The main finding of the current study was the significant lower level of serum folic acid in women with PTB and folic acid level was associated with lower risk of PTB. This goes with the previous studies where Chen et al., have reported that higher plasma folate concentrations were associated with a longer gestational age and associated with lower risk of PTB [9]. Likewise Furness et al., have shown that women who had a lower Red blood cells (RBCs) folate level in early (12-14 weeks) pregnancy were 5.4 times at higher risk to have PTB [11]. In a large clinical trial, it has recently been shown consumption of folic acid/ other micronutrient in the first trimester lead to a 41%-45% risk reduction for PTB [17].. In contrast to our findings, it has recently been reported that supplemental folate intake was not significantly associated with the risk of PTB [12]. Interestingly, women who received folic acid supplementation more than 8 weeks before conception were at increased risk for PTB compared ...

PubMed journal article Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate statu were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.

By Tori Hudson, ND. Author: Askari G, Nasiri M, Mozaffari-Khosravi M, et al.. Reference: The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition 2017;38:4-79.. Design: This was a parallel, double-blind, randomized placebo-controlled, clinical trial conducted in 95 patients with migraines/aura. Patients were randomly allocated to one of three groups of folic acid plus pyridoxine (n=34), folic acid alone (n=34) or placebo (n=34). Serum homocysteine levels were evaluated. Characteristics were determined including severity, frequency, duration, and duration per attack.. Patients in the folic acid plus pyridoxine group received 5 mg folic acid and 80 mg pyridoxine daily; the folic acid group only received 5 mg/day and the placebo group received lactose capsules. All patients received routine treatment for their migraines which they had previously been taking ...

Birth defects are a major cause of infant mortality and disability in many parts of the world. Neural tube defects (NTDs) are one of the most common types of birth defects. In 2001, the Chinese population and family planning commission initiated a national intervention program for the prevention of birth defects. A key step in the program was the introduction of folic acid supplementation. Of interest in the present study was to determine whether folic acid supplementation has the same protective effect on NTDs under various geographical and socioeconomic conditions within the Chinese population and the nature in which the influence of environmental factors varied after folic acid supplementation. In this study, Heshun was selected as the region of interest as a surrogate for helping to answer some of the questions raised in this study on the impact of the intervention program. Spatial filtering in combination with GIS software was used to detect annual potential clusters from 1998 to 2005 in Heshun,

Birth defects are a major cause of infant mortality and disability in many parts of the world. Neural tube defects (NTDs) are one of the most common types of birth defects. In 2001, the Chinese population and family planning commission initiated a national intervention program for the prevention of birth defects. A key step in the program was the introduction of folic acid supplementation. Of interest in the present study was to determine whether folic acid supplementation has the same protective effect on NTDs under various geographical and socioeconomic conditions within the Chinese population and the nature in which the influence of environmental factors varied after folic acid supplementation. In this study, Heshun was selected as the region of interest as a surrogate for helping to answer some of the questions raised in this study on the impact of the intervention program. Spatial filtering in combination with GIS software was used to detect annual potential clusters from 1998 to 2005 in Heshun,

TY - JOUR. T1 - Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age. AU - Cheong, Magdalin. AU - Xiao, Huang Ying. AU - Tay, Vicky. AU - Karakochuk, Crystal D.. AU - Liu, Yazheng Amy. AU - Harvey, Sarah. AU - Lamers, Yvonne. AU - Houghton, Lisa A.. AU - Kitts, David D.. AU - Green, Tim J.. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Background and Objectives: Folic acid (400 μg/d) taken during the periconceptional period reduces neural tube defect (NTD) risk by , 75%. Achieving red cell folate (RCF) or plasma folate (PF) , 905 nmol/L and , 35 nmol/L, respectively, has been associated with a low risk of NTDs. We determined whether daily consumption of folic acid fortified milk increases blood folate concentrations to levels associated with a low risk of NTDs in Singaporean women of childbearing age. Methods and Study Design: In this double-blind placebo-controlled trial, 70 non-pregnant women ...

TY - JOUR. T1 - Expression of a folate binding protein in L1210 cells grown in low folate medium. AU - Jansen, G. AU - Kathmann, I. AU - Rademaker, B C. AU - Braakhuis, B J. AU - Westerhof, G R. AU - Rijksen, G. AU - Schornagel, J H. PY - 1989/4/15. Y1 - 1989/4/15. N2 - We have isolated variants of L1210 cells (L1210B) expressing, in addition to the classical high affinity/low capacity system for reduced folate uptake, high levels of a membrane-associated folate binding protein. This folate binding protein was expressed in L1210 cells grown at low physiological folate levels (less than 0.5 nM), but down-regulated after transfer in standard high folate (2 microM) medium. The binding capacity of L1210B cells for [3H]folic acid and [3H]-methotrexate was identical (5-11 pmol/10(6) cells) but affinities were different. The affinities relative to folic acid were 0.5 for 5-methyltetrahydrofolate, 0.25 for 5-formyltetrahydrofolate, 0.08 for 10-ethyl-10-deazaaminopterin, and 0.05 for methotrexate, ...

Background: Clinical studies suggest that mild methylenetetrahydrofolate reductase (MTHFR) deficiency and high dietary folate may reduce the risk for colorectal cancer. There is concern, however, that high folate intake (a consequence of food fortification) may enhance tumour growth in individuals with pre-existing tumours or genetic predisposition to tumorigenesis.. Aim: To determine if Mthfr deficiency and low dietary folate influence tumorigenesis in mice genetically predisposed to form numerous intestinal adenomas (Apcmin/+).. Methods: Male Apcmin/+ mice were mated with Mthfr+/− and/or Mthfr+/+ females. Diets with variable folate content were administered either pre-natally or at weaning; tumours were counted in offspring at 10 weeks of age. Plasma homocysteine and levels of apoptosis, DNA methylation and nucleotide ratios (dUTP:dTTP) in normal (pre-neoplastic) intestine were measured.. Results: Apcmin/+ mice fed high folate diets from weaning developed more adenomas than those fed the ...

Low blood folate levels result in hyperhomocysteinemia, which has been associated with increased risk for cardiovascular disease, neural tube defects and cognitive deficits. Intake of dietary folates is the chief determinant of blood folate levels. Molecular defects in the intestinal absorption of dietary folates that precipitate low blood folate levels and hyperhomocysteinemia have not been investigated previously. Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. We cloned GCPII cDNA from human intestine and identified both a full-length transcript and a 93 bp shorter transcript lacking exon 18, consistent with the presence of a splice variant. In addition, we identified an H475Y polymorphism in GCPII in DNA samples from a healthy Caucasian population

methyl-life.com has more Info on Folic Acid Deficiency - . Folate deficiency symptoms will begin to appear when an individuals diet does not have enough natural folic acid sources. Explore Methyl-Life to recover fast from Folic Acid Deficiency. visit more http://methyl-life.com/...

The report also said that it is difficult to estimate the impact folic acid fortification have on the prevalence of NTDs in New Zealand because there is no reliable data on the current prevalence of NTD pregnancies.. The general folate status of New Zealand women of child-bearing age is very good. It is the same as, or better than, that of women in the US after the introduction of mandatory fortification,​ Smith and Refsum said.. Based on the best evidence available, we suggest that fortification may prevent no more than 6 NTD pregnancies per year, but quite possibly none, ​they said.. Very few other benefits​. The report also suggested that there are rather few population studies on other possible beneficial effects of folic acid fortification.. The data on other congenital defects is inconsistent and this may in part be due to changes in diagnostic practice over time. Some defects appeared to be more common after fortification, while others may have decreased, ​they said.. The ...

Over three years have passed since an increase in the intake of folic acid among women planning a pregnancy was shown to prevent most neural tube defects.1 The evidence is conclusive; prevention is effective for women who have not had a pregnancy in which the fetus had a neural tube defect as well as for those who have.2 National authorities have recommended that women planning a pregnancy should increase their intake of folic acid.3 4 5 The extra folic acid needed for a reasonable protective effect is 0.4 mg a day, twice the current average dietary intake of 0.2 mg. If no screening was carried out for neural tube defects (with subsequent abortions) about 1500 affected children would be born each year in Britain. Over 1000 of these defects could be prevented by women consuming extra folic acid. Sadly, most people are still not aware of the importance of folic acid in the prevention of neural tube defects.6 7 A public health initiative is urgently needed; the tragedy of a pregnancy in which the ...

Received: 23 Dec, 2008 : Accepted: 8 July 2009 Abstract Background & Aims: Major depression is a mood disorder and the most common psychological disorder. As consistent findings in the major depressive disorder (MDD) denote for a low plasma folate and elevated plasma homocysteine concentration s the results of studies are controversary. In addition, there ...

Many microorganisms and plants possess the ability to synthesize folic acid derivatives de novo, initially forming dihydrofolate. All the folic acid derivatives that serve as recipients and donors of one-carbon units are derivatives of tetrahydrofolate, which is formed from dihydrofolate by an NADPH-dependent reduction catalyzed by dihydrofolate reductase (FolA). This review discusses the biosynthesis of dihydrofolate monoglutamate, its reduction to tetrahydrofolate monoglutamate, and the addition of glutamyl residues to form folylpolyglutamates. Escherichia coli and Salmonella, like many microorganisms that can synthesize folate de novo, appear to lack the ability to transport folate into the cell and are thus highly susceptible to inhibitors of folate biosynthesis. The review includes a brief discussion of the inhibition of folate biosynthesis by sulfa drugs. The folate biosynthetic pathway can be divided into two sections. First, the aromatic precursor chorismate is converted to paminobenzoic acid

Results A total of 112 children receiving antiepileptic monotherapy for ,6 months were enrolled. Hyperhomocysteinaemia was present in 54 children (90%) receiving phenytoin, 45 children (90%) receiving carbamazepine therapy and 17 (34%) controls (p,0.05). Mean plasma homocysteine concentrations were significantly higher (18.9±10.2 vs 9.1±3 µmol/L) and serum folic acid concentrations (10.04±8.5 ng/ml vs 12.6±4.8 p,0.001) and vitamin B12 concentrations (365±155 pg/mL vs 474±332 pg/mL, p=0.02) were significantly lower in the study group compared with the control group. Duration of antiepileptic drug therapy correlated significantly with elevated homocysteine and reduced folic acid concentrations (p,0.05). Supplementation with folic acid for 1 month led to a reduction in plasma homocysteine concentrations in the study group (from 20.9±10.3 µmol/L to 14.2±8.2 µmol/L, p,0.05). ...

Hispanic women are about 20 percent more likely than other women to have babies with those conditions[neural tube defects], and they continue to have far lower levels of folic acid intake, either through diet or supplements, NBC News shared.. The FDA could approve the use of a food additive only after conducting a scientific safety review of the information provided in the petition to ensure that the additive is safe for the general population. With regard to folic acid, the FDA evaluated the projected human dietary exposure, toxicological data, and other relevant information, including whether folic acid remained stable in corn masa flour.. The FDA worked with the petitioners throughout the review process to obtain data needed to address safety questions as expeditiously as possible. Based on that data, the FDA concluded that the petitioned addition of folic acid to corn masa flour at a level not to exceed 0.7 milligrams of folic acid per pound of corn masa flour is safe.. Exposure estimates ...

Methotrexate is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the S phase (of the cell cycle), stopping normal development and division. Methotrexate inhibits folic acid reductase which is responsible for the conversion of folic acid to tetrahydrofolic acid. At two stages in the biosynthesis of purines and at one stage in the synthesis of pyrimidines, one-carbon transfer reactions occur which require specific coenzymes synthesized in the cell from tetrahydrofolic acid. Tetrahydrofolic acid itself is synthesized in the cell from folic acid with the help of an enzyme, folic acid reductase. Methotrexate looks a lot like folic acid to the enzyme, so it binds to it quite strongly and inhibits the enzyme. Thus, DNA synthesis cannot proceed because the coenzymes needed for one-carbon transfer reactions are not produced from tetrahydrofolic acid ...

Methotrexate is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the S phase (of the cell cycle), stopping normal development and division. Methotrexate inhibits folic acid reductase which is responsible for the conversion of folic acid to tetrahydrofolic acid. At two stages in the biosynthesis of purines and at one stage in the synthesis of pyrimidines, one-carbon transfer reactions occur which require specific coenzymes synthesized in the cell from tetrahydrofolic acid. Tetrahydrofolic acid itself is synthesized in the cell from folic acid with the help of an enzyme, folic acid reductase. Methotrexate looks a lot like folic acid to the enzyme, so it binds to it quite strongly and inhibits the enzyme. Thus, DNA synthesis cannot proceed because the coenzymes needed for one-carbon transfer reactions are not produced from tetrahydrofolic acid ...

Dr. Roy Gravel, also a co-author of the study and member of the Alberta Childrens Hospital Research Institute says this study provides a tremendous opportunity to look at the prevention of diseases like spina bifida. The work began as a study of a gene called Mtrr in mice. The goal was to shed light on how a mutation in Mtrr would affect folate metabolism. The multigeneral effect we observed was completely unexpected, says Gravel. The Mtrr gene encodes an enzyme that is key to the metabolism of folic acid and, when mutated, causes similar effects to dietary folic acid deficiency. The researchers found that when either the maternal grandmother or the maternal grandfather had this Mtrr mutation, their genetically normal grandchildren were at risk of a wide spectrum of developmental abnormalities, even if the mutated gene was not inherited through to the next generations. These developmental abnormalities were also seen in the fourth and fifth generations of mice. Through a series of ...

Fig. 1. Methyl donor deficiency induces death of hippocampal neurons and potentiates Aβ toxicity. a, Phase-contrast micrographs showing hippocampal neurons in a control culture and a culture that had been maintained for 48 hr in medium lacking methionine and folic acid. b, Cultures were exposed to control medium, medium lacking l-methionine and folic acid (M/F), medium containing 5 μm Aβ1-42 (Aβ), or medium containing a combination of M/F plus Aβ; neuronal survival was quantified at the indicated time points. Neuronal survival is expressed as a percentage of the initial number of neurons present before experimental treatment (see Materials and Methods). Values are the mean and SD of determinations made in six cultures. c, Cultures were incubated for 48 hr in control medium, medium lacking methionine and folic acid (M/F), medium lacking folate (FA), medium lacking methionine but containing folic acid (M), or medium containing 20 μm methotrexate (Methotr). Neuron survival was quantified ...

Folic acid belongs to the vitamin B group and has an important part to play in the maintenance of health and prevention of a host of disorders. You must ensure that you consume foods high in folic acid; there are several natural sources of folic acid; or boost the daily intake with a supplement. ...

Neural tube defects (NTDs) are malformations of the cranium, spine, and nervous system; types of NTDs include anencephaly, spina bifida, encephalocele, and meningocele. Neural tube defects are a major cause of mortality in newborns and have been estimated to affect 0.5 to 8 per 1000 live births. Health Canada has estimated that 195 Canadian infants are born each year with NTDs. Overall, NTDs affect approximately 300 000 infants worldwide.. Epidemiological studies that associate folate supplementation with a decreased risk of NTDs date back to the 1960s. The most definitive research addressing the benefits of folic acid supplementation in decreasing the risk of NTDs was the multicentre, randomized, double-blind trial by the Medical Research Council in the United Kingdom. 1 The aim of this trial was to evaluate the efficacy of 4-mg doses of folic acid in preventing recurrent NTDs in women who had previously delivered children with NTDs. The trial showed that women randomized to take folic acid ...

The campaigns story is outlined, from the MRCs groundbreaking results, through the recommendation in favour of flour fotification by the Committee on Medical Aspects of Nutrition (COMA), and the UK-wide health education campaign on folic acid, to the refusal of the Food Standards Agency (FSA) to recommend fortification in 2003, and a possible change of heart in 2006.. The cases for and against fortification are summarised, including the significant fall in NTD pregnancies in nations that have fortified, and the allegation that folic acid might mask anaemia symptoms in older people with vitamin B12 deficiency. Meanwhile, over 1,200 NTD pregnancies are continuing to occur annually in the UK.. ASBAHs activities have included lobbying politicians, enlisting the support of experts and organisations, seeking media publicity, and liaising with key government agencies. ...

This supplement is a companion document to the Mandatory folic acid and iodine fortification in Australia and New Zealand: baseline report for monitoring. Additional or updated data are provided on: - folic acid intake and supplement usage for children and pregnant women; - NTD incidence rates; - iodine intake and status for children; - iodine status in regional and remote areas of the Northern Territory.. ...

Binding of 3H-folate in Triton X-100 solubilized human prostate homogenate was of a high-affinity type and displayed apparent positive cooperativity typical of specific folate binding. Radioligand dissociation was slow at pH 7.4, but rapid at pH 3.5. Gel chromatography reveled two major folate binding proteins (Mr≈100 and 25kDa), but only one single band (Mr ≈ 65-70 kDa) was detectable on SDS-PAGE and immunoblotting with rabbit-anti human milk folate binding protein. Concentration of folate binding protein in prostate homogenate expressed as maximum 3H-folate binding was 1.10 nmol/g protein, and the cross-reactivity with rabbit-anti human milk folate binding protein serum was 15% as determined by an enzyme-linked immunosorbent assay (median values; n = 6).. ...

Discusses folic acid deficiency anemia. Discusses role that folic acid (folate) plays in making red blood cells. Covers symptoms and complications of anemia. Covers treatment with diet and daily supplement. Offers list of foods that provide folic acid.

TY - JOUR. T1 - Diastereoisomers of Formaldehyde Derivatives of Tetrahydrofolic Acid and Tetrahydroaminopterin. AU - Horwitz, S. B.. AU - Kwok, G.. AU - Wilson, L.. AU - Kisliuk, R. L.. PY - 1969/1/1. Y1 - 1969/1/1. N2 - Previous work on the diethylaminoethylcellulose chromatography of CH2O derivatives of tetrahydrofolic acid leading to the isolation of diastereoisomers, designated as 5,10-methylene derivatives, was repeated using formaldehyde-14C. The isolated material contained 0.7-0.8 mole of formaldehyde/mole of tetrahydrofolate rather than 1 required for the 5,10-methylene structure. This finding was verified by chemical determination of CH2O on the isolated material. Comparable experiments with CH2O derivatives of tetrahydroaminopterin yielded 0.7 mole of CH2O/mole of tetrahydropteridine. These results suggest that the compounds designated as diastereoisomers of 5,10-methylenetetrahydrofolate are actually complexes which contain 4 molecules of tetrahydropteridine and 3 molecules of ...

Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia. - Mechanism of Action & Protocol.

Synonyms for folic acid antagonist in Free Thesaurus. Antonyms for folic acid antagonist. 2 synonyms for methotrexate sodium: amethopterin, methotrexate. What are synonyms for folic acid antagonist?

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Researchers analyzed language development in 38,954 Norwegian boys and girls whose mothers did or did not take 400 mcg of folic acid per day, from four weeks before becoming pregnant to eight weeks afterward. Norway does not require manufacturers to fortify foods with folic acid.. Doctors measured severe language delay, which they defined as speaking only one word, or making only unintelligible sounds. In children whose moms did not take folic acid, 9 out of 1,000 had severe language delay. For children whose moms did take folic acid, the rate of severe language delay was less than half, or 4 in 1,000.. Reference: JAMA; 2011 Oct 12; Vol. 306, No. 14, 1566-73. ...

Looking for folic acid antagonists? Find out information about folic acid antagonists. see coenzyme coenzyme , any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may... Explanation of folic acid antagonists

Docosahexanoic acid + folic acid + methylcobalamin is used in the treatment of .get complete information about docosahexanoic acid + folic acid + methylcobalamin including usage, side effects, drug interaction, expert advice along with medicines associated with docosahexanoic acid + folic acid + methylcobalamin at 1mg.com

Defective closure of the neural tube during embryogenesis results in serious and common birth defects such as spina bifida and anencephaly. Neural tube defects (NTDS) occur at an average rate in the U.S. of 1 per 1000 live-births with selected ethnic groups having higher or lower prevalence rates. Several investigators have shown a marked decrease in the occurrence and recurrence rates of NTDs with the administration of periconceptional supplemental folic acid. Intracellular folates are believed to be responsible for the reduction in NTDs due to their role in facilitating single-carbon transfers in critical biochemical pathways leading to DNA synthesis. Alterations in the folate pathway could compromise DNA synthesis and cellular proliferation, potentially disrupting normal developmental events. To this end, the genetic regulation of folate internalization is being investigated. The reduced folate carrier (RFC) delivers 5-methyltetrahydrofolate from the folate receptors to the cytoplasm of the ...

In response to mounting evidence from observational studies and randomised trials of the benefits of periconceptional folic acid in reducing the risk of neural tube defects, the National Health and Medical Research Council (NHMRC) recommended that women planning a pregnancy or likely to become pregnant should be offered advice about dietary folate and periconceptional folic acid supplementation. Subsequently an NHMRC Expert Panel on Folate Fortification recommended voluntary folate fortification of foods.

Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits. Folates are required for DNA synthesis and epigenetic regulation. In addition to dietary nutrients, the gut microbiota has been recognized as a source of B complex vitamins, including folate. This study evaluated the predicted folate synthesis capabilities in the genomes of human commensal microbes identified in the Human Microbiome Project and folate production by representative strains of six human intestinal bacterial phyla. Bacterial folate synthesis genes were ubiquitous across 512 gastrointestinal reference genomes with 13% of the genomes containing all genes required for complete de novo folate synthesis. An additional 39% of the genomes had the genetic capacity to synthesize folates in the presence of pABA, an upstream intermediate that can be obtained

Jooma, R. (2004). Preventing neural tube defects by folic acid fortification of flour. JPMA: Journal of the Pakistan Medical Association, 54(11), 2-3 ...

Jooma, R. (2005). Preventing neural tube defects by folic acid fortification of flour. JPMA: Journal of the Pakistan Medical Association, 54(11), 540-541 ...

High plasma homocysteine (Hcy) levels are associated with increased osteoporotic fracture incidence. However, the mechanism remains unclear. We investigated the effect of Hcy-lowering vitamin B,inf,12,/inf, and folic acid treatment on bone mineral density (BMD) and calcaneal quantitative ultrasound (QUS) parameters. This randomized, double-blind, placebo-controlled trial included participants aged ≥65 years with plasma Hcy levels between 12 and 50 µmol/L. The intervention comprised 2-year supplementation with either a combination of 500 µg B,inf,12,/inf,, 400 µg folic acid, and 600 IU vitamin D or placebo with 600 IU vitamin D only. In total, 1111 participants underwent repeated dual-energy X-ray assessment and 1165 participants underwent QUS. Femoral neck (FN) BMD, lumbar spine (LS) BMD, calcaneal broadband ultrasound attenuation (BUA), and calcaneal speed of sound (SOS) were assessed. After 2 years, FN-BMD and BUA had significantly decreased, while LS-BMD significantly increased (all p , ...

Health, ...Neural tube defects in neonates are common in Germany compared with th...A womans folic acid intake before and during early pregnancy ensures ...However the mandatory fortification of foods with folic acid is subje...,Folic,acid,for,everybody,--,arguments,in,favor,of,food,fortification,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

Folate hydrolase 1 (FOLH1) gene encodes intestinal folate hydrolase, which regulates intestinal absorption of dietary folate. Previous studies on the association between polymorphisms rs202676 and rs61886492 and the risk of neural tube defects (NTDs) were inconclusive. A case-control study of women with NTD-affected pregnancies (n = 160) and controls (n = 320) was conducted in the Chinese population of Lvliang, a high-risk area for NTDs. We genotyped the polymorphic sites rs202676 and rs61886492 and assessed maternal plasma folate and total homocysteine (tHcy). Our results showed that in case group, plasma folate concentrations were 18 % lower compared with those of control group (8.32 vs. 6.79 nmol/L, p = 0.033) and tHcy concentrations were 17 % higher (10.47 vs. 12.65 μmol/L, p = 0.047). Almost all samples had the rs61886492 GG genotype (99.78 %). The result showed that the frequency of GG genotype in rs202676 was significantly higher in group with multiple NTDs than in controls (p = 0.030, OR = 2

Our results show that in the UK between 1998 and 2012, there was little, if any, change in the prevalence of pregnancies with an NTD, while in the USA, quickly following the introduction of mandatory fortification of flour with folic acid in 1998, there was an approximate 23% reduction in the occurrence of affected births.2-4 Given the evidence from the MRC Vitamin Study1 regarding the efficacy of folic acid in preventing NTDs, the failure of Britain to fortify flour with folic acid has had significant consequences.. The recent evidence that only 28% of pregnant women in England in 2012 took folic acid supplements at the correct time indicates that, in practice, recommending folic acid supplementation is largely ineffective.19 In addition, a recent report showed that the median level of serum folate in women from the UK aged 16-49 was 7.1 ng/mL in samples obtained from 2008 to 2012.21 This is in comparison with the median levels of 5 ng/mL observed in the samples collected from 1983 to 1991 from ...

treatment with 400 micrograms a day of folic acid, the U.S. recommended dietary allowance, reduced total blood arsenic levels in the study population by 14 percent...Folic acid supplementation enhanced the detoxification of arsenic to a form that is more readily excreted in urine, said Mary Gamble...Folic acid increased the methylation or detoxification of arsenic in the body, allowing the body to change some of its more toxic metabolite, or methylarsonic (MMA) acid, to a form that could more easily be excreted from the body, thus lowering the levels of arsenic found in the blood... ...

These results suggest that folate supplementation might be useful to decrease Al accumulation in its main target organs, i.e., bone, kidney, and brain.

In 2009, Australia implemented mandatory folic acid fortification in wheat flour for bread-making. The primary aim was to improve folate status in reproductive-aged women to reduce neural tube defect incidence. However, folic acid consumption has consequently increased in all demographics. Blood folate is inversely associated with homocysteine levels, a risk factor for multiple diseases. Therefore ...

Periconceptional folic acid use can often prevent neural tube defects (NTDs). Variants of genes involved in folate metabolism in mothers and children have been associated with occurrence of NTDs. We identified Irish families with individuals affected by neural tube defects. In these families, we observed that neural tube defects and birth defects overall occurred at a higher rate in the maternal lineage compared with the paternal lineage. The goal of this study was to look for evidence for genetic effects that could explain the discrepancy in the occurrence of these birth defects in the maternal vs. paternal lineage. We genotyped blood samples from 322 individuals from NTD-affected Irish families, identified through their membership in spina bifida associations. We looked for differences in distribution in maternal vs. paternal lineages of five genetic polymorphisms: the DHFR 19 bp deletion, MTHFD1 1958G>A, MTHFR 1298A>C, MTHFR 677C>T, and SLC19A1 80A>G. In addition to looking at genotypes ...

CHAPTER 25 METABOLIC ASPECTS OF FOLIC ACID AND COBALAMIN Williams Hematology CHAPTER 25 METABOLIC ASPECTS OF FOLIC ACID AND COBALAMIN BERNARD M. BABIOR Folic Acid Chemistry Nutrition Folate Physiology Assay Cobalamin Chemistry Nutrition Role Physiology Assay Chapter References Folate in its tetrahydro form is a transporter of one-carbon fragments, which it can carry at any…

Aim In order to reduce the risk of neural tube defects (NTDs) and iodine deficiency in pregnancy, the National Health and Medical Research Council recommends that pregnant women supplement their diet with folic acid and iodine. This study aimed to identify the knowledge, attitudes and practices of pregnant women regarding intake of these nutrients in order to assess whether women are adequately exposed to this health message. Methods One hundred and fifty-two conveniently sampled pregnant women residing in a regional area of New South Wales, Australia, completed a pretested questionnaire on knowledge and practices regarding nutritional supplement use during pregnancy and dietary sources of folic acid and iodine. Results Eighty-two per cent of women reported using supplements during their pregnancy, with the majority (67.7%) taking supplement brands containing both folic acid and iodine. Supplement use was significantly higher among women in the highest household income category (30.8 vs 69.2%; P = 0.001

ContextPrenatal folic acid supplements reduce the risk of neural tube defects and may have beneficial effects on other aspects of neurodevelopment.ObjectiveTo e

I was surprised to get a recent warning letter from the fda on nor an inhaled preparation of folic acid called Vitamin b12 plus tablets w folic acid. Animal reproduction toxicity studies have not been conducted with iv folic acid, and it is not known whether Tricon can cause some fetal harm when administered to a p