We tested the hypothesis that HBV Pol recognizes the 5′ cap structure via its interaction with eIF4E. Here, we showed that HBV Pol directly interacts with eIF4E using coimmunoprecipitation (Fig. 2), which demonstrated that the eIF4E-Pol interaction is enhanced significantly by ε RNA, and implicating the formation of an eIF4E-Pol-ε ribonucleoprotein (RNP) complex prior to nucleocapsid assembly (Fig. 2). Further, we showed that eIF4E was incorporated into the nucleocapsid along with HBV Pol, indicating that the eIF4E interacts with the Pol-ε RNP complex during nucleocapsid assembly (Fig. 7). To our knowledge, it is unprecedented that a translation factor such as eIF4E is incorporated into viral nucleocapsid particles.. The pgRNA could enhance the HBV Pol-eIF4E interaction as a consequence of tethering, since both HBV Pol and eIF4E could bind to the pgRNA independently via their respective binding to epsilon and cap structure, respectively (Fig. 1). To preclude the tethering effect, we ...

Functional Overlap between eIF4G Isoforms in Saccharomyces cerevisiae. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Plant viruses recruit cellular translation factors not only to translate their viral RNAs but also to regulate their replication and potentiate their local and systemic movement. Because of the virus dependence on cellular translation factors, it is perhaps not surprising that many natural plant recessive resistance genes have been mapped to mutations of translation initiation factors eIF4E and eIF4G or their isoforms, eIFiso4E and eIFiso4G. The partial functional redundancy of these isoforms allows specific mutation or knock-down of one isoform to provide virus resistance without hindering the general health of the plant. New possible targets for antiviral strategies have also been identified following the characterization of other plant translation factors (eIF4A-like helicases, eIF3, eEF1A and eEF1B) that specifically interact with viral RNAs and proteins and regulate various aspects of the infection cycle. Emerging evidence that translation repression operates as an alternative antiviral RNA

The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well

References for Abcams Recombinant Human EIF1AY protein (ab103788). Please let us know if you have used this product in your publication

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Recombinant Eukaryotic Translation Initiation Factor 1 (EIF1) Protein (GST tag). Spezies: Human. Quelle: Escherichia coli (E. coli). Jetzt Produkt ABIN1046988 bestellen.

Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, BIOCHEMISTRY & MOLECULAR BIOLOGY, cap-independent protein synthesis, IRES, translation initiation factor elF4G, viral proteases, MOUTH-DISEASE VIRUS, CAP-INDEPENDENT TRANSLATION, 5 NONCODING REGION, HUMAN NEURO-BLASTOMA, INITIATION-FACTOR, POLIOVIRUS RNA, INVITRO TRANSLATION, LEADER PROTEIN, CLEAVAGE SITE, NEUROVIRULENT ...

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

BACKGROUND: P150, a 150 kDa protein, was isolated from virally and oncogene-transformed mouse cell lines, partially purified and cloned. P150 is part of the large subunit of the eukaryotic translation initiation factor 3 with sequence homology to cen

EIF3CL (eukaryotic translation initiation factor 3 subunit C like), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.

EIF3C (eukaryotic translation initiation factor 3, subunit C), Authors: Daniel R Scoles. Published in: Atlas Genet Cytogenet Oncol Haematol.

Ligand interactions with eukaryotic translation initiation factor 2: role of the gamma-subunit.: Eukaryotic translation initiation factor 2 (eIF-2) comprises th

Page contains details about 7-methylguanosine-capped green fluorescent protein mRNA/human eukaryotic initiation factor 4E@triethylene tetramine-substituted polyamine nanoplexes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through ...

Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated

eukaryotic translation initiation factor 2B family protein / eIF-2B family protein; FUNCTIONS IN: GTP binding, translation initiation factor activity; INVOLVED IN: translational initiation, cellular metabolic process; LOCATED IN: eukaryotic translation initiation factor 2B complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Initiation factor 2B related (InterPro:IPR000649); BEST Arabidopsis thaliana protein match is: GTP binding / translation initiation factor (TAIR:AT2G44070.1); Has 3102 Blast hits to 3086 proteins in 618 species: Archae - 219; Bacteria - 968; Metazoa - 478; Fungi - 332; Plants - 115; Viruses - 0; Other Eukaryotes - 990 (source: NCBI BLink ...

The present study demonstrated marked heterogeneity in the distribution of genotypes and alleles of the PP1 G subunit gene in Japanese and white subjects. The frequency of the Tyr/Tyr genotype or Tyr allele in the Danish population is so low that the Tyr allele is reported as a variant.18 In contrast, in the Japanese population, the Tyr allele was a major allele, and the Tyr/Tyr genotype frequency was as high as 50%. These data may reflect differences in the genetic backgrounds of the populations and indicate that this polymorphism is not a variant but a polymorphism whose distribution exhibits marked diversity between different ethnic groups. The large number of individuals homozygous for the Tyr allele in our population has allowed us to assess the functional alteration related to the Tyr allele in the homozygous form. Our data demonstrated that the Asp905Tyr polymorphism of the PP1 G subunit was not associated with essential hypertension itself or with insulin resistance in hypertensives. ...

Wiki-Pi: a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, genome-wide association studies (GWAS), GO enrichments, PDB ID, Uniprot ID, HPRD ID, and word cloud from pubmed abstracts.

Wiki-Pi: a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, genome-wide association studies (GWAS), GO enrichments, PDB ID, Uniprot ID, HPRD ID, and word cloud from pubmed abstracts.

Reaktivität: Arabidopsis thaliana, Human, Maus. verschiedene EIF1A Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!

Eukaryotic Translation Initiation Factor 3, Subunit D Antibody is a Rabbit Polyclonal antibody against Eukaryotic Translation Initiation Factor 3, Subunit D.

These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...

These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...

The original bug hits both openstack-puppet-modules and openstack-tripleo-heat-templates. Cloning this so that the openstack-puppet-modules part gets fixed +++ This bug was initially created as a clone of Bug #1252585 +++ Description of problem: Deployment fails on one of the controller nodes. The deployment is on 3 controllers, 5 computes, and 2 ceph nodes at the moment. The error that causes the stack to fail comes from puppet on Controller-0 Aug 11 11:24:29 localhost os-collect-config: ::Server[6000]): The default incoming_chmod set to 0644 may yield in error prone directories and will be changed in a later release.\u001b[0m\n\u001b[1;31mWarning: Scope(Swift::Storage::Server[6000]): The default outgoing_chmod set to 0644 may yield in error prone directories and will be changed in a later release.\u001b[0m\n\u001b[1;31mWarning: The package types allow_virtual parameter will be changing its default value from false to true in a future release. If you do not want to allow virtual packages, ...

The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in cancer, thus understanding how this protein leads to the selective re-programming of the translational landscape is critical. While it is known that eIF4A1-dependent mRNAs frequently have long GC-rich 5′UTRs, the details of how 5′UTR structure is resculptured by eIF4A1 to enhance the translation of specific mRNAs are unknown. Using Structure-seq2 and polysome profiling, we assess global mRNA structure and translational efficiency in MCF7 cells, with and without eIF4A inhibition with hippuristanol. We find that eIF4A inhibition does not lead to global increases in 5′UTR structure, but rather it leads to 5′UTR remodeling, with localized gains and losses of structure. The degree of these localized structural changes is associated with 5′UTR length, meaning that eIF4A-dependent mRNAs

Koesters R، Adams V، Betts D، Moos R، Schmid M، Siermann A، Hassam S، Weitz S، Lichter P، Heitz PU، von Knebel Doeberitz M، Briner J (Dec 1999). Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. Genomics. 61 (2): 210-8. PMID 10534406. doi:10.1006/geno.1999.5951. الوسيط ...

EIF4EBP1 - EIF4EBP1 (untagged)-Human eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) available for purchase from OriGene - Your Gene Company.

Complete information for EIF3M gene (Protein Coding), Eukaryotic Translation Initiation Factor 3 Subunit M, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

EIF3E - EIF3E (untagged)-Human eukaryotic translation initiation factor 3, subunit E (EIF3E) available for purchase from OriGene - Your Gene Company.

4E-BP1 (phospho Thr37/Thr46) antibody (eukaryotic translation initiation factor 4E binding protein 1) for WB. Anti-4E-BP1 (phospho Thr37/Thr46) pAb (GTX133181) is tested in Human samples. 100% Ab-Assurance.

4E-BP1 (phospho Thr37/Thr46) antibody (eukaryotic translation initiation factor 4E binding protein 1) for WB. Anti-4E-BP1 (phospho Thr37/Thr46) pAb (GTX133182) is tested in Human samples. 100% Ab-Assurance.

Translation Initiation Factor EIF5B; GTPase That Promotes Met-tRNAiMet Binding To Ribosomes And Ribosomal Subunit Joining; Promotes GTP-dependent Maturation Of 18S RRNA By Nob1p; Protein Abundance Increases In Response To DNA Replication Stress; Homolog Of Bacterial IF2

OConnor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis ...

PMID 11835386] Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. ...

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Buy our Recombinant Human EIF3F protein. Ab152904 is a full length protein produced in Wheat germ and has been validated in WB, ELISA. Abcam provides free…

Looking for online definition of eukaryotic translation initiation factor 1A, X chromosome1 in the Medical Dictionary? eukaryotic translation initiation factor 1A, X chromosome1 explanation free. What is eukaryotic translation initiation factor 1A, X chromosome1? Meaning of eukaryotic translation initiation factor 1A, X chromosome1 medical term. What does eukaryotic translation initiation factor 1A, X chromosome1 mean?

cytoplasm, eukaryotic translation initiation factor 4F complex, nucleus, polysome, postsynapse, ATP binding, eukaryotic initiation factor 4E binding, identical protein binding, mRNA binding, translation factor activity, RNA binding

The eukaryotic cap-binding complex eIF4F is an essential component of the translational machinery. Recognition of the mRNA cap structure through its subunit eIF4E is a requirement for the recruitment of other translation initiation factors to the mRNA 5-end and thereby for the attachment of the 40 S ribosomal subunit. In this study, we have investigated the mechanistic basis of the observation that eIF4E binding to the cap is enhanced in the presence of the large eIF4F subunit, eIF4G. We show that eIF4E requires access to both the mRNA 5-cap and eIF4G to form stable complexes with short RNAs. This stabilization can be achieved using fragments of eIF4G that contain the eIF4E binding site but not the RNA recognition motifs. Full-length eIF4G is shown to induce increased eIF4E binding to cap analogues that do not contain an RNA body. Both results show that interaction of eIF4G with the mRNA is not necessary to enhance cap binding by eIF4E. Moreover, we show that the effect of binding of ...

The IUPHAR/BPS Guide to Pharmacology. eukaryotic translation initiation factor 2 alpha kinase 1 - Other PEK family kinases. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.

Inappropriate surface expression of voltage-gated Ca(2+)channels (CaV) in pancreatic ß-cells may contribute to the development of type 2 diabetes. First, failure to increase intracellular Ca(2+) concentrations at the sites of exocytosis impedes insulin release. Furthermore, excessive Ca(2+) influx may trigger cytotoxic effects. The regulation of surface expression of CaV channels in the pancreatic β-cells remains unknown. Here, we used real-time 3D confocal and TIRFM imaging, immunocytochemistry, cellular fractionation, immunoprecipitation and electrophysiology to study trafficking of L-type CaV1.2 channels upon β-cell stimulation. We found decreased surface expression of CaV1.2 and a corresponding reduction in L-type whole-cell Ca(2+) currents in insulin-secreting INS-1 832/13 cells upon protracted (15-30 min) stimulation. This internalization occurs by clathrin-dependent endocytosis and could be prevented by microtubule or dynamin inhibitors. eIF3e (Eukaryotic translation initiation factor ...

The role of plant eIF5A proteins in multiple biological processes, such as protein synthesis regulation, translation elongation, mRNA turnover, programmed cell death and stress tolerance is well known

Eukaryotic translation initiation factor 3 subunit E (eIF3e) (C Terminus) antibody | P60228 | Eukaryotic translation initiation factor 3 subunit 6, Viral integration site protein INT-6 homolog, eIF-3 p48, EIF3S6, INT6

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

4E Binding Protein phosphorylated 4EBP1 4E Protein Synthesis Initiation Factor Binding Protein eIF PHAS 1 PHAS I Eukaryotic Translation Initiation F|gentaur.com

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The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, and gamma subunits, or Gα, Gβ, and Gγ. When a G protein-coupled receptor (GPCR) is activated, Gα dissociates from Gβγ, allowing both subunits to perform their respective downstream signaling effects. One of the major functions of Gβγ is the inhibition of the Gα subunit. The individual subunits of the G protein complex were first identified in 1980 when the regulatory component of adenylate cyclase was successfully purified, yielding three polypeptides of different molecular weights. Initially, it was thought that Gα, the largest subunit, was the major effector regulatory subunit, and that Gβγ was largely responsible for inactivating the Gα subunit and enhancing membrane binding. However, ...

Herewith, we report development of small molecule inhibitors of MNK1 and MNK2 kinases and their cellular activity. MNK1 and 2 are MAP kinase-interacting kinases are activated by RAS and MAPK signaling pathways, and are involved in regulation of translation. Both kinases phosphorylate translation initiation factor eIF4e on a conserved serine 209. eIF4E can contribute to the oncogenic transformation both in vitro and in vivo and is highly expressed in diverse types of cancer. Interestingly, mice that lack both Mnk1 and Mnk2 do not have any apparent phenotype. Recently first dual MNK1/MNK2 inhibitors have entered clinical trials as a combinational therapy with docetaxel in NSCLC.. SEL201 is a series of small molecule inhibitors which inhibit activity of both MNK1 and MNK2 in a low nM range and high selectivity confirmed in kinome panels. Analysis of SEL201 cellular activity indicated potent inhibition of eIF4e Ser209 in vitro in cancer cells and in vivo after oral administration in xenograft ...

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van Gorp AG, van der Vos KE, Brenkman AB, Bremer A, van den Broek N, Zwartkruis F, Hershey JW, Burgering BM, Calkhoven CF, Coffer PJ. (2008) AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B. Oncogene.. Back to previous page ...

Detailed annotation info for 1396.m04152; PF14_0104 PF14_0104 eukaryotic translation initiation factor 2 gamma subunit, putative ...

Activated cap-dependent translation promotes cancer by stimulating translation of mRNAs encoding malignancy-promoting proteins. The nucleoside monophosphat

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G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.