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RCTs reporting recruitment data in primary care suggest that once screened for eligibility and found to match inclusion criteria patients are likely to be randomized. This finding needs to be treated with caution as it may represent inadequate identification or reporting of the eligible population. …

Annual Mass Drug Administration (MDA) is one of the strategies used to combat Neglected Tropical Diseases (NTDs) such as trachoma, onchocerciasis, lymphatic filariasis, schistosomiasis, soil-transmitted helminthiasis (STH). NTDs affect more than a billion people around the world, mainly in developing countries, including Ethiopia.. The Supervisors Coverage Tool (SCT) is a rapid, simple, and inexpensive monitoring and supervising tool recently endorsed by the World Health Organization (WHO). The tool is generally implemented by a district or sub-district level supervisor prior to the end of an MDA round. The SCT can help detect issues related to poor compliance, the drug distribution strategy, and the performance of community drug distributors. The tool can also be used to identify districts in need of additional (mop-up) treatments.. The SCT was included and implemented nationally in Ethiopia in the 2017-2018 annual MDA rounds. The MDA in Benishangul-Gumuz, which was one of the regions where ...

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The administration of drugs to whole populations irrespective of disease status is referred to as mass drug administration (MDA). This article describes the administration of antimalarial drugs to whole populations an intervention which has been used as a malaria-control measure for more than 70 years. Recent proposals to eliminate or even to eradicate malaria have led to a renewed interest in mass drug administrations in areas with very high malaria endemicity. Drugs have been administered either directly as a full therapeutic course of treatment or indirectly through the fortification of salt. Mass drug administrations were generally unsuccessful in interrupting transmission but, in some cases, had a marked effect on parasite prevalence and on the incidence of clinical malaria. MDAs are likely to encourage the spread of drug-resistant parasites and so have only a limited role in malaria control. They may have a part to play in the management of epidemics and in the control of malaria in areas ...

To view the full list of upcoming clinics, please visit vaccine.howardcountymd.gov. Vaccine clinics will also be offered from August 7 - 14 at the Howard County Fair. A full schedule of vaccine clinics offered at upcoming Merriweather concerts is also available online. Residents in need of a second dose appointment can email the Howard County Health Department at [email protected]. Walk-up vaccine also available for those who previously missed their second dose appointment. The Health Department continues to offer a wide range of community vaccination clinics for any eligible individual who is not yet fully vaccinated, said Howard County Health Officer Dr. Maura Rossman. The extremely contagious Delta variant is now the dominant strain in our County, underlining the importance that everyone 12 and older get vaccinated to reduce the spread of this virus and protect those who are immunocompromised or not yet eligible to receive the vaccine. ...

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Since then, there have been numerous studies into ivermectin as a potential treatment for COVID-19. In late 2020, a research group in India was able to summarise the results of four small studies of ivermectin as an add-on treatment in COVID-19 patients. This review showed a statistically significant improvement in survival among patients who received ivermectin in addition to other treatments.. But the authors stated clearly that the quality of the evidence was low and that the findings should be treated with caution. As is frequently the case for reviews of multiple small studies, the paper suggested that further trials were needed to determine whether ivermectin was indeed clinically effective.. A controversy subsequently blew up over an article by the Front Line COVID-19 Critical Care Alliance, a group of doctors and researchers that lobbies for the use of ivermectin. This article, summarising multiple small studies of the effects of ivermectin on COVID-19 patients, was provisionally ...

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A statistical study was made of those officers who applied to separate under the Officer FY 73 Early Separation Program. The eligible population consisted of non-rated support officers with total active federal commissioned service dates (TAFCSD) of 1 July 1961 through 31 December 1970. Computer printouts from a mechanized UOR File were made on both the applicants and the eligibles. The officers were placed into fiscal year groups based on TAFCSD and classified according to characteristics of components, race, source of commission, education level, functional area of duty assignment, major air command of assignment, and active duty service commitment remaining to be fulfilled. (Author)(*AIR FORCE PERSONNEL

Background Glucosamine is commonly prescribed as a disease modulating agent in osteoarthritis. However, the evidence to date suggests that it has a limited impact on the clinical symptoms of the disease including joint pain, radiological progression, function and quality of life. The aim of this study was to examine the prescribing patterns of glucosamine from 2002-2011 in an elderly Irish national population cohort using data from the Health Service Executive Primary Care Reimbursement (HSE-PCRS) General medical services (GMS) Scheme. Methods Patients aged ≥ 70 years on the HSE-PCRS pharmacy claims database between January 2002 and December 2011 were included. ATC code M01AX05 (glucosamine) was extracted. Prevalence rates per 1000 eligible population with 95% confidence intervals were calculated for all years and age groups (70-74 years, ≥75 years). A negative binomial regression analysis was used to determine longitudinal usage trends and compare prevalence rates across years, sex and age ...

A motion being put forward by Cllr Rick Everitt and a meeting of Thanets full council on February 25 says: Thanet has the highest number of universal credit claimants in Kent - more than 18,000, nearly a quarter of the eligible population and an increase of almost two-thirds over the last year due to the impacts of COVID-19 on our local economy.. A third of these residents are in work, but recorded unemployment is up 80% since March 2020 and now afflicts one in ten of the working age population. One in eight Thanet households is in fuel poverty.. Last March, the chancellor announced a £20 per week uplift to universal credit and working tax credit for 2020/21. This has been a vital lifeline to thousands of families in Thanet and provided an eight-figure cash injection to their collective spending power, helping them feed their children, heat their homes and support local business.. It has helped contain the severe pressure on the voluntary sector, including local food banks. The estimated ...

About 9 million people in the United States are covered by both Medicare and Medicaid, including low-income seniors and younger people with disabilities. These dual eligible beneficiaries have complex and often costly health care needs, and have been the focus of many recent initiatives and proposals to improve the coordination of their care aimed at both raising the quality of their care while reducing its costs. This page highlights some key resources examining the dual eligible population and provides you with the standard search result page for a site-wide search on the dual eligible tag ...

About 9 million people in the United States are covered by both Medicare and Medicaid, including low-income seniors and younger people with disabilities. These dual eligible beneficiaries have complex and often costly health care needs, and have been the focus of many recent initiatives and proposals to improve the coordination of their care aimed at both raising the quality of their care while reducing its costs. This page highlights some key resources examining the dual eligible population and provides you with the standard search result page for a site-wide search on the dual eligible tag ...

Having immunized 70 per cent of its eligible population with at least one dose of COVID-19 vaccine, Alberta will lift public health restrictions in two weeks, Premier Jason Kenney announced Friday.

This reference guide summarizes a set of curated resources to help key stakeholders better understand both the needs of the dually eligible population and emerging evidence and practical approaches for advancing Medicare-Medicaid integration ...

This reference guide summarizes a set of curated resources to help key stakeholders better understand both the needs of the dually eligible population and emerging evidence and practical approaches for advancing Medicare-Medicaid integration ...

With Malta having already surpassed the 70% summer quota set by the EU, the Maltese government has set a new target and aims to have vaccinated 80% of the eligible population in the coming

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TY - JOUR. T1 - Accuracy of Coverage Survey Recall following an Integrated Mass Drug Administration for Lymphatic Filariasis, Schistosomiasis, and Soil-Transmitted Helminthiasis. AU - Budge, Philip J.. AU - Sognikin, Edmond. AU - Akosa, Amanda. AU - Mathieu, Els M.. AU - Deming, Michael. PY - 2016/1/14. Y1 - 2016/1/14. N2 - Background: Achieving target coverage levels for mass drug administration (MDA) is essential to elimination and control efforts for several neglected tropical diseases (NTD). To ensure program goals are met, coverage reported by drug distributors may be validated through household coverage surveys that rely on respondent recall. This is the first study to assess accuracy in such surveys. Methodology/Principal Findings: Recall accuracy was tested in a series of coverage surveys conducted at 1, 6, and 12 months after an integrated MDA in Togo during which three drugs (albendazole, ivermectin, and praziquantel) were distributed. Drug distribution was observed during the MDA to ...

The World Health Organization (WHO) Global Program to Eliminate Lymphatic Filariasis relies on mass drug administration (MDA) of two drugs annually for 4 to 6 years. The goal is to reduce the reservoir of microfilariae in the blood to a level insufficient to maintain transmission by the mosquito vector. In 2008, the international medical aid organization Médecins Sans Frontières (MSF) performed the first round of a MDA in the high-burden area of Asmat district, in Papua, Indonesia. We report the challenges faced in this MDA on a remote Indonesian island and propose solutions to overcome these hurdles in similar future contexts. During the MDA, we encountered difficult challenges in accessing as well as persuading the patient population to take the antifilarial drugs. Health promotion activities supporting treatment need to be adapted and repetitive, with adequate time and resources allocated for accessing and communicating with local, seminomadic populations. Distribution of bednets resulted in an

I am somewhat stunned when ethicists propose policies that discriminate against groups of people. The job of an ethicist is to hold society to a standard; to ensure that were comporting ourselves in a way that is just and humane. So I question when any ethicist, such as Cristina Richie, asks society to create policy that would target removing services from certain segments of the population. Such as… oh… I dont know… proposing that fertility treatment coverage be denied to those in the LGBT community or single mothers by choice.. Richie published a paper in the Journal of Medical Ethics this week and in the abstract stated, Second, I will recommend that policymakers eliminate funded ARTs for those who are not biologically infertile. Why does she believe that only those who have a documented medical reason for not being able to conceive should receive the state mandated coverage (she lives in Massachusetts) of their infertility treatments?. Because she wants to create an incentive for ...

In this Cochrane Review, Cochrane researchers examined the effects of using albendazole alone and albendazole added to antifilarial drugs to treat infected people and people who live in areas with lymphatic filariasis. After searching for relevant trials up to January 2018, we included 13 randomized controlled trials (RCTs), including one cluster‐RCT, with a total of 8713

We have followed a population in an area endemic for Brugia malayi for three years after intensive treatment with diethylcarbamazine (DEC). Microfilariae were cleared from the circulation within four months in all eligible study participants (n = 60). There appeared to be a strong correlation between the maximum reduction in specific IgG4 and the number of days drug was taken under supervision (ρ = 0.41, P < 0.001), indicating that high total dosage of DEC is necessary for optimal reduction of active infection. In individuals with good compliance (at least 180 mg/kg of body weight, n = 34), we observed variable IgG4 patterns. All pre-treatment IgG4+ children (9-14 years old) and 40% of the IgG4+ adult population (≥ 15 years old) showed a gradual decrease in anti-filarial IgG4; 53% of these showed complete clearance of worm burden by the end of the study. In contrast, another group of male IgG4+ adults showed IgG4 patterns that started to increase between nine months and two years after treatment,

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The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000, and nearly all endemic countries in the Americas, Eastern Mediterranean and Asia-Pacific regions have now initiated the WHO recommended mass drug administration (MDA) campaign to interrupt transmission of the parasite. However, nearly 50% of the LF endemic countries in Africa are yet to implement the GPELF MDA strategy, which does not include vector control. Nevertheless, the recent scale up in insecticide treated /long lasting nets (ITNs/LLINs) and indoor residual spraying (IRS) for malaria control in Africa may significantly impact LF transmission because the parasite is transmitted mainly by Anopheles mosquitoes. This study examined the magnitude, geographical extent and potential impact of vector control in the 17 African countries that are yet to or have only recently started MDA. National data on mosquito bed nets, ITNs/LLINs and IRS were obtained from published literature, national reports, surveys and datasets

Dr. Frank Richards is an expert in parasitic and tropical diseases who has worked extensively in Latin America and Africa. His professional interest is in the safe and effective delivery of available tools to eliminate the transmission of tropical parasitic diseases. The health programs he directs at The Carter Center have helped ministries of health and local communities provide more than half a billion preventive treatments through mass drug administration (MDA) programs in 11 countries.. Richards came to The Carter Center from the U.S. Centers for Disease Control and Prevention (CDC), where he spent 23 years in the Division of Parasitic Diseases and Malaria. Over the course of his career he has worked and published on lymphatic filariasis, schistosomiasis, Guinea worm, neurocysticercosis, and malaria. Richards particular expertise, however, is ivermectin (Mectizan®) MDA programs for river blindness (onchocerciasis). He has been involved in onchocerciasis elimination programs in Latin ...

Recently, AMFI revised these guidelines to simplify the process of change of distributor to make life easy for both-investors and distributors. Previously, the process was cumbersome. In the case of change of distributor on account of the death of a distributor, the old guidelines required the nominee/legal heir of the deceased distributor to get written consent from all the existing clients (irrespective of their city, state, and country). Only upon receiving such consent in writing, the transfer of Assets Under Management (AUM) in the name of the nominee/legal heir of the deceased distributor was possible, which was a challenge for mutual fund distributors. Time and again, AMFI received representations highlighting the practical difficulties in securing the consent from all the clients in writing, and ultimately the modified guidelines are released by AMFI wherein no objection is considered as the consent to the change in ARN request by the nominee distributor. Why should investors go through ...

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Preventive chemotherapy and transmission control (PCT) is the main strategy for control of onchocerciasis, lymphatic filariasis, schistosomiasis, soil-transmitted helminthiasis and trachoma. The strategy involves regular provision of preventive treatment (in the form of mass drug administration (MDA) campaigns) to entire populations or targeted risk groups (e.g. schoolchildren). This strategy reduces disease progression in treated individuals and prevents transmission of infection to others. Mass drug administration (MDA) programmes are rapidly expanding, although important questions remain. For example, will the planned MDA programmes be sufficient to achieve elimination in all epidemiological settings? To what extent is successful elimination jeopardized by low coverage and systematic non-adherence? When, and on the basis of what criteria can MDA be safely interrupted? Each of the modelling analyses highlight the importance of groups who systematically, or semi-systematically do not access MDA ...

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Project Leader: Dr Tim Holt, NIHR Clinical Lecturer Lack of uptake of oral anticoagulants (OAC) in people with atrial fibrillation (AF) is an important public health problem as most are at high risk of stroke, a risk substantially reduced by OAC therapy. Tim is Chief Investigator on this cluster randomised trial supported by NIHR (£610,000). He is collaborating with EMIS, the leading provider of clinical software to UK general practice. Jointly they have developed a tool that interrogates electronic records and flags up people with AF that are eligible for OAC but not taking this treatment. Forty-six practices across England will be randomised to receive or not to receive the installation of this tool. The primary outcome is the proportion of the eligible population that is receiving OAC treatment after six months. If the tool is found to be beneficial and safe it will be possible to disseminate it rapidly throughout the NHS. The project is supported by a qualitative process evaluation. The ...

Nebraska Department of Health and Human Services (DHHS), Division of Public Health, Immunization Program, is issuing this Request for Applications (RFA) for the purpose of selecting qualified recipients of funding This RFA is intended to support activities related to immunizations with the goal of increasing coverage rates among eligible populations. View the documentation under the RFA Immunization Program Sub-awards Category at: http://dhhs.ne.gov/publichealth/Immunization/Pages/forms.aspx - ...

The researchers summed up: Sufficiently weak control measures can lead to a second wave of infections with immune escape variants. That is, when vaccination coverage is only half of the eligible population and NPIs are lifted at this point, with vaccine efficacy at 70%, many more infections were observed to result, especially with variant 2, despite its lower transmissibility, driving a second wave.. Most were probably milder because they were breakthroughs or reinfections. High immune escape promoted the spread of variants 2 and 3, with vaccination being largely ineffective at controlling their spread. However, it should be continued, along with NPIs, to limit the final size of the epidemic with variant 2, though this is of negligible effect with variant 3.. Overall, moderate-level immune escape is likely only to cause a surge of cases if coupled with higher transmissibility. Vaccination helps reduce the final epidemic size even with high levels of immune escape. High vaccine coverage and VE ...

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The overall decrease in outpatient attendance for reported communicable diseases from the 3 months before to the 3 months after mass drug administration was 40·7% (95% CI 39·6-41·8, table 5). A larger decrease was observed for presentations categorised as skin sores, boils, and abscesses (50·9%, 95% CI 48·6-53·1) than for any other presentation of disease. When comparing the 3-month period 12 months before mass drug administration (October to December, 2014) with the 3-month period after (October to December, 2015), we observed a large decrease in attendance for communicable diseases (55·8%, 95% CI 54·8-56·7; appendix ...

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