I understand that my personal data, entered in the contact form, will be used to answer my request. Detailed information on how this data is used can be found in our Privacy Policy.* ...
It is well documented that there are significant ventilatory changes in respiratory diseases such as cystic fibrosis, asthma and the onset of bronchiolitis obliterans syndrome (BOS) following chronic rejection of lung transplantation. At present, we use measures such as spirometry and lung biopsies to determine the changes of airway function and disease severity. Our aim is to develop a novel technique called the multi breath nitrogen washout (MBNW) which we believe is able to measure the inhomogeneity of ventilation in both the larger airways (conductive region, generation 1 - 16) as well as the smaller airways (acinar region 17 - 23). Our belief is that these measurements are much more subtle than current techniques and will be more sensitive in measuring large and small airway changes in disease. The MBNW can also give us an insight as to which particular zones of the lung are affected in differing respiratory disease. For example, it is believed that BOS begins at the distal portion of the ...
en] INTRODUCTION: Functional residual capacity (FRC) measurement is now available on new ventilators as an automated procedure. We compared FRC, static thoracopulmonary compliance (Crs) and PaO2 evolution in an experimental model of acute respiratory distress syndrome (ARDS) during a reversed, sequential ramp procedure of positive end-expiratory pressure (PEEP) changes to investigate the potential interest of combined FRC and Crs measurement in such a pathologic state. METHODS: ARDS was induced by oleic acid injection in six anesthetised pigs. FRC and Crs were measured, and arterial blood samples were taken after induction of ARDS during a sequential ramp change of PEEP from 20 cm H2O to 0 cm H2O by steps of 5 cm H2O. RESULTS: ARDS was responsible for significant decreases in FRC, Crs and PaO2 values. During ARDS, 20 cm H2O of PEEP was associated with FRC values that increased from 6.2 +/- 1.3 to 19.7 +/- 2.9 ml/kg and a significant improvement in PaO2. The maximal value of Crs was reached at a ...
In sedated and paralyzed children with acute respiratory failure, the compliance of respiratory system and functional residual capacity were significantly reduced compared with healthy subjects. However, no major studies in children with ARDS have investigated the role of different levels of PEEP and tidal volume on the partitioned respiratory mechanic (lung and chest wall), stress (transpulmonary pressure) and strain (inflated volume above the functional residual capacity). The end-expiratory lung volume was measured using a simplified closed circuit helium dilution method. During an inspiratory and expiratory pause, the airway and esophageal pressure were measured. Transpulmonary pressure was computed as the difference between airway and esophageal pressure. Ten intubated sedated paralyzed healthy children and ten children with ARDS underwent a PEEP trial (4 and 12 cmH2O) with a tidal volume of 8, 10 and 12 ml/kgIBW. The two groups were comparable for age and BMI (2.5 [1.0-5.5] vs 3.0 [1.7-7.2] years
FRC increase in group A is statistically significant (W) (step 1: 1,525 ± 360 ml; step 2: 1,937 ± 583 ml, P , 0.05 vs step 1; step 3: 2,592 ± 659 ml, P , 0.05 vs step 2 and P , 0.01 vs step 1) while the FRC increase in group B is not significant (step 1: 1,697 ± 210 ml; step 2: 1,757 ± 367 ml; step 3: 1,982 ± 365 ml); the FRC of group A is statistically higher than the FRC of group B in step 2 (P , 0.05 MW) and in step 3 (P , 0.01 MW). The ratio increase in group A is statistically significant (W) (step 1: 256 ± 133; step 2: 407 ± 187, P , 0.01 vs step 1; step 3: 379 ± 169, P , 0.05 vs step 1) while the ratio increase in group B is not significant (step 1: 194 ± 50; step 2: 253 ± 83; step 3: 276 ± 73); the ratio of group A is statistically higher than the ratio of group B in step 2 (P , 0.01 MW) and in step 3 (P , 0.05 MW). The Cstat increase in both groups is not significant, but in group A Cstat is statistically higher than Cstat of group B in every step (P , 0.05 MW) (step 1: 38 ...
TY - JOUR. T1 - Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation. AU - Sera, Toshihiro. AU - Uesugi, Kentaro. AU - Himeno, Ryutaro. AU - Yagi, Naoto. PY - 2007/6/15. Y1 - 2007/6/15. N2 - Previously, we developed a synchrotron radiation CT system to evaluate the morphometric changes (length and diameter, D) and small airway compliance (sCaw) of euthanized mice under quasi-static inflation [Sera, T., Uesugi, K., Yagi, N., 2005. Localized morphometric deformations of small airways and alveoli in intact mouse lungs under quasi-static inflation. Respir. Physiol. Neurobiol. 147, 51-63). Using this system, this study compared normal and asthmatic small airways. Ovalbumin-treated mice were used as an asthma model. Compared with the values at functional residual capacity, D of normal and asthmatic small airways (D , 200 μm) increased by 48% and 36% at the end of tidal inspiration. For larger airways (D , 500 μm), the increases were 23% and 20%, respectively. ...
Over the last years, ultrasonic equipment for Multiple Breath Washout (MBW) including measurement of functional residual capacity (FRC) and assessment of ventilation inhomogeneity has been developed (EasyOne Pro, ndd Medizintechnik AG, Switzerland). Accuracy of the ultrasonic flow sensor has been demonstrated against mass spectrometry. Validity and feasibility have been demonstrated in single and in multi-centre studies using SF6 as the tracer gas. Recently, the washout procedure has been changed to nitrogen washout. All analysis steps, including delay correction between flow and side-stream molar mass signals were automated to facilitate clinical use.. However, calculation of both, FRC and parameters of ventilation homogeneity depend on accuracy of the underlying algorithms. The aim of the present study was to assess the accuracy of the EasyOnePro software for calculating FRC from nitrogen MBW using a novel lung model.. The lung model consists of an inner and an outer water-filled Plexiglas ...
Ventilation distribution can be assessed by SPECT with Technegas. This study was undertaken in piglets with different degrees of ventilation inhomogeneity to compare PET using Ga-68-labeled pseudogas or "Gallgas" with Technegas. Methods: Twelve piglets were studied in 3 groups: control, lobar obstruction, and diffuse airway obstruction. Two more piglets were assessed for lung volume (functional residual capacity). Results: In controls, SPECT and PET images showed an even distribution of radioactivity. With lobar obstruction, the absence of ventilation of the obstructed lobe was visible with both techniques. In diffuse airway obstruction, SPECT images showed an even distribution of radioactivity, and PET images showed more varied radioactivity over the lung. Conclusion: PET provides detailed ventilation distribution images and a better appreciation of ventilation heterogeneity. Gallgas with PET is a promising new diagnostic tool for the assessment of ventilation distribution.. ...
After securing a 5-year, €90 million ($113.2 million) loan, Swedish CDMO Recipharm is making an investment into expanding its filling capacity at its Monts, France, with a new state-of-the-art filling machine.
Lung volumes in sex-, age-, height-, and weight-matched Black subjects are 10-15% lower than those in Caucasians. To determine whether this decreased lung volume affected the ventilatory adaptation to exercise, minute ventilation (VE), its components, frequency (f) and tidal volume (VT), and breathing pattern were observed during incremental cycle-ergometer exercise. Eighteen Caucasian (age 8-30 yr) and 14 Black (age 8-25 yr) subjects were studied. Vital capacity (VC) was lower (P less than 0.001) in the Black subjects [90.6 +/- 8.6 (SD) vs. 112.9 +/- 9.9% predicted], whereas functional residual capacity/total lung capacity was higher (P less than 0.05). VE, mixed expired O2 and CO2, VT, f, and inspiratory (TI), expiratory (TE), and total respiratory cycle (TT) duration were measured during the last 30 s of each 2-min load. Statistical comparisons with increasing power output were made at rest and from 0.6 to 2.4 W/kg in 0.3-W/kg increments. VE was higher in Blacks at all work loads and reached ...
Objective: To determine the effect of sleeping position on the lung function of prematurely born infants when post term, whether any effect was similar to that before discharge from the neonatal unit, and if it differed according to bronchopulmonary (BPD) status.. Design: Prospective study.. Setting: Tertiary neonatal unit.. Patients: Twenty infants, median gestational age 30 weeks (range 25-32); 10 had BPD.. Interventions: Before neonatal unit discharge (median age 36 weeks postmenstrual age (PMA)) and when post term, infants were studied prone and supine, each position maintained for 3 h.. Main outcome measures: Oxygen saturation was monitored continuously and, at the end of each 3 h period, functional residual capacity (FRC) and compliance (CRS) and resistance (RRS) of the respiratory system were measured.. Results: At a median of 36 weeks PMA and 6 weeks later (post term), respectively, oxygen saturation (98% vs 96%, p = 0.001; 98% vs 97%, p = 0.011), FRC (26 vs 24 ml/kg, p,0.0001; 35 vs 31 ...
A few thoughts. "Flow " and Fi02″ are two different parameters. Due to the concern for the potential adverse effects of oxygen (Fi02), many NICU infants in need of increased respiratory support are weaned to 21% Fi02 with flow. That flow can be delivered via NCPAP, HHFNC, and low flow nasal cannulae. The flow rate itself (PEEP or LPM), has been shown to often help prevent pharyngeal collapse and facilitate maintenance of functional residual capacity (FRC). These two parameters to some extent are likely part of the underpinnings for effective feeding, when WOB and respiratory stability permit PO. However, when an infant is requiring significant Fi02 at baseline, one might question his/her readiness for the aerobic demands of feeding. Depending on the "extra flow" you describe (typically that means for example, PEEP or LPM), it may also create possibly an unsafe feeding environment, as what a conclusion of the recent study by Ferrara et al. See Ferrara, L., et al. "Effect of nasal continuous ...
Background Carbon monoxide diffusion (DLCO) measured with reabreathing (RB) technique and hyperventilation has been found to equal breath holding (BH) measure in healthy adults using homemade device. No assessment of the commercially available RB machine has been performed in sick children in whom BH technique might be difficult to achieve.. Objectives 1) to assess feasibility and repeatability of DLCORB 2) to compare DLCOBH and DLCORB in sick children.. Methods Prospective monocentre study in 46 children with suspicion or actual interstitial disease, able to perform DLCOBH. DLCOBH and RB were measured in duplicate (Masterscreen, Jaeger, Hoechberg, Germany).. Results Correct DLCORB measurements during tidal breathing was obtained in 41 (89%) children (age median 11.8 [8.2 to 18.2]y). Median (IQR) z-score of DCLOAP was -1.94 (-3.30;-1.84)[-9.9 to 1.37].. Functional residual capacity of the two DCLORB measurements was reproducible (within 15%). Alveolar volume (VA) of DLCORB was lower to that of ...
A remaining capacity estimating system and method for an automobile battery capable of estimating and displaying an accurate remaining battery capacity by calculating an internal resistance value of the battery based on a terminal voltage in a disconnected state to electrical loads, a terminal voltage in a selectively connected state to an electrical load and a discharge current value in this connected state, then obtaining a remaining battery capacity at the present temperature condition from a map showing a relationship among a remaining battery capacity, a discharge current and an internal resistance, and finally transforming the obtained remaining battery capacity into a remaining battery capacity at a standard temperature condition.
IITRI now has expanded animal biosafety level 3 (ABSL-3) capacity to conduct pathogen challenge studies for vaccines or therapeutics in non-human primates (NHPs). Our ABSL-3 laboratories include head-only aerosol infection by inhalation exposure and plethysmography capabilities for cynomolgus or rhesus monkeys, African green monkeys, and marmosets.
SAN FRANCISCO (MarketWatch) -- Archer Daniels Midland Co. ADM, +0.62% said Wednesday it plans to convert an existing soybean crushing line at its Europoort facility in the Netherlands to provide multiseed crushing capacity. A soybean crushing line is being converted to rapeseed crushing to supply biodiesel production operations and to meet the needs of existing food oil customers, the Decatur, Ill.-based agricultural processing company said. ADM expects the plant to be operational by January 2007. ...
Pasting the above "text" into MathType 5.0 will enter the above equation and make it possible to edit, save, and use in applications such as MS Word ...
News about Smart Space providing a custom built insulated cold store that they installed in less than one week from enquiry by APS Salads.
When you need a positive displacement pump, diaphragm pumps are an excellent choice. Many sizes, volume and pressure capacities at Ag Spray.
When you need a positive displacement pump, diaphragm pumps are an excellent choice. Many sizes, volume and pressure capacities at Ag Spray.
1. An ideal gas with Cp/Cv=1.5 where Cp and Cv are respectively the heat capacities at constant pressure and constant volume, is used as the working substance of a Carnot engine. The temp of the source is 600K and that of the.
We elucidate unbinding of long semi-flexible bio-polymers from long line-like attractive potential wells (columnar traps). This phase transition has been observed in the experiments with DNA molecules adsorbed on micro-structured supported cationic lipid membranes. It provides a new way to stretch (linearize) single DNA coils [Hochrein, Leierseder, Golubovic, and Raedler, Physical Review E (2007)]. We reveal that this phase transition is an exactly solvable problem of statistical mechanics. Our theory is based on mapping this nontrivial problem onto a novel class of directed random walks. This DNA unbinding transition turns out to have a unique thermodynamic character: It is of the second order however with very weakly (logarithmically) diverging correlation length. This feature induces a very strong divergence of the heat capacity at the unbinding transition of a semi-flexible polymer from a columnar trap. Our exact solution of this statistical physics problem opens a new venue in the theory of ...
Quick question to the pros. If you need 48K BTUs based on a load calculation ( say at 95F outside/75F inside ) design point, do you put in a 4 ton condensor or a 5 ton condensor? My point is a 4 ton condensor probably doesnt produce 4 tons at those design temperatures, it may very well be 3.5 tons. In other words, 4 tons may be a marketing number ( or does does produce 4 tons but not at 95/75 design temperatures). Do you guys look at the actual capacity at your design temps when choosing
Steinmeyer high-performance OEM solutions enable you to bring your customized solutions reliably to market with a customized infrastructure, services and a secure supply chain. Take advantage of all capacities at our location for development, parts manufacturing, micro-assembly, software, testing and certification.. ...
CLEARFIELD, UTAH (Updated Nov. 22, 10:40 a.m. ET) — Lifetime Products Inc. is starting a $41 million project to expand its blow molding capacity at its headquarters in Clearfield, Utah, as Lifetime bought Emotion Kayaks Inc. of Wyomissing, Pa. The company will expand what is currently…
Functional Residual Capacity (FRC) is the volume of air present in the lungs at the end of passive expiration. At FRC, the opposing elastic recoil forces of the lungs and chest wall are in equilibrium and there is no exertion by the diaphragm or other respiratory muscles. FRC is the sum of Expiratory Reserve Volume (ERV) and Residual Volume (RV) and measures approximately 2400 mL in an 80 kg, average-sized male. It cannot be estimated through spirometry, since it includes the residual volume. In order to measure RV precisely, one would need to perform a test such as nitrogen washout, helium dilution or body plethysmography. A lowered or elevated FRC is often an indication of some form of respiratory disease. For instance, in emphysema, FRC is increased, because the lungs are more compliant and the equilibrium between the inward recoil of the lungs and outward recoil of the chest wall is disturbed. As such, patients with emphysema often have noticeably broader chests due to the relatively ...
Several factors contribute to overall gas exchange in the lungs. Each breath (tidal volume) is composed of functional movement of air in and out of the alveolus and nonfunctional movement of air through bronchioles, bronchi, trachea, and nonperfused areas of lung (physiologic dead space). The physiologic dead space is approximately 30% of the tidal volume. The air remaining in the chest at the end of exhalation is referred to as the functional residual capacity. Dead space and the functional residual capacity do not contribute to gas exchange. The amount of air inhaled and exhaled in a minute is referred to as minute ventilation and is the product of the respiratory rate and tidal volume. Relatively small changes in the functional alveolar space demand large increases in the minute ventilation to maintain the same rate of gas exchange. Either raising the fraction of inspired oxygen (Fio2) or increasing the surface area or functional residual capacity of the lung can increase total alveolar ...
Answer: A. Functional residual capacity. Pre-oxygenation is the administration of oxygen to a patient prior to intubation. It helps to extend the safe apnoea time. The safe apnoea time is defined as the duration of time following cessation of breathing/ventilation that elapses until arterial desaturation occurs (SaO2 reaches , 90%). The primary mechanism by which pre-oxygenation works is by denitrogenation of the lungs, however maximal pre-oxygenation is achieved when the alveolar, arterial, venous and tissue compartments are all filled with oxygen. Denitrogenation is achieved using oxygen to wash out the nitrogen contained in the lungs after breathing room air, resulting in a larger alveolar oxygen reservoir.. The functional residual capacity (FRC) is the volume of gas that remains in the lungs after a normal tidal expiration. It is the sum of the residual volume (RV) and the expiratory reserve volume (ERV). One method of measuring the FRC is the nitrogen washout technique.. The FRC is ...
BACKGROUND: Pulmonary chronic graft-vs-host disease (cGvHD) after hematopoietic stem cell transplantation (HSCT) is characterized by impairment of the small airways. Assessment of lung clearance index (LCI) gained from multiple breath washout (MBW) is more sensitive than spirometry in detection of small airways disease. The aim of this study was to describe the development of LCI during the first year after pediatric HSCT and how LCI relates to other pulmonary function parameters and cGvHD.. METHODS: This prospective, longitudinal study included 28 pediatric HSCT-recipients. Spirometry, Sulfur hexafluoride MBW and diffusion capacity of the lungs were performed before and at 3, 6, 9, and 12 months after HSCT. Respiratory symptoms and signs of cGvHD were recorded at each visit.. RESULTS: Before HSCT, 47.8% had abnormal LCI and 12.5% had abnormal forced expiratory volume in 1 second (FEV1 ). Patients with persisting respiratory symptoms 12 months post-HSCT had higher median LCI (factor 5.7, P = ...
Pulmonary hyperinflation is commonly divided into static and dynamic in patients with chronic obstructive pulmonary disease (COPD). The former can be directly attributed to the emphysema-related reduction in lung elasticity, leading to a larger volume at which lung and chest wall recoil pressures are balanced. As a consequence, both total lung capacity and functional residual capacity increase above their normal levels. Conversely, dynamic hyperinflation (DH) is caused by expiratory airflow limitation, air trapping and "auto-positive end-expiratory pressure". This further increases functional residual capacity.. Extensive literature has accumulated on the objective and subjective manifestations and sequelae of pulmonary hyperinflation in COPD, including effects on respiratory muscle function, ventilation, work of breathing, exercise tolerance, cardiovascular function, dyspnoea and health status. The purpose of the articles in this issue of the European Respiratory Review is to summarise some of ...
In a pig model of intra-abdominal hypertension, PEEP up to 15 cmH2O did not prevent the FRC decline caused by intra-abdominal hypertension and was associated with reduced oxygen delivery as a consequence of reduced cardiac output. This implies that PEEP levels inferior to the corresponding intra-abd …
In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease. ...
Background: Lung clearance index (LCI) is a sensitive marker of early lung disease in children, but has not been assessed in adults. Measurement is hindered by the complexity of the equipment required. The aims of this study were to assess performance of a novel gas analyser (InnocorTM), and to use it as a clinical tool for the measurement of LCI in cystic fibrosis (CF). Methods: LCI was measured in 48 healthy adults, 12 healthy school-age children, and 33 adults with CF, by performing an inert gas washout from 0.2% sulphur hexafluoride (SF6). SF6 signal:noise ratio and 10-90% rise time of Innocor were compared to a mass spectrometer used in similar studies in children. Results: Compared to the mass spectrometer, Innocor has a superior signal:noise ratio, but a slower rise time (150 ms v 60 ms) which may limit its use in very young children. Mean (SD) LCI in healthy adults was significantly different from that in CF patients: 6.7 (0.4) v 13.1 (3.8), p,0.0001. Ten of the CF patients had ...
Investigators at the University of Otago in New Zealand compared the effects of cannabis and tobacco smoke on lung function in over 1,000 adults.. Researchers reported, "Cumulative cannabis use was associated with higher forced vital capacity [the volume of air that can forcibly be blown out after full inspiration], total lung capacity, functional residual capacity [the volume of air present in the lungs at the end of passive expiration], and residual volume. Cannabis was also associated with higher airways resistance but not with forced expiratory volume in 1 second [the maximum volume of air that can be forcibly blown out in the first second during the FVC test], forced expiratory ratio, or transfer factor. These findings were similar amongst those who did not smoke tobacco.". Authors further reported, "By contrast, tobacco use was associated with lower forced expiratory volume in 1 second, lower forced expiratory ratio, lower transfer factor, and higher static lung volumes, but not with ...
East Rutherford, NJ - November 8, 2017 - Cambrex Corporation (NYSE: CBM), the leading manufacturer of small molecule innovator and generic Active Pharmaceutical Ingredients (APIs), today announced that it has completed an expansion of cGMP small scale capacity at its Charles City, Iowa plant.. The project has seen the installation of two 500 gallon glass lined reactors and creates a third small scale work center, further increasing flexibility for customer projects.. "Small scale manufacturing has been identified as being a crucial area where capacity is at a premium within the industry, and this investment has been undertaken to increase our flexibility and reduce potential project bottle necks to benefit our customers," commented Joe Nettleton, Vice President US Operations, Cambrex. "This continues Cambrexs ongoing commitment to investing in small molecule manufacturing, ensuring that we can meet the challenges of customer project timelines, especially at the key development stages.". This ...
V/Q mismatch-The most common etiology for hypoxemia is V/Q mismatch. Dead space is ventilation without perfusion, as seen with pulmonary embolism. Shunt is perfusion without ventilation, as seen with pneumothorax. Hypoxic pulmonary vasoconstriction improves V/Q matching by reducing shunt as poorly oxygenated areas of the lung vasoconstrict, diverting blood to more oxygenated regions.. Functional residual capacity (FRC) is the volume remaining in the lung after normal exhalation. Closing capacity (CC) is the lung volume at which small airways without cartilaginous support close. If CC exceeds FRC, atelectasis occurs. Atelectasis commonly occurs in the postoperative period during anesthetic recovery as a result of inadequate tidal volumes. Pneumonia and bronchospasm can also cause V/Q mismatch in the perioperative setting. ...
As measured by centralized, standardized computer tomographic (CT) lung densitometry. CT scans were acquired at 2 inspiration states: TLC (Total Lung Capacity; ie, full inspiration) and FRC (Functional Residual Capacity; ie, full expiration). Results were adjusted for total lung volume and are presented as point estimates for the average rate of decline in the early start and delayed start subgroups from a linear random regression model with country, inspiration state (only for TLC and FRC state), time (time elapsed since Day 1 [CE1226_4001]), treatment and treatment by time interaction as fixed effects and subject and subject by time interaction as random coefficients ...
The closing capacity (CC) is the volume in the lungs at which its smallest airways, the respiratory bronchioles, collapse. The alveoli lack supporting cartilage and so depend on other factors to keep them open. The closing capacity is greater than the residual volume (RV), the amount of gas that normally remains in the lungs during respiration, and specifically, after forced expiration. This is because closing capacity is equal to closing volume plus residual volume. This means that there is normally enough air within the lungs to keep these airways open throughout both inhalation and exhalation. As the lungs age, there is a gradual increase in the closing capacity (i.e. The small airways begin to collapse at a higher volume/before expiration is complete). This also occurs with certain disease processes, such as asthma, chronic obstructive pulmonary disease, and pulmonary edema. Any process that increases the CC by increasing the functional residual capacity (FRC) can increase an individuals ...
Due to a higher metabolic rate, oxygen consumption is increased in children, especially in infants. Infants and children have an increased relative cardiac output and minute ventilation to match the increased metabolic demand. However, children are vulnerable to rapid desaturation when oxygenation or ventilation is reduced. Children have relatively small-volume lungs with small functional residual capacities. This translates into a reduced oxygen reservoir, which decreases the effectiveness of preoxygenation and makes optimal preoxygenation more difficult. Therefore, be prepared to support oxygenation with bag-mask ventilation, often before an intubation attempt, while awaiting the onset of induction and paralysis. Attempts at intubation may need to stop once oxygen saturation drops below 90% to allow for bag-mask ventilation before the next attempt. Below an oxygen saturation of 90%, desaturation is particularly rapid.5 The vast majority of children are easily bag ventilated when the proper ...
The unique ability of the ambient gated venturi within the Phasitron® to hold a precise selectable peak pressure limit, during oscillatory equilibrium, allows the lungs to be held in a scheduled post inspiratory percussive apneustic plateau (for increasing intrapulmonary diffusion), before returning to the programmed baseline. Therefore, a mechanical post inspiratory percussive plateau creates a dynamic functional residual capacity (DIFRC), which can be held for a scheduled interval. 61. The concept of traditional time cycled inspiratory flowrate acceleration can be programmed during VDR® scheduling, to allow the lung with low compliance time to conform to a progressive step inflation (to the higher mandated pressures), while reducing tendencies toward barotrauma. The technique is non-invasive and does not measure CBF directly, but measures CBF velocity. One must assume a constant vessel diameter if the device is used to measure CBF trends. Other derived measurements such as the pulsatility ...
A charity that sponsors a country retreat for wounded warriors and their families is doubling its capacity by building a second house with a donation from a…
Indiana Public Media is your source for news and information, music, arts and community events from WFIU Public Radio and WTIU Public Television
Based on serial lung function measurements performed in 142 children (68 males; 74 females) with cystic fibrosis (CF), prospectively evaluated over an age range of 6 to 20 years, we attempted to determine whether the lung clearance index (LCI) as a measure of ventilation inhomogeneities could be a d …
Selective Catalytic Reduction (SCR) catalysts are used to reduce NOx emissions from internal combustion engines in a variety of applications [1,2,3,4]. Southwest Research Institute (SwRI) performed an Internal Research & Development project to study SCR catalyst thermal deactivation. The study included a V/W/TiO2 formulation, a Cu-zeolite formulation and a Fe-zeolite formulation. This work describes NH3 storage capacity measurement data as a function of aging time and temperature. Addressing one objective of the work, these data can be used in model-based control algorithms to calculate the current NH3 storage capacity of an SCR catalyst operating in the field, based on time and temperature history. The model-based control then uses the calculated value for effective DEF control and prevention of excessive NH3 slip. Addressing a second objective of the work, accelerated thermal aging of SCR catalysts may be achieved by elevating temperatures above normal operating temperatures ...
The method presented here is a field method that may be used to determine mass and volume flow rates in ducts where flow conditions ...
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
Avoidance of hypoxemia is the primary goal, and while there are no evidence-based recommendations regarding the lower limit of acceptable SpO2, most practitioners try to maintain 90% or higher (PaO2 60 mm Hg), adjusting as needed based on other comorbidities. The incidence of hypoxemia during OLV has fallen from 20% from the 1950s to 1980s, to 10% in the 1990s [Hurford WE et al. J Cardiothorac Vasc Anesth 7: 517, 1993], to 1% most recently [Brodsky J and Lemmens HJ. J Cardiothorac Vasc Anesth 17: 289, 2003] Critical to avoiding hypoxemia is an understanding of the basic goal of physiologic management in OLV - maximizing PVR in the operative lung, and minimizing PVR in the dependent lung. Of note, PVR is generally lowest at FRC, and increases hyperbolically as volumes deviate in either direction from FRC. During OLV, FRC occurs at slightly lower-than-normal volumes due to paralysis, lateral positioning, the open operative hemithorax, and the weight of mediastinal structures. Immediately after ...
The Bachem Group (SWX: BANB) announced today that it has opened its new production unit at its US subsidiary Bachem California Inc. in Torrance, California. The expansion offers a forty percent increase in production capacity at the current facility for peptide-based active pharmaceutical ingredients (APIs) to meet increasing market demand in North America. The additional unit, representing an investment of about USD 10 million (CHF 12.5 million), fulfills all FDA requirements for cGMP production. ,media 1208 _blank external-link-new-window,Press Release,/media,. ...
This guideline covers decision-making in people 16 years and over who may lack capacity now or in the future. It aims to help health and social care practitioners support people to make their own decisions where they have the capacity to do so. It also helps practitioners to keep people who lack capacity at the centre of the decision-making process. ...
Three things to cover here. The first is that the nitrate component of spinach will help your muscles work better with the same levels of oxygen. Studies like this one show that just 3 days of spinach eating had a measurable effect. Keep in mind that there are plenty of other foods which are high in nitrates, so this one is not a spinach exclusive.. For me the mix of vitamins and minerals make an indirect difference. With the right balanced diet youll have healthy blood, bones and muscles. Youll be less fatigued after exercise, and generally feel great. That extra iron can keep your haemoglobin levels high too, giving you extra oxygen carrying capacity at the times you need it most.. The foods you are not eating are just as important as what you do eat! When you are focusing on a healthy balanced diet, you will not be eating low GI carbs, sugary foods or processed foods. After just a couple of weeks of clean eating, the foods designed to temp you will start to look and taste awful!. ...