TY - JOUR. T1 - Human epididymis protein 4 (HE4) plays a key role in ovarian cancer cell adhesion and motility. AU - Lu, Renquan. AU - Sun, Xinghui. AU - Xiao, Ran. AU - Zhou, Lei. AU - Gao, Xiang. AU - Guo, Lin. PY - 2012/3/9. Y1 - 2012/3/9. N2 - Human epididymis protein 4 (HE4) is a novel and specific biomarker for epithelial ovarian cancer (EOC). We previously demonstrated that serum HE4 levels were significantly elevated in the majority of EOC patients but not in subjects with benign disease or healthy controls. However, the precise mechanism of HE4 protein function is unknown. In this study, we generated HE4-overexpressing SKOV3 cells and found that stably transduced cells promoted cell adhesion and migration. Knockdown of HE4 expression was achieved by stable transfection of SKOV3 cells with a construct encoding a short hairpin DNA directed against the HE4 gene. Correspondingly, the proliferation and spreading ability of HE4-expressed cells were inhibited by HE4 suppression. ...
Background: Early diagnosis of ovarian cancer is essential for long term disease control and mortality reduction.This has been achieved using tumor markers like cancer antigen 125 (CA-125) which is elevated in malignant as wellas non-malignant conditions. This dilemma led to efforts towards development of newer markers like serum humanepididymis secretory protein E4 (HE4). Present study aimed to evaluate role of HE4 in diagnosing ovarian cancersand comparing it with CA-125. Methods: Serum samples from 67 patients with ovarian cancer, 42 with benignovarian masses and 26 healthy controls were collected preoperatively and tested for serum HE4 levels and CA-125levels. Diagnostic performance of both tumor markers (HE4/CA-125) to diagnose malignancy in ovarian masses wascalculated and compared to each other. Results: Mean CA-125 and HE4 levels were significantly higher in patientswith ovarian cancer than in those with benign disease (p|0.001) or healthy controls (p| 0.001). Serum HE4 levelssignificantly
Ovarian cancer is a common malignancy of the female reproductive system. Tumor markers serve as tools in the diagnosis of the disease. The aim of the present study was to determine the diagnostic value of sera levels of carbohydrate antigen-125 (CA-125), human epididymis protein 4 (HE4) as well as the area under the curve of the receiver operating characteristic (ROC) and the risk of ovarian malignancy algorithm (ROMA) index in ovarian cancer. The sera were measured using an electrochemiluminescence immunoassay on 158 individuals (64 patients with ovarian cancer, 64 with ovarian benign tumor and 30 healthy individuals) between September 2013 and May 2015. The results showed that levels of HE4 and CA‑125 in the sera of the ovarian benign tumor group as well as their ROMA index were significantly higher (P,0.05) than those of the ovarian benign tumor and control groups, regardless of pre‑ or postmenopausal status. However, the level of CA‑125 was significantly higher (P,0.05) in the ovarian ...
Background: The aim of this work was to analyze the diagnostic and prognostic value of serum human epididymis protein 4 (HE4) and Risk for Ovarian Malignancy Algorithm (ROMA) in epithelial ovarian cancer (EOC).. Methods: Preoperative serum samples of 419 women (140 healthy controls, 131 ovarian benign cysts, 34 endometriosis, and 114 EOC) were tested for CA125 and HE4 using fully automated methods (Abbott ARCHITECT) and validated cutoff values.. Results: For the discrimination of benign masses from EOC, in premenopausal women, the sensitivity and specificity were 92.3% and 59.4% for CA125, 84.6% and 94.2% for HE4, and 84.6% and 81.2% for ROMA, whereas in postmenopausal women, the sensitivity and specificity were 94.3% and 82.3% for CA125, 78.2% and 99.0% for HE4, and 93.1% and 84.4% for ROMA. In patients with EOC, elevated CA125, HE4, and ROMA levels were associated with advanced Federation of Gynaecologists and Obstetricians (FIGO) stage, suboptimally debulking, ascites, positive cytology, ...
Introduction: Ovarian cancer is one of the most common malignancies in women and the fifth cause of cancer-related deaths in women worldwide. Contrary to the challenges in developing new clinical markers using the conventional methods, recent advances in genomics and proteomics have led to identification of candidate and promising biomarkers for the diagnosis of ovarian cancer. Human epididymis protein 4 (HE4) is such a marker that has recently been reported to correlate with recurrence or progression of epithelial ovarian cancer. The purpose of this study was to measure the expression level of HE4 gene in women with ovarian cancer. Methodology: We evaluated and compared paraffin-embedded tissue samples of 20 ovarian cancer patients with 10 samples from healthy individuals. RNA was initially extracted from the samples and cDNA was synthetized. Gene expression level was then measured using real-time polymerase chain reaction (PCR). Results: Our results demonstrated that HE4 gene expression
Ovarian cancer has a poor prognosis. Most patients are diagnosed with ovarian cancer when the disease has reached an advanced stage and cure rates are generally under 30%. Hence, early diagnosis of ovarian cancer is the best means to control the disease in the long term and abate mortality. So far, cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) are the gold-standard tumor markers for ovarian cancer; however, these two markers can be elevated in a number of conditions unrelated to ovarian cancer, resulting in decreased specifically and positive predictive value. Therefore, it is urgent to identify novel biomarkers with high reliability and sensitivity for ovarian cancer. In this study for the first time, we identified a member of the centromere protein (CENP) family, CENPK, which was specifically upregulated in ovarian cancer tissues and cell lines and the overexpression of which was associated with poor prognoses in patients with ovarian cancer. In addition, the presence of CENPK
Fred Hutchinson Cancer Center researchers discovered that concentrations of the serum biomarkers CA125, human epididymis protein 4 (HE4), and mesothelin began to rise 3 years before clinical diagnosis of ovarian cancer, according to a new study published online December 30 in the Journal of the National Cancer Institute. However, the biomarkers became substantially elevated only…
Abstract Objective To evaluate the value of individual and combined measurement of human epididymis protein 4 (HE4) and cancer antigen 125 (CA-125) in the diagnosis of ovarian cancer. Methods A clinical case-control study was performed in which the levels of serum HE4 and CA-125 of subjects with malignant, borderline, benign ovarian tumors and healthy women were measured before surgery. An immunohistochemistry method was used to measure the expression of HE4 in different tissues. Statistical analysis was performed to determine the relationship between the level of HE4 and the pathologic type as well as the stage of the ovarian tumors. Results The level of HE4 in the serum was significantly elevated in the malignant ovarian cancer group compared with other groups. Women with benign ovarian tumors and non-neoplastic lesions, and healthy women were designated as references. When the level of HE4 in the serum was 58.66 pmol/L, the sensitivity and specificity of HE4 in diagnosing malignant ovarian tumors
Tissue Sentence Context Table 1. Analysis of context sentence of epididymis tissue in 1 abstracts. PMID Senteces 32347972 We found that there were significant increases in levels of human epididymis protein 4 (HE4) (73.
An Unusual Association of Lung and Ovarian Malignancy in a Young Nonsmoker Female: 10.4018/ijudh.2012100104: Lung cancer in a 25-year-old nonsmoker female is extremely rare. Ovarian malignancy in this age group is also infrequent and if occurs, is usually of germ
article{9a867211-15c1-48ad-af36-1d7fbbbfc375, abstract = {,p,BACKGROUND/AIM: To assess preoperative blood levels of a biomarker panel in relation to the new classification system of epithelial ovarian cancer (EOC) type I and II.,/p,,p,PATIENTS AND METHODS: Preoperative plasma levels of B7-family protein homolog 4 (B7-H4), intact and cleaved soluble urokinase plasminogen activator receptor (suPAR), human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) were analyzed in 350 patients with adnexal lesions.,/p,,p,RESULTS: The levels of suPAR(II-III), HE4, CA125 were all higher in EOC II than in EOC I, borderline and benign ovarian tumors. B7-H4 was increased in EOC II compared with benign ovarian tumors. The combination of suPAR(II-III), HE4, CA125 and age in premenopausal women discriminates EOC and borderline tumors from benign tumors to higher accuracy compared to the Risk of Ovarian Malignancy Algorithm (p=0.007).,/p,,p,CONCLUSION: The biomarker panel suPAR(II-III), HE4, CA125 and age in ...
Recent development of methods for genome‐wide identification of transcription factor binding sites by chromatin immunoprecipitation (ChIP) has led to novel insights into transcriptional regulation and greater understanding of the function of individual transcription factors
Bu çalışmada; kanserli çocuk hastalarda antikanser tedavinin infeksiyon hastalıklarında prokalsitonin ve C-reaktif proteinin tanısal değerleri üzerindeki etkisi araştırılmıştır. Çalışmamızda, antikanser tedavi alan ve ateş nedeniyle izlenen 63 kanserli çocuk hastanın 117 ateş atağı geriye dönük olarak değerlendirildi. Kontrol grubunda ise immün yetmezliği olmayan ateş ve infeksiyon nedeniyle yatarak tedavi görmüş 116 çocuk hastada görülen 117 ateş atağı değerlendirildi. Hastaların ateş başlangıcındaki laboratuvar bulguları, prokalsitonin ve C-reaktif protein değerleri, ateş odakları, kateter varlığı, kültür sonuçları, kullanılan antibiyotikler ve intravenöz antibiyotik tedavi süreleri incelendi. Antikanser tedavi alan ve ateş nedeniyle takip edilen hastalarda hemoglobin düzeyi, beyaz küre, trombosit ve mutlak nötrofil sayısı ortalama değerleri kontrol grubuna göre düşüktü (p ,0,001). Ateşli gün sayısı ölçeğinde ...
Pelvic masses are most commonly found in women, pelvic masses can also occur in men. Cases besides bladder distension and pregnancy need to be ruled out before workup. Consider every case as a malignancy. As age increases, so does the liklihood that malignancy could be a cause. ...
This paper presents a novel multiple serial code concatenation (SCC) strategy to combat the error-floor problem in iterated sparse graph-based error correc
Inquiry About Mouse WFDC5 ELISA Kit If you hope to order it or contact us directly, please contact us via [email protected] We will get back to you in 12hrs,Thanks! ...
In this article, we describe the generation and characterization of a novel CYP3A4 humanized mouse line that carries a replacement of the seven chromosomally closely linked murine Cyp3a genes with a large human genomic region carrying CYP3A4 and CYP3A7. A similar approach to replace large sequences of mouse genomic DNA with a syntenic region of human DNA was recently described for the α globin regulatory domain (Wallace et al., 2007). The use of a modified strategy allowed us to generate knockout control mice, Cyp3a(−/−)/3a13(+/+), carrying a deletion of the major part of the mouse Cyp3a cluster. Furthermore, because we used a different selection marker, our approach can be applied to any eukaryotic cell type and can therefore be used widely for the exchange of genomic regions between species.. The targeted insertion strategy applied in the present work distinguishes our huCYP3A4/3A7 model from other existing CYP3A4 humanized mouse lines. Compared with the random transgenic mouse line ...
E: epididymis (CA: caput, CO: corpus; CU: cauda). T: testis Other human epididymis _ specific gene products (Table 3) HUMAN EPIDIDYMAL cDNA FAMILIES HE1-HE6 Using a strategy of differential secreening of human epididymal cDNA libraries, a set of six major secretory proteins of human epididymal epithelial cells, named HE1-HE6, were identified (Kirchhoff et al, 1990). With the exception of HE5, the others are novel (human) gene products, not previously reported in animal studies. A brief description of HE1, HE2, HE3, HE4, HE5, and HE6 molecular characterization is presented in the following paragraphs. HE1: HE1 is a major secretory glycoprotein detected as a ~ 20 KDa protein, present within the epithelium and lumen of the corpus epididymis, and accumulated in the lumen of cauda epididymis and vas deferens. The mRNA encoding HE1 was found to be the most abundant gene product obtained using the strategy of differential screening. HE1 is well conserved among mammals (in chimpanzee, named EPI-1 (Perry ...
ID MOUSE14_PE1374 STANDARD; PRT; 793 AA. AC MOUSE14_PE1374; Q9JLN6; Q5D070; Q8K5D2; Q8K5D3; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE RecName: Full=Disintegrin and metalloproteinase domain-containing protein DE 28; Short=ADAM 28; EC=3.4.24 -;AltName: Full=Thymic epithelial cell-ADAM; DE Short=TECADAM;Flags: Precursor; (MOUSE14.PE1374). GN Name=Adam28; OS MUS MUSCULUS. OC Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; OC Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; OC Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; OC Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; OC Murinae; Mus. OX NCBI_TaxID=10090; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE14.PE1374. CC Mus musculus chromosome 14 NCBIM37 sequence 1..125194864 annotated by CC Ensembl CC -!- ANNOTATIONS ORIGIN:ADA28_MOUSE CC ...
The latest market report published by Credence Research, Inc. "Global Multiple Myeloma Treatment Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025," the Multiple Myeloma Treatment market was valued at USD 8,398.3 Mn in 2016, and is expected to reach USD 21,221.8 Mn by 2025, expanding at a CAGR of 11.0% from 2017 to 2025.. Browse the full report Multiple Myeloma Treatment Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025 at http://www.credenceresearch.com/report/multiple-myeloma-treatment-market. Market Insights. Multiple myeloma treatment options have developed significantly over the last decade. Novel multiple myeloma treatments have provided efficient survival rates among myeloma patients. It has been also observed that the upcoming drug pipeline of multiple myeloma is promising, biological drugs and stem cell based therapies are expected to drive the market in the near future. The key players operating in this industry ...
Ovarian cancer is a silent killer; however, improvements in identification of women at high risk for ovarian cancer, as well as improved imaging techniques, have increased the likelihood of early dete... more
The purpose of this study is to determine whether the Risk of Ovarian Cancer Algorithm (ROMA) is effective in the determination of a womans risk of can
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COVO MORALES, E.; DIAZ CABALLERO, A. e SIMANCAS PALLARES, M.. Gene expression esp (enterococcus surface protein) of enterococcus faecalis in an in vitro model of extracted teeth. Av Odontoestomatol [online]. 2016, vol.32, n.4, pp.195-204. ISSN 2340-3152.. Objective: To determine the presence and expression of Enterococcus faecalis Esp gene in several strains from an in vitro model on extracted teeth. Methods: An in vitro system was designed to evaluate the biofilm formation through fluorescence microscopy and gene expression that could be associated to biofilm formation. The system consisted of a previously extracted human tooth that was cut and prepared to provide by means of its root canal, an adequate surface for biofilm formation on behalf of Enterococcus faecalis. The system disposed an anaerobe chamber that allowed the growth of bacteria in broth culture and avoided contamination with other microorganisms. This chamber consisted of a sterile micro centrifuge tube, which was cut and united ...
R&D Systems has an exclusive range of biotinylated recombinant proteins tested for bioactivity to ensure specificity. Asses protein interactions in a range of assay formats, including immunoprecipitation, flow cytometry, immunoassays and surface plasmon resonance.
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
DEFB119 - DEFB119 (untagged)-Human defensin, beta 119 (DEFB119), transcript variant 3 available for purchase from OriGene - Your Gene Company.
Monoklonale und polyklonale WFDC1 Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für WFDC1 Antikörper. Hier bestellen.
Liu, Qiang and Hamil, Katherine G and Sivashanmugam, P and Grossman, Gail and Soundararajan, Rama and Rao, Jagannadha A and Richardson, Richard T and Zhang, Yong-Lian and ORand, Michael G and Petrusz, Peter and French, Frank S and Hall, Susan H (2001) Primate epididymis-specific proteins: Characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human. In: Endocrinology, 142 (10). pp. 4529-4539. ...
Magnetic bead-based MagJET nucleic acid purification kits provide high-purity DNA and RNA ready to use in routine and demanding downstream applications.
Djoba SJF ; Roberts T ; Babb C ; Black G ; Golakai HJ ; Stanley K ; Bapela NB ; Hoal EG ; Parida S ; van Helden PD ; Walzl G (2008) ...
HE 4 (proteina epididimala umana 4) este o proteina ce face parte din familia proteinelor acide din zer al caror miez contine 4 legaturi disulfidice (WFDC= whey acidic four-disulfide core) si care se presupune ca are proprietati inhibitorii asupra tripsinei. A fost identificata initial in epiteliul epididimului distal si i-a fost atribuit rolul de inhibitor de proteaza
Ovarian malignancy was found to be associated with ovarian, laryngeal, breast, endometrial, liver, and colon carcinoma, as well as myeloma; epithelial ovarian malignancy was found to be associated with ovarian, endometrial, and skin malignancies and with melanoma and myeloma; papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and endometrioid carcinoma was found to be associated with endometrial, ovarian, and prostate malignancies and with melanoma. For younger women (ages 40-45 years) whose mothers were affected with endometrial malignancies, the risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma. ...
Sperm maturation involves an intimate interaction between spermatozoa and the epididymal epithelium. Aspects of this relationship can be examined by co-incubating epididymal spermatozoa with epididymal epithelium in vitro. Plaques of epididymal epithelium from a variety of species (for example rodents, dogs, humans) can be maintained in culture medium supplemented with growth factors and androgens. When co-incubated with these epithelial cultures, immature epididymal spermatozoa undergo maturation changes that lead to the acquisition of progressive motility, zona binding and, in some instances, fertilizing capacity in vitro. The use of such co-culture techniques for the understanding of sperm maturation in vitro and in vivo is reviewed with reference to recent experiments.. ...
PubMed journal article: Pelvic actinomycosis mimicking ovarian malignancy: three cases. Download Prime PubMed App to iPhone, iPad, or Android
Perform reliable qPCR with Bio-Rads pre-validated Wfdc1 primer pair, for the Mouse genome. Designed for SYBR Green-based detection.
Complete information for DEFB121 gene (Protein Coding), Defensin Beta 121, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
ID AB698497; SV 1; linear; genomic RNA; STD; VRL; 3185 BP. XX AC AB698497; XX DT 17-AUG-2012 (Rel. 113, Created) DT 20-DEC-2012 (Rel. 115, Last updated, Version 2) XX DE Rosellinia necatrix mycovirus 2-W1032/S6 genes for hypothetical proteins DE and putative RNA-dependent RNA polymerase, partial and complete cds. XX KW . XX OS Rosellinia necatrix mycovirus 2-W1032/S6 OC Viruses; dsRNA viruses. XX RN [1] RP 1-3185 RA Yaegashi H., Kanematsu S.; RT ; RL Submitted (13-FEB-2012) to the INSDC. RL Contact:Hajime Yaegashi NARO, National Institute of Fruit Tree Science, RL Apple Research Station; Shimokuriyagawa, Nabeyasiki 92-24, Morioka, Iwate RL 0200123, Japan XX RN [2] RC DOI:10.1111/j.1574-6941.2012.01454.x RX PUBMED; 22808916. RA Yaegashi H., Nakamura H., Sawahata T., Sasaki A., Iwanami Y., Ito T., RA Kanematsu S.; RT "Appearance of mycovirus-like double-stranded RNAs in the white root rot RT fungus, Rosellinia necatrix, in an apple orchard"; RL FEMS Microbiol. Ecol. 83(1):49-62(2013). XX DR MD5; ...
TY - JOUR. T1 - Risk scores to guide referral decisions for people with suspected ovarian cancer in secondary care: a systematic review and cost-effectiveness analysis. AU - Westwood, Marie. AU - Ramaekers, Bram. AU - Lang, Shona. AU - Grimm, Sabine. AU - Deshpande, Sohan. AU - de Kock, Shelley. AU - Armstrong, Nigel. AU - Joore, Manuela. AU - Kleijnen, Jos. PY - 2018/8/1. Y1 - 2018/8/1. KW - MALIGNANCY ALGORITHM ROMA. KW - IOTA SIMPLE RULES. KW - MULTICENTER EXTERNAL VALIDATION. KW - ULTRASOUND-BASED RULES. KW - ADNEXAL MASSES. KW - PELVIC MASS. KW - DIAGNOSTIC-ACCURACY. KW - INDEX RMI. KW - PREOPERATIVE DIAGNOSIS. KW - POSTMENOPAUSAL WOMEN. KW - DIFFERENTIAL-DIAGNOSIS. KW - POSTOPERATIVE MORTALITY. KW - MENOPAUSAL STATUS. U2 - 10.3310/hta22440. DO - 10.3310/hta22440. M3 - Review article. VL - 22. SP - 1. EP - 266. JO - Health Technology Assessment. JF - Health Technology Assessment. SN - 1366-5278. IS - 44. ER - ...
Purpose Ovarian cancers is the deadliest of the gynecological malignancies. an intra-peritoneal Sera-2 xenograft model of human being L-779450 ovarian cancer. Results Here we statement the characterization of RA-9 like a small-molecule inhibitor of proteasome-associated DUBs. Treatment with RA-9 selectively induces onset of apoptosis in ovarian malignancy cell lines and main cultures derived from donors. Loss of cell viability following RA-9 exposure is definitely associated with an Unfolded Protein Response (UPR) as mechanism to compensate for unsustainable levels of proteotoxic stress. treatment with RA-9 retards tumor growth increases overall survival and was well tolerated from the sponsor. Conclusions Our preclinical studies support further evaluation of RA-9 as an ovarian malignancy therapeutic. experiments subconfluent ethnicities of Sera-2 ovarian malignancy cells were infected with lentiviral particles expressing the GFP reporter as we have previously defined (17 18 Ub-AMC protease ...
Complete information for DEFB129 gene (Protein Coding), Defensin Beta 129, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
talk , contribs)‎ . . (3,452 bytes) (+3,452)‎ . . (Created page with == Clinical Summary == The patient is a 46 year old female with a new pleural effusion, pelvic mass, and ascites. She presented to the ED with increasing abdominal distensio...) ...
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Kaempferol offers been reported to reduce the risk of ovarian malignancy, but the mechanism is not completely understood. cells, and better characterized kaempferol toward chemoprevention. angiogenesis caused by ovarian malignancy cells, and the pathways involve regulation on HIF1- and ERR- gene expressions (Luo et al., 2009). Anti-angiogenesis is probably the most feasible strategy for current chemoprevention of ovarian cancers, given the fact that these early-stage tiny tumors cannot be successfully diagnosed but their continued development desperately depends on the establishment of a new blood vessel network (Bertl et al., 2006; Carmeliet et al., 2000). Tumor-free adults, on the other hand, have virtually zero need for angiogenesis in normal situations (Fotsis et al., 1993; Glade-Bender et al., 2003). Thus our findings about kaempferols anti-angiogenesis effects (Luo et al., 2009) become more relevant in this context. Nevertheless, the previously investigated pathways for kaempferol are not ...
The MSLN gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor (MPF) and mesothelin. Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein that may function as a cell-adhesion protein. Mesothelin is cleaved by a furin-like protease to yield fragments of approximately 31 kDa and 40 kDa. In humans, mesothelin is overexpressed in epithelial mesotheliomas, ovarian cancers, and in some types of squamous cell carcinomas. The ERC (expressed in renal carcinoma) gene, which was identified in a rat model of renal cancer, has been proposed as a homolog of the human MSLN gene. It plays a role in cell adhesion and shape. Rat mesothelin was also shown to be dynamically expressed in the developing pancreas. In rat and mouse, mesothelin is also known as ERC/mesothelin, protein expressed in renal carcinoma, and pre-pro-megakaryocyte-potentiating factor.. ...
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