The role of IL-6 signalling in hypertensive heart disease and its sequelae is controversial. Our group demonstrated that Bazedoxifene suppressed IL-6/gp130 signalling in cancer cells but its effect on myocardial pathology induced by pressure overload is still unknown. We explored whether Bazedoxifene could confer benefits in wild-type C57BL/6J mice suffering from transverse aortic constriction (TAC) and the potential mechanisms in H9c2 myoblasts. Mice were randomized into three groups (Sham, TAC, TAC+Bazedoxifene, n = 10). Morphological and histological observations suggested TAC aggravated myocardial remodelling while long-term intake of Bazedoxifene (5 mg/kg, intragastric) attenuated pressure overload-induced pathology. Echocardiographic results indicated Bazedoxifene rescued cardiac function in part. We found Bazedoxifene decreased the mRNA expression of IL-6, MMP2, Col1A1, Col3A1 and periostin in murine hearts after 8-week surgery. By Western blot detection, we found Bazedoxifene exhibited ...

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TY - JOUR. T1 - Effects of 17beta-estradiol on survival, growth, sexual development and molting cycles of the marine crustacean mysid shrimp, Americamysis bahia.. AU - Hirano, Masashi. AU - Ishibashi, Hiroshi. AU - Watanabe, Naoko. AU - Matsumura, Naomi. AU - Watanabe, Akiko. AU - Onikura, Norio. AU - Kishi, Katsuyuki. AU - Shiratsuchi, Hideki. AU - Arizono, Koji. PY - 2004. Y1 - 2004. N2 - A 14-day partial life-cycle test was performed to assess the effects of 17beta-estradiol (E2) on the survival, growth, sexual development and molting cycles of a marine crustacean mysid shrimp (Americamysis bahia). Seven-day-old mysids were exposed to the nominal E2 concentrations of 31.3, 62.5, 125, 250 and 500 microg/l for 14 days. The total length and the body weight of mysids significantly decreased relative to the controls when exposed to 62.5, 250 and 500 microg/l E2 for 14 days. Moreover, the carapace length significantly decreased in the 500 microg/l E2 treatment groups. No significant differences ...

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Mechanism of the salutary effects of 17 beta-estradiol on cardiac function following trauma-hemorrhage: Inhibition of cardiomyocyte L-type calcium current (ICa-L ...

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... COLLEGEVILLE Pa. Sept. 19 /- WyethPharma...With regard to the safety and tolerability observed in this clinicalt...Wyeth received an approvable letter relating to its pending new druga...Bazedoxifene Significantly Reduced the Risk of New Vertebral Fracture...,Wyeth,Presents,Phase,3,Fracture,Data,for,Bazedoxifene,,an,Investigational,Therapy,for,Osteoporosis,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health

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இரு பக்கங்களிலுமுள்ள இடுப்பெலும்புகள் இரண்டும் முன்புறமாக ஒரு கசியிழையத்துடன் ஒட்டிக் காணப்படும். இடுப்பெலும்பின் ஒட்டும்பகுதி பூப்பென்புப் பகுதியாக இருப்பதனால் இந்தக் கசியிழையம் பூப்பென்பொட்டு (Pubic symphysis) என அழைக்கப்படுகின்றது. இடுப்பெலும்புகள் பின் புறமாகவும் திருவெலும்புடன் இணைந்திருப்பதனால், இந்த எலும்புகள் அனைத்தும் இணைந்து ஒரு முழுமையான வளையத்தை (Pelviv ring) ...

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(KudoZ) Spanish to English translation of sínfisis isquiopubiana: pubic symphysis / symphysis pubis [animal parts - Biology (-tech,-chem,micro-) (Science)].

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Information provided on this Web site is neither intended nor implied to be a substitute for professional medical advice. You should not use this information on this web site or the information on links from this site to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Pharma Professional Services advises you to always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.. You should check with your physician/health care provider before using any of the means or methods presented on this site. If you undertake any treatment methods displayed on this site without such supervision, you are solely and entirely responsible for its outcome. Pharma Professional Services nor anyone connected with this site cannot be held responsible for your actions nor any conditions resulting thereof.. ...

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Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL. The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife. 2018 11 29; 7 ...

Fanning, S.W.; Jeselsohn, R.; Dharmarajan, V.; Mayne, C.G.; Karimi, M.; Buchwalter, G.; Houtman, R.; Toy, W.; Fowler, C.E.; Han, R.; Laine, M.; Carlson, K.E.; Martin, T.A.; Nowak, J.; Nwachukwu, J.C.; Hosfield, D.J.; Chandarlapaty, S.; Tajkhorshid, E.; Nettles, K.W.; Griffin, P.R.; Shen, Y.; Katzenellenbogen, J.A.; Brown, M.; Greene, G.L. (2018) The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. eLife, 7, e37161. (Accompanied by a Related Insight article ...

Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Laine M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL. The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells. eLife. 2018. doi: 10.7554/eLife.37161 ...

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Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL. The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife. 2018 11 29; 7 ...

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