Furazolidone is a nitrofuran antibacterial agent and monoamine oxidase inhibitor (MAOI). It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M. Furazolidone has been used in human and veterinary medicine. It has a broad spectrum of activity being active against Gram positive Clostridium perfringens Corynebacterium pyogenes Streptococci Staphylococci Gram negative Escherichia coli Salmonella dublin Salmonella typhimurium Shigella Protozoa Giardia lamblia Eimeria species Histomonas meleagridis In humans it has been used to treat diarrhoea and enteritis caused by bacteria or protozoan infections. It has been used to treat travelers diarrhoea, cholera and bacteremic salmonellosis. Use in treating Helicobacter pylori infections has also been proposed. Furazolidone is also used for giardiasis (due to Giardia lamblia), though it is not a first line treatment. As a veterinary medicine, furazolidone has been used with some success to treat salmonids ...

Furazolidone - Furazolidone is an antibiotic used for the treatment of certain bacterial infections such as infectious diarrhoea and enteritis.

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Furazolidone(Furoxone) generic is an antibacterial agent, prescribed for giardiasis and cholera. It works by killing the bacteria and protozoa.

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• Furazolidone and quinacrine hydrochloride were compared for efficacy, toxicity, and ease of administration in 45 young children with giardiasis. With the init

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Increasing resistance to clarithromycin and nitroimidazole is the main cause of failure in the Helicobacter pylori eradication. The ideal retreatment regimen remains unclear, especially in developing countries, where the infection presents high prevalence and resistance to antibiotics. The study aimed at determining the efficacy, compliance and adverse effects of a regimen that included furazolidone, levofloxacin and lansoprazole in patients with persistent Helicobacter pylori infection, who had failed to respond to at least one prior eradication treatment regimen. This study included 48 patients with peptic ulcer disease. Helicobacter pylori infection was confirmed by a rapid urease test and histological examination of samples obtained from the antrum and corpus during endoscopy. The eradication therapy consisted of a 7-day twice daily oral administration of lansoprazole 30 mg, furazolidone 200 mg and levofloxacin 250 mg. Therapeutic success was confirmed by a negative rapid urease test, histological

This nitrofuran derivative is an effective alternative agent for the treatment of giardiasis and also exhibits activity against Isospora belli. Since it is the only agent active against Giardia that is available in liquid form, it is often used to treat young children. Furazolidone undergoes reductive activation in Giardia lamblia trophozoites-an event that, unlike the reductive activation of metronidazole, involves an NADH oxidase. The killing effect correlates with the toxicity of reduced products, which damage important cellular components, including DNA. Although furazolidone had been thought to be largely unabsorbed when administered orally, the occurrence of systemic adverse reactions indicates that this is not the case. More than 65% of the drug dose can be recovered from the urine as colored metabolites. Omeprazole reduces the oral bioavailability of furazolidone. Furazolidone is a monoamine oxidase (MAO) inhibitor; thus caution should be used in its concomitant administration with other ...

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Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin ...

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Nitrofurans have been widely used in veterinary practice as antibacterial agents in the treatment of pigs, poultry, fish and shrimp. Bans on nitrofurans were introduced within the EU primarily because of concerns about their carcinogenicity and mutagenicity. Several other non-European countries have also banned all uses of nitrofurans in food producing animals. Tissue residue of Furazolidone is mainly protein bound, therefore the main metabolite 3amino-2-oxazlidinone (AOZ) is proposed as the marker residue.. The Randox Food Diagnostics AOZ ELISA test kit detects AOZ nitrofuran residues in aquaculture and meat samples. ...

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one another but different from strains circulating in Mexico previously. The strains were indistinguishable from the strain that has caused outbreaks in Haiti, the Dominican Republic, and Cuba (1,2). The strain was susceptible to doxycycline, had intermediate susceptibility to ampicillin and chloramphenicol, was less than fully susceptible to ciprofloxacin, and was resistant to furazolidone and trimethoprim-sulfamethoxazole. An investigation failed to identify a common source of infection, additional cases, or any epidemiologic link between the cases. Both patients were treated with a single, 300-mg dose of doxycycline, and their symptoms resolved.. On September 12 and 13, four cases of cholera were identified by the Hidalgo Public Health Laboratory among residents of La Huasteca region, located approximately 75 miles (121 km) east of Mexico City and inhabited mainly by Otomi and Nahuatl speakers. During September 19-December 15, 2013, a total of 175 cases of cholera were confirmed in La ...

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These results are remarkable when you consider that two previous studies using conventional antibiotics, also conducted on Iranian population, resulted in slightly lower rates of eradication. The first which involved the use of 4 drugs (omeprazole, amoxicillin, each administered twice daily for the first five days, followed by omeprazole, clarithromycin and furazolidone, twice daily for the remaining nine days) resulted in eradication in 50.9% of patients. The second study, which used 4 drugs, (omeprazole, clarithromycin, amoxicillin and bismuth twice daily for 14 days) resulted in 49.1% reduction.. The researchers also pointed out that even though their combination of honey and black seed may not eradicate H. pylori in all cases, it has a palliative effect in gastrointestinal symptoms in non-ulcer dyspepsia. This is likely not true for conventional antibiotics which may have a wide range of adverse effects related to the depopulation of beneficial gut bacteria. In fact, we reported on the use ...

[Objective]The research aimed to isolate and identify pathogen from Rana rotten-mouth-diseases,and to study its drug sensitivity and the action with probiotics.[Method]One strain of pathogen was isolated from rotten-mouth-diseases in Rana,and then was proved to be Vibro alginolyticus through API ID 32 GN System.Sensitive tests and antagonism tests were carried out following.[Result]The results of antimicrobial sensitive tests showed that it was resistant to penicillin G,proctaphlin sodium,ampicillin,new mildew element,vancomycin etc.and insenstentive to spore thiophen,ofloxacin,kanamycin etc.,and sensitive to chloramphenicol,sulperazon,cefoperazone sodium,furazolidone etc.The preobiotcs Bacillus subtilis and Clostridium butyricum showed inhibitory action to Vibro alginolyticus.[Conclusion]The preobiotcs such as Bacillus subtilis could be used to prevent the occurrence of rotten-mouth-diseases.

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Animals. Mice were housed and handled according to institutional guidelines complying with Dutch legislation. Animals used were male or lactating female Bcrp1-/- and wild-type mice, all of ,99% FVB genetic background between 9 and 14 weeks of age. Animals were kept in a temperature-controlled environment with a 12-h light/dark cycle and received a standard diet (AM-II; Hope Farms, Woerden, The Netherlands) and acidified water ad libitum.. Chemicals. Nitrofurantoin, furazolidone, and xylazine were from Sigma-Aldrich (St. Louis, MO); [3H]inulin was from Amersham Biosciences UK, Ltd. (Little Chalfont, Buckinghamshire, UK); ketamine (Ketanest-S) was from Parke-Davis (Hoofddorp, The Netherlands); oxytocin (Sintocinon) was from Novartis (Basel, Switzerland); methoxyflurane (Metofane) was from Medical Developments Australia Pty, Ltd. (Springvale, VIC, Australia); and Ko143 was described previously (Allen et al., 2002). All other compounds used were reagent grade.. Cells and Tissue Culture. The ...

Inhibitory effect of commercial antibiotics and bioactive compounds produced by the isolate W3 against vibrios. Most of the antibiotics used could cause inhibition of all tested strains of V. harveyi (Table 1), Hence antibiotics could be used to control V. harveyi infections that affect aquaculture in Thailand. However, some of them such as chloramphenicol, furazolidone, tetracycline and oxonilic acid are now banned for use in aquaculture as previously mentioned. In general, β-lactam antibiotics such as ampicillin are preferred for use by shrimp farmers to treat luminous vibriosis disease since these groups of antibiotics do not cause significant side effects (Teo et al. 2002). Unfortunately, all tested strains in this study were resistant to ampicillin and this result is in agreement with Teo et al. (2002) who reported that many types of β-lactam antibiotics were no longer able to prevent vibriosis. In Thailand sulphamethoxazole is normally used in hatcheries against Vibrio sp.; however, in ...

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Native male turkey poults (n = 120, 49-d-old) were randomly assigned into 4 groups: poults received a basal diet with a daily subcutaneous PQ injection of 5 mg/kg BW for 7 consecutive days (PQ group), an experimental diet containing 1 g/kg PR with a daily subcutaneous PQ injection for 7 days (PR+PQ group), or received the experimental PR diet with a daily subcutaneous injection of 0.5 mL sterile saline for 7 days (PR group); while the control poults received a basal diet with a daily subcutaneous saline injection for 7 consecutive days (C group). The productive performance in the PQ group showed a significant (P , 0.05) reduction in the weight gain (WG) and feed intake (FI), and impaired feed conversion ratio (FCR). Propolis supplementation in the PR+PQ group significantly ameliorated the PQ effects on WG and FCR. Turkey poults of the PQ and PR+PQ groups had a significant augmentation in the blood malondialdehyde (MDA), tumor necrosis factor-α (TNFα), and corticosterone levels, and in ...

Native male turkey poults (n = 120, 49-d-old) were randomly assigned into 4 groups: poults received a basal diet with a daily subcutaneous PQ injection of 5 mg/kg BW for 7 consecutive days (PQ group), an experimental diet containing 1 g/kg PR with a daily subcutaneous PQ injection for 7 days (PR+PQ group), or received the experimental PR diet with a daily subcutaneous injection of 0.5 mL sterile saline for 7 days (PR group); while the control poults received a basal diet with a daily subcutaneous saline injection for 7 consecutive days (C group). The productive performance in the PQ group showed a significant (P , 0.05) reduction in the weight gain (WG) and feed intake (FI), and impaired feed conversion ratio (FCR). Propolis supplementation in the PR+PQ group significantly ameliorated the PQ effects on WG and FCR. Turkey poults of the PQ and PR+PQ groups had a significant augmentation in the blood malondialdehyde (MDA), tumor necrosis factor-α (TNFα), and corticosterone levels, and in ...

Turkey poults less than six months of age may not be imported into Wisconsin unless they originate directly from NPIP-participating hatcheries (or equivalent state status) which hatch no eggs other than turkey eggs.. Started poultry other than turkey poults may be imported if they originate from NPIP-participating hatcheries (or equivalent state status) which hatch no turkey eggs.. Hatcheries shall comply with sanitation practices prescribed by the state of origin. ...

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TY - JOUR. T1 - Effect of nitrofurans on duodenal ulceration induced by cysteamine or indometacin. AU - Ali, B. H.. PY - 1991. Y1 - 1991. N2 - The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days significantly reduced, in a dose-dependent manner, the incidence and extent of cysteamine-induced ulceration. However, oral NF (100 mg/kg) given for 2 consecutive days had no significant effect on duodenal ulceration. The duodenal mucus content of rats was not significantly affected by either FZ or cysteamine treatments. FZ at an oral dose of 100 mg/kg for 2 consecutive days significantly reduced the incidence and extent of indometacin-induced ulceration. Smaller doses of 25 or 50 mg/kg had no significant effects.. AB - The present experiments examined the protective effect of the nitrofuran drugs, ...

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Citation: Moyle, J.R., Del Los Santos, S., Huff, G.R., Huff, W.E., Rath, N.C., Farnell, M., Fanatico, A., Ricke, S.C., Enders, C., Sonnenborn, U., Donoghue, D.J., Donoghue, A.M. 2012. The probiotic Escherichia coli Nissle 1917 enhances early gastrointestinal maturation in young turkey poults. International Journal of Poultry Science. 11(7):445-452. Interpretive Summary: Concerns over the use of antibiotics as growth promoters has led to interest in finding alternative growth promoters such as natural compounds and probiotics. Supplementing feed with probiotics has shown to enhance the gastrointestinal tract (GIT) development of chickens and turkeys. The human probiotic, E. coli Nissle 1917 (EC Nissle) has been shown to stimulate innate immunity in mammals and to increase body weight in poultry. However, the effect of this probiotic on GIT development has not been studied. The objective of this study was to evaluate the effect of EC Nissle in the maturation of the GIT of young turkey poults. For ...

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Interpretive Summary: Corn is the main grain that provides energy to a baby turkey poults diet so that it can grow. However, at the present time corn is very expensive to use in animal diets. Therefore, alternative grain products are being investigated for their ability to provide energy to a growing poults diet. Rye is one such grain to be considered as a feed energy source for a baby poults diet. These experiments show that a rye-based diet is not a good feed ingredient because it causes damage to the baby poults intestine that result in poor growth by the poult. These experiments are important to poultry nutritionists because they show that rye is not a good source of energy for baby poults diets and that different grains need to be tested to see if they will help the growth of baby turkey poults. Technical Abstract: Rye contains high concentrations of non-starch polysaccharides (NSP), leading to reduced digestibility. Since poultry have little or no endogenous enzymes capable of ...

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