Shimamura, T; Hashimoto, K; and Sasaki, S, Feedback suppression of the immune response in vivo. II. Involvement of prostaglandins in the generation of suppressor- -inducer b lymphocytes. (1982). Subject Strain Bibliography 1982. 2769 ...
Feedback Control Systems ( FCS ). Lecture-1 & 2 Introduction to the Subject. Dr. Imtiaz Hussain email: [email protected] URL : http://imtiazhussainkalwar.weebly.com/. Course Outline. Text Books. Modern Control Engineering, (5 th Edition) By: Katsuhiko Ogata. Slideshow 2395821 by onawa
Modelling Robust Feedback Control Mechanisms That Ensure Reliable Coordination of Histone Gene Expression with DNA Replication. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - GEN. T1 - A sensory feedback system utilizing cutaneous electrical stimulation for stroke patients with sensory loss. AU - Kita, Kahori. AU - Takeda, Kotaro. AU - Osu, Rieko. AU - Sakata, Sachiko. AU - Otaka, Yohei. AU - Ushiba, Junichi. PY - 2011/11/2. Y1 - 2011/11/2. N2 - Sensory disturbance is very common following stroke and may exacerbate a patients functional impairment, even if the patient has good motor function. For instance, patients with sensory disturbances will often grip an object with excessive or underestimated pinch pressure, because they do not receive the appropriate sensory feedback and must rely only on visual feedback. In this study, we developed a sensory feedback system that used cutaneous electrical stimulation for patients with sensory loss. In the system, electrical stimulation is modulated by the strength of pinch pressure and the patients are able to identify their fingertip pinch pressure. To evaluate the efficacy of the system, a clinical case study was ...
Objectives: Long chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes could be involved in this feed-back regulation.. Methods and Results: LC-MS analysis of conditioned media from isoproterenol-stimulated primary cultures of murine and human adipocytes demonstrated that most of the released non-esterified free fatty acids (NEFAs) are known agonists for FFAR4. In agreement with this, conditioned medium from isoproterenol-treated adipocytes stimulated signaling strongly in FFAR4 transfected COS-7 cells as opposed to non-transfected control cells. In transfected 3T3-L1 cells, FFAR4 agonism stimulated Gi- and Go-mini G protein binding more strongly than Gq - effects which were blocked by the selective FFAR4 antagonist AH7614. In primary cultures of murine white adipocytes, the synthetic, selective FFAR4 agonist CpdA inhibited isoproterenol-induced ...
A force feedback interface including a haptic accelerator that relieves the computational burden associated with force feedback generation from a force feedback processor. The force feedback processor is preferably a device microprocessor included in the interface device and separate from a controlling host computer for determining forces to be output. The haptic accelerator quickly determines velocity and/or acceleration information describing motion of a user manipulatable object from raw position data received from sensors of the interface device and representing the position of the user object. The velocity and/or acceleration data is used by the force feedback processor in the determination of forces to be output on the user object. The haptic accelerator can in some embodiments also quickly and reliably determine condition forces which depend on the motion of the user object, thus relieving additional computation burden from the force feedback processor and permitting the force feedback processor
The module introduces the topic of feedback control systems and presents methods of modelling that lead to transient, steady state and stability performances in control systems. An emphasis is placed on links between time responses and complex frequency domains. Principal topics are feedback systems, Bode, Nyquist and root-locus analysis, stability conditions and compensation design. The overall aim is to understand and be able to apply basic techniques for the analysis and design of feedback control systems.. ...
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In the physiology of the kidney, tubuloglomerular feedback (TGF) is a feedback system inside the kidneys. Within each nephron, information from the renal tubules (a downstream area of the tubular fluid) is signaled to the glomerulus (an upstream area). Tubuloglomerular feedback is one of several mechanisms the kidney uses to regulate glomerular filtration rate (GFR). It involves the concept of purinergic signaling, in which an increased distal tubular sodium chloride concentration causes a basolateral release of adenosine from the macula densa cells. This initiates a cascade of events that ultimately brings GFR to an appropriate level. The kidney maintains the electrolyte concentrations, osmolality, and acid-base balance of blood plasma within the narrow limits that are compatible with effective cellular function; and the kidney participates in blood pressure regulation and in the maintenance of steady whole-organism water volume Fluid flow through the nephron must be kept within a narrow range ...
A control system is a system, which provides the desired response by controlling the output. … Traffic lights control system is an example of control system. Here, a sequence of input signal is applied to this control system and the output is one of the three lights that will be on for some duration of time. ...
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Information retrieval is, in general, an iterative search process, in which the user often has several interactions with a retrieval system for an information need. The retrieval system can actively probe a user with questions to clarify the information need instead of just passively responding to user queries. A basic question is thus how a retrieval system should propose questions to the user so that it can obtain maximum benefits from the feedback on these questions. In this paper, we study how a retrieval system can perform active feedback, i.e., how to choose documents for relevance feedback so that the system can learn most from the feedback information. We present a general framework for such an active feedback problem, and derive several practical algorithms as special cases. Empirical evaluation of these algorithms shows that the performance of traditional relevance feedback (presenting the top K documents) is
Hey Jennie. I see your point of view and understand why it can be confusing. The reason wound healing is considered a positive feedback mechanism is because the output enhances the original stimulus. If a cut occurs, the body sends platelets and cells to the site. The platelets and cells fight invading pathogens and produce a clot. When the clot forms and the wound heals, the inflammation response and output end. Negative feedback changes a variable back to its original value and is constantly adjusting within the body. If your temperature is to high, a negative feedback loop works to lower it. If your temperature is low, it will bring it back up. Its a balancing act. Positive feedback only occurs in certain situations and has an ending, it does not constantly adjust. If you get a cut, a positive feedback loop works to heal it, then it stops. If you go into labor, the loop continues until you deliver, then its over and you go back to your original state. Think if you werent pregnant but felt ...
Hey Jennie. I see your point of view and understand why it can be confusing. The reason wound healing is considered a positive feedback mechanism is because the output enhances the original stimulus. If a cut occurs, the body sends platelets and cells to the site. The platelets and cells fight invading pathogens and produce a clot. When the clot forms and the wound heals, the inflammation response and output end. Negative feedback changes a variable back to its original value and is constantly adjusting within the body. If your temperature is to high, a negative feedback loop works to lower it. If your temperature is low, it will bring it back up. Its a balancing act. Positive feedback only occurs in certain situations and has an ending, it does not constantly adjust. If you get a cut, a positive feedback loop works to heal it, then it stops. If you go into labor, the loop continues until you deliver, then its over and you go back to your original state. Think if you werent pregnant but felt ...
As a process, apoptosis integrates a multitude of pro- and anti-cell death signals to a single decision for life or death. This type of all-or-none response to quantitative inputs is common in biological phenomena such as cell proliferation and differentiation and is often associated with a network topology containing positive feedback loops (28). While the ability of caspases to self-cleave provides one level of such feedback activity (17), we find that this feedback extends to cross activation between both the extrinsic and intrinsic pathways, with specific activation of either extrinsic or intrinsic apoptosis leading to near simultaneous activation of both caspase-8 and -9 in all apoptotic cells tested in this experiment. This supports a model wherein, although initiation of caspases is segregated by distinct pathways, an apoptotic signal, once having reached a threshold level, leads to a simultaneous activation across both arms of the apoptotic network. Several signaling mechanisms ...
Combined T(3)/T(4) therapy--In thyroidectomized patients, the L-T(4)-only replacement doses needed to normalize plasma T(3) or average tissue T(3) were 145 microg L-T(4)/day or 165 microg L-T(4)/day, respectively. The combined T(4) + T(3) dosing needed to normalize both plasma and tissue T(3) levels was 105 microg L-T(4) + 9 microg T(3) per day. For all three regimens, simulated mean steady-state plasma thyroid-stimulating hormone (TSH), T(3), and T(4) was within normal ranges (TSH: 0.5-5 mU/L; T(4): 5-12 microg/dL; T(3): 0.8-1.9 ng/mL). Parenteral T(4) administration--800 microg weekly or 400 microg twice weekly normalized average tissue T(3) levels both for subcutaneous (SC) and intramuscular (IM) routes of administration. TSH, T(3), and T(4) levels were maintained within normal ranges for all four of these dosing schemes (1x vs. 2x weekly, SC vs. IM). Central hypothyroidism--We simulated steady-state plasma T(3), T(4), and TSH concentrations in response to varying degrees of central ...
Tailored feedback was rated as more relevant, and was more likely to be shown to the GP than the generic feedback. Given that the tailored feedback included personalised risk factor information, it is not surprising that it was rated as more relevant. Almost two-thirds of participants given the tailored feedback indicated that they either showed the feedback to their GP or it gave them some ideas about what to ask the doctor, compared to less than half of those who received generic feedback. Anecdotally, the tailored feedback prompted a greater response from participants than the generic feedback, including several who were surprised by their recommended healthy weight, and one participant who commented that seeing her depression score prompted her to bring this up with her GP. However, participants did not rate the tailored feedback as any more likely to help them improve their health, or any easier to understand, than the generic feedback.. The type of feedback did not appear to influence ...
use CGI::Application::Plugin::Feedback :all; sub rm_one { my $self = shift; my $nextmode = (int rand 2) ? two : three; $self-,feedback(Hi there, as you call the feedback method with an string argument, ); $self-,feedback(it gets appended, stored in the session object.); $self-,feedback(When you ask feedback to be injected into a HTML Template, ); $self-,feedback( the feedback is shown and emptied from the session.); $self-,header_type(redirect); $self-,header_props(-url=,?rm=$nextmode); return Redirecting..; } sub rm_two { my $self = shift; my $tmpl = $self-,load_tmpl(undef, die_on_bad_params =, 0 ); $tmpl-,param( FEEDBACK =, $self-,get_feedback_prepped ); return $tmpl-,output; } # or how i like to code my runmodes... sub rm_three { my $self = shift; $self-,feedback(This is runmode three, hello there. ); return $self-,tmpl-,output; } sub tmpl { my $self = shift; unless ( defined $self-,{tmpl}){ $self-,{tmpl} = $self-,load_tmpl(undef, die_on_bad_params =, 0 ); ...
Feedback loops, both positive and negative are embedded in the Mitogen Activated Protein Kinase (MAPK) cascade. In the three layer MAPK cascade, both feedback loops originate from the terminal layer and their sites of action are either of the two upstream layers. Recent studies have shown that the cascade uses coupled positive and negative feedback loops in generating oscillations. Two plausible designs of coupled positive and negative feedback loops can be elucidated from the literature; in one design the positive feedback precedes the negative feedback in the direction of signal flow and vice-versa in another. But it remains unexplored how the two designs contribute towards triggering oscillations in MAPK cascade. Thus it is also not known how amplitude, frequency, robustness or nature (analogous/digital) of the oscillations would be shaped by these two designs. We built two models of MAPK cascade that exhibited oscillations as function of two underlying designs of coupled positive and negative
Taking a playcentric approach in a game-designing classroom might mean, as a student game designer, asking your classmates to play your game and give you feedback in a structured way. To get constructive feedback, you might ask your classmates to use sentence starters such as I like and I wonder and what if?. It also means learning how to listen and take on board their feedback or suggestions. These are examples of practices we saw in some of the primary and intermediate Games for Learning classrooms. By practising this process regularly, students got better at both giving and receiving thoughtful, constructive feedback. In one Year 7-8 classroom, students were facilitating the whole feedback process themselves, no longer needing the teacher to run it.. In a Year 6 classroom, in a different school, each student brainstormed as many ideas as they could for a game they would like to design. Then they took their ideas around the classroom on a speed date to get rapid feedback from peers. ...
Definition of feedback regulation in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is feedback regulation? Meaning of feedback regulation as a finance term. What does feedback regulation mean in finance?
This paper discusses the development of computer-based business simulations designed to prepare high school students for entry-level jobs in business, and explores the implementation of feedback mechanisms in simulations. Reasons why simulations are an appropriate type of media for this application, the nature of feedback, and research on feedback are considered. An overview of the Classroom, Inc. Project is then presented, including descriptions of the computer-based simulations and activities augmenting the simulation. The following instructional goals and ways that the goals are addressed by the simulations are examined: (1) give students experience with the language of the corporate world; (2) give students a feel for the major structural features of a business entity; (3) introduce students to contingencies in the business environment; and (4) show students how these contingencies are related to each other and to the goals of the business entity. The benefits of using fiction
In a mobile communication system, receivers measure channel characteristics using a received reference channel signal. The receivers determine a weight which has orthogonality with respect to each of a preset number of weight vectors in the mobile communication system and has the highest signal-to-interference-and-noise ratio, and feedback the weight and the corresponding signal-to-interference-and-noise ratio to the transmitter. The transmitter interprets the feedback information output from the receivers and determines receivers having feedback information which are orthogonal to each other and have the maximum throughput as an addition capacity when transmitted simultaneously, and determines weights based on the feedback information of the receivers having the maximum throughput. By applying the determined weights to the antennas using a well-known beam forming scheme, data can be transmitted to each of the determined receivers. Therefore, the
The distribution of motivations will be used (alongside other research, data, and feedback) to determine how to present and prioritize existing or non-existent features in this feedback system - including but not limited to: feedback input (here, star ratings on 4 metrics); feedback summary (here, bar graph for each metric); feedback output (potentially reviews, comments, messages to editors, lists, updates to profile pages, and on). Responses to this answer will also highlight areas where further research and design thinking needs to take place (for example, if we see a significant bias in motivations to opinion sharing we will further explore iterations on the interface or new interface elements that lead to a richer opinion sharing experience ...
318027337 - EP 2153025 A2 2010-02-17 - REAL TIME CLOSED LOOP INTERPRETATION OF TUBING TREATMENT SYSTEMS AND METHODS - [origin: WO2008152599A2] A technique facilitates the treatment of a subterranean formation. The technique involves the use of a fluid delivery system that comprises a continuous feedback system. The continuous feedback system utilizes a real time closed loop interpretation technique to instantaneously synchronize and adjust actions at a well site surface relative to measured downhole events. Sensors are used to monitor at least one downhole property in real time. Based on the real time data, the continuous feedback system enables adjustments to be made with respect to the at least one property in a manner designed to influence a downhole event.[origin: WO2008152599A2] A technique facilitates the treatment of a subterranean formation. The technique involves the use of a fluid delivery system that comprises a continuous feedback system. The continuous feedback system utilizes a real time
Despite this, it includes a pdf feedback with a different alignment. same Problem SolversMartin H. SchultzElliptic Problem Solvers enables pdf feedback same to some mistakes of the acid zero-offset of big auxiliary face deliveryArrives. abbreviated into 40 Methods, this pdf feedback systems inputoutput is with an type of the double access of Settling a general Galerkin example encoding functional easy essential reproductive women.
Julian Reschke, Mon, 28 Mar 2011 15:55:25 +0200: , On 28.03.2011 15:49, Sam Ruby wrote: ,, On 03/28/2011 09:18 AM, Julian Reschke wrote: ,,, On 28.03.2011 14:56, Sam Ruby wrote: ,,,, On 03/28/2011 08:44 AM, Julian Reschke wrote: ,,,,, ,,,,, PS: chairs, please consider this feedback when deciding on ISSUE-27. ,,,, ,,,, The poll is still open. Please take this opportunity to update your ,,,, responses as you see fit. Feel free to include a link to your email in ,,,, your response. ,,, ,,, This works for survey feedback on Change Proposals, but not for feedback ,,, on other peoples feedback. ,, ,, Why not? Others have done such in the past. When they have done so, ,, their feedback has been taken into consideration. ,, ... , , Im not sure how to do that. , , If I want to comment on a somebody else feedback on my own change , proposal, where do I put that? , , I note this WG has an issue tracker that tracks mailing list , discussions when labeled properly. We should take advantage of that. You ...
In rainbow trout, bilateral castration at any stage of the testicular cycle, including the, period when the testes are inactive, increases plasma GtH levels (Billard, Richard and Breton, 1.976, 1977; Billard, 1978a). These results indicate that the negative feedback action of testicular steroids on GtH secretion occurs at all stages in the breeding cycle. Sex steroids are taken up and sequestered in the pituitary, the NPO, the nucleus lateralis tuberis (NLT), the nucleus recessus lateralis and other locations in the brain in many species of fishes, suggesting that a number of sites in the brain can serve as loci for feedback action of sex steroids (Kim. et al., 1978; Peter and Crim, 1979). In the sexually mature female goldfish, serum GtH levels increase markedly following implantation of antiestrogens in the pituitary, whereas similar implants in the NLT area result only in a modest GtH increase and have no effect when implanted elsewhere (Billard and Peter, 1977). Thus the NLT and pituitary ...
The invention relates to a device for the representation and determination of the rigidity of materials, by means of which measured physical values can be represented at a vicinity distant from the place of measurement and above all by means of a tactile representation, in other words, using the sense of touch. According to the invention, a force feedback system has been developed which permits the user or operator to gain a feeling for the mechanical rigidity value. The value for rigidity, measured for example for medical purposes by endoscope or arthroscope, controls the pressure found in an external touch cushion (2), by means of one of the voltages (U), given by an analytical device recording the appropriate test region. The rigidity of the cushion (2) thus gives an equivalent feel to the measured rigidity of the material under evaluation, or the biological probe. In the above rigidity transmitter (1) a pressure (P) is generated in a closed pressure system by means of an input converter (3) and
Support Feedback = = Introduction = From time to time, issues or conflicts arise in support channels. We should have a documented process for listening to feedback and acting on it where possible. This document is oriented to irc support (specifically the #fedora support channel), but could be expanded to cover other support areas (mailing lists / forums). = Current #fedora feedback = The current method of feedback is via irc, in the #fedora-ops channel, and after that in email to the irc-support-operators group in fas. The current setup for feedback of support in #fedora has a number of problems: * Its not really documented at all. * Feedback is done right after events that raised the issue, so everyone is emotional and hot about it. * Both the person wanting to provide the feedback and possibly people they wish to provide feedback about are in all these avenues, possibly leading to back and forth and heated exchanges between them. * Since feedback is done directly, there is no way to just ...
In general, the prediction process is one of identifying the current state of the system, and making a prediction for some as yet uncomputed value based on that state. Prediction accuracy is improved by learning what is a good prediction for that state using a feedback process at the time the predicted value is actually computed. While there have been a number of efforts to formally characterize this process, we have taken the approach of providing a simple algebraic-style notation that allows one to express this state identification and feedback process. This notation allows one to describe a wide variety of predictors in a uniform way. It also facilitates the use of an efficient search technique called genetic programming, which is loosely modeled on the natural evolutionary process, to explore the design space. In this paper we describe our notation and the results of the application of genetic programming to the design of branch and indirect jump predictors. ...
Ready to ship: Within cells displaying features of Alzheimers, the researchers found high concentrations of WAVE1 and the amyloid-β precursor protein within the Golgi, an organelle in which proteins are packaged for shipping. These appear in the cell above as bright, yellow clusters.. Our discovery centers on a protein called WAVE1, which we found to be important in the production of amyloid-β. The reduction of WAVE1 appears to have a protective effect against the disease, says study author Paul Greengard, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience. When levels of amyloid-β rise, there is an accompanying increase in another molecule, AICD, which reduces the expression of WAVE1. This has the effect of reducing the production of amyloid-β.. By targeting steps within this newly discovered pathway, he adds, it may be possible to develop drugs to reduce amyloid-β that potentially could be used to either treat or prevent Alzheimers ...
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We introduce here a simple finite-dimensional feedback control scheme for stabilizing solutions of infinite-dimensional dissipative evolution equations, such as reaction-diffusion systems, the Navier-Stokes equations and the Kuramoto-Sivashinsky equation. The designed feedback control scheme takes advantage of the fact that such systems possess finite number of determining parameters (degrees of freedom), namely, finite number of determining Fourier modes, determining nodes, and determining interpolants and projections. In particular, the feedback control scheme uses finitely many of such observables and controllers. This observation is of a particular interest since it implies that our approach has far more reaching applications, in particular, in data assimilation. Moreover, we emphasize that our scheme treats all kinds of the determining projections, as well as, the various dissipative equations with one unified approach. However, for the sake of simplicity we demonstrate our approach in this
Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors Scientists demonstrated that neurogenin 3 (NEUROG3) is phosphorylated within the nucleus on serine 183, which catalyzes its hyperphosphorylation and proteosomal degradation. During progression through the progenitor cell cycle, NEUROG3 phosphorylation is driven by the actions of cyclin-dependent kinases 2 and 4/6 at G1/S cell-cycle checkpoint. [Dev Cell] Abstract , Graphical Abstract Prolonged Elimination of Negative Feedback Control Mechanisms along the Insulin Signaling Pathway Impairs β Cell Function In Vivo Investigators examined the effects of mutation of five inhibitory Ser phosphorylation sites on insulin receptor substrate 2 (IRS2) function in transgenic mice that overexpress, selectively in pancreatic β cells, either wild-type (WT) or a mutated IRS2 protein (IRS25A). Islets size, number, and mRNA levels of catalase and superoxide dismutase, were increased, while those of nitric ...
Background: Murine double minutes-2 (MDM2) protein plays a key role in physiological processes like growth arrest, senescence and apoptosis. MDM2 negatively regulates key proteins like p53 by inhibiting its transcriptional activity and promoting its proteosomal degradation through ubiquitinylation. In turn, the MDM2 expression is regulated in part by a p53-responsive promotor. This negative feedback control mechanism assures that both p53 and MDM2 are kept at very low levels in proliferating cells. However, in about half of all human tumors, the normal regulation of p53 might be disrupted through direct overexpression of MDM2 caused by e.g. MDM2 gene amplification or a T to G substitution (SNP309) in the promotor region of MDM2. High resolution melting analysis (HRMA) provides a valid approach to efficiently detect DNA mutations. The current study aimed at validating and implementing HRMA for screening of colorectal cancer patients (CRC) to detect MDM2 promotor SNP309. Pyrosequencing was used to ...
A process, apparatus, and method for online control and database collection and management of a computerized detection, tracking, and feedback control system. The system tests for nutrients by Raman scattering effects on skin or other tissues to determine the content of carotenoids or other nutrients as evidenced in that skin. Serum levels of nutrients may vary dramatically with time, but skin tissues may average such nutrition over time. Skin and other tissues may be scanned with light to produce accurate measurements of carotenoids or other nutrients accumulated in the skin based on the Raman scattering affect of those nutrients in the skin. A score can be derived from a properly calibrated bio-photonic scanner to reflect an averaged effective uptake of the detected nutrient (e.g. such as the carotenoid example).
Basically what im asking is that does it involve the hypothalamus or pituitary gland etc. as the control centre? (If it involves one). Is the message gone to there (CNS) where it comes back to say, the liver or pancreas to issue a response ...
The guidelines and suggestions from these resources are summarized in the following list of effective evaluation practices:. 1. Clearly communicate evaluation criteria to supervisees and develop a mutually agreed upon written contract reflecting these criteria.. 2. Identify and communicate supervisee strengths and weaknesses. The Ethical Guidelines for Counsellor Supervisors (ACES, 1993) recommend that supervisors provide supervisees with ongoing feedback on their performance. This performance feedback establishes for supervisees a clear sense of what they do well and which skills need to be developed. Supervisee strengths and weaknesses can be evaluated in terms of process, conceptual, personal, and professional skills (Bernard R Goodyear, 1992, p. 42).. 3. Use constructive feedback techniques during evaluations. Supervisees are more likely to hear corrective feedback messages when these are preceded by positive feedback, focussed on observable behaviours, and are delayed until a positive ...
The long-held concept of a proportional negative feedback control between the thyroid and pituitary gland requires reconsideration in the light of more recent studies. Homeostatic equilibria depend on dynamic interrelationships between thyroid hormones and pituitary thyrotropin (TSH). They display a high degree of individuality, thyroid-state-related hierarchy and adaptive conditionality. Molecular mechanisms involve multiple feedback loops on several levels of organization, different time scales and varying conditions of their optimum operation, including a proposed feedforward motif. This supports the concept of a dampened response and multistep regulation, making the interactions between TSH, FT4 and FT3 situational and mathematically more complex. As a homeostatically integrated parameter, TSH becomes neither normatively fixed nor a precise marker of euthyroidism. This is exemplified by the therapeutic situation with L-thyroxine (L-T4) where TSH levels defined for optimum health may not apply
Here at Meneage Dental, were lucky enough to receive some great feedback from patients following their treatments from our dentists, nurses and hygienists.. Sometimes we get letters of thanks and sometimes its just a brief comment on a feedback form as they leave - heres just a few of the latter - received over the last 30 days or so:. ...
A level biology students need to be able to explain the principles of homeostasis through detailed understanding of feedback systems. Students need to understand the importance of maintaining the internal environment within restricted limits and the implications of these conditions not being met.. They need to be able to explain what is meant by both negative and positive feedback, be able to explain the general stages in negative feedback and clearly articulate the differences between positive and negative feedback systems.. Regulation of temperature, pH and blood sugar levels are particular examples that students will be expected to describe and explain in detail.. Kidney function is often included within this topic area, with students required to know about the processes of ultrafiltration and reabsorption and to be able to explain the role of the loop of Henle and the counter current multiplier mechanism. This is often a difficult concept for students and does rely on a prior understanding ...
As university lecturers, we often struggle to provide our students with good quality feedback in a consistent manner. This is usually caused by the increasing imbalance in teacher-student ratios (Hounsell et al., 2008), as well as the pressure of academic life and the lack of time (Sadler, 2010). In addition, assessment practices should be transparent enough to ensure all students are evaluated in a similar way (ODonovan et al., 2004), especially when different instructors teach different groups of students taking the same course. This paper, which focuses on designing a feedback scheme that helps instructors to provide good quality feedback in a consistent manner, begins with a needs analysis based on the authors experience as an instructor of academic writing in English. A literature review follows, focusing on: (a) the scholarship on feedback in higher education; and (b) the research on the use of technology for the provision of feedback. Finally, a feedback scheme is presented, and some ...
In biological systems such as organisms, ecosystems, or the biosphere, most parameters must stay under control within a narrow range around a certain optimal level under certain environmental conditions. The deviation of the optimal value of the controlled parameter can result from the changes in internal and external environments. A change of some of the environmental conditions may also require change of that range to change for the system to function. The value of the parameter to maintain is recorded by a reception system and conveyed to a regulation module via an information channel. Biological systems contain many types of regulatory circuits, among which positive and negative feedbacks. Positive and negative dont imply consequences of the feedback have positive or negative final effect. The negative feedback loop tends to slow down a process, while the positive feedback loop tends to accelerate it. Feedback and regulation are self related. The negative feedback helps to maintain ...
As a reminder, the PQRS Feedback Reports reflect the existing PQRS requirements under current law except for the adjustment summary section. The adjustment summary section has been revised to reflect the CY 2018 MPFS proposed rule, which proposes to reduce the required number of reporting measures submitted for 2016 PQRS from nine to six.. The QRURs are based on the proposals in the 2018 MPFS proposed rule. CMS proposes to hold physicians harmless from downward payment adjustments from 2016 VBPM quality tiering if they satisfy the requirements for PQRS. If the policies are not finalized as proposed, CMS will provide updated reports to recipients. The final rule is expected to be released in early November.. To access your reports:. ...
Définitions de Positive feedback, synonymes, antonymes, dérivés de Positive feedback, dictionnaire analogique de Positive feedback (anglais)
A few things occur to me.. 1) I like the OP Davids idea and agree it would be a good to include some delay into the Feedback process when buyers are making a knee-jerk reaction and leaving neutral or negative. Clearly a seller should be informed of an issue and be given the right and time to make good. I have noticed that whilst rare, when I do get a poor comment or rating it is usually timed at about when the buyer has returned home from work (bad day in the office!) or around midnight (after the pub!). Upon receiving these I always contact the buyer (never immediately, let them calm down first!) and on most occasions the issue is quickly resolved to their complete satisfaction. So, what then to do about the Feedback rating or snotty comment…... 2) Well, having resolved the issue and pleased the buyer, one problem with the current system is a seller can not submit a Feedback Revision Request for a neutral rating or positive rating with a snotty comment (aka false positive). Well, depending ...
TY - JOUR. T1 - Feedback Control of an Achiral Robotic Microswimmer. AU - Kei Cheang, U.. AU - Kim, Hoyeon. AU - Milutinović, Dejan. AU - Choi, Jongeun. AU - Kim, Min Jun. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Magnetic microswimmers are useful for navigating and performing tasks at small scales. To demonstrate effective control over such microswimmers, we implemented feedback control of the three-bead achiral microswimmers in both simulation and experiment. The achiral microswimmers with the ability to swim in bulk fluid are controlled wirelessly using magnetic fields generated from electromagnetic coils. The achirality of the microswimmers introduces unknown handedness resulting in uncertainty in swimming direction. We use a combination of rotating and static magnetic fields generated from an approximate Helmholtz coil system to overcome such uncertainty. There are also movement uncertainties due to environmental factors such as unsteady flow conditions. A kinematic model based feedback ...
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We propose a knapsack-based feedback suppression algorithm for reliable multicast transport protocols operating over a satellite network. A reliable transp
Prior research on performance feedback has focused on the direct impact of performance feedback on risk taking (Lim & McCann, 2013) and paid little attention to the role of contextual factors. In particular, there are few empirical studies that examine how performance feedback and institutions interplay in risk taking of organizations. This study aims to fill this gap by investigating the role of organization-level institutional logics and state-level institutions in a microfinance industry. Institutions arise as a result of human beings continuous efforts to deal with uncertain environments (North, 1990; Scott, 1995). Thus, individual and organizational actors are affected by institutions, and different institutions can be a source of heterogeneity of organizational behavior (Peng, 2003). This suggests that the impact of performance feedback on risk taking can be affected by institutional factors. And, microfinance industry provides a good setting to investigate this issue.
TY - JOUR. T1 - IGF feedback effects on growth hormone secretion in ewes. T2 - Evidence for action at the pituitary but not the hypothalamic level. AU - Fletcher, T. P.. AU - Thomas, G. B.. AU - Dunshea, F. R.. AU - Moore, L. G.. AU - Clarke, I. J.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - The putative negative feedback effects of IGF-I and IGF-II on GH secretion were tested by intracerebroventricular (icv) and intrapituitary administration to sheep. Over two consecutive days, serial jugular blood samples were taken at 10 min intervals for 6 h from ewes n = 3/group) fitted with indwelling stainless steel cannulae into the lateral or third cerebral ventricles. The sheep were injected (icv) with either vehicle or purified ovine IGF-I (2, 4 or 8 μg). IGF-I injection had no effect on plasma GH secretion. Serial blood samples were taken from a second group of nine ewes in which ovine or recombinant human (rh) IGF-I was infused (2.5 μg/h for 2 h) into the third ventricle; once again, IGF-I failed to ...
A feedback control system is disclosed for use in processing signals employed in pulse transmittance oximetry. The signals are produced in response to light transmitted through, for example, a finger at two different wavelengths. Each signal includes a slowly varying baseline component representing the relatively fixed attenuation of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation produced by the changing blood volume and oxygen saturation within the finger. The signals are processed by the feedback control system before being converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The feedback control system includes a controllable offset subtractor (66), a programmable gain amplifier (68), controllable drivers (44) for the light sources (40, 42), and the microcomputer (16). The microcomputer (16) receives signals from the offset
Curry also introduces a potential paradox in her report when she emphasises natural variations. The magnitude of natural temperature variation are regulated by feedback processes and have physical causes. The climate sensitivity also involve such feedback processes. Any feedback process based on temperature will act on both natural and forced changes in the temperature. If such feedbacks result in pronounced natural temperature variations, they also imply that the climate sensitivity is high. Examples of such feedbacks include increased atmospheric humidity and reduced snow/ice cover. Processes involving clouds are more uncertain, but they too are likely to be affected by temperature (convection) and act to modify the climatic response.. Natural variations may arise from both variations in the climatic state (eg ENSO, NAO, and PDO) or from external causes, such as changes in the sun and volcanic eruptions. There are also feedbacks relevant to forced variation as well as internal variability ...
A dual feedback control system for a Class-D power circuit maximizes efficiency by controlling the magnitude and phase angle of the resonant load circuit using two separate feedback loops. The first feedback loop changes the value of a first variable capacitor in response to difference in magnitude between the actual load impedance and the desired load impedance. The second feedback loop changes the value of a second variable capacitor in response to the phase difference between the actual phase angle and the desired phase angle. In this way, the real and imaginary components of the load impedance are controlled so that the Class-D circuit is in tune, and hence efficiency is maximized, over a wide range of load impedances. The dual feedback control of the present invention may be advantageously employed in the ballast of an electrodeless HID lamp system.
By Sontag, Eduardo Veliz-Cuba, Alan; Laubenbacher, Reinhard; Jarrah, Abdul Salam ABSTRACT Feedback loops play an important role in determining the dynamics of biological networks. To study the role of negative feedback loops, this article introduces the notion of distance-to- positive-feedback which, in essence, captures the number of independent negative feedback loops in the network, a property inherent in the network topology. Through a computational study using Boolean networks, it is shown that distance-to-positive- feedback has a strong influence on network dynamics and correlates very well with the number and length of limit cycles in the phase space of the network. To be precise, it is shown that, as the number of independent negative feedback loops increases, the number (length) of limit cycles tends to decrease (increase). These conclusions are consistent with the fact that certain natural biological networks exhibit generally regular behavior and have fewer negative feedback loops ...
0038] Referring to, for example, FIG. 3C, in the exemplary embodiment, the motors 40, 42 may have suitable position feedback systems 50, 52. The position feedback systems 50, 52 may be non-invasive with respect to the isolated atmosphere in the transport chamber, as will be described below. The feedback system 50, 52 for motors 40, 42 may be generally similar to the feedback system 150, 152 shown in FIG. 6. The feedback systems 150, 152 for each rotor may be similar to each other and may generally incorporate sensors 150A, 150G, 1501 and target indexing to establish absolute and incremental rotational position, as well as radial or centered position of the rotor 140R, 142R. In alternate embodiments, the sensors 150A, 150G, 1051 may provide feedback information for any one or more of the absolute and incremental rotational position and the radial position. For example, the sensors 150A, 150G, 1501 may be electromagnetic sensors such as Hall effect sensor, or may be optical or other beam sensors. ...
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In this study, we demonstrated that there is a positive feedback regulation between gankyrin and Nrf2, which amplifies the antioxidant capability of HCC cells. Under oxidative stress, increased Nrf2 activity promotes the transcription of gankyrin and up-regulates gankyrin expression. Excess gankyrin competitively interrupted the association between Nrf2 and Keap1 and subsequently stabilized Nrf2 protein. This positive feedback regulation helps combat excessive intracellular ROS, which reduces oxidative stress-induced cell death, maintains mitochondrial stability, and further contributes to the tumorigenesis of HCC. This feedback regulation is similar to the correlation between p62/SQSTM1 and Nrf2, as Nrf2 regulates the expression of p62/SQSTM1 through ARE, and in turn p62/SQSTM1 binds to Keap1 and prevents Nrf2 degradation (Jain et al., 2010). Similar to the p62/SQSTM1 protein, the human gankyrin protein contains an ELKE motif between aa 21-24 and an ENKE motif between aa 201-204, which serves ...
Microglia, the brains resident macrophages, help to regulate brain function by removing dying neurons, pruning non-functional synapses, and producing ligands that support neuronal survival1. Here we show that microglia are also critical modulators of neuronal activity and associated behavioural responses in mice. Microglia respond to neuronal activation by suppressing neuronal activity, and ablation of microglia amplifies and synchronizes the activity of neurons, leading to seizures. Suppression of neuronal activation by microglia occurs in a highly region-specific fashion and depends on the ability of microglia to sense and catabolize extracellular ATP, which is released upon neuronal activation by neurons and astrocytes. ATP triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into adenosine by CD73, which is expressed on microglia as well as other brain cells. Microglial sensing of ATP, the ensuing
The data described above demonstrate a local PDE feedback regulation in cardiac myocytes whereby β1AR signals activate PDE4B3 via PKA-mediated phosphorylation. PKA-activated PDE4B, in turn, reduces the local steady-state cAMP concentration in a confined subsarcolemmal domain. The functional consequences of interrupting this feedback include increased PKA-mediated phosphorylation of Cav1.2 and RyR2, which is necessary for fine-tuning of ECC, a finding consistent with the cardiac phenotype of PDE4BKO mice (Leroy et al., 2011). Functional data on intracellular Ca2+ levels and contraction rate confirm the altered cAMP/PKA signaling in PDE4BKO myocytes. These conclusions are based on measurements of βAR-induced cAMP accumulation at the plasma membrane of PDE4BKO myocytes, the effects of acute PDE4B-selective inhibition in wild-type myocytes, the β1AR-dependent activation of PDE4B and the altered PKA-mediated phosphorylation of some, but not all substrates involved in Ca2+ homeostasis and ...
An aircraft user interface haptic feedback system includes a user interface, a position sensor, a cogless motor, and a control circuit. The user interface is movable to a position. The position sensor senses the position of the user interface and supplies a user interface position signal. The cogless motor is coupled to the user interface, and receives motor drive signals. The cogless motor, in response to the motor drive signals, supplies feedback force to the user interface. The control circuit receives at least the user interface position signal and a signal representative of the motor current and is operable, in response to at least these signals, to control the motor current supplied to the cogless motor using a non-trapezoidal motor commutation scheme.
0006] In the related art, the request from the mobile terminal is limited to requesting uplink bandwidth. Also, allocation of a Fast-feedback channel (e.g., CQICH) that allows quick transferring of various feedback values was received only based according to an allocation from the base station. When the base station requests feedback values upon allocation of a CQICH region to the mobile terminal, a CQICH_Enhanced_allocation Information Element (IE), a CQICH-allocation IE or if data exists, a Fast-feedback allocation sub-header is used for informing. Only the mobile terminal that received a request through such IE or sub-header then calculates the requested feedback value and reports such thereof. Accordingly, reporting a most recent downlink channel state (condition) value of the mobile terminal with a request from the base station, changing into MIMO mode for channel improvement (enhancement) in a multiple antenna system, and other such procedures cannot be requested from the mobile terminal ...
This study evaluates the addition of a quality improvement toolbox to an online audit and feedback intervention in Dutch intensive care units. The toolbox comprises for each quality indicator (e.g., percentage of patients per shift whose pain is measured) a list of potential bottlenecks in the care process (e.g., staff is unaware of the prevailing guidelines for measuring pain every shift), associated recommendations for actions to solve mentioned bottlenecks (e.g., organize an educational training session), and supporting materials to facilitate implementation of the actions (e.g., a slide show presentation discussing the importance and relevance of measuring pain every shift). Half of the participating intensive care units will only receive online feedback, while the other half will additionally gain access to the integrated toolbox to facilitate planning and executing actions ...
How children learn from positive and negative performance feedback lies at the foundation of successful learning and is therefore of great importance for educational practice. In this study, we used functional magnetic resonance imaging (fMRI) to examine the neural developmental changes related to feedback-based learning when performing a rule search and application task. Behavioral results from three age groups (8-9, 11-13, and 18-25 years of age) demonstrated that, compared with adults, 8- to 9-year-old children performed disproportionally more inaccurately after receiving negative feedback relative to positive feedback. Additionally, imaging data pointed toward a qualitative difference in how children and adults use performance feedback. That is, dorsolateral prefrontal cortex and superior parietal cortex were more active after negative feedback for adults, but after positive feedback for children (8-9 years of age). For 11- to 13-year-olds, these regions did not show differential feedback ...
TY - JOUR. T1 - Altered pulsatile and coordinate secretion of pituitary hormones in aging. T2 - Evidence of feedback disruption. AU - Veldhuis, J. D.. PY - 1997. Y1 - 1997. N2 - A novel thesis is that healthy aging of neuroendocrine axes is marked by disruption of orderly patterns of hormone release (1). This can be quantified by a recently validated approximate entropy statistic applied to 24-hour hormone profiles, e.g., luteinizing hormone (LH), and growth hormone (GH). Moreover, more subtle disturbances of feedback control are indicated by decreased conditional regularity or synchrony (higher cross-approximate entropy) within coupled axes, such as ACTH-cortisol, LH-testosterone, etc. Such alterations can precede any changes in mean serum hormone concentrations, thus highlighting an impact of age on the feedback control mechanisms that coordinate the flow of signaling information within a neuroendocrine axis or network.. AB - A novel thesis is that healthy aging of neuroendocrine axes is ...
The audit and feedback process comprises one or more cycles of establishing best practice criteria, measuring current practice, feeding back findings, implementing changes, and further monitoring. This chain is only as strong as its weakest link. Feedback effects can be weakened by information-intention gaps (feedback fails to convince recipients that change is necessary), intention-behaviour gaps (intentions are not translated into action), or behaviour-impact gaps (actions do not yield the desired effect on patient care).9 The success of national audit programmes depends on local arrangements that promote action as well as measurement.10. A synthesis of 65 qualitative evaluations proposed ways of designing audit programmes to better align with local capacity, identity, and culture and to promote greater changes in clinical behaviour.11 Healthcare organisations have finite capacity, so audit programmes should be designed so that they require less work, make best use of limited local resources, ...
The neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) mediates important brain functions and contributes to the pathophysiology and successful drug treatment of many common psychiatric disorders, especially depression. It is established that a key mechanism involved in the control of 5-HT neurones is feedback inhibition by presynaptic 5-HT autoreceptors, which are located on 5-HT cell bodies and nerve terminals. However, recent experiments have discovered an unexpected complexity of 5-HT neurone control, specifically in the form of postsynaptic 5-HT feedback mechanisms. These mechanisms have the physiological effects of 5-HT autoreceptors but use additional 5-HT receptor subtypes and operate through neural inputs to 5-HT neurones. A postsynaptic feedback system that excites 5-HT neurones has also been reported. This article discusses current knowledge of the pharmacology and physiology of these new found 5-HT feedback mechanisms and considers their possible contribution to depression
The neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) mediates important brain functions and contributes to the pathophysiology and successful drug treatment of many common psychiatric disorders, especially depression. It is established that a key mechanism involved in the control of 5-HT neurones is feedback inhibition by presynaptic 5-HT autoreceptors, which are located on 5-HT cell bodies and nerve terminals. However, recent experiments have discovered an unexpected complexity of 5-HT neurone control, specifically in the form of postsynaptic 5-HT feedback mechanisms. These mechanisms have the physiological effects of 5-HT autoreceptors but use additional 5-HT receptor subtypes and operate through neural inputs to 5-HT neurones. A postsynaptic feedback system that excites 5-HT neurones has also been reported. This article discusses current knowledge of the pharmacology and physiology of these new found 5-HT feedback mechanisms and considers their possible contribution to depression
This study uncovered a function of the dual specificity ERK MAP kinase phosphatase, MKP3, for the specification of mesenchymal progenitors in the somite sclerotome. We showed that Mkp3 was expressed in a twin-striped pattern, which closely matched the emergence of scleraxis transcripts along the anteroposterior somite edges (Fig. 1). This pattern suggested a link between the modulation of FGF signalling by MKP3 and scleraxis expression. We demonstrated that somitic expression of Mkp3 in the dorsal sclerotome was itself dependent on active ERK MAP kinase. This implied that FGF signalling in dorsal sclerotome cells is modulated by a negative feedback loop, which involves MKP3 and ERK MAP kinase. Indeed, we found that the levels of Mkp3 transcripts detected in response to FGF beads can cycle between extensive overexpression after a short exposure to complete loss of endogenous Mkp3 message after 24 hours (Fig. 3A-C; data not shown). We showed by western blot analysis that this dynamic response ...
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As part of our PowerVR Graphics SDK v3.2 release, were announcing a public developer support and feedback system for PowerVR Insider members.
Patient Feedback for Vein Specialists of Pittsburgh in Oakmont, PA. Doctor Valerie Drnovsek, MD & team cares about your health and your feedback! See what people are saying about us today. We are conveniently located at 333 Allegheny Ave, #200, Oakmont, PA 15139. Book an appointment online or call (412) 312-4666.
A system and method for providing tiered patient feedback for use in automated patient care is described. Physiological measures are analyzed. Each physiological measure is representative of at least one of measured and derived patient information recorded on a substantially continuous basis and was retrieved from one such patient care record to determine a patient status. Tiered feedback is provided to an individual patient responsive to the patient status.
Interactions between cells bearing oncogenic mutations and the surrounding microenvironment, and cooperation between clonally distinct cell populations, can contribute to the growth and malignancy of epithelial tumors. The genetic techniques available in Drosophila have contributed to identify important roles of the TNF-α ligand Eiger and mitogenic molecules in mediating these interactions during the early steps of tumor formation. Here we unravel the existence of a tumor-intrinsic-and microenvironment-independent-self-reinforcement mechanism that drives tumor initiation and growth in an Eiger-independent manner. This mechanism relies on cell interactions between two functionally distinct cell populations, and we present evidence that these cell populations are not necessarily genetically different. Tumor-specific and cell-autonomous activation of the tumorigenic JNK stress-activated pathway drives the expression of secreted signaling molecules and growth factors to delaminating cells, which ...
Complementation of Ah receptor deficiency in hepatoma cells: negative feedback regulation and cell cycle control by the Ah receptor
Gesture feedback techniques are discussed that provide prompt feedback to a user concerning the recognition of one or more gestures. The feedback may be employed to confirm to a user that a gesture is being correctly recognized. The feedback may alternately warn a user that a desired gesture is not being correctly recognized, thereby allowing the user to cancel the erroneous gesture before it is invoked
Background: The integration of body-worn sensors with mobile devices presents a tremendous opportunity to improve just-in-time behavioral interventions by enhancing bidirectional communication between investigators and their participants. This approach can be used to deliver supportive feedback at critical moments to optimize the attainment of health behavior goals. Objective: The goals of this systematic review were to summarize data on the content characteristics of feedback messaging used in diet and physical activity (PA) interventions and to develop a practical framework for designing just-in-time feedback for behavioral interventions. Methods: Interventions that included just-in-time feedback on PA, sedentary behavior, or dietary intake were eligible for inclusion. Feedback content and efficacy data were synthesized descriptively. Results: The review included 31 studies (15/31, 48%, targeting PA or sedentary behavior only; 13/31, 42%, targeting diet and PA; and 3/31, 10%, targeting diet only). All
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): thesis or use of any of the information contained in it must acknowledge this thesis as the source of the quotation or information. i For many people images are a medium preferable to text and yet, with the exception of star ratings, most formats for conventional computer mediated feedback focus on text. This thesis develops a new method of crowd feedback for designers based on images. Visual summaries are generated from a crowds feedback images chosen in response to a design. The summaries provide the designer with impressionistic and inspiring visual feedback. The thesis sets out the motivation for this new method, describes the development of perceptually organised image sets and a summarisation algorithm to implement it. Evaluation studies are reported which, through a mixed methods approach, provide evidence of the validity and potential of the new image-based feedback method. It is concluded that the visual feedback
This paper is concerned with the linear/nonlinear aeroelastic control of 2-D supersonic lifting surfaces. Its goal is to provide the feedback control mechanism enabling one to enlarge the flight envelope by increasing the flutter speed, and also to control the character, benign/catastrophic of the flutter instability boundary. Structural and aerodynamic nonlinearities are included in the aeroelastic governing equations, and linear and nonlinear feedback controls in both plunging and pitching are employed in conjunction with proportional velocity feedback controls. The attention of the paper is focused on multiple Hopf bifurcations. In particular, the jumping phenomenon found in our previous work will be further investigated to reveal the physical implications. It is found that such a jumping occurs when the system has multiple families of limit cycles bifurcating from a same set of parameter values with multiple solutions for frequencies. The case investigated in this paper is restricted to zero ...
The T-cell receptor (TCR) signalling machinery is central in determining the response of a T cell (establishing immunity or tolerance) following exposure to antigen. This process is made difficult by the narrow margin of self and non-self discrimination, and by the complexity of the genetic programmes that are induced for each outcome. Recent studies have identified novel negative feedback mechanisms that are rapidly induced by TCR engagement and that have key roles in the regulation of signal triggering and propagation. In vitro and in vivo data suggest that they are important in determining ligand discrimination by the TCR and in regulating signal output in response to antigen.
Written feedback will be given for tutorial work within a week. Written and/or oral feedback for workshops will be given either during the sessions or within a week. Written feedback will be provided on all summative practical work within 20 working days. Closed exam results with per-question breakdown are returned to the students via supervisors within 5 weeks (as per special approval by the University Teaching Committee). Outline answers are made available via the Chemistry web pages when the students receive their marks, so that they can assess their own detailed progress/achievement. The examiners reports for each question are made available to the students via the Chemistry web pages.. ...
Signaling in development is not always on or off; often, distinct intensity and duration of signaling leads to distinct outcomes. This is true for receptor tyrosine kinase (RTK) signaling in many contexts, where negative feedback often plays a role. Although such negative feedback might reduce or even turn off signaling output over time, continued signaling is often maintained for proper cell fate specification. In this issue, Sieglitz et al. identify a positive regulator of Ras-mediated RTK signaling that they name Rau. Rau is necessary to achieve specific signaling intensity for the differentiation of photoreceptors and of glia that wrap axons in the developing Drosophila eye disc. Both the negative regulator Sprouty and Rau influence signaling through the guanosine triphosphatase Ras; specifically, Rau forms a positive feedback loop important for counteracting the Sprouty negative feedback loop.. ...
Weve demonstrated the effectiveness of our protocol in a pilot study, and now were moving on to the next stage comprising a crossover clinical study with about 50 dialysis patients, says Chait, an expert on robust feedback control design. What we hope to show is that the demonstrated success with the pilot project translates to similar success with the larger study. This study is a much stronger test of the efficacy and safety of our protocol.. In dialysis patients the amount of EPO produced by the kidneys is inappropriately low for the level of anemia, and so they are treated with recombinant human EPO hormone in order to minimize the need for blood transfusions. Chait notes that current anemia management protocols for administering EPO are more or less one size fits all and fail to achieve the desired outcomes for many patients. That is where Chaits expertise comes in. By utilizing the principles of feedback control systems, his protocols enable medical personnel to personalize the EPO ...
The student feedback forms have, in essence, been a system of feedback that has been hit-and-miss with the students. On the one hand you have a system that tries to incorporate a flimsy notion of student rights whilst on the other hand you have a system that more often than not seems too distant from the student. The recent complaints directed at the feedback system, due to the delays in the publication of results, shows how certain shortcomings have limited the impact of the system at large.. Firstly it must be pointed out that with regard to the publication of results it is the lecturers who have the right of this issue. In a collective agreement made with the lecturers (which is in the process of being renegotiated), they are allowed to give in results by the end of March however truth be told this agreement is of suspect legal impact since no sanctions per se are highlighted for any breaches.. ...
In order to be successful, millennial leaders need regular, useful, and frequent feedback into their performance. Here are 5 reasons why thats so, according to one leadership consultant.
Download SPINA for free. Structure parameter inference approach for endocrine feedback control. SPINA is software for determining constant structure-parameters of endocrine feedback control systems from hormone levels obtained in vivo. The first version of this cybernetic approach allows for evualuating the functional status of the thyroid gland, i.e.
When a query is commenced, the query is resolved as a similarity search by a couple of search engines (including AltaVista, Excite, etc.). The Web assistant then collects the top n (60 for the prototype) documents returned and groups them into clusters. What differs here from the Scatter/Gather by [4] is that the feedback of relevant clusters and the documents are not only gathered for clustering again but the query is modified for better formulating the information needed.. As we mentioned earlier, relevance feedback has long been suggested as a solution for query modification. Rocchio describes an elegant approach and shows how the optimal vector space query can be derived using vector addition and subtraction given the relevant and non-relevant documents [6]. The probabilistic model proposed by Robertson and Sparck Jones shows how to adjust the individual term weight based on the distribution of the terms in relevant and non-relevant document set [5].. Now, given the cluster or concept as ...
Thalamic activity is regulated by corticothalamic feedback from layers 5B and 6. The nature of these feedback systems differs, one difference being that whereas layer 5 provides driver input, the layer 6 input is thought to be modulatory. To selectively study the importance of the layer 6 corticothalamic (L6 CT) projection, a transgenic mouse line was used in which layer 6 cells projecting to posterior medial thalamus (POm) were targeted for expression of channelrhodopsin-2 and in vivo electrophysiology recordings were done in urethane-anaesthetized mice. […]. Read More… ...
Thanks for this post, Matthew. This got me thinking a lot. For me, the difference between a tutoring session and a course is like that of a short story and a novel. In the session, I am making sure every moment and move matters. I feel the need to understand the assignment and writer as quickly as possible, make strategic choices about what to cover and how deeply, and get straight to the point. I am much more direct. I also cling to the prompt much more because I dont know if the instructor/ professor likes surprises and also because as an outside reader I feel thats one of my uses- I can usually see when something is going off track or not following directions. As a teacher, I think I spend a lot of time getting to know students and building a relationship with them. I comment mostly on ideas and logics that one might see as big picture concerns. And I deliberately write assignments to be open ended so that I am surprised. As I tutor I want the assignment and the prompt to match, in other ...
Additionally, for the majority of phosphorylation sites identified on the CD3γδζ subunits, we observed a gradual decrease in Zap-70 null/reconstituted SILAC ratios at early time points, followed by a gradual increase in Zap-70 null/reconstituted SILAC ratios at later time points (Fig. 7E2). These trends are consistent with the hypothesis of competing positive and negative feedback loops functioning at different stages of stimulation. At early time points, positive feedback mechanisms could be regulating these sites, leading to a gradual decrease in Zap-70 null/reconstituted SILAC ratios. At later time points, negative feedback mechanisms could be regulating these same sites, leading to an increase in Zap-70 null/reconstituted SILAC ratios when Zap-70 is removed (Fig. 7E1). It has previously been shown that Erk positive and SHP-1 negative feedback pathways can compete to either activate or inhibit Lck function to allow for T cells to discriminate between self and foreign ligands (47).. To ...
As I said, I agree (for arguments sake) that the positive feedback loop is essential for switching the climate-systems between cold and warm states that are relative stable (i.e. ice-ages and interglacials). However, the positive feedback loop predominates only during the transition between states. Within each relatively stable state negative feedback must predominate or else stability would not be maintained. And today we find ourselves in just such a stable, negative feedback-dominated state in which climatic stability and equilibrium are maintained dynamically by the systems intrinsic negative feedback mechanism. In this state any global warming that occurs will be arrested automatically by the dominant negative feedback mechanism so that the default equilibrium temperature of the system is maintained within relatively narrow bounds. I think this by itself explains why no-one can find the tropospheric hotspot, regardless of any problems over our techniques of scientific measurement and the ...
The period (per) gene likely encodes a component of the Drosophila circadian clock. Circadian oscillations in the abundance of per messenger RNA and per protein (PER) are thought to arise from negative feedback control of per gene transcription by PER. A recently identified second clock locus, timeless (tim), apparently regulates entry of PER into the nucleus. Reported here are the cloning of complementary DNAs derived from the tim gene in a two-hybrid screen for PER-interacting proteins and the demonstration of a physical interaction between the tim protein (TIM) and PER in vitro. A restricted segment of TIM binds directly to a part of the PER dimerization domain PAS. PERL, a mutation that causes a temperature-sensitive lengthening of circadian period and a temperature-sensitive delay in PER nuclear entry, exhibits a temperature-sensitive defect in binding to TIM. These results suggest that the interaction between TIM and PER determines the timing of PER nuclear entry and therefore the duration ...
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Negative feedback is often referred to as shunt feedback and here in this application we will use it in conjunction with emitter degeneration. How is this accomplished? Negative feedback or shunt feedback is accomplished by adding one resistor and a capacitor between collector and base of our transistor. For this exercise Im going to go to an r.f. application and replace a resistor with a choke, it could easily have been a transformer
A previous article on the integrative modelling of Parkinsons disease (PD) described a mathematical model with properties that suggested that PD pathogenesis is associated with a feedback-induced biochemical bistability. In this article we show that the dynamics of the mathematical model can be extracted and distilled into an equivalent 2-state feedback motif whose stability properties are controlled by multi-factorial combinations of risk factors and genetic mutations associated with PD. Based on this finding, we propose a principle for PD pathogenesis in the form of the switch-like transition of a bistable feedback process from healthy homeostatic levels of reactive oxygen species and the protein α-synuclein, to an alternative disease state in which concentrations of both molecules are stable at the damagingly high levels associated with PD. The bistability is analysed using the rate curves and steady-state response characteristics of the feedback motif. In particular, we show how a ...
SPINA is software for determining constant structure-parameters of endocrine feedback control systems from hormone levels obtained in vivo. The first version of this cybernetic approach (SPINA Thyr) allows for evaluating the functional status of the thyroid gland, i.e. thyroids secretory capacity (SPINA-GT) and sum activity of peripheral deiodinases (SPINA-GD). Additional structure parameters that are calculated include Jostels TSH index and TTSI. ...