The review by Robinson and colleagues showed that the absence of SEPs assessed , 24 hours after the onset of coma was associated with a very poor prognosis. The specificity of this finding is excellent, although the sensitivity is rather low. In other words, many patients with coma and SEPs that are present also do very badly. The likelihood of waking up is largely determined by the cause of the coma-brain hemorrhage and anoxia are associated with the worst prognosis. Only in the case of adult anoxic encephalopathy, where none of the 336 patients with absent cortical SEPs woke up, would this finding allow for rapid treatment withdrawal. The authors correctly point out the self-fulfilling nature of applying these prognostic findings uncritically to new patients. A concern is the lack of discussion regarding the standardized performance of SEPs. No standards are offered on exactly how and when the tests should be done, although it is indicated that they should be performed , 24 hours after the ...
Fifty-four diabetic patients with or without clinical evidence of neuropathy and with no clinical evidence of CNS dysfunction were studied by somatosensory-evoked potentials after electrical stimulation of the median nerve at the wrist and recorded from the scalp electrode against a noncephalic reference. Peripheral conduction index, calculated as the distance from the wrist to the C7 spinous process divided by the P9 latency, was significantly decreased (P ,0.01) in diabetic patients (69.81 ± 6.47 m/s) compared with 28 age-matched nondiabetic subjects (76.85 ± 5.65 m/s). The P11-P13 interpeak latency, representative of the transit time from the dorsal column at the level of the sensory input into the cervical cord to the brain stem along the somatosensory pathways (CCT1), and the P13-N19 interpeak latency, representative of the transit time from the brain stem to the somatosensory cortex (CCT2), were significantly increased in diabetic patients (CCT1, 2.51 ± 0.63 ms; CCT2, 5.76 ± 0.92 ms) ...
Study Design.Retrospective analysis of a prospectively accrued series of 213 consecutive patients who underwent intraoperative neurophysiologic monitoring with electromyography and somatosensory-evoked potentials during thoracolumbar spine surgery.Objectives.To study the incidence of significant int
No doubt that PVCR is a very effective procedure for the correction of rigid deformities. It gives the surgeon freedom of manipulation after 360-degree release. But at the same time it is technically very demanding, lengthy and not without complications. It is one of the lengthiest and most tiring surgeries with reported mean operative time of more than 4 hours, and average blood loss of above 2000ml.13,15 This requires teamwork and great efforts from surgical and anaesthesia staff. One of the greatest concerns of a spine surgeon is new onset neurological deficit, which is not very uncommon in these patients. One study reported 3.4% occurrence of new neurological deficit in 321 patients with severe deformities treated with either PSO or PVCR.20 Patients were monitored during surgery with somatosensory-evoked potentials and Stagnara wake-up test. The high risk for new neurological deficit was pre-existing neurological deficit. A study reported the incidence of complications in 152 patients in ...
All afferent touch/vibration info ascends the spinal cord via the posterior (dorsal) column-medial lemniscus pathway via gracilis (T7 and below) or cuneatus (T6 and above).. Cuneatus sends signals to the cochlear nucleus indirectly via spinal grey matter, this info is used in determining if a perceived sound is just villi noise/irritation. All fibers cross (left becomes right) in the medulla.. The postcentral gyrus includes the primary somatosensory cortex (Brodmann areas 3, 2 and 1) collectively referred to as S1.. BA3 receives the densest projections from the thalamus. BA3a is involved with the sense of relative position of neighboring body parts and amount of effort being used during movement. BA3b is responsible for distributing somato info, it projects texture info to BA1 and shape + size info to BA2.. Region S2 (secondary somatosensory cortex) divides into Area S2 and parietal ventral area. Area S2 is involved with specific touch perception and is thus integrally linked with the amygdala ...
Sigma-Aldrich offers abstracts and full-text articles by [Faith A Bazley, Anil Maybhate, Chuen Seng Tan, Nitish V Thakor, Candace Kerr, Angelo H All].
Functional resistance to graded hypotensive ischemia of various segments of the somatosensory pathway was determined in anesthetized cats by repeated concurrent recordings of regional blood flow measured by hydrogen clearance, and evoked potentials (EPs), of dorsal horn of lumbar spinal cord and cerebral cortex. During normal resting CNS blood flow (CBF), there were significant successive reductions of EP amplitudes, recorded from presynaptic spinal components (634, 424-949 microV; re-linearized mean and 95% confidence limits of log-transformed data) compared to postsynaptic spinal (359, 247-522 microV) and presynaptic cortical (50, 32-79 microV) and to postsynaptic cortical components (33, 22-50 microV). During ischemia amplitudes of EPs in spinal cord and cerebral cortex showed significantly different behaviors. The presynaptic spinal component was virtually independent of regional blood flow down to 12 percent of resting values, the postsynaptic cortical component exhibited strongest positive ...
Objective: Somatosensory evoked potentials (SEPs) enable the investigation of thalamocortical and early cortical processing. Previous studies reported alterations of SEPs in patients with schizophrenia as well as in individuals in the prodromal stage. Moreover, cannabis use as an environmental risk factor for the development of schizophrenia has been demonstrated to influence SEP parameters in individuals at risk to develop psychosis. The aim of this study was to explore the course of SEP changes and the impact of concomitant cannabis use in individuals at risk to develop psychosis who sought medical help.Methods: Median nerve SEPs including high-frequency oscillations (HFOs) superimposed on the primary cortical response (N20) were investigated using multichannel EEG in individuals (n = 54 at baseline) remaining at risk to develop psychosis at follow-up after 1 year (high-risk: n = 19; ultra-high-risk: n = 27) vs. subjects with conversion to psychosis (n = 8) and a healthy control group (n = 35).
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Slow-adapting type I (SA-I) afferents deliver sensory signals to the somatosensory cortex during low-frequency (or static) mechanical stimulation. It has been reported that the somatosensory projection from SA-I afferents is effective and reliable for object grasping and manipulation. Despite a large number of neuroimaging studies on cortical activation responding to tactile stimuli mediated by SA-I afferents, how sensory information of such tactile stimuli flows over the somatosensory cortex remains poorly understood. In this study, we investigated tactile information processing of pressure stimuli between the primary (SI) and secondary (SII) somatosensory cortices by measuring effective connectivity using dynamic causal modeling (DCM). We applied pressure stimuli for 3 s to the right index fingertip of healthy participants and acquired functional magnetic resonance imaging (fMRI) data using a 3T MRI system. DCM analysis revealed intra-hemispheric effective connectivity between the contralateral SI
The effect of electrical somatosensory stimulation on motor performance of the affected hand was investigated in 12 chronic subcortical stroke subjects. Subjects performed index finger and hand tapping movements as well as reach-to-grasp movements with both the affected and unaffected hand prior to (baseline conditions) and following (i) two hours of electrical somatosensory stimulation (trains of 5 pulses at 10 Hz with 1 ms duration delivered at 1 Hz with an intensity on average 60% above the individual somatosensory threshold) of the median nerve of the affected hand or (ii) two hours of idle time on separate occasions at least one week apart. The order of sessions was counterbalanced across subjects. Somatosensory stimulation of the median nerve of the affected hand, but not a period of idle time, enhanced the frequency of index finger and hand tapping movements and improved the kinematics of reach-to-grasp movements performed with the affected hand, compared to baseline. Somatosensory ...
Somatosensory Cortex: The primary somatosensory cortex is located in the postcentral gyrus, and is part of the somatosensory system.
It is established that reward can influence a wide range of overt human behaviors (Dehaene and Changeux, 2000; Glimcher and Rustichini, 2004; Pessiglione et al., 2006), with much recent interest in the neural basis of such reward influences (Platt and Glimcher, 1999; Schultz, 2000; Glimcher, 2001; Sugrue et al., 2004). Here, we extend the domain of reward-related influences to include early somatosensory processing, showing that reward can augment somatosensory performance (Fig. 1 b) and influence activity in human somatosensory cortex [Figs. 2 (right), 3 a-c, 4 a, 5 (right)]. Particularly striking is our observation that primary somatosensory cortex contralateral to the judged finger showed elevated hemodynamic response (or "reactivation" of stimulus-responsive regions) for reward delivery at trial end [Figs. 2 (right), 3], even though rewards for a correct somatosensory judgment were signaled only visually at this point. Moreover, this reactivation of primary somatosensory cortex increased ...
We used fMRI to establish whether attention to touch enhances somatosensory cortical activity. Subjects received somatosensory and visual stimulation and were instructed to attend selectively to one modality during alternating stimulus detection periods interspersed with rest periods during which no stimulus was delivered. The maximum signal change for each task versus rest was measured in anatomically defined regions of interest for each subject. Attended touch produced greater signal change than unattended touch in primary (S1) and secondary (S2) somatosensory cortex. In contrast to the conclusions of some previous studies, we found that the enhancement of activation with attention was at least as great in S1 as in S2. The attentional effect was unilateral in S1 and bilateral in S2 and the somatosensory insula.
OBJECTIVE: Laser stimulation of Adelta-fibre nociceptors in the skin evokes nociceptive-specific brain responses (laser-evoked potentials, LEPs). The largest vertex complex (N2-P2) is widely used to assess nociceptive pathways in physiological and clinical studies. The aim of this study was to develop an automated method to measure amplitudes and latencies of the N2 and P2 peaks on a single-trial basis. METHODS: LEPs were recorded after Nd:YAP laser stimulation of the left hand dorsum in 7 normal volunteers. For each subject, a basis set of 4 regressors (the N2 and P2 waveforms and their respective temporal derivatives) was derived from the time-averaged data and regressed against every single-trial LEP response. This provided a separate quantitative estimate of amplitude and latency for the N2 and P2 components of each trial. RESULTS: All estimates of LEP parameters correlated significantly with the corresponding measurements performed by a human expert (N2 amplitude: R2=0.70; P2 amplitude: R2=0.70; N2
The third and largest section of the text is what really distinguishes this work from other texts covering the same topic. Although it is well and good to provide theoretical background and outcome data for each monitoring modality, the anesthesiologist will not really learn how to optimize his or her practice for use during monitoring and will not really understand just how important this monitoring can be to the patients well-being until real clinical experience is gained with monitoring. The anesthesiologist will be convinced of the importance of controlling for confounding factors during critical monitoring periods upon actually seeing a surgeon place an aneurysm clip (which appears by all assessments to be well placed) cause a loss of cortical somatosensory evoked response that returns after the clip is adjusted. Each chapter focuses on neurologic monitoring during cases the practicing neuroanesthesiologist is likely to encounter. Considering this section as a whole, nearly all common ...
Using EEG and fMRI, we investigated neural signatures of unconscious cortical stimulus processing after subthreshold somatosensory stimulation. The goal was to identify mechanisms that (1) prevent access to conscious perception and (2) underlie behavioral consequences of subthreshold stimulation. The main findings are as follows. Subthreshold electrical single pulses generate an SEP peaking at 60 ms (P1), the amplitude of which is weaker than the P1 after suprathreshold stimulation and occurs ∼10 ms later. No subsequent SEP components were detected. Subthreshold stimulation does not desynchronize Mu-rhythm; rather, there is a transient increase between 50 and 400 ms. Subthreshold stimulation decreases centrality of the contralateral SI hand area predominantly driven by reduced functional connectivity to frontoparietal areas.. Previous studies on the detection of near-threshold (Zhang and Ding, 2010, Auksztulewicz and Blankenburg, 2013) and masked suprathreshold (Schubert et al., 2006) stimuli ...
The somatosensory cortex controls the bodys sense of touch. This part of the brain is located behind the frontal lobe where the motor controls are located. The area is called the parietal lobe, and...
Secondary thalamic nuclei may provide stronger, longer-lasting input to superficial layers of primary sensory cortex than other cortical areas can.
Key to understanding somatosensation is the form of how the mechanical stimuli are represented in the evoked neuronal activity of the brain. Here, we focus on studies that address the question of which components of the evoked neuronal activity in the somatosensory system represent the stimulus features. We review experiments that probe whether these neuronal representations are essential to somatosensation. We also discuss recent results that suggest how the somatosensory stimuli are represented in the brain during short-term memory. Finally, we review data that show the neuronal correlates of a decision during somatosensory perception. (C) 2002 Elsevier Science B.V. All rights reserved. ...
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Somatosensory (SI & SII) and Motor (MI) Cortices.Panels A and B - SI and MI in this study were defined as the central sulcus including its posterior wall, a
Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.. ...
The Davidson Lab uses a diverse array of methods to investigate the encoding and plasticity of somatosensory information in the nervous system. ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Kristt, D A. and Waldman, J V., "Developmental reorganization of acetylcholinesterase-rich inputs to somatosensory cortex of the mouse." (1982). Subject Strain Bibliography 1982. 4234 ...
In the somatosensory system, it is well known that the bilateral secondary somatosensory cortex (SII) receives projections from the unilateral primary somatosensory cortex (SI), and the SII cortex, in turn, sends feedback projections to SI. Most neuroimaging studies have clearly shown bilateral SII activation using only unilateral stimulation for both anatomical and functional connectivity across SII subregions. However, no study has unveiled differences in the functional connectivity of the contra- and ipsilateral SII network that relate to frontoparietal areas during tactile object recognition. Therefore, we used event-related functional magnetic resonance imaging (fMRI) and a delayed match-to-sample (DMS) task to investigate the contributions of bilateral SII during tactile object recognition. In the fMRI experiment, fourteen healthy subjects were presented with tactile angle stimuli on their right index finger and asked to encode three sample stimuli during the encoding phase and one test stimulus
In the mammalian neocortex, segregated processing streams are thought to be important for forming sensory representations of the environment, but how local information in primary sensory cortex is transmitted to other distant cortical areas during behaviour is unclear. Here we show task-dependent activation of distinct, largely non-overlapping long-range projection neurons in the whisker region of primary somatosensory cortex (S1) in awake, behaving mice. Using two-photon calcium imaging, we monitored neuronal activity in anatomically identified S1 neurons projecting to secondary somatosensory (S2) or primary motor (M1) cortex in mice using their whiskers to perform a texture-discrimination task or a task that required them to detect the presence of an object at a certain location. Whisking-related cells were found among S2-projecting (S2P) but not M1-projecting (M1P) neurons. A higher fraction of S2P than M1P neurons showed touch-related responses during texture discrimination, whereas a higher ...
Author: Spitzer, Bernhard et al.; Genre: Journal Article; Published in Print: 2014-05; Keywords: Working memory; Tactile; fMRI; Connectivity; Stimulus coding; Title: Maintenance and manipulation of somatosensory information in ventrolateral prefrontal cortex
The postcentral gyrus is a prominent gyrus in the lateral parietal lobe of the human brain. It is the location of the primary somatosensory cortex, the main sensory receptive area for the sense of touch. Like other sensory areas, there is a map of sensory space in this location, called the sensory homunculus. The primary somatosensory cortex was initially defined from surface stimulation studies of Wilder Penfield, and parallel surface potential studies of Bard, Woolsey, and Marshall. Although initially defined to be roughly the same as Brodmann areas 3, 1 and 2, more recent work by Kaas has suggested that for homogeny with other sensory fields only area 3 should be referred to as "primary somatosensory cortex", as it receives the bulk of the thalamocortical projections from the sensory input fields. ...
Hoffer, Z.S, J.E. Hoover, and K.D. Alloway (2003) Sensorimotor corticocortical projections from rat barrel cortex have an anisotropic organization that facilitates integration of inputs from whiskers in the same row. Journal of Comparative Neurology, 466:525-544.. Alloway, K.D., Z.S. Hoffer, and J.E. Hoover (2003). Quantitative comparisons of the topographic organization in the ventrobasal complex and posterior nucleus of the rodent thalamus. Brain Research, 96:54-68.. Hoover, J.E., Z. Hoffer, K.D. Alloway (2003) Projections from primary somatosensory cortex to the neostriatum: the role of somatotopic continuity in corticostriatal convergence. Journal of Neurophysiology, 89:1576-1587.. 2000. Overlapping corticostriatal projections from the rodent vibrissal representations in primary and secondary somatosensory cortex. Journal of Comparative Neurology, 426:51-67. (with K. Alloway, J. Mutic, and Z. Hoffer).. 1999. The organization of cerebellar and basal ganglia outputs to primary motor cortex as ...
Elife. 2016 Dec 19;5. pii: e22866.. Semi-intact ex vivo approach to investigate spinal somatosensory circuits.. Hachisuka J, Baumbauer KM, Omori Y, Snyder LM, Koerber HR, Ross SE.. Insight into B5-I spinal interneurons and their role in the inhibition of itch and pain.. Chiang MC, Hachisuka J, Todd AJ, Ross SE.. Keratinocytes can modulate and directly initiate nociceptive responses.. Baumbauer KM, DeBerry JJ, Adelman PC, Miller RH, Hachisuka J, Lee KH, Ross SE, Koerber HR, Davis BM, Albers KM.. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.. Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M.. Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes.. Nakahara T, Mitoma C, Hashimoto-Hachiya A, Takahara M, Tsuji G, Uchi H, Yan X, Hachisuka J, Chiba T, Esaki H, ...
Stroke are the main causes of motor disability among adults and are expected to impose an increasing social and economic burden for our Country. The impact of stroke on patients is enormous, with negative ramifications on the persons participation in social, vocational, and recreational activities. It is the primary cause of long-term disability in these countries. At the present stage, it is well known that control of balance during upright standing depends upon the central integration of afferent information from vestibular, somatosensory (proprioceptive, tactile), and visual systems, which constitute a multilink neural network for the control of neck, hip, and ankle joints. More recently, it has been studied at the level of cerebral cortex; vestibular inputs would reach face/neck representation of primary somatosensory cortex and would be then integrated with visual and somatosensory inputs in intraparietal, posterior end of the insula and medial superior temporal cortices. Remarkably, ...
Stroke are the main causes of motor disability among adults and are expected to impose an increasing social and economic burden for our Country. The impact of stroke on patients is enormous, with negative ramifications on the persons participation in social, vocational, and recreational activities. It is the primary cause of long-term disability in these countries. At the present stage, it is well known that control of balance during upright standing depends upon the central integration of afferent information from vestibular, somatosensory (proprioceptive, tactile), and visual systems, which constitute a multilink neural network for the control of neck, hip, and ankle joints. More recently, it has been studied at the level of cerebral cortex; vestibular inputs would reach face/neck representation of primary somatosensory cortex and would be then integrated with visual and somatosensory inputs in intraparietal, posterior end of the insula and medial superior temporal cortices. Remarkably, ...
I should note that the homework question states If a sensory neuron for touch located in the elbow was somehow rewired to a persons primary olfactory cortex, then every time the persons elbow was touched, they would perceive some smell., which appears contradictory to von Melchner et als statement rewired ferrets respond as though they perceive the stimuli to be visual rather than auditory. The word perceive may be carrying different meanings here. Perhaps better language would be the animal/patient is able to receive visual/somatosensory information through its/his auditory cortex, and the information is sufficiently fine that it/he can respond with appropriate behaviour to an appropriate visual/somatosensory stimulus ...
2001; Radovanovic et al. 2002). Furthermore, our time course of SMA activity was similar to that elicited by median nerve stimulation and PM using EEG and electrocorticography. We located the source of activity in the posterior wall of the postcentral Belinostat HDAC fissure 64-114 msec following PM, and this ECD location was 23.8 mm posterior, 19.3 mm medial,. and 9.0 mm superior to the source estimated at N20m. Using BESA analysis, Hoshiyama et al. (1997b) reported that the ECD location of PPC was 24 mm posterior, 19 mm medial, and 26 mm superior to the Inhibitors,research,lifescience,medical S1 hand area (Hoshiyama et al. 1997b). Areas 5 and 7 in the posterior wall of the postcentral fissure are considered to be at a higher level than S1 in the processing of somatic information (Duffy and Burchfiel 1971; Sakata et al. 1973; MacKay et al. 1978). Prevosto et al. (2011) identified direct and polysynaptic somatosensory pathways from areas 2 Inhibitors,research,lifescience,medical and 3a to PPC, ...
The scientists used a computer program to average the PET data from the subjects within each group, and then compared the obese subjects average with the normal subjects result. The program produced three-dimensional images highlighting areas where the obese group had higher metabolic activity than the normal-weight group. The scientists then superimposed these images onto a magnetic resonance image (MRI) of the whole brain, as well as a diagram of the brain s somatosensory cortex, known as a homunculus. A homunculus graphically illustrates the relative number of sensory nerves innervating various parts of the body as well as where the input from these nerves is received on the somatosensory cortex. The overlapping images revealed hot spots indicating obese subjects higher metabolic activity in the regions of the parietal cortex where somatosensory input from the mouth, lips, and tongue is received. This is also an area involved with taste perception. The enhanced activation of these parietal ...
Hitherto, intraoperative SEP monitoring has mainly depended on time domain measurements of the latency and amplitude in the initial response peak. Under clinical conditions, SEP signals are usually accompanied by numerous noise signals from the patient and the environment.2 For example, the cortical peaks are often modulated by slow waves, which may result in apparent reductions or increases in amplitude, depending on the position of the peak relative to the ascending or descending part of the slow wave. Even with averaging signal enhancement, identification of SEP peaks is sometimes not an easy task and often requires trained personnel.1, 6 False outcomes in SEP monitoring are probably caused by interpretation of technically unsatisfactory recordings.1, 13, 14 Some false monitoring outcomes reflect contaminated SEP signals.3. Time-frequency analysis can separate the useful information from noise in time-frequency space so as to avoid the variability caused by noise. Our results show that the ...
PRF readers can get free access to a selected Journal of Pain paper each month, thanks to the American Pain Society. Get the free full text of the selection from the December 2017 issue here.. ...
Show moreOBJECTIVE: With aging, skin is likely to become less hydrated, thereby increasing its resistance to electrical current. This, rather than sensorial/perceptual differences per se, may be the primary cause of differences between younger and older adults in somatosensorial perception in response to electrical stimuli. METHODS: To assess whether aging alters the perception of electrical stimulation, we compared the perceived intensity of electrical stimuli in younger and older subjects, considering both setpoint intensities and the actual intensities of the current passing through subjects skin. This resulted in reliable information about electrical somatosensory perception in both groups at equivalent received amounts of current. Somatosensory evoked potentials (SEPs) enabled the objective evaluation of somatosensitivity in both groups. RESULTS: At equivalent received intensities, the mean ratings were significantly lower in older than in younger subjects. SEPs confirmed these results, ...
Electrophysiology-delivery of fluorescent viral vectors-and two-photon microscopy were used to demonstrate the rapidity of axonal restructuring of both excitatory and inhibitory neurons in rodent cortical layer II/III following alterations in sensory experience.
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans. Tyler, W.J., A. Boasso, H.M. Mortimore, R.S. Silva, J.D. Charlesworth, M.A. Marlin, K.A. Aebersold, L. Aven, D.Z. Wetmore, and S.K. Pal (2015). Scientific Reports 5, 13865, 1-17. PMID: 26353920. Is sham cTBS real cTBS? The effect on EEG dynamics. Opitz, A., W. Legon, J. Mueller, A. Barbour, W. Paulus, and W.J. Tyler (2015). Frontiers in Human Neuroscience 8, 1043. PMID: 25620925. Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics. Mueller, J., W. Legon, A. Opitz, T.F. Sato, W.J. Tyler (2014). Brain Stimulation 7(6), 900-908. PMID: 25265863. A quantitative overview of biophysical forces impinging on neural function. Mueller, J. and W.J. Tyler (2014). Physical Biology 11(5), 1-15. PMID: 25156965. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Legon, W., T.F. Sato, A. Opitz, J. Mueller, A. ...
Central sulcus - The groove (sulcus) on the brain that separates the primary somatosensory cortex (parietal lobe) from the primary motor cortex (frontal lobe).. ...
Study of the pyramidal cells and interneurons recruited by intracortical microstimulation in primary somatosensory cortex. Code includes morphological models for seven types of pyramidal cells and eight types of interneurons, NEURON code to simulate ICMS, and an artificial reconstruction of a 3D slab of cortex implemented in MATLAB ...
Global neurovascular devices market expected to generate around USD 2.89 billion by 2025, at a CAGR of around 5.4% between 2019 and 2025. Neurovascular devices are used to treat neurovascular diseases or disorders. Neurovascular diseases are caused when the blood vessels in the brain or spinal cord function abnormally.
Article: Synaptic properties of thalamic input to the subgranular layers of primary somatosensory and auditory cortices in the mouse. ...
Anatomical vessel network extracted from two-photon scans of a rodent somatosensory cortex. In this work, the authors develop a hybrid model to solve for the time-varying oxygen advection-diffusion equation in the vessels and tissue. [See - Q. Fang, S. Sakadzic, L. Ruvinskaya, et. al., Fig. 4 for details.]. ...
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Cortical excitability can be reliably assessed by means of paired-pulse stimulation techniques. Recent studies demonstrated particularly for motor and visual cortex that cortical excitability is systematically altered following the induction of learning processes or during the development of pathological symptoms. A recent tactile coactivation protocol developed by Godde and coworkers showed that improvement of tactile performance in humans can be achieved also without training through passive stimulation on a time scale of a few hours. Tactile coactivation evokes plastic changes in somatosensory cortical areas as measured by blood oxygenation level-dependent (BOLD) activation in fMRI or SEP-dipole localization, which correlated with the individual gain in performance. To demonstrate changes in excitability of somatosensory cortex after tactile coactivation, we combined assessment of tactile performance with recordings of paired-pulse SEPs after electrical median nerve stimulation of both the ...