Vancomycin-Resistant Enterococcus Faecium Infections - Market Insights, Epidemiology and Market Forecast - 2025 is a market research report available at US $5750 for a Single User PDF License from RnR Market Research Reports Library.
Objectives: To characterize, phenotypically and genotypically, the first Enterococcus faecium clinical isolate harbouring a vanG operon.Methods: The antibiotic resistance profile of E. faecium 16-346 was determined and its whole genome sequenced using PacBio technology. Attempts to transfer vancomycin resistance by filter mating were performed and the inducibility of expression of the vanG operon was studied by reverse-transcription quantitative PCR (RT-qPCR) in the presence or absence of subinhibitory concentrations of vancomycin.Results: E. faecium 16-346 was resistant to rifampicin (MIC |4 mg/L), erythromycin (MIC |4 mg/L), tetracycline (MIC |16 mg/L) and vancomycin (MIC 8 mg/L), but susceptible to teicoplanin (MIC 0.5 mg/L). The strain harboured the vanG operon in its chromosome, integrated in a 45.5 kb putative mobile genetic element, similar to that of Enterococcus faecalis BM4518. We were unable to transfer vancomycin resistance from E. faecium 16-346 to E. faecium BM4107 and E. faecalis JH2-2.
Vancomycin-resistant Enterococcus faecium (VREfm) has emerged as an important global nosocomial pathogen, and this trend is associated with the spread of high-risk clones. Here, we determined the genetic and phenotypic features of 93 VREfm isolates that were obtained from patients in 13 hospitals in Vitória, Espírito Santo, Brazil, during 2012-2013. All the isolates were vancomycin-resistant and harbored the vanA gene. Only 6 (6.5%) of the VREfm isolates showed the ability to form biofilm. The 93 isolates analyzed belong to a single pulsed-field gel electrophoresis lineage and presented six subtypes. MLST genotyping showed that all VREfm belonged to ST412 (the high-risk clone, hospital-adapted). The present study describes the dissemination of ST412 clone in the local hospitals. The clonal spread of these ST412 isolates in the area we analyzed as well as other hospitals in southeastern Brazil supports the importance of identifying and controlling the presence of these microorganisms in health ...
This retrospective cohort study revealed that linezolid resistance in vancomycin-resistant Enterococcus faecium was dependent on prior linezolid exposure and duration of linezolid therapy. These strains of E. faecium were resistant to the entire class of oxazolidinones.. ...
Food supplements containing viable bacteria, so called probiotics, have been suggested to have beneficial health effects due to their influence on the normal microflora. However, there has been safety concern regarding probiotics containing Enterococcus faecium. Although part of the normal intestinal microflora in humans, enterococci can cause infections such as urinary tract infections, septicaemia, and endocarditis. Enterococci are also inclined to develop antibiotic resistance and their hardy nature promotes survival and dissemination in the hospital setting. Although the importance of E.faecium as a bloodstream isolate is increasing, little regarding its virulence is known. One virulence trait attributed to E. faecium is the enterococcal surface protein, Esp, encoded by the esp gene. Since enterococci have different roles from the human perspective, such as occurrence in food, as probiotic strains, members of the normal intestinal microflora, and as the cause of nosocomial infections, it is ...
The effects of Enterococcus faecium on growth, intestinal barrier function, and immune response in Escherichia coli O78-challenged broiler chickens were investigated. Three hundred eight 1-day-old Ross male chickens were randomly assigned into three treatment groups: negative control (C), E. coli O78-infected positive (EP), and E. coli O78-infected with 200 mg/kg E. faecium dietary supplementation (EF). E. faecium significantly increased the body weight on day 10 (P , 0.05) and day 15. Furthermore, these birds had a greater average daily gain compared with the other groups during days 1-10 (P , 0.05). The death rate of the EF chickens dramatically declined. E. faecium supplementation improved the jejunal villus height and the ratio of villus height to crypt depth (P , 0.05) 3 and 7 days post-infection. The mRNA expression of claudin-1 significantly increased by E. faecium (P , 0.05) 3 and 7 days post-infection, and Mucin2 was markedly enhanced (P , 0.05) 3 days post-infection. E. faecium ...
Background: Vancomycin-resistant Enterococcus faecium are difficult nosocomial pathogens to treat. Daptomycin (DAP) is a key front-line bactericidal antibiotic against VRE. Development of DAP resistance during therapy raises concerns about the role of DAP monotherapy in severe enterococcal infections. Limited previous data suggest that ceftaroline (CPT) enhances the in vitro activity of DAP against enterococci. We sought to evaluate the in vivo activity of DAP plus CPT against a DAP-R strain of E. faecium using an experimental infective endocarditis (IE) rat model. Methods: MICs and time-kill assays were performed using standard methods. IE was produced in carotid artery and jugular vein catheterized rats by intracardiac inoculation of 10X the ID90 of E. faecium HOU497. Therapy (3 days, via infusion pump) was begun 24 h after inoculation. Some animals were sacrificed at the time of therapy initiation to evaluate bacterial loads (T=0). Drug regimens included i) CPT, 30 min, 40 mg/kg q8h, ii) DAP, ...
The last 30 years Enterococcus faecium has become an important nosocomial pathogen in hospitals worldwide. The aim of this study was to obtain insight in the cell surface proteome of E. faecium when grown in laboratory and clinically relevant conditions. Enterococcus faecium E1162, a clinical blood stream isolate, was grown ... read more until mid-log phase in brain heart infusion medium (BHI) with, or without 0.02% bile salts, Tryptic Soy Broth with 1% glucose (TSBg) and urine, and its cell surface was "shaved" using immobilized trypsin. Peptides were identified using MS/MS. Mapping against the translated E1162 whole genome sequence identified 67 proteins that were differentially detected in different conditions. In urine, 14 proteins were significantly more and nine proteins less abundant relative to the other conditions. Growth in BHI-bile and TSBg, revealed four and six proteins, respectively, which were uniquely present in these conditions while two proteins were uniquely present in both ...
Surface filamentous structures designated pili, and implicated in virulence, have been found on the surfaces of several Gram-positive pathogens. This work describes the conditional expression of two phenotypically distinct pilus-like structures, designated PilA and PilB, on the surface of a hospital-adapted Enterococcus faecium bloodstream isolate. E. faecium is an emerging Gram-positive opportunistic pathogen that can cause severe disease, particularly in immunocompromised patients. Expression of PilA- and PilB-type pili was analysed during different phases of growth in broth culture. During growth, PilA and PilB pilin subunits were expressed around the cross-wall in early-exponential-phase cells. Polymerization and migration of short PilB-type pili towards the poles occurred in cells from the exponential phase and long polymerized pili were expressed at the poles of cells grown to stationary phase. In contrast, PilA-type pili were not expressed in broth culture, but only when cells were grown on solid
Wastewater treatment plants (WWTPs) are considered hotspots for the environmental dissemination of antimicrobial resistance (AMR) determinants. Vancomycin-Resistant Enterococcus (VRE) are candidates for gauging the degree of AMR bacteria in wastewater. Enterococcus faecalis and Enterococcus faecium are recognized indicators of fecal contamination in water. Comparative genomics of enterococci isolated from conventional activated sludge (CAS) and biological aerated filter (BAF) WWTPs was conducted. VRE isolates, including E. faecalis (n = 24), E. faecium (n = 11), E. casseliflavus (n = 2) and E. gallinarum (n = 2) were selected for sequencing based on WWTP source, species and AMR phenotype. The pangenomes of E. faecium and E. faecalis were both open. The genomic fraction related to the mobilome was positively correlated with genome size in E. faecium (p | 0.001) and E. faecalis (p | 0.001) and with the number of AMR genes in E. faecium (p = 0.005). Genes conferring vancomycin resistance, including vanA
Coloured scanning electron micrograph (SEM) of Enterococcus faecium (also known as Streptococcus faecium), Gram-positive, vancomycin resistant (VRE), coccus prokaryote that grows in groups or chains. E. faecium is commonly found in the guts of humans and other animals. It does not normally cause disease, but can be an opportunistic pathogen when the immune system is impaired. It is an important nosocomial (hospital-acquired) pathogen. E. faecium is known to have a resistance to several types of antibiotics including gentamicin, tetracycline, erythromycin, teicoplanin and penicillin. Magnification: x4,170 when shortest axis printed at 25 millimetres. - Stock Image C032/2608
As a popular medicine for probiotic therapy to treat with patients with diarrhea, the safety of Shin Biofermin S is paramount. Therefore, in the present study, the species of the SBS-1 strain isolated from a commercial medicine (Shin Biofermin S) was determined via genome sequencing. Species identification is important for evaluating safety and is favorable for formulating therapeutic strategies. The scientific names of E. faecium have been changed several times. Streptococcus faecalis and Streptococcus faecium were separate until 1984, when DNA-DNA and DNA-rRNA hybridization tests revealed that they belonged to Enterococcus instead (5). Bergeys Manual of Systematic Bacteriology Volume 3: The Firmicutes also demonstrated this result (6), such that Streptococcus faecalis was renamed Enterococcus faecalis. In the food and health industry, E. faecium and E. faecalis have been used to improve the intestinal environment by regulating its inflammatory status and the gut microflora (2). However, the ...
During a 36-month period between 1993 and 1995 in the Pediatric Oncology Unit of Memorial Sloan Kettering Cancer Center, 74 patients experienced episodes of infection or colonization caused by vancomycin-resistant enterococci (VRE). Characterization of the 74 bacterial isolates by microbiological an …
Antibacterials, Miscellaneous antibacterials, , indicated in the treatment of the following infections caused by susceptible strains of the designated microorganisms Linezolid is not indicated for the treatment of Gram-negative infections. It is critical that specific Gramnegative therapy be initiated immediately if a concomitant Gram-negative pathogen is documented or suspected Vancomycin-Resistant Enterococcus faecium infections, including cases with concurrent bacteremia . Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and -resistant strains), or Streptococcus pneumonia Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis, caused by Staphylococcus aureus Streptococcus pyogenes, or Streptococcus agalactiae. This drug has not been studied in the treatment of decubitus ulcers. Uncomplicated skin and skin structure infections caused by Staphylococcus aureus or Streptococcus pyogenes. Community-acquired
Virulence determinants in vancomycin-resistant **Enterococcus faecium vanB**: clonal distribution, prevalence and significance of **esp** and **hyl** in Australian patients with haematological disorders ...
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With the implementation of the Food and Drug Administrations Food Safety Modernization Act, the food industry must scientifically verify that current production processes provide sufficient protection against pathogens. This study was conducted to validate a simulated commercial baking process for hamburger buns to control Salmonella spp. contamination and to determine the appropriateness of using non-pathogenic surrogates (Enterococcus faecium ATCC 8459 or Saccharomyces cerevisiae) for in-plant process validation studies. Wheat flour was separately inoculated (~6 log CFU/g) with three Salmonella serovars (Typhimurium, Newport or Senftenberg) or E. faecium. Dough was formed, proofed, and baked to mimic commercial manufacturing conditions. Non-inoculated dough was used to evaluate S. cerevisiae (Bakers yeast) survival during baking. Buns were baked for 9, 11 and 13 min in a conventional oven set at 218°C, with internal bun temperature profiles recorded. Salmonella serovars and S. cerevisiae ...
BioAssay record AID 68231 submitted by ChEMBL: Compound was tested for the inhibition of cell wall biosynthesis and growth against Enterococcus faecium (ATCC51559) (Vancomycin-resistant).
BioAssay record AID 68567 submitted by ChEMBL: Tested in vitro for antibacterial activity against Enterococcus faecium using micro-broth dilution method.
Enterococcus Faecium (EF) is a probiotic and has been found when that dietary supplementation of EF can increase nutrient digestibility and decrease faecal
Enterococcus faecium ATCC ® 8459™ Designation: NCTC 2699 TypeStrain=False Application: Produces FAD flavin-adenine dinucleotide
TY - JOUR. T1 - Linezolid in bolus vs linezolid in continous infusion. The host response in patients with severe sepsis.. AU - Giarratano, Antonino. AU - Raineri, Santi Maurizio. PY - 2005. Y1 - 2005. N2 - INTRODUCTION AND AIMS: Severe sepsis by gram positive pathogens is commonly associated with high morbidity and mortalità in every ICU. During the sepsis the coagulation cascade, the complement system and the activation system are activated, in different moments, and this contributes to the development of multiple organ failure. This activation involves all system specially in late sepsis and contributes to the development of multiple organ failure associated with high mortality rate.Linezolid ia a one of a new class of antimicrobials (oxazolidinones) for the treatment of gram positive infection such as nosocomial pneumonia (including MRSA), community acquired pneumonia, complicate and uncomplicated skin infection and vancomycin resistant Enterococcus Faecium infection. In the study we propose ...
The high incidence of obesity in pet cats is a growing concern, and this problem is associated with serious diseases. Studies in mice models and human beings have shown that probiotics can reduce food intake, promote weight loss and improve metabolic profile (Aronsson and others 2010, Andersson and others 2010a, b, Takemura and others 2010, Everard and others 2011, Neyrinck and others 2012, Sanchez and others 2014, Zarrati and others 2014); however, similar studies are absent in cats. The study reported here did not identify any significant change within or between the control and probiotic E faecium SF68 supplementation group with respect to bodyweight, body condition score, lean body mass, fat mass per cent, blood glucose, cholesterol, triglyceride, insulin, fructosamine, leptin and total adiponectin concentrations after eight weeks of intervention and six weeks after discontinuation. Although daily food intake was significantly decreased after eight weeks of intervention and six weeks after ...
Exposure to chemicals that are commonly distributed in the environment and work-related surroundings may have deleterious effects to the nervous system. Acrylamide (ACR..
The high sensitivity of amplification by PCR requires the specimen to be processed in an environment in which contamination of the specimen by Vancomycin-Resistant Enterococcus DNA is unlikely.. Submit only 1 of the following specimens:. Supplies:. Culturette (BBL Culture Swab) (T092). C and S Vial (T058). Stool container, Small (Random), 4 oz Random (T288). Preferred:. Specimen Type: Perianal, perirectal, rectal. Container/Tube: Culture transport swab (Dacron or rayon swab with aluminum or plastic shaft with either Stuart or Amies liquid medium [T092]). Specimen Volume: Swab. Acceptable:. Specimen Type: Preserved Stool. Container/Tube: Commercially available transport system specific for recovery of enteric pathogens from fecal specimens (15 mL of non-nutritive transport medium containing phenol red as a pH indicator, either Cary-Blair, Para-Pak C and S [T058]). Specimen Volume: Representative portion of stool. Collection Instructions:. 1. Collect fresh stool and submit 1 gram or 5 mL in ...
Antibacterial activity of probiotic enterococci is often related to the production of bacteriocins. There is a variety of Enterococcus faecium strains which synthesise one or several enterocins including A, B, P, 96, L50AB and others. In this work we have analysed the probiotic strain E. faecium L3 whose genome contained the genes encoding enterocins А, В and a three-component reg ...
Food supplements containing viable bacteria, so called probiotics, have been suggested to have beneficial health effects due to their influence on the normal microflora. However, there has been safety concern regarding probiotics containing Enterococcus faecium. Although part of the normal intestinal microflora in humans, enterococci can cause infections such as urinary tract infections, septicaemia, and endocarditis. Enterococci are also inclined to develop antibiotic resistance and their hardy nature promotes survival and dissemination in the hospital setting. Although the importance of E.faecium as a bloodstream isolate is increasing, little regarding its virulence is known. One virulence trait attributed to E. faecium is the enterococcal surface protein, Esp, encoded by the esp gene. Since enterococci have different roles from the human perspective, such as occurrence in food, as probiotic strains, members of the normal intestinal microflora, and as the cause of nosocomial infections, it is ...
Facing Our Antibiotic Dilemma, Jordan Reinbold. Antibiotic resistance is on the rise, and so is the buzz surrounding it. Since they were first introduced, antibiotics have been misguided and misused. This has lead to multiple bacteria that are now resistant to our miracle drugs. This review paper intends to inform the public about three of these bacteria; methicillin-resistant staphylococcus aureus (MRSA), clostridium difficile, and vancomycin-resistant enterococcus faecium (VRE). Also reviewed is a specific case from a university teaching hospital regarding a 12 year resistance study and an interview was conducted with a current Doctorate of Nursing Practice student. These resources provide general education about these resistant bacteria in hopes to inspire increased awareness. Read more. A look at current MRSA rates in the Midwest: Are they increasing or decreasing? Michael Aanes. Methicillin-resistant Staphylococcus Aureus (MRSA) have been a significant problem in hospitals worldwide. ...
My research project aims at finding bioactive compounds from a marine sponge, family Halichondriidae. This involves extraction/isolation, purification and structure elucidation of the bioactive compound(s).. The extraction procedure employs liquid-liquid partitioning of the crude extract in order to obtain Hexane, Dichloromethane, Butan-2-ol and Methanol fractions. Further fractionation carried out by flash column chromatography follows bioassay (bioassay guided fractionation). The bioassay involves tests against Vancomycin-resistant Enterococcus faecium (VREF), Methicillin-resistant Staphylococcus aureus (MRSA), wild type Staphylococcus aureus (WTSA), Wild-type Candida albicans (WTCA) and Amphotericin B- resistant Candida albicans (ARCA). Brine Shrimp assay (general cytotoxicity) is also carried out for the crude and fractions. The bioactive extracts are further subjected to semi-preparative High Performance Liquid Chromatography (HPLC) for purifications followed by spectroscopic techniques ...
Avene makes great products for those suffering from dry sensitized skin as well…? Many of these side effects can be avoided in patients with angina by using beta blockers that work primarily on the heart itself, asthalin mdi dose and that have relatively little effect on the blood vessels, lungs, and central nervous system. Co? Empiric docilely cozaar cost therapy for vancomycin-resistant Enterococcus faecium is not recommended unless the patient is at high risk of infection! Por y Para: zwei Präpositionen auf Spanisch, asthalin ax syrup price Regeln, Gebrauch und Beispiele, Übungen 20102007 · Mejor respuesta: hola: Sirv? On July 27, 2006, Congress passed the Adam Walsh Act, which among other innovations, removed the statute of limitations for sex crimes against children and established a comprehensive program for the registry of convicted sex offenders. Based on urinary recovery, the mean extent of absorption of lisinopril is approximately 25%, with large intersubject variability (6-60%) ...
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3ZG4: The Structure of Enterococcus Faecium L,D---Transpeptidase Acylated by Ertapenem Provides Insight Into the Inactivation Mechanism.
Prodigest is a well-balanced mixture of vitamins, amino acids, electrolytes and enterococcus faecium. This product contains a unique composition that stimulates the pigeons natural resistance. The feathers soften considerably, the flesh becomes more pink and the pigeons will shed more down. The composition of the vitamins and amino acids stimulates a faster recovery and condition building. Thanks to the presence of the electrolytes, the pigeons will become rounder and the excellent intake of moisture ensures the muscle building.. The enterococcus faecium, the added probiotic, ensures the good flow of the intestinal flora and the organism is being stimulated. This is why we recommend to have the product at your disposal all the time as a support for the young pigeons against the feared adeno virus. The structure of Prodigest ensures that, when you add it to the food, the food will be better digested which helps the pigeons build a better resistance and get in shape faster ...
6. Antibiotic resistance issues: However, some strains of E. faecium may be pathogenic and harmful to humans, and can cause bacteraemia, endocarditis, urinary tract and other infections. Moreover, anti-microbial resistance (AMR) to many commonly used antibiotics has been reported, and E. faecium is the leading cause of multi-drug resistant enterococcal infections in humans. It is thought that about 70% of E. faecium strains in US hospitals are resistant to vancomycin and 90% are resistant to ampicillin. E. faecium resistance is acquired by gene transfer systems, such as conjugative and non-conjugative plasmids or transposons. Virulence of E. faecium strains is not well understood, but adhesins, haemolysin, hyaluronidase, aggression substance and gelatinase are putative virulence factors. These virulence genes may be transferred to human endogenous strains present in the gastrointestinal tract, which may contribute to increasing the virulence factors of this genus and endogenous strains. Concerns ...
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Piglets fed probiotic Enterococcus faecium showed reduced numbers of potentially pathogenic Escherichia coli strains in their intestines, according to a team of
Im not a microbiologist/virologist so pardon me for my ignorance...Im using Enterococcus faecium as a host for producing bacteriaphage. I understand there is a method for determining the efficiency for various strains to produce phage. From what I understand efficiency of plating is different than plaque forming units and is measuring the % of virions that causes plaque for a particular stain. Is there such a method out there? How can i get a hold of one? Thanks lamb wrote: , Cecil Hunter wrote: , , , Im interested in finding a good protocol for efficiency of plating. , , What do you mean? , , Loes , , , Im particulary interested in using the bacteria Enterococcus in my , , assay. , , , , Any help would be appreciated. -------------- next part -------------- An HTML attachment was scrubbed... URL: http://iubio.bio.indiana.edu/bionet/mm/microbio/attachments/19991103/79fbbda6/attachment.html ...
To create Enterocid Duo, we have carefully selected two strains of bacteria showing the best synergistic qualities - Enterococcus faecium and Bacillus amyloliquefaciens. Their composition strenghtens the digestive system of birds from the first days of their lives. We also added Zinc chelate, as it shows results better by 60% with regard to supporting the immune and digestive system if compared with standard forms of this mineral ...
Vancomycin-resistant Enterococcus (VRE) has been established as a significant health-care associated problem since its first isolation in Australia in 1994. In this study, we measured the point prevalence and identified risk factors associated with v
Enterococci are medically important bacteria that also happen to comprise part of the normal human intestinal flora. This chapter reviews an expanding literature on enterococcal physiology, emphasizing those topics that have been more thoroughly studied: central carbon metabolism, respiration, ion transport, pyrimidine and folate pathways, stress responses, and the metabolism of reactive oxygen species. The newly completed genome databases for Enterococcus faecalisand E. faecium speeds up progress in many areas under current investigation. In addition, these databases should catalyze new studies on metabolism. These resources are used here to help identify putative genes in known or suspected metabolic pathways and spur additional interest in the many fascinating and unusual aspects of physiology for these medically important organisms. A wide variety of carbohydrates can be fermented by enterococci. Essential components of the E. faecalisrespiratory chain-de-methylmenaquinone, cytochrome bd, fumarate
PROFESÖRLÜK İSTANBUL ÜNİVERSİTESİ, İSTANBUL KALP DAMAR CERRAHİSİ KLİNİĞİ KURUCU ŞEFİ BAKIRKÖY DR SADİ KONUK EĞİTİM VE ARAŞTIRMA HASTANESİ, KALP-DAMAR CERRAHİSİ KLİNİĞİ, İSTANBUL DOÇENTLİK
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Enterococcus faecium BM4165 and BM4178, isolated from immunocompromised patients, one treated with vancomycin, were inducibly resistant to high levels of the glycopeptide antibiotics vancomycin and teicoplanin but susceptible to the new lipopeptide daptomycin (LY146032). Strain BM4165 was also resistant to macrolidelincosamide-streptogramin B-type (MLS) antibiotics. The genes conferring resistance to glycopeptides and to MLS antibiotics in strain BM4165 were carried on plasmids pIP819 and pIP821, respectively; pIP819 also carried genes that encoded resistance to MLS antibiotics. The two plasmids, which were distinct although related, were self-transferable to other E. faecium strains. Plasmid pIP819 could also conjugate to E. faecalis, Streptococcus sanguis, S. pyogenes, S. lactis, and Listeria monocytogenes, in which it conferred inducible glycopeptide resistance, but not to S. aureus. Glycopeptide-inactivating activity was not detected, and the biochemical mechanism of resistance remains ...
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RESULTS: A total of 66 of the 405 rectal swab surveillance cultures obtained from 46 inpatients were positive for VRE, among which 27 inpatients were culture-positive for VRE on admission to medical ICU, and 19 inpatients were initially culture-negative but converted to culture-positive after admission. All isolates carried vanA gene consisting of 51 Enterococcusgallinarum, 13 Enterococcus faecium, and two Eenterococcus casseliflavus. Of the 51 E. gallinarum isolates, 40 were type ST 341, seven were ST 252, two were ST 78, and two were ST 64. The Enterococcus spp., MLST and PFGE subtypes were almost similar among these two groups of inpatients. Linezolid and tigecycline were most active against VRE in vitro ...
Dalfopristin is a semi-synthetic streptogramin antibiotic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A). The combination quinupristin/dalfopristin (marketed under the trade name Synercid) was brought to the market by Rhone-Poulenc Rorer Pharmaceuticals in 1999. Synercid (weight-to-weight ratio of 30% quinupristin to 70% dalfopristin) is used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. Through the addition of diethylaminoethylthiol to the 2-pyrroline group and oxidation of the sulfate of ostreogrycin A, a structurally more hydrophobic compound is formed. This hydrophobic compound contains a readily ionizable group that is available for salt formation. Dalfopristin is synthesized from pristinamycine IIa through achieving a stereoselective Michael-type addition of 2-diethylaminoethanethiol on the conjugated double bond of the dehydroproline ring . The first method found was using sodium periodate associated with ruthenium ...
Background: Vancomycin-resistant Enterococcus (VRE) are important hospital-acquired pathogens among hematopoietic cell transplant (HCT) recipients. We examined the incidence and outcomes of patients with VRE colonization and bacteremia (VREB) over a ten-year period at a center that routinely screens and uses barrier precautions for VRE. Methods: Adults receiving their first allogeneic HCT at our center between September 2007 and August 2016 were eligible for inclusion. Patients who were positive either by standardized pre-HCT stool/rectal screening or at any point two years prior to HCT were considered VRE colonized. Patients with acquired VRE were those with positive VRE cultures only post-HCT. Colonization and 100-day post-HCT VREB incidence rates were compared over time using linear regression. Cox proportional hazards models were constructed to assess the relationship between 100-day mortality and: a) pre-HCT colonization, and b) the number of days with sequential VREB cultures. ...
Enterococci can be used in the food industry as starter or probiotic cultures. However, enterococci are also implicated in severe multi-resistant nosocomial infections. In this study, the prevalence of enterococci in selected Brazilian foodstuffs (raw and pasteurized milk, meat products, cheeses and vegetables) was evaluated. Phenotypic and PCR protocols were used for species identification. Tests for production of gelatinase, haemolysin, bacteriocin and bile salt hydrolysis were done with all enterococci isolates, whereas molecular determination of virulence markers (genes esp, gel, ace, as, efaA, hyl and cylA) and antibiotic resistance was checked only for Enterococcus faecium and Enterococcus faecalis isolates. The antibiotic-resistant isolates were assayed for biofilm formation and adhesion to mammalian cells. From the 120 food samples analyzed, 52.5% were positive for enterococci, meat and cheese being the most contaminated. E. faecium was the predominant species, followed by E. faecalis, ...
Cost-Effectiveness of Perirectal Surveillance Cultures for Controlling Vancomycin-Resistant Enterococcus - Volume 23 Issue 8 - Carlene A. Muto, Eve T. Giannetta, Lisa J. Durbin, Barbara M. Simonton, Barry M. Farr
Since the discovery of penicillin, bacteria have counteracted the action of antibiotics leading to a worrisome situation about antibiotic efficiency. During our research on non-traditional 1,3-bridged β-lactams embedded into macrocycles as potential inhibitors of Penicillin Binding Proteins (PBPs), we unexpectedly synthesized bis-2-oxoazetidinyl macrocycles arising from a dimerization reaction under ring closing metathesis (RCM) conditions. These molecules were revealed to be good inhibitors of the d,d-peptidase from Actinomadura R39, which is commonly used as a model of PBPs. To pursue the research on this type of novel compounds, a complete family of cyclodimers 4 and 5 was synthesized and evaluated against R39, and high molecular weight d,d-peptidases: PBP2a of methicillin-resistant Staphylococcus aureus and PBP5 of resistant Enterococcus faecium. Some bis-2-oxoazetidinyl macrocycles exhibited very promising activities against PBP2a. In order to explain the biological results, docking ...