Mendoza T, Wang XS, Cleeland CS, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer 85: 1186-1196, 1999.. Mendoza TR, Laudico AV, Wang XS, et al. Assessment of fatigue in cancer patients and community dwellers: validation study of the Filipino version of the Brief Fatigue Inventory. Oncology 79(1-2): 112-117, 2010.. Mystakidou K, Tsilika E, Parpa E, et al. Psychometric properties of the Brief Fatigue Inventory in Greek patients with advanced cancer. J Pain Symptom Manage 36(4): 367-373, 2008.. Lin CC, Chang AP, Chen ML, Cleeland CS, Mendoza TR, Wang XS. Validation of the Taiwanese Version of the Brief Fatigue Inventory. J Pain Symptom Manage 32(1): 52-59, 2006.. Yun YH, Wang XS, Lee JS, et al. Validation study of the Korean version of the Brief Fatigue Inventory. J Pain Symptom Manage 29(2): 165-172, 2005.. Wang XS, Hao XS, Wang Y, et al. Validation study of the Chinese version of the Brief Fatigue Inventory (BFI-C). J Pain Symptom ...
Cancer-related fatigue (CRF) is one of the most common symptoms experienced by cancer patients (CPs). The Brief Fatigue Inventory (BFI) is a reliable instrument to assess CRF in CPs. The aim of this s
Protracted treatment on intensive care unit (ICU) sets the patients at increased risk for the development of chronic critical illness (CCI). Muscular and cardio-respiratory deconditioning are common long-term sequelae, going along with a state of chronic fatigue. At present, findings regarding the frequency, long-term course, and associated factors of self-reported fatigue following ICU treatment of CCI patients are lacking. CCI patients with the diagnosis of critical illness polyneuropathy/myopathy (CIP/CIM) were assessed at three time points. Four weeks following the discharge from ICU at acute care hospital (t1), eligibility for study participation was asserted. Self-reported fatigue was measured using the Multidimensional Fatigue Inventory (MFI-20) via telephone contact at 3 (t2, n = 113) and 6 months (t3, n = 91) following discharge from ICU at acute care hospital. At both 3 and 6 months, nearly every second CCI patient showed clinically relevant fatigue symptoms (t2/t3: n = 53/n = 51, point
Cancer-related fatigue is a subjective symptom of fatigue that is experienced by nearly all cancer patients. Among patients receiving cancer treatment other than surgery, it is essentially universal. Fatigue is a normal and expected side effect of most forms of chemotherapy, radiation therapy, and biotherapy. On average, cancer-related fatigue is more severe, more distressing, and less likely to be relieved by rest than fatigue experienced by healthy people. It can range from mild to severe, and may be either temporary or a long-term effect. Fatigue may be a symptom of the cancer, or it may be the result of treatments for the cancer. The National Comprehensive Cancer Network defines cancer-related fatigue as a distressing persistent, subjective sense of physical, emotional and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning. Cancer-related fatigue is a chronic fatigue (persistent ...
Background and objectives: To explore if intravenous iron isomaltoside (Monofer ®) leads to a better relief of fatigue than current treatment practice with oral iron in women suffering from severe fatigue after postpartum hemorrhage. Materials and methods: This is a subanalysis of a single-center, open-label, randomized controlled trial conducted in women suffering from postpartum hemorrhage. Participants were randomized 1:1 to 1200 mg iron isomaltoside or current treatment practice with oral iron. We measured fatigue by the Multidimensional Fatigue Inventory (MFI) and Edinburgh Postnatal Depression Scale, and determined hematological parameters. The subanalysis includes all participants with a high fatigue score (MFI physical fatigue score ,15) at inclusion. The primary endpoint was aggregated change in physical fatigue score from inclusion to 12 weeks postpartum with a predefined minimum clinically relevant difference of 1.8. The trial is registered at ClinicalTrials.gov (identifier: ...
Fatigue is a common problem among individuals with Parkinsons disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD. Here we determined the dimensionality of the constructs of fatigue. Four recommended scales, the Fatigue Severity Scale, Functional Assessment of Chronic Illness Therapy-Fatigue, Parkinson Fatigue Scale and Visual Analog Fatigue Scale (VAFS) were tested against quality of life measures including cognition, depression, sleep, life orientation, physical activity and PD symptoms in 22 PD subjects and 15 caregivers. Fatigue was associated with many quality of life variables, with the PDQ-39 summary index showing the strongest association. PD subjects agreed more strongly than caregivers that they experienced higher levels of fatigue. 27% of PD subjects rated fatigue as one of their top three most bothersome symptoms. The constructs of fatigue was captured within one dimension which explained 67% of
ASCO Abstract Number: 9004. CHICAGO - Cancer-related fatigue is often a major problem for cancer patients, beginning at diagnosis, during treatment and after completing therapy. Researchers at Mayo Clinic and the North Central Cancer Treatment Group (NCCTG) recently completed a study testing methylphenidate in the treatment of cancer-related fatigue and found that, while it did not improve fatigue for a broad group of patients, the data did not rule out a benefit for those with stage III/IV cancer. Results of this NCCTG study, N05C7, will be presented on Sunday, June 6, 2010, at the American Society of Clinical Oncology annual meeting in Chicago.. VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Deb Barton is available on the Mayo Clinic News Blog.. Cancer-related fatigue can impact a patients ability to tolerate therapy and their overall quality of life, says Debra Barton, R.N., Ph.D., associate professor of oncology at Mayo Clinic in ...
SIG members first examined the subjective fatigue experience dimension of the Checklist Individual Strength (CIS20-R) [20], a well validated and widely used multidimensional self-report measure that aims to assess subjective experience of fatigue, concentration, motivation, and physical activity. Some SIG members expressed the view that the 8 items of the fatigue subscale seemed to evaluate peripheral or muscle fatigue consecutive to physical activity rather than central fatigue per se. Others were of the opinion that the subjective fatigue items appeared to have been devised for healthy people rather than for individuals with chronic neuromuscular conditions. In addition, SIG members expressed some concerns regarding the content validity of the fatigue subscale, most items seemingly focusing on physical fatigue and not sufficiently documenting aspects of mental fatigue or weariness that many patients typically feel upon morning awakening. Moreover, many items are not plausible for DM1. For ...
When sarcoidosis is in clinical remission, complaints of chronic fatigue often persist. The exact features of this post-inflammatory fatigue are unknown. This study assesses the severity of fatigue and the presence of fatigue-related symptoms in sarcoidosis-in-clinical-remission. Furthermore, we evaluate psychological distress, pain and patient-reported sleep quality, and record physical activity levels and muscle strength as objective assessments of fatigue. Lastly, we assess the severity of fatigue at a follow-up.. Methods: Seventy-five patients with sarcoidosis-in-clinical-remission were evaluated with the Checklist Individual Strength (fatigue), the SymptomChecklist-90 (psychological distress), the McGill Pain Questionnaire (pain), standardized interview (fatigue-related symptoms), sleep diary, accelerometer and muscle strength tests.. Results: Fatigue severity mean score in sarcoidosis patients in-clinical-remission was high (fatigue-severity score: 30.5±15.5), and fatigue-related symptoms ...
Cancer-related fatigue is a symptom with great implications for the quality of life of those that experience it. It is regarded as one of the most distressing symptoms that people with cancer develop. Its aetiology is complex, and although the mechanisms underlying fatigue have not been fully clarified it is evident that it is exacerbated by treatments intended to cure or palliate the disease. Patients at risk of cancer-related fatigue need access to information that will enable them to manage it effectively. There are a growing number of materials available to patients in different European countries on this topic, but it is unclear how useful patients find these. This study was undertaken to explore this through conducting focus groups with patients in the United Kingdom and Switzerland. One focus group was conducted in each country. Findings from these determined that individuals voiced common concerns: fatigue had not been addressed in the clinical setting - individuals surmised why this ...
Brief Fatigue Inventory (BFI) consist of 3 items that assess the severity of fatigue and 6 items that assess the impact of fatigue on daily functioning in a 10-points scale with 0 as no fatigue or does not interfere with daily functioning and 10 as bad fatigue or completely interferes. The scores for the six items were summed up to form a total interference score. The linear analogue scale of fatigue was a 10-points scale with 0 as no fatigue and 10 as bad fatigue. All scores were then transformed into 0 to 100 scale, with 100 as less fatigue/less interference. Change from baseline to week 4 was calculated by subtracting the baseline scores from the scores at week 4 ...
Change between Day 7 to Baseline in FACIT-F (Functional Assessment of Chronic illness Therapy-Fatigue) & FACT-G (Functional Assessment of Cancer Therapy-General) scores. Participants rate quality of life using FACT-G consisting of 33 questions with 5 domains assessing physical and social, emotional & functional well being & relationship with physician, remaining 5 assess extent to which each domain affects overall quality of life on 5-point scale from 0 (not at all) to 4 (very much); total score obtained by summing individual subscale scores (0-132). FACIT-F consists of 13 items where participants rate intensity of fatigue & its related symptoms on a scale of 0-4 from 0 not at all to 4 very much. The responses to FACIT fatigue questionnaire are each measured on 4‐point Likert scale with total score ranges from 0 to 52. High scores represent less fatigue. Reported is the mean change of the summed value of all reported scores for the FACT-G or the FACIT-F from baseline to Day 7 ...
OBJECTIVE: To investigate whether fatigue induced by an intermittent motor task in patients with cancer-related fatigue (CRF) is more central or peripheral....
You may expect disease activity and high levels of inflammation to cause your fatigue. Its true they account for much of it, but recent studies have shown that these factors dont tell the whole story. A 2016 study published in Rheumatology found that even when people are in clinical remission, they can still have significant fatigue.. If its not disease activity, what else could be causing your fatigue? In a study published in Arthritis Care & Research in 2016, Patricia Katz, PhD, professor of medicine at University of California San Francisco, and her colleagues found that fatigue may result from a constellation of factors that includes disease activity and pain, but also includes inactivity, depression, obesity and poor sleep.. Pinpointing which factors cause fatigue and which are a result of fatigue is difficult. Katz says the relationships may be cyclic: Fatigue may lead to inactivity and depression; then the inactivity worsens fatigue, depression and poor sleep.. Fatigue can be ...
Chronic fatigue related to cancer is a common syndrome during and following cancer treatment that manifests as a constant lack of energy that is not brought on by exertion, nor relieved by sleep. While cancer-related fatigue is not a well understood problem that can be associated with any single cause, consensus by health authorities is that it is a multifactorial problem involving the bodys reaction to both chemotherapy and radiation therapy; anemia resulting from decreased red blood cells that leaves tissues oxygen starved; and/or a decrease of vital nutrients.. One proposed source of a centuries-old treatment for people suffering from fatigue similar to that experienced by cancer patients is the use of adaptogens. Adaptogens are a class of herbal remedies noted for their potency as stress fighters capable of either bringing an overly stressed body back to its normal healthy state or in coping with stressors such as physical exertion, toxins, lack of sleep and psychological distress.. One of ...
The overall purpose was to explore the experience of living with chronic heart failure among patients in primary healthcare. Comparisons were made between patients with confirmed heart failure (HF, n=49), patients with symptoms indicating HF but with no HF (NHF, n=59), and a reference group (n=40). The mean age was 77 years. Patients in the HF and NHF groups had more general and physical fatigue, more reduced activity, worse physical quality of life and higher degree of depression compared with the reference group. The HF group had also higher degree of physical fatigue and worse physical quality of life than the NHF group. When comparing degrees of depression between the three groups and adjusting for fatigue, the physical dimension of fatigue was of greater importance in explaining group differences. In the HF group general fatigue was more closely related to limitations in role functioning for physical reasons than to reduced physical function per se. Women experienced more fatigue than men. ...
There is no way to know whether you will have fatigue or how bad it will be. But there are things you can do to help fight fatigue. Here are 7 tips to help manage cancer-related fatigue.
The etiology of severe fatigue in T1DM is not well understood. It seems obvious that physiological diabetes-related factors such as haemoglobin A1c (HbA1c) levels or variations in blood glucose levels are associated with fatigue. While fatigue is a classical presenting symptom of hyperglycaemia, in our cross-sectional study no relationship between glucose control (HbA1c levels) and fatigue severity was found [3]. Also, parameters gathered during continuous glucose monitoring such as the blood glucose variability were unrelated to persistent fatigue. Other diabetes-related factors were correlated to fatigue: the number of complications due to diabetes, diabetes-related distress and diabetes specific self-efficacy. Also, there was a univariate relationship between fatigue and somatic comorbidity. In a multiple regression, several cognitive behavioural factors were found to be potential determinants of fatigue: disrupted sleep-wake patterns, low physical activity, catastrophising thoughts about ...
OBJECTIVE: Cancer-related fatigue (CRF) is one of the most common unrelieved symptoms experienced by patients. CRF is underrecognized and undertreated due to a lack of clinically sensitive instruments that integrate easily into clinics. Modern computerized adaptive testing (CAT) can overcome these obstacles by enabling precise assessment of fatigue without requiring the administration of a large number of questions. A working item bank is essential for development of a CAT platform. The present report describes the building of an operational item bank for use in clinical settings with the ultimate goal of improving CRF identification and treatment. STUDY DESIGN AND SETTING: The sample included 301 cancer patients. Psychometric properties of items were examined by using Rasch analysis, an Item Response Theory (IRT) model. RESULTS AND CONCLUSION: The final bank includes 72 items. These 72 unidimensional items explained 57.5% of the variance, based on factor analysis results. Excellent internal ...
What is Adrenal Fatigue: Adrenal Gland Fatigue Symptoms, Test, and Treatments - Born to Be Boomers Could you be experiencing Adrenal Fatigue? See the symptoms.
Results Sjögrens patients had higher scores on all five fatigue dimensions (p,0.001) and lower scores on moderate and vigorous intensity activity (p≤0.001) compared with control participants. In the Sjögrens group, lower physical activity and higher activity avoidance and somatic focus were associated with more severe fatigue on most fatigue dimensions. For general fatigue and physical fatigue, especially the combination of low physical activity and high activity avoidance was associated with more severe fatigue (p,0.05).. ...
Fatigue in patients with cancers of the breast or prostate undergoing radical radiotherapy. To determine the prevalence, severity, and correlates of fatigue among patients with cancers of the Prostate or breast receiving high dose radiotherapy with curative intent, a prospective, questionnaire based study, evaluated a convenience sample of 62 patients who were about to start a course of radiotherapy. Patients were assessed immediately prior to treatment, and again within a week of finishing. Fatigue was assessed using the Fatigue Severity Scale (FSS) and the Bidimensional Fatigue Scale (BFS). Quality of life was assessed using the European Organisation for Research and Treatment of Cancer 30-item Quality of Life Questionnaire (EORTC QLQc30). Psychological distress was assessed using the Hospital Anxiety and Depression Scale (HADS). Personality Traits were assessed using the Eysenck Personality Inventory (EPI). Fatigue severity increased significantly on 3 out of the 5 assessment instruments ...
The objective of this study was to examine whether multiple sclerosis (MS)-related fatigue affects patients cognitive performance. Thirty patients who had substantial fatigue in conjunction with MS and who reported marked diurnal variability in the severity of their fatigue were tested on two occasions: during a period of high fatigue and during a period of relatively low fatigue. The order of these sessions was counterbalanced across patients. During both sessions, patients completed a questionnaire concerning their present state of fatigue and a battery of neuropsychological tests of planning, selective attention, and paired associate learning. Although patients confirmed greater fatigue during the period of high fatigue and felt they had performed more poorly during this period, there were no differences in cognitive performance that could be attributed to fatigue. Instead, all subjects showed improvement from the first to the second session regardless of whether the latter entailed a period ...
Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system is activated, heat shock proteins (HSPs) are produced to protect cells. Some extracellular HSPs appear to recognize cellular targets in the brain, and we hypothesize that fatigue may be generated by specific HSPs signalling through neuronal or glial cells in the central nervous system. From a cohort of patients with primary Sjögrens syndrome, 20 patients with high and 20 patients with low fatigue were selected. Fatigue was evaluated with a fatigue visual analogue scale. Plasma concentrations of HSP32, HSP60, HSP72 and HSP90α were measured and analysed to determine if there were associations with the level of fatigue. Plasma concentrations of HSP90α were significantly higher in patients with high fatigue compared with those with low fatigue, and there was a tendency to ...
The Fatigue Management Guide for Airline Operations supports Fatigue Risk Management Systems (FRMS), presenting the common approach of pilots, regulators and operators to this complex issues
Exercise and/or psychological interventions are more effective strategies than pharmaceutical interventions to reduce cancer-related fatigue.
Stone, P, Ream, E, Richardson, A, Thomas, H, Andrews, P, Campbell, P, Dawson, T, Edwards, J, Goldie, T, Hammick, M et al, Kearney, N, Lean, M, Rapley, D, Smith, AG, Teague, C and Young, A. (2003) Cancer-related fatigue - a difference of opinion? Results of a multicentre survey of healthcare professionals, patients and caregivers ...
The objective of this study is to develop a structured and evidence-based self-management program to cope with cancer-related fatigue and to assess the
Horneber, M; Fischer, I; Dimeo, F; Rüffer, J U; Weis, J Cancer-Related Fatigue: Epidemiology, Pathogenesis, Diagnosis, and Treatment Dtsch Arztebl Int 2012; 109(9): ; DOI: /arztebl
Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls. The fatigue level and cortisol slope significantly predicted sleep qual …
Fatigue is one of the most common problems for people receiving cancer treatment. Fatigue also can be a symptom of cancer. The fatigue is not the same as fatigue experienced by healthy people. It is described as feeling heavy, weak or worn out, and as having a complete lack of energy. Cancer fatigue can affect a persons quality of life, and can cause depression or other emotional problems.
The specific instruments used for the PROs in this evaluation are well described in published reports. The MOS-Sleep17 is one of several instruments designed to assess sleep and has been shown to have good psychometric properties.14 For measuring fatigue, Wolfe18 reviewed fatigue scales of suitable length or previously used for rheumatic diseases and concluded that the VAS fatigue measure was just as suitable for a simple assessment of fatigue as more extensive scales. However, when it is of interest, a greater understanding of fatigue may be found by evaluating and comparing different domains of fatigue, requiring a multidomain fatigue instrument. Preliminary work has shown that days of limited activity is a simple activity participation measure reflecting real changes in patient clinical status and quality of life, and it is valid, reliable, and sensitive to change.19 Assessment of quality of life is a central PRO. A consensus on the important domains include physical function, ...
OBJECTIVE: To examine patient-reported outcomes (PROs) in patients with different rheumatoid arthritis (RA) disease activity levels and identify residual symptoms. METHODS: Post hoc analyses of overall and Japanese data from two randomized controlled trials including RA patients with previous inadequate responses to methotrexate (NCT01710358) or no/minimal previous disease-modifying antirheumatic drug treatment (NCT01711359) (sponsor: Eli Lilly and Company). Week 24 assessments were disease activity (Simplified Disease Activity Index, Disease Activity Score/Disease Activity Score 28 joints-erythrocyte sedimentation rate) and PROs (pain visual analog scale [VAS], morning joint stiffness [MJS], Health Assessment Questionnaire-Disability Index, Functional Assessment of Chronic Illness Therapy-Fatigue, and Medical Outcomes Study Short Form 36 Health Survey Physical and Mental Component Scores ...
As many as 80 percent of people with lupus experience fatigue. For some people with lupus, fatigue is their main symptom. Fatigue can be debilitating, even to the point of forcing them to stop working.. It is unclear why extreme fatigue occurs in so many people with lupus. Several factors appear to be related to the experience of fatigue. These include disease activity and pain level, medications taken, age, poor mental and/or physical health, and the absence of sufficient social support.. Poor coping strategies, feelings of helplessness, depression or anxiety, smoking, and lack of exercise can also be related to lupus fatigue. Before a physician can conclude that fatigue is related to these factors, he or she will rule out any treatable causes of fatigue such as anemia, kidney failure, or hypothyroidism.. Physicians experienced with lupus recognize the harmful and even destructive effects that extreme fatigue can have, and research is underway to learn more about how to treat the ...
Objective. Sleep disturbance and chronic fatigue are common in rheumatoid arthritis (RA) and contribute to disability, symptomatology, and healthcare use. It has long been recognized in other populations that exercise can improve sleep and diminish fatigue. The effect of exercise on sleep quality and fatigue in RA has not been evaluated. Methods. Ours is a randomized controlled study in RA to determine the effect of an exercise program on sleep quality and fatigue. These were measured using the Pittsburgh Sleep Quality Index and the Fatigue Severity Scale. Patients were randomized to either a 12-week, home-based exercise intervention or usual care. The exercise program consisted of specific exercises to target individual deficiencies identified using the Health Assessment Questionnaire (HAQ) with cardiovascular work as per the guidelines. The intervention group was evaluated on a 3-week basis. Full evaluation was carried out at baseline and at 12 weeks. Results. Forty patients were randomized to ...
Context: High quality fatigue rating scales are needed to advance understanding of fatigue nd determine the efficacy of interventions. Several fatigue scales are used in Parkinsons isease, but few have been tested using modern psychometric methodology (Rasch analysis).. Objectives: To examine the measuring properties of the generic Functional Assessment of hronic Illness Therapy - Fatigue (FACIT-F) scale and the condition-specific 16-item arkinson Fatigue Scale (PFS-16) using Rasch analysis.. Methods: Postal survey data (n=150; 47% women; mean age, 70) were Rasch analyzed. FS-16 scores were tested according both to the original polytomous and the suggested lternative dichotomized scoring methods.. Results: The PFS-16 showed overall Rasch model fit whereas the FACIT-F showed signs of isfit, which probably was due to a sleepiness-related item and mixing of ositively/negatively worded items. There was no differential tem functioning by disease uration but by fatigue status (greater likelihood of ...
TY - JOUR. T1 - Chasing the silver bullet: measuring driver fatigue using simple and complex tasks. AU - Baulk, Stuart. AU - Biggs, Sarah. AU - Reid, Kathryn. AU - van den Heuvel, Cameron. AU - Dawson, Drew. PY - 2008. Y1 - 2008. N2 - Driver fatigue remains a significant cause of motor-vehicle accidents worldwide. New technologies are increasingly utilised to improve road safety, but there are no effective on-road measures for fatigue. While simulated driving tasks are sensitive, and simple performance tasks have been used in industrial fatigue management systems (FMS) to quantify risk, little is known about the relationship between such measures. Establishing a simple, on-road measure of fatigue, as a fitness-to-drive tool, is an important issue for road safety and accident prevention, particularly as many fatigue related accidents are preventable. This study aimed to measure fatigue-related performance decrements using a simple task (reaction time - RT) and a complex task (driving simulation), ...
This unit involves the skills and knowledge required to manage organisational fatigue management policy and procedures in accordance with relevant legislation and regulations.
Fatigue detection software is intended to reduce fatigue related fatalities and incidents. Several companies are working on a technology for use in industries such as mining, road- and rail haulage and aviation. The technology may soon find wider applications in industries such as health care and education. In an operational environment scenario where operating systems are dependent on human performance, fatigue can be defined as an inclination to degrade performance. Thus, fatigue is an indicator of baseline risk for the occurrence of errors and accidents. Globally mining operations are at risk of fatigued workers. Sleepiness and fatigue increase human error and contribute to accidents which can be fatal. Factors compounding fatigue levels in mine workers include; disruptions in circadian rhythms due to shift work, exposure to noise, vibration and chemicals, monotonous and repetitive nature of tasks and night shift driving. Studies recognise a connotation between lifestyle and fatigue. Mine ...
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Background. Fatigue is a frequently reported symptom in women following early breast cancer treatment and may be increased with adjuvant breast radiotherapy (RT). Within the START Quality of Life (QoL) sub study the effect of a range of clinical and psychological factors and symptoms on fatigue is investigated in women following RT for early stage breast cancer.. Method. A subgroup of women were recruited to the QoL study and completed the EORTC QLQ C-30, BR23 and HADS at baseline (after surgery +/- chemotherapy (CT) but before RT) and at 6, 12, 24 and 60 months. Fatigue was measured as a symptom subscale comprised of 3 individual items. The effect of age, time from surgery, type of surgery, CT, endocrine therapy, RT schedule and change over time were tested using a GEE model. Correlations between fatigue and anxiety, depression, insomnia and physical functioning were examined.. Results. 2180 (99%) women completed baseline QoL. Fatigue levels were highest pre RT (median 33.33) and decreased ...
PURPOSE: Fatigue is a symptom in patients with chronic gastrointestinal (GI) and liver diseases. Different instruments have been developed to assess the severity of fatigue and the 40-item Fatigue Impact Scale (FIS) is among the most widely used. Shorter versions of FIS include the 21-item Modified Fatigue Impact Scale (MFIS), and an eight-item version for everyday use. The study aimed to assess construct validity, reliability, and sufficiency of the raw score of the original FIS with 40 items, and examine the sufficiency of the 21 items from the Modified scale and the eight items of the Daily Fatigue Impact Scale (D-FIS), all of which are embedded in the 40-item scale ...
Introduction: Fatigue is the most troublesome untreated symptom during radical breast radiotherapy. This situation persists due to an uncertain aetiology and an inability to identify patients at high risk of experiencing significant fatigue during subsequent radiotherapy. Aetiological investigations of the current study concentrated on discriminating the radiotherapy-specific effects on fatigue, in a context encompassing multiple psychological and physiological covariates. Prognostic aspects sought to characterise a high-risk patient. Methods: The study cohort comprised 100 women, diagnosed with Stage 0 to IIA breast cancer, and prescribed standard whole breast irradiation to 40Gy in 15 fractions over three weeks. The use of systemic therapies was an exclusion criterion. A cytokine-induced sickness behaviour model framed the study investigations, and provided a theoretical link between localised radiotherapy and systemic fatigue. The outcome fatigue was assessed before, during and four weeks ...
The Fatigue Severity Score (FSS), the Fatigue Impact Scale (FIS), and the ModifiedFatigue Impact Scale (MFIS) are the most commonly used scales for fatigue assess-ment in MS patients.The FSS is composed of 9 items that assess perceivedSubjects are asked to assign a number from 1 (strongly disagree) to 7(strongly agree) stating their agreement with each statement.Responses aresummed and averaged, with a score of 4 or more indicating significant The FIS has been identified by the Multiple Sclerosis Council for Clinical Practice Guidelines as the most appropriate for assessing the impact of MS-related fatigueon quality of life.The FIS is a retrospective tool designed to evaluate fatigue duringthe past month. The FIS has separate subscales for physical, psychosocial, andcognitive functions, which span more than 40 statements.Subjects are asked toscore the effect of fatigue on those 4 dimensions using a 5-point scale from 0 (noproblem) to 4 (extreme problem). Since the FIS takes approximately 10 to ...
Our results suggest that ASA may improve some self-report measures of fatigue impact and severity. Baseline fatigue levels and outcomes were not affected by clinical variables, increasing the likelihood that we measured a common MS fatigue construct. We detected a treatment response despite confounders such as prior fatigue therapy use (33%) and current use of antidepressants or immunomodulatory drugs. We did not detect fatigue reduction on all outcome measures. Potential explanations include that individual scales measure diverse aspects of the fatigue construct, psychometric properties of scales differ, and characteristics of our patient sample may differ from other studies.5. Known pharmacological mechanisms of ASA, especially regarding fever, may be relevant to our results.6,7 ASA mediates the febrile response at the hypothalamus by irreversibly inhibiting cyclooxygenase and blocking prostaglandin E2 production. In MS, these effects could modulate hypothalamic output, thereby affecting ...
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PURPOSE: Fatigue is a distressing symptom occurring in more than 60% of patients with cancer. The CNS stimulants modafinil and methylphenidate are recommended for the treatment of cancer-related fatigue, despite a limited evidence base. We aimed to evaluate the efficacy and tolerability of modafinil in the management of fatigue in patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Adults with advanced NSCLC and performance status of 0 to 2, who were not treated with chemotherapy or radiotherapy within the last 4 weeks, were randomly assigned to daily modafinil (100 mg on days 1 to 14; 200 mg on days 15 to 28) or matched placebo. The primary outcome was change in Functional Assessment of Chronic Illness Therapy (FACIT) -Fatigue score from baseline to 28 days, adjusted for baseline fatigue and performance status. Secondary outcomes included safety and patient-reported measures of depression, daytime sleepiness, and quality of life. RESULTS: A total of 208 patients were randomly
Overcoming Barriers. Fatigue. Fatigue is common in MS, exercise and fatigue management education strategies will actually help your fatigue level in the long term(8).. Heat Sensitivity and MS. Physical and sensory symptoms may temporarily increase with small increases in environmental or body temperature. People with MS should be encouraged to keep cool and well hydrated during exercise sessions, for example using cool clothing and try to exercise inside or in the shade.. Research is continuing to address what exercise and strategies are best for fatigue and heat sensitivity; for now it is recommended to follow the Physical activity guidelines, remember to build up to these guidelines slowly. Stretching exercises are important too, and continuing these when fatigue levels, or temperatures, are high is still important.. Finding support. Support to help you exercise is not to be underestimated. Research indicates that learning about exercise, working with other to overcome your barriers and ...
Background: Fatigue is widespread in the population and a common complaint in primary care. Little is known about prevalence of fatigue in the population and its predictors. We aimed to describe the pattern of fatigue in the general population and to explore the associations with age, sex, socioeconomic status, self-reported physical activity, sitting time and self-rated health.. Methods: One thousand, five hundred and fifty-seven out of 2500 invited subjects in the Northern Sweden MONICA Study 2014, aged 25-74 years, filled out the Multidimensional Fatigue Inventory (MFI-20), consisting of four subscales: General fatigue (GF), Physical fatigue (PF), Reduced activity (RA) and Mental fatigue (MF). Questions regarding age, sex, socioeconomic status, physical activity, sitting time and self-rated health were also included.. Results: Higher age correlated significantly with lower fatigue scores for the GF and MF subscales. Women had higher fatigue scores than men on all subscales (p , 0.05). Among ...
Validated or standardized self-report questionnaires used in research studies and clinical evaluation of chronic fatigue syndrome (CFS) generally focus on the assessment of fatigue. There are relatively few published questionnaires that evaluate case defining and other accompanying symptoms in CFS. This paper introduces the self-report CDC CFS Symptom Inventory and analyzes its psychometric properties. One hundred sixty-four subjects (with CFS, other fatiguing illnesses and non fatigued controls) identified from the general population of Wichita, Kansas were enrolled. Evaluation included a physical examination, a standardized psychiatric interview, three previously validated self-report questionnaires measuring fatigue and illness impact (Medical Outcomes Survey Short-Form-36 [MOS SF-36], Multidimensional Fatigue Inventory [MFI], Chalder Fatigue Scale), and the CDC CFS Symptom Inventory. Based on theoretical assumptions and statistical analyses, we developed several different Symptom Inventory scores
Resveratrol (RES) is a well-known phytocompound and food component which has antioxidative and multifunctional bioactivities. However, there is limited evidence for the effects of RES on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of trans-RES on fatigue and ergogenic functions following physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered RES for 21 days at 0, 25, 50, and 125 mg/kg/day, which were respectively designated the vehicle, RES-25, RES-50, and RES-125 groups. The anti-fatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. The exhaustive swimming time of the RES-25 group (24.72 ± 7.35 min) was significantly (p = 0.0179) longer than that of vehicle group (10.83 ± 1.15 min). A trend analysis revealed that RES
To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls. Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected. Inclusion criteria in the present study were a baseline visit 6 months after disease onset, followed by an 18-year follow-up with available self-reported fatigue score (Fatigue Severity Scale (FSS), 1-7). Severe fatigue was defined as FSS ≥4. For comparison, Norwegian age and sex matched controls were used. Among 377 young adults with JIA, 26% reported severe fatigue, compared to 12% among controls. We found higher burden of fatigue among participants with sleep problems, pain, poor health, reduced participation in school/work, physical disability, active disease, or use of disease
|jats:p|In this study we set out to define the characteristics of autonomic subgroups of patients with Chronic Fatigue Syndrome (CFS). The study included 131 patients with CFS (Fukuda criteria). Participants completed the following screening symptom assessment tools: Chalder Fatigue Scale, Fatigue Impact Scale, Fatigue Severity Scale, Epworth Sleepiness Scales, the self-reported Composite Autonomic Symptom Scale. Autonomic parameters were measured at rest with a Task Force Monitor (CNS Systems) and arterial stiffness using an Arteriograph (TensioMed Kft.). Principal axis factor analysis yielded four factors: fatigue, subjective and objective autonomic dysfunction and arterial stiffness. Using cluster analyses, these factors were grouped in four autonomic profiles: 34% of patients had sympathetic symptoms with dysautonomia, 5% sympathetic alone, 21% parasympathetic and 40% had issues with sympathovagal balance. Those with a sympathetic-dysautonomia phenotype were associated with more severe disease,
Severe fatigue is a major health problem in fibromyalgia (FM). Obesity is common in FM, but the influence of adipokines and growth factors is not clear. The aim was to examine effects of exercise on fatigue, in lean, overweight and obese FM patients. In a longitudinal study, 48 FM patients (median 52 years) exercised for 15 weeks. Nine patients were lean (body mass index, BMI 18.5 to 24.9), 26 overweight (BMI 25 to 29.9) and 13 obese. Fatigue was rated on a 0 to 100 mm scale (fibromyalgia impact questionnaire [FIQ] fatigue) and multidimensional fatigue inventory (MFI-20) general fatigue (MFIGF). Higher levels in FIQ fatigue and MFIGF indicate greater degree of fatigue. Free and total IGF-1, neuropeptides, adipokines were determined in serum and cerebrospinal fluid (CSF). Baseline FIQ fatigue correlated negatively with serum leptin (r = -0.345; P = 0.016) and nerve growth factor (NGF; r = -0.412; P = 0.037). In lean patients, baseline MFIGF associated negatively with serum resistin (r = -0.694; P = 0.038
The aim of this study was to explore perceived fatigue, experienced functional limitations due to fatigue and clinical correlates in patients with Myotonic Dystrophy type 1 (DM1). In total, 32 consecutive patients with DM1 (14 women and 18 men) and 30 sex, age and education matched healthy control subjects participated. Perceived fatigue was rated on the Fatigue Impact Scale (FIS). Patients also completed a set of assessments aimed to characterize CTG-repeat size, muscle impairment, depression and cognitive functions. Non-parametric analysis were performed as appropriate, including Mann-Whitney U-test and Spearman correlation test. DM1 patients had higher FIS total score than healthy controls, suggesting higher fatigue levels. More specifically, DM1 patients scored higher on the FIS physical and psychosocial subscales than controls but not on the FIS cognitive scale. Scores on fatigue correlated significantly with muscle impairment and depression. Perceived fatigue is significantly more common in
Emergency response providers constitute an occupational group that is particularly vulnerable to the effects of sleepiness and fatigue. Considering the work they do, such a vulnerability poses significant risks to the health and safety of the responders themselves and of the general public. The development and implementation of fatigue management programs, plans, and policies for emergency response providers is therefore essential to protecting the health and safety of this critical segment of the workforce, as well as the people it serves.. In the short term, sleep loss and excessive periods of wakefulness are associated with sleepiness, which can cause both job performance problems (e.g., errors, failure of empathy) and work-related injuries (e.g., driving accidents), and possibly harm to the public if the emergency response provider has a failure in judgment or makes a technical error. In the longer term, working without adequate recovery between shifts can lead to fatigue, which can have ...
Cancer-related fatigue (CRF) is a common and distressing symptom of cancer and/or cancer treatment that persists for years after treatment completion in approximately one third of cancer survivors. Exercise is beneficial for the management of CRF, and general exercise guidelines for cancer survivors are available. There are multiple potential pathways by which exercise improves CRF, and cancer survivors with CRF are diverse with respect to cancer type, treatments and experienced side effects. While the general exercise guidelines are likely sufficient for most cancer survivors, tailoring of exercise interventions may be more effective in those with persistent fatigue. The primary aim of this research is to investigate the effect of a traditional vs. tailored exercise intervention on CRF severity in cancer survivors with persistent CRF. Cancer survivors (≥ 3 months and ≤ 5 years since primary treatment) who score ≤ 34 on the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F)
Publication Year and Month: 2013 12. Abstract: We evaluate the reliability, validity, and responsiveness of the Fatigue Severity Scale (FSS) and the Fatigue Impact Scale (FIS) and to determine whether these scales are potentially applicable for measuring fatigue in postpolio patients (PPS). After the Turkish adaptation of FSS and FIS using a forward-backward procedure, the scales were administered to 48 PPS patients without additional health problems that may induce fatigue. Reliability studies were carried out by determination of intraclass correlation coefficient and internal consistency by the Cronbach-α coefficient. Validity was tested by within-scale analyses and analyses against the external criteria including convergent validity and discriminant validity. Correlations with the Notthingham Health Profile (NHP), fatigue, pain and cramp severity (visual analog scale), and manual muscle testing were performed. Sensitivity to changes was determined by standardized response mean values. All ...
The prevalence of fatigue is high in patients with systemic lupus erythematosus (SLE). In this study, we used latent class analysis to reveal patterns of fatigue, anxiety, depression and organ involvement in a large international cohort of SLE patients.We used the Lupus BioBank of the upper Rhein to analyse patterns of fatigue using latent class analysis (LCA). After determining the optimal number of latent classes, patients were assigned according to model generated probabilities, and characteristics of classes were compared.A total of 502 patients were included. Significant fatigue, anxiety and depression were reported by 341 (67.9%), 159 (31.7%) and 52 (10.4%) patients, respectively. LCA revealed a first cluster (67.5% of patients) with low disease activity [median (25th-75th percentile interquartile range) Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA)-SLEDAI: 2 (0-4)], significant fatigue (55.5%, P ...
A recent University of Iowa study reveals a biological link between pain and fatigue and may help explain why more women than men are diagnosed with chronic pain and fatigue conditions like fibromyalgia and chronic fatigue syndrome.. Working with mice, the researchers, led by Kathleen Sluka, Ph.D., professor in the Graduate Program in Physical Therapy and Rehabilitation Science in the UI Roy J. and Lucille A. Carver College of Medicine, found that a protein involved in muscle pain works in conjunction with the male hormone testosterone to protect against muscle fatigue.. Chronic pain and fatigue often occur together -- as many as three in four people with chronic, widespread musculoskeletal pain report having fatigue; and as many as 94 percent of people with chronic fatigue syndromes report muscle pain. Women make up the majority of patients with these conditions.. To probe the link between pain and fatigue, and the influence of sex, the UI team compared exercise-induced muscle fatigue in male ...
A daily cup of flavonoid-rich cocoa may help ease fatigue in people with relapsing-remitting multiple sclerosis (RRMS), according to the results of a small clinical trial.. The study A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis was published in the Journal of Neurology, Neurosurgery & Psychiatry.. Fatigue is experienced by 90% of people with MS and, despite many approaches for fatigue management, exercise shows signs of being the most effective. However, even exercise has its limitations, and beneficial strategies are needed.. Dark chocolate containing 70 to 85% cocoa solids has shown success in improving fatigue in people with chronic fatigue syndrome. A small trial showed that consumption of flavonoid rich dark cocoa for a short term increased sleep quality and reduced fatigue in people with MS.. Flavonoids are a type of antioxidant found in several plant-based foods, such as dark ...
Study finds the Multidimensional Fatigue Inventory to be more valuable in assessing fatigue in fibromyalgia patients than the Fibromyalgia Impact Qu
Furthermore, age, gender, indication for transplantation, and time since transplantation were evaluated.. The team also assessed immunosuppressive medication, self-experienced disability, and health-related quality of life as potential associated factors.. The researchers found that 66% of all patients were fatigued, and 44% of all patients were severely fatigued.. Patients experienced physical fatigue with reduced activity rather than mental fatigue and reduced motivation.. Age, gender, self-experienced disabilities, and health related quality of life were factors that correlated with severity of fatigue.. Dr van den Berg-Emons team concluded, This study indicates that fatigue is a major problem in patients after liver transplantation, and no indications were found that complaints of fatigue improve over time. Liver transplant recipients experience physical fatigue and reduced activity rather than mental fatigue and reduced motivation. These findings have implications for the development of ...
Muscle fatigue reduces muscle strength and balance control in young people. It is not clear whether fatigue resistance seen in older persons leads to different effects. In order to understand whether muscle fatigue may increase fall risk in older persons, a systematic literature review aimed to summarize knowledge on the effects of lower extremity and trunk muscle fatigue on balance and functional tasks in older people was performed. Studies were identified with searches of the PUBMED and SCOPUS data bases. Papers describing effects of lower extremity or trunk muscle fatigue protocols on balance or functional tasks in older people were included. Studies were compared with regards to study population characteristics, fatigue protocol, and balance and functional task outcomes. Seven out of 266 studies met the inclusion criteria. Primary findings were: fatigue via resistance exercises to lower limb and trunk muscles induces postural instability during quiet standing; induced hip, knee and ankle muscle
Fatigue damage behaviors of four metal materials in the very high cycle fatigue (VHCF) regime have been studied using ultrasonic fatigue test and microstructure analysis. The results show that the fatigue crack initiation in VHCF regime could occur at subsurface non-defect fatigue crack origin (SNDFCO), where the accumulated cyclic strains or damage in the specimens were highly localized, especially in the materials with some softer phase, where the local maximum strain can be eight times higher than the average strain value in the specimen. This high strain localization can cause a local plasticity exhaustion that leads to a stress concentration and consequently fatigue crack initiation, and finally the formation of SNDFCO. For pure single phase austenitic material, strain localization can also occur due to dislocation accumulation at or near grain boundaries, which can become fatigue crack initiation origin in the VHCF regime. The results in this study show that fatigue damage and crack ...
Study Purpose: The effects of fatigue on human behavior, performance, and physiology are well understood and widely known. Excess fatigue arising from sleep loss, circadian disruption, and other factors tends to decrease alertness, impair performance, and worsen mood. As such, it is reasonable to expect that the performance, health, and safety of patrol officers, as well as police-community relations, are adversely affected by the fatigue an officer may experience. This study was undertaken to assess the connections between administratively controllable sources of fatigue among police patrol officers and problems such as diminished performance, accidents, and illness. The study sought to answer: (1) What is the prevalence of officer fatigue, and what are officers attitudes toward it? (2) What are the causes or correlates of officer fatigue? (3) How does fatigue affect officer safety, health, and job performance? and (4) Can officer fatigue be measured objectively? Study Design: Four police ...
The research investigated relationships between subjective fatigue, performance, and four physiological parameters: sinus arrhythmia, pupil behavior, blink rate, and tension of the neck muscles. Fatigue was induced by a doppler recognition task and rigid body posture. Performance was measured as the proportion of correct doppler identifications. There was no detection of a performance change during the two and one half-hour experimental sessions. Sinus arrhythmia and eyelid blink rate were also found to remain unchanged. An alteration was found in the measures of neck muscle tension levels, subjective fatigue, and the average pupil diameter. Subjective ratings of fatigue were found to be highly correlated with time-on-task and the electromyographic response of certain neck muscles. Polynomial regression indicated a significant linear relationship between the subjective ratings and the tension measured. (Author)*FATIGUE
muscle fatigue - MedHelps muscle fatigue Center for Information, Symptoms, Resources, Treatments and Tools for muscle fatigue. Find muscle fatigue information, treatments for muscle fatigue and muscle fatigue symptoms.
THURSDAY, Oct. 30, 2014 (HealthDay News) -- There are clear differences in the brains of people with chronic fatigue syndrome and the brains of healthy people, new research indicates. Scientists at Stanford University School of Medicine said their findings could help doctors diagnose this baffling condition and shed light on how it develops. People with chronic fatigue syndrome are often misdiagnosed or labeled as hypochondriacs. Using three types of brain scanning technologies, we found that [chronic fatigue syndrome] patients brains diverge from those of healthy subjects in at least three distinct ways, said the studys lead author, Dr. Michael Zeineh, assistant professor of radiology, in a Stanford news release.. Chronic fatigue syndrome affects up to 4 million people in the United States alone, says the U.S. Centers for Disease Control and Prevention. The condition, which causes debilitating and constant fatigue that persists for six months or more, is difficult to diagnose. Other ...
TY - GEN. T1 - Fatigue life properties and anomalous macroscopic fatigue fracture surfaces of low carbon steel JIS-SM490B in high-pressure hydrogen gas environment. AU - Ogawa, Yuhei. AU - Matsunaga, Hisao. AU - Yoshikawa, Michio. AU - Yamabe, Junichiro. AU - Matsuoka, Saburo. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Tension-compression fatigue tests using smooth specimens of low carbon steel JIS-SM490B were carried out in air and hydrogen gas environment under the pressure of 0.7 and 115 MPa at room temperature. In 0.7 MPa hydrogen gas, fatigue life curve was nearly equivalent to that in air. On the other hand, in 115 MPa hydrogen gas, fatigue life was significantly degraded in the relatively short fatigue life regime (e.g. Nf , 105). To clarify the effect of hydrogen environment on fracture process, fracture surfaces of these specimens were observed. In general, fatigue fracture process of steels with low or moderate strength is macroscopically divided into 3 stages. In the first stage (stage I), ...
Subjects in the experimental group received acupressure for 12 minutes per day, followed by a three-minute massage of the legs, three days a week, for four weeks. The acupressure points Zusanli, Sanyinjiao, Taixi and Yungchuan were deemed appropriate for easing fatigue and depression.. These points were pressed and rubbed using the pads of the fingers with a force of about three-to-five kilograms for five seconds, with a one-second release at the end. Each point was stimulated for three minutes. After 12 minutes of acupressure, subjects legs were massaged for three minutes.. Researchers used the revised Piper Fatigue Scale to measure fatigue, and the Chinese version of Becks Depression Inventory was used to measure depression, at the beginning and end of the four-week study. The results of the study revealed a significant decrease in perceived fatigue from the start to the finish of the study for subjects in the experimental group, whereas the control group showed no significant difference in ...
BACKGROUND: Checkpoint inhibitors have changed overall survival for patients with advanced melanoma. However, there is a lack of data on health-related quality of life (HRQoL) of long-term advanced melanoma survivors, years after treatment. Therefore, we evaluated HRQoL in long-term advanced melanoma survivors and compared the study outcomes with matched controls without cancer.. MATERIAL AND METHODS: Ipilimumab-treated advanced melanoma survivors without evidence of disease and without subsequent systemic therapy for a minimum of two years following last administration of ipilimumab were eligible for this study. The European Organization for Research and Treatment of Cancer quality of life questionnaire Core 30 (EORTC QLQ-C30), the Multidimensional Fatigue Inventory (MFI), the Hospital Anxiety and Depression Scale (HADS), and the Functional Assessment of Cancer Therapy-Melanoma questionnaire (FACT-M) were administered. Controls were individually matched for age, gender, and educational status. ...
Then there is the mental fatigue, which resembles the brain fog many lupus patients experience. I find mental fatigue very exasperating. I am a student of biology at university and compared to the focused, productive student I used to be at school ten years ago, I barely recognise myself. My brain feels like it is wading through mud and I feel like I am being constantly followed by a foggy cloud, which sucks the thoughts and life out of me. I find it very hard to concentrate and focus. I often end up reading the same thing over and over again and nothing will sink through. I seem to have no short-term memory and Im always forgetting what I am meant to be saying half-way through my sentences. I curse myself for this, though I know it is not my fault, because the fog makes me feel dumb and stupid. To those who dont understand, I appear slow, or anxious or bird-brained. Just like physical fatigue, this sort of fatigue is very difficult to explain to those who dont walk in our shoes. ...
The aim of this study was to identify subsets of patients with fibromyalgia with similar symptom profiles using the Outcome Measures in Rheumatology (OMERACT) core symptom domains. Female patients with a diagnosis of fibromyalgia and currently meeting fibromyalgia research survey criteria completed the Brief Pain Inventory, the 30-item Profile of Mood States, the Medical Outcomes Sleep Scale, the Multidimensional Fatigue Inventory, the Multiple Ability Self-Report Questionnaire, the Fibromyalgia Impact Questionnaire-Revised (FIQ-R) and the Short Form-36 between 1 June 2011 and 31 October 2011. Hierarchical agglomerative clustering was used to identify subgroups of patients with similar symptom profiles. To validate the results from this sample, hierarchical agglomerative clustering was repeated in an external sample of female patients with fibromyalgia with similar inclusion criteria. A total of 581 females with a mean age of 55.1 (range, 20.1 to 90.2) years were included. A four-cluster solution best
Severe fatigue is a common complaint among patients. Often, the fatigue is transient or can be attributed to a definable organic illness. Some patients present with persistent and disabling fatigue, but show no abnormalities on physical examination or screening laboratory tests. In these cases, the diagnosis of chronic fatigue syndrome (CFS) should be considered. CFS is characterized by debilitating fatigue with associated myalgias, tender lymph nodes, arthralgias, chills, feverish feelings, and postexertional malaise. Diagnosis of CFS is primarily by exclusion with no definitive laboratory test or physical findings. Medical research continues to examine the many possible etiologic agents for CFS (infectious, immunologic, neurologic, and psychiatric), but the answer remains elusive. It is known that CFS is a heterogeneous disorder possibly involving an interaction of biologic systems. Similarities with fibromyalgia exist and concomitant illnesses include irritable bowel syndrome, depression, and
Chronic fatigue syndrome (CFS) treatments alleviate chronic fatigue symptoms whether the causes of fatigue are viral (including the Epstein Barr virus) or due to another immune dysfunction syndrome. T...
Despite strong indications that fatigue is the most common and debilitating symptom after traumatic brain injury, little is known about its frequency, natural history, or relation to other factors. The current protocol outlines a strategy for a systematic review that will identify, assess, and critically appraise studies that assessed predictors for fatigue and the consequences of fatigue on at least two separate time points following traumatic brain injury. MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews, CINAHL, and PsycINFO will be systematically searched for relevant peer-reviewed studies. Reference lists of eligible papers will also be searched. All English language studies with a longitudinal design that focus on fatigue in adults with primary-impact traumatic brain injury will be included. Studies on fatigue following brain injury due to secondary pathological processes (intracranial complications, edema, ischemia/infarction, and systemic intracranial conditions) will be excluded.
Testing of large prototype lead zirconate titanate (PZT) stacks presents substantial technical challenges to electronic testing systems, so an alternative approach that uses subunits extracted from prototypes has been pursued. Extracted 10-layer and 20-layer plate specimens were subjected to an electric cycle test under an electric field of 3.0/0.0 kV/mm, 100 Hz to 10{sup 8} cycles. The effects of measurement field level and stack size (number of PZT layers) on the fatigue responses of piezoelectric and dielectric coefficients were observed. On-line monitoring permitted examination of the fatigue response of the PZT stacks. The fatigue rate (based on on-line monitoring) and the fatigue index (based on the conductance spectrum from impedance measurement or small signal measurement) were developed to quantify the fatigue status of the PZT stacks. The controlling fatigue mechanism was analyzed against the fatigue observations. The data presented can serve as input to design optimization of PZT ...
For a complete list, please see Holmes, et al.1 When you have ruled out all these conditions, there is a good chance you have a chronic fatigue patient on your hands. Many times the chiropractor is not the first professional a chronic fatigue (CF) patient has seen, often coming to us as a last resort. Also, many CF patients will enter our offices not for treatment of CF, but for relief of the musculoskeletal complaints that often accompany it. It is no secret that the allopathic practitioners who believe in CF have a difficult problem treating this condition. There are also many doctors who incorrectly call chronic fatigue patients depressed. Depression certainly can cause fatigue, and many fatigued patients are depressed, but we must find out which came first. Obviously, if every doctor in town tells you that you dont have a problem, it would be hard not to get depressed. Chronic Fatigue Syndrome (CFS) seems to be a postviral dysfunction of the bodys energy production system. It can affect ...
Hello Chronic Fatigue Syndrome or Chronic Fatigue Immune Dysfunction (CFIDS) became apparent in the mid 1980s as an epidemic characterized by debilitating fatigue and a host of other symptoms such...
New York, June 28 (IANS) Contrary to common perception, chronic fatigue syndrome may not be psychological in origin as researchers have now identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood. The findings suggest that changing diets, using prebiotics such as dietary fibers or probiotics could treat chronic fatigue syndrome, a condition where normal exertion leads to debilitating fatigue that is not alleviated by rest.. Physicians have been mystified by the disease as there are no known triggers, and diagnosis often requires lengthy tests administered by an expert.. Now, for the first time, Cornell University researchers described how they correctly diagnosed myalgic encephalomyeletis/chronic fatigue syndrome (ME/CFS) in 83 per cent of patients through stool samples and blood work, offering a noninvasive diagnosis and a step toward understanding the cause of the disease.. Our work demonstrates that the gut bacterial microbiome in chronic ...
Diagnosis and treatment of OC, mostly comprising debulking surgery and subsequent chemotherapy, entail severe symptom burden and a significant loss of patients quality of life.. Correspondingly, our study results indicate impairments for a wide range of somatic and psychological symptoms at the beginning of chemotherapy. Thus, at baseline, levels of anxiety and the prevalence of depressive symptoms were increased as reflected by self- as well as proxy-ratings. Similarly, fatigue (in terms of general fatigue, physical fatigue and reduced activity) was found to be high. Patients, however, recovered significantly over time up until aftercare. A strong improvement was not only found for anxiety and regarding the prevalence of depressive symptoms but also for almost all aspects of functioning covered by the QLQ-C30 as well as for fatigue (less pronounced for mental fatigue and reduced motivation). Both HADS as well as MFI-20 scores returned toward general population levels [30, 31].. From a clinical ...
Although physical and emotional fatigue is the most common side effect of cancer treatment, it remains underreported, underdiagnosed, and undertreated. Yet the exhaustion patients experience can significantly interfere with their daily functioning, and fatigue can persist for months or even years after treatment ends.. Of the non-pharmacologic interventions for cancer-related fatigue, researchers have found exercise to have the strongest potential to produce a therapeutic benefit. Exercise improves a wide range of biopsychosocial outcomes in patients with cancer. Studies have demonstrated that patients who exercise are less tired, less depressed, and sleep better. Of course, this can be counterintuitive for patients, who often reduce or stop exercising when undergoing fatigue-inducing treatments such as radiation. To counteract this impulse, oncology social workers at Mount Sinai Downtown Cancer Centers in New York City developed a quality improvement initiative to teach patients about the ...
Japan has been making research for fatigue and CFS a top priority, with economic implications estimated at $3.5 billion a year for chronic fatigue syndrome alone and $10.2 billion a year for general fatigue.. Japanese research teams (Hirohito Kiratsune, Yasuyoshi Watanabe and their colleagues) have created extensive studies into CFS. In June 2007, results from 15 of these studies were released in the Japanese Journal of Clinical Medicine Nippon Rinsho.. The Japanese studies have included researching the prevelance and diagnostic criteria in Japan; an overview of effective medical treatment and management; and research on discrete biochemical abnormalities apparent through specialized blood tests.. The individual studies address viral infections and herpesvirus reactivation, genetic background and marker genes, clinical features, neurotransmitter activity, serum properties and testing, sleep disturbance and evaluation of fatigue. Diagnosis and testing is the focus of several of the ...
In other words, when we have to cope with high stress situations our adrenal glands manufacture more adrenalin. If the stress is prolonged enough, the glands become exhausted, resulting in not only physical fatigue, but also depression and susceptibility to infection. Pregnenolone was tested with people with stressful job situations, such as airline pilots, and confirmed that psychomotor performance improved. It also enhanced the performance of various labour orientated jobs, including lathe workers and leather cutters. Performance was assessed on the basis of overall productivity, quality of work, frequency of mistake and mental and physical fatigue.. Rheumatoid arthritis ...
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We all know what it is to be exhausted: fatigue seems to be a normal part of human experience when we are overactive, have physical or emotional problems, face stress, or suffer from insomnia. Some of us, in fact, suffer from chronic fatigue syndrome, an illness characterized by pervasive fatigue that produces significant disability and lasts more than six months. In this important book, an eminent specialist in fatigue disorders-a physician who is sensitive and empathic to patients complaints-discusses all kinds of fatigue problems, explaining what fatigue is, what causes it, how to combat it, and what patients should know when consulting a doctor about symptoms.The book offers valuable advice on:• how to improve your sleep; • ways to find understanding and sympa thetic doctors; • self-help techniques to manage stress (the role of exercise, relaxation, and coaches); • the best medicines and ancillary techniques used by expert physicians to treat severe
chronic; fatigue; syndrome; myalgic; encephalopathy; ; Chronic Fatigue Syndrome is an illness which causes severe, disabling fatigue (tiredness) after physical and mental activity, far beyond what is usually felt. Resting and sleeping will help for a while, but even when people get enough sleep, they still feel tired and get exhausted quickly. Sometimes the pattern of health problems that are called chronic fatigue syndrome are called Myalgic encephalomyelitis (ME).. To find out more. Raising Children Network ...
ABSTRACT: Objective - Poor sleep quality has been linked to inflammatory processes and worse disease outcomes in the context of many chronic illnesses, but less is known in conditions such as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). This study examines the relationships between sleep quality, pro-inflammatory cytokines, and CFS/ME symptoms. Methods - Sixty women diagnosed with CFS/ME were assessed using the Pittsburgh Sleep Quality Index (PSQI), Fatigue Symptom Inventory (FSI) and Center for Disease Control and Prevention (CDC)-based CFS/ME symptom questionnaires. Circulating plasma pro-inflammatory cytokine levels were measured by ELISA. Multiple regression analyses examined associations between sleep, cytokines and symptoms, controlling for age, education, and body mass index. Results - Poor sleep quality (PSQI global score) was associated with greater pro-inflammatory cytokine levels: interleukin-1β (IL-1β) (β = 0.258, p = 0.043), IL-6 (β = 0.281, p = 0.033), and tumor ...
Amarkand tubers are routinely used by many Indian tribes as a specialized food for health and longevity but so far there is no scientific evidence for their activities. Taxonomically, Amarkand belong to genera Eulophia and Dioscorea. In this communication, comparative antifatigue potential of Amarkand was analyzed using forced swimming model in rats and evaluated using biomarkers of physical fatigue. Methanol extracts of tubers of D. bulbifera, E. ochreata, E. leghapanensis and bulbils of D. bulbifera exhibited rich polyphenolic content. D. bulbifera bulbils and E. ochreata significantly prolonged the swimming endurance time. Creatine kinase and urea nitrogen were significantly reduced by treatment of D. bulbifera bulbils and E. ochreata as compared to negative control. D. bulbifera bulbils effectively increased creatine (p < 0.001), lactate dehydrogenase (p < 0.01) and hemoglobin (p < 0.001) compared to negative control. D. bulbifera bulbils and E. ochreata treatments significantly increased glycogen
Chronic fatigue syndrome (CFS) is characterized by unexplained fatigue lasting for more than 6 months and accompanied by flulike symptoms. It most commonly affects women aged between 30 and 60 years. To date, clear diagnostic criteria allowing for unambiguous diagno-sis of CFS have not been established. We present a case of a 57-year-old woman with chronic fatigue syndrome in order to showcase the symptoms of this condition and propose a diagnos-tic protocol ...
In metal fatigue, it is common practice to distinguish between high-cycle fatigue (i.e. failure occurring after 10000-100000 cycles) and low-cycle fatigue. For elastic-plastic materials, there is an established correlation between fatigue and energy dissipation. In particular, high-cycle fatigue occurs when the energy dissipation remains bounded in time. Although the physical mechanisms in shape-memory alloys (SMAs) differ from plasticity, the hysteresis that is commonly observed in the stress-strain response shows that some energy dissipation occurs. It can be reasonably assumed that situations where the energy dissipation remains bounded are the most favorable for fatigue durability. In this communication, we present a direct method for determining if the energy dissipation in a SMA structure (submitted to a prescribed loading history) is bounded or not. That method is simple to use and could be relevant for the design of SMA systems with high durability requirements, such as stents. Some numerical
Looking for online definition of Cage Layer Fatigue in the Medical Dictionary? Cage Layer Fatigue explanation free. What is Cage Layer Fatigue? Meaning of Cage Layer Fatigue medical term. What does Cage Layer Fatigue mean?
Bennett RM. Fibromyalgia, chronic fatigue syndrome, and myofascial pain. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 274. Engleberg NC. Chronic fatigue syndrome. In: Bennett JE, ed. Mandell, Douglas, and Bennetts Principles and Practice of Infectious Diseases . 8th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2015:chap 133. IOM (Institute of Medicine). Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. Washington, DC: The National Academies Press; 2015. www.nationalacademies.org/hmd/~/media/Files/Report%20Files/2015/MECFS/MECFS_ReportBrief.pdf . Accessed April 20, 2016. Nijs J, Roussel N, Van Oosterwijck J, et al. Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice. Clin Rheumatol . 2013;32(8):1121-1129. PMID: 23639990 www.ncbi.nlm.nih.gov/pubmed/23639990 . Santhouse AM, ...