How is human acidic fibroblast growth factor abbreviated? haFGF stands for human acidic fibroblast growth factor. haFGF is defined as human acidic fibroblast growth factor rarely.
cansSAR 3D Structure of 1RG8_A | HUMAN ACIDIC FIBROBLAST GROWTH FACTOR (HAFGF-1) AT 1.10 ANGSTROM RESOLUTION (140 AMINO ACID FORM) | 1RG8
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TY - JOUR. T1 - Acidic fibroblast growth factor gene 5′ non‐coding exon and flanking region from hamster DDT1 cells. T2 - Identification of the promoter region and transcriptional regulation by testosterone and aFGF protein. AU - Hall, Jeffrey A.. AU - Harris, Marie A.. AU - Intres, Richard. AU - Harris, Stephen E.. PY - 1993/1. Y1 - 1993/1. N2 - Selected clones of Syrian hamster DDT1‐MF2 cells are responsive to testosterone for growth. Heparin binding growth factor 1 (HBGF‐1) or acidic fibroblast growth factor (aFGF) can replace testosterone (T) in the stimulation of growth in these cells. This phenomena is correlated with testosterones ability to elevate aFGF mRNA two‐ to threefold in DDT1 cells. To better understand the possible mechanisms of regulation of aFGF mRNA by steroids and other growth factors, we isolated the aFGF 5′ non‐coding exon and its flanking region from a EMBL3 DDT1 genomic library, using a 5′ non‐coding exon 69 bp DDT1 aFGF cDNA probe. Clones spanning 30 ...
1JQZ: Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil.
1JT4: Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil.
To the best of my knowledge Eusol and Kriingle Pharma have not received much attention here -- would like to get your perspective on the advancements of these two companies; have you heard of them? Do you think it is promising? Any additional information available? Eusol -- they are already in phase III https://en.eusol-biotech.com.tw/service.php ES135 is a recombinant human acidic fibroblast growth factor (rhFGF1) with 135 amino acids. With its effect to promote neurite outgrowth,
To the best of my knowledge Eusol and Kriingle Pharma have not received much attention here -- would like to get your perspective on the advancements of these two companies; have you heard of them? Do you think it is promising? Any additional information available? Eusol -- they are already in phase III https://en.eusol-biotech.com.tw/service.php ES135 is a recombinant human acidic fibroblast growth factor (rhFGF1) with 135 amino acids. With its effect to promote neurite outgrowth,
SWISS-MODEL Template Library (SMTL) entry for 3fjd. Crystal structure of L44F/F132W mutant of Human acidic fibroblast growth factor
Using molecular sieve and electrophoretic mobility shift assays, we established that FGF-1 forms a tight complex with oxLDL in vitro, whereas its affinity to nonatherogenic, native LDL is low. Because the family of FGFs is defined by their high affinity for heparin, which is crucial for their functioning and conformational stabilization, especially in the case of FGF-1,4,9 ⇓ the interaction of FGF-1 with oxLDL discovered in this study is of particular interest in the context of the complex atherosclerotic milieu, where all 3 components (the growth factor, lipoproteins, and HSPGs) might be present simultaneously. The affinities of FGF-1 for oxLDL (Kd=206±9.7 nmol/L) and heparin (Ki=41±3.5 nmol/L) that we determined suggest that the form in which FGF-1 is present in the extracellular environment will depend on local relative concentrations of HSPGs and oxLDL. An HSPG-rich environment favors formation of the high-affinity FGF-1/HSPG/FGFR complex, whereas foci of high oxLDL accumulation might ...
Wu et al reported: "The current study provides important information on the safety, feasibility, and potential effectiveness of this regimen…As little as one motor level or couple of sensory level improvements may increase the quality of life for these patients." They add that their study has "elicited more questions than answers", as information is now needed on the best timing of intervention after injury, the optimum dose, the effective route of administration, and long-term side effects of the treatment. "Prospective, randomised, controlled trials are warranted to corroborate this relatively safe repair strategy.". Writing in an editorial in the Journal of Neurosurgery Spine, Michael Fehlings (Krembil Neuroscience Centre Spinal Program, Toronto Western Hospital, Canada) and Jefferson Wilson (Department of Surgery, Division of Neurosurgery, University of Canada, Canada) say that it is "entirely" possible that the neurological recovery observed was due to the patients natural recovery that ...
SWISS-MODEL Template Library (SMTL) entry for 1dzc.1. High resolution structure of acidic fibroblast growth factor. Mutant FGF-4-ALA-(24-154), 24 NMR structures
FGF acidic/FGF1 products available through Novus Biologicals. Browse our FGF acidic/FGF1 product catalog backed by our Guarantee+.
Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions. ...
Basic fibroblast growth factor (bFGF) and acidic fibroblast growth factor (aFGF) are involved in the induction of embryonic mesoderm, angiogenesis, neuronal differentiation, and proliferation and survival of many cell types. In cardiac myocytes their roles are not well understood. Effects of fibroblast growth factors on reexpression of fetal actin genes have been reported. In freshly isolated adult rat cardiac myocytes, bFGF mRNA was not detectable by in situ hybridization, although the cells contained significant amounts of bFGF and aFGF as quantified by radioimmunoassays, mitogen assays with immunoneutralization, and Western blotting. After culturing, bFGF mRNA was detected (aFGF mRNA was not studied), and the cells contained 2.5-fold more bFGF and 60% more aFGF than freshly isolated cells. The FGFs were not found in conditioned medium. They were localized, especially in cultured cells, to the nucleus. Cultured myocytes bound fourfold more 125I-FGF than freshly isolated cells and expressed the ...
TY - JOUR. T1 - Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. AU - Yoshida, Kazunari. AU - Gage, Fred H.. PY - 1992/1/8. Y1 - 1992/1/8. N2 - Acidic fibroblast growth factor (aFGF) enhances nerve growth factor (NGF) synthesis by astrocytes obtained from various brain regions. NGF secretion by fibrous-shaped astrocytes transformed by dibutyryl-cAMP (db-cAMP) pretreatment was less than that by untreated astrocytes. However, aFGF also enhanced NGF secretion by fibrous-shaped astrocytes. The effects of various kinds of intracellular signaling modulators on NGF synthesis were examined. None of the following second messenger effectors had an effect on NGF synthesis: protein kinase C (PKC) agonist (phorbol myristate acetate (PMA)) or antagonist (sphingosine (SP)). LiCl, and ionomycin (Iono). Further, increases of intracellular cAMP by forskolin (FK) or db-cAMP have no significant effect on NGF ...
TABLE-US-00001 TABLE 1 Examples of Biologically Active Agents Adenovirus with or without genetic material Angiogenic agents Angiotensin Converting Enzyme Inhibitors (ACE inhibitors) Angiotensin II antagonists Anti-angiogenic agents Antiarrhythmics Anti-bacterial agents Antibiotics Erythromycin Penicillin Anti-coagulants Heparin Anti-growth factors Anti-inflammatory agents Dexamethasone Aspirin Hydrocortisone Antimicrobial Antioxidants Anti-platelet agents Forskolin Anti-proliferation agents Anti-rejection agents Rapamycin Anti-restenosis agents Antisense Anti-thrombogenic agents Argatroban Hirudin GP IIb/IIIa inhibitors Anti-virus drugs Arteriogenesis agents acidic fibroblast growth factor (aFGF) angiogenin angiotropin basic fibroblast growth factor (bFGF) Bone morphogenic proteins (BMP) epidermal growth factor (EGF) fibrin granulocyte-macrophage colony stimulating factor (GM-CSF) hepatocyte growth factor (HGF) HIF-1 insulin growth factor-1 (IGF-1) interleukin-8 (IL-8) MAC-1 nicotinamide ...
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008 ...
Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. We have demonstrated previously a pronounced increase in the expression of hepatocyte growth factor (HGF) (Z. Hu, R. P. Evarts, K. Fujio, E. R. Marsden, and S. S. Thorgeirsson, Am. J. Pathol., 142: 1823-1830, 1993), transforming growth factor alpha (TGF-alpha) (R. P. Evarts, H. Nakatsukasa, E. R. Marsden, Z. Hu, and S. S. Thorgeirsson, Mol. Carcinog., 5: 25-31, 1992), and acidic fibroblast growth factor (aFGF) (E. R. Marsden, Z. Hu, K. Fujio, H. Nakatsukasa, S. S. Thorgeirsson, and R. P. Evarts, Lab. Invest., 67: 427-433, 1992) that coincided with the proliferation and differentiation of putative hepatic stem cells and perisinusoidal stellate (Ito) cells. Here, we examine the earliest stages of stem cell activation in rat liver using an experimental model involving treatment with acetylaminofluorene and partial hepatectomy (R. P. Evarts, P. Nagy, E. Marsden, and S. S. ...
TY - JOUR. T1 - Identification of a binding site on human FGF-2 for fibrinogen. AU - Peng, Hu. AU - Sahni, Abha. AU - Fay, Philip. AU - Bellum, Stephen. AU - Prudovsky, Igor. AU - Maciag, Thomas. AU - Francis, Charles W.. PY - 2004/3/15. Y1 - 2004/3/15. N2 - Endothelial cell adhesive interactions are mediated by both fibrinogen and fibrin, and growth is stimulated by fibroblast growth factor 2 (FGF-2). We have shown previously that FGF-2 binds specifically and with high affinity to fibrinogen and fibrin and that fibrinogen potentiates the proliferative capacity of FGF-2 and also protects it from proteolytic degradation. To further characterize this interaction we have performed FGF-2 mutagenesis to identify the interactive site. Because FGF-1 has a similar structure to FGF-2 but does not bind to fibrinogen, we used a strategy of cassette and site-directed mutagenesis, exchanging residues from FGF-1 and FGF-2 and correlating structural changes with fibrinogen binding. Two cassette interchange ...
FGF-8b stands for fibroblast growth factor 8b. Human FGF-8b is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. - Belgique
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RASGRP1 to translocate to the Golgi apparatus, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. The receptor protein tyrosine phosphatase PTPmu (PTPRM) is capable of dephosphorylating PLCG1.[7] Two transcript variants encoding different isoforms have been found for this gene.[8] Common to all PLC isozymes, PLCG1 consists of an N-terminal PH domain, which translocates PLC to the plasma membrane and binds PIP3;[9] four EF hands; an X and Y catalytic region comprising ...
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
MAA551Hu22, Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2), 碱性成纤维细胞生长因子(FGF2)单克隆抗体, B-FGF; BFGF; FGFB; HBGH-2; Basic Fibroblast Growth Factor; Heparin-binding growth factor 2 | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Fibroblast growth factor-2 labeling intensity in GFAP-positive ad GFAP-negative cells compared to sham-operated cases in the four examined regions of the CNS. T
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development,
K04357 EGF; epidermal growth factor K08774 TGFA; transforming growth factor, alpha K18496 FGF1; fibroblast growth factor 1 K18497 FGF2; fibroblast growth factor 2 K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K04358 FGF; fibroblast growth factor K02582 NGFB; nerve growth factor, beta K04355 BDNF; brain-derived neurotrophic factor K04356 NTF3; neurotrophin 3 K12457 NTF4; neurotrophin 4 ...
Alternative initiations of translation of the human fibroblast growth factor 2 (FGF-2) mRNA, at three CUG start codons and one AUG start codon, result in the synthesis of four isoforms of FGF-2. This process has important consequences on the fate of FGF-2: the CUG-initiated products are nuclear and their constitutive expression is able to induce cell immortalization, whereas the AUG-initiated product, mostly cytoplasmic, can generate cell transformation. Thus, the different isoforms probably have distinct targets in the cell. We show here that translation initiation of the FGF-2 mRNA breaks the rule of the cap-dependent ribosome scanning mechanism. First, translation of the FGF-2 mRNA was shown to be cap independent in vitro. This cap-independent translation required a sequence located between nucleotides (nt) 192 and 256 from the 5 end of the 318-nt-long 5 untranslated region. Second, expression of bicistronic vectors in COS-7 cells indicated that the FGF-2 mRNA is translated through a ...
Migration of endothelial cells is involved in normal and pathological angiogenesis and in re-endothelialization after vascular injury or rupture of atherosclerotic plaques. Several types of endothelial cells are known to synthesize basic fibroblast growth factor (bFGF); in some of these, migration is increased by exogenous bFGF and inhibited by anti-bFGF antibodies. Using immunocytochemical techniques and RNase protection analysis, we studied endothelial cells from bovine coronary arteries and veins as well as from adrenal microvessels. We found that bFGF mRNA and peptide were present in confluent endothelial cells and were upregulated during migration stimulated by removal of some cells from the monolayer. During migration, extracellular matrix stores of bFGF were depleted, and bFGF immunoreactivity began to accumulate in the cytoplasm of endothelial cells between 2 and 6 hours. After migration had begun, but before the initiation of DNA synthesis, bFGF immunoreactivity increased in the nuclei ...
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Shop Fibroblast growth factor ELISA Kit, Recombinant Protein and Fibroblast growth factor Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Fibroblast growth factors (FGFs) play a critical role in diverse physiological processes and the pathogenesis of diseases. Integrins are involved in FGF signaling, since integrin antagonists suppress FGF signaling. This is called integrin-FGF crosstalk, while the specifics of the crosstalk are unclear. This review highlights recent findings that FGF1 directly interacts with integrin αvβ3, and the resulting integrin-FGF-fibroblast growth factor receptor (FGFR) ternary complex formation is essential for FGF1-induced cell proliferation, migration and angiogenesis. An integrin-binding defective FGF1 mutant (Arg-50 to Glu, R50E) is defective in ternary complex formation and in inducing cell proliferation, migration and angiogenesis, while R50E still binds to the FGF receptor and heparin. In addition, R50E suppressed tumorigenesis in vivo, while wild-type (WT) FGF1 enhanced it. Thus, the direct interaction between FGF1 and integrin αvβ3 is a potential therapeutic target, and R50E is a potential
PD166866 (N-[2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N-(1,1-dimethylethyl)-urea) -Inhibitor of basic Fibroblast Growth Factor (bFGF)
The cardiovascular effects of proteolysis of high molecular weight basic fibroblast growth factor by inflammatory serine proteases
TY - THES. T1 - Melanoma, the role of basic Fibroblast Growth Factor in the aggressive behaviour and chemotherapy response. AU - Fontijn, D.. N1 - Naam instelling promotie: S.l.. PY - 2009. Y1 - 2009. M3 - Research VU University Amsterdam, graduation VU University Amsterdam. SN - 9789086593200. PB - s.n.. CY - S.l.. ER - ...
TY - JOUR. T1 - Gene targeted ablation of high molecular weight fibroblast growth factor-2. AU - Azhar, Mohamad. AU - Yin, Moying. AU - Zhou, Ming. AU - Li, Hongqi. AU - Mustafa, Marwan. AU - Nusayr, Eyad. AU - Keenan, Jack B.. AU - Chen, Hwudaurw. AU - Pawlosky, Sharon. AU - Gard, Connie. AU - Grisham, Christina. AU - Sanford, L. Philip. AU - Doetschman, Tom. PY - 2009/2/1. Y1 - 2009/2/1. N2 - Fibroblast growth factor-2 (FGF2) is produced as high molecular weight isoforms (HMW) and a low molecular weight isoform (LMW) by means of alternative usage of translation start sites in a single Fgf2 mRNA. Although the physiological function of FGF2 and FGF2 LMW has been investigated in myocardial capillarogenesis during normal cardiac growth, the role of FGF2 HMW has not been determined. Here, we report the generation of FGF2 HMW-deficient mice in which FGF2 HMW isoforms are ablated by the Tag-and-Exchange gene targeting technique. These mice are normal and fertile with normal fecundity, and have a ...
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
Fibroblast growth factors (FGFs) and their receptors (FGF receptors) constitute a signalling system conserved throughout animal evolution
Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver. (HEPATOLOGY 2012;56:2404-2411) ...
A fibroblast growth factor that may play a role in regulation of HAIR FOLLICLE phenotype. Spontaneous mutation of the gene for this protein results in a strain of MICE with abnormally long hair, referred to as angora mice ...
House, Stacey; Belanger, Thomas; Weinheimer, Carla; Ornitz, David, "Fibroblast growth factor 2 affects vascular remodeling after acute myocardial infarction" (2012). Conference Abstracts and Posters. Paper 8. http://digitalcommons.wustl.edu/em_conf/8. ...
FGF8 - FGF8 (untagged)-Human fibroblast growth factor 8 (androgen-induced) (FGF8), transcript variant B available for purchase from OriGene - Your Gene Company.
Bagai S, Rubio E, Cheng JF, Sweet R, Thomas R, Fuchs E, Grady R, Mitchell M, Bassuk JA. Fibroblast growth factor-10 is a mitogen for urothelial cells. J Biol Chem. 2002 Jun 28; 277(26):23828-37 ...
An isolated DNA sequence encoding an angiogenic factor protein consisting of a single-polypeptide-chain protein having at least one active site possessing mitotic and chemotactic activity and the abil
KOYAMA Tadaaki , HASEBE Takahiro , TSUDA Hitoshi , HIROHASHI Setsuo , SASAKI Satoshi , FUKUTOMI Takashi , IMOTO Shigeru , UMEDA Toru , MUKAI Kiyoshi Japanese journal of cancer research : gann 90(3), 294-300, 1999-03-31 医中誌Web 参考文献16件 被引用文献1件 ...
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
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Fibroblast growth factor-21 (FGF21) belongs to the large FGF family which has at least 23 members. Along with FGF-19/15 and FGF-23, FGF-21 is categorized as a member of the atypical FGF subfamily, as it must be complexed to the Klotho co-receptor in order to bind to the FGF receptors and activate...
Fgf3 - Fgf3 (untagged ORF) - Rat fibroblast growth factor 3 (Fgf3), (10 ug) available for purchase from OriGene - Your Gene Company.