TY - JOUR. T1 - Erythrocyte deformability and its hemorheological consideration. AU - Shin, Sehyun. AU - Ku, Yunhee. AU - Park, Myung Su. AU - Suh, Jang Soo. PY - 2004/12/1. Y1 - 2004/12/1. N2 - The suspension of hardened erythrocytes (red blood cells) differs from the suspension of normal erythrocytes with respect to their rheological behavior. The deformability of normal and hardened erythrocytes (obtained by heating blood at 49°C or by incubating erythrocytes in a solution of hydrogen peroxide) was measured with a slit diffractometer and erythrocyte suspension viscosity was measured with a rotational viscometer. We found that when erythrocytes were heated at 49°C, with much less deformability than normal erythrocytes, their suspension viscosity was almost the same as the normal blood viscosity at high shear rates, whereas when erythrocytes were incubated in a solution of hydrogen peroxide, with an intermediate decrease of deformability, their suspension viscosity was greatly increased. The ...
The hemorheological profile in multiple myeloma (MM) has been extensively studied. Our investigation regarded the behavior of whole-blood viscosity, plasma viscosity and erythrocyte deformability in MM. We enrolled 24 MM patients; 13 of them had been
[Erythrocyte deformability: physiological aspects].: Analysis of published and authors data on the physiological role of deformability of erythrocytes, general
In this study, we investigated the effect of ginkgoglycoside in two different doses (19.2 mg/day and 28.8 mg/day) on blood viscosity and erythrocyte deformability in 27 patients suffering from cerebrovascular insufficiency. The patients were divided
INTRODUCTION: Hypertension is associated with microcirculatory disturbance, and erythrocyte deformability is a major determinant of the microcirculation. However, impairment of erythrocyte deformability in hypertensive patients in relation to antihypertensive treatment is unclear. The present study aimed to investigate this impairment in hypertensive patients under treatment using a highly sensitive and quantitative nickel mesh filtration technique. METHODS: Deformability was evaluated by filterability, defined as the flow rate of a hematocrit-adjusted erythrocyte suspension relative to that of saline under a specific filtration pressure in a pressure-flow curve obtained by continuous filtration. Baseline characteristics of hypertensive patients (n = 101) and age-matched normotensive subjects (n = 14) were obtained from medical records, and diabetic patients were excluded. RESULTS: Erythrocyte deformability in the hypertensive group was significantly (p = 0.010) lower (87.8 +/- 2.2 %) than that ...
This pilot study aimed to evaluate the differential effects of a remote ischemic preconditioning (rIPC) manoeuvre on performance and red blood cell (RBC) deformability compared to a sham control and a placebo setting. Ten male subjects performed three test settings in a single-blind, crossover, and randomized control design. All settings started with 20 min of rest and were followed by 4 cycles of occlusion/reperfusion consisting of 5 min each. During rIPC and placebo, the cuff pressure was inflated to 200 mmHg and 120 mmHg, respectively. During the sham control setting, 10 mmHg pressure was applied. All tests were followed by a cycle exercise with lactate diagnostics. Power at 2 and 4 mmol/l lactate thresholds were calculated. RBC deformability was measured before and after the respective manoeuvre. Results showed that no effect resulted from any manoeuvre on performance values or RBC deformability. But 6 subjects showed a higher power at the 2 mmol/l threshold, and 5 subjects exerted higher ...
Hemolytic anemia is one of the hallmarks of malaria and leads to an increase in oxidized heme (hemin) within the plasma of infected individuals. While scavenger proteins sequester much of the circulating heme, it has been hypothesized that extracellular heme may play a central role in malaria pathogenesis. W CSC100: Celebrating Canadian Chemistry
Dao and his colleagues are adapting sophisticated nanoscale measurement tools developed at the Nanomechanics Lab in conjunction with new biomechanical models to explore the behavior of host red blood cells infected by the deadliest of the malarial parasites, Plasmodium falciparum. The findings are helping to establish novel diagnostic devices as well as to identify new drugs and treatment targets that could eventually disrupt malaria-infection-induced changes in red blood cell deformability, stickiness, and shape. Altering these traits could potentially limit both the effects of malaria and the chances for infection ...
Cellular adhesion plays a critical role in biological systems and biomedical applications. Cell deformation and biophysical properties of adhesion molecules are of significance for the adhesion...
Abstract of Paper: Deformability of Erythrocytes and Factors Affecting it From Childhood to Old Age: A Comparative Study , Author: MOHAMED T. EL-GENGEHY, M.D.; ALAA E. IBRAHIM, M.D.; MOHAMED A. MOSTAFA, M.D.; NAZEH A. EL-NADY, M.D.; SALAH E. EL-ASHMAWY, M.D. and TAISSER K. EIADA, M.D. , Year: 1995 , Faculty of Medicine, Benha University
This thesis presents a systematic numerical modeling framework to simulate the stress-deformation and coupled stress-deformation-flow processes by performing uniaxial and biaxial compressive tests on fractured rock models with considering the effects of different loading conditions, different loading directions (anisotropy), and coupled hydro-mechanical processes for evaluating strength and deformability behavior of fractured rocks. By using code UDEC of discrete element method (DEM), a series of numerical experiments were conducted on discrete fracture network models (DFN) at an established representative elementary volume (REV), based on realistic geometrical and mechanical data of fracture systems from field mapping at Sellafield, UK. The results were used to estimate the equivalent Youngs modulus and Poissons ratio and to fit the Mohr-Coulomb and Hoek-Brown failure criteria, represented by equivalent material properties defining these two criteria.. The results demonstrate that strength ...
Ektacytometry was performed on RBC from the patient and his parents. Whole blood was mixed with isotonic buffer containing either Na+ or K+ ions and freed of white cells at room temperature. The suspensions were kept on ice, sequentially centrifuged and subjected to ektacytometry (1 h to 2 h) (Figure 1A). The osmoscans of both parents were super-imposable whether cells were pre-incubated with Na+- or K+-containing buffer. While the osmoscans of RBC from the mother (BN, BK) displayed a nearly normal pattern [see the corresponding control scan (con)], the two osmoscans from his fathers RBC (CN, CK) showed a left shift, implying a higher surface/volume ratio than normally observed, indicative of macrocytosis. The osmoscans from the patients RBC differed considerably from those of his parents and varied depending on the cation composition of the buffer (Figure 1A: AN, AK). When kept in Na+-containing buffer (AN), the RBC revealed a pattern similar to that seen for RBC from patients with hereditary ...
Several aspects of the behaviour of polyoma virus-transformed BHK cells in culture have suggested that they are more deformable than BHK cells. This possibility was tested by applying negative pressure at the cell surface by means of a micropipette. It was found that PyBHK cells in early mitosis are twice as deformable as BHK cells in the same stage. In addition, the taut, non-ruffling margins of both cell types when fully spread are much less deformable than the extending, ruffling leading lamella. The degree of deformability of these cells is correlated with the distribution and organization of microfilaments and consistent with this, deformability increases greatly in the presence of cytochalasin B. The significance of deformability studies such as these is discussed. ...
TY - JOUR. T1 - Influence of rheologic changes and platelet-neutrophil interactions on cell filtration in sepsis. AU - Kirschenbaum, Linda A.. AU - Aziz, Mohammed. AU - Astiz, Mark E.. AU - Saha, Dhanonjoy C.. AU - Rackow, Eric C.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - We examined the role of erythrocyte (red blood cell; RBC) aggregation and deformability, neutrophil (polymorphonuclear neutrophil; PMN) deformability, whole-blood viscosity, and platelet-neutrophil interactions on cell filtration in subjects who were critically ill with sepsis (CIS), critically ill noninfected subjects (CINS), and healthy controls (C). We assessed cell deformability by filtration through filters of 5-μm pore size. Whole blood, RBC, PMN, and combinations of PMN and RBC were studied. Viscometry was done on isolated RBC. Platelet-PMN interactions were assessed with monoclonal antibodies to CD41 and activated CD53 platelet receptors, and to CD66b PMN receptors. Filtration pressure (Pi) for CIS was significantly greater ...
PubMed journal article Blood viscosity and erythrocyte filterability: their evaluation in diabetes mellitu were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
TY - JOUR. T1 - Effects of sulfhydryl inhibition on red blood cells. II. Studies in vivo.. AU - JACOB, H. S.. AU - JANDL, J. H.. PY - 1962/7. Y1 - 1962/7. UR - http://www.scopus.com/inward/record.url?scp=0002880017&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0002880017&partnerID=8YFLogxK. U2 - 10.1172/JCI104607. DO - 10.1172/JCI104607. M3 - Article. C2 - 14450645. AN - SCOPUS:0002880017. VL - 41. SP - 1514. EP - 1523. JO - Journal of Clinical Investigation. JF - Journal of Clinical Investigation. SN - 0021-9738. ER - ...
In the development of malaria, the parasite, Plasmodium falciparum invades the human red blood cell and affects the deformability and adhesion capabilities of the cell. Mortality in these cases is generally caused by blockage of small blood vessels. The research in the Suresh lab involves collaborations with engineers, biologists and medical colleagues, and it revolves around measurement of the deformability and its connection to development of the parasite inside the cell. They use continuous force- displacement variations as measured by optical tweezers or other direct mechanical assays to study different stages of parasite development. Optical tweezers or optical trap technology uses a laser beam, focused by a highquality microscope objective, to trap silica particles attached to a living cell. The deformability is measured by calculating the force required to move the particle with the laser beam and determine a force versus deformability diagram as a function of cellular changes introduced ...
A reduction of uniaxial compressive strength (UCS) by the presence of water has been ascertained in many sedimentary rocks and even some metamorphic rocks experimentally. This paper reports and discusses the influence of water content and anisotropy on the strength and deformability of two meta-sedimentary rocks by triaxial compressive tests. Before conducting the triaxial tests, the physical properties of meta-siltstone and meta-sandstone specimens have been carefully examined. The water contents of both tested rocks are very low, for instance, 0.17% for meta-siltstone and 0.10% for meta-sandstone. The porosities of the tested rocks are analyzed by the technique of mercury intrusion porosimetry (MIP). It shows that the meta-sedimentary rocks have very low porosity, 0.18% for meta-siltstone and 0.53% for meta-sandstone on average. The thin section analysis reveals that the meta-siltstone contains more hydrophilic substances such as clay minerals than the meta-sandstone, and both two ...
Tzitzinou, A, Keddie, JL, Geurts, JM, Peters, ACIA and Satguru, R (2000) Film formation of latex blends with bimodal particle size distributions: Consideration of particle deformability and continuity of the dispersed phase ...
Single-cell deformability has been recently identified as a critical biomarker for various diseases and it varies considerably based on phenotypes. Current cell deformability measurement techniques, however, are inherently low throughput for statistical analysis of large heterogeneous biological samples. We focus on developing high-throughput microfluidic techniques for measuring intrinsic properties of single cells, including intracellular viscosity, membrane tension/elasticity and Youngs modulus. These measurements will allow us to identify potential genetic-alterations and phenotype-changes, responsible for modification in such properties of cells. Furthermore, systematic determination of single-cell mechanical properties in a rapid and standardized manner will expedite an adoption of aforementioned properties as new types of biomarkers for phenotype characterizations. These newly revealed biomarkers should provide efficient tools for determining the cell state and phenotype, which are ...
Human red blood cells, scanning electron micrograph (SEM). Red blood cells (RBCs), or erythrocytes, are the most common type of blood cell in vertebrates. RBCs take up oxygen in the lungs or gills and release it into tissues while squeezing through the bodys capillaries. The cytoplasm of RBCs is rich in haemoglobin, an iron-containing biomolecule that can bind oxygen and is responsible for the red colour of the cells. The cell membrane is composed of proteins and lipids and this structure provides properties essential for physiological cell function (deformability and stability) while traversing the circulatory system, especially the capillary network. In humans, mature RBCs are flexible and oval biconcave disks. RBCs are the most abundant type of cell in human blood, accounting for 40% of the blood volume. Magnification: x1,600 when shortest axis printed at 25 millimetres. - Stock Image C037/0700
Gas Separation Membranes. With the rise of energy costs, membrane technology for separating gases plays a significant role in reducing the environmental impact and costs of industrial processes. Polymer-based gas separation membranes offer advantages over conventional technologies (cryogenic distillation, amine absorption, etc.) including, low capital and operating costs, minimum energy requirements, ease of operation, and environmental friendliness. However, gas separation in polymers have reached a seemingly reached the trade-off between permeability and selectivity, as plotted on the 2008 Robeson plot. Inorganic membranes, on the other hand, display excellent permselectivity properties but incur high fabrication costs and lack membrane mechanical stability. Mixed-matrix membranes (MMMs) comprising thermally stable polymers and inorganic additives for target gases combines the polymers mechanical properties with the additives permselectivity properties. Our group focuses on MMMs consisting ...
At first glance, quite a few tissues in simple animals or in the early development look similar to an assembly of soap bubbles. The undeniable appeal of this correspondence, the seemingly elementary surface-tension Hamiltonian, and the prospect of a mechanical model of biological structures have fueled resea
SOLUTION: A physicist by training, Guck used laser beams in his graduate work to study the physical properties of cells. Not all cells are equally squishy, he found: while normal cells are relatively rigid, cancer cells are more pliable. "The more aggressive the cell, the softer it is, and that may be necessary for it to pass into tissues," Guck explains.. He suspected it might be possible to sort otherwise identical cells based on this phenomenon-and to do so without antibodies. Some interesting cell types and cancers have no known unique molecular identifiers, Guck notes. But deformability is an "inherent property" of cells, enabling label-free cell analysis. "The cell cannot help but have that property." Researchers had already developed one approach called deformability cytometry (DC), in which flowing cells smash head on into a wall of flowing liquid, deforming like crash-test dummies. Using an ultrahigh-speed camera, the method monitors 1,000 cells/second, but only for a few seconds, as ...
4.. M. A. Krishtal and A. P. Mokrov, "Hardening of layers formed during diffusion of molybdenum in iron and its alloys", Fiz. Metal. Metal.12, 3, 385 (1961).. ...
I used Baking Soda / Black strap Molasses Protocol. Mixed 1 Tea SP BS with 1 tea SP Molasses in 125ml water at 110 F or 43C for 5 minutes, added water to 300ml and drink 7AM and 7 PM you can t go mote than a week like that. After I used 1 BC 1 Molasses per day for one more week. After a 4 week break, using one lemon in a glass of water, I started BS again. Now my saliva/urine pH is 7.5. I have a BS in chemistry and know how to play the dangerous game with baking soda. You may consult your doctor ...
Using the DPD code built on an open-source software called LAMMPS (Large-scale Atomic/Molecular Massively Parallel Simulator) by Sandia National Laboratories, Peng says he and his co-researchers discovered that the surface area of RBCs plays an essential role in whether an RBC will pass the inter-endothelial slits. They found that a small reduction in RBC surface area (5 percent, for example) significantly increases the critical pressure necessary for RBCs to pass the spleen.. The form and behavior of an RBC, Peng explains, could, in certain respects, be considered analogous to a basketball. If air is added to a basketball, it becomes inflated and rigid; if the volume of air is decreased, the ball becomes much softer. Although an RBC is inflated with water rather than air, the principle is the same, he adds. Another important consideration in the dynamics, he notes, is the material of which the ball or the RBC consists, especially in terms of the membrane rigidity of the ball or the RBC.. Peng ...
Deformability of both individual base pairs and dimer steps is important for DNA sequence recognition. Parameters describing base-pair and dimer step geometry may be correlated with each other due to stereochemical interactions of adjacent bases in dimer
Six-row barley is the most economical to grow because the greater number of rows per head increases the per-acre yield. It is a warm-climate barley and is the type most widely grown in the United States. It is favored by domestic commercial breweries because it is rich in the enzymes needed to convert the adjuncts they employ (adjuncts may account for up to 60 percent of the extract in U.S. brews). Because six-row barley is high in protein, in all-malt brews it presents problems with clarity and stability. Its higher husk content improves mash filterability but can contribute harsh flavors, especially when brew-house practices cause hot-side aeration ...
Hemorheology, also spelled haemorheology (from the Greek αἷμα, haima "blood" and rheology), or blood rheology, is the study of flow properties of blood and its elements of plasma and cells. Proper tissue perfusion can occur only when bloods rheological properties are within certain levels. Alterations of these properties play significant roles in disease processes. Blood viscosity is determined by plasma viscosity, hematocrit (volume fraction of red blood cell, which constitute 99.9% of the cellular elements) and mechanical properties of red blood cells. Red blood cells have unique mechanical behavior, which can be discussed under the terms erythrocyte deformability and erythrocyte aggregation. Because of that, blood behaves as a non-Newtonian fluid. As such, the viscosity of blood varies with shear rate. Blood becomes less viscous at high shear rates like those experienced with increased flow such as during exercise or in peak-systole. Therefore, blood is a shear-thinning fluid. ...
Rheology - the study of the flow of matter and accompanying phenomena of real bodies deformation - in relation to blood - hemorheology. Blood viscosity - the main rheological parameter - has been studied in many research centers and among many different group of patients. The main disorders related to the hemorheological properties are: coronary insufficiency, vascular congestion, myocardial infarction, cerebral circulation disorder, Reynaud disease, ischemic limbs, diabetes, anemia, tumors. The following parameters are the main blood viscosity determinants: plasma viscosity, hematocrit, red cell deformability and erythrocytes aggregation. In hemorheological studies we used mathematical rheological models. The measurements of blood and plasma viscosity are performed by means of oscillating-rotary rheometers in order to determine the dependence of blood viscosity on the shear rate and the two components of the complex blood viscosity. Determination of blood cells aggregability and deformability ...
DESIGN: Randomized controlled trial.. METHODS: This research was carried out between April 2013 and January 2014 in the second hospital of Xiangya, Central South University in Changsha, China. Initially 96 cancer participants with PICC were chosen and randomly allocated to experimental and control group. The participants of the experimental group were conducted route PICC maintain technique and took acetylsalicylic acid 100 mg per day after dinner, while the control group received route PICC maintain technique only. The infusion speed and hemorheology indexes of the two groups were tested before our study and at the end of the 2nd and 4th months with several instruments.. RESULTS: Repeated measures analysis of variance indicated that taking acetylsalicylic acid orally had significant main effect on high shear blood viscosity and red blood cell deformability index (P , 0.05), and it also had significant main effect as well as time effect on plasma viscosity (P , 0.05); and time had significant ...
Recent studies have revealed that functional hyperemia is initiated in capillaries (14, 15) and that RBCs themselves can act as oxygen-sensing regulators to control capillary RBC velocity in response to local PO2 changes (15). However, the underlying mechanisms of how PO2 could modulate RBC velocity in capillaries are unknown. Experimental findings presented here implicate that deoxyHb-band 3 interactions in RBCs are the molecular switch that responds to local PO2 changes and controls RBC deformability and consequently RBC capillary velocity. Evidently, we showed that (i) while ex vivo capillary velocity and deformation of mRBC-WT and mRBC-subst 1-35 exhibited a linear relation with local PO2 changes, RBCs from transgenic mice that had enhanced or weakened deoxyHb-band 3 interactions showed capillary velocity and deformation independent of PO2. RBCs with enhanced deoxyHb-band 3 interactions showed higher capillary velocity and deformability compared to RBCs that had weakened deoxyHb-band 3 ...
Abstract. Rheologic properties of blood were studied in 8 patients with dilated cardiomyopathy (DCM) and in 10 healthy subjects. Whole-blood viscosity was measured at four different shear rates, by means of a computer-controlled rotational viscometer. The patients had significantly higher blood viscosity at all shear rates, both at their natural hematocrits and after an in vitro adjustment of sample hematocrits to 45%. Erythrocyte filterability (5 μm pore size) was significantly lower, fibrinogen concentration significantly higher, and HDLcholesterol concentration significantly lower in the patient group. No significant differences were found regarding hematocrit, mean corpuscular volume, haemoglobin concentration, leukocyte count and filterability (8 μm pore size), plasma viscosity, and total cholesterol concentration.. The measured hemorheologic abnormalities may contribute to the previously reported reduction of coronary blood flow reserve in DCM patients and to myocardial microcirculatory ...
Summary The foregoing experiment with cultures of Leptospira icteroides furnishes conclusive confirmatory evidence of the filterability of the organism. Whether it passes through the filter in its spiral form, assisted by its active motility, or in a granular phase, further experimental evidence may determine.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Red blood cells in a capillary (human central nervous system), coloured transmission electron micrograph (TEM). Red blood cells (RBCs), or erythrocytes, are the most common type of blood cell in vertebrates. They are involved in delivering oxygen to the body tissue. RBCs take up oxygen in the lungs or gills and release it into tissues while squeezing through the bodys capillaries. The cytoplasm of RBCs is rich in haemoglobin, an iron-containing biomolecule that can bind oxygen and is responsible for the red color of the cells. The cell membrane is composed of proteins and lipids and this structure provides properties essential for physiological cell function (deformability and stability) while traversing the circulatory system, especially the capillary network. In humans, mature RBCs are flexible and oval biconcave disks. Capillaries are the small blood vessels that make up the microcirculation of the human body. Magnification: x2,130 when shortest - Stock Image C032/0833
Band 3 mutations associated with HSt often produce an increased cation leak at low temperature (cryohydrocytosis; CHC). Patients with these variants show mild to moderate hemolytic anemia. Again, it is thought that the mutations responsible (Ser731Pro and His734Gln) affect the normal folding of band 3 and convert the protein into a cation conductor.4 Another mutation in band 3 has been identified as responsible for HSt Blackburn (Leu687Pro), in which affected erythrocytes share features of CHC and familial pseudohyperkalemia (see below), but the cation leak is not increased at low temperatures.4 Other band 3 mutants, originally classified as HS, have been reclassified as hereditary spherocytosis with a low temperature leak (HS-LTL) (Asp705Tyr and Arg760Gln) due to their increased cation leak at low temperatures.4 The known HSt point mutations in band 3 are illustrated in Figure 2, and occur in a restricted region of the trans-membrane domain of the protein. In the current issue of the journal, ...
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This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. These tags develop in the course of biochemical and structural alterations accompanying RBC aging, as the decrease of activities of multiple enzymes, the gradual accumulation of oxidative damage, the loss of membrane in form of microvesicles, the redistribution of ions and alterations in cell volume, density, and deformability. The actual tags represent the penultimate galactosyl residues, revealed by desialylation of glycophorins, or the aggregates of the anion exchanger (band 3 protein) to which anti-galactose antibodies bind in the first and anti-band 3 naturally occurring antibodies (NAbs) in the second case. While anti-band 3 NAbs bind to the carbohydrate-free portion of band 3 aggregates in healthy humans, induced anti-lactoferrin antibodies bind to the carbohydrate-containing portion of band 3 and along with anti-band 3 NAbs may accelerated ...
PFM on Red Blood Cell. Left: Topographic image of red blood cells, 30µm scan.. Right: Close-up of individual cell outlined in larger scan (left) and labeled as II. The piezoresponse ...
The application of steel fiber reinforced polymer (SRP) as a means of increasing the capacity of masonry columns is investigated in this study. The behavior of 23 solid-brick specimens that are externally wrapped by SRP sheets in low volumetric ratios is presented. The specimens are subjected to axial monotonic load until failure occurs. Two widely used types of masonry columns of differing square cross-sections were tested in compression (square and octagonal cross-sections). It is concluded that SRP-confined masonry behaves very much like fiber reinforced polymers (FRP)-confined masonry. Confinement increases both the load-carrying capacity and the deformability of masonry almost linearly with average confining stress. A comparative analysis between experimental and theoretical values computed in compliance with the Italian Council of Research (CNR) was also developed.
... - Model 304B CST (). The Capillary Suction Time has been used since the 1970s as a quick and reliable method for characterising sludge filterability and conditionability.
... - Model 304M CST (). The capillary Suction Time has been used since the 1970s as a quick and reliable method for characterising sludge filterability and conditionability.
Rheology concerns itself with materials that have aspects of both solids and liquids, and researches the flow and deformation of matter. Malvern Instr
The main function of RBCs is the transport of oxygen from the lungs to body tissues. All of the cells in this Wright-stained peripheral blood smear are normal RBCs.. ...
Correlates local cortical fluorescence with membrane movement. Quimp is based on the electrostatic contour migration method (ECMM) that consists of an improvement of a boundary tracking approach. It reduces sum of path lengths connecting all pairs of points, equivalent to minimizing the energy required for cell deformation. This tool is useful to study time series of several hundreds of cells per experimental condition.
Authors: Vayá, Amparo , Murado, Julián , Santaolaria, Marisa , Simó, María , Micó, Luisa , Calvo, Javier , Todolí, José , Ricart, Jose M. Article Type: Research Article Abstract: Atherothrombotic events are significant factors of mortality and morbidity in patients with systemic lupus erythematosus (SLE). The extent that rheological factors may be involved in these events in these patients has not been established. We measured the following rheological parameters in 86 patients with SLE, of whom 16 had suffered venous and/or arterial thrombotic events, and in 86 healthy controls: fibrinogen (Fbg), plasma viscosity (PV), blood viscosity at 230 s−1 both at native haematocrit (BVn 230 s−1 ) and corrected to 45% (BVc 230 s−1 ), erythrocyte aggregation at stasis (AE0 ) and at 3 s−1 (AE1 ), …aggregation time (Ta), aggregation index at 10 s (AI10 ), disaggregation threshold (γD), and erythrocyte deformability (ED). In addition glucose, total cholesterol (T-Chol), triglycerides (TG), ...
TY - JOUR. T1 - Hemorheological parameters in coronary artery disease. AU - Kesmarky, G.. AU - Toth, K.. AU - Habon, L.. AU - Vajda, G.. AU - Juricskay, I.. PY - 1998/7/1. Y1 - 1998/7/1. N2 - Hemorheological parameters are primary risk factors in ischemic heart disease (IHD). In the present study the relation of these parameters to the severity of coronary artery disease (CAD) was examined. The data of 109 patients (mean age: 55 ± 9 years) undergoing coronary angiography and 59 healthy controls (mean age: 35 ± 10 years) were analyzed. Hemorheological parameters (hematocrit, fibrinogen level, plasma viscosity (PV) and apparent whole blood Viscosity (WBV)) were determined and the circulatory index (CRI) was calculated. Patients were classified into three groups according to their coronary vessel state based on the coronary angiogram: Group 1 (n = 19, mean age: 53 ± 8 years) without significant CAD, Group 2 (n = 19, mean age: 51 ± 11 years) with single vessel disease, Group 3 (n = 71, mean age: ...
BACKGROUND: The aim of this study was to investigate the effects of red blood cell (RBC) transfusion on the hemorrheologic properties and microcirculatory hemodynamics in anemic hematology outpatients receiving 2 to 4 RBC units of either "fresh" (leukoreduced storage for less than 1 week) or "aged" (leukoreduced storage for 3-4 weeks) RBCs.. STUDY DESIGN AND METHODS: Measurements were performed before and 30 minutes after RBC transfusion in hematology outpatients. Leukoreduced RBC suspensions were stored in saline-adenine-glucose-mannitol (SAGM) additive solution. Whole blood viscosity was measured using Couette low-shear viscometry, RBC deformability and aggregability were measured using laser-assisted optical rotational cell analysis, and microcirculatory density and perfusion were assessed using sidestream dark field imaging.. RESULTS: One group of patients (n = 10) received a median (interquartile range) of 3 (2-3) RBC bags that were stored for 7 (5-7) days (fresh) and the other group of ...