Abstract Regarding efficacy of new antiepileptic drugs (AEDs) for seizure control, there are three important clinical questions.Download and Read New Antiepileptic Drugs Epilepsy Research Supplement No 3 New Antiepileptic Drugs Epilepsy Research Supplement No 3 It sounds good when knowing the.Several studies show drugs used to treat AEDS reduce bone density, increase risk of fracture, especially for the up to 50% of users unresponsive to AEDS.Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy. new AEDs with many of the non-AED drugs.AMR has developed set of analyst tools and data models to supplement.. Research identifies protein that could help patients respond more positively to epilepsy drug therapies.Seizures and epilepsy: Hope through research. for treatment of drug-resistant epilepsy ...
TY - JOUR. T1 - Understanding of and attitudes toward epilepsy among the urban Chinese population in Malaysia. AU - Hasan, S. S.. AU - Alen, Y. K S. AU - Wayne, W. G W. AU - Ahmadi, K.. AU - Anwar, M.. AU - Goh, G. K.. PY - 2010/4. Y1 - 2010/4. N2 - Introduction: People with epilepsy are socially discriminated against on the grounds of widespread negative public attitudes, misunderstandings and defensive behaviour. The primary purpose of this study was to evaluate the public understanding of and attitudes toward epilepsy among the Chinese population in Malaysia. Methods: A validated, self-administered questionnaire comprising 23 questions was utilised to evaluate the understanding of and attitudes toward epilepsy among randomly approached respondents from the Chinese population living in the urban areas of Penang, Klang Valley, Kuala Lumpur and Sibu in Malaysia. Results: Out of 1,000 people approached, 697 (69.7 percent) respondents agreed to participate in the study. When asked whether people ...
The Yale Epilepsy Research Retreat is a two day educational meeting in which clinical and basic science researchers from Yale and collaborators from other institutions will discuss the latest advances in cutting-edge epilepsy research. In addition, we are inviting an outstanding leader in epilepsy research, well versed in both human and basic epilepsy research, to speak at the Retreat, provide feedback and guidance, and serve as an external moderator and reviewer for the research program. The Retreat will consist of investigator slide presentations, poster sessions, and break-out discussions on new research approaches and collaborations. The Third Annual Yale comprehensive Epilepsy Research Retreat took place on April 3-4, 2014 at the Madison Beach Hotel in Madison, CT. The 2014 Research Retreat Agenda ...
Epilepsy is a common disease of the brain, occurring in roughly 1% of all people, and although repeated epileptic seizures are its clinical hallmark, epilepsy is not just a medical phenomenon, but a social construct, with cultural, political, and financial consequences. People with epilepsy are exposed to stigma and burdened with disadvantages which can be far reaching. There are indeed many remedies, but no cure. This book provides a biography of modern epilepsy in the form of a brief and selective narrative of some of the important developments in medical and social epilepsy research, with its many ups and downs, over the period since 1860. Its anatomy of modern epilepsy in eight chapters is, inevitably in this short book, selective, and intentionally provocative. The books main objective is to provide both a survey of the evolution of epilepsy and its treatment in the post-Jacksonian era, and also a critical look at where we are today and how we got there. This book tries to make an effort to
In Kentucky and Southern Indiana alone, more than 90,000 people have epilepsy, demonstrating a vital need for a comprehensive epilepsy team.. Epilepsy is the third-most common neurological disorder in the United States after Alzheimers disease and stroke. Between 30 percent and 40 percent of the 2.7 million Americans diagnosed with a seizure disorder have seizures that are not well controlled by medication. Others have their epilepsy untreated or misdiagnosed.. That is why the University of Louisville Hospital Epilepsy Center is such a critical resource for our community and state. Our center is one of only a few Level IV Epilepsy Centers in the region, meaning we have the ability to do everything from diagnosing epilepsy to performing surgery when appropriate.. Our Epilepsy Center has a state-of-the-art monitoring unit and dedicated nurses and physicians who have the experience and expertise needed to provide comprehensive epilepsy services.. ...
TY - JOUR. T1 - Classifications and epidemiologic considerations of epileptic seizures and epilepsy. AU - So, E. L.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - Epileptic disorders are some of the most common neurologic conditions. The lifetime risk of experiencing an epileptic seizure is as high as 8%. The manifestations of epileptic disorders are also quite protean. Clinical evaluation of seizure disorders requires a clear understanding of the classifications and the terminology used. This article defines and classifies epileptic seizures, epilepsy, and epilepsy syndromes. The epidemiologic profiles of first unprovoked seizure and epilepsy are also described.. AB - Epileptic disorders are some of the most common neurologic conditions. The lifetime risk of experiencing an epileptic seizure is as high as 8%. The manifestations of epileptic disorders are also quite protean. Clinical evaluation of seizure disorders requires a clear understanding of the classifications and the terminology used. This article ...
Since the development of the 2007 Epilepsy Research Benchmarks, remarkable strides have been made toward understanding the causes of epilepsy and epileptogenesis, developing new and improved treatments, and delineating factors that contribute to comorbidities associated with epilepsy. The Epilepsy Research Benchmarks Stewards have selected the following research advances from
New Hanover Regional Medical Center was recently accredited by the National Association of Epilepsy Centers as a level 3 epilepsy center. Level 3 epilepsy centers have the professional expertise and facilities to provide the highest level medical evaluation and treatment for patients with complex epilepsy.. A level 3 center provides the basic range of medical, neuropsychological, and psychosocial services needed to treat patients with refractory epilepsy. Level 3 epilepsy centers provide basic neurodiagnostic evaluations, as well as basic medical, neuropsychological, and psychosocial services. Some level 3 centers offer noninvasive evaluation for epilepsy surgery, straight-forward resective epilepsy surgery, and implantation of the vagus nerve stimulator. These centers do not perform intracranial evaluations or other more complex epilepsy surgery.. ...
Release: Nov. 13, 2000. UI Health Care specialist to lead online chat on epilepsy Nov. 14. IOWA CITY, Iowa -- Mark A. Granner, M.D., an associate professor of clinical neurology and director of the epilepsy monitoring unit with University of Iowa Health Care, will lead an hour-long, online question-and-answer discussion on epilepsy with a nationwide audience from 3:30 to 4:30 p.m. Tuesday, Nov.14.. The online chat will be hosted by AmericasDoctor.com and can be accessed by entering through the www.AmericasDoctor.com home page under Upcoming Events.. Epilepsy is the second most common neurological condition after migraine. Today, epilepsy can in most cases be controlled with the correct medical treatment. However, living with epilepsy has its problems, and special education and care are required for the person with epilepsy to lead an active, healthy, and satisfying life. Granner will discuss selected medical and social issues related with epilepsy and will answer questions from the ...
Most people with epilepsy CAN DO the same things that people without epilepsy can do. However, some people with frequent seizures may not be able to work, drive, or may have problems in other parts of their life.. * People with epilepsy CAN handle jobs with responsibility and stress. People with seizure disorders are found in all walks of life. They may work in business, government, the arts and all sorts of professions. If stress bothers their seizures, they may need to learn ways to manage stress at work. But everyone needs to learn how to cope with stress! There may be some types of jobs that people with epilepsy cant do because of possible safety problems. Otherwise, having epilepsy should not affect the type of job or responsibility that a person has.. * Even with todays medication, epilepsy CANNOT be cured. Epilepsy is a chronic medical problem that for many people can be successfully treated. Unfortunately, treatment doesnt work for everyone. AT LEAST 1 million people in the United ...
Patients living with epilepsy a complex seizure disorder face many challenges. Characterized by disabling seizures triggered by abnormal electrical activity in the brain cells, the disease can manifest itself through a range of symptoms, from minor physical signs and thought disturbances to traumatic physical convulsions. Several types of seizures are easy to control, and many patients are well enough between episodes to lead normal lives. However, about 30 percent of the estimated three million Americans with epilepsy suffer with persistent seizures.. In an outstanding validation of its commitment to improving the lives of patients with epilepsy, the NYU Winthrop Comprehensive Epilepsy Center has once again been recognized by the National Association of Epilepsy Centers (NAEC) as a Level 4 Epilepsy Center. Level 4 Epilepsy Centers have the professional expertise and facilities to provide the highest level medical and surgical evaluation and treatment for patients with complex epilepsy.. We at ...
Individuals with epilepsy who cannot be adequately controlled with anti-epileptic drugs, refractory epilepsy, may be suitable for surgical treatment following detailed assessment. This is a complex process and there are concerns over delays in referring refractory epilepsy patients for surgery and subsequent treatment. The aim of this study was to explore the different patient pathways, referral and surgical timeframes, and surgical and medical treatment options for refractory epilepsy patients referred to two Tertiary Epilepsy Clinics in New South Wales, Australia. Clinical records were reviewed for 50 patients attending the two clinics, in two large teaching hospitals (25 in Clinic 1; 25 in Clinic 2. A purpose-designed audit tool collected detailed aspects of outpatient consultations and treatment. Patients with refractory epilepsy with their first appointment in 2014 were reviewed for up to six visits until the end of 2016. Data collection included: patient demographics, type of epilepsy, drug
Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on...
of neuroimaging. Unlike congresses of thematic societies, the AMIE does not focus on results of examinations and studies but on the underlying technical aspects.. The AMIE is a twin-event with the Summer School on Imaging (SuSIE 2020) which provides clinical lectures and hands-on-workshops on Imaging in Epilepsy, Epilepsy Surgery, Epilepsy Research and Cognitive Neurosciences.. The AMIE 2020 was intended to take place from September 14th to 16th, 2020 in Bochum, Germany. However, due to the current COVID-situation, the AMIE 2020 will be held exclusively online. We offer the following program for you:. AMIE Online Scientific Workshops: all organizers of scientific workshops planned for the 2020 AMIE are currently being invited to run publically accessible video conferences instead. Look at the program to be updated with regards to those workshops that will go online and their respective time slots.. AMIE Sponsored Workshops: Commercial AMIE partners have the option to offer online presentations ...
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Epilepsy affects people of any age, gender, and race or ethnicity. Years of uncontrolled epilepsy can lead to cognitive decline or death, and increases the burden of epilepsy on society by reducing the likelihood that epilepsy patients will lead a productive, independent life. Fortunately, a randomized controlled trial has shown that focal epilepsy surgery is more effective and less costly than medical therapy and results in increased quality-of-life.. Unfortunately, there is the notion that epilepsy surgery is under utilized and the average time between onset of seizures and surgery is 20 years. Promoting utilization of epilepsy surgery is a way to improve patients quality of life by ensuring that they are receiving the best possible care. To achieve this goal, a user-friendly tool has been developed and validated to assist physicians in identifying patients ≥5 years old with focal epilepsy who should be referred for a surgical evaluation. For more information on how the tool was developed, ...
Speaking in the lead up to Purple Day for Epilepsy Awareness (Tuesday 26 March), geneticist Professor Jozef Gecz says advances in DNA sequencing have been a huge leap forward in understanding epilepsy.. This, combined with the use of stem cells in laboratory research, will lead to further advances in epilepsy treatment, he says.. However, he cautions that the same technology has also helped to reveal that epilepsy is a far more complex condition than previously thought.. Scientists used to believe that epilepsy was just one condition, possibly with one main cause. But now we know it is a very complex series of neurological disorders - it is many epilepsies, instead of just one epilepsy, with multiple causes and various symptoms, says Professor Gecz, from the University of Adelaides School of Paediatrics and Reproductive Health.. Epilepsy is common, with up to 3% of the Australian population experiencing epilepsy at some stage in their lives. Genetic and environmental factors, and trauma, can ...
Epilepsy is one of the most common neurological disorders and has enormous impact, both medical and social, for the individual as well as for the family. Treatments developed for epilepsy have largely been empirical rather than derived from knowledge of basic mechanisms, because the mechanisms underlying seizure occurrence and epileptogenesis are poorly understood. The Epilepsy Phenome/Genome Project (EPGP) is a large-scale, national, multi-institutional, collaborative research project aimed at advancing our understanding of the genetic basis of the most common forms of idiopathic and cryptogenic epilepsies and a subset of symptomatic epilepsy; i.e. epilepsies that are probably related to genetic predispositions or developmental anomalies rather than endogenous, acquired factors such as CNS infection, head trauma or stroke. The overall strategy of EPGP is to collect detailed, high quality phenotypic information on 3,750 epilepsy patients and 3,000 controls, and to use state-of-the-art genomic ...
Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy Immunomodulatory interventions for focal epilepsy syndromes Interventions for psychotic symptoms concomitant with epilepsy. Intravenous immunoglobulins for epilepsy. Ketogenic diet and other dietary treatments for epilepsy. Lamotrigine add-on for drug-resistant partial epilepsy. Lamotrigine adjunctive therapy for refractory generalized tonic-clonic seizures. Lamotrigine versus carbamazepine monotherapy for epilepsy. Levetiracetam add-on for drug-resistant focal epilepsy: an updated Cochrane Review. Losigamone add-on therapy for partial epilepsy. Melatonin as add-on treatment for epilepsy. Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the ...
Childhood Epilepsy Research, Professor Deb Pals Neuro Lab at Kings College London is a partnership of clinical and basic science researchers, parents and charities dedicated to finding the causes of childhood epilepsy.
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any pharmaceutical company, or any particular drug compound.Marinus Pharmaceuticals announced yesterday that their drug candidate, ganaxolone, developed for adults with drug-resistant focal onset epilepsy, did not ...
The Comprehensive Epilepsy Center at Childrens Mercy offers innovative treatment and support for children with seizure disorders and their families. We are recognized by the National Association of Epilepsy Centers as a Level 4 Center, the highest level in epileptic care. As one of only a dozen pediatric epilepsy centers in the nation, we are able to provide you with the most complete diagnostic and treatment services available.. Our EEG lab, which performs tests to evaluate and record brain wave patterns to detect potential problems, is ABRET certified. This means our technologists and facilities meet the highest standards for providing excellent quality EEGs every time. Fewer than 10% of labs across the country achieve this certification.. Whether youre looking for a diagnosis, a second opinion, or the latest research-supported treatment options, the Childrens Mercy Comprehensive Epilepsy Center team is here to help.. ...
The efforts of the International League against Epilepsy to devise classifications of the epilepsies has greatly improved communication among epileptologists and influenced both basic and clinical research. The efforts of the International League against Epilepsy (ILAE) to devise classifications of the epilepsies has greatly improved communication among epileptologists and influenced both basic and clinical research. Several classifications have been proposed since 1970; the most recent classification of epilepsy syndromes and epilepsies was published in 1989. Since 1997, the ILAE Task Force on Classification and Terminology has been evaluating this classification and some modifications have been recommended. Although the 1989 classification can be criticized and needs to be updated, it has been widely accepted and is universally employed. Consequently, the Task Force has agreed not to propose a replacement until a clearly better classification can be created.
Background: Neurocysticercosis is a major cause of epilepsy in developing countries and is endemic in Brazil. To test the hypothesis that the aetiological profile of patients with intractable epilepsy in Brazil includes neurocysticercosis, we conducted a cross sectional study investigating the aetiology of intractable epilepsy.. Methods: A total of 512 patients evaluated at the outpatient clinic for intractable epilepsy at the Ribeirão Preto School of Medicine were included in the survey. Medical intractability was determined on the basis of seizure incidence and severity, and response to appropriate epilepsy management. Neuroimaging included brain CT with non-contrasted and contrasted phases and high resolution MRI. Patients were divided into neurocysticercosis and non-neurocysticercosis groups according to previous diagnostic criteria.. Results: The most common epileptogenic lesions were mesial temporal sclerosis (MTS; 56.0%), malformations of cortical development (12.1%), and brain tumours ...
The Canadian Epilepsy Alliance Launches A New Epilepsy Comic Book As Part of BuskerFest Festival Activities. The Canadian Epilepsy Alliance (CEA) is thrilled to announce the launch of a new comic series designed to educate children about the most common neurological disorder in Canada, epilepsy. The Medikidz Explain Epilepsy comic series tells a fictional story based on the experiences of 14-year-old Jack, who is navigating middle school while living with epilepsy.. Despite the fact that epilepsy affects 1 in 100 Canadians, there is still so much misinformation and lack of awareness out there, says Gail Dempsey, President of the Canadian Epilepsy Alliance. Addressing the information gaps about epilepsy is key and by educating children in a fun way that resonates, like with the comic series, we can close that gap.. READ MORE. ...
This is a study to see if vitamin E helps children with epilepsy have fewer seizures. About 20-30% of children with epilepsy do not have adequate seizure control with established antiepileptic drugs (AEDs). Other options for patients with uncontrolled epilepsy are newer antiepileptic medications, ketogenic diet and surgery. However, a small percentage of patients are candidates for these options. Therefore, additional treatments are needed to improve seizure control in patients with uncontrolled epilepsy. Animal studies have shown an association between vitamin E supplementation and seizure reduction. A study in children also showed that vitamin E helped reduce seizures. However, a similar study in adults did not show a reduction in seizures with vitamin E supplementation. Therefore, this research study is being done to help define vitamin Es usefulness and safety as a treatment for epilepsy. Fifty patients will be recruited from the Childrens Epilepsy Program at The Childrens Hospital in ...
The Epilepsy Family Study of Columbia University (EFSCU) is a long-term study of ways in which genes contribute to epilepsy risk. One of our main goals is to identify genes that play a role in epilepsy. Knowledge about the genes associated with epilepsy could potentially be very important for early identification and treatment of epilepsy in susceptible individuals. Genetic information can also help researchers and physicians understand what causes epilepsy and lead to the development of new methods for treatment or prevention of the different epilepsy syndromes. Thanks to the many families and individuals that volunteered for our studies over the past twenty years, weve made a number of important discoveries. While we continue to search for genes associated with epilepsy, weve also done important work on other aspects of epilepsy genetics. For example, recent studies have explored the relationship between epilepsy and other disorders, such as migraines and depression. Weve also begun to ...
1. Benbadis SR, Tatum WO, Gieron M. Idiopathic generalized epilepsy and choice of antiepileptic drugs. Neurology 2003; 61(12): 1793-5. 2. Panayiotopoulos CP. Idiopathic Generalised Epilepsies. In: Panayiotopoulos CP, editor. The Epilepsies: Seizures, Syndromes and Management. Chipping Norton: Bladon Medical Publishing 2005: 271-339. 3. Duron RM, Medina MT, Martinez-Juarez IE, Bailey JN, Perez-Gosiengfiao KT, Ramos-Ramirez R et al. Seizures of idiopathic generalized epilepsies. Idiopathic generalized epilepsies recognized by the International League Against Epilepsy. Use and abuse of EEG in the diagnosis of idiopathic generalized epilepsies. Epilepsia 2005; 46(Suppl 9): 34-47. 4. Nordli DR, Jr. Idiopathic generalized epilepsies recognized by the International League Against Epilepsy. Epilepsia 2005; 46(Suppl 9): 48-56. 5. Ferner RE, Panayiotopoulos CP. Phantom typical absences, absence status and experiential phenomena. Seizure 1993; 2(3): 253-256. 6. Panayiotopoulos CP. Syndromes of idiopathic ...
Orrin Devinsky is Professor of Neurology, Neurosurgery, and Psychiatry at the NYU School of Medicine, where he directs the Epilepsy Center. He also directs the Saint Barnabas Institute of Neurology. His epilepsy research includes cannabidiol, autism, genetic epilepsies, sudden death in epilepsy (SUDEP), healthful behavioral changes, therapeutic electrical stimulation, quality-of-life, cognitive and behavioral issues, and surgical therapy. He is the Principal Investigator for the North American SUDEP Registry and for the SUDC Registry and Research Collaborative. He is on the Executive Committee of the SUDEP Institute and Scientific Advisory Boards of the Epilepsy Foundation, Dup15q Alliance, Tuberous Sclerosis Association, KCNQ2 Cure Alliance Foundation, and Chairs the Loulou Foundation CDKL5 Program of Excellence. He serves as the lead investigator for the Epidiolex Dravet and Lennox-Gastaut studies and the PTC Ataluren study in genetic epilepsies. He founded Finding A Cure for Epilepsy and ...
TY - JOUR. T1 - Brain glucose metabolism and its relation to amyloid load in middle-aged adults with childhood-onset epilepsy. AU - Joutsa, Juho. AU - Rinne, Juha O.. AU - Karrasch, Mira. AU - Hermann, Bruce. AU - Johansson, Jarkko. AU - Anttinen, Anu. AU - Eskola, Olli. AU - Helin, Semi. AU - Shinnar, Shlomo. AU - Sillanpää, Matti. PY - 2017. Y1 - 2017. U2 - 10.1016/j.eplepsyres.2017.09.006. DO - 10.1016/j.eplepsyres.2017.09.006. M3 - Artikel. VL - 137. SP - 69. EP - 72. JO - Epilepsy Research. JF - Epilepsy Research. SN - 0920-1211. ER - ...
Antiepileptic drugs (AEDs) were frequently used as polytherapy until evidence from a series of studies in the late 1970s and early 1980s suggested that patients derive as much benefit from monotherapy as polytherapy.1-3 AED polytherapy is increasingly becoming popular again and as much as 30-40% of prescriptions to children are polytherapy.4 ,5 The availability of new-generation AEDs in the last two decades has encouraged polytherapy. AEDs such as lamotrigine, topiramate, levetiracetam, oxcarbazepine and zonisamide have been approved for paediatric use and are recommended mostly as adjuncts or as second-line agents.6 Despite the availability of more AEDs, the prevalence of poorly controlled epilepsies still remains the same. About 30% of epilepsies are resistant to treatment.7 Drug-resistant epilepsies almost always require polytherapy, but the question of the best treatment approach when an initial monotherapy fails is still debatable. ...
Group Name: Epilepsy Toronto - Adults with Epilepsy Connection (AWE). Description: Epilepsy Toronto is a non-profit agency that has supported people living with epilepsy for over 50 years. They offer free PROGRAMS AND SERVICES, host exciting EVENTS throughout the year, and provide lots of epilepsy information as well. Whether you have epilepsy, know someone who lives with seizures, or are just an interested community member wanting to learn more, Epilepsy Toronto can help! If you are otherwise engaged during the day and is unable to take advantage of day-time activities at Epilepsy Toronto, then AWE Connection may be just what you need. Come be a part of a support group that provides you with the opportunity to connect with other adults living with epilepsy, learn more about epilepsy and share your feelings and concerns in a warm and supportive environment.. Where: 468 Queen St. East, Suite 210 , Toronto, ON M5A 1T7. When: Third Tuesday of every month, from 6 p.m. until 8 p.m.. Contact: Rosie ...
Register. Looking for a fun way to run and raise money to help find a cure for epilepsy? Join CURE Epilepsys virtual Run for Research from April 26 to May 2. Run 26.2 miles over the course of a one-week period for the 1 in 26 Americans living with epilepsy. Until we can run together in the fall, CURE Epilepsy Champions of all fitness levels will run independently to raise funds to find a cure.. Looking to run a marathon this October? CURE Epilepsy has secured 5 charity spots in the Bank of America Chicago Marathon being run on Sunday, October 10. Find out more about how you can join Team CURE Epilepsy.. Looking for a way to help spread awareness of the importance of epilepsy research and help fundraise at the same time? Become a CURE Epilepsy Champion. Learn more!. ...
EpiReg is a research- and quality registry and biobank for patients treated at Department of Neurology, Haukeland University Hospital. The aim of EpiReg is to use the collected information to increase quality and excellence in epilepsy treatment. We also use the information for research EpiReg is initated and maintained by Bergen Epilepsy Research Group (BERG). EpiReg was established in 2019 with funding from Helse Vest, later also from Helse Bergen. The regional ethical committee has approved it (REK 2018/586). The database is integrated with the hospital record system of the hospital so that all registered information is also visible in the patients individual hospital record. EpiReg was established in cooperation with Norsk Epilepsiforbund, the national patient organization, and it has continuous user support. EpiReg interacts with the national EpilepsiNett project supported by the Research Council of Norway. EpiReg collects both patient-reported data and medical information. The aim is to ...
We believe that no one with epilepsy should go it alone.. We Are Creating an Epilepsy Smart Australia. Research shows that, despite the conditions prevalence, ninety percent of Australians dont have access to the epilepsy support they need. In response, the Australian Government has funded the Epilepsy Foundation to take our work to a national scale through a new program titled Epilepsy Smart Australia. We are expanding our delivery of services that will reduce the chronic health impacts experienced by Australians of all ages living with epilepsy.. We Support People Living with Epilepsy. No one with epilepsy should go it alone. Every case of epilepsy is unique and everyone with epilepsy will need some form of support in their life. The Epilepsy Foundation works to ensure that:. ...
Overall mortality, incidence of sudden unexpected death, and cause of death were determined in 601 adult outpatients with epilepsy at a tertiary referral centre. The patients were followed up from 1990 to 30 June 1993. There were 24 deaths among the 601 patients (1849 patient years) with a standardised mortality ratio of 5.1 (95% confidence interval 3.3-7.6) of which 14 were related to epilepsy. Underlying disease of which epilepsy was a symptom accounted for four deaths only. An incidence of sudden deaths (including seizure related) was of the order of 1:200/year. In conclusion, excess mortality in chronic epilepsy is more likely to be related to the epilepsy itself than to underlying pathology. The relatively high incidence of sudden deaths found in this hospital based cohort has important implications for patient management.. ...
TY - BOOK. T1 - Models of Seizures and Epilepsy. T2 - Second Edition. AU - Pitkänen, Asla. AU - Buckmaster, Paul S.. AU - Galanopoulou, Aristea S.. AU - Moshé, Solomon L.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure. Offers insights on the use of novel technologies that can be applied in experimental ...
Scientists at Seattle Childrens Research Institute have found a way to rapidly suppress epilepsy in mouse models by manipulating a known genetic pathway using a cancer drug currently in human clinical trials for the treatment of brain and breast cancer.. The findings, reported in the journal eLIFE, open a new class of drugs to study for the treatment of intractable epilepsy, a severe form of epilepsy that does not respond to drugs. About 460,000 children have epilepsy in the United States, and about 20 percent of them have intractable epilepsy.. Intractable epilepsy is devastating because theres no way to control seizures in those patients, and some of them will undergo surgery to remove the brain tissue that causes the epilepsy, said Dr. Kathleen Millen, a researcher at the institutes Center for Integrative Brain Research and lead study author. We were able to stop seizures in mouse models within one hour of treatment using a drug that targets a genetic pathway linked to intractable ...
As a part of National Epilepsy Awareness Month, the Epilepsy Foundation (EF) launched the #AimForZero seizures campaign. A goal of this campaign is to reduce the risk of sudden unexpected death in epilepsy (SUDEP) through patient education. Talking about early death in epilepsy, particularly SUDEP, is hard, but it is important to let people know their risks.. Talking about SUDEP is a critical part of epilepsy care. Everyone should know what it is, and what it is now. Only by talking about it can people learn their risks and take action to improve seizure control, and ideally lessen their risks of SUDEP.. Invite your patients and their families to join the Epilepsy Foundation on Tuesday, November 14, 2017, 8 to 9 p.m. ET for a webinar on Talking About SUDEP. Dr. Daniel Friedman, epilepsy.coms SUDEP Editor, and Wendy Miller PhD, RN, CCRN of Indiana University, will discuss the latest thinking on SUDEP and the importance of talking about it and knowing your risks. Hear perspectives and tips from ...
There are approximately 250,000 people living with epilepsy in Australia and 65 million worldwide. Epilepsy and the unpredictably of the recurrent seizures can impact the independence and confidence of people living with the disease.. While many people effectively manage the condition with their first or second anti-epileptic drugs, if it fails to be treated the chance of responding to further drugs is significantly diminished, leaving about 30 percent of patients with drug resistant epilepsy.. This means many people are faced with few choices which allow them to effectively manage their debilitating condition. There are also legal restrictions that can impact their job prospects and independence, for example understandably preventing many with epilepsy from even holding a drivers license.. This grant will help the University to accelerate its work on a seizure advisory system for adult individuals diagnosed with epilepsy who want or used to drive a vehicle.. The system, NeuroSyd, aims at ...
BACKGROUND: There is little data on the burden or causes of epilepsy in developing countries, particularly in children living in sub-Saharan Africa. METHODS: We conducted two surveys to estimate the prevalence, incidence and risk factors of epilepsy in children in a rural district of Kenya. All children born between 1991 and 1995 were screened with a questionnaire in 2001 and 2003, and those with a positive response were then assessed for epilepsy by a clinician. Active epilepsy was defined as two or more unprovoked seizures with one in the last year. RESULTS: In the first survey 10,218 children were identified from a census, of whom 110 had epilepsy. The adjusted prevalence estimates of lifetime and active epilepsy were 41/1000 (95% CI: 31-51) and 11/1000 (95% CI: 5-15), respectively. Overall two-thirds of children had either generalized tonic-clonic and/or secondary generalized seizures. A positive history of febrile seizures (OR=3.01; 95% CI: 1.50-6.01) and family history of epilepsy (OR=2.55; 95% CI
Brigham and Womens Hospital is fortunate to have Page B. Pennell, MD, a noted researcher and leading authority on epilepsy and pregnancy. Dr. Pennell is the director of research for the Division of Epilepsy in the Department of Neurology. She oversees multi-center research collaborations on a wide breadth of epilepsy-related topics, from womens issues such as hormones, pregnancy and menopause to new epilepsy treatments and neuroimaging in surgical planning and treatment of epilepsy.. Before joining the BWH staff, she was an associate professor of Neurology and director of the Epilepsy Program at Emory University School of Medicine in Atlanta, Georgia.. Dr. Pennell has served on the editorial boards for the journals Epilepsia and The Neurologist. Dr. Pennell has also published over 50 papers in her field. She is a fellow in the American Neurological Association and a member of the American Epilepsy Society and American Academy of Neurology. In the American Epilepsy Society, she has served as ...
Profiling the Evolution of Depression After Epilepsy Surgery. the epilepsy cant be excluded as demanded by DSM-IV certainly. Exhaustion and psychomotor slowing are generally due to antiepileptic medicines (AEDs). Melancholy in epilepsy could be intermittent and of shorter length or merely linked to seizures in the preictal or postictal stage (6). Is it feasible that melancholy in epilepsy can be a different disease procedure altogether than main melancholy without epilepsy? Wrench and co-workers certainly attemptedto element in psychosocial elements that additional cloud the issue. In addition the influence of antiepileptic medications on depressive disorder cannot be ignored. AED differences on depressive disorder were not systematically examined in this study most likely due the variety of AEDs and the fact that all patients were taking AEDs. What is the true pathophysiologic Rabbit Polyclonal to MPHOSPH9. substrate of depressive disorder in epileptic patients? Is it the seizures the ...
Behavioral and related disorders are frequently reported in association with childhood epilepsy but the reasons for this are unclear. In a long-term prospective, community-based study of newly-diagnosed childhood epilepsy, behavioral assessments (Child Behavior Checklist) were performed in children 8 to 9 years after the initial diagnosis of epilepsy to determine the impact of remission and medication status on behavioral problems. Children with epilepsy were also compared with sibling controls. A total of 226 children (108 females, 118 males; mean age 13y 1mo [SD 2y 8mo], range 8-17y) with idiopathic or cryptogenic epilepsy were included in the analyses. One hundred and twenty-eight matched pairs were included in analyses of case-sibling differences. Lack of remission and current medication use were associated with worse behavioral problem and competency scores. Lack of remission generally had a greater effect than medication use, except for attention problems; medication status had the more
This survey identified key areas of improvement in terms of knowledge and development of specific skills for epileptologists regarding management of the psychiatric comorbidities of epilepsy. For the first time, psychiatrists were involved in the process and it was possible to identify specific needs for adult and child neurologists treating patients with epilepsy.. Epileptologists are keen to improve their clinical skills and screening during routine clinical practice seems to be the priority. Most adult neurologists feel inadequate or not skilled enough when dealing with patients with epilepsy and ASD, ADHD, or IDs in general. Child neurologists are historically better trained in these conditions and thus, usually more adept in their management. A prospective community-based study of children and adolescents with active epilepsy showed that up to 40% of patients have IDs, one third have ADHD, and around 20% have ASD (Reilly et al., 2014). In addition, a community-based survey of more than ...
Seizures eliminated in 48 percent of patients and QOL improved in 80 percent of patients according to 26-year follow-up. While epilepsy surgery is a safe and effective intervention for seizure control, medical therapy remains the more prominent treatment option for those with epilepsy. However, a new 26-year study reveals that following epilepsy surgery, nearly half of participants were free of disabling seizures and 80% reported better quality of life than before surgery. Findings from this study-the largest long-term study to date-are now available in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE).. More than 50 million individuals worldwide suffer from seizures caused by epilepsy according to a 2001 report by the World Health Organization (WHO). Medical evidence shows that compared with the general population, epilepsy patients have significantly poorer health-related quality of life, higher rates of co-morbidites, and lower ...
The European Forum on Epilepsy Research (ERF 2013) took place in Dublin from the 26th - 29th May 2013. Find out more at the IBE blog.
Background:. - Medically intractable epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures completely or almost completely in one-half to two-thirds of patients who qualify for surgery. The tests and surgery performed as part of this treatment are not experimental, but researchers are interested in training more neurologists and neurosurgeons in epilepsy surgery and care in order to better understand epilepsy and its treatment.. Objectives:. - To use surgery as a treatment for medically intractable epilepsy in children and adults.. Eligibility:. - Children and adults at least 8 years of age who have simple or complex partial seizures (seizures that come from one area of the brain) that have not responded to medication, and who are willing to have brain surgery to treat their medically intractable epilepsy.. Design:. ...
Over the time there has been great advancement in the field of epilepsy in terms of diagnosis and management of patients with epilepsy. But overall there is not much change in the classification of epilepsy and epileptic syndromes. The role of genetics is also increasing for definitive diagnosis of epilepsy, especially genetic epilepsy syndromes. Imaging has also improved immensely to delineate the lesion in a better way so that more and more patients can be operated to resect the seizure focus for control of epilepsy. Newly selective surgical techniques are being developed with minimal possible damage to the anatomy of the brain. Now epilepsy neurosurgeons care more to prevent postoperative gliosis which can later develop into seizure focus. The role of EMU is expanding for definitive diagnosis and management of epileptic patients. It has become an inevitable diagnostic tool for epileptic patients referred to a tertiary care centre for diagnosis and control of seizures and other paroxysmal ...
Siddhartha Nadkarni, MD, Director. Duration: 1-2 years. For candidates who have completed an ACGME-accredited neurology residency and an ACGME approved Clinical Neurophysiology or Epilepsy Fellowship. This is an Non-ACGME-accredited fellowship program. The educational purpose of the program is to primarily give fellows already trained in clinical neurophysiology or clinical epilepsy the opportunity to apply their knowledge to epilepsy research and obtain further training in scalp/ intracranial EEG, electrocorticography, cortical mapping, as well as clinical management of patients with epilepsy.. Contact:. Siddhartha Nadkarni, ...
The present study shows an association between shorter duration of epilepsy and better seizure outcome after resective epilepsy surgery in a systematic review and meta-analysis. The discussion about the importance of earlier epilepsy surgery has been around for a long time and motivated US researchers to initiate an ambitious RCT, ERSET, to determine whether surgery in patients with drug-resistant temporal lobe epilepsy soon after failure of 2 antiepileptic drug trials is superior to continued medical management.2 A sample size of 200 participants was originally planned, but the trial had to be terminated prematurely. Only 38 patients were recruited with a mean epilepsy duration of 10.9 years,2 which though it may seem rather long is much shorter than the mean epilepsy duration of 19.7 years in the first randomized controlled trial.1 Nevertheless, even in this limited cohort, resective surgery and antiepileptic drug treatment resulted in a lower probability of seizures during the second year of ...
Lacosamide vs Controlled-Release Carbamazepine Monotherapy as Initial Epilepsy Treatment. Information sourced from NEJM Journal Watch:. Lacosamide vs. Controlled-Release Carbamazepine Monotherapy as Initial Epilepsy Treatment. Lacosamide was no less effective for new-onset seizures in patients with clinically suspected partial epilepsy.. Nearly all new antiepilepsy medications (AEDs) obtain initial indications as adjunctive (add-on) therapy in patients with medically uncontrolled epilepsy, yet most patients are treated (or wish to be) with only one medicine. Very few head-to-head comparisons have been done between new AEDs and older medications with established efficacy in the largest generalizable populations: those with new-onset seizures or those that can be controlled with one AED. Lacosamide (LCM) is FDA-approved as monotherapy based on historical controls and is not approved as monotherapy in Europe. This large international, double-blind, randomized, manufacturer-sponsored study compared ...
TORONTO, ON (March 6, 2012) - Today at Queens Park, 40 members of Ontarios epilepsy community, led by Epilepsy Ontario and the Epilepsy Cure Initiative, gathered to meet with MPPs and policy advisors to increase awareness of epilepsy within government and advocate for the implementation of an Ontario Epilepsy Strategy. The key topics of discussion included the impact of epilepsy on Ontarians, consistent standards of patient care, improved access to treatment and disability and employment supports.. Recently, the Ontario Health Technology Advisory Committee released recommendations to improve access to and standardize epilepsy care in Ontario which we strongly support as the foundation for a provincial epilepsy strategy, said Rozalyn Werner-Arcé, Executive Director, Epilepsy Ontario. On behalf of Ontarians living with epilepsy, their families and employers, we ask the government to ensure it incorporates the key role of community epilepsy organizations in the implementation of this ...
TY - JOUR. T1 - Status epilepticus in a population-based cohort with childhood-onset epilepsy in Finland. AU - Sillanpää, Matti. AU - Shinnar, Shlomo. PY - 2002/9/1. Y1 - 2002/9/1. N2 - Little is known about the time course over which status epilepticus occurs in childhood-onset epilepsy and its impact on long-term prognosis. A population-based cohort of 150 children younger than age 16 years with new onset epilepsy between 1961 and 1964 residing in the catchment area of Turku University Hospital was observed prospectively until 1997. The occurrence of status epilepticus and recurrent status epilepticus, risk factors for status epilepticus, and the impact of status epilepticus on prognosis were examined. Of the 150 cases, 41 patients (27%) experienced an episode of status epilepticus of whom 22 patients (56%) had two or more episodes. The risk of status epilepticus was highest at the onset of the disorder with 30 (73%) cases occurring before (n = 12) or at (n = 18) onset and 37 (90%) cases ...
Epilepsy, also known as seizure disorder, is a common disease of the brain affecting about one percent of the population. It can affect any person at any age. More than 36,000 Mississippians live with epilepsy. Recognized as the states only level 4 epilepsy center accredited by the National Association of Epilepsy Centers, University of Mississippi Medical Center provides comprehensive testing and treatment for patients of all ages.University Comprehensive Epilepsy Center is dedicated to the care of people with epilepsy. The center offers state-of-the-art medical and surgical treatment of seizures/epilepsy in adults and children. Our goal is to help patients gain control of seizures and optimize their quality of life.Diagnosis, Treatment, and ReferralsA full complement of advanced diagnostic tests is available for seizures diagnosis, classification, and evaluation for surgical treatment of epilepsy. The centers inpatient epilepsy monitoring unit combines video and EEG monitoring of patients to
According to a recent study, children with Rolandic epilepsy should receive treatment in order to reduce their risk of cognitive and behavioural problems.BackgroundRolandic epilepsy is the most common form of childhood focal epilepsy syndrome, accounting for 15-20% of epilepsies in people aged b ...
Background: Treatment of pediatric epilepsy has advanced with the development of new antiepileptic drugs. The European Medicines Agency recommends that more research into pediatric drugs for epilepsy is needed.. Objectives: To characterize utilization of antiepileptic drugs in children with a specific emphasis on newer antiepileptic drugs.. Methods: Data were obtained from the German Pharmacoepidemiological Research Database for the period 2004-2006, including prescription data of more than 14 million insurance members from all over Germany. Descriptive analyses were perfomed to assess prevalence and incidence of antiepileptic drug use stratified by age and sex. Mono- and combination therapy were considered as well as the clinical speciality of the prescribing physician.. Results: We identified 13,197 children who received a total of 226,856 antiepileptic drug dispensations. Of these, 140,992 (62.15%) were conventional and 85,864 (37.85%) were newer antiepileptic drugs. Most commonly prescribed ...
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Aim. To study the efficacy of vagus nerve stimulation (VNS) therapy in a highly drug-resistant childhood epilepsy patient group and to investigate the effect of age at implantation on efficacy. Methods. The efficacy of VNS treatment was analysed in a cohort of 70 patients with drug-resistant epilepsy. Both children with focal (n=16) and generalized epilepsies (n=54) were included. Age at implantation varied between 19 months and 25 years. Results. Overall, responder rate was 54% with 5.7% children becoming seizure-free. The only factor in our analysis that could predict good outcome was age at implantation. In the youngest group ...
Get information on the types of pediatric epilepsy surgery and the symptoms, treatment, and causes of childhood epilepsy. Learn about epilepsy surgery recovery, side effects, and the procedure for epilepsy surgery. Discover the three main surgical types, including resective.
In this cohort of 519 patients, 60 (11.6%) had epileptic seizures associated with SLE disease activity. The frequency of epileptic seizures in previous studies ranged between 8.3 and 28%.1,5-10,21⇓⇓⇓⇓⇓⇓⇓ Epileptic seizures at disease onset were identified in 19 (31.7%) of these 60 patients. Epileptic seizures occurred after the onset of the disease in 41 (68.3%) patients. Fifty-three (88.3%) patients had a single epileptic seizure episode, and 7 (11.7%) had recurrent epileptic seizures. Generalized tonic-clonic and complex partial seizures were the most common epileptic seizures observed in this study. At disease onset, epileptic seizures were associated with stroke and the presence of moderate to higher titers of IgG antiphospholipid antibodies. The association between higher titers of antiphospholipid antibodies and seizures has been demonstrated previously.2,4,9,22-26⇓⇓⇓⇓⇓⇓⇓. Epileptic seizures may occur in isolation or accompany other neurologic ...
We provide info on our second election ask, which is to ensure there is at least one adult and one paediatric Epilepsy Specialist Nurse (ESN) in each health board.
article{6985217, abstract = {This study, supported by the Rwandan Ministry of Health and the World Health Organization, was conducted in 2005 to determine the prevalence of epilepsy and its sociocultural perception in Rwanda, as well as epilepsy-related knowledge and practices of health-care professionals (HCPs). A cross-sectional, nationally representative survey was conducted throughout Rwanda by trained investigators. Participants were recruited by random cluster sampling based on the organization of administrative units in the country. Overall, 1137 individuals (62% from rural areas) were interviewed. The prevalence of epilepsy was estimated to be 49 per 1000 people or 41 per 1000 for active epilepsy. Onset of epilepsy before the age of 2 years was reported in 32% of the cases. Family history of epilepsy, head trauma, and premature delivery were reported in 53%, 50%, and 68% of the cases, respectively. Most (68%) patients did not receive any medical treatment for epilepsy; 21.5% had received ...
1. Baxendale S. The representation of epilepsy in popular music. Epilepsy Behav. 2008; 12(1):165-169. 2. Tuft M, Nakken KO. Epilepsy and stigma in popular music. Tidsskr Nor Laegeforen. 2014;134:2290-3. 3. Kuscu DY, Kayrak N, Karasu A, Gul G, Kirbas D. Ictal singing due to left mesial temporal sclerosis. Epileptic Disord. 2008;10(2):173-6. 4. Barker AS, Bowen JR, Sharrack B, Sarrigiannis PG. Tap dancing in epilepsy. Epilepsy Behav. 2011;20(1):150-1. 5. Bagla R, Khoury JS, Skidmore C. Teaching Video NeuroImages: dancing epilepsy. Neurology. 2009; 72(22):e114. 6. Janz D. Epilepsy, viewed metaphysically: an interpretation of the biblical story of the epileptic boy and of Raphaels transfiguration. Epilepsia. 1986;27(4):316-22. 7. Mann MW. The epileptic seizure and the mystery of death in Christian painting. Epilepsy Behav. 2010; 17(2):139-46. ...
Purpose: The restricted genetic diversity and homogeneous molecular basis of Mendelian disorders in isolated founder populations have rarely been explored in epilepsy research. Our long-term goal is to explore the genetic basis of epilepsies in one such population, the Gypsies. The aim of this report is the clinical and genetic characterization of a Gypsy family with a partial epilepsy syndrome. Methods: Clinical information was collected using semistructured interviews with affected subjects and informants. At least one interictal electroencephalography (EEG) recording was performed for each patient and previous data obtained from records. Neuroimaging included structural magnetic resonance imaging (MRI). Linkage and haplotype analysis was performed using the Illumina IVb Linkage Panel, supplemented with highly informative microsatellites in linked regions and Affymetrix SNP 5.0 array data. Results: We observed an early-onset partial epilepsy syndrome with seizure semiology strongly suggestive ...
New research reveals a shared genetic susceptibility to epilepsy and migraine. Findings published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), indicate that having a strong family history of seizure disorders increases the chance of having migraine with aura (MA).. Medical evidence has established that migraine and epilepsy often co-occur in patients; this co-occurrence is called comorbidity. Previous studies have found that people with epilepsy are substantially more likely than the general population to have migraine headache. However, it is not clear whether that comorbidity results from a shared genetic cause.. Epilepsy and migraine are each individually influenced by genetic factors, explains lead author Dr. Melodie Winawer from Columbia University Medical Center in New York. Our study is the first to confirm a shared genetic susceptibility to epilepsy and migraine in a large population of patients with common forms of epilepsy.. For the present study, ...
The temporal lobe would be the part in red. Only the left temporal lobe is shown.. The temporal lobe is separated into 2 parts: right and left. Its responsible for auditory processing, processing of semantic & lexical information in speech, and long-term memory. On the other hand, epilepsy aka seizure disorder is a common neurological disorder that causes recurrent & unprovoked seizures in patients. These seizures happen when clusters of neurons fire excessively/abnormally/synchronously. Combine these two, and youve got temporal lobe epilepsy.. Temporal lobe epilepsy causes simple and complex partial seizures. Simple partial seizures simply cause unusual behaviours and patterns of cognition, including hallucinations and paranormal experiences; complex partial seizures can render the patient disabled and lose awareness temporarily. If one is unlucky though, it may spread and become a tonic-clonic seizure, a type of seizure that affects the entire brain, and is much more lethal.. ...
The temporal lobe would be the part in red. Only the left temporal lobe is shown.. The temporal lobe is separated into 2 parts: right and left. Its responsible for auditory processing, processing of semantic & lexical information in speech, and long-term memory. On the other hand, epilepsy aka seizure disorder is a common neurological disorder that causes recurrent & unprovoked seizures in patients. These seizures happen when clusters of neurons fire excessively/abnormally/synchronously. Combine these two, and youve got temporal lobe epilepsy.. Temporal lobe epilepsy causes simple and complex partial seizures. Simple partial seizures simply cause unusual behaviours and patterns of cognition, including hallucinations and paranormal experiences; complex partial seizures can render the patient disabled and lose awareness temporarily. If one is unlucky though, it may spread and become a tonic-clonic seizure, a type of seizure that affects the entire brain, and is much more lethal.. ...
PURPOSE OF REVIEW: This review summarizes recent evidence on the seizure, safety, cognitive and psychosocial outcomes of epilepsy surgery and their predictors. RECENT FINDINGS: Risks of serious surgical complications have dramatically decreased over years to drop below 1% for temporal lobe resections. Although chances of postoperative seizure freedom largely vary between recent series, some data suggest that long-term seizure control might be achieved in over 80% of patients with mesial temporal lobe epilepsy or neocortical epilepsy associated with type 2 focal cortical dysplasia, and in up to two-thirds of patients with extratemporal lobe epilepsy. In the same conditions, some recent series challenge the classic view that a normal MRI is associated with worse outcome, an important finding given the greater proportion of MRI-negative patients now considered for epilepsy surgery. SUMMARY: These provocative findings appear to partly reflect the advances in the optimal use or postprocessi
Early-onset absence epilepsy refers to patients with absence seizures beginning before age four and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a girl with intractable absence seizures with onset at age eight months. Her seizures were characterised by loss of responsiveness, with eyes drifting upwards and some myoclonic jerks of the upper and lower limbs. These symptoms were accompanied by bilaterally symmetric high-amplitude 2-2.5 Hz generalised spike-and-wave discharges on the electroencephalogram. Her seizures were refractory to conventional antiepileptic drugs; treatment with adrenocorticotropic hormone was transiently effective. Comprehensive metabolic screening, cytogenetic, and genetic analysis did not determine an underlying cause of her condition. Patients with intractable, very early-onset absence epilepsy with a myoclonic component have an unfavourable outcome and may be classified under a new epileptic ...
To evaluate the efficacy of steroid therapy in epileptic encephalopathies and refractory epilepsies other than West syndrome. Retrospective analysis of treatment and outcome data of patients treated with steroids for epileptic encephalopathies. Outco
AIM: The aim of this study was to define the prevalence of and risk factors for behavioural disorders in children with epilepsy from a rural district of Tanzania by conducting a community-based case-control study. METHOD: One hundred and twelve children aged 6 to 14 years (55 males, 57 females; median age 12 y) with active epilepsy (at least two unprovoked seizures in the last 5 y) were identified in a cross-sectional survey and included in this study. Children who were younger than 6 years were excluded in order to eliminate febrile seizures. Behaviour was assessed using the Rutter scale; children who scored 13 or more were considered to have disordered behaviour. A comparison group was made up of age- and sex-matched children without epilepsy (n = 113; 57 males, 56 females; median age 12 y). RESULTS: Behavioural disorders were diagnosed in 68 of 103 (66%) children with epilepsy and in 19 of 99 (19%) controls. Disordered behaviour was significantly more common in children with epilepsy than in the
The unprovoked epileptic seizure is considered to be one with no cause, which excludes seizures connected with acute infections, traumas, central nervous system haemorrhages or metabolic disorders (disorders of the homeostasis-acidosis, hypoglicaemia, electrolyte dysbalance). The decision whether to treat the first unprovoked epileptic seizure, the risk of repeated seizure or development into epilepsy in children and young adolescents may be found in the instructions based on evidence. Analysis of the evidence based data points out that a number of children will have another seizure in a certain time period or will develop epilepsy regardless of antiepileptic drug therapy; therefore, a decision to start therapy has to be made on an individual basis. The retrospective study was conducted at the Neuropaediatric Department of the University Hospital Sisters of Mercy, which showed that 29 out of 226 children staying on the ward developed a second unprovoked epileptic seizure. Broad diagnostic ...
TY - GEN. T1 - Dynamic seizure imaging in patients with extratemporal lobe epilepsy. AU - Lu, Yunfeng. AU - Yang, Lin. AU - Worrell, Gregory A.. AU - Brinkmann, Benjamin. AU - Nelson, Cindy. AU - He, Bin. PY - 2012/12/14. Y1 - 2012/12/14. N2 - Epilepsy is a common neurological disease that affects about 50 million people worldwide. Extratemporal lobe epilepsy, which represents an important type of epilepsy, may involve seizure activity in various lobes and the surgical treatment in these patients tends to have less favorable surgical outcome. Noninvasive seizure imaging in drug-resistant patients is of vital importance to image the seizure onset zones (SOZs) and understand the mechanisms for an improved treatment plan. In this study, we directly imaged the seizure sources in 8 extratemporal lobe partial epilepsy patients from noninvasive EEG. The surgically resected regions and SOZs identified from intracranial EEG (iEEG) recordings were used to evaluate the source imaging results. All of the ...
TY - JOUR. T1 - Epilepsy surgery of low grade epilepsy associated neuroepithelial tumors: A retrospective nationwide Italian study. AU - Giulioni, M.. AU - Marucci, G.. AU - Pelliccia, V.. AU - Gozzo, F.. AU - Barba, C.. AU - Didato, G.. AU - Villani, F.. AU - Di Gennaro, G.. AU - Quarato, P.P.. AU - Esposito, V.. AU - Consales, A.. AU - Martinoni, M.. AU - Vornetti, G.. AU - Zenesini, C.. AU - Efisio Marras, C.. AU - Specchio, N.. AU - De Palma, L.. AU - Rocchi, R.. AU - Giordano, F.. AU - Tringali, G.. AU - Nozza, P.. AU - Colicchio, G.. AU - Rubboli, G.. AU - Lo Russo, G.. AU - Guerrini, R.. AU - Tinuper, P.. AU - Cardinale, F.. AU - Cossu, M.. AU - Epilepsy, the Commission for Epilepsy Surgery of the Italian League Against. N1 - Export Date: 23 February 2018 Extracted concepts Epilepsy PY - 2017. Y1 - 2017. U2 - 10.1111/epi.13866. DO - 10.1111/epi.13866. M3 - Article. VL - 58. SP - 1832. EP - 1841. JO - Epilepsia. JF - Epilepsia. SN - 0013-9580. IS - 11. ER - ...
Epilepsy Southwestern Ontario would like to thank all thank all guests, sponsors, donors and volunteers who participated in our Game Show Gala!. We are sincerely overwhelmed with the continued success of the gala, all of which would not be possible without our sponsor and donors.. We are happy to announce that this years Gala surpassed our goal, raising over $30,000!! Proceeds from the event will help us to further our mission by providing education and support services.. Our Game Show Gala was hosted at Brookside Banquet Centre on April 7, 2018.. Epilepsy Southwestern Ontario has been presenting a H.O.P.E. award (Helping Out People with Epilepsy) since 2005. Each year, it is awarded to an individual, group of individuals or organization who has demonstrated compassion and caring for people living with epilepsy. This is Epilepsy Southwestern Ontarios highest honour and we are pleased that the Ontario Brain Institute & EpLink (the Epilepsy Research Program of OBI) have been chosen to receive ...
TY - JOUR. T1 - Modeling of intracerebral interictal epileptic discharges. T2 - Evidence for network interactions. AU - Meesters, Stephan. AU - Ossenblok, Pauly. AU - Colon, Albert. AU - Wagner, Louis. AU - Schijns, Olaf. AU - Boon, Paul. AU - Florack, Luc. AU - Fuster, Andrea. PY - 2018/6/1. Y1 - 2018/6/1. KW - Stereo-electroencephalography. KW - Analysis framework. KW - Interictal epileptic discharges. KW - Spatiotemporal network interaction. KW - Epilepsy surgery. KW - TEMPORAL-LOBE EPILEPSY. KW - INDEPENDENT COMPONENT ANALYSIS. KW - EPILEPTOGENIC NETWORKS. KW - SOURCE LOCALIZATION. KW - BLIND SEPARATION. KW - CLUSTER-ANALYSIS. KW - BRAIN NETWORKS. KW - EEG. KW - SIGNALS. KW - SEEG. U2 - 10.1016/j.clinph.2018.03.021. DO - 10.1016/j.clinph.2018.03.021. M3 - Article. VL - 129. SP - 1276. EP - 1290. JO - Clinical Neurophysiology. JF - Clinical Neurophysiology. SN - 1388-2457. IS - 6. ER - ...
Learn how Focal Cortical Dysplasia is diagnosed and the seizure types that may be seen with it. GARD Answers GARD Answers Listen. CAUTION patients with focal cortical dysplasia, who have earlier age of seizure onset, may have a change in their seizure types over time, with the emergence of epileptic spasms or generalized seizure types, such as atypical absences, atonic and tonic seizures. Epub 2020 Jan 20. COVID-19 is an emerging, rapidly evolving situation. Malformations of cortical development and epilepsies: neuropathological findings with emphasis on focal cortical dysplasia. Please enable it to take advantage of the complete set of features! As FCD type II cannot be diagnosed with certainty in the clinic, in vivo identification by use of MRI is important. Focal cortical dysplasia (FCD) is a congenital abnormality of brain development where the neurons in an area of the brain failed to migrate in the proper formation in utero. Epileptic Disord. It is characterized by epileptic seizures that ...
We have developed a number or resources to help gain more knowledge about epilepsy and ways to improve seizure control and quality of life. Many of these resources are for a broad audience while others are targeted toward a more specific audience.. E-quip, An Epilepsy Resource for Youth: Specifically designed for youth, this resource covers topics concerning youth and has a number of videos with young people discussing their experiences.. rEaction: This resource is also aimed at youth with a focus on increasing epilepsy awareness for friends and peers of people with epilepsy.. Strong Foundations: This resource is designed to help parents with a child attending mainstream school to identify if their child is experiencing epilepsy-related learning challenges. It aims to give parents ideas about how to support their child to achieve their potential.. There are two free short online courses for school aged children to learn about epilepsy. Epilepsy Awareness. ...
Conjoint A/Prof Annie Bye has an extensive portfolio of research into paediatric epilepsy and neurology, with over 70 original research articles together with 70 abstracts published in international and national peer reviewed journals. Research topics include neonatal seizures, neuropsychological and language profiles in paediatric epilepsy, MRI correlates of childhood epilepsy syndromes, quality of life in paediatric epilepsy, and education of epilepsy to patients and medical staff. This research has been supported by NHMRC, Ramichotti, Brain Foundation and Sydney Childrens Hospital Foundation funding bodies. She was awarded her MD for publications in epilepsy in 1996. Current Research Projects:. 1) The diagnostic yield of a genomic approach to infantile epileptic encephalopathy. 2) Paediatric Epilepsy Network. This is a major project to raise minimal standards of care in management of paediatric epilepsy across NSW. This work commenced in 2010. It has been funded by NSW Health (Statewide ...
ABSTRACTPatients with refractory epilepsy face an elevated risk of sudden death, with rates as high as 1% per year. This phenomenon, known as sudden unexpected death in epilepsy (SUDEP), is believed to be a seizure-related occurrence, but the exact underlying mechanisms are uncertain. Both pulmonary and cardiac pathophysiologies have been proposed. The cardiac mechanism of greatest interest is the precipitation of arrhythmias by seizure discharges via the autonomic nervous system. SUDEP prevention has centered on effective seizure control, and epilepsy surgery has reduced SUDEP incidence in a number of studies. Additional prophylaxis methods are needed, however, for the large number of patients with treatment-refractory epilepsy. Future research should aim to clarify whether the association between seizures and autonomic dysfunction and cardiac arrhythmias extends to a demonstrable cardiac mechanism for SUDEP.
OBJECTIVES: The prognostic value of acute postoperative seizures (APS) after epilepsy surgery is much debated. This study evaluated APS, defined as seizures in the first week post-surgery, as a predictor of long-term seizure outcome, and investigated the utility of other potential outcome predictors.. MATERIALS AND METHODS: Medical records of 48 patients with temporal and extra-temporal epilepsy surgery were studied. Forty patients had lesional surgery. All had at least 2 year postoperative follow-up.. RESULTS: At 2 year follow-up, 25 patients (53%) were seizure free. Univariate analysis showed that APS (P = 0.048), using ≥ six AEDs prior to surgery (P = 0.03), pathological postoperative EEG (P = 0.043) and female gender (P = 0.012) were associated with seizure recurrence.. CONCLUSIONS: Univariate analysis indicate that APS, a high number of AEDs used prior to surgery, and pathological postoperative EEG are possible predictors of seizure recurrence after epilepsy surgery. Only gender retained ...
FRIDAY, April 17, 2020 (HealthDay News) -- The main focus of epilepsy treatment is seizure control, but the aftereffects of seizures are also a major concern for many patients, experts say.. More than 70% of people with epilepsy say they have complications after a seizure -- including confusion, fear, exhaustion, headache, emotional reactivity, memory problems and behavioral changes -- that can last for hours or days, according to the International League Against Epilepsy.. In most cases, there are no treatments for these complications and why they occur is poorly understood. Currently, preventing seizures that trigger these complications is the only option.. Complications such as fear and confusion after a seizure can sometimes cause a patient to become aggressive if a bystander or first responder doesnt understand how to interact with a person whos just had a seizure, according to the league.. Fear and confusion are so common after a seizure that many epilepsy centers have had ...
Epilepsy is a chronic disorder that often requires long-term antiepileptic drug treatment; unfortunately, these drugs can have long-term side effects. Until recently, many physicians were reluctant to discontinue antiepileptic drugs because the risk for seizure recurrence was thought to be dangerously high. The study by Berg and Shinnar suggests that patients may have a better chance of remaining seizure-free than previously thought. By using meta-analysis, the authors evaluated a comprehensive group of primary studies that focused on seizure relapse after discontinuation of antiepileptic drugs. The review was carefully designed with no important methodologic problems. The risk for seizure relapse after antiepileptic drug withdrawal at 1 year was 25%, which represents the lowest risk for recurrence in patients with the most favorable clinical features. Berg and Shinnar assessed 3 clinical features that modified the recurrence risk. The risk was increased for adult- and adolescent-onset compared ...
Purpose: To study long-term postoperative course and identify predictors for postoperative seizure control in patients with medically intractable temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS), diagnosed by magnetic resonance imaging (MRI), and ascertained histopathologically. To compare patients becoming seizure-free (i.e., cured from epilepsy) and patients experiencing prolonged seizure-free periods interposed with recurring seizures.. Methods: One hundred thirty-five patients (74 women) underwent complete evaluation for epilepsy surgery. The predictive value of duration of epilepsy, age at onset, age at surgery, gender, febrile convulsion history, ictal dystonic posturing, unilateral interictal electroencephalography (EEG) discharges (IED), preoperative secondarily generalized tonic-clonic seizures (SGTCS), and preoperative seizure frequency for short- and long-term postoperative seizure control were evaluated with two classification systems: Classification 1 ...
One of Epilepsy Irelands key objectives is to undertake, encourage and fund research into all aspects of epilepsy. Epilepsy mortality has been identified as a key area where high calibre research is urgently needed worldwide and even within Ireland , there are many researchers with the interest and expertise to conduct this much needed research. Epilepsy Ireland has partnered with UK charity SUDEP Action and with UCC and Sheffield University to set up the Epilepsy Deaths Register for Ireland. The Register is based on the UK Epilepsy Deaths register launched in 2013 and shares much of the same infrastructure and personnel. The Epilepsy Deaths Register for Ireland was launched in 2015 and will provide:. ...
WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- Some children born to mothers with rheumatoid arthritis may have higher-than-average odds of developing epilepsy, a new study suggests.. Children born to mothers with rheumatoid arthritis were one-third more likely to develop epilepsy by age 4 than other children. The risk of epilepsy later in childhood was one-quarter higher for those born to moms with rheumatoid arthritis, the study found.. But, experts stressed that the findings dont prove that a mothers rheumatoid arthritis causes epilepsy. So far, only an association has been found.. And even if children of women with rheumatoid arthritis have a higher epilepsy risk than other kids do, the odds are still low.. In the study of nearly 2 million children, the vast majority of those born to moms with rheumatoid arthritis did not develop epilepsy, said lead researcher Ane Lilleore Rom, of Copenhagen University Hospital in Denmark.. Still, she said, the findings raise the possibility that when a ...
The Report on Epilepsy in Latin America and the Caribbean (2013) prepared by the Pan American Health Organization (PAHO/WHO) with the support of the International League against Epilepsy and the International Bureau for Epilepsy is now available. Spanish , English. ...
Through story books and movies, the world has often wondered what it might be like to read minds, but rarely has epilepsy played a role in this vision until now. Scientists are making breakthroughs every day in the studies of how the human brain works, but Neurologist Josef Parvizi of the Department of Neurology and Neurological Sciences at Stanford, along with his team of researchers, have worked with Epilepsy patients for their latest breakthrough.. The struggle that those with epilepsy work with is immediately felt by those that know someone touched by the disorder. Epilepsy is considered a disorder rather than a disease due to the fact it is not directly contagious in any way. Those in extreme cases can experience one or two grand mal seizures a month regardless of whether they are at home, work or even on the streets. The seizures are brought on by sudden changes in how the brain works. Over half of the cases of epilepsy are from unknown causes. The causes that are known include, stroke, ...
Post-traumatic epilepsy (PTE) is a form of epilepsy that results from brain damage caused by physical trauma to the brain (traumatic brain injury, abbreviated TBI). A person with PTE suffers repeated post-traumatic seizures (PTS, seizures that result from TBI) more than a week after the initial injury. PTE is estimated to constitute 5% of all cases of epilepsy and over 20% of cases of symptomatic epilepsy (in which seizures are caused by an identifiable organic brain condition). It is not known how to predict who will develop epilepsy after TBI and who will not. However, the likelihood that a person will develop PTE is influenced by the severity and type of injury; for example penetrating injuries and those that involve bleeding within the brain confer a higher risk. The onset of PTE can occur within a short time of the physical trauma that causes it, or months or years after. People with head trauma may remain at a higher risk for seizures than the general population even decades after the ...
Definition of focal epilepsy in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is focal epilepsy? Meaning of focal epilepsy as a legal term. What does focal epilepsy mean in law?
Nationally renowned pediatric epilepsy expert joins team Beaumont Childrens neuroscience team is the first in Michigan to establish a Pediatric Stereo-electroencephalography Epilepsy Surgery Program. Stereo-electroencephalography, also known as SEEG, is a minimally invasive diagnostic EEG within the skull that pinpoints the source of seizures. It replaces a craniotomy with smaller incisions - 2mm holes in the skull. In the traditional approach - the subdural EEG, a neurosurgeon removes a large part of the skull for EEG electrode implantation, explained Pramote Laoprasert, M.D., director of Beaumont Childrens Comprehensive Epilepsy Center. SEEG can identify the source of seizures deep within the brain without removing a part of the skull. It reduces surgery and anesthesia time. Patients experience much less pain with less medication and a faster recovery time, typically within 24-48 hours. SEEG performed with ROSA, a robotic assistance system, is more precise and a less invasive option of ...