Aizawa Y and Ishii S (2003). Cloning of complimentary deoxyribonucleic acid encoding follicle-stimulating hormone and luteinizing hormone beta subunit precursor molecules in Reevess turtle (Geoclemys reevesii) and Japanese grass lizard (Takydromus tachydromoides). Gen. Comp. Endocrinol. 132: 465-473. doi:10.1016/S0016-6480(03)00103-5 Barreau C, Paillard L and Osborne HB (2005). AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res. 33: 7138-7150. doi:10.1093/nar/gki1012 PMid:16391004 PMCid:1325018 Chien JT, Shen ST, Lin YS and Yu JY (2005). Molecular cloning of the cDNA encoding follicle-stimulating hormone beta subunit of the Chinese soft-shell turtle Pelodiscus sinensis, and its gene expression. Gen. Comp. Endocrinol. 141: 190-200. doi:10.1016/j.ygcen.2004.12.017 PMid:15748721 Dai L, Zhao Z, Zhao R, Xiao S, et al. (2009). Effects of novel single nucleotide polymorphisms of the FSH beta-subunit gene on semen quality and fertility in bulls. Anim. Reprod. Sci. ...
STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: the T allele of the FSHB promoter polymorphism (rs10835638; c.-211G,T) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective against endometriosis. WHAT IS KNOWN ALREADY: the FSHB promoter polymorphism (rs10835638; c.-211G,T) affects levels of FSHB transcription and, as a result, circulating levels of FSH. FSH is required for normal fertility and genetic variants at the FSHB locus are associated with age at menopause and polycystic ovary syndrome (PCOS). STUDY DESIGN, SIZE, DURATION: We used cross-sectional data from the UK Biobank to look at associations between the FSHB promoter polymorphism and reproductive traits, and performed a genome-wide association study (GWAS) for length of menstrual cycle. PARTICIPANTS/MATERIALS, SETTING, METHODS: We included white British individuals aged 40-69 ...
STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: the T allele of the FSHB promoter polymorphism (rs10835638; c.-211G,T) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective against endometriosis. WHAT IS KNOWN ALREADY: the FSHB promoter polymorphism (rs10835638; c.-211G,T) affects levels of FSHB transcription and, as a result, circulating levels of FSH. FSH is required for normal fertility and genetic variants at the FSHB locus are associated with age at menopause and polycystic ovary syndrome (PCOS). STUDY DESIGN, SIZE, DURATION: We used cross-sectional data from the UK Biobank to look at associations between the FSHB promoter polymorphism and reproductive traits, and performed a genome-wide association study (GWAS) for length of menstrual cycle. PARTICIPANTS/MATERIALS, SETTING, METHODS: We included white British individuals aged 40-69 ...
Grasso P، Rozhavskaya-Arena M، Reichert LE (1999). "Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle". Regul. Pept. 81 (1-3): 67-71. PMID 10395410. doi:10.1016/S0167-0115(99)00022-1. ...
Complete information for FSHB gene (Protein Coding), Follicle Stimulating Hormone Beta Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
A novel clinical-grade CD40L reagent was developed to test the hypothesis that immunization with functionally mature IL-12p70-producing DCs elicits effective CD8+ T immunity in patients with newly diagnosed advanced melanoma. Immunological responses to the gp100 antigen were observed in 6 of the 7 treated patients, while clinical response (as defined by RECIST criteria) was observed in 3 of 7 patients. Importantly, IL-12p70 levels produced by patient-derived CD40L/IFN-γ-activated mDCs as well as the development of antitumor Tc1 CD8+ T cell immunity correlated with TTP. Impairment in IL-12p70 production by CD40L/IFN-γ activated mDCs was observed in the 4 clinical nonresponder patients (all with Tc2-skewed immunity), and this deficiency resulted from impaired IL-12p35 subunit transcription. However, incorporating TLR3 and TLR8 signals with CD40L/IFN-γ activation corrected the IL-12p70 production defect in clinical nonresponder patient DCs, suggesting new ways to improve vaccine efficacy in ...
SAFWAT, NEDAL WAFIK. Activin Induction of Follicle Stimulating Hormone is Mediated by Transforming Growth Factor Beta Activated Kinase-1 (TAK-1) in Pituitary Gonadotropes (Under the direction of William L. Miller.) Follicle stimulating hormone (FSH) is an essential hormone for female folliculogenesis and plays an important role in male spermatogenesis. The hormone is secreted by pituitary gonadotropes in the anterior pituitary lobe, and its overall production is regulated by expression of the FSH? subunit. The regulation of FSH? subunit is achieved by combined actions of neurocrine, endocrine, and pituitary paracrine/autocrine factors. Activin shown to be produced locally within the pituitary is a potent stimulator of the FSH? subunit. This study used 4.7 kb of the ovine FSH? promoter linked to luciferase (oFSH?Luc) plus a well characterized activins responsive construct, p3TPLuc, to investigate the hypothesis that Smad3, TAK1 (TGF? activated kinase1), or both cause activin-mediated induction of ...
Supplier: Elabscience Product Type: ELISA Kit Size: 96T Description: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse INHBP . Standards or samples are added to the appropriate micro ELISA plate wells and combined with the
The three reports describing NF-H-null mice indicate that this subunit is less important than NF-M for NF assembly and structure. Although all three groups used essentially that same experimental procedures for establishing their mutant mice, we were amazed at the striking differences in morphological phenotype in samples taken from the same region at the same age. Here we will discuss these results in three contexts: (a) expression levels of mRNA and protein, (b) morphometric analysis (axonal caliber, nearest neighbor distance, NF density, MT density), and (c) specific experiments in each paper.. All three reports quantitated the expression level of NF-L and NF-M mRNA, because previous studies had suggested an interrelationship between subunit transcription levels (Tu et al., 1995; Zhu et al., 1997). In this case, however, the effect of NF-H ablation on the mRNA levels for NF-L and NF-M was negligible, suggesting that NF-H expression is relatively independent of the expression of the other two ...
oestrogen stimulates LH production. LH produced by pituitary gland. LH stimulates ovulation LH stimulates formation of corpus luteum LH stimulates production of progesterone (by corpus luteum). progesterone maintains / thickens uterine lining LH inhibits FSH production without ovulation there is no egg release / no egg to fertilise. ...
Polyclonal antibody for beta/FSHB detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. beta/FSHB information: Molecular Weight: 14700 MW; Subcellular Localization: Secreted.
Using the model described above, we considered the situation where two TFs (TF1 and TF2) converge on a single gene promoter that we name GSU (gonadotropin subunit), a generic term used because this is likely to be the case for the αGSU, LHβ and FSHβ gonadotropin subunit genes, as it is for many other ERK and NFAT target genes [8,9,29-33]. We considered the possibility that TF1 is an ERK-activated TF and that TF2 is NFAT (parallel activation network topology) or that TF1 and TF2 are sequentially activated downstream of ERK (sequential activation network topology). We also tested three distinct logic gates for the nature of the action of TF1 and TF2 at the promoter [35]. The first is a CO-OPERATIVE gate that, in biological terms, could reflect the action of one TF to mediate the interaction between the other TF and the cells transcriptional machinery, or alternatively, the requirement of physical interaction between the two TFs to orientate distant promoter sites and bring them to close ...
It is widely believed that FSH and LH, which are known to play key roles in controlling the production of functional oocytes in vertebrates, are synthesized and secreted exclusively by the anterior pituitary. Here we present evidence for the novel expression of FSHbeta, LHbeta, and the common glycoprotein-alpha (Cgalpha) in the gilthead seabream ovary. Using in situ hybridization and immunocytochemistry, FSHbeta was detected in primary-growth and secondary-growth-I oocytes, LHbeta was found in secondary-growth oocytes, and Cgalpha was observed in both primary and secondary-growth oocytes. Northern blot analyses demonstrated that Fshbeta transcript is 0.6 kb in both pituitary and ovary, whereas the ovarian Lhbeta transcript (1.1 kb), unexpectedly, is longer than the known pituitary Lhbeta transcript (0.6 kb). Sequence analyses revealed that ovarian Lhbeta is driven by a different promoter than pituitary Lhbeta, which generates an additional 459 bases at the distal portion of the 5-untranslated ...
Gonadotropin expression is precisely regulated within the hypothalamic-pituitary-gonadal axis through the complex interaction of neuropeptides, gon...
There are many versions of it. I use it as part of a antagonist/ganirelex protocol. You prime with straight estrogen before your start your stims, etc. In my case, this cycle i was on estrace 4mg for about 6 weeks. I then added provera to the estrogen for 10 days then stopped both, have your period and proceed with the rest of your protocol. I primed for about 4 weeks for my first ER and 6 for this one. I have 10 baseline follies this time vs. 4 last time. Exposure to the estrogen up-regulates you receptors on your follicles to FSH. It does this by inhibiting normal FSH production. Therefore, your follies have no exposure to FSH for a period of time. When you hit them with stims they respond with much greater sensitivity to it. So you get a better response ...
The purpose of this randomized controlled trial (RCT) is to compare a single injection of corifollitropin-alfa versus daily injections of follitropin beta
Xenopus laevis (X) GnRHRs ( approximately 40%). This distinction is retained at comparable whole cell expression levels, and the hGnRHR PCSE is increased by addition of the XGnRHR C-tail (h.XGnRHR) or by a membrane-permeant pharmacological chaperone (IN3). The IN3 effect is concentration- and time-dependent and IN3 also enhances the hGnRHR-mediated (but not h.XGnRHR- or mouse GnRHR-mediated) stimulation of [(3)H]inositol phosphate accumulation and the hGnRHR-mediated reduction in cell number. We also find that the PCSE for hGnRHRs and h.XGnRHRs is low and is greatly increased by IN3 in two hormone-dependent cancer lines, but is higher and less sensitive to IN3 in a gonadotrope line. Finally, we show that the effect of IN3 on hGnRHR PCSE is not mimicked or blocked by two peptide antagonists although they do increase the PCSE for h.XGnRHRs, revealing that an antagonist-occupied cell surface GnRHR conformation can differ from that of the unoccupied receptor. The low PCSE of hGnRHRs and this novel ...
Get information, facts, and pictures about gonadotropic hormone at Encyclopedia.com. Make research projects and school reports about gonadotropic hormone easy with credible articles from our FREE, online encyclopedia and dictionary.
How is Porcine Follicle-Stimulating Hormone abbreviated? pFSH stands for Porcine Follicle-Stimulating Hormone. pFSH is defined as Porcine Follicle-Stimulating Hormone rarely.
This two-year individual NRSA training fellowship application outlines the training and research plans for Dr. Danalea Skarra. Dr. Skarra has designed an integr...
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Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice.: Follicle-stimulating hormone (FSH; follitropin)
PFSH - Pure Follicle-Stimulating Hormone. Looking for abbreviations of PFSH? It is Pure Follicle-Stimulating Hormone. Pure Follicle-Stimulating Hormone listed as PFSH
Synonyms for Follitropin alfa in Free Thesaurus. Antonyms for Follitropin alfa. 1 synonym for follicle-stimulating hormone: FSH. What are synonyms for Follitropin alfa?
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM ...
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FSH Levels Definition - FSH (follicle-stimulating hormone) levels in women are measured on day 3 of the menstrual cycle to evaluate menstrual...
Online Doctor Chat - Problem in conceiving, irregular periods, Ask a Doctor about Follicle-stimulating hormone, Online doctor patient chat conversation by Dr. Jyoti Patil
Looking for online definition of chorionic gonadotropic hormone in the Medical Dictionary? chorionic gonadotropic hormone explanation free. What is chorionic gonadotropic hormone? Meaning of chorionic gonadotropic hormone medical term. What does chorionic gonadotropic hormone mean?
Looking for online definition of follicle-stimulating principle in the Medical Dictionary? follicle-stimulating principle explanation free. What is follicle-stimulating principle? Meaning of follicle-stimulating principle medical term. What does follicle-stimulating principle mean?
The results of the present work showed that administration of ERα-subtype-selective ligand PPT (Stauffer et al. 2000) in ovariectomized rats had oestrogen activity on all parameters of gonadotrope function analysed, whereas administration of ERβ-subtype-selective ligand DPN (Meyers et al. 2001) mimicked all actions of PPT except the reduction of pituitary content and serum concentration of LH. The latter action, however, was the only one not affected when both ER ligands were administered simultaneously. Morphological parameters of gonadotrope function evaluated were qualitative characteristics of the membrane-enclosed intracellular organelles, gonadotrope size, and PR expression status. In fact, due to the pivotal role of PR in gonadotrope function in the rat (Fink 2000), we used the immunohistochemical expression of PR in gonadotropes to classify them as activated (with PR expression) or hypertrophied (without PR expression).. In the rat, the presence of PR in gonadotropes is an absolute ...
Doctors help you with trusted information about Ovarian in Ovarian Cyst: Dr. Holtz on how to shrink ovarian cysts herb: FSH (Follicle Stimulating Hormone) produced in the pituitary signals ovarian follicles to grow, sometimes to the size of a cyst. Estrogen in birth control pills suppresses FSH production. Less FSH, less growth of cysts.
Easy to read patient leaflet for Follitropin Alfa. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Synonyms for FSH in Free Thesaurus. Antonyms for FSH. 1 synonym for FSH: follicle-stimulating hormone. What are synonyms for FSH?
Follitropin Alfa - Get up-to-date information on Follitropin Alfa side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Follitropin Alfa
This medication contains follicle-stimulating hormone (FSH) and is used to treat certain fertility problems in women. Follitropin alfa helps stimulate healthy ovaries to produce eggs. This medication is usually used in combination with another hormone (hCG) to bring about the growth and release of a mature egg...
Cinnal-f® (Follitropin alfa) is a recombinant DNA origin based hormone identical to follicle-stimulating hormone (FSH) produced by the pituitary gland. FSH helps to develop eggs in the ovaries.
Learn about Follistim AQ (Follitropin Beta) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
low fsh - MedHelps low fsh Center for Information, Symptoms, Resources, Treatments and Tools for low fsh. Find low fsh information, treatments for low fsh and low fsh symptoms.
اطلاعات مندرج در این پایگاه فقط جهت مطالعه کاربران با رعایت شرایط اعلام شده است. نسخه‌برداری و بازنشر اطلاعات به هر روش، در هر نوع رسانه و با هر هدفی ممنوع و پیگرد قانونی دارد. ...
Root cap. Coloured scanning electron micrograph (SEM) of the root cap of wheat, (Triticum vulgare). The root cap produces a slimy mucous that lubricates the passage of the root through the soil. The cells that produce the slime are continually sloughed off, a mechanism that enables the constant renewal of this protective layer. The cells at the root tip are firmly embedded in slime (blue), while further back loose cells are shed. Root hairs, seen in the background, appear at a distance behind the tip and greatly increase the roots absorptive surface area. Roots anchor a plant in the soil and extract water and nutrients. Magnification: x220 when printed 10 cm tall. - Stock Image B705/0092
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM][1] ...
TY - JOUR. T1 - Gonadal development and expression profiles of gonadotropin genes in wild sea conger, Ariosoma meeki. AU - Ishii, S.. AU - Yoshiura, Y.. AU - Kajimura, S.. AU - Mochioka, Noritaka. AU - Aida, K.. PY - 2003. Y1 - 2003. N2 - Reproductive physiology of an anguilliform fish, wild sea conger (Ariosoma meeki) was studied. Spawning season of this species is between July and August, and their oocytes showed synchronous development. mRNA levels of GTH subunits increased in accordance with gonadal development and decreased after spawning. Present results were inconsistent with our previous results in artificially matured Japanese eel.. AB - Reproductive physiology of an anguilliform fish, wild sea conger (Ariosoma meeki) was studied. Spawning season of this species is between July and August, and their oocytes showed synchronous development. mRNA levels of GTH subunits increased in accordance with gonadal development and decreased after spawning. Present results were inconsistent with our ...
article{20d48e6c-fa57-43f8-9d78-27aa9c69d734, abstract = {,p,OBJECTIVE: The aim of this study was to characterise the population pharmacokinetics of FE 999049, a novel recombinant human follicle-stimulating hormone (FSH), after multiple dosing in healthy women, taking into account endogenous FSH levels and the reproductive hormone dynamics.,/p,,p,METHODS: Longitudinal measurements of FSH, luteinising hormone, progesterone, estradiol, and inhibin B levels were collected after repeated subcutaneous dosing with 225 IU of FE 999049 in 24 gonadotropin downregulated healthy women. The FSH data were described using nonlinear mixed-effects modelling.,/p,,p,RESULTS: The measured FSH levels were modelled as a sum of endogenous FSH and FE 999049. The FE 999049 population pharmacokinetics were best described using a one-compartment model with first-order absorption and elimination, and a transit model for delayed absorption. The apparent clearance and volume of distribution increased with body weight in ...
Follicle-stimulating hormone (abbreviated FSH, sometimes called Follitropine) is a glycoprotein and sex steroid. It is synthesised in the adeno hypophysis of pituitary gland. In females it will cause the growth of follicles in the ovaries and controlls the synthesising process of progesteron, in males, it will lead to the production of sperm. Other hormones control the release of FSH. Luteinizing hormone will cause ovulation in females, or the production of testosterone in males. ...
Ovulation is the process of the release of an oocyte that can be fertilised.. For the maturation of the ovarian follicle and the release of an oocyte, two weeks are usually required. In the first stage of the menstrual cycle, the hypophysis excretes the hormone FSH that later on triggers the ovary for the production and the maturity of one or more follicles. The follicles during their development produce oestrogens. The increase of oestrogens causes a negative control in the FSH production and as a result its production is decreased. That decrease in FSH permits in only one of the ovarian follicles to continue its growth until the final stages. The continuous increase of oestrogens leads to the production of the LH hormone from the hypophysis. In a menstrual cycle of 28 days, the sudden increase of LH on the 12th day of the cycle helps the follicle to mature and to release the mature oocyte (ovulation).. Ovulation occurs 36 hours after the increase of LH. Right after its release, the oocyte is ...