Brief exposure early in life to endocrine disrupting chemicals, especially those with estrogenic activity like DES, increases bodyweight as the mice age.
Prenatal exposure to the synthetic estrogen diethylstilbestrol (DES) causes morphogenetic alterations and neoplasia in the human reproductive tract. In the hamster, neonatal DES exposure alters early uterine morphogenesis and induces endometrial adenocarcinomas in adults. We now demonstrate that the preneoplastic stages of this phenomenon in the hamster reflect an abnormal uterotropic response to estrogen that is characterized by hyperplastic lesions in the endometrial epithelium and includes an immune and/or inflammatory component. Interestingly, biochemical and in situ analysis revealed that the hyperplastic epithelium is also an active site of cell death by apoptosis. To further probe the mechanism of this phenomenon, uteri from 7-day-old control or DES-exposed donors were transplanted into the cheek pouches of control or neonatally DES-exposed adult hosts, and both host groups were treated to provide high circulating levels of estradiol. Among the four ectopic scenarios, histopathological ...
The effects of neonatal diethylstilbestrol (DES) exposure on the morphology and proliferating patterns of endometrial epithelial cells were investigated at various stages of development in mice. Female CD-1 mice were given daily subcutaneous injectio
This project screened for altered expression of small RNA species, microRNAs (miRNA), in the hamster uterus following neonatal exposure to the potent synthetic estrogen and established endocrine disruptor diethylstilbestrol (DES). Neonatal DES exposure results in a dysplastic/neoplastic response of the adult hamster uterus to the natural ovarian estrogen, estradiol (E2). In the present study, miRNA profiling was performed with total RNA extracted from the uteri of control and neonatally DES-treated female hamsters. We exploited a highly sensitive, reliable, and accurate microarray profiling technology and used it to screen for the differential expression of miRNA genes during both the initiation and promotion stages of estrogen-dependent endometrial adenocarcinoma in the neonatally DES-treated hamster. MiRNAs that were two-fold or more differentially expressed in DES-treated animals compared with the control animals were validated using a sensitive and highly specific quantitative RT-PCR ...
Diethylstilbestrol (DES) is a synthetic compound and considered as an endocrine disruptor that interferes with the normal development of human organs and even immune tissues. DES has been investigated for its immunosuppressive effects, thymic atrophy, and various types of cancer including breast cancer, ovarian cancer, uterine cancer, etc. In this study, we investigated DES regulated mechanisms in T cells and examined whether DES exposure of T cells leads immune suppression and affects immune functions. To this end, we investigated the effect of DES on T cells in vitro and specifically examined DES-induced apoptosis in T cells, expression of genes involved in apoptosis, and differentiation of T helper cells in vitro. We observed significant increase in apoptosis in activated T cells in dose-dependent manner in vitro. Upon examination of FasL expression in activated T cells, there was a significant increase in FasL expression in activated T cells post DES treatment. Furthermore, upon examination of
What kinds of research are still going on? Researchers continue to monitor the health status of 15,000 members of the combined cohort study. Many of the health problems being monitored are health problems that may be influenced by exposure to DES before birth (in the womb). These health problems include breast cancer in women, testicular cancer in men, and the potential interaction of hormone replacement therapy with DES exposure.. Researchers also are monitoring rates of health problems that appear to have no relationship to DES exposure (such as heart disease and diabetes). Scientists have no hypothetical or other reason to believe there is any link between DES and these diseases. These studies are being done to evaluate the overall health of DES-exposed persons.. Why dont we have final answers about DES health risks? The health risks associated with DES exposure change over a persons lifetime. Consequently, research is ongoing to learn how health risks change as DES-exposed persons ...
Although it is well established that women exposed to diethylstilbestrol in utero have an increased risk of spontaneous abortion, ectopic pregnancy, and preterm delivery, it is not known whether they also have an increased risk of infertility. The authors assessed this question in data from a collaborative follow-up study of the offspring of women who took diethylstilbestrol during pregnancy.. In 1994, 1,753 diethylstilbestrol-exposed and 1,050 unexposed women from an ongoing cohort study (National Cooperative Diethylstilbestrol Adenosis Study and Dieckmann cohorts) provided data on difficulties in conceiving and reasons for the difficulty. Age-adjusted relative risks were computed for the association of diethylstilbestrol exposure with specific types of infertility.. ...
This issue of my Ezine will discuss the negative effects of xenoestrogen and excess estrogen hormone levels and the formation of ovarian cysts. Many women experience the formation of functional cysts on their ovaries that causes infertility, abnormal ovary, decreased ovulation and PCOS. All these conditions have a common cause: xenostrogen compounds found in your water, in your food and in your environment. When xenostrogen find their way into your body the cause a condition called estrogen dominance, where the hormonal levels of estrogen are so elevated that progesterone levels become so low that ovulation is delayed or impaired. Ovarian cysts form when ovulation does not occur due to poor progesterone production or PCOS and the follicle continues to growth. The development and growth of ovarian cysts is most likely related xenoestrogens. Find more information on natural ovarian cysts treatment. What Are Xenoestrogen? Xenoestrogen are chemical compounds that mimic the action or natural estrogen ...
DES was the first synthetic estrogen and was given to pregnant women from 1938-1971 to prevent miscarriages. It was found to cause health issues for the women who took DES and for the children born of these pregnancies (called DES daughters, DES sons).
For ,20 years, research in our laboratory has focused on the effects of estrogenic compounds on development and differentiation. Our working premise has been that the developing organism is extremely sensitive to perturbation by chemicals with estrogenic or endocrine disrupting activity and that exposure to these chemicals during critical stages of differentiation may have permanent long-lasting consequences, some of which may not be expressed or detected until later in life. Diethylstilbestrol (DES) is a well-known example of such a chemical; thus, we have used DES as a model chemical to study environmental estrogens.. DES, a synthetic estrogen, was widely prescribed from the 1940s through the 1970s for the prevention of threatened miscarriage. A range of 2-8 million treated pregnancies worldwide has been estimated. Today it is well recognized that prenatal DES treatment results in a low incidence of neoplasia in the female offspring and a high incidence of benign abnormalities in both the male ...
Learn more about the Centers findings on bisphenol-A (BPA) and what you can do to limit your exposure to this harmful chemical.
BPA, Your Teeth, & Radius Toothbrush There are toxins and pollutants that you try to avoid every single day, but some of these toxins can be almost impossible to dodge. Bisphenol-A, or BPA, is one chemical that you most likely come in contact with multiple times every day. It taints the plastics that you use … *. *Results May VaryContinue reading. ...
Health,... LONDON May 15 /- ...- Health Professionals Calling for Further Guidance From Department of...Whilst a controversial chemical found in most plastic baby bottles has...BPA is a man-made oestrogen used in most hard transparent bottles top...,Bounty,Poll,Reveals,British,Mums,in,the,Dark,Over,Bisphenol-A,in,Baby,Bottles,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
BISPHENOL-A (BPA)는 페놀 2mole과 아세톤 1mole과의 산성 이온교환수지 하에서 축합 반응에 의하여 생성되는 백색의 결정체로서 폴리카보네이트 수지, 에폭시 수지, 플라스틱 강화제 원료로 이용되고 있으며, 한 분자의 말단에 반응성이 우수한 두 개의 hydroxyl group을 가지고 있어, 분자량이 큰 고분자 화합물의 원료로 사용합니다. ...
10.10.2019 - Early childhood life in the womb is particularly sensitive to the effects of environmental pollutants. A team from Empa and the University of Vienna has now for the first time been able to show how a pollutant from contaminated food - the environmental estrogen zearalenone - spreads in the womb and is metabolized into harmful metabolites.
The synthetic estrogen diethylstilbestrol (DES) was widely prescribed in the 1940s, 50s, and 60s to prevent miscarriage and premature delivery. Its…
The teratogenic effects of diethylstilbestrol have continued to exact a heavy toll throughout the lifetime of women who were exposed to the drug in utero, investigators reported.
Bisphenol A BPA Definition - Bisphenol A (BPA), is a chemical found in clear plastics. Medical research has determined that exposure to BPA has a direct...
Bisphenol A is an endocrine disrupting chemicals that can give someone with mild PMS a really bad case of PMS. When toxicity of Bisphenol A builds in the body, hormones throughout the body are effected.
86 per cent of teenagers have traces of Bisphenol A (BPA), a chemical compound used to make plastics, in their body, an Engaged Research public engagement project in collaboration with the University of Exeter has found.
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Originally Posted by Family_guy This made me think of something interesting. So to play the devils advocate here dont you think there are other
Exposure to bisphenol A may reduce the effectiveness of chemotherapy treatments by inducing a group of proteins that protect cancer cells from the toxic effects of chemotherapy.
Bisphenol a diacetate. CAS Number: 10192-62-8. Catalog Number: AA0005VW. MDL Number: MFCD00026194. Molecular Formula: C19H20O4. Molecular Weight: 312.3597. AA Blocks.
[169 Pages Report] Check for Discount on 2017-2022 Global Top Countries Hydrogenated Bisphenol A Market Report report by LP Information INC. ...
Testing of your own hormones usually does not help clinically because many of the cosmetics and toiletries contain various chemicals and herbs that are estrogenic (xenoestrogens). These xenoestrogens do NOT show up on the hormone test.
Mounting evidence against a chemical we are exposed to daily is being ignored. What more do regulators need, ask David Melzer and Tamara Galloway
Looking for online definition of DES Exposure in the Medical Dictionary? DES Exposure explanation free. What is DES Exposure? Meaning of DES Exposure medical term. What does DES Exposure mean?
The effects of neonatal diethylstilbestrol (DES) exposure on the volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus (SDN-POA) and on GnRH-stimulated LH secretion were investigated in castrated female rats of known anogenital distance (AGD) at birth. The AGD was measured in females on the day of birth, and 0.1 microgram DES or corn oil was injected from Days 1 through 10 of life. The volume of the SDN-POA was significantly larger in animals that had received DES than in those that had received corn oil.
Potential trans-generational influence of diethylstilbestrol (DES) exposure emerged with reports of effects in grandchildren of DES-treated pregnant women and of reproductive tract tumors in offspring of mice exposed in utero to DES. Accordingly, we examined the trans-generational influence of DES on development of external genitalia (ExG) and compared effects of in utero DES exposure in CD-1 and C57BL/6 mice injected with oil or DES every other day from gestational days 12 to 18.Mice were examined at birth, and on 5-120 days postnatal to evaluate ExG malformations.. Of 23 adult (,60 days) prenatally DES-exposed males, features indicative of urethral meatal hypospadias ranged from 18% to 100% in prenatally DES-exposed CD-1 males and 31% to 100% in prenatally DES-exposed C57BL/6 males. Thus, the strains differed only slightly in the incidence of male urethral hypospadias. Ninety-one percent of DES-exposed CD-1 females and 100% of DES-exposed C57BL/6 females had urethral-vaginal fistula. All ...
NIEHS Grant P30ES000002. A study, supported in part by the NIEHS, identified medical devices as a potential source of exposure to bisphenol A (BPA) among premature infants in neonatal intensive care units. BPA is used to manufacture polycarbonate plastics, which are used in medical devices such as intravenous administration sets, syringes, and catheters. The researchers looked at the urinary BPA concentration for 55 infants and categorized each infants medical device use as low or high based on the number and invasiveness of devices. They found that the median urinary total BPA concentration of infants who had required four or more medical devices for three previous days was significantly higher, 36.6 micrograms per liter (µg/l), than for the infants requiring three or less devices, who had a BPA concentration of 13.9 µg/l. The researchers also collected and analyzed breast milk or formula samples, and found that the increased BPA concentration was not associated with the infants nutritional ...
Introduction: Octylphenol (OP) is a degradation product of alkylphenol ethoxylates that are widely used to in rubber, pesticides and paints. Bisphenol A (BPA) is an organic compound with two functional phenol groups and used to make polycarbonate plastic and epoxy resins, along with other applications. OP and BPA are known as endocrine disruptors that can induce inappropriate estrogenic action, and may disturb natural calcium metabolism. In the present study, the effects of OP and BPA on the calcium levels of serum and urine, and calcium transport genes were investigated in the duodenum, kidney and placenta of the pregnant mice.. Methods: From 6.5 to 16.5 days after post coitus (dpc), pregnant mice were orally given with ethylestradiol (EE, 0.2 mg/kg/day), OP (15, 45, or 135 mg/kg/day) or BPA (5 or 50 mg/kg/day) dissolved in corn oil. The duodenum, kidney, placenta, blood and urine were obtained from mice at day 18.5 of pregnancy.. Results: As a result, serum and urinary calcium levels were ...
If youre going through fertility treatments you may want to limit your BPA exposure. A Harvard study links BPA exposure to lower IVF success rates.
In the current study, all infants had detectable urinary concentrations of total BPA, ranging from 2.0 to 196 µg/L. The median urinary BPA concentration in this group of premature infants was considerably higher (17.2 μg/L) than in healthy term infants aged 1 to 5 months (,0.45 μg/L) without known BPA exposure.21 Although immaturity of phase II metabolism may account for some of the association of urinary BPA concentrations with prematurity, premature infants have the ability to conjugate BPA.16 Interestingly, medical devices, but not nutritional intake, were positively associated with urinary BPA concentrations. On average, premature infants requiring ≥4 medical devices had urinary total BPA concentrations 1.6 times higher than those requiring fewer devices independent of their gestational age, gender, or nutritional intake. Respiratory devices were associated with higher urinary BPA concentrations than other devices. These findings suggest that medical devices were an important source of ...
Bisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the environment. Adverse effects of BPA on animal reproductive health have been reported, however most of the studies relied on the approaches in the assessment of conventional histology and anatomical features. The mechanistic actions of BPA are not clear. In the present study, a murine model was used to study potential effects of BPA exposure during perinatal and postnatal periods on endocrine functions of hypothalamic-pituitary-gonadal (HPG)-axis. At the hypothalamic-pituitary level, BPA exposure resulted in the up-regulation of the expression levels of KiSS-1, GnRH and FSH mRNA in both male and female pups. At the gonadal levels, BPA caused inhibition in the expressions of testicular steroidogenic enzymes and the synthesis of testosterone in the male pups. Conversely exposure to BPA resulted in a greater aromatase expression level and the synthesis of estrogen in the female pups. BPA is a weak estrogen agonist ...
The list of adverse health effects from BPA exposure continues to grow. Bisphenol A, or BPA, is commonly used to line food and beverage cans, and helps to keep plastics flexible, but studies suggest the compound can leach into the foods we eat.
The list of adverse health effects from BPA exposure continues to grow. Bisphenol A, or BPA, is commonly used to line food and beverage cans, and helps to keep plastics flexible, but studies suggest the compound can leach into the foods we eat.
Octylphenol (OP) and nonylphenol (NP) are known to be endocrine disrupting agents and found as degradation products of industrial detergents, OP- and NP-polyethoxylates, in the natural environment. Previously, a bacterium (YTT) able to degrade OP and NP was isolated from a river sediment sample and identified as a novel species, Sphingobium amiense, in the class Alphaproteobacteria. In this study, we analyzed the whole genome sequence of strain YTT to characterize the OP degradation gene. Genomic DNA of the strain YTT sequenced by the whole-genome sequencing method with MiSeq and annotated using the BLASTP program. The total assembled genome was 4,565 kbp, for which 4,445 coding sequences were predicted. Prior to the genomic study, the mass spectrometry analysis revealed that octylhydroquinone and hydroquinone (HQ) were the intermediates of 4-tert-OP degradation by strain YTT . From the genomic analysis, the strain was found to possess the gene encoding octylphenol 4-monooxygenase, catalyzing ...
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Canadian Health Minister Tony Clement (pictured left) announced yesterday that Bisphenol A would be listed as a toxic substance and banned the use of polycarbonate plastic baby bottles. His Ministry will also tell baby food manufacturers to get it out of
Four new substances of very high concern (SVHCs), including Bisphenol A (BPA), has been added to the Candidate List based on proposals by France, Sweden, Germany and Austria, ECHA writes in a press release today. That brings the total number of substances on the Candidate List to 173.. BPA is a heavily debated chemical and ChemSec welcomes its inclusion on the Candidate List. Many companies have worked hard for years in order to substitute BPA and we hope that by now identifying it as an SVHC, even more alternatives will be available in the marketplace, says ChemSec Policy Advisor Frida Hök.. In addition to BPA, ChemSec would also like to see the similar substances Bisphenol S and Bisphenol F to be added to the Candidate List to avoid regrettable substitution. These substances are already on the SIN List due to their endocrine disrupting effects, along with BPA which was placed on the SIN List already from the start in 2008.. For the moment, BPA is formally identified as a reprotoxicant ...
Introduction: Breast cancer is the most common cancer occurring in women and causing the highest number of deaths among them. The role of xenoestrogens has been the subject of many studies in the pathogenesis of breast cancer. Less is known about the impact of xenoestrogens on the effectiveness...
The study, funded partly by the National Institutes of Health, joins a growing body of animal research showing the toxic health effects of BPA, including reproductive and developmental problems. Last August the U.S. Food and Drug Administration found BPA to be safe as currently used but later said more research on its safety is needed. BPA is used to make hard polycarbonate plastic, such as for baby bottles, refillable water bottles and food containers, as well as to make the linings of metal food cans ...
In this new study, researchers observed that exposure of human fœtal testicles to bisphenol A reduces the production of testosterone, and of another testicular hormone that is necessary for the testicles to descend into the sacs in the course of fœtal development. A concentration equal to 2 micrograms per litre of bisphenol A in the culture medium was sufficient to produce these effects. This concentration is equal to the average concentration generally found in the blood, urine and amniotic fluid of the population.. Testosterone is known to be produced by the testicle during the life of the fœtus, imposing masculinisation of the internal and external genitals which, in the absence of testosterone, develops spontaneously in the female direction. Furthermore, it is likely that testosterone also plays a role in the development of the testicle itself. Consequently, the current exposure of pregnant women to bisphenol A may be one of the causes of congenital masculinisation defects (of the ...
Coating the mouth with BPA-containing food, like soup, does not lead to higher than expected levels of BPA in blood, a new study in Toxicology and Applied Pharmacology shows. The study authors conclude that oral exposure does not create a risk for high exposures of BPA, also known as bisphenol A.
This topic contains 40 study abstracts on Bisphenol A indicating it may contribute to Prenatal Chemical Exposures, Bisphenol-A Toxicity, and Obesity
This topic contains 40 study abstracts on Bisphenol A indicating it may contribute to Prenatal Chemical Exposures, Bisphenol-A Toxicity, and Obesity
Oestrogen dominance also known as oestrogen excess, occurs when the level of oestrogen outweighs the level of progesterone in the body. This is said to be caused by a decrease in progesterone without a subsequent decrease in oestrogen. From a naturopathic perspective, oestrogen dominance is not only to do with internal hormone imbalance however even more so by external environmental oestrogens known as xenoestrogens.
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The ACQUITY UPLC Bisphenol A Method Kit is fully compliant with ASTM Method D7574-09. As described in this method, the ACQUITY solution provides optimum resolution and sensitivity for the analysis of Bisphenol A in water.
We have been discussing BPA-a component of polycarbonate and polyether plastics-forever. This should be #1000 on your list of things to worry about (#999 is being hit by a giraffe that fell off a skyscraper.) It doesnt matter what we say. The Environmental Working Group, and other geniuses have devoted their lives to finding something dangerous about it. Even though they failed in that quest, they will still get their way, unfortunately for science and for the people of California. It looks like its headed for Californias Proposition 65 list-a compilation of chemicals that are alleged to cause cancer, developmental toxicity, or both. Read more.. ...
The widespread use of natural and synthetic estrogens or chemicals with estrogenic activities is causing an increasing accumulation of estrogenic compounds in the environment. Already at very low concentrations these estrogenics can severely affect the wildlife, particularly in an aquatic environment. For these reasons measuring devices for detecting estrogen contaminations are in great demand. The majority of the analytical methods and bioassays on the market so far, lack semi-online adaptability, and usually cannot be used for automatic and continuous determination. Therefore, we have embarked on the development of new systems, which are able to fulfil those demands. The EstraMonitor combines recombinant A. adeninivorans G1212/YRC102-hERa-phyK yeast cells as the microbial component with an amperometric detection method to analyze estrogenic contaminations. A. adeninivorans G1212/YRC102-hERa-phyK was constructed by Kaiser et al. (2010). These cells were engineered to co-express the human ...
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DES is extremely important because it provides us with a historical lesson of how a synthetic estrogen, when given during pregnancy, caused a significant increase in breast cancer 20-30 years after its first use.
New research presents another cause for concern in regard to the chemical bisphenol A (BPA). The study is the first to examine what impact BPA has on the DNA of mammary glands as they age.
In 1938, DES (diethylstilbestrol) was the first synthetic estrogen to be created. DES was prescribed to millions of pregnant women, primarily from 1938 - 1971, but certainly not limited to those years. In some cases DES prescriptions were written into the 1980s in the U.S.
DiZio, J. P., Carlson, K. E., Bannochie, C. J., Welch, M. J., Angerer, E. von und Katzenellenbogen, J. A. (1992) Estrogen platinum-diamine complexes: preparation of a non-steroidal estrogen platinum-diamine complex labeled with platinum-191 and a study of its binding to the estrogen receptor in vitro and its tissue distribution in vivo. The Journal of steroid biochemistry and molecular biology 42 (3-4), S. 363-373 ...
You are viewing an interactive 3D depiction of the molecule 4,4-(2,3-diisocyano-1,3-butadiene-1,4-diyl)bisphenol (C18H14N2O2) from the PQR.
ARLINGTON, Va., Jan. 15 /PRNewswire-USNewswire/ -- American Chemistry Council Reacts to Statement from HHS and FDA on Bisphenol A.
(diethylstilbestrol), a nonsteroidal synthetic estrogen; once prescribed for some women during pregnancy to prevent miscarriages; banned for such use when discovered that…
Researchers have found that bisphenol-A (BPA) exposure in early life stages can actually cause gene expression changes, changing your brain and behavior.
BPA exposure is making us more susceptible to COVID-19. Action Alert! A new study, published in JAMA Network Open, found that those with the highest level of…
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