Cancer-related fatigue (CRF) is one of the most common symptoms experienced by cancer patients (CPs). The Brief Fatigue Inventory (BFI) is a reliable instrument to assess CRF in CPs. The aim of this s
Protracted treatment on intensive care unit (ICU) sets the patients at increased risk for the development of chronic critical illness (CCI). Muscular and cardio-respiratory deconditioning are common long-term sequelae, going along with a state of chronic fatigue. At present, findings regarding the frequency, long-term course, and associated factors of self-reported fatigue following ICU treatment of CCI patients are lacking. CCI patients with the diagnosis of critical illness polyneuropathy/myopathy (CIP/CIM) were assessed at three time points. Four weeks following the discharge from ICU at acute care hospital (t1), eligibility for study participation was asserted. Self-reported fatigue was measured using the Multidimensional Fatigue Inventory (MFI-20) via telephone contact at 3 (t2, n = 113) and 6 months (t3, n = 91) following discharge from ICU at acute care hospital. At both 3 and 6 months, nearly every second CCI patient showed clinically relevant fatigue symptoms (t2/t3: n = 53/n = 51, point
Cancer-related fatigue is a subjective symptom of fatigue that is experienced by nearly all cancer patients. Among patients receiving cancer treatment other than surgery, it is essentially universal. Fatigue is a normal and expected side effect of most forms of chemotherapy, radiation therapy, and biotherapy. On average, cancer-related fatigue is "more severe, more distressing, and less likely to be relieved by rest" than fatigue experienced by healthy people. It can range from mild to severe, and may be either temporary or a long-term effect. Fatigue may be a symptom of the cancer, or it may be the result of treatments for the cancer. The National Comprehensive Cancer Network defines cancer-related fatigue as "a distressing persistent, subjective sense of physical, emotional and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning". Cancer-related fatigue is a chronic fatigue (persistent ...
Background and objectives: To explore if intravenous iron isomaltoside (Monofer ®) leads to a better relief of fatigue than current treatment practice with oral iron in women suffering from severe fatigue after postpartum hemorrhage. Materials and methods: This is a subanalysis of a single-center, open-label, randomized controlled trial conducted in women suffering from postpartum hemorrhage. Participants were randomized 1:1 to 1200 mg iron isomaltoside or current treatment practice with oral iron. We measured fatigue by the Multidimensional Fatigue Inventory (MFI) and Edinburgh Postnatal Depression Scale, and determined hematological parameters. The subanalysis includes all participants with a high fatigue score (MFI physical fatigue score ,15) at inclusion. The primary endpoint was aggregated change in physical fatigue score from inclusion to 12 weeks postpartum with a predefined minimum clinically relevant difference of 1.8. The trial is registered at ClinicalTrials.gov (identifier: ...
Fatigue is a common problem among individuals with Parkinsons disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD. Here we determined the dimensionality of the constructs of fatigue. Four recommended scales, the Fatigue Severity Scale, Functional Assessment of Chronic Illness Therapy-Fatigue, Parkinson Fatigue Scale and Visual Analog Fatigue Scale (VAFS) were tested against quality of life measures including cognition, depression, sleep, life orientation, physical activity and PD symptoms in 22 PD subjects and 15 caregivers. Fatigue was associated with many quality of life variables, with the PDQ-39 summary index showing the strongest association. PD subjects agreed more strongly than caregivers that they experienced higher levels of fatigue. 27% of PD subjects rated fatigue as one of their top three most bothersome symptoms. The constructs of fatigue was captured within one dimension which explained 67% of
ASCO Abstract Number: 9004. CHICAGO - Cancer-related fatigue is often a major problem for cancer patients, beginning at diagnosis, during treatment and after completing therapy. Researchers at Mayo Clinic and the North Central Cancer Treatment Group (NCCTG) recently completed a study testing methylphenidate in the treatment of cancer-related fatigue and found that, while it did not improve fatigue for a broad group of patients, the data did not rule out a benefit for those with stage III/IV cancer. Results of this NCCTG study, N05C7, will be presented on Sunday, June 6, 2010, at the American Society of Clinical Oncology annual meeting in Chicago.. VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Deb Barton is available on the Mayo Clinic News Blog.. "Cancer-related fatigue can impact a patients ability to tolerate therapy and their overall quality of life," says Debra Barton, R.N., Ph.D., associate professor of oncology at Mayo Clinic in ...
SIG members first examined the subjective fatigue experience dimension of the Checklist Individual Strength (CIS20-R) [20], a well validated and widely used multidimensional self-report measure that aims to assess subjective experience of fatigue, concentration, motivation, and physical activity. Some SIG members expressed the view that the 8 items of the fatigue subscale seemed to evaluate peripheral or muscle fatigue consecutive to physical activity rather than central fatigue per se. Others were of the opinion that the subjective fatigue items appeared to have been devised for healthy people rather than for individuals with chronic neuromuscular conditions. In addition, SIG members expressed some concerns regarding the content validity of the fatigue subscale, most items seemingly focusing on physical fatigue and not sufficiently documenting aspects of mental fatigue or weariness that many patients typically feel upon morning awakening. Moreover, many items are not plausible for DM1. For ...
When sarcoidosis is in clinical remission, complaints of chronic fatigue often persist. The exact features of this post-inflammatory fatigue are unknown. This study assesses the severity of fatigue and the presence of fatigue-related symptoms in sarcoidosis-in-clinical-remission. Furthermore, we evaluate psychological distress, pain and patient-reported sleep quality, and record physical activity levels and muscle strength as objective assessments of fatigue. Lastly, we assess the severity of fatigue at a follow-up.. Methods: Seventy-five patients with sarcoidosis-in-clinical-remission were evaluated with the Checklist Individual Strength (fatigue), the SymptomChecklist-90 (psychological distress), the McGill Pain Questionnaire (pain), standardized interview (fatigue-related symptoms), sleep diary, accelerometer and muscle strength tests.. Results: Fatigue severity mean score in sarcoidosis patients in-clinical-remission was high (fatigue-severity score: 30.5±15.5), and fatigue-related symptoms ...
Cancer-related fatigue is a symptom with great implications for the quality of life of those that experience it. It is regarded as one of the most distressing symptoms that people with cancer develop. Its aetiology is complex, and although the mechanisms underlying fatigue have not been fully clarified it is evident that it is exacerbated by treatments intended to cure or palliate the disease. Patients at risk of cancer-related fatigue need access to information that will enable them to manage it effectively. There are a growing number of materials available to patients in different European countries on this topic, but it is unclear how useful patients find these. This study was undertaken to explore this through conducting focus groups with patients in the United Kingdom and Switzerland. One focus group was conducted in each country. Findings from these determined that individuals voiced common concerns: fatigue had not been addressed in the clinical setting - individuals surmised why this ...
Brief Fatigue Inventory (BFI) consist of 3 items that assess the severity of fatigue and 6 items that assess the impact of fatigue on daily functioning in a 10-points scale with 0 as no fatigue or does not interfere with daily functioning and 10 as bad fatigue or completely interferes. The scores for the six items were summed up to form a total interference score. The linear analogue scale of fatigue was a 10-points scale with 0 as no fatigue and 10 as bad fatigue. All scores were then transformed into 0 to 100 scale, with 100 as less fatigue/less interference. Change from baseline to week 4 was calculated by subtracting the baseline scores from the scores at week 4 ...
Change between Day 7 to Baseline in FACIT-F (Functional Assessment of Chronic illness Therapy-Fatigue) & FACT-G (Functional Assessment of Cancer Therapy-General) scores. Participants rate quality of life using FACT-G consisting of 33 questions with 5 domains assessing physical and social, emotional & functional well being & relationship with physician, remaining 5 assess extent to which each domain affects overall quality of life on 5-point scale from 0 (not at all) to 4 (very much); total score obtained by summing individual subscale scores (0-132). FACIT-F consists of 13 items where participants rate intensity of fatigue & its related symptoms on a scale of 0-4 from 0 not at all to 4 very much. The responses to FACIT fatigue questionnaire are each measured on 4‐point Likert scale with total score ranges from 0 to 52. High scores represent less fatigue. Reported is the mean change of the summed value of all reported scores for the FACT-G or the FACIT-F from baseline to Day 7 ...
Chronic fatigue related to cancer is a common syndrome during and following cancer treatment that manifests as a constant lack of energy that is not brought on by exertion, nor relieved by sleep. While cancer-related fatigue is not a well understood problem that can be associated with any single cause, consensus by health authorities is that it is a multifactorial problem involving the bodys reaction to both chemotherapy and radiation therapy; anemia resulting from decreased red blood cells that leaves tissues oxygen starved; and/or a decrease of vital nutrients.. One proposed source of a centuries-old treatment for people suffering from fatigue similar to that experienced by cancer patients is the use of adaptogens. Adaptogens are a class of herbal remedies noted for their potency as stress fighters capable of either bringing an overly stressed body back to its normal healthy state or in coping with stressors such as physical exertion, toxins, lack of sleep and psychological distress.. One of ...
The overall purpose was to explore the experience of living with chronic heart failure among patients in primary healthcare. Comparisons were made between patients with confirmed heart failure (HF, n=49), patients with symptoms indicating HF but with no HF (NHF, n=59), and a reference group (n=40). The mean age was 77 years. Patients in the HF and NHF groups had more general and physical fatigue, more reduced activity, worse physical quality of life and higher degree of depression compared with the reference group. The HF group had also higher degree of physical fatigue and worse physical quality of life than the NHF group. When comparing degrees of depression between the three groups and adjusting for fatigue, the physical dimension of fatigue was of greater importance in explaining group differences. In the HF group general fatigue was more closely related to limitations in role functioning for physical reasons than to reduced physical function per se. Women experienced more fatigue than men. ...
There is no way to know whether you will have fatigue or how bad it will be. But there are things you can do to help fight fatigue. Here are 7 tips to help manage cancer-related fatigue.
The etiology of severe fatigue in T1DM is not well understood. It seems obvious that physiological diabetes-related factors such as haemoglobin A1c (HbA1c) levels or variations in blood glucose levels are associated with fatigue. While fatigue is a classical presenting symptom of hyperglycaemia, in our cross-sectional study no relationship between glucose control (HbA1c levels) and fatigue severity was found [3]. Also, parameters gathered during continuous glucose monitoring such as the blood glucose variability were unrelated to persistent fatigue. Other diabetes-related factors were correlated to fatigue: the number of complications due to diabetes, diabetes-related distress and diabetes specific self-efficacy. Also, there was a univariate relationship between fatigue and somatic comorbidity. In a multiple regression, several cognitive behavioural factors were found to be potential determinants of fatigue: disrupted sleep-wake patterns, low physical activity, catastrophising thoughts about ...
OBJECTIVE: Cancer-related fatigue (CRF) is one of the most common unrelieved symptoms experienced by patients. CRF is underrecognized and undertreated due to a lack of clinically sensitive instruments that integrate easily into clinics. Modern computerized adaptive testing (CAT) can overcome these obstacles by enabling precise assessment of fatigue without requiring the administration of a large number of questions. A working item bank is essential for development of a CAT platform. The present report describes the building of an operational item bank for use in clinical settings with the ultimate goal of improving CRF identification and treatment. STUDY DESIGN AND SETTING: The sample included 301 cancer patients. Psychometric properties of items were examined by using Rasch analysis, an Item Response Theory (IRT) model. RESULTS AND CONCLUSION: The final bank includes 72 items. These 72 unidimensional items explained 57.5% of the variance, based on factor analysis results. Excellent internal ...
Results Sjögrens patients had higher scores on all five fatigue dimensions (p,0.001) and lower scores on moderate and vigorous intensity activity (p≤0.001) compared with control participants. In the Sjögrens group, lower physical activity and higher activity avoidance and somatic focus were associated with more severe fatigue on most fatigue dimensions. For general fatigue and physical fatigue, especially the combination of low physical activity and high activity avoidance was associated with more severe fatigue (p,0.05).. ...
Fatigue in patients with cancers of the breast or prostate undergoing radical radiotherapy. To determine the prevalence, severity, and correlates of fatigue among patients with cancers of the Prostate or breast receiving high dose radiotherapy with curative intent, a prospective, questionnaire based study, evaluated a convenience sample of 62 patients who were about to start a course of radiotherapy. Patients were assessed immediately prior to treatment, and again within a week of finishing. Fatigue was assessed using the Fatigue Severity Scale (FSS) and the Bidimensional Fatigue Scale (BFS). Quality of life was assessed using the European Organisation for Research and Treatment of Cancer 30-item Quality of Life Questionnaire (EORTC QLQc30). Psychological distress was assessed using the Hospital Anxiety and Depression Scale (HADS). Personality Traits were assessed using the Eysenck Personality Inventory (EPI). Fatigue severity increased significantly on 3 out of the 5 assessment instruments ...
The objective of this study was to examine whether multiple sclerosis (MS)-related fatigue affects patients cognitive performance. Thirty patients who had substantial fatigue in conjunction with MS and who reported marked diurnal variability in the severity of their fatigue were tested on two occasions: during a period of high fatigue and during a period of relatively low fatigue. The order of these sessions was counterbalanced across patients. During both sessions, patients completed a questionnaire concerning their present state of fatigue and a battery of neuropsychological tests of planning, selective attention, and paired associate learning. Although patients confirmed greater fatigue during the period of high fatigue and felt they had performed more poorly during this period, there were no differences in cognitive performance that could be attributed to fatigue. Instead, all subjects showed improvement from the first to the second session regardless of whether the latter entailed a period ...
Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system is activated, heat shock proteins (HSPs) are produced to protect cells. Some extracellular HSPs appear to recognize cellular targets in the brain, and we hypothesize that fatigue may be generated by specific HSPs signalling through neuronal or glial cells in the central nervous system. From a cohort of patients with primary Sjögrens syndrome, 20 patients with high and 20 patients with low fatigue were selected. Fatigue was evaluated with a fatigue visual analogue scale. Plasma concentrations of HSP32, HSP60, HSP72 and HSP90α were measured and analysed to determine if there were associations with the level of fatigue. Plasma concentrations of HSP90α were significantly higher in patients with high fatigue compared with those with low fatigue, and there was a tendency to ...
Exercise and/or psychological interventions are more effective strategies than pharmaceutical interventions to reduce cancer-related fatigue.
Stone, P, Ream, E, Richardson, A, Thomas, H, Andrews, P, Campbell, P, Dawson, T, Edwards, J, Goldie, T, Hammick, M et al, Kearney, N, Lean, M, Rapley, D, Smith, AG, Teague, C and Young, A. (2003) Cancer-related fatigue - a difference of opinion? Results of a multicentre survey of healthcare professionals, patients and caregivers ...
The objective of this study is to develop a structured and evidence-based self-management program to cope with cancer-related fatigue and to assess the
Horneber, M; Fischer, I; Dimeo, F; Rüffer, J U; Weis, J Cancer-Related Fatigue: Epidemiology, Pathogenesis, Diagnosis, and Treatment Dtsch Arztebl Int 2012; 109(9): ; DOI: /arztebl
OBJECTIVE: To examine patient-reported outcomes (PROs) in patients with different rheumatoid arthritis (RA) disease activity levels and identify residual symptoms. METHODS: Post hoc analyses of overall and Japanese data from two randomized controlled trials including RA patients with previous inadequate responses to methotrexate (NCT01710358) or no/minimal previous disease-modifying antirheumatic drug treatment (NCT01711359) (sponsor: Eli Lilly and Company). Week 24 assessments were disease activity (Simplified Disease Activity Index, Disease Activity Score/Disease Activity Score 28 joints-erythrocyte sedimentation rate) and PROs (pain visual analog scale [VAS], morning joint stiffness [MJS], Health Assessment Questionnaire-Disability Index, Functional Assessment of Chronic Illness Therapy-Fatigue, and Medical Outcomes Study Short Form 36 Health Survey Physical and Mental Component Scores ...
Objective. Sleep disturbance and chronic fatigue are common in rheumatoid arthritis (RA) and contribute to disability, symptomatology, and healthcare use. It has long been recognized in other populations that exercise can improve sleep and diminish fatigue. The effect of exercise on sleep quality and fatigue in RA has not been evaluated. Methods. Ours is a randomized controlled study in RA to determine the effect of an exercise program on sleep quality and fatigue. These were measured using the Pittsburgh Sleep Quality Index and the Fatigue Severity Scale. Patients were randomized to either a 12-week, home-based exercise intervention or usual care. The exercise program consisted of specific exercises to target individual deficiencies identified using the Health Assessment Questionnaire (HAQ) with cardiovascular work as per the guidelines. The intervention group was evaluated on a 3-week basis. Full evaluation was carried out at baseline and at 12 weeks. Results. Forty patients were randomized to ...
Context: High quality fatigue rating scales are needed to advance understanding of fatigue nd determine the efficacy of interventions. Several fatigue scales are used in Parkinsons isease, but few have been tested using modern psychometric methodology (Rasch analysis).. Objectives: To examine the measuring properties of the generic Functional Assessment of hronic Illness Therapy - Fatigue (FACIT-F) scale and the condition-specific 16-item arkinson Fatigue Scale (PFS-16) using Rasch analysis.. Methods: Postal survey data (n=150; 47% women; mean age, 70) were Rasch analyzed. FS-16 scores were tested according both to the original polytomous and the suggested lternative dichotomized scoring methods.. Results: The PFS-16 showed overall Rasch model fit whereas the FACIT-F showed signs of isfit, which probably was due to a sleepiness-related item and mixing of ositively/negatively worded items. There was no differential tem functioning by disease uration but by fatigue status (greater likelihood of ...
Fatigue detection software is intended to reduce fatigue related fatalities and incidents. Several companies are working on a technology for use in industries such as mining, road- and rail haulage and aviation. The technology may soon find wider applications in industries such as health care and education. In an operational environment scenario where operating systems are dependent on human performance, fatigue can be defined as an inclination to degrade performance. Thus, fatigue is an indicator of baseline risk for the occurrence of errors and accidents. Globally mining operations are at risk of fatigued workers. Sleepiness and fatigue increase human error and contribute to accidents which can be fatal. Factors compounding fatigue levels in mine workers include; disruptions in circadian rhythms due to shift work, exposure to noise, vibration and chemicals, monotonous and repetitive nature of tasks and night shift driving. Studies recognise a connotation between lifestyle and fatigue. Mine ...
Background. Fatigue is a frequently reported symptom in women following early breast cancer treatment and may be increased with adjuvant breast radiotherapy (RT). Within the START Quality of Life (QoL) sub study the effect of a range of clinical and psychological factors and symptoms on fatigue is investigated in women following RT for early stage breast cancer.. Method. A subgroup of women were recruited to the QoL study and completed the EORTC QLQ C-30, BR23 and HADS at baseline (after surgery +/- chemotherapy (CT) but before RT) and at 6, 12, 24 and 60 months. Fatigue was measured as a symptom subscale comprised of 3 individual items. The effect of age, time from surgery, type of surgery, CT, endocrine therapy, RT schedule and change over time were tested using a GEE model. Correlations between fatigue and anxiety, depression, insomnia and physical functioning were examined.. Results. 2180 (99%) women completed baseline QoL. Fatigue levels were highest pre RT (median 33.33) and decreased ...
PURPOSE: Fatigue is a symptom in patients with chronic gastrointestinal (GI) and liver diseases. Different instruments have been developed to assess the severity of fatigue and the 40-item Fatigue Impact Scale (FIS) is among the most widely used. Shorter versions of FIS include the 21-item Modified Fatigue Impact Scale (MFIS), and an eight-item version for everyday use. The study aimed to assess construct validity, reliability, and sufficiency of the raw score of the original FIS with 40 items, and examine the sufficiency of the 21 items from the Modified scale and the eight items of the Daily Fatigue Impact Scale (D-FIS), all of which are embedded in the 40-item scale ...
Introduction: Fatigue is the most troublesome untreated symptom during radical breast radiotherapy. This situation persists due to an uncertain aetiology and an inability to identify patients at high risk of experiencing significant fatigue during subsequent radiotherapy. Aetiological investigations of the current study concentrated on discriminating the radiotherapy-specific effects on fatigue, in a context encompassing multiple psychological and physiological covariates. Prognostic aspects sought to characterise a high-risk patient. Methods: The study cohort comprised 100 women, diagnosed with Stage 0 to IIA breast cancer, and prescribed standard whole breast irradiation to 40Gy in 15 fractions over three weeks. The use of systemic therapies was an exclusion criterion. A cytokine-induced sickness behaviour model framed the study investigations, and provided a theoretical link between localised radiotherapy and systemic fatigue. The outcome fatigue was assessed before, during and four weeks ...
The Fatigue Severity Score (FSS), the Fatigue Impact Scale (FIS), and the ModifiedFatigue Impact Scale (MFIS) are the most commonly used scales for fatigue assess-ment in MS patients.The FSS is composed of 9 items that assess perceivedSubjects are asked to assign a number from 1 (strongly disagree) to 7(strongly agree) stating their agreement with each statement.Responses aresummed and averaged, with a score of 4 or more indicating significant The FIS has been identified by the Multiple Sclerosis Council for Clinical Practice Guidelines as the most appropriate for assessing the impact of MS-related fatigueon quality of life.The FIS is a retrospective tool designed to evaluate fatigue duringthe past month. The FIS has separate subscales for physical, psychosocial, andcognitive functions, which span more than 40 statements.Subjects are asked toscore the effect of fatigue on those 4 dimensions using a 5-point scale from 0 (noproblem) to 4 (extreme problem). Since the FIS takes approximately 10 to ...
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Overcoming Barriers. Fatigue. Fatigue is common in MS, exercise and fatigue management education strategies will actually help your fatigue level in the long term(8).. Heat Sensitivity and MS. Physical and sensory symptoms may temporarily increase with small increases in environmental or body temperature. People with MS should be encouraged to keep cool and well hydrated during exercise sessions, for example using cool clothing and try to exercise inside or in the shade.. Research is continuing to address what exercise and strategies are best for fatigue and heat sensitivity; for now it is recommended to follow the Physical activity guidelines, remember to build up to these guidelines slowly. Stretching exercises are important too, and continuing these when fatigue levels, or temperatures, are high is still important.. Finding support. Support to help you exercise is not to be underestimated. Research indicates that learning about exercise, working with other to overcome your barriers and ...
METHODS: This randomized controlled clinical trial was carried out in a multiple sclerosis clinic in Iran, where 37 outpatient women with MS were randomized into an exercise group (N.=18) and a control group (N.=19). In the exercise group, aquatic exercise was performed for 45 minutes, 3 times per week for 8 weeks. The control group did not receive any interventions (aquatic exercise) and were asked to maintain their normal treatments. The severity and perception of fatigue and quality of life (QoL) were measured using the Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS), and Multicultural Quality of Life Index (MQLIM) questionnaires ...
TY - JOUR. T1 - Is fatigue a disease-specific or generic symptom in chronic medical conditions?. AU - Menting, Juliane. AU - Tack, Cees J. AU - Bleijenberg, Gijs. AU - Donders, Rogier. AU - Droogleever Fortuyn, Hal A. AU - Fransen, Jaap. AU - Goedendorp, Martine M. AU - Kalkman, Joke S. AU - Strik-Albers, Riet. AU - van Alfen, Nens. AU - van der Werf, Sieberen P. AU - Voermans, Nicol C. AU - van Engelen, Baziel G. AU - Knoop, Hans. N1 - (c) 2018 APA, all rights reserved).. PY - 2018/6. Y1 - 2018/6. N2 - OBJECTIVE: Severe fatigue is highly prevalent in various chronic diseases. Disease-specific fatigue models have been developed, but it is possible that fatigue-related factors in these models are similar across diseases. The purpose of the current study was to determine the amount of variance in fatigue severity explained by: (a) the specific disease, (b) factors associated with fatigue across different chronic diseases (transdiagnostic factors), and (c) the interactions between these factors and ...
BSAP: Bone-Specific Alkaline Phosphatase; FACIT-Fatigue: Functional Assessment of Chronic Illness Therapy-Fatigue; HRQOL: health-Related Quality of Life; IGFBP: Insulin-like Growth Factor Binding Protein; IL: Interleukin; IGF: Insulin-like Growth Factor; MASQ: Multiple Abilities Self-Report Questionnaire; NTx: N-Telopeptides of Type I Collagen; IES-R: Impact of Event Scale-Revised; POMS-SF: Profile of Mood States-Short Form; RSE: Rosenberg Self-Esteem Scale; bold text with*: statistically significant ...
The cyclic material behavior is investigated, by strain-controlled testing, of 8 mm thick sheet metal specimens and butt joints, manufactured by manual gas metal arc welding (GMAW). The materials used in this investigation are the high-strength structural steels S960QL, S960M and S1100QL. Trilinear strain-life curves and cyclic stress-strain curves have been derived for the base material and the as-welded state of each steel grade. Due to the cyclic softening in combination with a high load level at the initial load cycle, the cyclic stress-strain curve cannot be applied directly for a fatigue assessment of welded structures. Therefore, the transient effects have been analyzed in order to describe the time-variant material behavior in a more detailed manner. This should be the basis for the enhancement of the fatigue life estimation ...
Methods In a two center subgroup analysis from the ADAPTHERA cohort, we studied quality of life indexes such as Hannover Functional Ability Questionnaire (HFAQ), Health Assessment Questionnaire (HAQ), EuroQol-5D-3L (EQ-5D-3L), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) and World Health Organisation-5 Well Being Index (WHO-5) in patients with VERA. Moreover, we examined the statistical relationship of these indexes with various clinical and laboratory RA associated parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF)-/ cyclic citrullinated peptide antibodies (anti-CCP)-status and Disease Activity Score 28 (DAS28) as well as its components [counts of tender and swollen joints, Visual Analogue Scale (VAS)]. ...
This study, the first of its kind in chronic stroke, has demonstrated that self-reported post-stroke fatigue is significantly reduced after 6 weeks of modafinil therapy compared with placebo. In addition to the reduction in fatigue, it was observed that there was a significant improvement in participants quality of life. The secondary fatigue measure, the FSS, also showed a significant reduction in participants self-reported fatigue, confirming the primary end point. However, no significant change was reported for mood or cognition with modafinil therapy. These positive findings are encouraging, but preliminary, owing to the small size of the study.. The reported significant improvement in patient quality of life was due mainly to improvement in the subdomains of energy, mobility, social roles, vision, and thinking, which are critically important aspects of post-stroke life. Although there was no statistically significant improvement in the subdomains of family, language, mood, personality, ...
Abstract: Purpose/Objectives: To test whether sleep disturbance mediates the effect of pain on fatigue. Design: Cross-sectional Setting: Radiation therapy clinic, oncology ambulatory clinic, and inpatient oncology unit in an urban teaching hospital. Sample: 84 patients with cancer with multiple primary diagnoses who were experiencing pain. Fifty-three percent were female and 92% were Caucasian, with a mean age of 54 years. Methods: All participants completed a symptom questionnaire that included the brief pain inventory - short form, the Pittsburgh Sleep Quality Index, and the fatigue subscale of the Profile of Mood States questionnaire. Multistage linear regression was used to test a mediation model. Main Research Variables: Fatigue, pain, and sleep disturbance. Findings: Mediation analyses indicate that pain influences fatigue directly as well as indirectly by its effect on sleep. About 20% (adjusted R2 = 0.20) of the variation in fatigue is explained by pain. Thirty-five percent of the ...
Aim: The aim of this study was to investigate balance problems and affecting factors in stable chronic obstructive pulmonary disease (COPD) patients.. Methods: Patients who were hospitalized in the department of chest disease with a diagnosis of COPD with stable clinical condition participated in this study. Functional balance of patients was assessed by Berg Balance Scale (BBS). Tampa Scale for Kinesiophobia (TSK) was used to inquire fear of effort adapted symptom of dyspnea. Fatique was examined by Checklist Individual Strength (CIS) Scale. Severity of dyspnea was evaluated using Medical Research Council Scale (MRCS).. Results: A total of 30 patients, 4 women and 26 men were enrolled (mean age= 62.0 ± 10.4 years, mean body mass index= 24.09 ± 4.2 kg/m2). Mean FEV1% predicted was 29.46 ± 14.75. Cases was found with a moderate risk of falling (mean BBS score= 34.16 ± 15:58). The fear of effort due to dyspnea was found to be high (mean TSK score= 42.0 ± 14.6). There was no relationship ...
TY - JOUR. T1 - Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. AU - Schwartz, A. L.. AU - Mori, M.. AU - Gao, R.. AU - Nail, L. M.. AU - King, M. E.. PY - 2001. Y1 - 2001. N2 - SCHWARTZ, A. L., M. MORI, R. GAO, L. M. NAIL, and M. E. KING. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med. Sci. Sports Exerc., Vol. 33, No. 5, 2001, pp. 000-000. Purpose: Cancer treatment-related fatigue is the most prevalent and distressing symptom of cancer therapy. Interventions to minimize fatigue are needed. The purpose of this study was to examine the relationship between exercise and fatigue over the first three cycles of chemotherapy in women receiving either cyclophosphamide, methotrexate, and fluorouracil (CMF) or doxorubicin and cyclophosphamide (AC) for breast cancer. Methods: Seventy-two newly diagnosed women with breast cancer were instructed in a home-based moderate-intensity exercise intervention. Measures of functional ability, ...
This study demonstrated that fatigue levels are high in patients with SSc compared with the general population, which is consistent with the results of a recent systematic review that found that fatigue related to SSc was significantly higher than in general population samples and similar to patients with other rheumatic diseases or patients with cancer in active treatment (10). In multivariate analysis, statistically significant correlates of fatigue included number of medical comorbidities, patient-reported breathing problems, patient-reported number of GI symptoms, and smoking. Tender joint count also approached statistical significance. Physician-rated global disease severity was a robust predictor of fatigue on a bivariate basis and after controlling for sociodemographic factors, but was no longer statistically significant when medical comorbidities and specific disease factors were included in the model. Depressive symptoms and pain were robust predictors of fatigue, but sociodemographic ...
In this study, re-activation of salivary HHV-6 was observed in 9 of 17 subjects before the supplement intake, and the salivary HHV-6 was decreased to less than the detection limit after intake of the oyster meat extract powder other than 1 subject. The results and discussion described above indicate that the intake of oyster meat extract powder probably reduced the objective fatigue levels and subjective fatigue feeling in the healthy adults who accumulate usual fatigue through the inhibition of re-activation of viruses by controlling the generation of cytokines. Chronic fatigue syndrome (CFS) is a disease by which strong fatigue is felt for a half year or longer without any obvious reasons, and the cause of CFS has been unknown even now. The decrease of the homeostasis of immune system induced by various kinds of environmental factors (physical and psychological stress) and genetic factors is proposed for the mechanism of onset of CFS as a hypothesis [22]. Chalders fatigue scale and the ...
BACKGROUND: Fatigue is associated with cancer and its treatment but we know little about how many and which patients suffer fatigue of clinical severity. We aimed to determine the prevalence of clinically relevant fatigue (CRF) and its associations in outpatients with various cancer diagnoses. PATIENTS AND METHODS: A survey of outpatients with colorectal, breast, gynaecological, genitourinary, sarcoma, melanoma and miscellaneous tumours at a regional cancer centre. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) fatigue subscale and the Hospital Anxiety and Depression Scale (HADS). These self-report data were linked to demographic and clinical variables. Data were available on 2867 outpatients. RESULTS: The prevalence of CRF (EORTC fatigue subscale | or =40) was 32% (95% confidence interval 31-34%). The variables independently associated with CRF were primary cancer site, having disease present, type of cancer treatment and emotional distress (total HADS score |
Lowry Drug Anti Fatigue Caps 90 Capsules [H160252] - Reduce ammonia & reduce fatigue Scavenge excess ammonia to reduce fatigue. Prolong endurance, even in ultra workouts or races. Increase glycogen availability for energy production. Help prevent cramps. Gluten-Free and Vegan Friendly. Extra Benefits:Although Anti-Fatigue Caps is designed primarily for ammonia reduction in long distance events, the nutrients in the formula are excellent for helping counteract everyday fatigue, even chronic fatigue symptoms. Thoroughly tested over several years in the most extreme athletic endurance events, Anti-Fatigue Caps helps remove fatigue-causing, performance-robbing ammonia. During extended endurance exercise the body accumulates excess ammonia from protein metabolism, which interferes with glycogen production, disrupting energy output. Anti-Fatigue Caps is a one-of-a-kind supplement combining two well-known ammonia-scavenging nutrients. Clean up the waste products of combustion, or youll pay the price. To stay
The effects of surface active additives on rolling-element fatigue life were investigated with the five-ball fatigue tester at conditions where classical subsurface initiated rolling-element fatigue is the sole mode of failure. Test balls of AISI 52100, AISI M-50, and AISI 1018 were run with an acid-treated white oil containing either 2.5 percent sulfurized terpene, 1 percent didodecyl phosphite, or 5 percent chlorinated wax. In general, it was found that the influence of surface active additives was detrimental to rolling-element fatigue life. The chlorinated-wax additive significantly reduced fatigue life by a factor of 7. The base oil with the 2.5 percent sulfurized-terpene additive can reduce fatigue life by as much as 50 percent. No statistical change in fatigue life occurred with the base oil having the 1 percent didodecyl-phosphite additive. The additives used with the base oil did not change the ranking of the bearing steels where rolling-element fatigue life was of subsurface origin.
Staying active is beneficial on many levels including maintaining physical fitness, reaching weight loss goals, reducing fatigue and optimizing cardiovascular health but participating in physical activities should be preceded by practicing senior balance exercises. Please see more information at http://www.exerciseforbalance.com/buy-now Facing fatigue is a common problem among many older individuals. Fatigue can be a result of difficulties with sleeping through the night. Fatigue can be a secondary result of an increased sedentary lifestyle, adopted by many senior citizens. Additionally, fatigue can be caused by cancer and cancer treatments. Whether from the disease itself or the treatment, cancer can be exhausting, but a new review says there are ways to beat back cancer-related fatigue. Recently, Karen Mustian published a study that revealed that exercise can help reduce the fatigue that accompanies cancer and cancer treatments. "Exercise and psychological treatment, and the combination of ...
parallel group phase III trial with an adaptive sample size re-estimation in stroke survivors enrolled 3 or more months after their event. The primary objective is to test the hypothesis that in stroke survivors, 200mg of modafinil taken once daily for at least 56 days significantly improves participant quality of life compared to placebo, due to the improvement of severe and persisting fatigue after stroke. The trial will screen potential participants with the Multidimensional Fatigue Inventory (MFI) score of above 60. Upon consent and if patient meets other specified inclusion and exclusion criteria they will be randomised to either modafinil (200mg) or placebo once daily for 56 days. The main study visits include screening, Day 0, Day 28 and Day 56 for trial assessments with the SF-36, TMTs, FSS, MoCA, DASS 42 and the EQ5D and mRS. Caregivers will also be compete CSI and OCBS at each study visit The study sample size has been calculated to be 300 recruited participants (150 in each arm). ...