There are currently no human or mouse genes associated with this disease in the MGI database. Synonyms: ENFL2; nocturnal frontal lobe epilepsy 2

Old drugs, new tricks. Early promising anecdotal reports of treatment success using quinidine in drug-resistant epilepsy of infancy with migrating focal seizures caused by potassium channel gene KCNT1 gain-of-function mutations have been followed by mixed results from other investigators. And a small randomized trial of oral quinidine in patients with severe autosomal dominant nocturnal frontal lobe epilepsy due to KCNT1 mutations proved negative (Neurology. 2018 Jan 2;90(1):e67-e72. doi: 10.1212/WNL.0000000000004769. Epub 2017 Dec 1). An international group of investigators have asserted on the basis of an initial 15-patient series that the sodium-channel blockers carbamazepine and phenytoin should be considered first-line therapy in patients with KCNQ2 encephalopathy. They argued that early recognition and treatment of the disorder may be key to reducing the associated neurodevelopmental impairment (Epilepsia. 2015 May;56[5]:685-91). Time to reconceptualize epilepsy?. These potential new uses ...

Summary is not available for the mouse gene. This summary is for the human ortholog.] Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009 ...

Mutation Detection. We routinely amplified the transmembrane domains TM1, TM2, and TM3 of CHRNA4 and CHRNB2 by polymerase chain reaction (PCR) in ADNFLE patients using the following primers. CHRNA4: forward, 5′-TCACCTATGCCTTCGTCATC-3′; reverse, 5′-TGGCACGATGTCCAGGAAGA-3′, and CHRNB2: forward. 5′-TTCACACCTAGTGGTGAGTG-3′; reverse. 5′-TGGCTGCTGCATGAAGAGCA-3′. The PCR products were directly sequenced by BigDye Terminator ready-reaction kit (Applied Biosystems, Adelaide, Australia).. Mutation Constructs. We introduced in the CHRNB2 mutations for the β2 subunit (Monteggia et al., 1995) using the PCR-derived strategy described by Nelson and Long (1989). For β2-V287M and β2-L301V, the mutated fragment was ligated, after enzymatic digestion, at the unique NheI and PmlI restriction sites to the complementary wild-type CHRNB2 cDNA. The β2-V308A mutation was PCR-engineered from CHRNB2 cDNA and cloned into the pRC/CMV vector (Invitrogen, Basel, Switzerland). Two overlapping PCR products ...

Template:Infobox medical condition/Wikidata Frontal lobe epilepsy, or FLE, is a neurological disorder that is characterized by brief, recurring seizures that arise in the frontal lobes of the brain, often while the patient is sleeping. It is the second most common type of epilepsy after temporal lobe epilepsy (TLE), and is related to the temporal form by the fact that both forms are characterized by the occurrence of partial (focal) seizures. Partial seizures occurring in the frontal lobes can occur in one of two different forms: either simple partial seizures (that do not affect awareness or memory) or complex partial seizures (that affect awareness or memory either before, during or after a seizure). The symptoms and clinical manifestations of frontal lobe epilepsy can differ depending on which specific area of the frontal lobe is affected.[1]. The onset of a seizure may be hard to detect since the frontal lobes contain and regulate many structures and functions about which relatively little ...

We describe the case of a 33-year-old man with complex partial seizures characterized by the feeling of being projected outside his body, including dissociation of mind and self from body (disembodiment), followed by vestibular vertigo due to right frontal lobe epilepsy caused by an oligodendroglioma. We distinguish the patients ictal symptoms with respect to autoscopic phenomena (out-of-body experience, heautoscopy, autoscopic hallucinations) and vestibular phenomena of epileptic origin, and we discuss their neural origin with respect to vestibular and multisensory cortical mechanisms of bodily self-consciousness in temporoparietal and frontal cortex. Lopez, Christophe; Heydrich, Lukas; Seeck, Margitta; Blanke, Olaf

Frontal lobe epilepsy (FLE) surgery is the second most likely pharmacoresistant focal epilepsy benefitting from surgical treatment secondary to tempor..

DIFFERENTIAL DIAGNOSIS OF EPILEPTIC SEIZURES IN CRYPTOGENIC FOCAL FRONTAL LOBE EPILEPSY VERSUS PSYCHOGENIC NON-EPILEPTIC PAROXYSMS (A CASE REPORT)

Moguilner, S., Birba, A., Fino, D., Isoardi, R., Huetagoyena, C., Otoya, R., Tirapu, V., Cremaschi, F., Sedeño, L., Ibáñez, A., & García, A. M. (2021). Multimodal neurocognitive markers of frontal lobe epilepsy: Insights from ecological text processing. NeuroImage 235, 117998. doi: https://doi.org/10.1016/j.neuroimage.2021.117998 09 de abril 2021 En este estudio empleamos nuestra tarea validada de procesamiento de narrativas de acción para detectar marcadores específicos de pacientes con epilepsia del lóbulo frontal (ELF), en comparación con personas sanas y pacientes con epilepsias posteriores (EP). Los pacientes con ELF mostraron déficits selectivos y específicos en la aprehensión de acciones, asociados a alteraciones estructurales y funcionales en redes cerebrales motoras. Estas anomalías, en conjunto, permitieron identificar a pacientes con ELF de los participantes de los otros dos grupos con un 75% de precisión. Tales resultados sugieren que una tarea lingüística naturalista,

Mesial frontal lobe epilepsy: Seizures with a motor, or movement, component indicate damage or malformation in the area of the brain that controls movement.

TY - THES. T1 - Imaging the brain : neuronal correlates of cognitive impairment in children with frontal lobe epilepsy. AU - Braakman, HM. PY - 2013/1/1. Y1 - 2013/1/1. M3 - Doctoral Thesis. SN - 9789090274942. PB - Maastricht University. CY - Maastricht. ER - ...

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012 ...

Nicotine is a naturally occurring substance found in plants, similar to caffeine in coffee beans and tea leaves. There are high levels of nicotine in aubergines, potatoes, tomatoes and cauliflower.. It has a stimulant effect which promotes alertness, relaxation and a sense of calm. Because nicotine also reduces a persons appetite doctors are looking at it as a method to combat obesity.. Medical research has shown nicotine to prevent a range of ailments including Kaposis sarcoma, bowel ulcers, preeclampsia and allergic asthma. Research is currently looking at using nicotine to prevent and treat Alzheimers disease, delay the onset of Parkinsons disease and help adults suffering from nocturnal frontal lobe epilepsy seizures. Nicotine can be an effective treatment of depression and is undergoing clinical trials to help adults with acute OCD.. Nicotine is a toxin, a poison when taken in excess, which means that it has the potential to hurt small children and pets. Ensure that you store bottles of ...

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Objectives: The aimwas to describe the contribution of basal ganglia (BG) thalamo-cortical circuitry to thewholebrain functional connectivity in focal epilepsies. Methods: Interictal resting-state fMRI recordings were acquired in 46 persons with focal epilepsies. Of these 46, 22 had temporal lobe epilepsy: 9 left temporal (LTLE), 13 right temporal (RTLE); 15 had frontal lobe epilepsy (FLE); and 9 had parietal/ occipital lobe epilepsy (POLE). There were 20 healthy controls. The completeweighted networkwas analyzed based on correlation matrices of 90 and 194 regions. The network topologywas quantified on a global and regional level by measures based on graph theory, and connection-level changes were analyzed by the partial least square method. Results: In all patient groups except RTLE, the shift of the functional network topology away from random was observed (normalized clustering coefficient and characteristic path length were higher in patient groups than in controls). Links contributing to ...

In this common form of epilepsy, the seizures stem from the front of the brain. They can produce symptoms that appear to be psychiatric.

Ictal asystole is a presumably rare but potentially fatal complication of seizures, most often of temporal lobe origin. It is believed that at least some cases of sudden unexplained death in epilepsy (SUDEP) might be triggered by ictal bradycardia or asystole. Current standard practice is to implant a permanent pacemaker in these patients to prevent syncope and/or death. However, emerging data suggests that effective medical or surgical treatment of epilepsy might be enough to prevent cardiac asystole, eliminating the need for permanent pacemaker placement. We describe a case of new onset left frontal lobe epilepsy in a young athletic patient who presented with near-syncopal episodes but whose comprehensive work-up revealed frequent events of ictal bradycardia and asystole. He responded well to monotherapy using oxcarbazepine, avoiding a permanent pacemaker.

TY - JOUR. T1 - Theory of mind and epilepsy. T2 - What clinical implications?. AU - Giovagnoli, Anna Rita. AU - Parente, Annalisa. AU - Villani, Flavio. AU - Franceschetti, Silvana. AU - Spreafico, Roberto. PY - 2013/9. Y1 - 2013/9. N2 - Purpose Epilepsy can impair theory of mind (ToM), but the clinical significance of such a deficit is unknown. This study evaluated the influence of selective ToM deficits on self-appraisal, coping, and quality of life (QoL) in patients with focal epilepsy. Methods Data were collected from 66 patients with temporal or frontal lobe epilepsy, and from 42 healthy controls. The Faux Pas Task (FPT), Multiple Ability Self-report Questionnaire (MASQ), Coping Responses Inventory-Adult (CRI-Adult), and World Health Organization QoL 100 (WHOQoL 100) evaluated ToM, self-rated cognitive abilities, coping to stressful events, and QoL. Different tests and inventories assessed other cognitive functions, depression, and anxiety. Key Findings Patients were impaired in the ...

My name is Aileen Doyle and I have Epilepsy. The type of epilepsy I have is Frontal Lobe Epilepsy. I first showed symptoms when I was 4 and half years old. My mum says I was eating breakfast with my family when my older brother shouted Whats the matter with Aileen? My mouth was twitching to the side. At first my mother wasnt sure anything was wrong, but a couple of weeks later I had a full tonic-clonic seizure upstairs.. My mother immediately took me to the doctor who referred me to a doctor at Waterford Regional Hospital. There I was put on the drug Tegretol liquid. Then my mother asked for a referral to see a specialist in Crumlin Childrens Hospital. The name of the specialist that I was referred to there was Dr. McMenamin. During the next few years while I was in National School I was well controlled on the Tegretol and I saw Dr. McMenamin once a year.. When I was about 10, I was admitted to Crumlin for monitoring as my seizures were becoming more frequent. The seizures became hard to ...

Kincaid, D.M. & Trautman, N. Remembering: Teaching Students How to Retain and Mentally Manipulate Information. Chapter in Meltzer, L. (2010) Promoting Executive Function in the Classroom. The Guildford Press, New York. *Hernandez, M. (2003) Attention, memory and behavioural adjustment in children with frontal lobe epilepsy. Epilepsy and Behaviour 4(5), 552-536 ...

The girl presented a complex series of disturbances consisting of mild ID, marked delayed speech, minor facial features, circumscribed hypertrichosis, migraine with aura and epileptic seizures of NFLE type. In this girl, the clinical course of the epileptic seizures was favourable with good response to antiepileptic treatment, although at a recent assessment, the girl still complains of episodes of migraine with aura. aCGH analysis revealed in the girl a de novo deletion at 15q13.2-13.3 (chr.15: 30,938,215-32,914,081; hg19) with some of critical genes (FAN1, MTMR10, TRPM1, KLF13, OTUD7A, CHRNA7, and GOLGA8O) involved in many neurological features associated to the microdel15q13.3 syndrome (Fig. 1).8,13 Aside from the leading candidate of CHRNA7 gene in neurodevelopmental, neuropsychiatric and epilepsy disorders,1,6,14 it was interesting to find new potential connections of the genomic content to the clinical phenotype showed by the proband. Analyzing potential genotype-phenotype correlations, ...

TY - JOUR. T1 - Facial Expression of Emotion in Human Frontal and Temporal Lobe Epileptic Seizures. AU - Tassinari, Carlo Alberto. AU - Gardella, Elena. AU - Rubboli, Guido. AU - Meletti, Stefano. AU - Volpi, Lilia. AU - Costa, Marco. AU - Ricci-Bitti, Pio Enrico. PY - 2003. Y1 - 2003. KW - Emotion. KW - Facial expression. KW - Frontal lobe epilepsy. KW - Temporal lobe epilepsy. UR - http://www.scopus.com/inward/record.url?scp=1342305610&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=1342305610&partnerID=8YFLogxK. U2 - 10.1196/annals.1280.038. DO - 10.1196/annals.1280.038. M3 - Article. C2 - 14766654. AN - SCOPUS:1342305610. VL - 1000. SP - 393. EP - 394. JO - Annals of the New York Academy of Sciences. JF - Annals of the New York Academy of Sciences. SN - 0077-8923. ER - ...

There are a number of common misconceptions surrounding epilepsy and people often think of it as a mental disorder. In fact, it is a physical neurological condition that does not affect the persons day-to-day mental abilities.. Epileptic seizures are triggered by a sudden interruption in the brains highly complex electro-chemical activity.. Frontal lobe epilepsy is a where seizures can commonly happen during periods of non rapid eye movement sleep as well as during the day.. They often happen in clusters with many happening close together in time but are usually brief.. They can include sudden jerking movements, strange postures or movements of the arms or legs, loud cries or screams and wandering about during sleep. Who gets it?. A further one person in every 50 could develop epilepsy, and one in 20 will experience an epileptic seizure without actually developing the condition. Four times more people die from sudden unexpected death in epilepsy (SUDEP) every year than from Aids.. Although ...

Pubblicazioni recenti (dal 2005). - Ohayon MM, Ferini-Strambi L, Plazzi G, et al.. Frequency of narcolepsy symptoms and other sleep disorders in narcoleptic patients and their first-degree relatives. J Sleep Res. 2005;14(4):437-45.. -Zucconi M, Manconi M, Bizzozero D, Rundo F, Stam CJ, Ferini-Strambi L, Ferri R.. EEG synchronisation during sleep-related epileptic seizures as a new tool to discriminate confusional arousals from paroxysmal arousals: preliminary findings. Neurol Sci. 2005; 26 Suppl 3:s199-204.. - Ferini-Strambi L, Fantini ML, Zucconi M, et al.. REM sleep behaviour disorder. Neurol Sci. 2005; 26 Suppl 3:s186-92.. - Ohayon MM, Ferini-Strambi L, Plazzi G, et al.. How age influences the expression of narcolepsy. J Psychosom Res. 2005;59(6):399-405.. - Bruni O, Ferini-Strambi L, Russo PM, et al.. Sleep disturbances and teacher ratings of school achievement and temperament in children. Sleep Med. 2006;7(1):43-8.. - Combi R, Dalprà L, Ferini-Strambi L, Tenchini ML.. Frontal lobe epilepsy ...

Dogs, particularly those that are all or part German Shepherd and between the ages of one and one-half and four years of age may suddenly and violently attack a portion of their body as if it itched severely. The most commonly affected area is the end of the tail, but sometimes a paw is affected. These are generally high-strung dogs with other neurological problems (like tail chasing or fly snapping). This problem has been called self-mutilation syndrome. It may be a form of seizure similar to frontal lobe epilepsy. I have not observed this problem in horses. When it does occur in horses, it is thought to be an obsessive-compulsive behavior trait. Some of these dogs and horses will respond to antiseizue medications (Phenobarbital, Primidone, Dylantin). Other cases respond well to the tricyclic antidepressant, chlomipramine (Clomacalm) and antidepressant, amyltriptiline (Elavil). Prozac is also effective in some dogs. Although Phenobarbital and Primidone are often effective, long-term use of ...

Injury to the frontal lobes or interruptions of subcortical connections with the frontal lobe impair the functions of the frontal lobes, and some of these deficits of frontal lobe function are called executive deficits. Several studies suggest that frontal lobe dysfunction is often associated with aging. For example, Mittenberg, Seidenberg, OLeary, and DiGiulio (1989) compared older and younger individuals on tests that assessed frontal, parietal, and temporal lobe functions. These investigators found that it was frontal lobe function that best correlated with age.. Some of the most common executive deficits associated with frontal lobe dysfunction are forms of perseverative behavior. One of the tests that patients with frontal lobe perform poorly is the Wisconsin Card Sorting Test. In this test there are a series of cards that have different geometric designs, and these geometric designs have different colors and a different number of designs on each card. The participants are asked to sort ...

Examination of the current literature concerning the frontal lobes reveals an almost universal belief that surgical removals from this area must produce serious psychologic defects. The evidence on which the belief is founded, however, is not nearly so satisfactory as one might suppose. In this paper I propose to review and evaluate the published reports which attempt to analyze the functions of the frontal lobes on the basis of neurosurgical material. In the review, emphasis is laid on problems of method which are common to any such analysis, whatever region of the brain may be concerned. The occasion for a reevaluation of theories concerned with the frontal lobes was a fortunate opportunity to observe the social adjustment of K. M., a patient of Dr. Wilder Penfields, six years after a partial bilateral frontal lobectomy (Hebb and Penfield, 1 1940). The patients excellent recovery showed that a large bilateral removal is

We explain Cerebral Cortex: Frontal Lobes with video tutorials and quizzes, using our Many Ways(TM) approach from multiple teachers.|p|This lesson will identify, describe and differentiate the primary motor cortex, prefrontal cortex, and association areas of the frontal lobe. The functions and problems that may be associated with the frontal lobes will be discussed. The contribution of Phineas Gages accident to the field of psychology will be explored.|/p|

A frontal lobe stroke can cause a number of neurological deficits because the frontal lobe, a large part of the brain, has several important functions.

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THE BOSS BABY @ The Historic Howell Theater! Fri, Mar 31, 2017 - Sun, Apr 9, 2017 Sponsored by: Frontal Lobe Coworking Showtimes: March 31 4:15pm …. ...

What is frontal lobe ? The frontal lobe is a part of the brain that is present in humans and mammals. It is situated anterior to both cerebral hemispheres; above and in front of the ...

This area of the brain is associated with higher cognitive processes such as decision-making, reasoning, social cognition, and planning, as well as motor control. ...

Our brain is the HQ of our body, and when it does not function properly, nothing does. Although the human body will deteriorate, the brain never needs to deteriorate. Whatever we do to our body, it effects our brain. Lets find out how to keep it working and functioning until the day we die.

What is frontal lobe ? The frontal lobe is a part of the brain that is present in humans and mammals. It is situated anterior to both cerebral hemispheres; above and in front of the ...

Functions Of The Frontal Lobe In The Last Five Years? Discuss Essay, Research Paper The frontal lobe is thought to be the latest area of the brain to develop and is largest in humans. It is therefore suggested that the

Plot: A hilariously universal story about how a new babys arrival impacts a family, told from the point of view of a delightfully unreliable narrator, a wildly imaginative 7 year old named Tim.. ...

Still undaunted, I went on; a cut, here a slice there I really felt like I could do this. After my general research I decided it was time to concentrate on the brain. Here to I found there were various manners in which to proceed depending on the reason for the procedure. So I thought it was time to ask, what the specific reason for the operation was. Turns out it was to change the behavior and expectations of the patient. This helped a lot because now I knew I was to operate on the frontal lobe. So, based on my reading, I would have to remove a large section of the front of the scull. Well, with my new found knowledge and vicarious experience I was ready to move forward. I assembled an expert team of other non-medical personal who just happened to be really, really bright and set about to perform the surgery ...

TY - JOUR. T1 - Perspectives on the Developmental Consequences of Early Frontal Lobe Damage. T2 - Introduction. AU - Eslinger, Paul J.. AU - Grattan, Lynn M.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - The frontal lobes have been ascribed many of the psychological processes that underlie the highest forms of human adaptation and achievement. In most modern theories, frontal neural systems are the pivotal mediators of acculturation and social conduct, flexibility of thought and action, adaptive behavior, and goal attainment. Yet, despite this celebrated role in complex human behavior, the frontal lobes can sustain damage early in life that appears to have little impact on the organism, at least in terms of standard neuropsychologic and neurologic examinations. Hebb (1949) characterized the paradox this way.. AB - The frontal lobes have been ascribed many of the psychological processes that underlie the highest forms of human adaptation and achievement. In most modern theories, frontal neural systems are ...

Common effects of damage to the frontal lobe are varied. Patients who have experienced frontal lobe trauma may know the appropriate response to a situation but display inappropriate responses to those same situations in real life. Similarly, emotions that are felt may not be expressed in the face or voice. For example, someone who is feeling happy would not smile, and the voice would be devoid of emotion. Along the same lines, though, the person may also exhibit excessive, unwarranted displays of emotion. Depression is common in stroke patients. Also common is a loss of or decrease in motivation. Someone might not want to carry out normal daily activities and would not feel up to it.[7] Those who are close to the person who has experienced the damage may notice changes in behavior.[8] This personality change is characteristic of damage to the frontal lobe and was exemplified in the case of Phineas Gage. The frontal lobe is the same part of the brain that is responsible for executive ...

The course will provide an overview of acquired deficits following damage to the frontal lobes of the brain. Evidence predominantly from neurological patients but also functional neuroimaging of healthy individuals will be related where possible. Specific areas include disorders of attention, executive function, memory and social cognition that arise after lesions in specific regions of the frontal lobes. Different theoretical views of frontal lobe function will also be discussed such as the supervisory system model and the somatic marker hypothesis ...

Question - What does solitary tiny focus of subcortical hyperintensity within the left frontal lobe mean?. Ask a Doctor about when and why MRI is advised, Ask a Neurologist

Study Flashcards On Flashcards Due 10/21/06 (Frontal lobes, memory) at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!

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Hello, my mother in law was diagnosed officially in 2018 but presented classic symptoms associated with FTD for at least 5 years before. She has been in a...

So, Travis and Casey, here we are. One of you in the middle of college, one of you just starting Middle School. You like each other. You like us. You like life. This is more than I ever could have prayed for. You are what keeps me going when I am exhausted and beaten down by the things around me. You are what I think of when I put restraints on an angry teenager hammered out of his mind. You are what I think of when I care for the suicidal 14 year old with cutter lines road mapping her arm. I dont know how they got to the place theyre in, and I am not blind to the fact that it could happen to me, which is why I never stop trying my best for you. You are my refuge from the sorrow in this world. If every kid out there were shown the feelings we have for you, the world might be less despondent. To that end I challenge you to be a friend to someone who may not be a part of your circle. Show kindness to someone who doesnt normally get to experience it. You are smart enough to know what works, and ...

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Brief Answer: Depressive stress storm Detailed Answer: Hi, Thanks for being on healthcaremagic.com. I am Dr.Ajay Panwar,a neurologist, here to answer your query. I think you are talking about a Depressive stress storm .In the same, one may have a sudden offset of emotions, may not feel love or...

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience ...

Stillness + Inner Absorption = Transcendence - every time! This formula underlies all spiritual experience-and anyone can put it to use. No matter what teachings you are drawn to you will find meditation or intensive prayer at the heart. Learn to become ever more still, ever more absorbed, and you will find your heart-mind awareness gradually expanded, uplifted, transformed-and ultimately transcendent.. ...

A toolkit of backward self-therapy to release inhibitors blocking forward self-circuiting into dormant frontal lobes, transcendence into egolessness and finished maturation of whole brain power in the Lifeforce.

A toolkit of backward self-therapy to release inhibitors blocking forward self-circuiting into dormant frontal lobes, transcendence into egolessness and finished maturation of whole brain power in the Lifeforce.

Treat yourself to a frontal lobe feast thatll leave you feeling just a little bit smarter. If youre still hungry for more facts, check out these awesome knowledge nuggets.