PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
Title: Macrophage-Derived Foam Cells in Atherosclerosis: Lessons from Murine Models and Implications for Therapy. VOLUME: 8 ISSUE: 12. Author(s):Nancy R. Webb and Kathryn J. Moore. Affiliation:Lipid Metabolism Unit, Massachusetts General Hospital, 55 Fruit St, GRJ1328, Boston, MA 02114,USA.. Keywords:Macrophage foam cell, modified lipoprotein, scavenger receptor, oxidation, secretory phospholipase A2. Abstract: Macrophage-derived foam cells play integral roles in all stages of atherosclerosis. These lipid-laden immune cells are present from the earliest discernable fatty-streak lesions to advanced plaques, and are key regulators of the pathologic behavior of plaques. This review summarizes the current understanding of the molecular mechanisms that regulate macrophage cholesterol uptake, foam cell formation, and lipid-driven pro-inflammatory responses that promote atherosclerosis. Specific emphasis will be placed on recent findings from mouse models of atherosclerosis regarding the pathways of ...
TY - JOUR. T1 - Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy. AU - Cui, Xinglong. AU - Kushiyama, Akifumi. AU - Yoneda, Masayasu. AU - Nakatsu, Yusuke. AU - Guo, Ying. AU - Zhang, Jun. AU - Ono, Haruya. AU - Kanna, Machi. AU - Sakoda, Hideyuki. AU - Ono, Hiraku. AU - Kikuchi, Takako. AU - Fujishiro, Midori. AU - Shiomi, Masashi. AU - Kamata, Hideaki. AU - Kurihara, Hiroki. AU - Kikuchi, Masatoshi. AU - Kawazu, Shoji. AU - Nishimura, Fusanori. AU - Asano, Tomoichiro. PY - 2010/1/1. Y1 - 2010/1/1. N2 - The differentiation of macrophages into cytokine-secreting foam cells plays a critical role in the development of diabetic angiopathy. J774.1, a murine macrophage cell line, reportedly differentiates into foam cells when incubated with oxidized LDL, ApoE-rich VLDL or WHHLMI (myocardial infarction-prone Watanabe heritable hyperlipidemic) rabbit serum. In this study, serum samples from Type 2 diabetic patients were added to the medium with J774.1 cells ...
Early atherogenesis is characterized by the accumulation of intimal foam cells, which are often thought to be derived from the inflowing blood monocytes that differentiate into macrophages. But intimal foam cells may also be derived from SMC. The studies reported in this article have focused exclusively on cultured primary murine SMC which become foam cells in response to enzyme-modified lipoproteins, such as ELDL. We suspect that these mechanisms may also be operative in vivo.. The contribution of SMC to foam cells of the atheromatous plaque has been subject of recent studies. Identification of lesional SMC-derived foam cell is problematic because lipid-loaded SMC assume aspects of macrophage-like cells. Even an excellent recent review did not seem to resolve this issue because of the difficulty of positively identifying the cell of origin of foam cells.53 However, with the markers, miRNA 143/145 and myocardin, Vengrenyuk et al13 were able to indicate that SMCs probably account for ≈40% of ...
Macrophage derived foam cells are a major constituent of the fatty deposits characterizing the disease atherosclerosis. Foam cells are formed when certain immune cells (macrophages) take on oxidized low density lipoproteins through failed phagocytosis. High density lipoproteins (HDL) are known to have a number of anti-atherogenic effects. One of these stems from their ability to remove excess cellular cholesterol for processing in the liver---a process called reverse cholesterol transport (RCT). HDL perform macrophage RCT by binding to forming foam cells and removing excess lipids by efflux transporters. |br| We propose a model of foam cell formation accounting for macrophage RCT. This model is presented as a system of non-linear ordinary differential equations. Motivated by experimental observations regarding time scales for oxidation of lipids and MRCT, we impose a quasi-steady state assumption and analyze the resulting systems of equations. We focus on the existence and stability of equilibrium
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Formation of foam cells by cholesterol accumulation in monocytes/macrophages is a primary step in the development of atherosclerotic lesions. Thus, the ability to inhibit cholesterol accumulation in macrophages or to remove CEs from mature foam cells in lesions would be of considerable therapeutic benefit. In macrophage foam cells, ACAT has been recognized to be responsible for CE synthesis. Furthermore, it has been proposed that whereas ACAT activity is regulated by the level of intracellular free cholesterol, the rate of CE hydrolysis remains unchanged under a variety of conditions.8 In addition, net hydrolysis of CEs obtained by inhibition of ACAT in peritoneal macrophages8 has provided a basis for designing therapeutic ACAT inhibitors to prevent cholesterol accumulation in macrophages.. It has been proposed that HSL is responsible for the nCEH activity in macrophage cell lines.9 10 In this report we present further evidence that HSL is present and accounts for essentially all of the nCEH ...
Aims: MicroRNAs (miRNAs) play key roles in inflammatory responses of macrophages. However, the function of miRNAs in macrophage-derived foam cell formation is unclear. Here, we investigated the role of miRNAs in macrophage-derived foam cell formation and atherosclerotic development.. Methods and Results: Using quantitative reverse transcription-PCR (qRT-PCR), we found that level of miR-155 expression was increased significantly in both plasma and macrophages from atherosclerosis (ApoE-/-) mice. We identified that oxidized LDL (oxLDL) induced the expression and release of miR-155 in macrophages, and that miR-155 was required to mediate oxLDL-induced lipid uptake and reactive oxygen species (ROS) production of macrophages. Further, ectopic overexpression and knockdown experiments identified that HMG box-transcription protein1 (HBP1) is a novel target of miR-155. Knockdown of HBP1 enhanced lipid uptake and ROS production in oxLDL-stimulated macrophages, and overexpression of HBP1 repressed these ...
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Foam cells are the fat-laden M2 macrophages that serve as the hallmark of early stage atherosclerotic lesion formation. They are an indication of plaque build-up, or atherosclerosis, which is commonly associated with increased risk of heart attack and stroke as a result of arterial narrowing and hardening. Foam cell formation is triggered by a number of factors including the uncontrolled uptake of modified low density lipoproteins (LDL), the upregulation of cholesterol esterification and the impairment of mechanisms associated with cholesterol release. Foam cells are formed when circulating monocyte-derived cells are recruited to the atherosclerotic lesion site or fat deposits in the blood vessel walls. Recruitment is facilitated by the molecules P-selectin and E-selectin, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Monocytes are then able to penetrate the arterial wall as a result of impaired endothelial integrity which increases permeability. Once ...
Methods and Results Tregs were isolated by magnetic cell sorting-column and analysed by fl ow cytometry. Macrophages were cultured with or without Tregs in the presence of oxidised LDL (oxLDL) for 48 h to transform foam cells. After co-culture with Tregs, macrophages showed a decrease in lipid accumulation, which was accompanied by a significantly downregulated expression of CD36 and SRA but no obvious difference in ABCA1 expression.. ...
TY - JOUR. T1 - Lipopolysaccharide stimulation of RAW 264.7 macrophages induces lipid accumulation and foam cell formation. AU - Funk, Janet L.. AU - Feingold, Kenneth R.. AU - Moser, Arthur H.. AU - Grunfeld, Carl. PY - 1993/1/4. Y1 - 1993/1/4. N2 - A role for immune and inflammatory processes in the induction of atherosclerotic lesions is emerging. These studies were undertaken to determine whether activation by lipopolysaccharide (LPS) enhances the ability of macrophages to become foam cells. Since LPS activation inhibits scavenger receptor activity, we studied the ability of LPS-activated RAW 264.7 macrophages to accumulate lipid from a variety of lipid particles that are not ligands for the scavenger receptor. Macrophages activated by LPS, in the absence of lipid particles, accumulated triglyceride, but not cholesterol ester (CE). The addition of Soyacal, a triglyceride-rich particle, further enhanced this LPS-stimulated triglyceride accumulation. LPS activation similarly enhanced CE ...
Anti-apoptotic Bcl-2 family member myeloid cell leukemia 1 (Mcl-1) plays an important, in neutrophils essential, role in promoting survival and differentiation of leukocyte subsets. Mcl-1 was shown to be responsible for IL-10 dependent inhibition of macrophage apoptosis in response to oxidized LDL in vitro. In this study we have investigated the role of myeloid Mcl-1 deficiency in atherosclerotic plaque development and stability. LDLr−/− mice were lethally irradiated and transplanted with bone marrow from transgenic mice with myeloid specific Mcl-1 deficiency (Mcl-1−/−) or WT littermates. After a recovery period of 8 weeks, the mice were fed a high-fat diet for 10 weeks to induce atherosclerotic lesion development in the aortic root. Peritoneal leukocytes were analyzed for foam cell numbers and sensitivity towards Ox-LDL. The number of foam cells among the resting peritoneal leukocyte population showed a 2,5 fold (p=0.02) increase in Mcl-1−/− mice compared to WT controls. After ...
Accumulation of lipid-laden macrophages is a hallmark of atherosclerosis. The relevance of the key transcription factor nuclear factor κB (NF-κB) for macrophage-derived foam-cell formation has not been unequivocally resolved. Transgenic mice lines were generated in which NF-κB activation is specifically inhibited in macrophages by overexpressing a trans-dominant, non-degradable form of IκBα (IκBα (32A/36A)) under control of the macrophage-specific SR-A promoter. Alanine substitution of serines 32 and 36 prevents degradation and retains the inactive NF-κB/IκBα (32A/36A) complex in the cytoplasm. Similarly, stable human THP1 monocytic cell lines were generated with integrated copies of IκBα (32A/36A) cDNA. Upon treatment with oxidized low-density lipoprotein (ox-LDL), murine peritoneal macrophages from transgenic IκBα (32A/36A) mice, as well as THP1/IκBα (32A/36A) clones, display decreased lipid loading after differentiation into macrophages. This is accompanied by increased ...
Description: Macrophage-derived foam cells play a predominant role in the deposition of arterial plaques during the early stages of atherosclerosis. The deposition of arterial plaques is known to be effected by several factors, including a persons dietary habits. The consumption of a high-fat (,60% of calories from fat) meal is known to elevate serum LDL and triglycerides, which have been previously implicated in the formation pf foam cells. One limitation of current research models is that it is not possible to directly measure foam cells in vivo. Thus, the purpose of the present study was to validate the use of blood derived monocytes as a proxy measure of foam cells. In order to complete this objective, we evaluated monocyte oxLDL phagocytosis capacity following consumption of a high-fat meal. Eight men and women participated in the present study and venous blood samples were collected prior to the meal, 1-h, 3-h, and 5-h post-meal. Monocytes (CD14+/16- and CD14+/16+) were evaluated for ...
Description: Macrophage-derived foam cells play a predominant role in the deposition of arterial plaques during the early stages of atherosclerosis. The deposition of arterial plaques is known to be effected by several factors, including a persons dietary habits. The consumption of a high-fat (,60% of calories from fat) meal is known to elevate serum LDL and triglycerides, which have been previously implicated in the formation pf foam cells. One limitation of current research models is that it is not possible to directly measure foam cells in vivo. Thus, the purpose of the present study was to validate the use of blood derived monocytes as a proxy measure of foam cells. In order to complete this objective, we evaluated monocyte oxLDL phagocytosis capacity following consumption of a high-fat meal. Eight men and women participated in the present study and venous blood samples were collected prior to the meal, 1-h, 3-h, and 5-h post-meal. Monocytes (CD14+/16- and CD14+/16+) were evaluated for ...
Figure 1: From left to right, AR-AFFF, AFFF, and protein foam.. Fluoroprotein. Fluoroprotein foams are protein foams that also contain fluorochemicals for vapor suppression and reduced fuel pick up when applied to non-polar flammable liquids. These foams will appear a very dark brown color and will have a distinct odor.. Film Forming Fluoroprotein (FFFP). Fluoroprotein foams are protein foams that also contain fluorochemicals for vapor suppression. However, what sets these apart from regular fluorproteins is that the fluorochemical surfactants are generally used at a higher concentration than standard fluoroprotein foam, giving these solutions the ability to form a vapor sealing film on non-polar solvents in a way similar to AFFFs. FFFPs are for use on non-polar flammable liquids. These foams will appear a very dark brown color and will have a distinct odor. The difference between a regular protein and a FFFP can be determined at Dyne. If the lab results show that the foam will form a film, the ...
Solid foams are a class of lightweight cellular engineering materials. These foams are typically classified into two types based on their pore structure: open-cell-structured foams (also known as reticulated foams) and closed-cell foams. At high enough cell resolutions, any type can be treated as continuous or "continuum" materials and are referred to as cellular solids,[14] with predictable mechanical properties. Open-cell-structured foams contain pores that are connected to each other and form an interconnected network that is relatively soft. Open-cell foams fill with whatever gas surrounds them. If filled with air, a relatively good insulator results, but, if the open cells fill with water, insulation properties would be reduced. Recent studies have put the focus on studying the properties of open-cell foams as an insulator material. Wheat gluten/TEOS bio-foams have been produced, showing similar insulator properties as for those foams obtained from oil-based resources.[15][16] Foam rubber ...
Memory foam was developed in 1966 under a contract by NASAs Ames Research Center to improve the safety of aircraft cushions. The temperature-sensitive memory foam was initially referred to as "slow spring back foam"; Most called it "temper foam".[2] Created by feeding gas into a polymer matrix, the foam has an open-cell solid structure that matches pressure against it, yet slowly springs back to its original shape.[3] Later commercialisation of the foam included use in both medical equipment such as X-ray table pads and sports equipment such as American / Canadian football helmet liners. When NASA released memory foam to the public domain in the early 1980s, Fagerdala World Foams was one of the few companies willing to work with the foam, as the manufacturing process remained difficult and unreliable. Their 1991 product, the "Tempur-Pedic Swedish Mattress" eventually led to the mattress and cushion company, Tempur World. Memory foam was subsequently used in medical settings. For example, it was ...
The results of this study show that the mitogenic effects of glucose-oxidized LDL are mediated primarily through CD36. Similarly, the ability of Cu2+-oxidized LDL to induce foam-cell formation was mainly dependent on CD36, consistent with a previous study that used macrophages from CD36- and SR-A-deficient mice (36). Recognition of oxidized LDL by macrophage scavenger receptors seems to be mediated by both the modified protein and lipid moieties (37,38). It is unclear whether the mitogenic effects are due to oxidized apolipoprotein B100 or to lipid oxidation products (9,18,19,39). In preliminary experiments, we found that neither the protein fraction nor the lipid fraction isolated from glucose-oxidized LDL increased DNA synthesis by macrophages (data not shown). These results suggest that combination of the lipid and the protein components may be essential to induce the mitogenic effect of glucose-oxidized LDL. One potential mechanism would involve binding of the protein component of ...
Memory foam cushions have actually wound up being fairly regular nowadays. A .com memory foam cushion varies from various other normal foam cushions around. Their growth began with the USA room program, among various other points. It arises from study done by NASA that became part of the advancement of the memory foam cushion.. NASA initially developed the memory foam to help astronauts to deal up with the high stress that could be caused by extreme G-force that takes place when the space capsule bus eliminate for area. It has actually not been used for the room program, the study and also explorations that were constructed from the memory foam had the ability to help supply benefits in the clinical area instead.. Memory foam is created from polyurethane incorporates wit included chemicals to add to the foams thickness degree. This will certainly improve the foams thickness. When cozy, the chemicals made use of on the polyurethane similarly allow it to wind up being stronger in cooler ...
Manufacturing with Foam Cores Material Preparation: When using foam cores in manufacturing, there are some strict guidelines that must be followed to produce a mechanically sound part. The foam materials must be stored and prepared correctly, or else the bonds will be highly suspect. First of all, the foam must be stored in a clean dry place. Any dust or moisture allowed to settle on the core may produce a disbond after laminating. If dust is present on the foam surface remove with a vacuum, or at worst blow it off with an air nozzle (with a DRY air source). Do not use solvent to wipe the surface; this only spreads the dust/contaminants around the foam surface and into the open surface cells. A strong solvent, such as acetone, might also degrade the foam on the surface, leaving a weak core/skin bond. With a properly clean surface, little else can go wrong when bonding on the skins. Processing with FRP: Foam cores can be used in almost all forms of fiberglass/advanced composite fabrication. The ...
Foam Fractionation - The Effect of Salts and Low Molecular Weight Organics on ABS Removal ASHIS K. SENGUPTA, Research Associate W. O. PIPES, Associate Professor of Civil Engineering The Technological Institute Northwestern University Evanston, Illinois INTRODUCTION Foam fractionation is a process by which a solution containing a surface active solute is separated into two fractions, the foam fraction which has a higher concentration of the surface active solute than the original solution and a drain fraction depleted of surface active material. The method of effecting the separation is to cause a foam to be produced by vigorous aeration and then to separate the foam from the bulk of the solution by mechanical means. When the foam is initially produced, the surface active solute is preferentially absorbed on the air water interfaces of the bubbles and thus the foam is richer in surface active material than the residual bulk solution. If some of the water held by the foam is allowed to drain back ...
MDI-based prepolymers are blown with a substantially nonaqueous blowing agent, such as pressurized air, and polymerized with stoichiometric amounts of polyoxyethylene polyol having at least two hydroxyl equivalents per mole, yielding a hydrophilic foam. The present foams may be extruded, knife-coated or otherwise cast into sheets, or may be fabricated by other known foam preparation techniques. Because the foam is polymerized with polyoxyethylene polyol instead of water, the foam exhibits both superior drape and improved stretch and recovery as compared with prior-art MDI-based flexible foams formed with aqueous reactants. The foam is particularly suited for use in external biomedical applications as, for example, a laminated medical/surgical dressing in which a thin sheet of the hydrophilic foam adheres to a nonstick aluminized veil on one side.
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Accumulation of foam cells containing cholesterol in arterial intima is a key event in the early stages of atherosclerosis (Paulson et al., 2010). Exposure to TLR agonists such as LPS or CpG oligodeoxynucleotide converts macrophages into foam cells (Kalayoglu and Byrne, 1998). There are various types of essential factors that contribute to foam cell formation. Among them, scavenger receptors that uptake modified lipoproteins are known to be critical (Badimón et al., 2009). TLRs directly cause inflammatory responses and induce the expression of specific scavenger receptors, such as lectin-like oxidized low density lipoprotein receptor 1 (Lee et al., 2008b). Although it is clear that PKC-PLD signaling participates in mechanisms that increase atherosclerosis, few research studies have addressed the function of RGS2 and the PKC-PLD pathway in the development of atherosclerosis.. The present results demonstrate that the PKC-η-PLD2 signaling pathway decreases LPS-induced RSG2 expression, thereby ...
Regulation of foam cells by adenosine.: Macrophages rely on reverse cholesterol transport mechanisms to rid themselves of excess cholesterol. By reducing accumu
The formation of an atherosclerotic lesion is mediated by lipid-laden macrophages (foam cells), which also establish chronic inflammation associated with lesion progression. The peroxisome proliferator-activated receptor (PPAR) gamma promotes lipid uptake and efflux in these atherogenic cells. In contrast, we found that the closely related receptor PPARdelta controls the inflammatory status of the macrophage. Deletion of PPARdelta from foam cells increased the availability of inflammatory suppressors, which in turn reduced atherosclerotic lesion area by more than 50%. We propose an unconventional ligand-dependent transcriptional pathway in which PPARdelta controls an inflammatory switch through its association and disassociation with transcriptional repressors. PPARdelta and its ligands may thus serve as therapeutic targets to attenuate inflammation and slow the progression of atherosclerosis ...
2) Regulation of VSMC foam cell development Atherosclerosis is considered a cholesterol storage disorder characterized by the accumulation of cholesterol in the arterial wall leading to lumen narrowing due to plaque growth and thereby increasing the risk for myocardial infarction or stroke. Atherosclerotic plaques consist to a large extent of lipid-laden foam cells. In recent years, it has been discovered that these cells are mainly derived from vascular smooth muscle cells (VSMCs). While a considerable amount of proteins have been identified to regulate the VSMC phenotype, significantly less is known about the control of VSMC foam cell formation. The thickening of the vessel wall, as it occurs in arteriosclerosis or vessel injury, is caused by active, proliferating and migrating medial VSMCs in the intima layer which was identified as an important determinant of atherosclerotic plaque formation. To achieve this, the activity of transcription factors controlling the VSMC activation ...
The invention relates to foam structures with enhanced physical properties which can be used in the areas of packaging, athletics, water sports, and construction. In general, the structures are laminated polymer foams that include a core of a low density foam and one or more skins of relatively high density foam covering the core. The skins provide improved physical properties to the foam structures by improving the flexural strength, resistance to bending, and resulting damage from bending in the laminated foam structure while modestly increasing the weight of the laminated structure, for example. Uses of the foam structures include, but are not limited to, packaging materials, gym mats, body boards, or eaves fillers. The skin can act as a hinge to fold a die cut piece into a collapsible packaging system.
Foams are under consideration for use in systems designed to absorb kinetic energy from projectiles. These systems are deployed to protect internal contents, people, precious objects, and other fragile items. Foams present an attractive option because they are light, simple and fast to form, and inexpensive. This work shows that foams are capable of absorbing kinetic energy from projectiles and will eventually arrest them. Though not immediately practical, this work with ideal foams opens up the way for future studies of projectile interaction with real foams. The initial work to characterize projectile interaction with bamboo, staircase, and oblique foams will contribute to the understanding of interaction with real foams ...
A method for foaming a liquid-based composition, such as a softening composition, onto a tissue is provided. The foam composition can be formed in a foam generator by combining the liquid-based composition and a gas, such as air. The foam composition has a blow ratio, i.e, ratio of air volume to liquid volume, greater than about 3:1. Moreover, the foam composition is also generally stable such that it has a half-life greater than about 3 minutes. In one embodiment, a tissue product having elevated regions and non-elevated regions can be foamed with a foam composition such that the elevated regions are applied with a greater amount of the foam composition than the non-elevated regions.
The network of channels in a dry foam (much more air than liquid) are the liquid layers in between polyhedral air bubbles. Along the edges of the polyhedra, there are thin "Plateau borders" or channels which meet at vertices of the polyhedra in volumes the authors call nodes. See Figure 1 for a diagram of one network unit. The researchers are actually interested in the flow through the channels and nodes, but rather than struggle to image very small channels, they decide to learn from bulk flow through the foam driven by gravity: "forced drainage." They introduce fluid to the top of a column of foam at a controlled rate ,math,Q,/math, and observe the front of wetter foam penetrate through the column of dry foam at velocity ,math,\nu_f,/math,. A quantity ,math,V_s,/math, is defined as the volumetric flow into the top of the tube divided by the cross-sectional area of the tube. The experimenters looked at three sizes of bubbles. The penetration speed ,math,\nu_f,/math, increases with ...
A method for generating a thermoplastic foam from an aqueous dispersion, the aqueous dispersion comprising a thermoplastic resin, water, and a dispersion stabilizing agent, the method including: adding at least one froth stabilizing surfactant to the aqueous dispersion to form a mixture; adding a fiber to the mixture; and frothing the mixture to create a froth, removing at least a portion of the water in the froth to create a foam, wherein the foam generated has a non-cellular fibrillated morphology. In another aspect, embodiments disclosed herein relate to a foam having a thermoplastic-based, fibrillated, non-cellular structure, wherein the foam has an average density of about 0.02 g/cm3 to about 0.07 g/cm3. In certain embodiments, the foam may be used in an absorbent article.
Saeed O, Otsuka F, Polavarapu R, Karmali V, Weiss D, Davis T, Rostad B, Pachura K, Adams L, Elliott J, Taylor R, Narula J, Kolodgie F, Virmani R, Hong CC**, Finn AV**. Pharmacologic suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2012; 32:299-307. **co-corresponding authors ...
Home » My Dog Is Throwing Up White Foam » Dog Vomiting White Foam, Foamy Mucus, Yellow Foam And Not Eating intended for My Dog Is Throwing Up White ...
This medicine is for external use only. Wash hands before and after use. Wash affected area and gently pat dry. Do not place the foam directly onto your hands or face. The warmth of your skin will cause the foam to melt. Place the desired amount directly into the cap or onto a cool surface. If the can feels warm or the foam seems runny, run the can under cold water. To apply, pick up small amounts of the foam with your fingertips and gently massage into the affected area(s) until the foam disappears. Apply as often as prescribed by your doctor or health care professional. Do not use this medicine near the eyes, nose, or mouth. If you do get any in your eyes rinse out with plenty of cool tap water. Use this medicine for the full course prescribed by your doctor or health care professional, even if you think your condition is better. Do not stop using except on your the advice of your doctor or health care professional.. Talk to your pediatrician regarding the use of this medicine in children. ...
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Described is a method of forming and curing high internal phase emulsions (HIPEs) into shaped three dimensional foam implements. In general the method uses the steps of: providing a HIPE, depositing the HIPE into a mold cavity having a predetermined three dimensional shape, curing the HIPE in the mold cavity to form a HIPE foam, and stripping the HIPE foam from the mold cavity to form the three dimensional foam implement. The molded implements are widely useful as components in absorbent articles, toys, insulation, and other uses where a combination of low density and tridimensional shape are desired.
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Muscle soreness, pain, and tightness often keep you from working out. Foam rolling helps heal and relax muscle tissue and eases trigger points. Unfortunately, for many people, rolling hurts," says Victor Viner, Mojis founder and CEO, in a media release.. "By adding heat, our Moji Heated Foam roller helps to relax and soothe muscles and makes foam rolling feel good. Plus, the therapeutic heat increases blood flow as you roll, which helps to tighten loose muscles even more. We made the bag so people wouldnt need to be near a microwave to benefit from heated foam rolling," he adds.. The bag is water resistant, lightweight, soft, and easy to clean, according to the company.. [Source(s): Moji, PR Newswire]. ...
A thermal regulating cushioning device includes a flexible, deformable outer membrane and a foam core contained therein having a dimension substantially coincident with the outer membrane. A liquid-like material is sealably contained within the outer membrane and saturates the foam core with the liquid-like material being at least partially circulatable through the foam core. The cooperation of the saturated foam core and the sealable flexible membrane provide a uniform, thermal regulating medium and structural support such that the cushioning device is readily, uniformly deformable when a load is applied thereto.
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Our Performance Memory Foam Pet Bed offers the optimal blend of body-conforming comfort and firm support, making it especially beneficial for heavier dogs and older pets with joint problems.4 layer of memory foam and 1 layer of orthopedic foam work together to evenly distributes your dogs body weight across the entire bed5 thick entry is ideal for senior or arthritic dogs Firm orthopedic foam core eliminates painful pressure pointsAll bed sizes support approximately 300 lbs. 100% polyester cover boasts a soft quilted top Removable cover is machine washable Measure your dogs length and girth for an accurate fitPersonalize with your dogs name (up to 10 characters)Neutral caramel color coordinates with any decorPlease note: Personalized items are non-returnable.
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Foam Chlor 50 is a self-foaming chlorinated alkali cleaner designed for use through a mechanical foaming device. The foaming properties of Foam Chlor 50 allows operators to visually see where the product has and has not been applied. In addition to used as a spray cleaner, Foam Chlor 50 can also be used as a soak for detachable equipment parts as well as COP cleaning. Foam Chlor 50 is approved for use in food plants by the USDA, uses only food-grade chemicals allowed by the FDA, and is Kosher certified. ...