The IUPHAR/BPS Guide to Pharmacology. hydroxysteroid 11-beta dehydrogenase 1 - 1.-.-.- Oxidoreductases. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
Rabbit polyclonal Hydroxysteroid (17-beta) Dehydrogenase 4 antibody validated for WB, IHC, ICC/IF and tested in Human and Rat. Immunogen corresponding to…
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Accepted name: 17β-estradiol 17-dehydrogenase. Reaction: 17β-estradiol + NAD(P)+ = estrone + NAD(P)H + H+. Other name(s): 20α-hydroxysteroid dehydrogenase; 17β,20α-hydroxysteroid dehydrogenase; 17β-estradiol dehydrogenase; estradiol dehydrogenase; estrogen 17-oxidoreductase; 17β-HSD; HSD17B7. Systematic name: 17β-estradiol:NAD(P)+ 17-oxidoreductase. Comments: The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3β-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20α-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+.. Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9028-61-9. References:. 1. Kautsky, M.P. and Hagerman, D.D. 17β-Estradiol ...
Accepted name: 17β-estradiol 17-dehydrogenase. Reaction: 17β-estradiol + NAD(P)+ = estrone + NAD(P)H + H+. Other name(s): 20α-hydroxysteroid dehydrogenase; 17β,20α-hydroxysteroid dehydrogenase; 17β-estradiol dehydrogenase; estradiol dehydrogenase; estrogen 17-oxidoreductase; 17β-HSD; HSD17B7. Systematic name: 17β-estradiol:NAD(P)+ 17-oxidoreductase. Comments: The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3β-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20α-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+.. Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9028-61-9. References:. 1. Kautsky, M.P. and Hagerman, D.D. 17β-Estradiol ...
Complete information for HSD17B7P2 gene (Pseudogene), Hydroxysteroid 17-Beta Dehydrogenase 7 Pseudogene 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for HSD17B14 gene (Protein Coding), Hydroxysteroid 17-Beta Dehydrogenase 14, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016 ...
Thus, the two substrates of this enzyme are cholest-5-ene-3β,7α-diol and NAD+, whereas its 3 products are 7α-hydroxycholest-4-en-3-one, NADH, and H+. The systematic name of this enzyme class is cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase. This enzyme is also called 3β-hydroxy-Δ5-C27-steroid oxidoreductase. The human version of this enzyme is known as hydroxy-Δ-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7 or HSD3B7 which is encoded by the HSD3B7 gene.[2][3] ...
1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Fingerprint Dive into the research topics of Immunohistochemical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta. Together they form a unique fingerprint. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Next-day shipping cDNA ORF clones derived from HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 available at GenScript, starting from $99.00.
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If you want to increase testosterone levels naturally and dont want to consume any drugs then this article will help you to find the best foods which increase testosterone levels naturally. You should avoid using drugs as long as possible because your drugs can give you side effects later. Eggs - a healthy start: foods to increase testosterone #2. Eggs are among the foods to increase testosterone. A healthy breakfast at the start of the day is the most crucial meal of the day. It makes your body jumpstart for all the work that lies ahead. Testosterone also fosters the production of red blood cells, boosts mood, keeps bones strong, and aids thinking ability. Lack of testosterone, often nicknamed, low-t, can cause unwanted symptoms. Testosterone levels peak by early adulthood and drop as you age-about 1% to 2% a year beginning in the 40s. 25 foods that boost testosterone levels. The foods you eat affect your testosterone levels heavily. If youre looking to reap all the benefits associated with ...
Estradiol 17-beta-dehydrogenase 11,1.1.1.62,17-beta-hydroxysteroid dehydrogenase 11,17-beta-HSD 11,17bHSD11,17betaHSD11,17-beta-hydroxysteroid dehydrogenase XI,17-beta-HSD XI,17betaHSDXI,Cutaneous T-cell lymphoma-associated antigen HD-CL-03,CTCL-associated antigen HD-CL-03,Dehydrogenase/reductase SDR family member 8,Retinal short-chain dehydrogenase/reductase 2,retSDR2,Short chain dehydrogenase/reductase family 16C member 2,HSD17B11,DHRS8,PAN1B,SDR16C2,PSEC0029,UNQ207/PRO233,. ...
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By the product type, the market is primarily split into. DPGME ≥99.0%. DPGME ≥99.5%. Others. By the end users/application, this report covers the following segments. Coatings & Paints. Cleaners & Inks. Electronics. Chemical Additives. Others. Buy this report with price 3350$:. https://www.qyresearch.com/settlement/pre/a419779a513112b180fcb0d95af2defb,0,1,Global-Dipropyleneglycol-Methyl-Ether-DPGME-Market-Report-History-and-Forecast-Breakdown-Data-by-Manufacturers-Key-Regions-Types-and-Applicatio. Scope of Global Dipropyleneglycol Methyl Ether (DPGME) Market. The research report gives a wide overview of the new and emerging trends in the market. The report provides an assessment of the strengths and weaknesses of the market along with the other factors which are expected to hinder the market. It also explains the dynamics of Dipropyleneglycol Methyl Ether (DPGME) market in detail for a comprehensive understanding.. The drivers in the Dipropyleneglycol Methyl Ether (DPGME) market are all the ...
chemBlink provides information about CAS # 71939-51-0, alpha-Dihydroartemisinin methyl ether, (+)-alpha-Artemether, SM 229, alpha-Artemether, molecular formula: C16H26O5.
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[email protected]. LaRhee Henderson is an associate professor of Chemistry and chair of Biochemistry, Cell and Molecular Biology. She grew up on a small rural town in northwest Iowa and received her BS with a major in Chemistry from Morningside College in Sioux City, Iowa.. She then studied alanine racemase and received her PhD from the University of Nebraska in Lincoln, Nebraska. Professor Hendersons postdoctoral research focused on carnitine metabolism and was conducted at the University of Minnesota, St. Paul, Minnesota. As a research associate at Washington University, St Louis, Missouri, she isolated and characterized estradiol dehydrogenase.. Professor Henderson has been a professor in the Chemistry department at Drake since 1983. She teaches general chemistry, biochemistry, advanced biochemistry, introduction to molecular sciences and professional development. Her research experience has been in enzymology and biochemical education.. ...
The primary source of oestrogen in premenopausal women is the ovary but, after menopause, oestrogen biosynthesis in peripheral tissue is the exclusive site of formation. An enzyme group that affects the availability of active oestrogens is the 17β-hydroxysteroid dehydrogenase (17HSD) family. In breast cancer, 17HSD type 1 and type 2 have been mostly investigated and seem to be the principal 17HSD enzymes involved thus far. The question whether 17HSD type 1 or type 2 is of greatest importance in breast tumour development is still not clear. The aim of this study was to investigate how the loss of 17HSD type 2 expression, using siRNA in the non-tumour breast epithelial cells HMEC (human mammal epithelial cells) and MCF10A, and gain of 17HSD type 2 expression, using transient transfection in the breast cancer derived cell lines MCF7 and T47D, affect oestradiol conversion and proliferation rate measured as S-phase fraction. We further investigated how this was related to the endogenous expression ...
0005] One embodiment of the invention provides a method of detecting cancer or a predisposition to developing cancer in a subject. The method comprises determining an expression level of a cancer-associated polynucleotide, protein, or polypeptide selected from the group consisting of Titin; HBA1; Insulin-like growth factor 1 receptor (IGF1R); Isoform 3 of zonadhesin precursor; latent transforming growth factor beta binding protein 4 (LTBP4); ASXL1 (additional sex combs like 1); beta globin (HBB); BMP15-bone morphogenetic protein; TRIM49; DNAJ homolog subfamily B member 11 precursor; uncharacterized hematopoietic stem/progenitor cells protein MDS027; uncharacterized protein ALB; isoform 3 of sushi, nidogen and EGF-like domain-containing protein 1 precursor; isoform 2 of peripherin; mitochondrial 28S ribosomal protein S22; translation initiation factor EIF-2B subunit epsilon; estradiol 17-beta-dehydrogenase 1; XRCC6BP1; brain-specific angiogenesis inhibitor 1 precursor; isoform 2 of ring finger ...
N-Aminodihydrothebainonium methyl ether chloride | C19H27ClN2O3 | CID 5491707 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Taiwan e methyl ether(rg)/ACM30403000 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
TPM Solvent (Tripropylene Glycol Methyl Ether) is a safe alternative and effective solvent for several cleaning, stripping and coating applications.
(KudoZ) Polish to English translation of eter metylowy glikolu dipropylenowego: dipropylene glycol methyl ether [Chemistry; Chem Sci/Eng (Tech/Engineering)].
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C ...
Q9EQC1: 3 beta-hydroxysteroid dehydrogenase type 7; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; C(27) 3-beta-HSD; 1.1.1.-; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; 1.1. ...
Estrogens play a central role in the development of breast cancer. Most breast carcinomas are detected after menopause and despite a low degree of ovarian estrogen production and low levels of serum estrogen these tumors show a high in situ level of estrogens. Enzymes modulating local steroid availability seem to play an important role in the progression of especially estrogen receptor positive breast cancer. The 17ß-hydroxysteroid dehydrogenase (17ß-HSD) enzymes are involved in the interconversion of biologically active and inactive sex steroids and are considered to play a critical role in the in situ metabolism of estrogen.. The aim of this thesis was to investigate the expression of 17ß-HSD type 1 and 2 in breast cancer and correlate this to prognosis, and to analyze if the gene encoding 17ßHSD type 1 exhibits altered gene copy number in breast cancer. We also wanted to examine if the protein levels of aromatase, 17ßHSD type 1 and 17ßHSD type 2 show association with the expression of ...
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beta-peltatin A methyl ether: isolated from Mexican plant Bursera fagaroides; antitumor agent of podophyllotoxin (III) class; RN given refers to (5alpha,5beta,8aalpha)-isomer
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Pomegranate is a great source of gallic acid and ellagic acid.. Pomegranate juice contains 79.49 mg of gallic acid equivalent per liter as ellagitannins.[3] The various ellagitannins include granatin A and B, punicacortein A, B, C and D, 5-O-galloylpunicacortein D, punicafolin, punigluconin, punicalagin, 1-alpha-O-galloylpunicalagin, punicalin and 2-O-galloyl-punicalin. Other phenolics include delphinidin, cyanidin, and pelargonidin.. Pelargonidin is a potent inhibitor of MAO-B. Cyanidin and delphinidin are a moderate inhibitors of MAO-B.. Gallic acid induces Estradiol 17beta-dehydrogenase oxidation by 30%.[4] It also induces SULT1A1 and SULT1A3.[5] It also inhibits xanthine oxidase and aldehyde dehydrogenase.. Ellagic acid is a potent inhibitor of glutathione S-transferase enzymes GSTA1-1, GSTA2-2, GSTM1-1, GSTM2-2, and GSTP1-1.[6]. ...
tert-Butyl methyl ether for liquid chromatography LiChrosolv®. CAS 1634-04-4, EC Number 216-653-1, chemical formula (CH₃)₃COCH₃. - Find MSDS or SDS, a COA, data sheets and more information.
A theoretical study of the mechanism and kinetics of the H-abstraction reaction from dimethyl (DME), ethylmethyl (EME) and iso-propylmethyl (IPME) ethers by the ˙OH radical has been carried out using the high-level methods CCSD(T)/CBS, G3 and G3MP2BH&H. The computationally less-expensive methods of G3 and G3
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In this study, the sorption and pervaporation characteristics of the commercial PERVAP2256® membrane with methanol and tert-amyt methyl ether (TAME) mixtures were investigated. The feed concentration and the feed temperature ...
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Market study report Titled Global Methyl Ether Ketone Market 2019 Industry Research Report recently published on e-marketresearch.com is the key document for industries/clients to understand current global competitive market status. The Methyl Ether Ketone market study report base year is 2018 and provides market research data status (2013-2017) and forecast (2019-2025) and also categorizes the Methyl Ether Ketone market into key industries, region, type and application. Global Methyl Ether Ketone Market 2019 study report covers all major geographical regions and sub-regions in the world and concentrates on product sales, value, market size and growth opportunities in these regions. Competitive Analysis for Methyl Ether Ketone market industries/clients :- BASF, Dow Chemical, Solvay, Ashland, Celanese, Shell Chemicals Limited. Global Methyl Ether Ketone Market 2019 Industry Research Report provides current competitive analysis as well as valuable insights to industries/clients, which will ...
11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the conversion of the glucocorticoid corticosterone (cortisol in humans) to inert 11-dehydrocorticosterone (cortisone). 11 beta-HSD activity is present in the hippocampus, where it is induced by glucocorticoids and stress in vivo, prompting suggestions that the enzyme may attenuate the deleterious effects of chronic glucocorticoid excess on neuronal function and survival. Two isoforms exist: 11 beta-HSD1, a bidirectional NADPH-dependent enzyme, and 11 beta-HSD2, an NAD(+)- dependent exclusive 11 beta-dehydrogenase (corticosterone-inactivating enzyme). In this study, 11 beta-HSD1 activity and mRNA synthesis were demonstrated in primary fetal hippocampal cell cultures. Unexpectedly, the reaction direction in intact hippocampal cells was 11 beta- reduction (reactivation of inert 11-dehydrocorticosterone), although homogenization revealed that the enzyme was capable of 11 beta- dehydrogenation when removed from its normal cellular context. ...
There are 17 Chapters to deeply display the Europe Propylene Glycol Methyl Ether Acetate (PGMEA) for Electronic Materials market.. Chapter 1, to describe Propylene Glycol Methyl Ether Acetate (PGMEA) for Electronic Materials Introduction, product type and application, market overview, market analysis by countries, market opportunities, market risk, market driving force;. Chapter 2, to analyze the manufacturers of Propylene Glycol Methyl Ether Acetate (PGMEA) for Electronic Materials, with profile, main business, news, sales, price, revenue and market share in 2016 and 2017;. Chapter 3, to display the competitive situation among the top manufacturers in Europe, with sales, revenue and market share in 2016 and 2017;. Chapter 4, to show the Europe market by countries, covering Germany, UK, France, Italy and Russia, with sales, price, revenue and market share of Propylene Glycol Methyl Ether Acetate (PGMEA) for Electronic Materials, for each country, from 2012 to 2017;. Chapter 5 and 6, to show the ...
Härtill 5 uppsatser. Sammanfattningen = Chemical communications ; 1973:9. Available from: 2019-08-20 Created: 2019-08-20 Last updated: 2020-03-24Bibliographically approved ...
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TY - JOUR. T1 - 11 beta-hydroxysteroid dehydrogenase type 2 in mouse aorta - Localization and influence on response to glucocorticoids. AU - Christy, C AU - Hadoke, P W F AU - Paterson, J M AU - Mullins, J J AU - Seckl, J R AU - Walker, B R PY - 2003/10. Y1 - 2003/10. N2 - Both isozymes of 11 beta-hydroxysteroid dehydrogenase, which interconvert active and inactive glucocorticoids, are expressed in the mouse aortic wall. Mice deficient in 11HSD type 2 ( which converts active corticosterone into inert 11-dehydrocorticosterone) have hypertension and impaired endothelial nitric oxide activity. It has been suggested that 11HSD2 influences vascular function directly by limiting glucocorticoid-mediated inhibition of endothelium-derived nitric oxide. This study sought to determine (1) the cellular distribution of the 11HSD isozymes within the mouse aortic wall and (2) the influence of 11HSD2 on direct glucocorticoid-mediated changes in aortic function. Mouse aortas were separated into their component ...
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4FAL: Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80)
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Iodomethane solution 2.0 M in tert-butyl methyl ether, contains copper as stabilizer; CAS Number: 74-88-4; Synonyms: Methyl iodide; find Sigma-Aldrich-456756 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8 ...
There is limited information available from BenKinney et al. (1994), which prevents a full evaluation of the study. The test was conducted according to U.S. EPA guidelines, a WAF-method to prepare exposure solutions was used according to guidelines, and measured treatment concentrations were reported daily and found to be within 80% of nominal doses. A 96- ErC50 value of 184 mg/l was found in Pseudokirchneriella subcapitata (tested as Selenastrum capricornutum). According to the limited information available, the test is valid. The Hüls AG study (1991c) is done according to directive 88/302/EEC; the test seems valid although the results have been presented as nominal concentrations. The measured test concentrations after 72 hours do not deviate by more than 20 % from the freshly prepared test solutions. An EbC50 and ErC50 of ,800 in 72 hours (NOEC, 72 h, 470 mg/l) were found in P. subcapitata (tested as S. capricornutum). The test by Slovnaft VÚRUP, a.s. (2005) is done according to the OECD ...
Endometriosis is an estrogen dependent disease. Current medical therapies to inhibit estrogen biosynthesis and actions fail to prevent reoccurrence of the disea...
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