An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together during RNA splicing. The EJC has major influences on translation, surveillance and localization of the spliced mRNA. It is first deposited onto mRNA during splicing and is then transported into the cytoplasm. There it plays a major role in post-transcriptional regulation of mRNA. It is believed that exon junction complexes provide a position-specific memory of the splicing event. The EJC consists of a stable heterotetramer core, which serves as a binding platform for other factors necessary for the mRNA pathway. The core of the EJC contains the protein eukaryotic initiation factor 4A-III (eIF4A-III; a DEAD-box RNA helicase) bound to an adenosine triphosphate (ATP) analog, as well as the additional proteins Magoh and Y14.The binding of these proteins to nuclear speckled domains has been measured recently and it may be regulated by PI3K/AKT/mTOR ...
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in cancer, thus understanding how this protein leads to the selective re-programming of the translational landscape is critical. While it is known that eIF4A1-dependent mRNAs frequently have long GC-rich 5′UTRs, the details of how 5′UTR structure is resculptured by eIF4A1 to enhance the translation of specific mRNAs are unknown. Using Structure-seq2 and polysome profiling, we assess global mRNA structure and translational efficiency in MCF7 cells, with and without eIF4A inhibition with hippuristanol. We find that eIF4A inhibition does not lead to global increases in 5′UTR structure, but rather it leads to 5′UTR remodeling, with localized gains and losses of structure. The degree of these localized structural changes is associated with 5′UTR length, meaning that eIF4A-dependent mRNAs
ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A
Complete information for MAGOHB gene (Protein Coding), Mago Homolog B, Exon Junction Complex Core Component, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The exon junction complex regulates the cell polarity determinant Discs large 1, which acts independently from its role in cell polarity to protect Dishevelled protein from lysosomal degradation in Wingless/Wnt signaling.
Detection of exon junctions in single cells within the tissue environment is possible by using only one ZZ probe uniquely designed on the specific exon junction of interest. For an example of the detection of a sequence with specific exon skipping, METΔ14 (Frampton GM et al, Cancer Discovery, 2015; Awad MM et al, J Clin Oncol, 2016) where 3 probes are designed (image 1): one control probe designed for an exon junction present in all MET transcripts (exon junction 12/13), one probe designed for the exon junction with exon 14 (exon junction 14/15), and one probe designed for the exon junction with exon 14 skipping (exon junction 13/15). Figure 2 shows an example of the BaseScope™ assay used for the detection of METΔ14 in cell lines ...
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Translational control is primarily exerted at the initiation phase, a complex process mediated by a number of eucaryotic translation initiation factors (eIFs), during which ribosomes are recruited to the 5′ end of an mRNA and positioned at a start codon (reviewed in Gingras et al, 1999b; Hershey and Merrick, 2000). The mRNA 5′ end is distinguished by the presence of a cap structure (m7GpppN, where m is a methyl group and N is any nucleotide), which is specifically bound by the cap‐binding protein eIF4E. eIF4E, via an interaction with the large scaffolding protein eIF4G, guides the translation machinery to the 5′ end of mRNA. eIF4E and eIF4G function as components of the dynamic, heterotrimeric eIF4F complex, along with the DEAD box RNA helicase eIF4A. Optimal ribosome binding is thought to require a region of single‐stranded mRNA (Gingras et al, 1999b). Thus, it has been proposed that one critical function of eIF4F is to melt cap‐proximal inhibitory secondary structure to provide a ...
Smg-4/UPF3-like protein; Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the production of nons [...] (484 aa ...
Smg-4/UPF3-like protein; Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the production of nons [...] (484 aa ...
References for Abcams Recombinant Human EIF1AY protein (ab103788). Please let us know if you have used this product in your publication
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Eukaryotic translation initiation factor 4A (eIF4A) is a DEAD-box protein that participates in translation initiation. As an ATP-dependent RNA helicase, it is thought to resolve secondary structure elements from the 5-untranslated region of mRNAs to enable ribosome scanning. The RNA-stimulated ATPa …
WB] - Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S., Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay, Genes Dev. [Pubmed: 16452507] ...
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RNA helicases are vital components of various pathways for post-transcriptional gene regulation. TgHoDI is a newly identified member of the DEAD-box RNA helicase family in Toxoplasma gondii. This study was aimed at characterizing the function of TgHoDI in post-transcriptional regulation during various stages of the parasite life cycle. Through immunofluorescence analyses, TgHoDI was found to colocalize with mRNA aggregates in cytoplasmic foci. Furthermore, colocalization studies of TgHoDI with PABPC3 identified these proteins as components of RNA aggregates known as stress granules. Cycloheximide and arsenite treatment of extracellular parasites revealed the presence of mechanisms involved in the determination of mRNA fate in Toxoplasma. Also, TgHoDI was found to functionally compliment the temperature sensitive phenotype in Δdhh1 yeast, validating its role in stress response. These findings confirm that TgHoDI is a vital component in the formation of stress granules and possibly involved in the
Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5UTRs; these functions seem to require RNA helicase activity. ...
DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3 to 5 RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.
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Protein CASC3 is a protein that in humans is encoded by the CASC3 gene. The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. GRCh38: Ensembl release 89: ENSG00000108349 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000078676 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367-76. doi:10.1006/geno.1995.1163. PMID 7490069. Arriola E, Marchio C, Tan DS, ...
Knowledge of the balance of activities of eukaryotic initiation factors (eIFs) is critical to our understanding of the mechanisms underlying translational control. We have therefore estimated the intracellular levels of 11 eIFs in logarithmically growing cells of Saccharomyces cerevisiae using polyclonal antibodies raised in rabbits against recombinant proteins. Those factors involved in 43S complex formation occur at levels comparable (i.e. within a 0.5- to 2.0-fold range) to those published for ribosomes. In contrast, the subunits of the cap-binding complex eIF4F showed considerable variation in their abundance. The helicase eIF4A was the most abundant eIF of the yeast cell, followed by eIF4E at multiple copies per ribosome, and eIF4B at approximately one copy per ribosome. The adaptor protein eIF4G was the least abundant of the eIF4 factors, with a copy number per cell that is substoichiometric to the ribosome and similar to the abundance of mRNA. The observed excess of eIF4E over its ...
ATP-dependent RNA helicase p54, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD), DEAD box protein 6, EC 3.6.4.13, EC 3.6.1, FLJ36338, HLR2DEAD box-6, Oncogene RCK, probable ATP-dependent RNA helicase DDX6, ...
Complete information for DDX17 gene (Protein Coding), DEAD-Box Helicase 17, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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The recessive nuclear vdl (for variegated and distorted leaf) mutant of tobacco was obtained by T-DNA insertion and characterized by variegated leaves and abnormal roots and flowers. Affected leaf tissues were white and distorted, lacked palisadic cells, and contained undifferentiated plastids. The variegation was due to phenotypic, rather than genetic, instability. Genomic and cDNA clones were obtained for both the mutant and wild-type VDL alleles. Three transcripts, resulting from alternate intron splicing or polyadenylation, were found for the wild type. The transcripts potentially encode a set of proteins (53, 19, and 15 kD) sharing the same N-terminal region that contains a chloroplast transit peptide capable of importing the green fluorescent protein into chloroplasts. The predicted 53-kD product belongs to the DEAD box RNA helicase family. In the homozygous vdl mutant, T-DNA insertion resulted in accumulation of the shortest transcript and the absence of the RNA helicase-encoding ...
We have previously demonstrated that the DEAD-box RNA helicase p68 is an important regulator of gene expression [1, 2], whilst other groups have shown that p68 interacts with and coactivates estrogen receptor alpha (ERα) [3, 4]. The main focus of our project is to investigate the molecular mechanism of ERα coactivation by p68 and to examine the potential consequences for breast cancer development.. We have established that the interaction of p68 and ERα requires the DNA binding domain of ERα and the C terminus of p68. Importantly, this region of p68 lies outside the conserved helicase core and was previously shown by us to be essential for transcriptional regulation by p68. Additionally, coactivation of ERα by p68 requires the ligand binding/AF2 region of ERα and is consistent with the model that p68 is recruited to ERα-responsive promoters in response to estrogen [4]. We have also shown that p72, a helicase that is very highly related to p68 and that had previously been suggested to act ...
Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC). The role of the Y14 C-terminal serine/arginine (RS) repeat-containing region, which has been reported to undergo modifications such as phosphorylation and methylation, has not been sufficiently investigated. Thus, we aimed to explore the functional significance of the Y14 C-terminal region. Deletion or dephosphorylation mimic mutants of the C-terminal region showed a shift in localization from the nucleoplasmic region; in addition, the C-terminal RS repeat-containing sequence itself exhibited the potential for nucleolar localization ...
In this study, the Ephrussi lab shows that an atypical tropomyosin isoform is a direct (m)RNA binding protein that binds preferentially to the dimerizing oskar 3 UTR and is a component of the transported oskar mRNPs within the female germ-line. In the absence of this tropomyosin isoform, Khc fails to get loaded onto oskar mRNA, which explains the reduced motility and ultimately the failure in oskar localization. This Tm1-I/C dependent recruitment is rather inefficient - only a small fraction of oskar mRNPs acquire Khc - but dynamic, enabling the posterior-ward transport of virtually all oskar mRNPs. Most importantly, however, the Tm1-I/C recruited Khc is inactive. Activation of the motor only commences in the oocyte during mid-oogenesis - possibly to prevent interference with the other transporter of oskar, cytoplasmic dynein - and requires the previously identified exon junction complex (EJC) and associated spliced oskar localization element (SOLE).. Gaspar, I., Sysoev, V., Komissarov, A. and ...
CP000675.RHLE Location/Qualifiers FT CDS complement(351367..352611) FT /codon_start=1 FT /transl_table=11 FT /gene="rhlE" FT /locus_tag="LPC_0327" FT /product="ATP-dependent RNA helicase, DEAD box family" FT /db_xref="EnsemblGenomes-Gn:LPC_0327" FT /db_xref="EnsemblGenomes-Tr:ABQ54322" FT /protein_id="ABQ54322.1" FT /translation="MSFKQLALIEPLNRAVSELGYTNPTSIQLKAIPLILNGHDLLGSA FT QTGTGKTASFVLPILQKASQQTQTSRNRVKVLILTPTRELAIQVHESIIQYGKYLTLRS FT AVIYGGVKSHNQIKQLDSGLEILVATPGRLLDLYQQGAVKFDEIDTLVLDEADRMLDMG FT FIHDIKKIIKLLPLKRQNLLFSATFTPEVRTLARNILNKAVEIDIAPRNTAVKTIKQTV FT YSVDRNHKLALLSHLLHKNNWGQTLVFSRTKHGANKLVKQLAESQIYSVAIHGNKSQAQ FT RTKALADFKSGKVQTLIATDIAARGIDIEKLACVVNFDLPHVPEDYVHRIGRTGRAGAS FT GLAVSLVSTEEIKLLLSIEKLINQKLERIKIKDFEFLHNFSDLVSAKIQKFAPPKAGYK FT GNISRKSRTAFNKSA" MSFKQLALIE PLNRAVSELG YTNPTSIQLK AIPLILNGHD LLGSAQTGTG KTASFVLPIL 60 QKASQQTQTS RNRVKVLILT PTRELAIQVH ESIIQYGKYL TLRSAVIYGG VKSHNQIKQL 120 DSGLEILVAT PGRLLDLYQQ GAVKFDEIDT LVLDEADRML DMGFIHDIKK IIKLLPLKRQ 180 NLLFSATFTP EVRTLARNIL ...
The putative ATP-dependent RNA helicase LGP2 is encoded by the DHX58 gene in humans. LGP2 is also known as DEXH (Asp-Glu-X-His) box polypeptide 58; probable ATP-dependent RNA helicase DHX58, DHX58, protein D11Lgp2 homolog, RIG-I-like receptor LGP2, RLR, RLR3, D11LGP2, and D11LGP2E. LGP2 was first identified in mammary tissue, but its function was subsequently found to be more relevant in innate antiviral immunity. It is essential for producing effective antiviral responses against many viruses that are recognized by the receptors DDX58/RIG-I and IFIH1/MDA5. This role of LGP2, which can have both positive and negative regulatory effects, is complex and depends on the characteristics of the infecting virus and the target cells. It is suggested that its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA, thereby facilitating their recognition by viral receptors. LGP2 binds to ds RNA with high affinity, but it can also bind ss RNA.. ...
The putative ATP-dependent RNA helicase LGP2 is encoded by the DHX58 gene in humans. LGP2 is also known as DEXH (Asp-Glu-X-His) box polypeptide 58; probable ATP-dependent RNA helicase DHX58, DHX58, protein D11Lgp2 homolog, RIG-I-like receptor LGP2, RLR, RLR3, D11LGP2, and D11LGP2E. LGP2 was first identified in mammary tissue, but its function was subsequently found to be more relevant in innate antiviral immunity. It is essential for producing effective antiviral responses against many viruses that are recognized by the receptors DDX58/RIG-I and IFIH1/MDA5. This role of LGP2, which can have both positive and negative regulatory effects, is complex and depends on the characteristics of the infecting virus and the target cells. It is suggested that its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA, thereby facilitating their recognition by viral receptors. LGP2 binds to ds RNA with high affinity, but it can also bind ss RNA.. ...
Helicases have been classified in 5 superfamilies (SF1-SF5). For the two largest groups, commonly referred to as SF1 and SF2, a total of seven characteristic motifs has been identified [(PUBMED:2546125)]. These two superfamilies encompass a large number of DNA and RNA helicases from archaea, eubacteria, eukaryotes and viruses.. This entry represents the C-terminal domain found in proteins belonging to the helicase superfamilies 1 and 2. Included in this group is the eukaryotic translation initiation factor 4A (eIF4A), a member of the DEA(D/H)-box RNA helicase family. The structure of the carboxyl-terminal domain of eIF4A has been determined; it has a parallel alpha-beta topology that superimposes, with minor variations, on the structures and conserved motifs of the equivalent domain in other, distantly related helicases [(PUBMED:11087862)].. ...
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked (DDX3X) is a gene that encodes a protein that belongs to the large DEAD-box protein family. The protein functions in the in the nucleus and the cytoplasm of the cell and exhibits ATP-dependent RNA helicase activity and RNA-independent ATPase activity. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.. DDX3X is altered in 0.14% of all cancers. The most common alterations in DDX3X are DDX3X D506G (0.00%) and DDX3X Mutation (0.00%) [3]. ...
Mao, H, Brown, H, and Silver, DL. Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. RNA. Online Oct. 25. pii: rna.058826.116. PMID: 27780844.. Pilaz, LJ*, McMahon, JJ*, Miller, EE, Lennox, AL, Suzuki, A, Salmon, E, Silver, DL, Prolonged mitosis of neural progenitors alters cell fate in the developing brain. Jan 6; 89(1):83-99. 2016. *co-first authors.. Mao, H, Pilaz, LJ, McMahon, J, Golzio, C, Wu, D, Shi, L, Katsanis, N, and Silver, DL Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly. Journal of Neuroscience. May 6; 35(18): 7003-7018. (Featured on cover and in News and Views in same issue). Boyd, JL, Skove, SL, Rouanet, JP, Pilaz, L-J, Bepler, T, Gordân, R, Wray, GA, and Silver, DL. Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex. Current Biology. Mar 16; 25 (6) 772-9. 2015. (Featured in over 75 online and print forums including Science, ...
Background Probable ATP-dependent RNA helicase. Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed23019224). Description DDX31 Polyclonal Antibody, Biotin Conjugated. Biotin....
human EIF3D gene cDNA, cloning vector & expression plasmid, mutiple tags. Optimized for high expression in mammalian cells. Save up to 60%.
1810016I04Rik,2700079K05Rik,AA409117,AA409446,C78575,Eif3j,Eif3j-1,Eif3j-2,Eif3j2,Eif3s1,eIF-3-alpha-A,eIF-3-alpha-B,eIF3-alpha,eIF3-p35,eIF3j-A,eIF3j- ...
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eIF3H / EIF3S3 antibody [N2C3] (eukaryotic translation initiation factor 3, subunit H) for WB. Anti-eIF3H / EIF3S3 pAb (GTX106886) is tested in Human samples. 100% Ab-Assurance.
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酵母细胞通过提高葡萄糖合成酶和糖酵解作用维持能量代谢的平衡。在人体细胞中我们也发现了同样的代谢调节途径,主要通过eIF3e蛋白与代谢相关的mRNA结合并促进这些与能量代谢相关的蛋白表达来维持代谢的平衡。在肿瘤形成的过程中,这种通过eIF3d和eIF3e调控的能量代谢机制是被打破的,因此该研究成果将有助于科学家通过靶向代谢通路研发治愈肿瘤的药物。该研究利用转录组学、蛋白组学和代谢组学的方法发现缺少了eIF3e和eIF3d的裂殖酵母细胞无法合成线粒体电子传递链相关的蛋白,从而导致呼吸功能阻断,内源性的氧化应激压力和细胞老化产生。 课题组硕士研究生苏丹为共同第一作者 。 Dieter A. ...
2007 (Swedish)In: Nordisk försäkringstidskrift, ISSN 0348-6516, no 1, 76-84 p.Article in journal (Other academic) Published ...
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... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
BACKGROUND: P150, a 150 kDa protein, was isolated from virally and oncogene-transformed mouse cell lines, partially purified and cloned. P150 is part of the large subunit of the eukaryotic translation initiation factor 3 with sequence homology to cen
These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...