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The major limitation of these studies is the cross- sectional design, 2010). Often problems show up readily in the urine, with changes nome generico do keflex as hematuria, cloudiness, gneerico foul odor seen with infection or concentrated dark-amber urine seen with dehydration. Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.
Literature References: Ergosterol biosynthesis inhibitor. Prepn: A. Hubele, P. Riebli, GB 2098607 (1982 to Ciba-Geigy). Properties and antifungal activity: W. Ruess et al., Brighton Crop Prot. Conf. - Pests Dis. 1988, 543. Field studies: A. J. Leadbeater et al., ibid. 917; A. B. Bassi, Jr. et al., Br. Crop Prot. Counc. Monogr. 57, 91 (1994). Uptake and translocation in crops: H. Dahmen, T. Staub, Plant Dis. 76, 523 (1992). ...
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Ergosterol is the major sterol found in the membranes of Chlamydomonas reinhardtii. While past studies have identified some ergosterol mutants in C. reinhardtii, very little is known about sterol biosynthesis pathways in this species. With the elucidation of the Chlamydomonas genome, bioinformatics analysis has allowed us to determine potential genes involved in ergosterol biosynthesis. With this knowledge, a working model of the pathway was designed for future analysis. Several of the ergosterol biosynthetic genes were analyzed in respect to their role and involvement in flagellar regeneration. These genes were upregulated during the regrowth of the flagella. Also Chlamydomonas strains lacking flagella were analyzed by Q-RT PCR to determine what role ergosterol biosynthetic genes played in the absence of their flagella. Finally, one of the genes with homology to the yeast sterol C-5 desaturase, ERG3, was chosen for further analysis. To test whether ERG3 of C. reinhardtii had a similar function, yeast
Theodore White, professor and dean of the School of Biological Sciences at the University of Missouri, Kansas City, will present "The Ins and Outs of Antifungal Drug Resistance" as part of the Division of Biology Seminar Series at 4 p.m. Friday, Oct. 14, in 221 Ackert Hall.. Whites lecture will provide a cross section of issues that contribute to antifungal drug resistance in pathogenic fungi. White will discuss the basic mechanisms, the transcriptional regulators and generalized mechanisms across funal species. He will present current understanding of how a series of 17 clinical isolates developed high level resistance. White also will discuss his recent work on how Azole antifungals are imported into cells, and genes in the ergosterol pathway and their contributions to antifungal resistance and to the responses to other environmental stressors.. ...
Soil samples originated at a long-term field experiment in Abisko, northern Sweden (681210N, 181490E). The samples are from 36 plots, with three subsamples from each plot (at two different horizons, one from the lower and two from the upper), giving a total of 108 samples. Soil organic matter (SOM) was measured as loss on ignition at 550 ˚C, and ergosterol concentration was determined through HPLC.. ...
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Serine/threonine Akt kinase is a key regulator of a wide range of cellular pathways including growth, proliferation, and survival. Accordingly, deregulation of Akt plays a key role in the onset or propagation of cancer. We found that dynAP is a novel modulator of Akt activation, warranting dynAP as a potential target for developing anticancer drugs. In addition, the involvement of Akt in the metabolic control (lipid and glucose) has been widely accepted, and recently, the importance of Akt has been implicated in the neuronal function (17, 18). Expression of dynAP therefore may profoundly affect other disease conditions such as diabetes mellitus and neurodegenerative diseases. The cellular content of dynAP seemed to be correlated with its mRNA level, and SV40 transformation provoked dynAP expression in the normal fibroblasts that did not express dynAP. These results may suggest that the expression of the dynAP gene is under the control of a tumor suppressor (Rb or p53) at the transcriptional ...
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The dimorphic fungus Candida albicans is a commensal of the human oral, gastrointestinal, vaginal, cutaneous, and mucosal surfaces. In immunocompetent as well as immunocompromised individuals, C. albicans causes cutaneous or subcutaneous infections such as vaginitis or oral thrush or infections of the nails and skin. In patients receiving broad-spectrum antibiotics or undergoing cancer chemotherapy, C. albicans can enter the bloodstream to cause serious systemic invasive disease (6, 38). Due to the difficulty in identifying antifungal targets unique to fungi that are not shared with the human host, only a restricted number of antifungal agents have been widely used for treating C. albicans systemic infections (12, 32). One such target unique to fungi is the sterol cell membrane component ergosterol.. Fluconazole is a member of the azole class of drugs that target an essential enzyme (Erg11; lanosterol 14α-demethylase) in the ergosterol biosynthetic pathway (36, 37). Fluconazole is the most ...
The nematode Caenorhabditis elegans is a genetically tractable model organism to investigate sterol transport. In vivo imaging of the fluorescent sterol, dehydroergosterol (DHE), is challenged by C. elegans high autofluorescence in the same spectral region as emission of DHE. We present a method to detect DHE selectively, based on its rapid bleaching kinetics compared to cellular autofluorescence. Worms were repeatedly imaged on an ultraviolet-sensitive wide field (UV-WF) microscope, and bleaching kinetics of DHE were fitted on a pixel-basis to mathematical models describing the intensity decay. Bleach-rate constants were determined for DHE in vivo and confirmed in model membranes. Using this method, we could detect enrichment of DHE in specific tissues like the nerve ring, the spermateca and oocytes. We confirm these results in C. elegans gut-granule-loss (glo) mutants with reduced autofluorescence and compare our method with three-photon excitation microscopy of sterol in selected tissues. Bleach
The nematode Caenorhabditis elegans is a genetically tractable model organism to investigate sterol transport. In vivo imaging of the fluorescent sterol, dehydroergosterol (DHE), is challenged by C. elegans high autofluorescence in the same spectral region as emission of DHE. We present a method to detect DHE selectively, based on its rapid bleaching kinetics compared to cellular autofluorescence. Worms were repeatedly imaged on an ultraviolet-sensitive wide field (UV-WF) microscope, and bleaching kinetics of DHE were fitted on a pixel-basis to mathematical models describing the intensity decay. Bleach-rate constants were determined for DHE in vivo and confirmed in model membranes. Using this method, we could detect enrichment of DHE in specific tissues like the nerve ring, the spermateca and oocytes. We confirm these results in C. elegans gut-granule-loss (glo) mutants with reduced autofluorescence and compare our method with three-photon excitation microscopy of sterol in selected tissues. Bleach
Terbinafine is an allylamine antifungal medication. The medication can be administered orally or topically as a cream. The topical treatment was officially approved by the FDA in 1993 and can be bought over the counter. The oral treatment was approved in 1996 and widely distributes in the central nervous system, hair and nail beds and may remain there for up to three months because of extended elimination from skin and adipose tissue. Terbinafine is metabolized in the liver and 70% is excreted in the urine.. Mechanism: Terbinafine has a fungicidal effect by inhibiting the enzyme squalene monooxygenase which is involved in the synthesis of sterol in fungi. This inhibits fungal sterol biosynthesis by decreasing ergosterol levels. Fungal membranes are not able to grow because ergosterol is one of the main components of the fungal cell membrane. Additionally, squalene accumulates which weakens the cell membrane. Orally, the drug is very effective due to its ability to concentrate within the ...
Wild-type Saccharomyces cerevisiae do not accumulate exogenous sterols under aerobic conditions, and a mutant allele conferring sterol auxotrophy (erg7) could be isolated only in strains with a heme deficiency. delta-Aminolevulinic acid (ALA) fed to a hem1 (ALA synthetase-) erg7 (2,3-oxidosqualene cyclase-) sterol-auxotrophic strain of S. cerevisiae inhibited sterol uptake, and growth was negatively affected when intracellular sterol was depleted. The inhibition of sterol uptake (and growth of sterol auxotrophs) by ALA was dependent on the ability to synthesize heme from ALA. A procedure was developed which allowed selection of strains which would take up exogenous sterols but had no apparent defect in heme or ergosterol biosynthesis. One of these sterol uptake control mutants possessed an allele which allowed phenotypic expression of sterol auxotrophy in a heme-competent background.
Candida albicans is an endogenous opportunistic yeast that does not cause infections in healthy individuals. However, disruption of the balance between microbiome and microorganism, the commensal form becomes pathogenic with clinical manifestation. The aim ofthis study was to determine the effect of oleuropein and hydroxytyrosol and their mechanism of action in C. albicans in vitro. Using the SQM approach for modulation ofergosterol synthesiswe found that oleuropein and hydroxytyrosol in concentrations below the MIC after 18 hours of incubation at 35 °C showed their interference in ergosterol biosynthesis pathway. The testing of the effect of hydroxytrosol and oleuropein on the inhibition of blastospore germination of C. albicans showed that after 3 hours of incubation at 37 °C oleuropein and hydroxytyrosol inhibit the germination even in values below MIC affecting the cellular signal pathways (cAMP-PKA). The testing of inhibition of growth of filaments reveals that oleuropein and ...
In this study, we demonstrate that yeast ORPs can interact with two membranes simultaneously and facilitate regulated sterol transfer by a novel mechanism. Using Osh4p as a representative Osh protein, we identified a membrane-binding site on Osh4p that is distal to the membrane-binding surface near the mouth of the sterol-binding pocket. Our findings suggest that lipid content of the liposome interacting with the distal membrane-binding surface affects the rate of sterol extraction from and delivery to the second liposome. We confirmed the functional importance of the distal membrane-binding surface of Osh4p by altering it and showing that the mutant protein cannot replace the wild-type protein or facilitate sterol transfer in cells and that it is insensitive to the stimulatory effect of PI(4,5)P2 on sterol transfer in vitro. Because all yeast ORDs can bind two membranes simultaneously, they likely all have similar regulatory distal membrane-binding surfaces, although they almost certainly ...
TY - JOUR. T1 - Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. AU - Wang, Jin. AU - Zhang, Da Wei. AU - Lei, Ying. AU - Xu, Fang. AU - Cohen, Jonathan C.. AU - Hobbs, Helen H.. AU - Xie, Xiao Song. PY - 2008/5/6. Y1 - 2008/5/6. N2 - ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette half-transporters that limit intestinal uptake and promote biliary secretion of neutral sterols. Here, we describe the purification of endogenous G5G8 from mouse liver to near homogeneity. We incorporated the native proteins into membrane vesicles and reconstituted sterol transfer. Native gel electrophoresis, density-gradient ultracentrifugation, and chemical cross-linking studies indicated that the functional native complex is a heterodimer. No higher order oligomeric forms were observed at any stage in the catalytic cycle. Sterol transfer activity by purified native G5G8 was stable, stereospecific, and selective. We also report that G5 but not G8 is S-palmitoylated and that ...
A post-doctoral position is available in the research group of Associate Prof. Maike Bublitz at the Department of Biochemistry, University of Oxford. The project aims to understand the structure and function of fungal membrane transport proteins identified as potential new drug targets, using a combination of state-of-the-art structural (X-ray crystallography, cryo-EM) and biochemical/biophysical techniques.. Applicants should hold a PhD in a relevant subject area, such as membrane protein biochemistry or structural biology. Experience in native or recombinant membrane protein expression, purification and either structural determination or functional analysis using biochemical and biophysical techniques is essential. Ability to work in a team as well as contribute to supervision activities and excellent verbal and written communication skills are expected. Experience in protein X-ray crystallography and/or cryo-EM is an advantage.. To apply for this role and for further details, including the ...
Ojserkis, Bennett E., "The effect of sterol composition on the activities of membrane-bound enzymes in mouse L cells." (1974). Summer and Academic Year Student Reports. 609 ...
C-5 Sterol Desaturase; Glycoprotein That Catalyzes The Introduction Of A C-5(6) Double Bond Into Episterol, A Precursor In Ergosterol Biosynthesis; Mutants Are Viable, But Cannot Grow On Non-fermentable Carbon Sources; Substrate Of The HRD Ubiquitin Ligase
C-5 Sterol Desaturase; Glycoprotein That Catalyzes The Introduction Of A C-5(6) Double Bond Into Episterol, A Precursor In Ergosterol Biosynthesis; Mutants Are Viable, But Cannot Grow On Non-fermentable Carbon Sources; Substrate Of The HRD Ubiquitin Ligase
Nervat e caktuara për zorrën e trashë, tek disa persona janë shumë të ndieshme, gjë e cila çon në çrregullimin e saj si pasojë e ngrënies së disa lloj ushqimesh të veçanta (intolerancës ndaj disa ushqimeve si ushqimeve të skuqura, alkoolit, qumështit, çokollatave, lëngut të domates, kafesë etj.), ose si pasojë e një çrregullimi nervor, ose si pasojë e ndonjë frike të madhe apo zemërimi të madh, e ngjashëm me këto gjendje emocionale. Atëherë, gazrat mblidhen në zorrë në përmasa të mëdha dhe ngrihen lart duke shtypur të dyja anët e barkut ose njërën prej tyre, sidomos anën e majtë, dhe kjo shkakton shtypje të stomakut dhe ndienjën e ngopjes dhe fryrjes, dhe si pasojë shtypjen e shtresës ndarëse, dhe kjo e fundit shkakton ngushtim në gjoks dhe në frymëmarrje. Ndonjëherë këto gazra ngjiten deri në tru dhe shkaktojnë dhimbje koke, gjendje e cila ndonjëherë çon në ndienjën e frikës apo mërzitjes së menjhershme dhe papritmas, mandje ...
Këngëtarja Fergie ka folur me guxim për luftën e saj ndaj varësisë prej narkotikëve.. Fergie ka hapur zemrën dhe ka folur për luftën me psikozën dhe demencën.. Gjatë kohës së ndarjes nga ish-bashkëshorti, Fergie ka zbuluar se si në moshë të re nuk e kishte aspak të lehtë.. Ajo thotë se eksperimentet me drogë e sollën deri te problemet e vështira shëndetësore.. "Kisha prekur fundin. Kam vuajtur nga psikoza dhe demenca. Kisha halucinacione", ka pranuar Fergie.. Ajo ka zbuluar edhe pasojat që kishte bartur pas konsumimit të drogës.. "Doja të ulesha në hapësirë të mbyllur ku më shfaqeshin bletë dhe lepuri", ka thënë këngëtarja.. Në fillim kjo i dukej argëtuese, por shumë shpejt kuptoi se deri ku kishte arritur.. "Dita kur ndalova të argëtohesha ishte dita kur forca, besimi dhe shpresa ime u zgjuan për diçka më të mirë", tha ajo për Daily Mail.. Ajo në këtë intervistë po ashtu diskutoi shkurtimisht divorcin me Josh Duhamelit, pas tetë vjet ...
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Withaferin A is a steroidal lactone, derived from Acnistus arborescens, Withania somnifera (Indian Winter cherry or Ashwagandha in Sanskrit) and other members of Solanaceae family. It has been traditionally used in ayurvedic medicine. It is the first member of the withanolide class of ergostane type product to be discovered. This natural product has wide range of pharmacological activities including cardioprotective, anti-inflammatory, immuno-modulatory, anti-angiogenesis, anti-metastasis and anti-carcinogenic properties. Withanolides are a group of naturally occurring C28- steroidal lactones. They contain four cycloalkane ring structures, three cyclohexane rings and one cyclopentane ring. Withaferin A is highly reactive because of the ketone-containing unsaturated A ring, the epoxide in the B ring, and the unsaturated lactone ring. The double bond in ring A and the epoxide ring are mainly responsible for the cytotoxicity. The 22nd and 26th carbons of the ergostane skeleton in withaferin A and ...
Cervical cancer is caused by human papilloma virus (HPV) expressing E6 and E7 oncoproteins, which are known to inactivate tumor suppressor proteins p53 and pRb, respectively. Repression of HPV oncoproteins would therefore result in reactivation of tumor suppressor pathways and cause apoptosis in cancer cells. Withaferin A (WA), the active component of the medicinal plant Withania somnifera, has exhibited inhibitory effects against several different cancers. We examined the activity of WA on human cervical cancer cells in vitro and in vivo. WA potently inhibited proliferation of the cervical cancer cells, CaSki (IC(50) 0.45 ? 0.05 ?M). Mechanistically, WA was found to (i) downregulate expression of HPV E6 and E7 oncoproteins, (ii) induce accumulation of p53, (iii) increase levels of p21(cip1/waf1) and its interaction with proliferating cell nuclear antigen (PCNA), (iv) cause G(2)/M cell cycle arrest, associated with modulation of cyclin B1, p34(cdc2) and PCNA levels, (v) decrease the levels of ...
... and upregulation of tumor suppressor proteins in human cervical cancer cells ...
In Saccharomyces cerevisiae, the Rho-type GTPase Cdc42 regulates polarized growth through its effectors, including the p21-activated kinases (PAKs) Ste20, Cla4, and Skm1. Previously, we demonstrated that Ste20 interacts with several proteins involved in sterol synthesis that are crucial for cell polarization. Under anaerobic conditions, sterols cannot be synthesized and need to be imported into cells. Here, we show that Ste20, Cla4, and Skm1 form a complex with Sut1, a transcriptional regulator that promotes sterol uptake. All three PAKs can translocate into the nucleus and down-regulate the expression of genes involved in sterol uptake, including the Sut1 targets AUS1 and DAN1 by a novel mechanism. Consistently, deletion of either STE20, CLA4, or SKM1 results in an increased sterol influx and PAK overexpression inhibits sterol uptake. For Ste20, we demonstrate that the down-regulation of gene expression requires nuclear localization and kinase activity of Ste20. Furthermore, the Ste20
The increasing availability of omics databases provide important platforms for yeast engineering strategies since they offer a lot of information on the physiology of the cells under diverse growth conditions, including environmental stresses. Notably, only a few of these approaches have considered a performance under recombinant protein production conditions. Recently, we have identified a beneficial effect of low oxygen availability on the expression of a human Fab fragment in Pichia pastoris. Transcriptional analysis and data mining allowed for the selection of potential targets for strain improvement. A first selection of these candidates has been evaluated as recombinant protein secretion enhancers. Based on previous transcriptomics analyses, we selected 8 genes for co-expression in the P. pastoris strain already secreting a recombinant Fab fragment. Notably, WSC4 (which is involved in trafficking through the ER) has been identified as a novel potential target gene for strain improvement, with up
The main chemical constituents are alkaloids and steroidal lactones. These include tropine and cuscohygrine. The leaves contain the steroidal lactones, withanolides, notably withaferin A, which was the first to be isolated from the plant.[citation needed] Tropine is a derivative of tropane containing a hydroxyl group at third carbon. It is also called 3-tropanol. Benzatropine and etybenzatropine are derivatives of tropine. It is also a building block of atropine, an anticholinergic drug prototypical of the muscarinic antagonist class. Cuscohygrine is a pyrrolidine alkaloid found in coca.
File Title: Physiological, biochemical, and genetic studies on the [delta]24 sterol methyltransferase of Saccharomyces cerevisiae ...
Grupi Patriotik Atdhetar Çamëria eshte organ i Shoqerive Politike Atdhetare Çamëria ne Diaspore. Qellimi i ketij grupi eshte informimi, sensibilizimi dhe MOBILIZIMI i publikut shqiptar, nderkombetar dhe te huaj rreth GJENOCIDIT DHE DRAMES ÇAME dhe zgjidhjes se saj. Kjo liste organizon here pas here studime dhe debate konstruktive per zgjidhjen dhe nderkombetarizimin e çeshtjes çame. Çdo anetar eshte i lire te postoje edhe shkrime qe nuk kane lidhje me Çamërine por qellimi kryesor i kesaj liste eshte dhe mbetet çeshtja çame, islame dhe shqiptare ne Ballkan. Per te pare fotot dhe deshmite e vjetra historike te Çamerise lexuesit duhet te behen anetare te grupit. Motoja jone eshte: = | MOS PYET CFARE KA BERE CAMERIA PER TY | = = | POR THUAJ CFARE KAM BERE UNE PER CAMERINE! | =
Grupi Patriotik Atdhetar Çamëria eshte organ i Shoqerive Politike Atdhetare Çamëria ne Diaspore. Qellimi i ketij grupi eshte informimi, sensibilizimi dhe MOBILIZIMI i publikut shqiptar, nderkombetar dhe te huaj rreth GJENOCIDIT DHE DRAMES ÇAME dhe zgjidhjes se saj. Kjo liste organizon here pas here studime dhe debate konstruktive per zgjidhjen dhe nderkombetarizimin e çeshtjes çame. Çdo anetar eshte i lire te postoje edhe shkrime qe nuk kane lidhje me Çamërine por qellimi kryesor i kesaj liste eshte dhe mbetet çeshtja çame, islame dhe shqiptare ne Ballkan. Per te pare fotot dhe deshmite e vjetra historike te Çamerise lexuesit duhet te behen anetare te grupit. Motoja jone eshte: = | MOS PYET CFARE KA BERE CAMERIA PER TY | = = | POR THUAJ CFARE KAM BERE UNE PER CAMERINE! | =
Nga Lorena Stroka. Pjesa dërrmuese e njerëzve anembanë botës e nis ditën me kafe, ankesa dhe shumë ankth për angazhimet vijuese. Një rutinë e trashguar, e cila sa vjen e përkeqësohet…. Sipas kanalit shkencor ASAP, koha më e papërshtatshme për të konsumuar kafe është mëngjesi, për shkak të vlerave të larta të kortizolit në trupin e njeriut, kryesisht gjatë asaj ore.. Kjo do të thotë se konsumi i kafesë në këtë kohë krijon dy probleme madhore: Së pari, kafeina ndikon prodhimin e kortizolit në organizëm, një hormoni që lirohet si "përgjigje" ndaj stresit dhe niveleve të ulta të glukozës në gjak. Kështu, trupi prodhon më pak kortizol dhe bazohet më shumë te kafeina për të plotësuar mangësinë. Së dyti, të gjithë ata që konsumojnë kafe në mëngjes, pa e ditur, rrisin rezistencën e trupit ndaj kafeinës, për shkak të të lartpërmendurave.. Pas të gjitha këtyre, mendoj se ka ardhur koha që popullsia botërore të ndryshojë zakon. Sipas ...
Përdorimi dhe botimi i lajmeve mund të bëhet vetëm me kusht që autorësia të ruhet dhe të vendoset në mënyrë të qartë burimi i lajmit dhe materialit. Çfarëdo kundërveprimi në këtë drejtim do të bëhet subjekt i procedurave përkatëse. Lajmet dhe materialet të vendosura në insajderi.com të cilat janë të huazuara nga mediume apo portale të tjera mbeten e drejtë e patjetërsueshme e mediumeve përkatëse.. Përdorimi dhe botimi i lajmeve mund të bëhet vetëm me kusht që autorësia të ruhet dhe të vendoset në mënyrë të qartë burimi i lajmit dhe materialit. Çfarëdo kundërveprimi në këtë drejtim do të bëhet subjekt i procedurave përkatëse. Lajmet dhe materialet të vendosura në insajderi.com të cilat janë të huazuara nga mediume apo portale të tjera mbeten e drejtë e patjetërsueshme e mediumeve përkatëse.. Për më shumë drejtohuni në [email protected]. ...
Përdorimi dhe botimi i lajmeve mund të bëhet vetëm me kusht që autorësia të ruhet dhe të vendoset në mënyrë të qartë burimi i lajmit dhe materialit. Çfarëdo kundërveprimi në këtë drejtim do të bëhet subjekt i procedurave përkatëse. Lajmet dhe materialet të vendosura në insajderi.com të cilat janë të huazuara nga mediume apo portale të tjera mbeten e drejtë e patjetërsueshme e mediumeve përkatëse.. Përdorimi dhe botimi i lajmeve mund të bëhet vetëm me kusht që autorësia të ruhet dhe të vendoset në mënyrë të qartë burimi i lajmit dhe materialit. Çfarëdo kundërveprimi në këtë drejtim do të bëhet subjekt i procedurave përkatëse. Lajmet dhe materialet të vendosura në insajderi.com të cilat janë të huazuara nga mediume apo portale të tjera mbeten e drejtë e patjetërsueshme e mediumeve përkatëse.. Për më shumë drejtohuni në [email protected]. ...
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erg".. Το 2015 απόκτησε την: «Πιστοποίηση στην Κολποσκόπηση», στα πλαίσια του 13ου Ευρωπαϊκού Σεμιναρίου Κολποσκόπησης & Παθολογίας Τραχήλου, Αθήνα, 20/6/2015.. Απόκτησε τον τίτλο του Διδάκτορα της Ιατρικής Σχολής του Πανεπιστημίου Αθηνών τον 6ο/2016, μετά από την υποστήριξη του θέματος: «Η αξία των μεθοδολογιών λήψης απόφασης στην αύξηση της διαγνωστικής ακρίβειας της κυτταρολογίας του ενδομητρίου».. Το χρονικό διάστημα μεταξύ 9/2013 - 8/2016 διετέλεσε Πανεπιστημιακός υπότροφος (τ. βαθμίδα Λέκτορα) της Γ Μαιευτικής και Γυναικολογικής κλινικής της Ιατρικής Σχολής ...
Withanolide D Induces Apoptosis in Leukemia by Targeting the Activation of Neutral Sphingomyelinase-Ceramide Cascade Mediated by Synergistic Activation of C-Jun N-Terminal Kinase and P38 Mitogen-Activated Protein Kinase. ...
Spore germination in Saccharomyces cerevisiae is a process in which a quiescent cell begins to divide. During germination, the cell undergoes dramatic changes in cell wall and membrane composition, as well as in gene expression. To understand germination in greater detail, we screened the S. cerevisiae deletion set for germination mutants. Our results identified two genes, TRF4 and ERG6, that are required for normal germination on solid media. TRF4 is a member of the TRAMP complex that, together with the exosome, degrades RNA polymerase II transcripts. ERG6 encodes a key step in ergosterol biosynthesis. Taken together, these results demonstrate the complex nature of germination and two genes important in the process ...
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