFA shows HCC (asterisk) in the bottom portion of segment VIII. HCC was diagnosed by percutaneous liver biopsy before treatment because arterial hypervascularization was equivocal. The index tumor was in broad contact with a small peritumoral portal vein (arrow). (B) Contrast-enhanced axial computed tomography (CT) scan obtained during portal venous phase 7 months after RFA shows neither local tumor progression around involution of the ablation zone (asterisk) nor intrahepatic distant recurrence. Adjacent portal veins appear patent, with no evidence of tumor thrombus (arrows). (C) CT scan obtained during hepatic arterial phase 24 months after RFA shows an ill-defined enhancing lesion with a diffusely infiltrative pattern (white arrows) in ...
Introduction: First-pass contrast enhanced myocardial perfusion MR imaging in rodents has so far not been possible due to the challenging temporal and spatial resolution requirements.. Hypothesis: New spatio-temporal undersampling schemes such as k-t SENSE permit the acquisition of first pass myocardial perfusion MR data in rodents on a clinical MR scanner and quantitative estimates of myocardial blood flow.. Methods: We developed a new first pass perfusion MR method for rodent imaging on a clinical 3.0 Tesla scanner (Philips Healthcare, Best, the Netherlands) that employed 10-fold k-space and time domain undersampling with constrained image reconstruction using temporal basis sets (k-t PCA) to achieve a spatial resolution of 0.2 × 0.2 × 1.5mm3 and an acquisition window of 43ms. The method was tested in 5 healthy and 4 infarct mice (C57BL/6J).. Results: Data were acquired successfully in all mice at heart rates of 495.1±45.8bpm. Signal-intensity-time profiles showed a percentage myocardial ...
Dynamic contrast-enhanced (DCE)-MRI is useful to assess the early effects of drugs acting on tumor vasculature, namely anti-angiogenic and vascular disrupting agents. Ultra-high-field MRI allows higher-resolution scanning for DCE-MRI while maintaining an adequate signal-to-noise ratio. However, increases in susceptibility effects, combined with decreases in longitudinal relaxivity of gadolinium-based contrast agents (GdCAs), make DCE-MRI more challenging at high field. The aim of this work was to explore the feasibility of using DCE-MRI at 11.7 T to assess the tumor hemodynamics of mice. Three GdCAs possessing different molecular weights (gadoterate: 560 Da, 0.29 mmol Gd/kg; p846: 3.5 kDa, 0.10 mmol Gd/kg; and p792: 6.47 kDa, 0.15 mmol Gd/kg) were compared to see the influence of the molecular weight in the highlight of the biologic effects induced by combretastatin A4 (CA4). Mice bearing transplantable liver tumor (TLT) hepatocarcinoma were divided into two groups (n = 5-6 per group and per ...
A method was devised for obtaining dynamic contrast-enhanced T1-weighted and relaxation rate (delta R2*) images simultaneously to evaluate regional hemodynamics of the brain tumors. On a 1.5-T MR system, dual dynamic contrast-enhanced images were obtained using a gradient echo (dual echo fast field …
title: Gadolinium-Enhanced Magnetic Resonance Imaging of Atherosclerotic Plaques in Comparison with Histopathology: An In Vivo Study in Aorta of Rabbits, doi: none, category: Article
Dynamic Contrast-Enhanced Magnetic is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. The method assists
Purpose To evaluate the feasibility of ultrafast dynamic contrast-enhanced (UF-DCE) magnetic resonance imaging (MRI) with compressed sensing (CS) for the separate identification of breast arteries/veins and perform temporal evaluations of breast arteries and veins with a focus on the association with ipsilateral cancers. Materials and Methods Our Institutional Review Board approved this study with retrospective…
Background: Diffuse myocardial fibrosis (DF) in adults with aortic stenosis (AS) is associated with heart failure, arrhythmias, and mortality; however, little is known about its role in younger patients with congenital AS. Study aims were to apply for the first time a recently validated cardiac magnetic resonance (CMR) extracellular volume fraction (Vec) measurement technique to quantify DF in children and young adults with AS and to explore associations between DF and indices of diastolic function.. Methods: All pts who had a CMR with myocardial T1 measurement, were ,30 yrs, and had congenital AS with a peak Doppler gradient ≥20 mm Hg at any time prior to the CMR were included. The Vec, a measure of DF, was calculated in the mid-LV by measuring T1 values for blood pool and myocardium before and after gadolinium with a modified Look-Locker technique, and adjusting for hematocrit. Vec results were compared to published values in healthy volunteers (n=14).. Results: Thirty-five pts met inclusion ...
Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης. Ιδρυματικό Καταθετήριο Επιστημονικών Εργασιών ΑΠΘ.Τμήμα περιοδικού.Επιστημονικό άρθρο.2016 . Creators: Efthymiadis, Georgios, Karvounis, Charalampos, Gossios, Thomas D., Zegkos, Thomas, Karamitsos, Theodoros, Athyros, Vasileios.Hypertrophic cardiomyopathy, the most common inherited cardiomyopathy is well known to be the leading cause of sudden cardiac death in young people. However, amongst the population of patients, a small subset bears increased risk of sudden cardiac death and would benefit from implantation of a defibrillator, currently recognized utilizing a series of established risk factors. This risk stratification model is hampered by low positive predictive value. Therefore, novel predictors of sudden death are sought. The advent of cardiac magnetic resonance and late gadolinium enhancement has allowed accurate quantification
A total of 20 patients were enrolled in this study; 10 patients (ages 29 to 64 years) who had survived 9.2 ± 25 years after thoracic external beam radiation for lymphoma and 10 control patients (ages 55 to 66 years) recruited from the University colonoscopy center. All patients underwent a MRI study including cine imaging, left ventricular LGE, and high-resolution LGE imaging of the left atrium. The extent of late gadolinium enhancement was calculated as a relative percent of total left atrial wall using a threshold-based algorithm based on pixel intensity distribution. ...
We describe here in a large group of patients qualitative and semiquantitative DCE-MRI parameters that distinguish sMM from normal controls. We also provide evidence that this technique can identify a distinct patient population in NRC that presents with a pathologic DCE-MRI. Referring to this, pathologic findings according to our analysis were defined by a pattern of strongly increased microcirculation (diffuse variant), focal hotspots in the investigated area (focal pattern), or by an amplitude A above the upper limit of normal controls. It has to be mentioned that a diffuse variant pattern cannot be distinguished from a focal pattern affecting the whole vertebra, which may explain in part why those two patterns seem to seem exclusively in the same, namely the symptomatic patient group.. Different patterns of bone marrow involvement of MM in conventional as well as DCE-MRI have been described concordantly by different authors (14, 23, 29, 30). Diffuse distribution of microcirculation was found ...
Gadolinium chelate administration is largely unnecessary for imaging pediatric tumors when performing MRI or combined PET/MR scans, according to a recent study published by the Journal of Nuclear Medicine.. Heike E. Daldrup-Link, MD, PhD, Stanford School of Medicine, and colleagues compared the accuracy of gadolinium chelate-enhanced and unenhanced MR images of 119 pediatric patients. They also compared the accuracy of gadolinium chelate-enhanced and unenhanced 18F-FDG PET/MR images for 36 pediatric patients.. Overall, the researchers found that gadolinium chelate administration made no significant difference in the diagnostic accuracy of MR or 18F-FDG PET/MR images of pediatric tumors. Read more.. ...
CMR adenosine first pass perfusion yields excellent results for the detection of significant coronary artery disease. As in patients after coronary artery bypass grafts (CABG) myocardial perfusion is more complex and additionally the kinetic of a first pass bolus may by altered due to different distances through the bypasses and/or native vessels, this patient group has been excluded from most published studies. Parameters like speed of contrast wash-in (upslope, time to 50% or peak enhancement) and peak enhancement are indirectly used for visual analysis and may be altered post CABG imitating perfusion defects without significant stenosis. In this case, adenosine perfusion would be an inadequate diagnostic test. ...
The goal of this predoctoral fellowship research project is to improve the temporal and spatial resolutions in dynamic contrast-enhanced magnetic resonance imaging of the breast. Specifically, we investigated the use of non-Fourier encoding for collecting the reduced encoding dynamic data sets. The conclusion from our study was that the current wavelet and SVD encoding methods do not achieve the desired goal of exploiting the desirable truncation properties of these basis functions and, at times, can introduce dangerous artifacts. For Fourier-encoded data, the Reduced-encoding Imaging by Generalized-series Reconstruction (RIGR) method was shown to be a better way to extrapolate the unmeasured dynamic data using a priori constraints than Fourier-keyhole. Next, we further optimized the basis functions of the generalized-series (GS) model used by the RIGR algorithm. The Two-reference RIGR (TRIGR) method resulted from suppressing background information in the GS basis functions, enabling them to better
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We read with great interest the article by Jablonowski et al. (1) showing that contrast-enhanced cardiac magnetic resonance (ce-CMR) overestimates infarct size at 6 h post-reperfusion compared with pathology and that infarct imaging timing by ce-CMR is critical. Although this is not an entirely new finding, the careful and meticulous work performed by the authors demonstrates the rapidly changing nature of acute infarction and reperfused myocardial tissue (2). If this experimental work focuses precisely on infarct sizing, the reader is left with several open questions.. On observation of the different figures from this article (Figures 3 and 6), there is a 50% reduction of infarct size by ce-CMR, whereas there is a 26% increase in myocardial salvage and a 30% reduction in extracellular volume by pathology in the infarcted myocardium and adjacent areas between day 0 and day 7. In this rapid series of myocardial tissue changes, it is hard for the reader to understand that the same changes do not ...
To define the time course and mechanism of enhancement of epidural fibrosis after gadolinium-DTPA (Gd-DTPA) injection, we undertook a three-part study in humans and dogs with epidural scar after spine surgery. First, the dynamic in vivo contrast-enhancing properties of epidural scar were assessed by using sequential fast (18-sec) spin-echo sequences after contrast injection. Epidural scar in dogs rapidly enhanced; peak enhancement (101%) was 6 min after injection, with a slower decline toward baseline to 45% after 44 min. Epidural fibrosis in patients followed a similar pattern, with a maximum enhancement of 73% after 5 min. Paraspinal muscle had a lower peak enhancement in both patients (36%) and dogs (22%). Second, vascular injection in two dogs with India ink demonstrated multiple small vessels throughout the epidural scar. Third, light and electron microscopy was performed on epidural scar obtained at reoperation in both patients and dogs. Light microscopy showed multiple small capillaries ...
Are Gadolinium Dye For Mri Contrast Side Effects Putting Your Health at Risk? | Jul 09, 2017 Check these Gadolinium Dye For Mri Contrast side effect reports: A 46-year-old female patient was diagnosed with NA, treated with GADOLINIUM DYE FOR MRI CONTRAST and reported cardio-respiratory arrest,flushing,obstructive airways disorder. Dosage: . Patient was hospitalized.
Purpose Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides an advantage over conventional MRI in that DCE-MRI provides anatomical, physiological, and hemodynamic information about neoplastic lesions. Our aim in this study was to evaluate spinal metastases from hypervascular renal cell carcinoma (RCC) and hypovascular prostate carcinoma (PC) using a T1 DCE-MRI perfusion technique and to assess the sensitivity and specificity of the perfusion parameters obtained. Materials & Methods A total of 40 patients with spinal metastases and either PC or RCC as the primary tumor were studied. DCE perfusion parameters-vascular permeability (Ktrans), plasma volume (Vp), wash-in, and peak-enhancement were measured to assess their potential as discriminators of tumor histology. A Mann-Whitney U test, at a significance level of p≤0.01, was performed to quantify and compare the significances of the perfusion parameters of PC and those of RCC. Results Of the four perfusion parameters ...
As with most medical conditions, the specific symptoms of Gadolinium Toxicity will vary from person to person. Other than what you will read here and in our research papers, there is no published listing of the common symptoms of Gadolinium Toxicity. By means of a symptom survey of 17 people with high urine levels of Gadolinium, we have…
OBJECTIVE: The association of inflammatory cells and neovessels in atherosclerosis is considered a histological hallmark of high-risk active lesions. Therefore, the development and validation of noninvasive imaging techniques that allow for the detection of inflammation and neoangiogenesis in atherosclerosis would be of major clinical interest. Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis. METHODS AND RESULTS: Atherosclerotic plaques were induced in the aorta of 10 rabbits by a combination of 2 endothelial abrasions and 4 months hyperlipidemic diet. Six rabbits underwent MRI during the injection of Gd-DTPA, whereas 4 rabbits were imaged after injection of 18F-FDG with PET. We found a positive correlation between neovessels count in atherosclerotic plaques and (1) Gd-DTPA uptake parameters evaluated by DCE-MRI (r=0
Prostate cancer T1- and T2 -weighted MRIs acquired on a 1.5 T Philips Achieva by combined surface and endorectal coil include dynamic contrast-enhanced images obtained prior to, during and after I.V. administration of 0.1 mmol/kg bodyweight of Gadolinium-DTPA. For scientific inquiries relating to the data-set please contact Drs. C. Carl Jaffe or Nicolas Bloch at [email protected] or [email protected] ...
NSF Develops In People Who Are Exposed To The Gadolinium Agents. A study of patients exposed to gadolinium contrast dyes at the Mayo Clinic.
To compare the sensitivities of dynamic Gadoteridol (Gd)-enhanced magnetic resonance imaging (MRI) and conventional Gd-enhanced spin-echo (SE) T1-weighted imaging (WI) in the detection of decreased perfusion of early epiphyseal ischaemia, and to dete
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How to pronounce gadolinium in English. The definition of gadolinium is: a ductile silvery-white ductile ferromagnetic trivalent metallic element of the rare...
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This list of minerals containing Gadolinium is built from the mindat.org locality database. This is based on the number of localities entered for mineral species and is therefore slanted towards minerals interesting to collectors with less coverage of common rock-forming-minerals so it does not give an undistorted distribution of Gadolinium mineral species. It is more useful when comparing rare species rather than common species ...
Kelm, B M, Müller, N, Menze, B H and Hamprecht, F A (2006). Bayesian Estimation of Smooth Parameter Maps for Dynamic Contrast-Enhanced MR Images with Block-ICM. Proc Computer Vision and Pattern Recognition Workshop (Mathematical Methods in Biomedical Image Analysis). IEEE Computer Society. 96-103 ...