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Sublingual (abbreviated SL), from the Latin for "under the tongue", refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue. Many drugs are designed for sublingual administration, including cardiovascular drugs, steroids, barbiturates, benzodiazepines, opioid analgesics, enzymes and, increasingly, vitamins and minerals. When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first-pass metabolism" in the liver before entering the general circulation. Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster,[quantify] and it ensures that the substance will risk degradation only by salivary enzymes before ...
TY - JOUR. T1 - Predictors of uterine evacuation following early medical abortion with mifepristone and misoprostol. AU - Reeves, Matthew F.. AU - Monmaney, Jessica A.. AU - Creinin, Mitchell D. PY - 2016/2/1. Y1 - 2016/2/1. N2 - Objectives We sought to determine predictors of uterine evacuation for women undergoing medical abortion using mifepristone and vaginal misoprostol through 63 days' gestation. Study Design We pooled data from two prospective multicenter medical abortion trials. In one study, women received mifepristone 200 mg followed either 6-8 or 23-25 h later by misoprostol 800 mcg vaginally. In the second study, women received mifepristone 200 mg followed either ,15 min or 23-25 h later by misoprostol 800 mcg vaginally. We examined the absolute risk (AR) of uterine evacuation using Fisher's Exact Tests for categorical variables and Student t test and Wilcoxon rank-sum tests for continuous variables. We used logistic regression to calculate odds ratios (ORs) of uterine evacuation. ...
Objective: To compare the efficacy of sublingual misoprostol and intravenous syntometrine in the active management of the third stage of labour. Study Design: It was an interventional, quasi experimental. Setting: Obstetrics and Gynecology department of Allied Hospital\Punjab Medical College, Faisalabad Duration: From 1st Nov, 2007 to 30th April 2008. Methods: 100 women were selected and randomly divided into two groups, group A (odd number) and group B (even number) by using random numbers table.600 micrograms sublingual misoprostol was given to Group A and 1 ml of intravenous syntometrine (1ml=5 IU syntocinon and 0.5 mg ergometrine) was given to Group B at the delivery of anterior shoulder of the baby. Results: As regards the efficacy of sublingual misoprostol and I.V. syntometrine, the amount of mean blood loss and use of additional uterotonics, results were not statistically significant. None of the patients required manual removal of placenta and there was no case of prolonged third stage ...
TY - JOUR. T1 - Oral mifepristone and buccal misoprostol administered simultaneously for abortion. T2 - a pilot study. AU - Lohr, Patricia A.. AU - Reeves, Matthew F.. AU - Hayes, Jennifer L.. AU - Harwood, Bryna. AU - Creinin, Mitchell D. PY - 2007/9. Y1 - 2007/9. N2 - Background: Simultaneous oral mifepristone and vaginal misoprostol has a 24-h expulsion rate of approximately 90% when used for abortion through 63 days' gestation. This pilot study sought to determine if a simultaneous regimen using buccal misoprostol would be similarly effective and merit further investigation. Study design: One hundred twenty women were enrolled into three equal groups by gestational age: ≤49 days (Group 1), 50-56 days (Group 2) and 57-63 days (Group 3). After swallowing 200 mg of mifepristone, subjects received 800 mcg buccal misoprostol. Participants returned in 24±1 h for evaluation of expulsion by ultrasonography. Women with a persistent gestational sac received 800 mcg vaginal misoprostol. Further ...
Home abortion The abortion pill causes cramping and bleeding that can last several hours or more. You can be at home, or whatever is comfortable for you. Plan on taking it easy for the day. Abortion Clinics I, Legal Abortion Clinics, Safe Abortion Pills For Sale, Cheap Abortion Clinics, Women's Clinics, Termination Pills For Sale, Abortion Clinics Around, Medical Abortion Clinics, How Much Is Abortion Pills, Where Can I Get Abortion Pills, Abortion Clinics Near Me. Where Can I Get The Abortion Pill & How Much Will It Cost?. Abortion Clinics Best and safest way a woman can do an abortion herself until the 28th weeks of pregnancy is with the use of two medicines called Mifepristone (also known as the abortion pill, RU486, Mifegyne, Mifeprex), and Misoprostol (also known as Cytotec, Arthrotec, Oxaprost, Cyprostol, Mibetec, Prostokos or Misotrol). If you live in a country where there is no access to safe abortion services and you would like to obtain a medical abortion with Mifepristone and ...
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The objective of this study was to determine if pregnant, literate women and female community health volunteers (FCHVs) in Nepal can accurately determine a woman's eligibility for medical abortion using a toolkit, compared to comprehensive-abortion-care-trained providers.. Women presenting for first-trimester abortion, and FCHVs, independently assessed each woman's eligibility for medical abortion using a modified gestational dating wheel to determine gestational age and a nine-point checklist of medical abortion contraindications or cautions. Ability to determine eligibility was then compared to experienced CAC-providers using Nepali standard of care. Both women and FCHVs accurately interpreted the wheel 96% of the time, and the eligibility checklist 72% and 95% of the time, respectively. Further refinement of the eligibility tools, particularly the checklist, is needed before their widespread use ...
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Sublingual misoprostol produces rapid peak concentration and is more effective than oral misoprostol for prevention of excessive postpartum bleeding. The study hypothesis was to test whether women receiving sublingual misoprostol for prevention of postpartum hemorrhage have 30 ml less average blood loss than women receiving oxytocin, the standard of care for prevention of postpartum hemorrhage. We conducted a Double blind randomized controlled trial of .652 consenting, eligible pregnant women admitted to the labor room of the teaching hospital at J N Medical College, Belgaum, India. Women participating in the study were assigned by computer generated randomization to receive the study medications and placebos within one minute after clamping and cutting the umbilical cord. We also looked at the drugs effects on postpartum blood loss at or above ≥500 ml (considered hemorrhage), and the percent of women experiencing more than a 10% decline in haemoglobin, and reported drug side effects ...
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OBJECTIVE: To study the effects of early versus delayed oxytocin augmentation on the obstetrical and neonatal outcome in nulliparous women with spontaneous but prolonged labour. DESIGN: Randomised controlled study. SETTING: Two delivery units in Sweden. POPULATION: Healthy nulliparous women with normal pregnancies, spontaneous onset of active labour, a cervical dilatation of 4-9 cm and no progress in cervical dilatation for 2 hours and for an additional hour if amniotomy was performed due to slow progress. METHODS: Women (n = 630) were randomly allocated either to labour augmentation by oxytocin infusion (early oxytocin group) or to postponement of oxytocin augmentation for another 3 hours (expectant group). MAIN OUTCOME MEASURE: Mode of delivery (spontaneous vaginal or instrumental vaginal delivery or caesarean section) and time from randomisation to delivery. RESULTS: The caesarean section rate was 29 of 314 (9%) in the early oxytocin group and 34 of 316 (11%) in the expectant group (OR 0.8, 95% CI 0
Objective: The objective of this selective EBM review is to determine whether or not methylergometrine is more effective than other uterotonic agents in preventing postpartum hemorrhage during the third stage of labor. Study Design: Review of two randomized controlled trials (RCTs) published in 2004 and 2009, and one prospective study published in 2006. Data Sources: Each article used was published in English and found using PubMed and Medline. The studies compared the efficacy of methylergometrine against uterotonic agents, specifically oxytocin and misoprostol. Outcomes Measured: The efficacy of methylergometrine was measured via the incidence of postpartum hemorrhage despite the use of prophylactic medication and adverse effects of medications. Results: Vimala et al (2004) found that methylergometrine and misoprostol were equally effective at decreasing the amount of blood loss [170±42ml vs. 185±56ml; p |0.05], as well as in terms of adverse side effects, specifically nausea [13.3% vs. 6.6%; p |0
Cytotec Misoprostol PE Jaboatão dos Guararapes, Cytotec Misoprostol PE Olinda, Cytotec Misoprostol PE Paulista, Cytotec Misoprostol PE Petrolina, Cytotec Misoprostol PE Recife, Cytotec Misoprostol PI Parnaíba, Cytotec Misoprostol PI Teresina, Cytotec Misoprostol PR Cascavel, Cytotec Misoprostol PR Colombo, Cytotec Misoprostol PR Curitiba, Cytotec Misoprostol PR Foz do Iguaçu, Cytotec Misoprostol PR Guarapuava, Cytotec Misoprostol PR Londrina, Cytotec Misoprostol PR Maringá, Cytotec Misoprostol PR Paranaguá, Cytotec Misoprostol PR Ponta Grossa, Cytotec Misoprostol PR São José dos Pinhais, Cytotec Misoprostol RJ Angra dos Reis, Cytotec Misoprostol RJ Barra Mansa, Cytotec Misoprostol RJ Belford Roxo, Cytotec Misoprostol RJ Cabo Frio, Cytotec Misoprostol RJ Campos dos Goytacazes, Cytotec Misoprostol RJ Duque de Caxias, Cytotec Misoprostol RJ Itaboraí, Cytotec Misoprostol RJ Macaé, Cytotec Misoprostol RJ Magé, Cytotec Misoprostol RJ Maricá, Cytotec Misoprostol RJ Mesquita, Cytotec ...
TY - JOUR. T1 - Current medical abortion care. AU - Creinin, Mitchell D. PY - 2003/12. Y1 - 2003/12. N2 - Medical abortion using mifepristone and a prostaglandin analogue is a highly effective option for early abortion. Since the clinical introduction of mifepristone to the world in 1988, millions of women have had the opportunity to have a safe abortion without primary surgical intervention. The standard method of providing medical abortion has evolved through well-done studies to develop regimens that decrease cost and time to abortion. Currently, mifepristone with misoprostol is the most widely used medical abortion regimen. The most effective option available involves mifepristone 200 mg followed at least 24 hours later by misoprostol 800 μg vaginally. Women can self-administer the misoprostol, with complete abortion rates exceeding 95%. Researchers continue to refine the available regimens to improve outcomes and acceptability.. AB - Medical abortion using mifepristone and a prostaglandin ...
Risk Summary There are no adequate and well-controlled studies of buprenorphine sublingual tablets or buprenorphine in pregnant women. Limited published data on use of buprenorphine, the active ingredient in buprenorphine sublingual tablets, in pregnancy, have not shown an increased risk of major malformations. Reproductive and developmental studies in rats and rabbits identified adverse events at clinically relevant and higher doses. Embryofetal death was observed in both rats and rabbits administered buprenorphine during the period of organogenesis at doses approximately 6 and 0.3 times, respectively, the human sublingual dose of 16 mg/day of buprenorphine. Pre-and postnatal development studies in rats demonstrated increased neonatal deaths at 0.3 times and above and dystocia at approximately 3 times the human sublingual dose of 16 mg/day of buprenorphine. No clear teratogenic effects were seen when buprenorphine was administered during organogenesis with a range of doses equivalent to or ...
Cesarean scar pregnancy treated by curettage and aspiration guided by laparoscopy Shan-rong Shu, Xin Luo, Zhi-xin Wang, Yu-hong Yao Department of Obstetrics and Gynecology, The First Affiliated Hospital of JiNan University, HuangPu Road West, Guangzhou, People's Republic of China Abstract: Pregnancy in a cesarean scar is the rarest form of an ectopic pregnancy. The treatment for cesarean scar pregnancy mainly includes systemic methotrexate and uterine artery embolization. Here, we reported a case of cesarean scar pregnancy treated by curettage and aspiration guided by laparoscopy. The treatment plan included two phases. Three days after a combination of methotrexate and mifepristone was administered, the gestational sac was removed under laparoscopy, which enabled a successful treatment for the unruptured ectopic pregnancy in a previous cesarean scar and made it possible to preserve the reproductive capability of the patient. Keywords: cesarean scar pregnancy, laparoscopy, curettage and aspiration
Looking for online definition of Machine vacuum aspiration in the Medical Dictionary? Machine vacuum aspiration explanation free. What is Machine vacuum aspiration? Meaning of Machine vacuum aspiration medical term. What does Machine vacuum aspiration mean?
TY - JOUR. T1 - Coagulation parameters during the course of severe postpartum hemorrhage. T2 - A nationwide retrospective cohort study. AU - Gillissen, Ada. AU - Van Den Akker, Thomas. AU - Caram-Deelder, Camila. AU - Henriquez, Dacia D.C.A.. AU - Bloemenkamp, Kitty W.M.. AU - De Maat, Moniek P.M.. AU - Van Roosmalen, Jos J.M.. AU - Zwart, Joost J.. AU - Eikenboom, Jeroen. AU - Van Der Bom, Johanna G.. PY - 2018/10/9. Y1 - 2018/10/9. N2 - We describe the pattern of change in coagulation parameters during the course of severe postpartum hemorrhage in a retrospective cohort study among 1312 women experiencing severe postpartum hemorrhage necessitating blood transfusion. Levels of hemoglobin, hematocrit, platelet count, fibrinogen, activated partial thromboplastin time (aPTT) and prothrombin time (PT) per categorized volume of blood loss during severe postpartum hemorrhage were described and compared between women with and without the composite adverse outcome. Need for surgical intervention, ...
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Early pregnancy termination: a comparison between vacuum aspiration and medical abortion using prostaglandin (16,16 dimethyl-trans-delta 2-PGE1 methyl ester) or
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Misoprostol for the prevention of postpartum hemorrhage during home births in rural Lao PDR: establishing a pilot program for community distribution Jo Durham,1 Alongkone Phengsavanh,2 Vanphanom Sychareun,2 Isaac Hose,1 Viengnakhone Vongxay,2 Douangphachanh Xaysomphou,2 Keith Rickart3 1Faculty of Medicine, School of Public Health, University of Queensland, Brisbane, Queensland, Australia; 2Faculty of Post-Graduate Studies, University of Health Sciences, Vientiane, Lao PDR; 3Communicable Diseases Branch, Department of Health, Brisbane, Queensland, Australia Purpose: The purpose of this study was to gather the necessary data to support the design and implementation of a pilot program for women who are unable to deliver in a healthcare facility in the Lao People’s Democratic Republic (PDR), by using community distribution of misoprostol to prevent postpartum hemorrhage (PPH). The study builds on an earlier research that demonstrated both support and need for community-based distribution of
misoprostol 200 mcg italy. Usage of misoprostol: MISOPROSTOL Misoprostol, sold under the brandname Cytotec among others, is a medication used to start labor, cause an abortion, prevent and treat where can i get mifepristone and misoprostol pills abortion with mifepristone and misoprostol stomach ulcers, and treat postpartum bleeding due to poor contraction of the uterus . Do NOT use ,font color="#0033CC" size="5″,misoprostol,/font, misoprostol if: . It may also is misoprostol taken orally misoprostol how much how to take misoprostol how do i take misoprostol be used for other conditions as determined by your doctor . Product Description: Misoprostol is used ,font color="#0033CC" size="5″,misoprostol,/font, for: Reducing the risk of stomach ulcers in certain patients who take nonsteroidal anti-inflammatory drugs (NSAIDs) . It works by reducing the misoprostol amount of acid released by the stomach and protecting the stomach lining, which helps to reduce the risk of stomach ulcers . use of ...
Background & aim: Recently, the use of mifepristone followed by misoprostol after 36-48 h has been demonstrated to be an effective and safe method for the second trimester medical abortion. However, this regimen entails long total abortion time, and consequently increases the financial burden and anxiety in the patients. We hypothesize that one day interval would be also effective and can be used to provide the abortion care. Regarding this, the present study aimed to compare the effectiveness and safety of 24- and 36-hour intervals between the administration of mifepristone and misoprstol for second trimester abortion. Methods: This prospective comparative study was conducted on 70 females who opted for second trimester medical abortion between 12-20 weeks. Mifepristone (200 mg) was followed by sublingual misoprostol (800 mcg) after one and two days in the first and second groups, respectively. Four hours after the administration of 800 mcg misoprostol, all patients received 400 mcg sublingual
TY - JOUR. T1 - Use of sublingual buprenorphine for pain relief in office hysteroscopy. AU - Lin, Yu Hung. AU - Hwang, Jiann Loung. AU - Huang, Lee W.. AU - Chen, Heng J.. PY - 2005/8. Y1 - 2005/8. N2 - STUDY OBJECTIVE: To assess the efficacy of sublingual buprenorphine in the relief of pain associated with office hysteroscopy. DESIGN: Prospective, randomized study (Canadian Task Force classification I). SETTING: Tertiary medical center. PATIENTS: One hundred sixty-four women referred for office hysteroscopy from September 2003 through March 2004. INTERVENTION: Before hysteroscopy, 80 women received a tablet of buprenorphine (group A), and 84 women received a placebo (group B). Their pain sensations were evaluated on a 10-cm visual analog scale, and they were asked about the adverse reactions and level of satisfaction on the following day. MEASUREMENTS AND MAIN RESULTS: The pain score in group A was 3.3 ± 1.1, which was similar to 3.2 ± 1.3 in group B. The pain scores in subgroups of women ...
The field of rectal and vaginal microbicides is a new therapeutic area with several candidates in clinical trials and no registered products. Many of these candidates, with the exception of a 1% tenofovir gel evaluated in the recent CAPRISA 004 trial (1), have failed to demonstrate safety or efficacy. Despite these setbacks, the field is still progressing rapidly due to the pressing need for prophylactic technologies and the advantages of vaginal route of delivery for antiretroviral drugs (9, 16). Typically, drugs delivered through the vaginal route encounter an acidic environment with pH ranging from 4.0 to 5.0 (37, 40). However, soon after intercourse, the vaginal pH increases to a neutral pH due to the introduction of semen. The vaginal environment also hosts several Lactobacillus strains that constantly generate lactic acid and hydrogen peroxide, maintaining an acidic pH in the vaginal cavity (37, 40). Therefore, successful development of a vaginal microbicide product requires an active ...
In this study, we will compare the safety and efficacy of 400 mcg sublingually administered misoprostol alone to standard surgical care for the treatment of incomplete abortion. This study will provide important data on the role of misoprostol in health services offering an array of treatments for incomplete abortion. Women could significantly benefit from a non-invasive treatment option for incomplete abortion. While safe surgical services are becoming more widespread, there is still a serious risk of complications from these procedures. Especially in developing countries, infection, hemorrhage and uterine damage are still too common. Medical treatment of incomplete abortion using misoprostol would be a tremendous step to reducing morbidity and mortality due to abortion complications ...
Title: Incidence of legal abortion in Sweden after the Chernobyl accident. Author: V Odlind, A Ericson. Reference: Biomedicine & Pharmacotherapy, Volume 45, Issue 6, 1991, Pages 225-228. DOI: http://dx.doi.org/10.1016/0753-3322(91)90021-K. Keywords: Chernobyl, abortion. Abstract: The number of legal abortions in Sweden increased around the time of the Chernobyl accident, particularly in the summer and autumn of 1986. Although there was no recording of reasons for legal abortions, one might have suspected this increase to be a result of fear and anxiety after the accident. However, seen over a longer time perspective, the increase in the number of abortions started before and continued far beyond the time of the accident. There was also a simultaneous and pronounced increase in the number of births during the years subsequent to the accident. Therefore, it seems unlikely that fear of the consequences of radioactive fall-out after the Chernobyl accident resulted in any substantial increase of the ...
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Achilles, S. L., & Reeves, M. F. (2011). Society of Family Planning Clinical Guideline 20102: Prevention of infection after induced abortion. Contraception, 83(4), 295-309.. American College of Obstetricians and Gynecologists. (2014). Practice Bulletin No. 143: Medical management of first-trimester abortion. Obstetrics & Gynecology, 123(3), 676-692.. Chen, M. J., & Creinin, M. D. (2015). Mifepristone with buccal misoprostol for medical abortion: A systematic review. Obstetrics & Gynecology, 126(1), 12-21.. Cohen, A. L., Bhatnagar, J., Reagan, S., Zane, S. B., D'Angeli, M. A., Fischer, M., … McDonald, L. C. (2007). Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and spontaneous abortion. Obstetrics & Gynecology, 110(5), 1027-1033.. Fischer, M., Bhatnagar, J., Guarner, J., Reagan, S., Hacker, J. K., Van Meter, S. H., & Zaki, S. R. (2005). Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. New England Journal of ...
TY - JOUR. T1 - Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques. AU - Pereira, Lara E.. AU - Mesquita, Pedro M.M.. AU - Ham, Anthony. AU - Singletary, Tyana. AU - Deyounks, Frank. AU - Martin, Amy. AU - McNicholl, Janet. AU - Buckheit, Karen W.. AU - Buckheit, Robert W.. AU - Smith, James M.. N1 - Publisher Copyright: © 2016, American Society for Microbiology. All Rights Reserved.. PY - 2016/3. Y1 - 2016/3. N2 - We evaluated the in vivo pharmacokinetics and used a complementary ex vivo coculture assay to determine the pharmacodynamics of IQB3002 gel containing 1% IQP-0528, a nonnucleoside reverse transcriptase inhibitor (NNRTI), in rhesus macaques (RM). The gel (1.5 ml) was applied vaginally to 6 simian-human immunodeficiency (SHIV)-positive female RM. Blood, vaginal fluids, and rectal fluids were collected at 0, 1, 2, and 4 h. RM were ...
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A Caesarean Scar ectopic pregnancy is a non-tubal ectopic pregnancy and is one of the rarest forms of ectopic pregnancies. However with caesarean sections being one of the most common operations performed in the developed world and the number of women having caesarean sections increasing, the incidence of caesarean scar ectopic pregnancies is also increasing.. A caesarean scar ectopic pregnancy occurs when the pregnancy implants in the lower part of the uterus, on the scar performed at the time of a caesarean section. The concern with a caesarean scar ectopic pregnancy, is that if the pregnancy continues, the placenta will become deeply embedded within the scar and in some cases may continue through the scar and grow towards the bladder. This can result in rupture of the womb in the most severe cases. It is extremely rare that a caesarean scar ectopic pregnancy will continue and cases lasting to the third trimester are associated with a morbidly adherent placenta and a high risk of severe ...
TY - JOUR. T1 - Association between fluid management and dilutional coagulopathy in severe postpartum haemorrhage. T2 - a nationwide retrospective cohort study. AU - Gillissen, Ada. AU - van den Akker, Thomas. AU - Caram-Deelder, Camila. AU - Henriquez, Dacia D. C. A.. AU - Bloemenkamp, Kitty W. M.. AU - van Roosmalen, Jos J. M.. AU - Eikenboom, Jeroen. AU - van der Bom, Johanna G.. AU - Henskens, Yvonne. AU - Scheepers, Liesbeth. AU - TeMpOH-1 study Grp. PY - 2018/10/11. Y1 - 2018/10/11. KW - Coagulation parameters. KW - Dilutional coagulopathy. KW - Fluid management. KW - Postpartum haemorrhage. KW - COLLOID PLASMA EXPANDERS. KW - OBSTETRIC HEMORRHAGE. KW - RESUSCITATION. KW - HEMODILUTION. KW - COAGULATION. U2 - 10.1186/s12884-018-2021-9. DO - 10.1186/s12884-018-2021-9. M3 - Article. C2 - 30305108. VL - 18. JO - BMC Pregnancy and Childbirth. JF - BMC Pregnancy and Childbirth. SN - 1471-2393. M1 - 398. ER - ...
Northern Ireland's Department of Health told a Belfast daily on Friday that women who self-administer medical abortions at home are at risk.
Impact of level of researcher support on coital diary results and acceptability among women at high risk of HIV in the microbicides development programme feasibility study in Mwanza, Tanzania ...
Bacterial vaginosis (BV) is a disease of the vagina caused by bacteria. The most common symptom of BV is an abnormal homogeneous off-white vaginal discharge (especially after sex) with an unpleasant smell. This is a Phase II, Double-Blind, Randomized, Placebo-Controlled, Multi-center Trial enrolling 120 women, 18-50 years old, with clinical evidence of bacterial vaginosis. Subjects will be randomized at a ratio of 2:1 to receive active test article (5% Monolaurin Vaginal Gel) or placebo (vehicle) as outpatient therapy. Subjects will be stratified by first time episode of bacterial vaginosis or recurrent bacterial vaginosis. The primary objectives of this study are: 1) To assess the safety and tolerability of 5% Monolaurin Vaginal Gel compared to Vehicle Placebo Gel (excipients only) and 2) To assess the efficacy by clinical cure rate of 5% Monolaurin Vaginal Gel compared to Vehicle Placebo Gel at Visit 2. The secondary objectives are : 1) To evaluate the therapeutic cure rate of 5% Monolaurin ...
An abortifacient ("that which will cause a miscarriage" from Latin: abortus "miscarriage" and faciens "making") is a substance that induces abortion. Abortifacients for animals that have mated undesirably are known as mismating shots. Common abortifacients used in performing medical abortions include mifepristone, which is typically used in conjunction with misoprostol in a two-step approach. Oxytocin is commonly used to induce abortion in the second or third trimester. There are also several herbal mixtures with abortifacient claims, though there are no available data on the efficacy of these plants in humans. Prostaglandin analogues, such as misoprostol or gemeprost (both synthetic prostaglandin E1 (PGE1) analogues), are often used to terminate pregnancy up to 24 or 60 days of gestation, in combination with mifepristone (a progesterone receptor antagonist) or methotrexate (an antifolate). Misoprostol administered vaginally is more effective than when administered orally. Misoprostol is ...
AUSTIN, Texas (AP) - The Republican-controlled Texas Legislature is poised to restrict insurance coverage for abortions over the objections of opponents who say doing so could force some women to make heart-wrenching choices because no exceptions will be made in cases of rape and incest.. A bill requiring women to purchase extra insurance to cover abortions except amid medical emergencies already cleared the state House after hours of emotional debate. The Texas Senate could approve it Saturday night, sending the restrictions to Republican Gov. Greg Abbott to be signed into law.. State lawmakers debated other bills limiting insurance coverage for abortion during Texas' regular legislative session that ended in May, but Abbott called a special session and revived the issue.. Ten states already have laws restricting insurance coverage of abortion in all private insurance plans: Idaho, Indiana, Kansas, Kentucky, Michigan, Missouri, Nebraska, North Dakota, Oklahoma and Utah. All make exceptions if ...
Product Name: Mifepristone and Misoprostol Tablets. Common Name: contraceptive pills. Strength: available in -. Mifepristone IP 200mg & Misoprostol IP 200mcg. Description: Medical Abortion is a form of early abortion caused by the combination of two medications, mifepristone and misoprostol that is an option for women who are 8 weeks pregnant or less. Also known as RU486 or medication abortion.. During the first appointment at the clinic you receive the mifepristone pill to take orally. Then 24 to 72 hours later, in the privacy, take the the second medication, misoprostol. Misoprostol causes contractions resulting in a miscarriage. When used in combination, mifepristone and misoprostol are 95-97% effective within two weeks. Mifepristone and misoprostol are FDA approved.. Indications and Usage: Mifepristone is used in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 70 days or less since your last menstrual period began. Mifepristone is in a ...
The second part describes the management of an incomplete evacuation of the uterus after misoprostol use for first trimester miscarriage. Although women with an incomplete evacuation are often relatively asymptomatic, a curettage is often performed. We conducted a randomized controlled trial, comparing curettage to expectant management. A cohort study was conducted alongside this trial following women who received treatment of their preference. These studies show, that although curettage is slightly more effective, expectant management is safe and also effective in at least 5 out of 6 women. Quality of life did not differ between randomized women, and in the cohort, women who underwent expectant management reported a slightly better quality of life. Furthermore, curettage does not seem cost effective over expectant management in women with an incomplete evacuation. In these studies we found no differences in subsequent pregnancy rates or pregnancy outcomes ...
|p|A regimen of mifepristone and misoprostol was significantly more effective for termination of pregnancies | or = 56 days than misoprostol alone. The 88% efficacy obtained with vaginal misoprostol alone may be clinically acceptable when mifepristone is not available.|/p|
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TY - JOUR. T1 - Postpartum hemorrhage caused by uterine artery pseudoaneurysm and uterine rupture after vaginal delivery. AU - Origoni, Massimo. AU - Gelardi, Chiara. AU - Pasi, Federica. AU - Salvatore, Stefano. AU - Candiani, Massimo. PY - 2012/7. Y1 - 2012/7. N2 - A case of massive hemoperitoneum determined by uterine rupture and uterine artery pseudoaneurysm dissection after vaginal delivery, requiring an emergency laparotomy with arterial ligation, is reported. The authors reviewed the published literature, finding 12 cases of uterine artery pseudoaneurysm and associated postpartum hemorrhage after vaginal delivery, but no cases with uterine rupture have ever been published. Diagnosis is based upon imaging, and management options include arterial embolization, arterial ligation and hysterectomy in particularly severe and life-threatening situations. Vaginal bleeding is associated with favorable outcomes and conservative treatment, while the absence of external blood loss seems to be ...
Outpatient or office hysteroscopy has become the 'gold standard' for the investigation of the intrauterine abnormalities. This minimal invasive modality provides brilliant and clear visualization of the entire uterine cavity and besides this, by the operative channel, minor procedures may easily be performed in the office setting which is priceless for the gynecologist. However, pain related to the procedure may make the procedure uncomfortable for the patient and the physician. Together with the operative time, hysteroscope diameter is considered as the main factor influencing pain. The pain perceived during hysteroscopy may be reduced by using a smaller diameter hysteroscope or by using anesthesia, which decreases pain perception.. In this prospective, randomized, double blind, placebo controlled study, we aim to compare the effectiveness of sublingual misoprostol versus lidocaine pump spray for pain relief during office hysteroscopy. ...
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BACKGROUND: Induction of labour is a common obstetric procedure. Both mechanical (eg, Foley catheters) and pharmacological methods (eg, prostaglandins) are used for induction of labour in women with an unfavourable cervix. We aimed to compare the effectiveness and safety of induction of labour with a Foley catheter with induction with vaginal prostaglandin E2 gel.. METHODS: We did an open-label, randomised controlled trial in 12 hospitals in the Netherlands between Feb 10, 2009, and May 17, 2010. We enrolled women with a term singleton pregnancy in cephalic presentation, intact membranes, an unfavourable cervix, an indication for induction of labour, and no prior caesarean section. Participants were randomly allocated by an online randomisation system to induction of labour with a 30 mL Foley catheter or vaginal prostaglandin E2 gel (1:1 ratio). Because of the nature of the intervention this study was not blinded. The primary outcome was caesarean section rate. Secondary outcomes were maternal ...
We report a rare case of bilateral tubal ectopic pregnancy following day 5 embryo transfer. A 35 year-old woman with a 17 year history of primary male factor infertility underwent IVF cycle with standard long protocol. Three Morulla stage embryos were transferred 120 hours after oocyte...