TY - JOUR. T1 - ACR appropriateness criteria® growth disturbances-risk of intrauterine growth restriction. AU - Zelop, Carolyn M.. AU - Javitt, Marcia C.. AU - Glanc, Phyllis. AU - Dubinsky, Theodore. AU - Harisinghani, Mukesh G.. AU - Harris, Robert D.. AU - Khati, Nadia J.. AU - Mitchell, Donald G.. AU - Pandharipande, Pari V.. AU - Pannu, Harpreet K.. AU - Podrasky, Ann E.. AU - Shipp, Thomas D.. AU - Siegel, Cary Lynn. AU - Simpson, Lynn. AU - Wall, Darci J.. AU - Wong-You-Cheong, Jade J.. PY - 2013/9. Y1 - 2013/9. N2 - Fetal growth disturbances include fetuses at risk for intrauterine growth restriction. These fetuses may have an estimated fetal weight at less than the 10% or demonstrate a plateau of fetal growth with an estimated fetal growth greater than the 10%. Uteroplacental insufficiency may play a major role in the etiology of intrauterine growth restriction. Fetuses at risk for intrauterine fetal growth restriction are susceptible to the potential hostility of the intrauterine ...
Severe intrauterine growth restriction (IUGR) is recognised to be a major cause of perinatal morbidity and mortality. Identifying the fetus that is truly growth restricted and therefore compromised, from the one that is simply genetically small and not at risk is difficult. Recent work using umbilical artery (UA) Doppler waveform studies have shown that a reduction in the diastolic component of the UA Doppler waveform correlates strongly with poor perinatal outcome. Since this technique can be used to reliably distinguish the truly growth restricted fetus at risk, it is imperative, if we are to understand the pathophysiology of severe IUGR, that the mechanisms by which abnormal Doppler waveforms arise is established. The elaboration pattern of blood vessels within stem villi from IUGR and gestationally age- matched control placentas, was first evaluated by measuring the diameter of 600 vessel profiles, identified by the antibody anti-a smooth muscle actin, within stem villi from randomly chosen ...
Manara L. Intrapartum fetal morbidity and mortality in intrauterine growth-retarded infants. J Am Osteopath Assoc 1980;80(2):101. doi: 10.7556/jaoa.1980.80.2.101.. Download citation file:. ...
Fetal growth restriction and preeclampsia are both conditions of placental etiology and associated to increased risk for the long-term development of cardiovascular disease in the mother. At presentation, preeclampsia is associated with maternal global diastolic dysfunction, which is determined, at least in part, by increased afterload and myocardial stiffness. The aim of this study is to test the hypothesis that women with normotensive fetal growth-restricted pregnancies also exhibit global diastolic dysfunction. This was a prospective case-control study conducted over a 3-year period involving 29 preterm fetal growth-restricted pregnancies, 25 preeclamptic with fetal growth restriction pregnancies, and 58 matched control pregnancies. Women were assessed by conventional echocardiography and tissue Doppler imaging at diagnosis of the complication and followed-up at 12 weeks postpartum. Fetal growth-restricted pregnancies are characterized by a lower cardiac index and higher total vascular ...
Intrauterine growth retardation predisposes toward long-term morbidity from type 2 diabetes and cardiovascular disease. To explain this association, the concept of programming was introduced to indicate a process whereby a stimulus or insult at a critical period of development has lasting or lifelong consequences on key endocrine and metabolic pathways. Subtle changes in cell composition of tissues, induced by suboptimal conditions in utero, can influence postnatal physiological functions. There is increasing evidence, suggesting that liver may represent one of the candidate organs targeted by programming, undergoing structural, functional and epigenetic changes following exposure to an unfavorable intrauterine environment. The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine growth restriction.
TY - JOUR. T1 - Maternal amino acid supplementation for intrauterine growth restriction. AU - Brown, Laura D.. AU - Green, Alice S.. AU - Limesand, Sean W. AU - Rozance, Paul J.. PY - 2011/1/1. Y1 - 2011/1/1. N2 - Maternal dietary protein supplementation to improve fetal growth has been considered as an option to prevent or treat intrauterine growth restriction. However, in contrast to balanced dietary supplementation, adverse perinatal outcomes in pregnant women who received high amounts of dietary protein supplementation have been observed. The responsible mechanisms for these adverse outcomes are unknown. This review will discuss relevant human and animal data to provide the background necessary for the development of explanatory hypotheses and ultimately for the development therapeutic interventions during pregnancy to improve fetal growth. Relevant aspects of fetal amino acid metabolism during normal pregnancy and those pregnancies affected by IUGR will be discussed. In addition, data from ...
Intrauterine growth restriction (IUGR) is a term used to describe a condition in which the fetus is smaller than expected for the number of weeks of pregnancy. Another term for IUGR is fetal growth restriction. Newborn babies with IUGR are often described as small for gestational age (SGA).. A fetus with IUGR often has an estimated fetal weight less than the 10th percentile. This means that the fetus weighs less than 90 percent of all other fetuses of the same gestational age. A fetus with IUGR also may be born at term (after 37 weeks of pregnancy) or prematurely (before 37 weeks).. Newborn babies with IUGR often appear thin, pale, and have loose, dry skin. The umbilical cord is often thin and dull-looking rather than shiny and fat. Babies with IUGR sometimes have a wide-eyed look. Some babies do not have this malnourished appearance but are small all-over.. ...
Intrauterine growth restriction (IUGR) is a term used to describe a condition in which the fetus is smaller than expected for the number of weeks of pregnancy. Another term for IUGR is fetal growth restriction. Newborn babies with IUGR are often described as small for gestational age (SGA).. A fetus with IUGR often has an estimated fetal weight less than the 10th percentile. This means that the fetus weighs less than 90 percent of all other fetuses of the same gestational age. A fetus with IUGR also may be born at term (after 37 weeks of pregnancy) or prematurely (before 37 weeks).. Newborn babies with IUGR often appear thin, pale, and have loose, dry skin. The umbilical cord is often thin and dull-looking rather than shiny and fat. Babies with IUGR sometimes have a wide-eyed look. Some babies do not have this malnourished appearance but are small all-over.. ...
Reported are the results of a community-based prospective study in four urban squatter settlements in Karachi that was carried out to assess the incidence of and risk factors for intrauterine growth retardation. The incidence of term intrauterine growth retardation was 24.4% among 738 singleton births. The socioeconomic and biological risk factors that were found to be statistically significant in a bivariate analysis were included in a logistic regression model to assess their independent effects. The major risk factors were low level of maternal education, paternal unemployment, consanguinity, short birth-to-conception intervals, short maternal stature, and low maternal weight. The population risk estimates suggest the desirability of public health interventions to improve maternal weight and birth spacing and of improvements in socioeconomic conditions, especially maternal education. Public education programmes to discourage consanguineous marriages should also be considered.
Doctors give unbiased, helpful information on indications, contra-indications, benefits, and complications: Dr. Handsfield on intrauterine growth restriction vdrl rpr positive: Both tests are 100% conclusive at that time -- in fact, much earlier. That HIV test is conclusive at 4 weeks and RPR at 6 weeks.
TY - JOUR. T1 - The relationship between the placental serotonin pathway and fetal growth restriction. AU - Ranzil, Suveena. AU - Walker, David W.. AU - Borg, Anthony J.. AU - Wallace, Euan M.. AU - Ebeling, Peter R.. AU - Murthi, Padma. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.. AB - Fetal ...
Intrauterine growth restriction (IUGR) programs hypertension and endothelial dysfunction at 4 months of age in male IUGR rat offspring compared to male control. Male IUGR offspring at 4 months of age exhibit a significant decrease in the blood pressure (BP) response to chronic NG-nitro-L-arginine methyl ester (L-NAME, 10mg/kg/day) compared to age-matched male control. Albuminuria is also significantly reduced in L-NAME treated male IUGR relative to L-NAME treated male control suggesting that IUGR programs a reduction in bioavailability of nitric oxide (NO). Decreased NO bioavailability by endothelial dysfunction can contribute to increased BP. Age is a risk factor for hypertension and aging is associated with an increase in arterial stiffening and endothelial dysfunction. BP is similar in male IUGR relative to male control by 18 months of age. Thus, this study tested the hypothesis that age-induced reductions in NO bioavailability in the male control rat would abolish the IUGR-induced ...
Cerebral Doppler measurements seem to be a future method to evaluate the degree of fetal hypoxemia. The aim of this study was (1) to elaborate standard curves for the different cerebral vessels in our own population, and (2) to describe the predictive value of Doppler measurements for intrauterine growth retardation (IUGR) and fetal acidosis. We recorded cerebral flow velocity waveforms from 71 normal pregnancies to establish standard curves for the following vessels: proximal middle cerebral artery, distal middle cerebral artery and posterior cerebral artery. Finally, we calculated the cerebroplacentar index (CPI) for each case. The predictive values from the different vessels were determined in 24 patients with IUGR and 17 cases with fetal acidosis. The poor sensitivity and the low positive predictive value of each cerebral vessel is probably explained by the rather long interval between the last Doppler assessment and delivery (22 +/- 23 days). Reducing the interval to less than 7 days, the distal
IUGR stands for intrauterine growth restriction and simply means that the unborn baby has not grown to a size that is expected for a certain stage of pregnancy. In other words the fetus is smaller than expected. The more correct medical definition is a fetal weight below the 10th percentile for gestational age as measured on ultrasound. It is also known as small for gestational age (SGA).. This can occur for any number of reasons and sometimes the baby may appear smaller in size on ultrasound but is actually a normal size when born. It is also possible that some babies are just naturally smaller in size. The problem is when the babies smaller size is due to some impairment while it is growing in the uterus thereby preventing the fetus from growing to its natural size.. ...
Objective To examine the association between intrauterine growth restriction (IUGR) status at birth among full-term infants, exposure to substance use during pregnancy, and risk of hypertension at 6 years of age. Design Prospective evaluation of high-risk children. Setting Four centers of the National Institute of Child Health and Human Development Neonatal Research Network.
OBJECTIVE: The purpose of this prospective study was to record endothelin-1 (ET-1) concentrations in the second trimester amniotic fluid and compare these values in women who developed intrauterine growth restriction (IUGR) later in pregnancy with th
Karen Simmer, R P H Thompson; Leucocyte Zinc and Intrauterine Growth Retardation. Clin Sci (Lond) 1 January 1984; 67 (s9): 46P-47P. doi: https://doi.org/10.1042/cs067046Pb. Download citation file:. ...
O36.5924 is a billable code used to specify a medical diagnosis of maternal care for other known or suspected poor fetal growth, second trimester, fetus 4. Code valid for the year 2020
Early dating of pregnancy by ultrasound is necessary to establish the adequate fetal growth. Customized or individualized estimation of fetal growth is probably a better option than population based curves to identify fetuses at a higher risk of perinatal complications. Biological maternal markers and placental evaluation might contribute in the identification of fetuses at risk of abnormal growth. There is no specific Doppler pattern of fetal deterioration; however, in early growth restriction it is mainly expressed in the umbilical artery, and in late growth restriction (>34 weeks) in the middle cerebral artery. Abnormal biophysical profile and/or non-stress test can be considered as acute signs of fetal decompensation. Magnetic resonance imaging can provide information of fetuses at risk of abnormal neurodevelopment. Neonatal body composition in low birthweight newborns can be used to identify children at risk of metabolic complications. Gestational age at delivery is the most important ...
Glucose is the most important fetal nutrient and the production of this substrate increases in the pregnant woman. In the last trimester the increased insulin resistance directs energy substrates to the fetus. Fetal growth is sometimes disturbed, often without an obvious explanation.. After birth the newborn infant must produce its own glucose, primarily for the brain. Fatty acids from lipolysis are also important energy substrates. Hypoglycaemia can be a problem, occurring frequently in preterm infants and infants born small for gestational age (SGA). In addition, SGA infants are at risk of developing the metabolic syndrome in adulthood. Neonatal medication can influence energy metabolism. One such medication is theophylline, administered in preterm infants to prevent apnoea. We investigated energy substrate production in women with normal and IUGR pregnancies, in preterm neonates, before and after theophylline treatment and in newborn SGA infants, using stable isotope-labelled compounds and ...
The principal goal of our research program is to elucidate the underlying molecular mechanisms that link fetal growth retardation to the later development of obesity and type 2 diabetes in adulthood. We currently have 3 major projects and several smaller projects. The first project focuses on the relationship between oxidative stress and ß-cell dysfunction and insulin resistance. We have developed a model of fetal growth retardation in the rodent (mice and rats) which leads to the later development of diabetes and obesity in adult animals. We have established that fetal growth retardation induces progressive mitochondrial dysfunction, oxidative stress, mtDNA mutations, and electron transport defects. These defects cause abnormal ß-cell function and development, and hepatic and muscle insulin resistance. Oxidative stress decreases transcription of key genes related to ß-cell development, induces modifications of proteins of the Krebs cycle in the liver, and muscle. Pdx-1 is a critical ...
Most of the babies were born at full term, with an average birth weight of 3450g (which is around the UK average), while 4% were born prematurely, 0.3% were stillborn, and 0.7% were miscarried late. Overall, the results confirmed that these were low risk pregnancies. However, the authors found a dose-response relationship, showing that increasing caffeine intake was associated with increasing risk of fetal growth restriction (FGR).. Compared to pregnant women consuming less than 100mg/day (the equivalent of less than one cup of coffee), the risk estimates of having a lower birth weight baby increased by 20% for intakes of 100-199mg/day, by 50% for those taking between 200-299mg/day, and by 40% for over 300mg/day.. There was no level of caffeine intake at which the increased risk of FGR stopped increasing during pregnancy. Caffeine consumption of more than 100mg/day, the equivalent of one cup of coffee, was associated with a reduction in birth weight of 34-59g in the first, 24-74g in the ...
Approximately one-tenth of all pregnancies are complicated by fetal growth retardation, a condition which significantly increases the risk of fetal morbidity and mortality. Antepartum diagnosis with ultrasound, including qualitative amniotic fluid vo
Reproduced from: Malacova E, Regan A, Nassar N, Raynes-Greenow C, Leonard H, Srinivasjois R, Shand A, Lavin T, Pereira G. Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: systematic review and meta-analysis. BJOG 2018;125:183-192 https://doi.org/10.1111/1471-0528.14906. ...
TY - JOUR. T1 - Multidisciplinary consensus on screening for, diagnosis and management of fetal growth restriction in the Netherlands. AU - IRIS study group. AU - Verfaille, Viki. AU - de Jonge, Ank. AU - Mokkink, Lidwine. AU - Westerneng, Myrte. AU - van der Horst, Henriëtte. AU - Jellema, Petra. AU - Franx, Arie. AU - Bais, Joke. AU - Bonsel, Gouke J.. AU - Bosmans, Judith E.. AU - van Dillen, Jeroen. AU - van Duijnhoven, Noortje T.L.. AU - Grobman, William A.. AU - Groen, Henk. AU - Hukkelhoven, Chantal W.P.M.. AU - Klomp, Trudy. AU - Kok, Marjolein. AU - de Kroon, Marlou L.. AU - Kruijt, Maya. AU - Kwee, Anneke. AU - Ledda, Sabina. AU - Lafeber, Harry N.. AU - van Lith, Jan M.. AU - Mol, Ben Willem. AU - Molewijk, Bert. AU - Nieuwenhuijze, Marianne. AU - Oei, Guid. AU - Oudejans, Cees. AU - Paarlberg, K. Marieke. AU - Pajkrt, Eva. AU - Papageorghiou, Aris T.. AU - Reddy, Uma M.. AU - De Reu, Paul A.O.M.. AU - Rijnders, Marlies. AU - de Roon-Immerzeel, Alieke. AU - Scheele, Connie. AU - ...
Late intrauterine growth restriction is infrequently diagnosed with an overall sensitivity of 40 % in low-risk pregnancies. In addition, late intrauterine growth restriction may be associated with intrauterine death and poor neonatal outcomes i.e. birth asphyxia and hospitalization in intensive care unit. The investigators hypothesis that a later third trimester routine ultrasound may be more accurate to diagnose late intrauterine growth restriction ...
Poor fetal growth, also known as intrauterine growth restriction (IUGR), is a worldwide health concern. IUGR is commonly associated with both an increased risk in perinatal mortality and a higher prevalence of developing chronic metabolic diseases later in life. Obesity, type 2 diabetes or metabolic syndrome could result from noxious
Objective: (1) To describe the sex-specific, birth weight distribution by gestational age of babies born in a malaria endemic, rural area with high maternal HIV prevalence; (2) to assess the contribution of maternal health, nutritional status and obstetric history on intra-uterine growth retardation (IUGR) and prematurity. Methods: Information was collected on all women attending antenatal services in two hospitals in Chikwawa District, Malawi, and at delivery if at the hospital facilities. New-borns were weighed and gestational age was assessed through post-natal examination (modified Ballard). Sex-specific growth curves were calculated using the LMS method and compared with international reference curves. Results: A total of 1423 live-born singleton babies were enrolled; 14.9% had a birth weight , 2500 g, 17.3% were premature (, 37 weeks) and 20.3% had IUGR. A fall-off in Malawian growth percentile values occurred between 34 and 37 weeks gestation. Significantly associated with increased IUGR ...
IUGR is when a baby in the womb doesnt grow at the expected rate during the pregnancy. Women with IUGR should eat a healthy diet; get enough sleep; and avoid alcohol, drugs, and tobacco.
IUGR is when a baby in the womb doesnt grow at the expected rate during the pregnancy. Women with IUGR should eat a healthy diet; get enough sleep; and avoid alcohol, drugs, and tobacco.
WHAT DOES THE TERM "SGA" (SMALL FOR GESTATIONAL AGE) MEAN?. SGA (small for gestational age) generally describes any infant whose birth weight and/or birth length was less than the 3rd percentile, adjusted for prematurity (gestational age). Between 3% and 10% of live births each year are diagnosed as SGA. In addition, when ultrasound evidence demonstrated poor fetal growth while in-utero, an infant may also be described as "IUGR", which means the fetus experienced intrauterine growth restriction.. The factors behind why an infant is born SGA can be quite complex. The factors include fetal (such as genetic syndrome), maternal (such as substance use or infection), placental, and/or demographic (mothers age, income level - these are both rare).. But setting aside these possible causes, 9 out of 10 infants born SGA do experience catch-up growth by the age of 2 years, and usually by 6 months of age. Catch-up growth typically means that the childs length curve moves upward, crossing the 3rd ...
Women with IBD overall did well during pregnancy; but rates of Caesarean section and intrauterine growth retardation (low birth weight babies) were higher than in women without IBD. Of the patients with Crohns disease (CD), those with quiescent-to-mild CD had similar outcomes to women without IBD; however, women with moderate to severe CD had a higher rate of miscarriage and almost a 3-fold higher rate of intrauterine growth retardation than women without IBD.. "Previous studies could be easily biased since considerable numbers of pregnant women with IBD with quiescent or mild activity were likely to be excluded. We overcame this limitation by using a nationwide database covering 98% of the 52 million citizens of an entire nation" said corresponding author Bo-In Lee, MD, PhD, of The Catholic University of Korea.. ...
Allergic susceptibility is associated with early life exposures, including intrauterine growth restriction and maternal allergy. Epidemiological and animal model studies suggest that restricted growth before birth is protective against later allergy development, whilst maternal allergy is generally associated with increased allergy risk in progeny. Causality and mechanisms mediating these associations are poorly understood, and I therefore investigated immune and allergic responses in ovine models following these prenatal exposures. The first aim of study one (chapter 2) was to determine the effects of intrauterine growth restriction, due to placental restriction (PR), on allergic susceptibility. The second aim (chapter 3) was to determine the effects of maternal dietary methyl donor and cofactor supplementation during late pregnancy on allergic susceptibility of PR progeny, since methyl donors can regulate gene methylation via the one-carbon pathway. Placental restriction was induced by ...
This trial is conducted in Europe. The aim of this trial is to assess and compare the efficacy and safety of two dose levels of somatropin over a long period (till final height is reached). This trial is an extension to trials GHRETARD/BDP/14/NL (a 2-year initial trial) and GHRETARD/BPD/20/NL (a 2-year extension trial ...
Household air pollution (HAP) is the eighth leading risk factor for global disease burden, contributing to 2.9 million yearly premature deaths. Nearly 80% of the sub-Saharan population and about 90 million households in Nigeria use biomass as their primary fuel for cooking and energy needs, which can adversely impact their health. Exposure to air pollution has been linked to adverse pregnancy outcomes like stillbirth, preeclampsia, preterm birth, low birth weight, reduced fetal head circumference, miscarriage, and intra-uterine fetal growth retardation (IUGR). ...
DLK1 (PREF1 and FA1) is a paternally expressed gene located in the human chromosome 14q32 imprinting cluster, approximately 90 kb away from the maternally expressed non-coding RNA gene MEG3 (also called GTL2). DLK1 encodes a transmembrane glycoprotein with six epidermal growth factor-like repeat motifs [64], known to be involved in adipogenesis [65]. Dlk1-null mice show high perinatal lethality, pre- and postnatal growth restriction followed by an obese phenotype [37], suggesting that it acts as a growth promoter.. In this study, the expression levels of DLK1 (all isoforms) in CVS (n = 99) and term placenta (n = 272) were correlated to fetal growth parameters. For the CVS analysis, only the tissues from extreme birthweight babies (less than 10th centile and more than 90th centile) were used. Using the regression model as described for H19, we did not observe any association between DLK1 expression and birthweight (p = 0.23) or with CRL (p = 0.16). However, term placental DLK1 expression did show ...
Research question: The symptoms of preterm labour and preterm delivery stand at the end of a pathophysiological process which is understood up to now insufficiently. So it does not amaze if previous preventive and therapeutic strategies have brought inadequate successes in the prevention of preterm delivery. Similar one is to be arrested for the intrauterine fetal growth retardation which represents presumably the result of a process beginning very early in the pregnancy. Some studies give evidence for psychosocial conditions for the process of pregnancy and birth. On the one hand fundamental deficits of previous investigations are in the disregard of important psychosocial performance-influencing factors (in particular fears, biographic factors, social network and partnership), on the other hand the retrospective design limits the informative value. Material and means: In the present prospective study 589 women between 16th and 22nd week of pregnancy were examined using a questionnaire that was ...
Research question: The symptoms of preterm labour and preterm delivery stand at the end of a pathophysiological process which is understood up to now insufficiently. So it does not amaze if previous preventive and therapeutic strategies have brought inadequate successes in the prevention of preterm delivery. Similar one is to be arrested for the intrauterine fetal growth retardation which represents presumably the result of a process beginning very early in the pregnancy. Some studies give evidence for psychosocial conditions for the process of pregnancy and birth. On the one hand fundamental deficits of previous investigations are in the disregard of important psychosocial performance-influencing factors (in particular fears, biographic factors, social network and partnership), on the other hand the retrospective design limits the informative value. Material and means: In the present prospective study 589 women between 16th and 22nd week of pregnancy were examined using a questionnaire that was ...
Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease ...
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OBJECTIVE:Although fetal growth restriction (FGR) is well known to be associated with adverse outcomes for the mother and offspring, effective interventions for the management of FGR are yet to be established. Trials reporting interventions for the prevention and treatment of FGR may be limited by heterogeneity in the underlying pathophysiology. The aim of this study was to conduct a systematic review of outcomes reported in randomized controlled trials (RCTs) assessing interventions for the prevention or treatment of FGR, in order to identify and categorize the variation in outcome reporting. METHODS:MEDLINE, EMBASE and The Cochrane Library were searched from inception until August 2018 for RCTs investigating therapies for the prevention and treatment of FGR. Studies were assessed systematically and data on outcomes that were reported in the included studies were extracted and categorized. The methodological quality of the included studies was assessed using the Jadad score. RESULTS:The search ...
May cause prolonged constriction of the uterine vessels and/or increased myometrial tone leading to reduced placental blood flow. This has contributed to fetal growth retardation in ...
(2000) Kwong et al. Development. Epidemiological studies have indicated that susceptibility of human adults to hypertension and cardiovascular disease may result from intrauterine growth restriction and low birth weight induced by...
Im a 2nd time mommy and I am praying daily for a successful vbac! My first had IUGR (intra-uterine growth restriction) and handled labor with a lot...
Definition: Intrauterine growth restriction describes poor growth of a fetus. Specifically, it refers to a fetus whose weight is below the 10th percentile for gestational age.. ...
Question - How much weight should be gained during pregnancy?. Ask a Doctor about diagnosis, treatment and medication for Intrauterine growth retardation, Ask an OBGYN, Maternal and Fetal Medicine
... , Rong Wu, Li-hua Li, Li-jun Xue, Wen-ying Xu, Zhao-fang Tian
Epidemiological studies have shown that markers of poor fetal growth, including low early weight, thinness, and shortness at birth, are associated with increased mortality and morbidity from cardiovascular disease in later life.1 3 Correlations have also been shown between poor early growth and the major cardiovascular risk factors-raised blood pressure,4raised plasma fibrinogen5 and serum cholesterol concentrations,6 impaired glucose tolerance7and reduced arterial compliance.8 These associations were first established by studies in Hertfordshire, where from 1911 to 1948, every newborn baby was weighed and followed up to the age of 1 year. The prevalence of non-insulin diabetes and impaired glucose tolerance, for example, falls threefold between men who weighed 5.5 pounds at birth and those who weighed 9.5 pounds.7 These associations have been replicated in several different countries including the United States9 and India10 as well as in Britain. The associations are independent of adult ...
PMID: 24926663. Macdonald EM, Natale R, Regnault TR, Koval JJ, Campbell MK. Obstetric conditions and the placental weight ratio. Placenta. 2014 Aug;35(8):582-6. PMID: 24909371. Thompson JA, Piorkowska K, Gagnon R, Richardson BS, Regnault TR. Increased collagen deposition in the heart of chronically hypoxic ovine fetuses. J Dev Orig Health Dis. 2013 Dec;4(6):470-8. PMID: 24924226. Regnault TR, de Vrijer B, Galan HL, Wilkening RB, Battaglia FC, Meschia G. Umbilical uptakes and transplacental concentration ratios of amino acids in severe fetal growth restriction.Pediatr Res. 2013 May;73(5):602-11.PMID: 23407119. Kim-Fine S, Regnault TR, Lee JS, Gimbel SA, Greenspoon JA, Fairbairn J, Summers K, de Vrijer B. Male gender promotes an increased inflammatory response to lipopolysaccharide in umbilical vein blood.J Matern Fetal Neonatal Med. 2012 Nov;25(11):2470-4. PMID: 22506729. Thompson JA, Gros R, Richardson BS, Piorkowska K, Regnault TR. Central stiffening in adulthood linked to aberrant aortic ...
The focus of my research is in understanding the mechanisms that cause fetal growth restriction and drive fetal programming of adult disease.