The Tasmanian devil is on the brink of extinction because of an unusual disease - a contagious cancer that is spreading very quickly. In some areas, more than 90% of the population has been wiped out. The disease is called Devil Facial Tumor Disease, or DFTD for short, and is characterized by malignant tumors - around the mouth and head - that behave as parasites and have caused an epidemic of cancer. The tumors are directly transmitted when the devils bite each other faces during fights - sometimes they bite off little pieces of tumor. When this happens, the cells reach the attackers bloodstream and, from there, its face. Once in the face, they start growing, producing a new tumor. Because the growth of tumors is not controlled by the devils immune system, the disease causes 100% mortality among infected devils. Tasmanian devils (Sarcophilus harrisii) are dog-sized carnivorous marsupials known for their black color, spine-chilling screeches and bad temper - they look and sound fierce.. Today, ...

SPEAKER: Associate Professor Janine Deakin, Institute for Applied Ecology, University of Canberra DATE: Friday, 12th August 2016 LOCATION: Geelong Campus at Waurn Ponds, Room KA4.207 TIME: 1:30pm Seminar will also be video linked to the following campuses: Melbourne Campus at Burwood, Burwood Corporate Centre (BCC) and Warrnambool Campus, Room J2.22 External visitors - wish to join us and connect…

Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...

The Tasmanian devil (Sarcophilus harrisii), the last remaining large marsupial carnivore, now faces extinction because of a strange and deadly infection: a transmissible cancer known as Devil Facial Tumor Disease. These tumor infections are apparently passed to other devils through bites during mating or during squabbles over carrion when devils gather to feed. In this…

The devil is apparently in the chromosomes.. In 1996 there were approximately 250,000 Tasmanian devils (Sarcophilus harrisii) in the wild, but by 2009 their numbers had crashed to less than 50,000 - some populations decreased by 90 per cent. The cause: the infamous Devil Facial Tumour Disease (DFTD), a transmissible cancer that has now decimated 85 per cent of Tasmanian devils in the wild.. It is estimated that over 100,000 animals have died from this unsightly disease and, despite all our hopes, its not showing any signs of slowing down. In fact, new research from the University of Sydney (USYD) suggests that this disease is able to survive indefinitely and could possibly get stronger in the future.. These hopes werent completely unfounded, the disease has been out there among the devils for 16 years and has divided millions of times, according to USYD postdoctoral research fellow Beata Ujvari. The low genetic material allows the disease to spread between individuals - its one of only three ...

Can cancer become an infectious disease? Usually with think of cancer as limited to the individual in whom the cancer formed. But what if cancerous cells could infect other individuals.. Here is a link to a story on the sad case of what happens when cancer learns to infect more than one individual: BBC News - Cull cannot save Tasmanian devil. Tasmanian facial tumor disease is passed from on Tasmanian devil to another. Usually we think of communicable diseases as being caused by bacteria or viruses but in this case the communicable disease is caused by cells of a cancerous tumor. When Tasmanian Devils bite each other during disputes they transmit the cells of the tumor to one another which then grow to the point that it interferes with their ability to see or eat causing their death.. This cancer has been the subject of quite a bit of study because the cancer cells seem to go unnoticed by the infected animal. There are many questions about how the cancer cells get around the immune system of ...

Can cancer become an infectious disease? Usually with think of cancer as limited to the individual in whom the cancer formed. But what if cancerous cells could infect other individuals.. Here is a link to a story on the sad case of what happens when cancer learns to infect more than one individual: BBC News - Cull cannot save Tasmanian devil. Tasmanian facial tumor disease is passed from on Tasmanian devil to another. Usually we think of communicable diseases as being caused by bacteria or viruses but in this case the communicable disease is caused by cells of a cancerous tumor. When Tasmanian Devils bite each other during disputes they transmit the cells of the tumor to one another which then grow to the point that it interferes with their ability to see or eat causing their death.. This cancer has been the subject of quite a bit of study because the cancer cells seem to go unnoticed by the infected animal. There are many questions about how the cancer cells get around the immune system of ...

Vražja lična tumorska bolest (engl. devil facial tumour disease, akr. DFTD) agresivni je nevirusni prenosivi parazitski rak, porijekla vjerojatno od Schwannovih stanica, koji pogađa tasmanske vragove.[1][2][3][4] Prvi službeni slučaj bio je opisan 1996. godine u Australiji. U sljedećem desetljeću bolest je opustošila populaciju tasmanskih divljih vragova s procjenama njezina smanjenja u rasponu od 20 % pa sve do 50 % na 65 % područja države.[5][6] Pogođene zgusnute populacije trpe mortalitet do 100 % unutar 12-18 mjeseci.[7] Bolest je uglavnom koncentrirana u istočnoj polovici Tasmanije. Vidljivi znakovi DFTD-a počinju s lezijama i kvrgama oko usta. One se razviju u maligne tumore koji se mogu širiti s lica na čitavo tijelo. Jednom kad se lezije pojave vragovi obično umiru unutar šest mjeseci zbog zatajenja organa, sekundarnih infekcija ili metaboličke gladi.[8] Tumori interferiraju u hranjenje i pogođena životinja može umrijeti od gladi. Vražja lična tumorska bolest ...

Transmissible cancers are incredibly rare in nature, yet have arisen in Tasmanian devils on at least two separate occasions. New research from the University of Cambridge identifies key anti-cancer drugs which could be trialled as a treatment for these diseases, which are threatening Tasmanian devils with extinction.

TY - JOUR. T1 - Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion. AU - Yu, Chuan Hang. AU - Chen, Hsin Ming. AU - Hung, Hsien Yen. AU - Cheng, Shih Jung. AU - Tsai, Tsuimin. AU - Chiang, Chun Pin. PY - 2008/6. Y1 - 2008/6. N2 - Our previous studies showed that oral verrucous hyperplasia (OVH) lesions can be successfully treated with a topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) protocol using a 635-nm light-emitting diode light source. In this study, we report the clinical outcomes of 36 OVH lesions treated by this protocol and assess what clinicopathological parameters of OVH lesions could influence PDT treatment outcomes. We found that all the 36 OVH lesions showed complete response (CR) after an average of 3.8 (range, 1-6) treatments of topical ALA-PDT. OVH lesions with an clinical appearance of a mass, with the greatest diameter 40 ...

tab-width: 4 -*- REMOTE_BASE=/remote/oyster/design REMOTE_BASE2=/remote/scarab MDLCNV=sdfModelExp MDLCNV_FLAGS=-b MOTCNV=sdfMotionExp MOTCNV_FLAGS=--optimize HUMAN_MODELS= \ human/pc.MB human/pc.TB human/pc.AB \ human/pcxxx.MB human/pcxxx.TB human/pcxxx.AB DEVIL_MODELS= \ devil/grp00/dummy.MB devil/grp00/dummy.AB \ # devil/grp01/amater.TB devil/grp01/amater.MB devil/grp01/amater.AB \ # devil/grp01/shasty.TB devil/grp01/shasty.MB devil/grp01/shasty.AB \ # devil/grp01/susano.TB devil/grp01/susano.MB devil/grp01/susano.AB \ # devil/grp01/kikuri.TB devil/grp01/kikuri.MB devil/grp01/kikuri.AB \ # devil/grp01/konoha.TB devil/grp01/konoha.MB devil/grp01/konoha.AB \ # devil/grp02/takemi.TB devil/grp02/takemi.MB devil/grp02/takemi.AB \ # devil/grp02/kufurn.TB devil/grp02/kufurn.MB devil/grp02/kufurn.AB \ # devil/grp02/karasu.TB devil/grp02/karasu.MB devil/grp02/karasu.AB \ # devil/grp02/gandha.TB devil/grp02/gandha.MB devil/grp02/gandha.AB \ # devil/grp02/jfrost.TB devil/grp02/jfrost.MB ...

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Tasmanian Devils were so named for their crabby, aggressive behavior (especially around food and mating time) and the absolutely bizarre sounds that they make. They are solitary, non-monogamous, nocturnal animals, and live in burrows. Devils eat a wide variety of other creatures, though they typically only hunt things that are smaller than themselves. They also consume carrion, and thanks to their powerful teeth and jaws, are able to completely consume an animal. Devils are at their most aggressive when feeding, as it is a time that the normally solitary creatures come together and (attempt to) share a meal ...

Histologic examination revealed intraepidermal vesicles containing acantholytic cells and ulceration. There was ballooning degeneration of keratinocytes. Also,

In the same way, the Thorny Devil sucks up water. So, if the Thorny Devil wants a drink, it can simply step in water and suck up the entire puddle and bring the water to its mouth with the tiny channels on its skin. It never even has to put its mouth in the water. This ability keeps the lizard alive, because any dew or moisture on plants or in the sand can be taken into its body this way.. Also, God gave the Thorny Devil several interesting ways to defend itself. Of course, the most obvious defensive tool of the Thorny Devil is its spiky skin. Just think, if you were a predator, would you want to eat something that looks like a pincushion, full of sharp spikes? Me neither. In addition to its spikes, the Thorny Devil has a false head on its neck just behind his real head. This false head is large and spiky. When the Thorny Devil is threatened, it can lower its real head between its front two legs and raise its false head to look like a head. By doing this, it protects its vital, important ...

Definition of blue devil in the online dictionary, Lexipedia. The meaning of blue devil. What does blue devil mean? blue devil synonyms, blue devil antonyms. Information about blue devil in the free online dictionary and thesaurus.

The Tasmanian Devil is afflicted by a unique type of contagious cancer that s never been seen in nature before Unless the spread of the cancer can be stopped the Devils could be wiped out with devas

Weiss GJ, Beck J, Braun DP, Bornemann-Kolatzki K, Barilla H, Cubello R, Quan W, Sangal A, Khemka V, Waypa J, Mitchell WM, Urnovitz H, Schütz E.. Clin Cancer Res. 2017 23(17):5074-5081. doi: 10.1158/1078-0432.CCR-17-0231. Epub 2017 Mar 20.. PMID: 28320758. Read article ...

Last Saturday was sunny and mild with a slight breeze, a perfect day for some football … if you were a Lancaster Red Devil. Not so much if you were a Mathews Blue Devil.. After losing its season opener to Sussex Central earlier last week, Lancaster scored at will last weekend, running away with a 61-14 win over Mathews, that wasnt even that close. The Blue Devils scored their second touchdown in the final minute. Mathews first score came on special teams and the Blue Devils never crossed midfield on offense in the first half.. Lancaster took a 14-0 lead early in the first quarter on a 23-yard TD run by Adam Wilmore and one of four touchdown carries by workhorse Chris Dameron. Dameron finished with 16 touches for an impressive 199 yards, four touchdowns and a two-point conversion.. Making his home debut as Lancasters new quarterback, Tafari Wall had 32 yards rushing with two touchdowns of 14 yards and one yard. He also threw for 147 yards, including 68 to Calvin Henderson on three catches. ...

Love and hatred are closely tied to actions. Now the actions we should engage in with respect to the devil are ones that are good for him, and hence they are more like loving than like hateful actions. For instance, we should reject the devils temptations. That is good, because by rejecting the temptations we make him be responsible for fewer evils than he would be responsible for if we yielded, and it is bad for one to be responsible for evils. We should shun the devils company. But to be in the devils company, we would have to be wicked. And it harms a person to be provided with wicked companions. Furthermore, we should strive to frustrate the devils wicked plans. While the frustration of ones plans may be bad for one in one way, in a more salient way, it is good for one when the plans are wicked. It is a bad thing for one to succeed at evil ...

The antimicrobial compounds are called cathelicidins and have been shown to kill MRSA, Vancomycin-resistant enterococcus, as well as fungi, called Candida.. Scientists believe devils evolved these peptides to help their young grow stronger and allow them to thrive in a relatively dirty environment.. ...

Hi there. My son Henry is almost 11 months. He went through a 14-week treatment of prednisolone for his facial hemangioma. 4 weeks of that were a weaning off period. While he was on the prednisolone, he took zantac (ranitidine) to counter act the medicine so he wouldnt get ulcers. He is also on propranolol for his hemangioma as well. Prior to this he had no feeding problems (we used to give him mylicon in his bottles as an infant). About 1 week into the weaning of the steroids, henry starting gagging all the time, like he was going to throw up and then sometimes he would throw up. This was off and on, but mostly gagging for 3 weeks straight. This started the week of June 15th. We went to a GI doc who advised us to up his dose of Zantac, that it had worn off thus causing reflux. We didnt start right away because he only seemed to be gagging for a few days straight. Last week was particularly bad. He started projectile vomiting and went up to 2x a day. We upped his dose of Zantac last monday.. ...

satan taught me on behance the devil. gif what i do during ap art need to change my url satan animated on gifer the devil. the blot says godzilla 89 from vs biollante satan devil

Could eating cheese after having breast cancer reduce your risk of dying from the disease? This was the spin put on research from a US Health Insurance company, that asked its patients what they ate. It found evidence of a link between high-fat dairy and an increased risk of death - but its not sufficient evidence to say for sure, and previous studies say otherwise. Its worth reading our previous post - What should you eat when youre being treated for cancer?, as well as our Healthy Living pages - but also this article we just published, about how the media talks about risks ...

In many animals, Toxoplasma infection causes nothing more than a mild case of the sniffles. If the animal is healthy, the immune system usually produces antibodies that keep the parasite under control. The parasite then goes into a relatively dormant state, forming invisibly tiny cysts mainly in the heart, lungs, brain, eyes, and spinal cord. While the cysts stay with the animal for life, they rarely cause any direct harm.But for some animals, infection can be deadly. If an animals immune system isnt quite up to the task, either through illness or stress, the initial infection can lead to toxoplasmosis. The disease has a range of debilitating symptoms, including anorexia, lethargy, reduced coordination, apparent blindness, enlarged lymph nodes, disorientation, breathing difficulties, jaundice, fever, abortion, and death ...

This is where this study could step in. It could provide a novel treatment approach where everything else is failing and could even help us tackle a global crisis. Drug-resistant bacteria are a global threat, and according to the World Health Organization, one we are not currently prepared to deal with.. Antimicrobial resistance (AMR) has developed to threaten the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. The magnitude of the issue is hard to estimate, but the fact is, pathogens seem to develop AMR faster than medicine can develop new strains of antibiotics, so it seems somewhat unavoidable to reach a tipping point one day; thats what a WHO report concludes as well.. With drug resistant infections expected to kill more people than cancer each year if things keep going as they are, we need a solution, and fast. The researchers are now investigating if the synthetic version of these peptides can be used safely in ...

We started with one stray, we ended up with fifteen. Smokey got pregnant, then two neighbors moved out leaving their pregnant cats behind and I found a stray kitten in the parking lot. We couldnt keep them all of course, but we kept them all together, weaned and litter boxed train them all and then took them to a local no kill shelter. Of the three...Dad kept Smokey and I kept her two boys Sass and BC. Someone BC about six months later and Sass passed three years ago...he was 18. We lost his adopted sister Dora, a shelter cat, six months later from heart disease. I hadnt planned on adopting again, two months later I came home with two kittens from the shelter...Pino and Sophie. They are terrors and just celebrated their second birthdays. They werent litter mates, but they are family. ...

Um, huh? First, the citation they use for the HIV claim is from 1999-indeed, at that point there was still a lot that was unknown about cross-species HIV transmission, but that was 12 years ago! The field has moved on since then. Im baffled as to what they mean by their first sentence-as far as I know, Virology doesnt consider anything-Virologists do, and why would this not be a zoonosis? Though I think direct transmission of cancer cells (like in the case of the Tasmanian devil transmissible cancer) would be unlikely, transmission of microbes which could lead to cancer development is certainly plausible and well within the realm of virology/bacteriology/etc. In my opinion, its infinitely more likely than the idea they also suggest of more directly carcinogenic animal secretions. There were also a number of limitations in the paper. Though they grouped frequency of sex with prostitutes into a more/less than ten times dichotomous variable, I dont see any similar dose analysis for the ...

A kind of clamping device comprising clamp base component (1) and the workpiece supporting plate (2) for being fixedly clamped to the clamping base component (1).Base component (1) is clamped characterized by multiple clamping bolts (43), these clamp the quantity that bolt (43) quantitatively correspond to clamping device (5), in place for fixedly clamping in each clamping device (5).For each clamping device (5) characterized by clamping bellmouth (6), the top side of the clamping bellmouth (6) forms the Z assembly bench for being used for workpiece supporting plate (2).The Z assembly bench for clamping base component (1) is formed by clamping multiple facial (11) at the top of bellmouth (6) at each, and wherein each facial (11) are both provided at least one outflow port (12) for cleaning medium.Each clamps bellmouth (6) and is both provided with the hollow protrusion (10) for extending to the downside for clamping base component (1) downward.

In 2006 I suffered a severe brain injury through an assault that was connected to my job in hospitality. I suffered multiple facial/cranial fractures ...

A customized patch treatment for basal cell carcinoma completely destroys facial tumors without surgery or major radiation therapy in 80 percent of patients studied, say researchers at the Society of Nuclear Medicines 2012 ...

Lyrics to Heart Of The Devil by Danzig: I am / Heart / Of the devil / I have / Heart / Of the / Devil / I can make a man / Freeze in his

The three adventures in The Devils Spine will be linked, but easily played alone. They take PCs all over the Ninth World (and beyond…but that would be telling), and get them involved in all kinds of strange, cool, and hopefully mind-bending experiences. While the corebook adventures set the stage for what a Numenera scenario might involve, The Devils Spine will stretch the boundaries in different ways. Because I know that beginning GMs have the adventures in the corebook, particularly the first, highly detailed, introductory one, I know I dont have to hold their hands too much, so to speak, with The Devils Spine adventures. I know that the GMs running these adventures will likely have some experience under their belts. Thus, these adventures will be provided with a sort of mid-range setting on our microscope. They will, however, also include seeds and other ideas for GMs who want to expand and create their own material. The idea is to make them useful to all different kinds of GMs. ...

Blue Eyed Devil lyrics by Soul Coughing: (M. Doughty) / Blue eyed devil. / Blue eyed devil. / Born to be a God among Salesmen. / Working

Dr. Burkitt was an Irishman who drove across sub-Saharan Africa in his beat up Ford pick up truck. He found many African kids between the ages of 5 and 8 years who had deadly facial tumors. He biopsied the tumor and it was found to be caused by a virus. Who would have thought that a virus could cause a cancer now called Burkitts lymphoma ...

Dr. Burkitt was an Irishman who drove across sub-Saharan Africa in his beat up Ford pick up truck. He found many African kids between the ages of 5 and 8 years who had deadly facial tumors. He biopsied the tumor and it was found to be caused by a virus. Who would have thought that a virus could cause a cancer now called Burkitts lymphoma ...

Our four-legged friends suffer from many of the same cancers that we do. But one type of dog tumor acts like no other: It's contagious. The tumor

ASM Press recently announced the publication of the book entitled Cryptococcus: From Human Pathogen to Model Yeast.Joseph Heitman, MD, PhD, James B. Duke Professor and Chair of the Department of Molecular Genetics and Microbiology, and four of his colleagues co-edited the 620-page book which focuses on the dramatic advance of Cryptococcus neoformansas a human fungal pathogen since its first clinical appearance in the 1890s ...

The present study has three main aims; a) to investigate the relationship between the tumor grade (TG), type (TT) and size (TS) on the renal carcinoma cancer (RCC) types, and demographic features of the patients such as gender and age, b) to find out the correlation between KI67 proliferation index and COX-2 and CD117 on the RCC, and c) to find out whether the immunohistochemical (IHC) reagents can determine the prognosis of some renal tumor diseases ...

Inclusion Criteria The study population consists of adult patients with advanced solid tumor disease that meet all of the following criteria to be enrolled into this study: 1. Age ≥ 18 years. 2. Patients with histologically confirmed solid tumors with a likelihood of expression of GNX102 targeted antigens, which are limited to: - colorectal - hepatocellular - non-small cell lung - gastric - breast - bladder - pancreatic - melanoma (cutaneous, acral, or mucosal) - esophageal - prostate - ovarian - cervical - epithelial uterine cancers. 3. Advanced, unresectable (local, regionally, recurrent not amenable to curative therapy) or metastatic disease that has no standard therapeutic option with a proven clinical benefit, are intolerant to or have refused all standard of care options with demonstrated clinical benefit. 4. Measurable disease per RECIST v 1.1 (primary or metastatic disease). 5. ECOG performance status of 0 or 1. 6. Baseline QTC interval of ≤ 480 msec using Fredericas formula. 7. ...

Germanys largest hospital for cancer patients was built on the campus of the University of Cologne - the Center for Integrated Oncology (CIO). Every year, -renowned experts treat around 24,000 patients who come to the University of -Cologne with cancer. All the clinics and institutes that used to live in different locations on the campus now work together centrally in one building, forming a strong alliance against cancer.. The CIO, with its seven upper floors and two lower floors, provides sufficient space for the diagnosis, treatment and research of tumour diseases on a total area of ​more than 13,500 square metres. The building is grouped around two -atriums, one of which is covered as an entrance atrium. This allows a maximum of naturally exposed and ventilated surfaces. Tunnels and bridges connect the CIO directly to the central hospital. A special feature is the cladding of the building: Red and green slats, which were mounted on the facade, give passersby the impression that the ...

Driver mutations in the EGFR, BRAF and KRAS genes represent a combined ~60% of all genomic variants driving oncogenesis of many solid tumor diseases, especially lung cancer. SeraCare is expanding its liquid biopsy portfolio with the addition of low-plex (single-gene) reference materials for clinically-validated biomarkers in these genes as ground-truth standards for molecular testing of circulating tumor DNA patient samples by PCR or NGS technologies. These products are designed for validation and standardization of clinical biomarkers in CLIA/CAP-accredited laboratory developed tests (LDTs).. The Seraseq ctDNA EGFR G719S Mutation Mix product has an allele frequency of 1%.. ...

AroCell AB (publ) is a Swedish company that develops standardized modern blood tests to support the prognosis and follow up of cancer patients. AroCells new technology is based on patented methods to measure Thymidine Kinase 1 (TK1) protein concentrations in a blood sample. The TK 210 ELISA test provides valuable information mainly about the condition of cancer patients. This may help clinicians to optimize treatment strategies and estimate the risk of recurrence of tumor disease during the monitoring of the disease. AroCell (AROC) is listed at Nasdaq First North Growth Market with Redeye AB as Certified Adviser: [email protected], +46 (0)8 121 576 90. For more information; www.arocell.com ...

Defining treatment-susceptible or -resistant populations of patients with cancer through the use of genetically defined biomarkers has revolutionized cancer care in recent years for some disease/patient groups. Research continues to show that histologically defined diseases are diverse in their expression of unique mutations or other genetic alterations, however, which presents opportunities for the development of personalized cancer treatments, but increased difficulty in testing these therapies, because potential patient populations are divided into ever smaller numbers. To address some of the growing challenges in biomarker development and clinical trial design, NCCN assembled a group of experts across specialties and solid tumor disease types to begin to define the problems and to consider alternate ways of designing clinical trials in the era of multiple biomarkers and targeted therapies. Results from that discussion are presented, focusing on issues of clinical trial design from the ...

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Professor Christof von Kalle has been director of the Department of Translational Oncology at National Center for Tumor Diseases (NCT) since 2005

We offer a broad range of services with focus on epigenetic diagnostics, detoxification and regeneration, therapies, immunotherapy and tumor diseases.

The Devils Creek Fire in Garfield County has grown to 11,000 acres, fire officials said Monday, forcing the closure of Devils Creek Road.

Shayne Gostisbehere is the proud owner of a new rookie record.. With his goal in the third period of Saturdays 2-1 OT loss to the Devils, the 22-year-old extended his point streak to 11 games, which is a record for rookie defensemen in the NHL.. Gostisbehere has an incredible 10 goals and 30 points in 35 games this season.. Gostisbeheres goal tied the game at one after Devils forward Joseph Blandisi scored this beauty in the first period:. ...

Rome2rio makes travelling from Stirling to Devils Pulpit easy.. Rome2rio is a door-to-door travel information and booking engine, helping you get to and from any location in the world. Find all the transport options for your trip from Stirling to Devils Pulpit right here. Rome2rio displays up to date schedules, route maps, journey times and estimated fares from relevant transport operators, ensuring you can make an informed decision about which option will suit you best. Rome2rio also offers online bookings for selected operators, making reservations easy and straightforward. ...