Background: Leclercia adecarboxylata is a motile, aerobic, gram-negative bacillus previously reported to cause clinically significant solitary bacterial infections in immunocompromised patients, as well as polymicrobial wound infections in immunocompetent patients. The human gastrointestinal (GI) tract is a known reservoir for this rarely pathogenic organism, and may be a source for bacterial translocation into the blood. Case and Methods: A 51-year-old Filipino female with a history of hypertension, type II diabetes mellitus, and end stage renal disease on hemodialysis, presented to multiple emergency departments with persistent fever, nausea, vomiting, and abdominal pain over the course of two weeks. Blood cultures collected during one of her visits grew Leclercia adecarboxylata. She was called back to the hospital and admitted for further work-up. Computed tomography revealed possible small bowel wall thickening. Given her presenting symptoms, the GI tract was considered the most likely ...
To correlate the patient characteristics, clinical manifestations, severity of illness (the modified Pitt bacteremia score), diagnosis of deep-site infection, co-morbid conditions (including diabetes mellitus, hepatic and renal dysfunction), length of stay in ICU/hospitalization, the presence of invasive procedures, source of pathogen (community acquired or nosocomial infection), antimicrobial regimen (i.e carbapenems versus non-carbapenems(flomoxef or quinolones), microbiological characteristics (E coli and Kleb. pneumoniae) and outcome endpoints (clinical outcome and mortality) with ESBL recurrence and ...
Protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (249 aa ...
Lipopolysaccharide export system protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA; Belongs to the LptC family (192 aa ...
TY - JOUR. T1 - Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice. AU - Clare, Simon. AU - John, Victoria. AU - Walker, Alan W. AU - Hill, Jennifer L. AU - Abreu-Goodger, Cei. AU - Hale, Christine. AU - Goulding, David. AU - Lawley, Trevor D. AU - Mastroeni, Pietro. AU - Frankel, Gadi. AU - Enright, Anton J. AU - Vigorito, Elena. AU - Dougan, Gordon. PY - 2013/3. Y1 - 2013/3. N2 - MicroRNAs (miRNAs) are small noncoding molecules that control gene expression posttranscriptionally, with microRNA-155 (miR-155) one of the first to be implicated in immune regulation. Here, we show that miR-155-deficient mice are less able to eradicate a mucosal Citrobacter rodentium infection than wild-type C57BL/6 mice. miR-155-deficient mice exhibited prolonged colonization associated with a higher C. rodentium burden in gastrointestinal tissue and spread into systemic tissues. Germinal center formation and humoral immune responses against C. rodentium were severely impaired ...
Source: Centre for Health Protection, Hong Kong PRC SAR, full page: (LINK).]. Case of NDM-1 Carbapenemase-producing Enterobacteriaceae under CHP investigation. The Public Health Laboratory Services Branch (PHLSB) of the Centre for Health Protection (CHP) of the Department of Health confirmed today (October 16) a case of New Delhi metallo-β-lactamase-1 (NDM-1) Carbapenemase-producing Enterobacteriaceae in a 25-year-old man.. The patient, with good past health, lived in Hong Kong. He travelled to Guangdong Province on September 21 and sustained a severe head injury in a traffic accident on September 27. He was admitted to a local hospital and subsequently transferred to Prince of Wales Hospital for further management on October 4. The patient passed away on October 7.. The patients rectal swab yielded NDM-1 Carbapenemase-producing Enterobacteriaceae as confirmed by the PHLSB.. His travel collaterals and home contacts are asymptomatic. The case has been referred to the coroner for further ...
The increasing trend of β-lactam resistance among Enterobacteriaceae is a worldwide threat. Enterobacteriaceae isolates causing intra-abdominal infections (IAI) from the Study for Monitoring Antimicrobial Resistance Trends (SMART) collected in 2008 and 2009 from the Asia-Pacific region were investigated. Detection of extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases, and carbapenemases was performed by multiplex PCR. A total of 699 Enterobacteriaceae isolates with positive genotypic results, included Escherichia coli (n = 443), Klebsiella pneumoniae (n = 187), Enterobacter cloacae (n = 45), Klebsiella oxytoca (n = 9), Citrobacter freundii (n = 5), Proteus mirabilis (n = 3), Enterobacter aerogenes (n = 2), Morganella morganii (n = 2), and one each of Enterobacter asburiae, Proteus vulgaris, and Providencia rettgeri were analyzed. Nearly 20% of these β-lactamase-producing Enterobacteriaceae isolates were from community-associated IAI. CTX-M (588 isolates, including 428 [72.8%] with ...
The intestinal epithelial cells (IECs) that line the gut form a robust line of defense against ingested pathogens. We investigated the impact of infection with the enteric pathogen Citrobacter rodentium on mouse IEC metabolism using global proteomic and targeted metabolomics and lipidomics. The major signatures of the infection were upregulation of the sugar transporter Sglt4, aerobic glycolysis, and production of phosphocreatine, which mobilizes cytosolic energy. In contrast, biogenesis of mitochondrial cardiolipins, essential for ATP production, was inhibited, which coincided with increased levels of mucosal O2 and a reduction in colon-associated anaerobic commensals. In addition, IECs responded to infection by activating Srebp2 and the cholesterol biosynthetic pathway. Unexpectedly, infected IECs also upregulated the cholesterol efflux proteins AbcA1, AbcG8, and ApoA1, resulting in higher levels of fecal cholesterol and a bloom of Proteobacteria. These results suggest that C. rodentium ...
BACKGROUND: Ceftaroline is a novel oxyimino-cephalosporin, strongly active against methicillin-resistant staphylococci and pneumococci. It is active against Enterobacteriaceae too, but is labile to common beta-lactamases, including AmpC and extended-spectrum types. To counteract these enzymes, ceftaroline is also being developed combined with NXL104, a beta-lactamase inhibitor.. METHODS: Chequerboard MIC titrations were performed to determine the NXL104 concentrations needed to protect ceftaroline against beta-lactamase-producing Enterobacteriaceae, most of them with ceftaroline MICs ,16 mg/L.. RESULTS: All of 60 extended-spectrum beta-lactamase (ESBL) producers were susceptible to ceftaroline + NXL104, 1 + 1 mg/L, as were 5/5 Klebsiella oxytoca with high-level K1 enzyme. Among 30 Enterobacteriaceae with high-level chromosomal AmpC, 18 were susceptible at 1 + 1 mg/L, 28 at 1 + 4 mg/L and all at 4 + 4 mg/L; among 10 with plasmid AmpC enzymes, nine were susceptible at 1 + 1 mg/L and all at 1 + 4 ...
Carbapenemase-producing Enterobacteriaceae (CPE) are rapidly spreading worldwide. Early detection of fecal CPE carriers is essential for effective infection control. Here, we evaluated the performance of a meropenem combined disk test (CDT) for rapidly differentiating CPE isolates directly from rectal swabs. The screening method was applied for 189 rectal swabs from hospitalized patients at high risk for CPE carriage. Swabs were suspended in 1 ml saline and cultured for confluent growth onto a MacConkey agar plate with a meropenem (MER) disk alone, a MER disk plus phenyl boronic acid (PBA), a MER disk plus EDTA, and a MER disk plus PBA and EDTA. An inhibition zone of ,= 25 mm around the MER disk alone indicated carriage of carbapenem-resistant organisms. Furthermore, ,= 5-mm differences in the inhibition zone between MER disks without and with the inhibitors (PBA, EDTA, or both) were considered positive results for detecting Klebsiella pneumoniae carbapenemase (KPC), metallo-beta-lactamase ...
Despite the unfavorable double-room configuration of our ICU, the 4.1% rate of ESBL acquisition was much lower than the 13% reported by Razazi et al. in a 24-bed ICU with eight single rooms but without any protocol of contact precautions for ESBL carriers [13]. It is close to that reported by Alves et al. in an ICU with only single rooms, in which contact precautions were also applied [17]. Unlike Barbier et al., who reported that half of the ESBL carriers acquired their ESBL during their ICU stay [16], and Gardam et al., who reported that ESBL acquisition accounted for two-thirds of ESBL carriage in the ICU [18], ESBL acquisition accounted for only 12.7% of all ESBL carriage in our study, confirming that ESBL carriage is mostly imported, whereas high-level cephalosporinase (HL-Case) is mostly acquired, in the ICU [19]. In multivariate analysis, the severity (SAPS II) at admission was the only factor identified to be associated with the acquired carriage of ESBL, while some authors have reported ...
The results indicated that spring waters could become a reservoir of antibiotic resistant bacteria and contribute to the spread of antimicrobial-resistant bacteria via drinking water or food chain. In addition, wastewater discharge of restaurants or hotels may be an important contribution source of …
Background. Plasmid-mediated quinolone resistance (PMQR) has received considerable attention recently. Data analysis in Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER) revealed 75% of the Enterobacteriaceae isolates to be ciprofloxacin-resistant in 2012. Few reports regarding the prevalence of PMQR are available from India. Hence, the present study was carried out to ascertain the prevalence of PMQR genes among clinical isolates of ciprofloxacin-resistant Enterobacteriaceae in JIPMER. Methods. The study included 642 ciprofloxacin-resistant clinical Enterobacteriaceae isolates. JIPMER hospitals annual consumption data for fluoroquinolones were retrieved from the Department of Pharmacy. The test isolates were screened for the presence of qnr A, B, D, S and aac(6′)-Ib-cr genes. PMQR-positive isolates alone were tested for the presence of class I (intI1) and class II (intI2) integrons. Randomly selected PCR amplicons were sequenced and analysed using MEGA software. A total of
In this study we analysed the spectrum of Enterobacteriaceae in tracheal aspirates of intubated PICU patients from 2005 to 2014. The spectrum of Enterobacteriaceae in lower respiratory tract material revealed Enterobacter spp., E.coli and Klebsiella spp. as the most common isolates (86%). Comparable data of matching study settings are scarce in the current literature. Wilson et al. [5] collected daily tracheal aspirates from intubated children. Consistent with our findings, the most common Gram-negative organisms isolated were Klebsiella spp. and E.coli, followed by Citrobacter freundii and Enterobacter cloacae. Lee et al. [34] described the microbiological spectrum and susceptibility pattern of clinical isolates from a PICU and found a rate of 20% ESBL-positive Klebsiella in 2005. Our study displayed a lower rate with only 6.5% of Klebsiella spp. isolates being ESBL-positive. However, more than half of E.coli isolates (55%), about a quarter of all Klebsiella spp. (28%) isolates and 4 out of 6 ...
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing worldwide, and are a major threat to healthcare systems. Recent European data support that many
An outbreak of multidrug-resistant Enterobacter cloacae infection lasted for 4 months in a neonatal intensive care unit (NICU). Forty-six isolates from the NICU and 20 epidemiologically unrelated strains were characterized by pulsed-field gel electrophoresis (PFGE) and repetitive extragenic palindromic unit b1-primed PCR (REPUb1-PCR) typing. The PFGE patterns after XbaI restriction of the bacterial DNA were analyzed by computer software (Gelcompar) using the UPGMA (unweighted pair group method with arithmetic averages) clustering method and the Dice coefficient. The 46 isolates from the NICU were classified by PFGE typing into five clusters: A (further classified into 7 subtypes, A1 to A7), B, C, D, and E. This outbreak was attributed to multiple genetically related strains of cluster A which had a similarity of 85.8% +/- 4.6%. The minor band differences among strains of cluster A were probably due to minor genetic mutations. The type A1 and A3 strains were isolated from the clinical specimens ...
Carbapenem resistant Enterobacteriaceae are a class of bacteria that are resistant to multiple antibiotics, including carbapenems, which are considered last-resort drugs when other antibiotics have failed.. CRE, which tend to spread in hospitals and long-term care facilities, cause an estimated 9,300 infections and 600 deaths in the U.S. each year, according to the U.S. Centers for Disease Control and Prevention (CDC).. And incidence is on the rise.. Tom Frieden, director of the CDC, has called these nightmare bacteria because they are resistant to some of the last-ditch treatments available to doctors fighting resistant infections.. The researchers looked at about 250 samples of CRE from hospitalized patients from three Boston-area hospitals and from one California hospital. Their goal was to obtain a snapshot of the genetic diversity of CRE, to define the frequency and characteristics of outbreaks, to find evidence of strains being transmitted within and between hospitals, and to learn how ...
Paper of the week: Orthopedic Implant-Associated Infection by Multidrug Resistant Enterobacteriaceae. Pfang BG, García-Cañete J, García-Lasheras J, Blanco A, Auñón Á, Parron-Cambero R, Macías-Valcayo A, Esteban J. J Clin Med. 2019 Feb 8;8(2). pii: E220. doi: 10.3390/jcm8020220. Summary and Editorial by Sreeram Penna This is a retrospective observational study from a single institution. Researchers reviewed…
Carbapenem -resistant Enterobacteriaceae (CRE) and the Imperative for Antimicrobial Stewardship. Christopher Trabue, M.D. September 13, 2013. Outline. Background and Epidemiology Clinical significance and public health implications Slideshow 2067038 by kylia
Macrophages play pleiotropic roles in maintaining the balance between immune tolerance and inflammatory responses in the gut. Here, we identified transcription factor RBP-J as a crucial regulator of colonic macrophage-mediated immune responses against the enteric pathogen Citrobacter rodentium . In the immune response phase, RBP-J promoted pathogen clearance by enhancing intestinal macrophage-elicited Th17 cell immune responses, which was achieved by maintenance of C/EBPβ-dependent IL-6 production by overcoming miRNA-17∼92-mediated suppressive effects. RBP-J deficiency-associated phenotypes could be genetically corrected by further deleting miRNA-17∼92 in macrophages. In the late phase, noneradicated pathogens in RBP-J KO mice recruited abundant IL-1β-expressing CD64 + Ly6C + colonic macrophages and thereby promoted persistence of ILC3-derived IL-22 to compensate for the impaired innate and adaptive immune responses, leading to ultimate clearance of pathogens. These results demonstrated ...
Achaogen is a late-stage biopharmaceutical company passionately committed to the discovery, development, and commercialization of innovative antibacterial treatments for MDR gram-negative infections. Achaogen is developing plazomicin, its lead product candidate, for the treatment of serious bacterial infections due to MDR Enterobacteriaceae, including carbapenem-resistant Enterobacteriaceae. The Food and Drug Administration has granted plazomicin Breakthrough Therapy designation for the treatment of bloodstream infections caused by certain Enterobacteriaceae in patients who have limited or no alternative treatment options. The Companys second product candidate is C-Scape, an orally-administered product candidate for the treatment of serious bacterial infections due to ESBL-producing Enterobacteriaceae. Achaogens plazomicin program has been funded, and its C-Scape program is funded, in part with federal funds from the Biomedical Advanced Research and Development Authority (BARDA). Achaogen has ...
ESBL/AmpC producing Enterobacteriaceae have been reported worldwide amongst isolates obtained from humans, food-producing animals, companion animals and environmental sources. However, data on prevalence of fecal carriage of ESBL/AmpC producing Enterobacteriaceae in healthy companion animals is limited. This pilot study describes the prevalence of ESBL/AmpC encoding genes in healthy cats and dogs, and cats and dogs with diarrhea. Twenty fecal samples of each group were cultured on MacConkey agar supplemented with 1 mg/L cefotaxime and in LB-enrichment broth supplemented with 1 mg/L cefotaxime, which was subsequently inoculated on MacConkey agar supplemented with 1 mg/L cefotaxime. ESBL/AmpC genes were identified using the Check-Points CT103 micro array kit and subsequently by sequencing analysis. Chromosomal ampC promoter mutations were detected by PCR and sequencing analysis. From the healthy and diarrheic dogs, respectively 45% and 55% were positive for E. coli with reduced susceptibility for
Background: Carbapenemase-producing Enterobacteriaceae(CPE) is a global health issue due to their hasty dissemination through the transfer of carbapenemase genes. Hence, rapid detection is necessary to take relevant control measures against CPE infections/colonization. We established a rapid and multiplex CPE detection system - Single Tag Hybridization Printed Array Strip (STH-PAS) by targeting the four different major carbapenemases. STH-PAS is a DNA-DNA hybridization technique where the oligonucleotide tag in the primer of PCR product hybridizes to its probe imprinted on a chromatographic strip without denaturation. Further, the efficacy of STH-PAS in detecting CPE directly in clinical samples is evaluated. Methods: STH-PAS was tailored to detect various alleles of the four carbapenemase genes - NDM, KPC, IMP, and OXA-48 like in a single reaction. Then, the efficiency of hybridization in STH-PAS for detection of carbapenemases was compared with conventional PCR. The efficiency of carbapenemase ...
Multidrug-resistant bacterial infections in critical ill cancer patients has become a trending problem in the last years because of the challenge provided in treatment, of the limited tools in our...
Background: Transmaternal exposure to tobacco, microbes, nutrients, and other environmental factors shapes the fetal immune system through epigenetic processes. The gastric microbe Helicobacter pylori represents an ancestral constituent of the human microbiota that causes gastric disorders on the one hand and is inversely associated with allergies and chronic inflammatory conditions on the other. Objective: Here we investigate the consequences of transmaternal exposure to H pylori in utero and/or during lactation for susceptibility to viral and bacterial infection, predisposition to allergic airway inflammation, and development of immune cell populations in the lungs and lymphoid organs. Methods: We use experimental models of house dust mite- or ovalbumin-induced airway inflammation and influenza A virus or Citrobacter rodentium infection along with metagenomics analyses, multicolor flow cytometry, and bisulfite pyrosequencing, to study the effects of H pylori on allergy severity and immunologic ...
The prevalence of carbapenem-resistant Gram-negative bacilli is on the rise worldwide, posing a major public health threat. Previously, this was mostly a problem in Pseudomonas and Acinetobacter, but during the last decade, carbapenem resistance has escalated in medically important species such as K …
Public Health Ontario (PHO) is a Crown corporation dedicated to protecting and promoting the health of all Ontarians and reducing inequities in health. PHO links public health practitioners, front-line health workers and researchers to the best scientific intelligence and knowledge from around the world.
Extended-spectrum β-lactamase-producing Enterobacteriaceae in urine or feces is a substantial risk factor for subsequent EPE-bloodstream infection.
Enteropathogenic E. coli (EPEC), Enterohaemorhagic E. coli (EHEC) and Citrobacter rodentium are constituent members of the attaching and effacing (A/E) pathogens. The A/E group of bacteria are considered to be extracellular pathogens which form characteristic lesions by intimately adhering to host enterocytes and directing the effacement intestinal brush border. EPEC and EHEC are diarrhoeal pathogens, which are a global health burden in developing and industrialised countries respectively. Citrobacter rodentium is a murine pathogen which is an excellent animal model for EPEC and EHEC infection. EPEC, EHEC and C. rodentium conserve a genomic region termed the locus of enterocyte effacement (LEE) which encodes a type 3 secretion system (T3SS), a core set of type 3 secreted effector proteins and the outer membrane adhesin intimin, which are essential for A/E lesion formation. A/E pathogens utilise their T3SSs to translocate dozens of effector proteins directly from the bacteria into host cells. ...
Pulmonary drug delivery offers several advantages in the treatment of respiratory diseases over other routes of administration. Inhalation therapy enables the direct application of a drug within the lungs. The local pulmonary deposition and delivery of the administered drug facilitates a targeted treatment of respiratory diseases, such as pulmonary arterial hypertension (PAH), without the need for high dose exposures by other routes of administration. The intravenous application of short acting vasodilators has been the therapy of choice for patients with PAH over the past decade. The relative severity of side effects led to the development of newprostacyclin analogues and alternative routes of administration. One such analogue, iloprost (Ventavis® ), is a worldwide approved therapeutic agent for treatment of PAH. Inhalation of this compound is an attractive concept minimizing the side effects by its pulmonary selectivity. Unfortunately, the short half-life of iloprost requires frequent ...
|i>Enterobacteriaceae|/i> are spread worldwide and the diseases they cause may be fatal especially in immunocompromised patients. Moreover, the high prevalence of ESBL producing Salmonella and...
Enterobacterial infections Definition Enterobacterial infections are disorders of the digestive tract and other organ systems produced by a group of rod-shaped bacteria called Enterobacteriaceae.
Learn more about Extended Spectrum Beta-Lactamase Infection at TriStar Centennial Parthenon Pavilion DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
The Enterobacteriaceae vial is a membrane vial, monitoring a change in color due to a pH shift as Enterobacteriaceae organisms ferment.
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 26 April - 2 May 2015, and includes updates on Multidrug-resistant Enterobacteriaceae, influenza, Salmonella Enteritidis, Borna virus, measles, rubella and Ebola virus. ...
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 26 April - 2 May 2015, and includes updates on Multidrug-resistant Enterobacteriaceae, influenza, Salmonella Enteritidis, Borna virus, measles, rubella and Ebola virus. ...
TY - JOUR. T1 - Identification of TonB homologs in the family Enterobacteriaceae and evidence for conservation of TonB-dependent energy transduction complexes. AU - Larsen, Ray A.. AU - Myers, Paul S.. AU - Skare, Jonathan T.. AU - Seachord, Carrie L.. AU - Darveau, Richard P.. AU - Postle, Kathleen. PY - 1996/3. Y1 - 1996/3. N2 - The transport of Fe(III)-siderophore complexes and vitamin B12 across the outer membrane of Escherichia coli requires the TonB-dependent energy transduction system. A set of murine monoclonal antibodies (MAbs) was generated against an E. coli TrpC-TonB fusion protein to facilitate structure and function studies. In the present study, the epitopes recognized by these MAbs were mapped, and their distribution in gram-negative organisms was examined. Cross-species reactivity patterns obtained against TonB homologs of known sequence were used to refine epitope mapping, with some epitopes ultimately confirmed by inhibition experiments using synthetic polypeptides. Epitopes ...
A trial of the Enterotube system for the identification of Enterobacteriaceae and a comparison with the methods at present in use in the Tygerberg Hospital Microbiology Laboratory, were carried out.
Lineage: cellular organisms; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; unclassified Enterobacteriaceae; unclassified Enterobacteriaceae (miscellaneous ...
Callefi, Luciana Azevedo, Medeiros, Eduardo A. and Furtado, Guilherme Henrique Campos Predictors of 14-day mortality in patients with bloodstream infections caused by Enterobacteriaceae strains: a mathematical PK/PD analysis. Braz J Infect Dis, Apr 2012, vol.16, no.2, p.211-213. ISSN 1413- ...
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List of words make out of Enterobacterial. Anagrams of word Enterobacterial. Words made after scrabbling Enterobacterial. Word Creation helps in Anagrams and Puzzles.
Edwardsiella tarda is a member of the Enterobacteriaceae family. The bacterium is a facultatively anaerobic, small, motile, gram negative, straight rod with flagella. Infection causes Edwardsiella septicemia (also known as ES, edwardsiellosis, emphysematous putrefactive disease of catfish, fish gangrene, and red disease) in channel fish, eels, and flounder. Edwardsiella tarda is also found in largemouth bass and freshwater species such as rainbow trout. It is a zoonosis and can infect a variety of animals including fish, amphibians, reptiles and mammals. Edwardsiella tarda has also been the cause of periodic infections for various animals within zoos. E. tarda has a worldwide distribution and can be found in pond water, mud, and the intestine of fish and other marine animals. It is spread by carrier animal feces. The creation of the species was suggested by Ewing and colleagues in 1965 in order to cover 37 different strains that mainly were found in fecal materials. Japanese and other scientists ...
Murphy, CT, Hall, LJ, Hurley, G, Quinlan, A, MacSharry, J, Shanahan, F, Nally, K and Melgar, S (2012) The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium. Infection and Immunity, 80 (8). pp. 2712-2723. ISSN 0019-9567 Full text not available from this repository. (Request a copy ...
Carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae (CPE) are Gram-negative bacteria that are resistant to the carbapenem class of antibiotics, considered the drugs of last resort for such infections. They are resistant because they produce an enzyme called a carbapenemase that disables the drug molecule. The resistance can vary from moderate to severe. Enterobacteriaceae are common commensals and infectious agents. Experts fear CRE as the new "superbug". The bacteria can kill up to half of patients who get bloodstream infections. Tom Frieden, former head of the Centers for Disease Control and Prevention has referred to CRE as "nightmare bacteria". Types of CRE are sometimes known as KPC (Klebsiella pneumoniae carbapenemase) and NDM (New Delhi Metallo-beta-lactamase). KPC and NDM are enzymes that break down carbapenems and make them ineffective. Both of these enzymes, as well as the enzyme VIM (Verona Integron-Mediated Metallo-β-lactamase) have also been ...
The genus Citrobacter was originally distinguished from other members of the Enterobacteriaceae by its ability to use citrate as a carbon source. Citrobacter infection is commonly reported in neonates and immunocompromised patients. Citrobacter koseri, formerly known as Citrobacter diversus, is best known as the cause of sepsis and meningitis leading to central nervous system (CNS) abscesses in neonates and young infants. The majority of cases are sporadic, with no clear source of infection. A significant number of the infants with abscesses die, and many sustain CNS damage. It adults, however, Citrobacter infection with central nervous system involvement is rare, and is usually associated with an underlying disorder. Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) was isolated in 1983 in Maryland where it caused neonatal meningitis. ...
N.C. Communicable Disease Branch page about new carbapenem-resistant Enterobacteriaceae (CRE), untreatable or difficult-to-treat Enterobacteriaceae that have developed high levels of resistance to antibiotics, including last-resort antibiotics called carbapenems. Includes NC DHHS and CDC communications about this emerging public health concern as well as links to infection prevention information tailored for patients and healthcare providers.
Trends in carbapenem-resistant Enterobacteriaceae (CRE) collected from hospitals nationwide in Singapore over 3 years are presented. Hospital isolates with imipenem or meropenem minimum inhibitory concentrations (MICs) of ,1 mg/L were sent to the National Public Health Laboratory for further investigation. A total of 400 CRE were submitted, 227 (56.8%) of which carried a carbapenemase gene. blaNDM was the most common (130/400; 32.5%), followed by blaOXA-48-like (blaOXA-48, -181, -232) (55/400; 13.8%). Interestingly, four isolates bearing dual carbapenemase genes were also detected. KPC- and OXA-48-like-producing Klebsiella pneumoniae were fingerprinted by DiversiLab® rep-PCR. Locally, KPC producers do not appear to have clonal dissemination. In contrast, OXA-48-like producers were found to have a greater degree of clustering than KPC producers. © 2013 International Society for Chemotherapy of Infection and Cancer ...
Carbapenem-Resistant Enterobacteriaceae (CRE) are untreatable or difficult to treat bacteria that are resistant to carbapenem antibiotics and nearly all available antibiotics. They can cause serious illness and death; bloodstream infections are fatal in 40% -50% of cases. CRE was designated by the CDC in 2013 as one of the three most urgent drug resistant threats in the United States. An estimated 9,000 CRE infections cause 600 deaths yearly in the U.S.. Risk factors for CRE colonization or infection include open wounds, presence of indwelling devices (such as endotracheal tubes, feeding tubes, and catheters), multiple medical problems, and high antimicrobial use. CRE are easily spread between infected or colonized patients by health care workers and equipment, unless rigorous infection prevention precautions are taken. Cases and outbreaks of CRE have been increasingly recognized in recent years in Northern California, including Alameda County. In June 2017, the Alameda County Public Health ...
Provider Role in Transmission of Carbapenem-Resistant Enterobacteriaceae - Volume 38 Issue 11 - Marika E. Grabowski, Hyojung Kang, Kristen M. Wells, Costi D. Sifri, Amy J. Mathers, Jennifer M. Lobo
Carbapenem-resistant Enterobacteriaceae (CRE) are a serious threat to public health. Infections with CRE are difficult, and in some cases impossible, to treat and have been associated with mortality rates up to 50%(1). Due to the movement of patients throughout the healthcare system, if CRE are a problem in one facility, then typically they are a problem in other facilities in the region as well. To help protect patients and prevent transmission, CDC has updated 2012 CRE toolkit; this document will continue to be updated as new information becomes available.. ...
In this study of the diversity of AmpC beta-lactamase in clinical isolates of Enterobacter spp., a strain was found carrying the plasmid-mediated AmpC beta-lactamase ACT-1 gene on its chromosome. The strain was identified as Enterobacter hormaechei using phylogenetic analysis of 16S rRNA and hsp60 genes. In addition, the species was confirmed by DNA DNA hybridization. The genetic environment of the bla(ACT-1) gene was characterized, including the ampR and ampG genes, using a two-step PCR. The amino acid sequences of AmpR at serine 35, arginine 86, glycine 102, aspartic acid 135 and tyrosine 264 were conserved. Measurement of the transcription level of the bla(ACT-1), gene using real-time quantitative PCR showed that it increased 1.98-fold following cefoxitin induction. These results suggest that the plasmid-mediated bla(ACT-1) gene originated from the chromosome of E. hormaechei ...
Edwardsiella tarda, a member of the family Enterobacteriaceae, has recently become recognized as pathogenic, especially in patients with an underlying illness. In the present report, a patient had sickle cell hemoglobinopathy and E tarda bacteremia.
About 21% of international travelers-and 37% of travelers with diarrhea who had taken antibiotics-may be colonized with drug-resistant bacteria, according to a study yesterday in Clinical Infectious Diseases.. Researchers collected stool samples from 430 Finns before and after they traveled outside of Scandinavia. They tested for extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) and carbapenemase-producing Enterobacteriaceae (CPE), two drug-resistant "superbugs.". They found that 90 of the travelers, or 21%, became colonized by ESBL-PE after traveling, but none by CPE. For travelers to South Asia, the prevalence rose to 46%.. The rate of ESBL-PE was 11% in those without travelers diarrhea (TD) or antimicrobial use, 21% for those with TD and no antimicrobial use, and 37% in those with both TD and antimicrobial use.. Those numbers climbed to 14%, 37%, and 69%, respectively, in travelers to Southeast Asia, and to 23%, 47%, and 80% in travelers to South Asia.. "More than 300 ...
Over a 6-month period, eight strains of Citrobacter diversus (Citrobacter koseri) resistant to extended-spectrum cephalosporins and monobactams were isolated from seven colonized and/or infected patients from the same intensive care unit. All strains harbored a single large conjugative plasmid which mediated an extended-spectrum beta-lactamase of the SHV-4 type (ceftazidimase phenotype; enzyme pI, 7.8; plasmid DNA hybridization with a blaSHV-specific probe). All strains were characterized by antibiotic resistance pattern analysis, beta-lactamase content analysis, plasmid profiling, ribotyping with EcoRI, and arbitrarily primed (AP)-PCR with primers O8 and O12. Among the eight C. diversus strains, strains Cd5 to Cd12, six isolates (isolates Cd6 to Cd11) were identical by all markers; one strain (strain Cd5) differed by two markers (antibiotype and AP-PCR pattern with primer O8), and the remaining strain (strain Cd12) differed by two other markers (ribotype and AP-PCR pattern with primer O12). Our ...
What are carbapenem-resistant Enterobacteriaceae (CRE)? Enterobacteriaceae are a group of bacteria normally found in the human gut. Common types include E. coli and Klebsiella species. Carbapenems are a class of antibiotics that were developed to treat bacteria that are resistant to other drugs. Due to the overuse of these antibiotics, some types of Enterobacteriaceae have developed resistance to carbapenems; these bacteria are called carbapenem-resistant Enterobacteriaceae (CRE).. Who gets CRE? Healthy people usually do not get CRE infections. In healthcare settings, CRE infections may occur among patients who are receiving treatment for other conditions. Patients whose care requires devices like ventilators (breathing machines), urinary (bladder) catheters, or intravenous (vein) catheters, and patients who are taking long courses of certain antibiotics are most at risk for CRE infections.. How are CRE spread? CRE can be transmitted via direct person-to-person contact with an infected person or ...
Enterobacteriaceae is a family of Gram negative bacilli which can cause a wide range of community acquired and nosocomial infections including infections of the urinary and gastrointestinal tracts, pneumonia, peritonitis, meningitis, sepsis and medical device associated infections (Surinder Kumar, 2012; Wang et al., 2015; Harbaik et al., 2014). These organisms easily acquire and transfer drug resistance genes through plasmids and transposons (Okoche et al., 2015). Carbapenem are beta lactam antibiotics and are the last resort for the treatment of severe infections caused by multidrug resistant Gram negative bacilli (Gupta et al., 2006; Roy et al., 2011). Reports indicate that carbapenemases producing Enterobacteriaceae (CRE) isolates seem to be increasing in number in the last few years (Nagaraj et al., 2012).
Cronobacter sakazakii is a Gram-negative pathogen found in milk-based formulae that causes infant meningitis. Bacteriophages have been proposed to control bacterial pathogens; however, comprehensive knowledge about a phage is required to ensure its safety before clinical application. We have characterized C. sakazakii phage vB{sub C}saM{sub G}AP32 (GAP32), which possesses the second largest sequenced phage genome (358,663 bp). A total of 571 genes including 545 protein coding sequences and 26 tRNAs were identified, thus more genes than in the smallest bacterium, Mycoplasma genitalium G37. BLASTP and HHpred searches, together with proteomic analyses reveal that only 23.9% of the putative proteins have defined functions. Some of the unique features of this phage include: a chromosome condensation protein, two copies of the large subunit terminase, a predicted signal-arrest-release lysin; and an RpoD-like protein, which is possibly involved in the switch from immediate early to delayed early ...
TY - JOUR. T1 - In Vitro Effectiveness of Meropenem and Cefmetazole Combination Treatment Against KPC-2-Producing Enterobacteriaceae. AU - Hagiya, Hideharu. AU - Aoki, Kotaro. AU - Akeda, Yukihiro. AU - Yamamoto, Norihisa. AU - Shanmugakani, Rathina Kumar. AU - Ishii, Yoshikazu. AU - Tomono, Kazunori. PY - 2019/7/1. Y1 - 2019/7/1. N2 - Purpose: Optimal treatment regimens are yet to be established for carbapenemase-producing Enterobacteriaceae (CPE). We assessed the in vitro efficacy of meropenem (MEM) and cefmetazole (CMZ) combination treatment against blaKPC-2-positive Enterobacteriaceae, in comparison with that of double-carbapenem therapy using ertapenem (ERT). Materials and Methods: We performed checkerboard assay for 10 blaKPC-2-positive clinical isolates and Klebsiella pneumoniae BAA-1705 (possessing blaKPC-2), with synergistic effect being defined by a fractional inhibitory concentration index of ≤0.5. Subsequently, we conducted time-kill assays using K. pneumoniae BAA-1705 with an ...
We describe a case of infection with Cronobacter sakazakii sequence type 494 causing bacteremia and meningitis in a hospitalized late premature infant in Brazil. We conducted microbiological analyses on samples of powdered infant formula from the same batch as formula ingested by the infant but could not identify the source of contamination.
CDC reports on a case of cronobacter sakazakii infection caused by consumption of extrinsically contaminated expressed human milk.
The emergence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (E-ESBL) is a major public health problem. It leads more frequent prescription of penems with the risk of emergence and spread of strains producing carbapenemases, which may be resistant to all known antibiotics. A policy of savings of penems is desirable. Among the alternatives to penems, amikacin is in the foreground. It remains active on the majority of E-ESBL strains. Some risk factors for E-ESBL emergence are known: recent antibiotic therapy (particularly quinolones and cephalosporins third generation), previous hospitalization or residence in a high endemic country.. In pediatrics, E-ESBLs are primarily responsible for urinary tract infection. In France, E-ESBLs represent about 10% of the strains responsible for urinary tract infections. The Pathology Group Pediatric Infectious (GPIP) of the French Society of Pediatrics (SFP) and the Society of Infectious Pathology French Language (SPILF) have proposed different ...
In this report we have added to our understanding of the role of ILK in intestinal pathophysiology, specifically in the setting of bacterial infection. Similar to the findings reported for DSS-induced colitis we show that there is a reduced inflammatory response, associated with a reduction in CCL2 expression, an important immune cell chemoattractant. Furthermore, our findings indicate that the pattern but not the magnitude of epithelial C. rodentium binding is altered in the ILK-ko mice, with preserved apical binding but reduced lateral epithelial cell binding/migration, in between adjacent crypts. Although the reduced expression of fibronectin may account for this finding, we cannot exclude alterations in other extracellular matrix components, or alterations in the levels of other cell surface integrins as being involved in this response. An additional role for ILK is indicated by the reduced crypt hyperplasia observed associated with decreased cyclin D1 on immunohistochemistry, in ILK-ko ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Enterobacter aerogenes ATCC ® 15038D-5™ Designation: Genomic DNA from Enterobacter aerogenes strain IFO 12010 TypeStrain=False Application:
Enterobacter aerogenes ATCC ® 15038D-5™ Designation: Genomic DNA from Enterobacter aerogenes strain IFO 12010 TypeStrain=False Application:
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It was a week into my elderly patients hospital admission when he began to have fever and profuse diarrhea, some 10-12 bowel movement a day. The diagnosis was not hard to make: a stool test showed he had C difficile. Another patient, a thin women in her late 40s who had become paraplegic after a […]. ...
(PRWEB) May 15, 2015 -- GeneWEAVE, Inc.,a clinical diagnostics company addressing multi-drug-resistant organisms (MDRO), announced that initial data presented
Manual curation resolved these bifurcations and reduced the number of Citrobacter contigs from ∼1,400 to 10 (the largest curated contig is 2.55 Mb) (Fig. 3B). The final contigs are generally syntenous with the Citrobacter 30_2 strain draft genome (Broad Institute, Cambridge, MA) and the complete Citrobacter koseri ATCC BAA-895 genome (Washington University, St. Louis, MO). Consequently, the fragments were oriented and ordered by reference to the C. koseri genome to generate a final genome representation for the dominant strain, UC1CIT-i (Table S6 in Dataset S2). Of the ten genome gaps, eight are the rRNA-encoding regions that could not be resolved, one is within a prophage, and one is in the intergenic region between genes on contig ends that are adjacent in both isolate genomes.. Citrobacter species are facultative anaerobes from the family Enterobacteriaceae and are commonly found as commensals within the mammalian intestinal tract. Like Serratia, they have been frequently documented as ...
ID A8AL20_CITK8 Unreviewed; 327 AA. AC A8AL20; DT 23-OCT-2007, integrated into UniProtKB/TrEMBL. DT 23-OCT-2007, sequence version 1. DT 27-SEP-2017, entry version 56. DE RecName: Full=2-keto-3-deoxygluconate permease {ECO:0000256,HAMAP-Rule:MF_00070}; DE Short=KDG permease {ECO:0000256,HAMAP-Rule:MF_00070}; GN Name=kdgT {ECO:0000256,HAMAP-Rule:MF_00070}; GN OrderedLocusNames=CKO_03092 {ECO:0000313,EMBL:ABV14183.1}; OS Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Citrobacter. OX NCBI_TaxID=290338 {ECO:0000313,EMBL:ABV14183.1, ECO:0000313,Proteomes:UP000008148}; RN [1] {ECO:0000313,EMBL:ABV14183.1, ECO:0000313,Proteomes:UP000008148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696 RC {ECO:0000313,Proteomes:UP000008148}; RG The Citrobacter koseri Genome Sequencing Project; RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton ...
ID ENTS8_1_PE3859 STANDARD; PRT; 609 AA. AC ENTS8_1_PE3859; A7MMX9; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=Putative uncharacterized protein; (ENTS8_1.PE3859). GN OrderedLocusNames=ESA_04001; OS CRONOBACTER SAKAZAKII ATCC BAA-894. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Cronobacter. OX NCBI_TaxID=290339; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ENTS8_1.PE3859. CC Cronobacter sakazakii ATCC BAA-894 chromosome, complete genome. CC genome. CC -!- ANNOTATIONS ORIGIN:A7MMX9_ENTS8 CC -!- GENE_FAMILY: HOG000258898 [ FAMILY / ALN / TREE ] DR UniProtKB/Swiss-Prot; A7MMX9; -. DR EMBL; CP000783; ABU79187.1; -; Genomic_DNA. DR RefSeq; YP_001440023.1; NC_009778.1. DR ProteinModelPortal; A7MMX9; -. DR SMR; A7MMX9; 2-609. DR STRING; A7MMX9; -. DR GeneID; 5549084; -. DR GenomeReviews; CP000783_GR; ESA_04001. DR ...
In its acceptance letter, the FDA has stated that it is currently planning to hold an advisory committee meeting to discuss this application. The NDA is supported by data from both the EPIC and CARE clinical trials which evaluated the safety and efficacy of plazomicin in patients with serious infections caused by gram-negative pathogens, including extended-spectrum beta-lactamase (ESBL) producing and carbapenem-resistant Enterobacteriaceae (CRE). The FDA granted Breakthrough Therapy designation for plazomicin for the treatment of bloodstream infections (BSI) caused by certain Enterobacteriaceae in patients who have limited or no alternative treatment options. Breakthrough Therapy designation was created by the FDA to expedite the development and review of drugs that target serious or life-threatening conditions. Plazomicin has also received Qualified Infectious Disease Product (QIDP) designation from the FDA which provides incentives for the development of new antibiotics, including priority ...
Authors: Vidhya Vijayakumar, Araceli Santiago, Rachel Smith, Mark Smith, Roy M Robins-Browne, James P Nataro, Fernando Ruiz-Perez
98650 avhandlingar från svenska högskolor och universitet. Avhandling: Antibiotic resistance gone wild A One Health perspective on carriage, selection and transmission of Extended-Spectrum Cephalosporinase- and Carbapenemase-producing Enterobacteriaceae.
Lineage: cellular organisms; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex; Enterobacter cloacae complex Hoffmann cluster IV ...
Although much of the focus of multidrug-resistant organisms has been on MRSA, a relatively new and potentially more dangerous infectious disease has begun to draw attention from infection control regulators. Carbapenem-resistant or carbapenemase-producing Enterobacteriaceae (CRE) have recently emerged as the most common gram-negative bacteria and a challenge for healthcare providers worldwide.
General characters of the family Enterobacteriaceae. •Gram negative rods •Motile or non motile •If motile with peritrichious flagella •Aerobic or facultative anaerobe •Catalase positive •Oxidase negative •Ferment glucose with or without production of gas • Reduce nitrates to nitrites •Morphology gram negative non sporing •Motility •Culture -Simple media they can grow very easily •Why the selective media are used then •To Knock out the normal flora. ...
Diseases caused by bacteria of Enterobacteriaceae family are still an important medical problem, especially in developing countries. The diarrhoea being the result of bacterial infection is the third cause of death among children of up to five years old. Additionally, there is a major problem with antibiotic resistant bacterial strains in developed countries. Therefore, it would be highly beneficial to develop vaccines against opportunistic bacterial pathogens of gastrointestinal system for prevention of Enterobacteriaceae infections.. ...
Besides the constant care of patients, healthcare facilities have one more thing on their hands: the CRE (carbapenem-resistant Enterobacteriaceae) bacteria. This lethal enemy is unfortunately growing to be very common in intensive care settings to the point that there is an alert rising due to this.
On the right plate, carbapenem-resistant Enterobacteriaceae is able to grow even in the presence of antibiotics. Photo by CDC A ...
Canterbury District Health Board (CDHB) said that three people tested positive as potential carriers of Carbapenem-resistant Enterobacteriaceae (CRE).
Brink, Adrian et al. The spread of carbapenem-resistant Enterobacteriaceae in South Africa: Risk factors for acquisition and prevention. SAMJ, S. Afr. med. j., July 2012, vol.102, no.7, p.599-601. ISSN 0256- ...
Sigma-Aldrich offers abstracts and full-text articles by [G Amicosante, A Oratore, N Franceschini, M Maccarrone, R Strom, M Galleni, J M Frère].
Ceftibuten-Avibactam Activity against β-Lactam-Resistant Enterobacteriaceae Clinical Isolates. Lead author LR Duncan, presented at ASM Microbe 2019, June 20-24, San Francisco, CA, ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Hariharan, H., & Barnum, D. A. (1973). Drug resistance among pathogenic Enterobacteriaceae from animals in Ontario. Canadian Journal Of Public Health, 64(1), 69 ...
API 20EIdentification System for Enterobacteriaceae and other Gram Negative Rods.1.The culture that I was given was culture B. The 7-digit numerical profile of my organism was 3604132. This organism is known as citrobater freudndii.2.Escherichia.Escher...
Steyn, D. G. Finlayson, M. H. Brede, H. D. 1976. The Enterobacteriaceae of South African Baboons. South African Medical Journal, 19 June: 994- ...
This study aimed to investigated the prevalence and resistance pattern of different Citrobacter species phenotypically and genotypically to β-lactam and some most common antibiotics then evaluate the antibacterial activity of omega-3 extracted from flaxseed against isolates that harboring resistance genes. 19 Citrobacter isolates were isolated from100 stool and urine samples taken from patients attended to AL-Sadar Hospital during June-December 2016. Clinical samples were cultured on specific media, thereafter isolates were identified depending on morphological, biochemical characteristics and VITK-2. The results showed that the Citrobacter comprise 24% of isolated bacteria which divided into 11 (14.1%) were C. freundii, 5 (6.41%) C. kosaeri and C. farmeri were 3 (3.8%). The antagonistic activity was evaluated by observing a clear zone of inhibition growth, the results showed that all Citrobacter (100%) isolates were resistant to Ampicillin, cefoxitin and sensitive to Imipinim, also the ...
Vu, H, and H Nikaido. "Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams.." Antimicrobial Agents and Chemotherapy 27.3 (1985): 393-398. Web. 04 July. 2020. ...
The objective of this study was to assess the prevalence of maternal recto-vaginal ESBL-E colonization, identify risk factors for maternal and neonatal ESBL-E c...
Escherichia coli and other species of Enterobacteriaceae producing CTX-M type extended-spectrum beta-lactamases (ESBLs) have been reported from a number of European countries
General Information: Rahnella aquatilis is a facultatively anaerobic, nitrogen-fixing, gram-negative rod from the Enterobacteriaceae family. It is usually found in fresh water. It is sometimes found in human clinical specimens. ...
words that start with enterobacteria, words starting with enterobacteria, words that begin with enterobacteria, words beginning with enterobacteria
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Hi all, I live in the southeastern part of the US, and we are beginning to see more and more patients with ESBL infections- all that I know of have been of the E. Coli type. Are you seeing an
MMWR June 22, 2012 V.61 N.24 P.446-448 U.S. and international efforts to control carabapenem-resistant Enterobacteriaceae (CRE) are critical to protect public health. Clinicians caring for patients infected with such organisms have few, if any, therapeutic options available. CRE containing New Delhi metallo-beta-lactamase (NDM), first reported in a patient who had been hospitalized in New Delhi,…
TY - JOUR. T1 - Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions. AU - Wine, Eytan. AU - Shen-Tu, Grace. AU - Gareau, Melanie. AU - Goldberg, Harvey A.. AU - Licht, Christoph. AU - Ngan, Bo Yee. AU - Sorensen, Esben S.. AU - Greenaway, James. AU - Sodek, Jaro. AU - Zohar, Ron. AU - Sherman, Philip M.. PY - 2010/9. Y1 - 2010/9. N2 - Although osteopontin (OPN) is up-regulated in inflammatory bowel diseases, its role in disease pathogenesis remains controversial. The objective of this study was to determine the role of OPN in host responses to a non-invasive bacterial pathogen, Citrobacter rodentium, which serves as a murine infectious model of colitis. OPN gene knockout and wild-type mice were infected orogastrically with either C. rodentium or Luria-Bertani (LB) broth. Mouse-derived OPN+/+ and OPN-/- fibroblasts were incubated with C. rodentium and attachingeffacing lesions were demonstrated using transmission electron ...