2019 Elsevier Ltd A statement on measuring blood omega-3 long chain polyunsaturated fatty acid levels was developed and edited based on input from ISSFAL members and accepted by vote of the ISSFAL Board of Directors. Summary of Statement: Omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) levels at baseline and post-intervention should be assessed and reported in future research to evaluate the efficacy of n-3 LCPUFA supplementation: b ecause; 1. there are numerous factors that affect n-3 LCPUFA levels in humans as described in the systematic literature review [1]; 2. assessing intake of n-3 LCPUFA from the diet and/or supplements is not sufficient to accurately determine n-3 LCPUFA levels in humans; 3. some studies do not provide sufficient doses of n-3 LCPUFA to produce a significant impact on bloodstream/organ content and there is substantial variability in the uptake of n-3 LPCUFA into tissues between individuals. In secondary analyses, clinical trials should consider the influence ...
TY - JOUR. T1 - Maternal long chain polyunsaturated fatty acid status is associated with child growth. AU - Mulhern, Maria S.. AU - Yeates, Alison. AU - McSorley, E. M.. AU - Wallace, J. M. W. AU - Myers, G. J. AU - Davidson, P. W. AU - Thurston, S. W.. AU - Shamlaye, C. F.. AU - Henderson, J.. AU - Watson, G. E.. AU - van Wijngaarden, E.. AU - Strain, JJ. PY - 2013/1. Y1 - 2013/1. M3 - Article. VL - 72. SP - OCE2. JO - Proceedings of the Nutrition Society.. JF - Proceedings of the Nutrition Society.. SN - 0029-6651. ER - ...
TY - JOUR. T1 - Polyunsaturated fatty acid levels in maternal erythrocytes of japanese women during pregnancy and after childbirth. AU - Kawabata, Terue. AU - Kagawa, Yasuo. AU - Kimura, Fumiko. AU - Miyazawa, Teruo. AU - Saito, Shoji. AU - Arima, Takahiro. AU - Nakai, Kunihiko. AU - Yaegashi, Nobuo. PY - 2017/3/7. Y1 - 2017/3/7. N2 - Background: The transport of polyunsaturated fatty acids (PUFAs), such as arachidonic acid (ARA, 20:4n‐6) and docosahexaenoic acid (DHA, 22:6n‐3), to the fetus from maternal stores increases depending on the fetal requirements for PUFA during the last trimester of pregnancy. Therefore, maternal blood PUFA changes physiologically with gestational age. However, the changes in PUFA levels in maternal blood erythrocytes during pregnancy and after childbirth have not been fully investigated in a fish‐eating population. Objective: To examine the changes of ARA and DHA levels in maternal erythrocytes with the progress of pregnancy and the relationship between ...
Chong, Foong Foong Mary, Ong, Yi Lin, Calder, Philip C., Colega, Marjorelee, Wong, X.Y. Jocelyn, Tan, Chuen Seng, Lim, Ai Lin, Fisk, L. Helena, Cai, Shi Rong, Pang, Wei Wei, Broekman, Birit F.P., Saw, Seang Mei, Kwek, Yung Chiang Kenneth, Godfrey, Keith M, Chong, Yap Seng, Gluckman, Peter D., Meaney, Michael Joseph, Chen, Yu Helen (2015-07-01). Long-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: Results from the GUSTO study. Journal of Clinical Psychiatry 76 (7) : e848-e856. [email protected] Repository. https://doi.org/10.4088/JCP. ...
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Purpose: AMD is the primary cause of blindness in elderly individuals of industrialized countries. Clinical studies have indicated that dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) may have a protective effect against AMD. This study characterizes the effects of dietary intake of ω-3 and ω-6 LCPUFAs in a mouse model of AMD.. Methods: The present studies adhered to ARVOs Statement for the Use of Animals in Ophthalmic and Vision Research. C57BL/6 mice were fed a diet enriched with either ω-3 or ω-6 LCPUFAs for 2 weeks prior to choroidal neovascularization (CNV) induction by photocoagulation using a 532-nm laser. CNV development was evaluated by FA, SD-OCT, and choroidal flatmount (CFM). The primary eicosanoids and their downstream metabolites were analyzed by LC MS/MS lipidomics. Expression of ICAM-1, E-selectin, and VEGF in the retina, choroid, or laser-captured CNV were evaluated by RTPCR and immunoblot analysis. Macrophage invasion was evaluated in Cx3cr1GFP/+ ...
The present invention includes a solid fat composition that includes an oil having saturated fat and a microbial oil having a long chain polyunsaturated fatty acid and an emulsifier. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low amounts of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions. The present invention also includes a microbial oil product prepared by extracting an oil-containing fraction comprising at least one LC-PUFA from a microbial biomass, and treating the fraction by a process of vacuum evaporation, wherein the oil product has not been subject to one or more of a solvent winterization step, a caustic refining process, a chill filtration process, or a bleaching process.
The present study, registered at clinicaltrials.gov with the unique registration number NCT00560014, sought to evaluate the relations between fatty acid concentrations in red blood cells or plasma and amino acid concentrations in plasma on rejection, calcineurin inhibitor toxicity, and new-onset diabetes mellitus.Lipid profiles on plasma or red blood cell samples were performed preoperatively and postoperatively in 54 patients. Plasma amino acid profiles were obtained in 49 of these patients.High concentrations of total omega-3 fatty acids, eicosapentaenoic and docosahexaenoic acids in red blood cells, and ornithine in plasma, all were associated with a significantly lower incidence of rejection, whereas high total omega-6 fatty acids were associated with a high rejection rate. Calcineurin inhibitor toxicity was associated with low levels of docosahexaenoic acid, ornithine, and the omega-3 index, and high total omega-6 and omega-3/omega-6 ratios. Inhibition of new-onset diabetes mellitus was ...
PubMed journal article S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimers diseas were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Wang, Qin; Würtz, Peter; Auro, Kirsi; Mäkinen, Ville-Petteri; Kangas, Antti J.; Soininen, Pasi; Tiainen, Mika; Tynkkynen, Tuulia; Jokelainen, Jari; Santalahti, Kristiina; Salmi, Marko; Blankenberg, Stefan; Zeller, Tanja; Viikari, Jorma; Kähönen, Mika; Lehtimäki, Terho; Salomaa, Veikko; Perola, Markus; Jalkanen, Sirpa; Järvelin, Marjo-Riitta; Raitakari, Olli T.; Kettunen, Johannes; Lawlor, Debbie A.; Ala-Korpela, Mika ...
The study was published in Journal of the American Heart Association. In the Cardiovascular Health Study in the USA, 3,660 people aged 65 and older underwent brain scans to detect so called silent brain infarcts, or small lesions in the brain that can cause loss of thinking skills, dementia and stroke. Scans were performed again five years later on 2,313 of the participants. Research shows that silent brain infarcts, which are only detected by brain scans, are found in about 20% of otherwise healthy elderly people. The study found that those who had high long-chain omega-3 polyunsaturated fatty acid content in blood had about 40% lower risk of having small brain infarcts compared to those with low content of these fatty acids in blood. The study also found that people who had high long-chain omega-3 polyunsaturated fatty acid content in blood also had fewer changes in the white matter in their brains. Previously in this same study population, similar findings were observed when comparing those ...
Background Long-chain polyunsaturated fatty acids (LCPUFAs) reduce T-cell activation and dampen inflammation. They might thereby counteract the neonatal immune activation and hamper normal tolerance development to harmless environmental antigens. We investigated whether fatty acid composition of cord serum phospholipids affects allergy development up to age 13 years. Methods From a population-based birth-cohort born in 1996/7 and followed until 13 years of age (n = 794), we selected cases with atopic eczema (n = 37) or respiratory allergy (n = 44), as well as non-allergic non-sensitized controls (n = 48) based on diagnosis at 13 years of age. Cord and maternal sera obtained at delivery from cases and controls were analysed for proportions of saturated, monounsaturated and polyunsaturated fatty acids among serum phospholipids. Results The cord serum phospholipids from subject who later developed either respiratory allergy or atopic eczema had significantly higher proportions of 5/8 LCPUFA species, as
Scientists at the University of Bristol have taken the first steps towards producing a sustainable and pure source of the healthy fats found in oily fish.. Eating such fish is encouraged as part of a healthy diet as their oils are rich in very long chain polyunsaturated fatty acids (VLCPUFAs). However, views on the health-promoting nature of VLCPUFAs have to be balanced against the marine pollution that can cause fish, and the oils extracted from them, to be contaminated with heavy metals and dioxins, and the fact that fish stocks are in global decline.. In work published in Nature Biotechnology in June, University of Bristol scientists and collaborators describe the first steps towards producing VLCPUFAs in the form of oilseed crop plants. By adding three genes to the genome of Arabidopsis thaliana (the roadside weed known as thale cress) the researcher produced plants with a substantial content of the valuable VLCPUFAs arachidonic acid (AA) and eicosapentaenoic acid (EPA), both of which are ...
Long-Chain Polyunsaturated Fatty Acids (LCPs) are produced by the conversion of Alpha-linolenic acids (ALAs) and linoleic acids in the...
Background: The incidence of allergic diseases in industrialized countries has increased, and a relation between allergy and dietary fatty acids has been proposed. Modulation of the maternal immune function during pregnancy may have an impact on future clinical outcome in the child.Aim: The aim of this thesis was to add knowledge on the relationship between long chain polyunsaturated fatty acids, sensitization and allergic disease and possible immunological events regulating this.Subjects: The thesis is based on results obtained from two cohorts. The first, including 300 cord blood samples collected from 1985-2005. The second, a double-blind placebo controlled multi-centre study comprising 145 families with allergic disease.Methods: Phospholipid fatty acids and total IgE antibodies were analyzed in cord blood samples with gas chromatography and Uni-CAP™, respectively.The families participating in the double-blind placebo controlled multi-centre study were recruited at antenatal units in ...
Background : The last trimester of pregnancy is a period of rapid accretion of long-chain polyunsaturated fatty acids, both in the central nervous system and the body as a whole. Human milk contains these fatty acids, whereas some preterm infant formulas do not. Infants fed formulas without these fatty acids have lower plasma and erythrocyte...
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The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids. The lipid composition is a major determinant of the membrane flexibility and sperm motility required for proper fertilization. It also influences the sperm plasma membranes fluidity, chilling sensitivity and thermotropic lipid phase transition (LPT) and these parameters determine our ability to cryopreserve these cells. Our hypotheses is that by providing dietary supplementation of omega-3 polyunsaturated fatty acids an improvement of sperm parameters (number, motility, viability) can be achieved. We also expect alteration spermatozoal plasma membrane fatty acid composition, making it more chilling resistant.. Experimental methodology: 1) Characterize fatty acid composition of the spermatozoa of normal and abnormal spermatozoa by gas chromatography. 2) Characterize sperm plasma membrane LPT by FTIR spectrometer. 3) Run a randomized double-blind, ...
PubMed journal article The capacity for long-chain polyunsaturated fatty acid synthesis in a carnivorous vertebrate: Functional characterisation and nutritional regulation of a Fads2 fatty acyl desaturase with Δ4 activity and an Elovl5 elongase in striped snakehead (Channa striata were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
XIANG, M., HARBIGE, L. S. and ZETTERSTRÖM, R. (2005), Long-chain polyunsaturated fatty acids in Chinese and Swedish mothers: Diet, breast milk and infant growth. Acta Paediatrica, 94: 1543-1549. doi: 10.1080/08035250500251601 ...
Harden, Charlotte Jane (2012) n-3 Long-Chain Polyunsaturated Fatty Acids, Appetite Control and Weight Management. PhD thesis, University of Sheffield. ...
The importance of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) for human health has received more focus the last decades, and the global consumption of n-3 LC-PUFA has increased. Seafood, the natural n-3 LC-PUFA source, is harvested beyond a sustainable capacity, and it is therefore imperative to develop alternative n-3 LC-PUFA sources for both eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). Genera of algae such as Nannochloropsis, Schizochytrium, Isochrysis and Phaedactylum within the kingdom Chromista have received attention due to their ability to produce n-3 LC-PUFAs. Knowledge of LC-PUFA synthesis and its regulation in algae at the molecular level is fragmentary and represents a bottleneck for attempts to enhance the n-3 LC-PUFA levels for industrial production. In the present review, Phaeodactylum tricornutum has been used to exemplify the synthesis and compartmentalization of n-3 LC-PUFAs. Based on recent transcriptome data a co-expression network of 106
TY - JOUR. T1 - Do fatty acids influence functions of intestinal dendritic cells?. AU - Kanai, Takanori. AU - Watanabe, Mamoru. PY - 2006/3. Y1 - 2006/3. UR - http://www.scopus.com/inward/record.url?scp=39049192870&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=39049192870&partnerID=8YFLogxK. U2 - 10.1007/s00535-006-1779-0. DO - 10.1007/s00535-006-1779-0. M3 - Comment/debate. C2 - 16699866. AN - SCOPUS:39049192870. VL - 41. SP - 288. EP - 289. JO - Journal of Gastroenterology. JF - Journal of Gastroenterology. SN - 0944-1174. IS - 3. ER - ...
TY - JOUR. T1 - Arachidonic acid increases intracellular calcium in erythrocytes. AU - Soldati, Laura. AU - Lombardi, Cinzia. AU - Adamo, Donatella. AU - Terranegra, Annalisa. AU - Bianchin, Cristiana. AU - Bianchi, Giuseppe. AU - Vezzoli, Giuseppe. PY - 2002. Y1 - 2002. N2 - Recently, we have measured in erythrocytes a voltage-modulated and dihydropyridine-inhibited calcium influx. Since arachidonic acid and other polyunsaturated fatty acids influence the activities of most ion channels, we studied their effects on the erythrocyte Ca2+ influx. It was measured on fresh erythrocytes, isolated from healthy donors, using the fluorescent dye Fura 2 as indicator of [Ca2+]i. AA (5-50 μM) and EPA (20-30 μM) stimulated a concentration-dependent increase in [Ca2+]i, deriving from extracellular calcium (1 mM), without affecting the intra- and extracellular pH and membrane voltage. The Ca2+ influx rate varied from 0.5 to 3 nM Ca2+/s in the presence of AA and from 0.9 to 1.7 nM Ca2+/s with EPA. The Ca2+ ...
Background: There is an increasing drive to replace fish oil (FO) in finfish aquaculture diets with vegetable oils (VO), driven by the short supply of FO derived from wild fish stocks. However, little is known of the consequences for fish health after such substitution. The effect of dietary VO on hepatic gene expression, lipid composition and growth was determined in Atlantic salmon (Salmo salar), using a combination of cDNA microarray, lipid, and biochemical analysis. FO was replaced with VO, added to diets as rapeseed (RO), soybean (SO) or linseed (LO) oils. Results: Dietary VO had no major effect on growth of the fish, but increased the whole fish protein contents and tended to decrease whole fish lipid content, thus increasing the protein:lipid ratio. Expression levels of genes of the highly unsaturated fatty acid (HUFA) and cholesterol biosynthetic pathways were increased in all vegetable oil diets as was SREBP2, a master transcriptional regulator of these pathways. Other genes whose ...
This topic has 14 study abstracts on Polyunsaturated Fatty Acids (PUFAs) indicating that it may have therapeutic value in the treatment of Cognitive Decline/Dysfunction, Alzheimers Disease, and Amyotrophic Lateral Sclerosis
This topic has 14 study abstracts on Polyunsaturated Fatty Acids (PUFAs) indicating that it may have therapeutic value in the treatment of Cognitive Decline/Dysfunction, Alzheimers Disease, and Amyotrophic Lateral Sclerosis
In view of the reported potential anti-inflammatory activity of the New Zealand green lipped mussel (NZGLM), we aimed to compare the effect of low dose marine oil supplementation, from mussels and fish, in reducing blood markers of inflammation. Thirty apparently healthy males and females were recruited from the general public in Melbourne, Australia to participate in a double blind, randomised, parallel intervention study. Subjects were consuming approximately 73 mg of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) daily in their background diet prior to the commencement of the intervention. Subjects were randomly assigned to consume either 2 mL/day of the NZGLM oil preparation (mixed with olive oil and dl-alpha-tocopherol) or fish oil preparation (also mixed with olive oil and dl-alpha-tocopherol) for six weeks. Two mL of the oils contained 241 mg and 181 mg of n-3 LCPUFA, respectively. Neutrophil phospholipid fatty acids, serum thromboxane B2 (TXB2), stimulated monocyte ...
There are many brands and forms of omega-3 polyunsaturated fatty acids available. Not all brands are listed on this leaflet. Omega-3 polyunsaturated fatty acids are used together with diet and exercise to help lower triglyceride levels in the blood. It is not known if omega-3 polyunsaturated fatty acids will prevent a...
Healthy African American and Caucasian persons will be screened for specific differences in genes that control how fats are processed in the body. Persons with the needed genotypes will be added to a database of healthy persons who may be asked to join a larger study comparing differences in diet on lipid metabolism and inflammatory biomarkers as well as future studies. A key hypothesis for the larger study is that variations in genes involved in lipid metabolism play a role in determining levels of long chain polyunsaturated fatty acids (LC-PUFAs ...
Examples of unsaturated fatty acids are oleic acid, alpha-linolenic acid and linoleic acid. They are present in both plant and animal sources of food.
Ruxton, C.H.S., Calder, P.C., Reed, Stephen C. and Simpson, J.A. (2005) The impact of long-chain n-3 polyunsaturated fatty acids on human health. Nutrition Research Reviews, 18 (1). pp. 113-129. ISSN 0954-4224 Full text not available from this repository ...
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My research interests are in the area lipid metabolism. I am currently involved in a project where we investigate if supplementation with long chain polyunsaturated fatty acids (LC-PUFAs) can reduce frequency and severity of the eye disease Retinopathy of prematurity (ROP) in very preterm infants. My role in the project is to analyze the composition of fatty acids and other lipids in serum from the preterm infants. I am also involved in a metabolomics study aimed at identifying molecular markers associated with ROP ...
Elecare Lcp Pwd 400gm 100% Free L-Amino Acids 1/3 Of Fat Blend As Medium Chain Triglycerides (Mct) To Aid Fat Absorption With Lcp* To Support Healthy Brain And Eye Development Hypoallergenic Supports Normal Growth And Improves Iron Status Pbs Listed (Authority Required. See Pbs Schedule For Full Criteria) *Long Chain Polyunsaturated Fatty Acids In The Form Of Docosahexaenoic Acid (Dha) And Arachidonic Acid (Ara). ...
TREK‐1 is a member of the 2P domain family of K+ channels (Fink et al., 1996; Patel et al., 1999, 2001; Lesage and Lazdunski, 2000; Patel and Honoré, 2001a,b). The biophysical and pharmacological properties of TREK‐1 are similar to those described for the serotonin‐sensitive K+ channel (S channel), which underlies presynaptic sensitization, a simple form of learning, in Aplysia (Belardetti and Siegelbaum, 1988; Hawkins et al., 1993).. A variety of chemical factors stimulate TREK‐1 activity. These include diverse cellular lipids such as long chain polyunsaturated fatty acids and lysophospholipids (Patel et al., 1998; Maingret et al., 2000b). In particular, TREK‐1 is opened by arachidonic acid (AA) (Fink et al., 1996; Patel et al., 1998; Maingret et al., 2000b). Since this activation occurs in excised patches, the effect of AA is believed to be either direct or via an interaction with the membrane bilayer (Patel et al., 1998, 2001; Maingret et al., 2000b). Inhalational anaesthetics ...
7000 infants registered in the Swedish ROP registry is being developed. Based on birth characteristics only, it appears to predict total risk of ROP-treatment as well as models including weight measurements. Treatment risk peaked at 12 weeks of age. Laser therapy is the method of choice for severe ROP. Anti-VEGF therapies are implemented worldwide despite insufficient knowledge of choice of drug, dosage and long term systemic effects. Prevention of ROP may be achieved through oxygen control and provision of the mothers breastmilk. Other interventions such as supplementation with long chain polyunsaturated fatty acids and preservation of fetal haemoglobin are investigated. ...
Pathway:Rat:Unsaturated Fatty Acid Beta Oxidation BiGCaT]] moved to [[Pathway:Rattus norvegicus:Unsaturated Fatty Acid Beta Oxidation BiGCaT]]: Renaming ...
Polyunsaturated fatty acids are one of the nutritional factors that have been reported to have various biological roles as well as beneficial effects on health. Dyslipidemia is an important risk factor in the pathogenesis of DR and diabetic macular edema.2,17 Polyunsaturated fatty acids have a suppressive effect on lipogenesis in the liver by repressing the sterol regulatory element-binding protein (SREBP)-1.18 Besides, PUFAs are one of the ligands responsible for the activation of peroxisome proliferator-activated receptor α (PPAR-α),19 a nuclear receptor protein that has inhibitory effects on the vascular endothelial growth factor (VEGF) pathway. Implicated in angiogenesis, inflammation, and cell migration,20 VEGF should have a role in the development and progression of DR.21 For that reason, PPAR-α agonist is expected to have an inhibitory effect on DR. For example, fenofibrate, a lipid-lowering drug also known as a PPAR-α agonist, has reduced the need for laser treatment for DR in ...
The Eicosanoid Core Laboratory is a Vanderbilt University Shared Resource designated for the analysis of oxidation products of arachidonic acid and other polyunsaturated fatty acids. These molecules include isoprostanes, prostaglandins, leukotrienes, epoxyeicosatetraenoic acids (EETs), and hydroxy- and di-hydroxy-eicosatetraenoic acids (20-HETE and DHETs), and their metabolites. The services available in the Core are listed in the Table below. All of the assays performed are validated highly precise, accurate, and sensitive mass spectrometric assays, many of which were developed by Core personnel.
Walk into any health food shop and you might think that omega-3 highly unsaturated fatty acids are a cure for all ills. The hype for these dietary supplements arose from research that appeared to find various benefits, including many trials that reported beneficial effects in depressive disorders. However, other trials have reported essentially no effect. In this podcast Dr Brian Hallahan discusses the key findings of his meta-analysis, which pools together all the data accumulated on the subject in an attempt to cut through to the truth about omega-3s and depression. ...
Prostaglandins - biologically active substances produced in cells from arachidonic and some other unsaturated fatty acids (thomayerova) contained in the phospholipids of membranes. Depending on the pathways of enzymatic biotransformation arachidonic acid can be formed not only GHG (including prostacyclin and thromboxane of the corresponding synthase), and leukotrienes (products of oxidation of 5-lipooksigenaznomu mechanism).. The peculiarities of the chemical structure of PG is divided into groups, with Latin indices A, b, E, F, etc., and subgroup, denoted by Arabic numerals (PGE1, PGE2, etc.), according to the number of double bonds in the molecule ...
Introduction - Long Chain Polysaturated fats The aim of this assignment is to provide a recommendation on the supplementation of infant...
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Effect of docosapentaenoic acid (DPA) on arachidonic acid (AA) stimulated production of MMP-9. MonoMac 6 cells (0.8 × 106 cells/ml in X-Vivo 15) were incubated
Biosynthesis in vertebrates of long-chain polyunsaturated fatty acids (LC-PUFA) such as arachidonic (ARA; 20:4n-6), eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids requires the catalysis by fatty acyl desaturases (Fads). A vertebrate Fad with Δ4 activity catalyzing the direct conversion of 22:5n-3 to DHA was discovered in the marine teleost rabbitfish Siganus canaliculatus. Recent studies in vertebrates have shown that miRNAs may participate in the regulation of lipid metabolism at post-transcription level. However, their roles in LC-PUFA biosynthesis were not known. In the present study, in silico analysis predicts that the rabbitfish Δ4 Fad may be a target of miR-17 and thus we cloned miR-17, which is located at the forepart of the miR-17-92 cluster. Dual luciferase reporter assays demonstrated that miR-17 targeted the 3UTR of Δ4 Fad directly. Furthermore, the expression level of miR-17 displayed an inverse pattern with that of Δ4 Fad mRNA in gill, liver and eyes, ...
Mutants of Arabidopsis that contain reduced levels of polyunsaturated fatty acids showed growth characteristics at 22 degrees C that were very similar to wild type. By contrast, at 12 degrees C, the mutants failed to undergo stem elongation during reproductive growth although they produced normal flowers and fertile seeds. After transfer to 6 degrees C, rosette leaves of the mutants gradually died, and the plants were inviable. These different responses of the mutant plants at 12 degrees C and 6 degrees C suggest that distinct functions may be affected at these two temperatures. The gradual development of symptoms at 6 degrees C and other lines of evidence argue against a general collapse of membrane integrity as the cause of the lethal phenotype. Rather, they indicate that the decrease in polyunsaturated membrane lipids may initially have relatively limited effects in disrupting cellular function.. ...
In addition to modifying the diet, the intake of polyunsaturated fatty acids may be increased by taking supplements. Some of these supplements actually have
This meta-analysis suggests that dietary and non-dietary intake of n-3 polyunsaturated fatty acids reduces overall mortality, mortality due to myocardial infarction, and sudden death in patients with coronary heart disease.
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.