Background & Aims : GB virus-C/hepatitis G virus GBV-C/HGV is a newly identified flavivirus, and little is known about its clinical significance. GBV-C/HGV was investigated in different populations, and its coinfection was investigated in patients with liver disease in Taiwan where hepatitis B and C are endemic. Methods : Viral RNA was studied...
Evidence indicates that the GBV-C or hepatitis G virus can cause persistent infection in humans, but little is known on the importance of vertical transmission. To assess the risk of mother-to-infant transmission and the clinical outcome of infected babies, we investigated 175 anti-HCV positive mothers and followed-up their children for 3-33 months. GBV-C RNA was detected by RT-PCR and anti-E2 antibody was assayed by EIA. Thirty-four (19.4%) women were GBV-C RNA positive and transmission occurred to 21 (61.8%) babies; 20 (95.2%) acquired GBV-C alone, and one (4.8%) GBV-C and HCV. Maternal factors such as intravenous drug use, HIV coinfection, HCV-RNA positivity, and type of feeding were not correlated with GBV-C transmission. GBV-C RNA remained persistently positive in all infected babies but one baby who seroconverted to anti-E2. Seven (35%) babies with GBV-C alone developed marginally elevated ALT; the baby with HCV and GBV-C co-infection had the highest ALT peak value (664 IU/l). Seven of the ...
Adams, N. J., Prescott, L. E., Jarvis, L. M., Lewis, J. C., McClure, M. O., Smith, D. B. & Simmonds, P. (1998). Detection in chimpanzees of a novel flavivirus related to GB virus-C/hepatitis G virus. J Gen Virol 79 ( Pt 8), 1871-1877. [PMID 9714234]. Agnello, V., Abel, G., Elfahal, M., Knight, G. B. & Zhang, Q. X. (1999). Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci U S A 96, 12766-12771. [PMID 10535997]. Baechlein, C., Fischer, N., Grundhoff, A., Alawi, M., Indenbirken, D., Postel, A., Baron, A. L., Offinger, J., Becker, K., Beineke, A., Rehage, J. & Becher, P. (2015). Identification of a Novel Hepacivirus in Domestic Cattle from Germany. J Virol 89, 7007-7015. [PMID 25926652]. Bukh, J., Kim, J. P., Govindarajan, S., Apgar, C. L., Foung, S. K., Wages, J., Jr., Yun, A. J., Shapiro, M., Emerson, S. U. & Purcell, R. H. (1998). Experimental infection of chimpanzees with hepatitis G virus and genetic analysis of the virus. J ...
Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is composed of fast evolving RNA viruses that infects vertebrate (mammals and birds) and/or invertebrate (ticks and mosquitoes) organisms. These host groups are very distinct life forms separated by a long evolutionary time, so lineage-specific anti-viral mechanisms are likely to have evolved. Flaviviridae viruses which infect a single host lineage would be subjected to specific host-induced pressures and, therefore, selected by them. In this work we compare the genomic evolutionary patterns of Flaviviridae viruses and their hosts in an attempt to uncover coevolutionary processes inducing common features in such disparate groups. Especially, we have analyzed dinucleotide and codon usage patterns in the coding regions of vertebrate and invertebrate organisms as well as in Flaviviridae viruses which specifically infect one or both host types. ...
Abbas, Y. M., Pichlmair, A., Gorna, M. W., Superti-Furga, G. & Nagar, B. (2013). Structural basis for viral 5-PPP-RNA recognition by human IFIT proteins. Nature 494, 60-64. [PubMed]. Adams, N. J., Prescott, L. E., Jarvis, L. M., Lewis, J. C., McClure, M. O., Smith, D. B. & Simmonds, P. (1998). Detection in chimpanzees of a novel flavivirus related to GB virus-C/hepatitis G virus. J Gen Virol 79 ( Pt 8), 1871-1877. [PubMed]. Baechlein, C., Fischer, N., Grundhoff, A., Alawi, M., Indenbirken, D., Postel, A., Baron, A. L., Offinger, J., Becker, K., Beineke, A., Rehage, J. & Becher, P. (2015). Identification of a Novel Hepacivirus in Domestic Cattle from Germany. J Virol 89, 7007-7015. [PubMed]. Baechlein, C., Grundhoff, A., Fischer, N., Alawi, M., Hoeltig, D., Waldmann, K. H. & Becher, P. (2016). Pegivirus Infection in Domestic Pigs, Germany. Emerging Infect Dis 22, 1312-1314. [PubMed]. Bailey, A. L., Lauck, M., Ghai, R. R., Nelson, C. W., Heimbruch, K., Hughes, A. L., Goldberg, T. L., Kuhn, J. H., ...
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of "NTU Repository" with "Academic Hub" to form NTU Scholars.. ...
What can I take for chronic muscle pain? 75 yr. Old. Hep C for 20-30 yr. Family Doctor tells me to take Tylenol..dont take it as condition is chronic & severe. Cant sleep due to it.
Just curious about the possibility of getting Hep C from my partner while having sex, oral, or just kissing? What are the risks, and what precautions if any should we be taking. Is abstinence the answe...
Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: ##STR00001## wherein, Y, W, W.sup.1 and W.sup.2 are as defined herein.
in Acta Gastro-Enterologica Belgica (1999), 62(1), 13-15. Background : Recently, a novel blood-borne virus has been identified and named hepatitis G virus. Transfusion is the main route of transmission. It is known that patients on maintenance dialysis are more ... [more ▼]. Background : Recently, a novel blood-borne virus has been identified and named hepatitis G virus. Transfusion is the main route of transmission. It is known that patients on maintenance dialysis are more susceptible to infections with parenterally-transmitted viruses than the general population. The aim of the present study was to determine the prevalence of hepatitis G infection in a Belgian dialysis unit. Methods: The entire population of our dialysis unit (82 patients) was tested for the presence of hepatitis G virus (HGV) by reverse transcriptase polymerase chain reaction. History of transfusion or renal transplantation coinfections with hepatitis B and C viruses, and serum aminotransferase levels were also tested. ...
Hepatitis G is a newly discovered form of liver inflammation caused by hepatitis G virus (HGV), believed to be a distant relative of the hepatitis C virus. HGV, also called hepatitis GB virus, was first described early in 1996. Little is known about the frequency of HGV infection, the nature of the illness, or how to prevent it. What is known is that transfused blood containing HGV has caused some cases of hepatitis. For this reason, patients who require large amounts of blood or blood products are at risk of hepatitis G. Often patients with hepatitis G are infected at the same time by the hepatitis B or C virus, or both. In about three of every thousand patients with acute viral hepatitis, HGV is the only virus present. There is some indication that patients with hepatitis G may continue to carry the virus in their blood for many years, and so might be a source of infection in others ...
Blood-borne hepatitis is a well-known complication in patients with bleeding disorders. A recently discovered parentally transmitted virus, hepatitis G [GB virus C (GBV-C)] has an increased prevalence in patients with haemophilia. Clotting factor concentrates derived from pools of human plasma currently undergo viral inactivation techniques known to be effective against hepatitis B, C and HIV; however, the effectiveness of current purification and viral inactivation techniques against newly discovered viruses such as GBV-C is unknown. A total of 37 vials of clotting factor concentrates manufactured in the USA from 1981 to 1995 were tested for the presence of GBV-C virus. All samples that did not undergo a specific viral inactivation step were positive for GBV-C. Viral inactivation techniques that did not uniformly remove GBV-C included vapour heat treatment and dry heat treatments for less than 144 h. All samples treated by pasteurization, solvent detergent or dry heat for 144 h, were negative for the
One year later, after a reform of the education programme, another group of first-year students were tested what is tadalafil used for (212 girls and 117 boys) in the same schools. We determined by sonography the prevoiding bladder volume needed to void a sufficient amount of urine.. Evaluation of the identification power of RPLC analyses in the screening for drug compounds. A second post-processing requirement is the frequency axis assignment. Detection of tadalafila 5mg hepatitis G virus RNA in persons with and without known risk factors for blood-borne viral infections in Sweden and Honduras. However, some events appeared to be predictors of patient admission rates. To explore the feasibility of using social media-based patient networks to gather qualitative data on patient-reported outcome (PRO) concepts tadalafil dosage relevant to chronic lymphocytic leukemia (CLL). Implementation of pattern-mixture models in randomized clinical trials. An estrogen receptor mutant tadalafil kopen nederland ...
Background: GB virus C (GBV-C) or hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle which has not yet been proven to have major negative effects on liver. Army hospitals in Tehran were included. Serum HIV antibody (Ab) HCV antibody and HBS antigen (Ag) were assessed. Demographic data such as gender age blood group cause of renal failure dialysis onset and duration were collected from medical files. GBV-C/HGV was evaluated by nested reverse transcription polymerase chain reaction (RT-PCR) method. Then all data were analyzed by SPSS ver. 13. Etomoxir Results: In total 81 males and 57 females were included. The mean age of patients was 62.16 ± 14.86 years. Six (4.3%) had positive results for GBV-C/HGV by RT-PCR. Except gender (P = 0.045) and duration of dialysis in a week (P < 0.001) other demographic factors revealed no significant difference (P > 0.05). All patients had negative results for HIV Ab HCV Ab and HBS Ag. Conclusions: Overall ...
Results show non-pathogenic E1 GB virus C protein as an attractive source of peptides for development of novel anti-HIV therapies- Global Medical Discovery
Results: Combined GBV-C RNA and anti-E2 prevalances ranged from 6.5% in children, 13.3% in blood donors, 14% in pregnant women, 22.5% in haemodialysis patients, 80% in anti-HCV positive donors and 88.6% in IVDUs and 85.7% in adult haemophiliacs. Children had the lowest antibody rate, 1.1%, compared with 10.8% for blood donors rising to 45.7% for IVDUs and to 74.6% for haemophiliacs. In contrast current infection rates were comparable for children, blood donors and pregnant women at 5.4%, 2.6% and 6%. These rates rose to 11.1% for haemophiliacs, 24.3% for anti-HCV donors and 48.6% for IVDUs. Ten of 12 donors had persistent vireamia while two had recent infections, one with apparent resolution. 47% of donors who had lived in the Pacific Islands had GBV-C exposure compared to 16% who had not lived in the Pacific. (P,0.01). Spending evening outdoors was also associated with HGB exposure ...
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Ive decided to start posting abstracts and links to papers that I find interesting. Todays topic: GB virus C.. GBV-C is a non-pathogenic virus that infects humans. This 2014 paper details the impact of co-infection with HIV-1. Ultimately they conclude that GBV-C co-infection may be beneficial to HIV-1 patients. However, the benefits of GBV-C are not apparent when patients are treated with anti-retroviral therapy.. Impact of GB virus C viraemia on clinical outcome in HIV-1-infected patients: a 20-year follow-up study.. D Ernst, M Greer, R Akmatova, S Pischke, H Wedemeyer, H Heiken, HL Tillmann, RE Schmidt and M Stoll. HIV Medicine v. 15 p. 245-250. ...
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Medical definition of Flaviviridae: a family of single-stranded RNA viruses that have a spherical virion with a capsid composed of a single protein…
Study Flashcards On M2-C3-L93 --| Flaviviridae, Togaviridae, Bunyaviridae at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Odolaren bidez birusa gibelera iristen da eta bertan hepatozitoak kaltetzen ditu. Infektatuen gehiengoak hasieran ez du inongo sintomarik. Birusaren eramaileak dira eta odolaren bidez beste pertsona batzuk kutsa ditzakete, baina asintomatikoak daudenez ez dira arrisku horretaz ohartzen. Infektatutako gizabanako gutxi batzuek nekea, goragaleak, pisu-galera eta ikteriziarik gabeko hepatitisaren ohiko sintomak ere dituzte [4] baina -esan bezala- gehienek ez dute inongo sintomarik garatzen. Azken hauengan gaitza antzematen da odol-analisi arrunt batean (transaminasak eta beste entzima hepatikoen balioak aztertuz). Gaixo gutxi batzuen immunitate-sistemak birusa deuseztatzen du, baina infektatuen %80ak hepatitis kronikoa garatuko du. Birusak urte askotan gibela kaltetzen du, eta epe aldakor batean (10-30 urte) zirrosia eta gibeleko minbizia eragin dezake. Gibela oso kaltetuta dagoenean, sintomak nabariagoak dira: nekea, sukarra, goragaleak, ikterizia, sabelmina.... Gaitzaren progresio-erritmoa adina, ...
|strong|Rabbit anti West Nile Virus antibody|/strong| recognizes the ~14 kDa core protein of West Nile Virus (WNV). WNV belongs to the Flaviviridae family which includes closely viruses such as D…
Chang K.-C; Chang M.-H; Lee C.-N; Chang C.-H; Wu J.-F; Ni Y.-H; Wen W.-H; MING-KWANG SHYU ; Lai M.-W; Chen S.-M; Hu J.-J; Lin H.H; Hsu J.-J; Mu S.-C; Lin Y.-C; Liu C.-J; Chen D.-S; Lin L.-H; Chen H.-L; Hwa H.-L; Su Y.-N; Shih J.-C; Chao K.-H; Hsu H.-Y; Chiu Y.-C; Su T.-H; Lin C.-C; Lin P.-Y; Yang W.-R; Zhao L.-L; Yang C.-K; Chang Y.-K; Chen K.-H; Lin Y.-H; Chen H.-J; Pan H.-S; Lau B.-H; Lee C.-L; Cheng P.-J; Chang Y.-L; Chiueh H.-Y; Wang T.-H; Lo L.-M; Hsieh C.-L; Cheng S.-W; Tsai M.-S; She B.-Q; Koh K.-J; Hung Y.-L; Lin H.-M; Peng F.-S; Wu T.-C; Chen C.-Y; Chen C.-P; Huang J.-P; Yeung C.-Y; Lin C.-J; Chiu W.-T; Wang D.-S; Lin W.-T; Hwang K.-S; Huang C.-F; The Taiwan Study Group for the Prevention of Mother-to-Infant Transmission of HBV (PreMIT study) ...
A brand new and ever more powerful strain of the Virus was released in 2002 to replace the entire B Series line-up. First up is the flag-ship desktop module, the Virus C. Polyphony is expanded from 24 to 32 voices! Otherwise the synth engine is virtually the same as the B series. Three oscillators, one sub osc., two independent multi-mode filters, two ADSTR envelopes, three LFOs, 16 arpeggiators, 32-band vocoder, five FM synthesis modes and 16 part multitimbrality. The C series offers an expanded mod matrix with 6 source and 9 destination slots, 98 effects, wood side panels, and more! A new 3-band EQ section is available as well as an Undo/Redo function. The operating systems can be easily upgraded via MIDI and there is a free SoundDiver Virus editor/librarian for Windows and MacOS systems available. It has been used by Nine Inch Nails, KMFDM, and Max Graham.. ...
357 Guillen-Nunez, E Deadlines Final Book WAIT LIST HLTH 91C Hepatitis ABCs 1.0 72848 001 Lec T 07:10-09:00PM 10/21-12/09 MUB ...
The purpose of this study is to examine the effect of GB virus C (GBV-C) on the natural history of chronic hepatitis C virus (HCV) infection in subjects co-infected with HIV and HCV. The other aspect of the study is to assess the effect of GBV-C on the severity of liver disease due to chronic hepatitis C in subjects co-infected with HIV and HCV. This will be done by determining the point prevalence of co-infection retrospectively then following that cohort prospectively. In addition, further individuals will be recruited in a prospective manner ...
The purpose of this study is to examine the effect of GB virus C (GBV-C) on the natural history of chronic hepatitis C virus (HCV) infection in subjects co-infected with HIV and HCV. The other aspect of the study is to assess the effect of GBV-C on the severity of liver disease due to chronic hepatitis C in subjects co-infected with HIV and HCV. This will be done by determining the point prevalence of co-infection retrospectively then following that cohort prospectively. In addition, further individuals will be recruited in a prospective manner ...
GB virus C (GBV-C), which is highly prevalent among HIV/AIDS, seemed to slow the HIV disease progression. The HIV/GBV-C co-infected individuals may represent an interesting model for the investigation of the role played by HIV infection and/or the immune system in driving the evolution of the GBV-C viral populations. The present study investigated the prevalence and population dynamics of GB virus C in HIV infected individuals representing 13 geographic regions of Hubei Province of China. Approximately 37% of HIV-1 infected individuals were infected with GBV-C and genotype 3 is appeared to be predominant. Utilizing the 196 complete E2 nucleotide sequence data from 10 HIV/GBV-C infected individuals and employing coalescence based phylogenetic approaches; the present study has investigated the intra-host dynamics of GBV-C. The results revealed patient-specific unique GBV-C viral lineages and each viral lineage showed the evidence of rapid population expansion in respective HIV-1 infected patients, thus
The sexual partners of men with hepatitis C virus (HCV) infection have a relatively low prevalence of the disease, yet cases of sexual transmission have been reported. With the discovery of a new HCV-related virus named hepatitis G (HGV) or GBV-C, the issue of sexual transmission has become more complicated. It is now recognized that HGV and GBV-C are two distinct isolates of the same virus, to be labeled HGV/GBV-C. Previous studies indicate that HGV/GBV-C infection may occur in up to 7 percent of the population and may infect up to 30 percent of persons at risk for bloodborne infections, such as intravenous drug users. Semprini and colleagues examined semen and serum samples from men infected with hepatitis C to determine whether HCV RNA and HGV/GBV-C RNA are present in semen.. The 90 men in the study were former intravenous drug users. All tested positive for anti-HCV antibodies. Of the group, 27 were also positive for human immunodeficiency virus (HIV) infection, and 10 were positive for ...
GB virus type C (GBV-C) is a common human flavivirus that has been associated with prolonged survival in HIV-positive individuals in several, though not all, epidemiological studies. There are five distinct GBV-C genotypes that are geographically localized, and it has been speculated that GBV-C genotypic differences may explain variable outcomes observed in different clinical studies. Expression of an 85 aa fragment of the GBV-C NS5A phosphoprotein (genotype 2) in a CD4+ T cell line (Jurkat) resulted in inhibition of HIV replication, mediated in part by decreased surface expression of the HIV coreceptor CXCR4 and upregulation of SDF-1. We expressed the NS5A protein from genotypes 1, 2, 3 and 5 in Jurkat cells, and demonstrated that all genotypes inhibited HIV replication. Further deletion mapping demonstrated that expression of a 30 aa fragment resulted in decreased CXCR4 surface expression, upregulation of SDF-1 and inhibition of HIV replication.
GB virus C (GBC) and HIV Co-infection: Researchers at the University of Iowa used ARRA funding to expand their ongoing research to better understand the apparent protective effect of GB virus C (GBV-C) infection on the progression of HIV in people coinfected with the two viruses. Co-infection with GBV-C, a virus that is not known to cause any disease, is common in HIV-infected individuals. The researchers found that GBV-C appears to inhibit specific immune signaling pathways and immune activation, which is a key process in HIV disease progression. In addition, the presence of GBV-C in the bloodstream was found to be associated with a reduction in programmed cell death of activated T-cells (a type of immune cell). These GBV-C-associated T-cell effects could contribute to the observed protective effect of GBV-C co-infection in HIV-infected individuals.4 ...
Journal of Shahid Sadoughi University of Medical Sciences ماهنامه علمی پژوهشی دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد
The Zika virus is a single stranded RNA virus of the Flaviviridae family transmitted primary by Aedes mosquitoes, although other modes of transmission are possible including mother-to-child, sexual and blood transfusions. The virus is usually self-limiting with symptoms similar to dengue and chikungunya, and work is on-going to establish a link between the virus and […]. [Read More] ...
Yellow fever is a mosquito borne disease caused by a virus from the Flaviviridae family, called the yellow fever virus. This virus is transmitted via female
Louping-ill Louping-ill is an acute viral disease of the central nervous system transmitted by sheep ticks (Ixodes ricinus). The disease can also spread via droplet infection. The disease is caused by a member of the Flaviviridae family. It is antigenically closely related (i.e.
The latest issue of the Annals of Internal Medicine investigates reducing the risk for mother-to-infant transmission of Hepatitis C virus.. ...
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Pregnancy in HIV-infected women. Counseling and care--12 years experiences and results.: Although it is possible to reduce mother-to-infant transmission by zid
Definition: Zika virus is a member of the virus family Flaviviridae and the genus Flavivirus, transmitted by daytime-active Aedes mosquitoes, such as A. aegypti
Prevalence studies have demonstrated a global distribution of equine hepacivirus (EqHV), a member of the family Flaviviridae. However, apart from a single case of vertical transmission, natural routes of EqHV transmission remain elusive. Many known flaviviruses are horizontally transmitted between hematophagous arthropods and vertebrate hosts. This study represents the first investigation of potential EqHV transmission by mosquitoes. More than 5000 mosquitoes were collected across Austria and analyzed for EqHV ribonucleic acid (RNA) by reverse transcription quantitative polymerase chain reaction (RT-qPCR). Concurrently, 386 serum samples from horses in eastern Austria were analyzed for EqHV-specific antibodies by luciferase immunoprecipitation system (LIPS) and for EqHV RNA by RT-qPCR. Additionally, liver-specific biochemistry parameters were compared between EqHV RNA-positive horses and EqHV RNA-negative horses. Phylogenetic analysis was conducted in comparison to previously published sequences ...
Dr. Nancy HaigwoodMother-to-child transmission of HIV remains a significant problem in the resource-poor world. Given appropriate prenatal care, and continuation of antiretroviral therapy (ART) for mother and infant during breastfeeding, over 99% of HIV-positive women can expect to deliver a baby free of HIV. But there are still more than 200,000 infected infants born annually to HIV-positive mothers in countries where prenatal care and ART are not readily available. In addition, potentially less toxic interventions, not reliant on strict medication adherence, would clearly be welcomed.. amfAR-funded scientist Dr. Nancy Haigwood and colleagues at Oregon Health and Science University and the National Institutes of Health approached this problem through a monkey model. They examined mother-to-child transmission of a hybrid AIDS virus known as SHIV, which contains elements of both HIV and the simian AIDS virus, SIV. Writing in the April issue of the prominent journal Nature Medicine, Dr. Haigwood ...
Viral RNA-dependent RNA Polymerase Assay. The Viral RNA-dependent RNA Polymerase Assay is developed using a RNA polymerase in the Flaviviridae,. a family of positive, single-stranded, enveloped RNA viruses. The assay is based on measurement of the. RNA molecules synthesized by the RNA polymerase using RNA as a template in the presence of NTPs.. The assay can be performed in a 384-well or 96-well plate format for tests of theenzyme activities of RNA. polymerases in the Flaviviridae family and high throughput screening of inhibitors. ...
PACTG according to the free Medical Dictionary. This is the preeminent organization in the world for evaluating treatments for HIV-infected children and adolescents, and for developing new approaches for the interruption of mother-to-infant transmission.
I like the look of Proviron from what I have read and am considering incorporating it into my next cycle. As an anti-e, does it stop the conversion in the first place like Arim or block it at the receptor like Nolva? If it stops the conversion, I guess like Arim it is no good against Deca and Tren which do that progesterone thing. If it blocks at the receptor then it will work against anything. If it works at the receptor and therefore against any AAS, why dont more people use it
All you need to know about Hepatitis C. LiverSupport.com looks at the signs and symptoms, as well as treatment options for Hepatitis C.
Hepatitis A You can avoid getting hepatitis A by getting the hepatitis A vaccine. Vaccines are medicines that keep you from getting sick. Vaccines tea
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