The 2022 Gordon Research Conference on Environmental Endocrine Disruptors will be held in Newry, ME. Apply today to reserve your spot.
Concern that selected chemicals in the environment may act as endocrine active compounds in aquatic ecosystems is widespread; however, few studies have examined the occurrence of endocrine active compounds and identified biological markers of endocrine disruption such as intersex occurrence in fish longitudinally in a river system. This report presents environmental data collected and analyzed by the U.S. Geological Survey, Minnesota Pollution Control Agency and St. Cloud State University as part of an integrated biological and chemical study of endocrine disruption in fish in the Mississippi River. Data were collected from water, bed sediment, and fish at 43 sites along the river from the headwaters at Lake Itasca to 14 miles downstream from Brownsville, Minnesota during June through August 2006. Twenty-four individual compounds were detected in water samples, with cholesterol, atrazine, N,N-diethyl-meta-toluamide, metolachlor, and hexahydrohexamethylcyclopentabenzopyran detected most ...
Endocrine-disrupting chemicals (EDCs) substantially cost society as a result of increases in disease and disability but-unlike other toxicant classes such as carcinogens-have yet to be codified into regulations as a hazard category. This Series paper examines economic, regulatory, and policy approaches to limit human EDC exposures and describes potential improvements. In the EU, general principles for EDCs call for minimisation of human exposure, identification as substances of very high concern, and ban on use in pesticides. In the USA, screening and testing programmes are focused on oestrogenic EDCs exclusively, and regulation is strictly risk-based. Minimisation of human exposure is unlikely without a clear overarching definition for EDCs and relevant pre-marketing test requirements. We call for a multifaceted international programme (eg, modelled on the International Agency for Research in Cancer) to address the effects of EDCs on human health-an approach that would proactively identify ...
In 2000, the U.S. Environmental Protection Agency (EPA) nominated four types of in vitro test methods for ICCVAM to review. These test methods were proposed for use in the EPA Endocrine Disruptor Screening Program.. NICEATM gathered relevant data and prepared a review document of the four types of tests. An independent expert panel review concluded that there were no adequately validated in vitro endocrine disruptor screening tests.. ICCVAM considered the panels conclusions and recommendations, along with comments from the public, as it developed its final test method evaluation report.. ...
EFSA is currently involved in a number of initiatives to develop scientific knowledge in the field of endocrine active substances and also on overlapping issues such as non-monotonic dose-response relationships and biological relevance in risk assessment. This work follows up on a 2013 scientific opinion by EFSA which provided a definition of endocrine disruptors.
Burgeoning epidemiological, animal, and cellular data link environmental endocrine-disrupting chemicals (EDCs) to metabolic dysfunction. Disproportionate exposure to diabetes-associated EDCs may be an underappreciated contributor to disparities in metabolic disease risk. The burden of diabetes is no …
The evaluation of endocrine active substances is currently under discussion. EU legislation demands extensive consequences for endocrine disruptors: biocides and pesticides containing endocrine disruptive substances may not be placed on the market. Endocrine active substances may be placed on the candidate list for authorisation on a case-by-case basis in the context of REACH. Currently, no standardised definition or evaluation criteria for endocrine disruptors exist in the EU. The previous goal to elaborate such criteria untill the end of 2013 has been postponed till October 2014. Endocrine disruptors and regulatory consequences are the topic of the next Advanced Course in Toxicology of the Working Group Regulatory Toxicology of the German Society of Toxicology (DGPT). This course takes place on 31 March 2014 as satellite activity of the annual conference of the DGPT in Hannover. FoBiG is presenting results of an actual project. You find the program and the registration form for the course ...
Objectives We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case-control study from nine European countries.. Methods After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure.. Results The overall exposure prevalence to EDC was low reaching a maximum of 11% for ...
Endocrine-disrupting chemicals (EDCs)-such as BPA-can show tangible effects on health endpoints at high dosage levels, yet those effects do not predict how EDCs will affect the endocrine system at low doses, according to a recent study accepted for publication in The Endocrine Societys Endocrine Reviews.
Department of Public Health - Institute of Environmental and Occupational Medicine, Department of Public Health, Health, Aarhus ...
The development of the male reproductive system requires the action of different hormones and is highly susceptible for development to be altered due to endocrine disruptions. Cryptorchidism is the failure of descent of the testis and is the most common congenital malformation in males. Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are some of the most widely used drugs used. These drugs have recently been identified as potential endocrine disruptors (ED) in humans. A number of epidemiological studies have reported that exposure to NSAIDs and analgesics during pregnancy showed an increased risk of cryptorchidism. This study used 62 fetuses from the first trimester between 7-12 weeks in gestation (GW) from pregnant women who obtained an abortion legally and with were given information and verbal consent was obtained according to national guidelines. The terminations were not motivated by abnormalities. The testes were cut in approximately 1mm3 pieces and drugs were used in the ...
The development of the male reproductive system requires the action of different hormones and is highly susceptible for development to be altered due to endocrine disruptions. Cryptorchidism is the failure of descent of the testis and is the most common congenital malformation in males. Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are some of the most widely used drugs used. These drugs have recently been identified as potential endocrine disruptors (ED) in humans. A number of epidemiological studies have reported that exposure to NSAIDs and analgesics during pregnancy showed an increased risk of cryptorchidism. This study used 62 fetuses from the first trimester between 7-12 weeks in gestation (GW) from pregnant women who obtained an abortion legally and with were given information and verbal consent was obtained according to national guidelines. The terminations were not motivated by abnormalities. The testes were cut in approximately 1mm3 pieces and drugs were used in the ...
Even at very low doses, endocrine-disrupting chemicals (EDCs) that mimic the action of naturally occurring estrogens impair the bodys secretion of glucagon, according to a study.
Youre likely exposing yourself to endocrine-disrupting chemicals if you are eating packaged food, washing your clothes with regular detergent, and more.
This Test Guideline describes the Medaka Extended One Generation Test (MEOGRT), which exposes fish over multiple generations to give data relevant to ecological hazard and risk assessment of chemicals, including suspected endocrine disrupting chemicals (EDCs). Exposure in the MEOGRT starts with spawning fish (P or F0 generation) and continues until hatching (until two weeks post fertilization, wpf) in the second (F2) generation. This Test Guideline measures several biological endpoints. Primary emphasis is given to potential adverse effects on population relevant parameters including survival, gross development, growth and reproduction (fecundity). Secondarily, in order to provide mechanistic information and provide linkage between results from other kinds of field and laboratory studies, where there is a posteriori evidence for a chemical having potential endocrine disrupter activity (e.g. androgenic or oestrogenic activity in other tests and assays) then other useful
The U.S. Environmental Protection Agency (EPA), after much delay, has released a list of potential endocrine disruptors. Included are 73 chemicals, 69 of which are pesticides and 4 are inert and used in pesticides. The effects include endocrine effects, anti-androgenic activity or anti-estrogenic activity. There is concern amongst a number of scientists that many chemicals […]. View Post ...
EDSP FAQs. Overview:. Substances that mimic, influence, or interfere with the bodys endocrine system at certain doses, and produce potentially adverse developmental, reproductive, neurological, and/or immune effects in both humans and wildlife, are called endocrine disruptors. These substances can be naturally-occurring or man-made. Endocrine issues have long been the subject of intense regulatory interest and scientific debate. In the last decade, substances that may have endocrine effects have been subject to increased regulatory attention, and companies making or using these substances must stay keenly abreast of the sometimes murky and controversial legal and scientific developments regarding endocrine disruptors.. The Food Quality Protection Act (FQPA), Federal Food, Drug, and Cosmetic Act (FFDCA), and Safe Drinking Water Act (SDWA) each requires the U.S. Environmental Protection Agency (EPA) to screen pesticides, commercial chemicals, and environmental contaminants to determine whether ...
BKH/European Commission. Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption: - preparation of a candidate list of substances as a basis for priority setting. Final report-November 2000. http://europa.eu.int/comm/environment/docum/01262_en.htm#bkh. Category 1 chemicals from Annex 1: Candidate list of 553 substances. http://europa.eu.int/comm/environment/docum/bkh_annex_01.pdf, Brucker-Davis, F. Effects of Environmental Synthetic Chemicals on Thyroid Function. Thyroid. 8(9): 827-856. 1998., Illinois EPA. Endocrine Disruptors Strategy. 1997. (Table 1: Preliminary List of Chemicals Associated with Endocrine System Effects in Animals and Humans or In Vitro). http://www.nihs.go.jp/hse/environ/illiepatable.htm, Japanese National Institute of Health Sciences. Lists of Paradigmatic Chemicals. http://www.nihs.go.jp/hse/endocrine-e/paradigm/paradigm.html, Keith, L.H. (ed.). Environmental Endocrine Disruptors. John Wiley & Sons, NY. 1997. ...
Endocrine disruptors are exogenous substances that alter the functions of the endocrine system and consequently cause adverse health effects in an intact system, its progeny and the larger population. During the last century, many endocrine disrupting compounds have been synthesised and released into the environment. The production of several of these compounds has been phased out, because of either legislation or voluntary action by the companies that manufacture the compounds. In many cases, this has led to a reduction of exposure in humans and the environment. However, negative health effects might still be present at these lower levels. For several groups of endocrine disruptors, there have been substitutions of one compound for other compounds with similar chemical structure. The toxicity of the newly introduced compounds is often less known than the effect of the one originally used, which can lead to adverse health effects with eventual restrictions of the new compounds. We discuss here ...
Introduction During the last decade, numerous studies have been published, reporting an increase in male reproductive organ anomalies, as well as in testicular cancer, and a decline in the relative number of male births, and in semen quality. At the same time, a growing number of therapeutical as well as environmental chemicals with recognized estrogenic, anti-androgenic or other hormonal activity have been focused on, as being potentially responsible for the mentioned anomalies. Many studies have been carried out, on experimental animals, as well as through observation of exposed human cohorts, in an attempt to gather evidence on the suspected developmental toxicity of these substances, in general referred to as endocrine disruptors. Observed anomalies and trends Sex ratio Sex ratio is measured as the ratio of male to female births, and its normal value, with slight deviations, is considered to be of 1.06, that is 106 males for every 100 females born (Davis et al., 1998). Numerous factors have ...
Environmental exposures to chemically heterogeneous endocrine disrupting chemical substances (EDCs) mimic or hinder hormone activities, and negatively effect human health. Intro The effect of environmental endocrine disrupting chemical substances (EDCs) on human being health is definitely widely talked about, but remains badly understood. By 1011301-27-1 supplier description, EDCs, generally binding to nuclear receptors (NRs), work by interfering with any facet of hormone actions (diabetes, weight problems), fertility, neurological, behavioral (Weiss, 2012) and developmental problems (De Coster and vehicle Larebeke, 2012, Rochester, 2013). The set of potential EDCs can be comprised of a big and growing amount of specific substances or mixtures, and their metabolic/environmental derivatives. These substances have diverse chemical substance structures and so are introduced in to the environment from both organic and industrial resources. As recommended 1011301-27-1 supplier by environmentally ...
Scientists today reported widespread global contamination of sea sand and sea water with the endocrine disruptor bisphenol A (BPA) and said that the BPA probably originated from a surprising source: Hard plastic trash discarded in the oceans and the epoxy plastic paint used to seal the hulls of ships.
That these public policies further should be based on data that comprehensively include both low-level and high-level exposures.. Currently, there is no comprehensive, coordinated approach to regulating EDCs in the U.S. In 1996, Endocrine Disruptors (EDCs) were formally recognized as a public health concern when Congress passed the Food Quality Protection Act (FQPA) and amendments to the Safe Drinking Water Act. Years behind a statutory schedule, in 2009 the U.S. Environmental Protection Agency (EPA) issued its first test orders for screening of dozens of high-priority pesticides for endocrine disrupting effects. The agency subsequently announced that it has expanded its testing and identified a list of chemicals that will be screened for their potential to disrupt the endocrine system, along with a draft of the policies and procedures that the agency has proposed to follow for testing. However, the agency has yet to finalize its procedures or officially test a chemical for endocrine disruption ...
Endocrine disruptors pose a substantial risk to public health, yet the European Commission has dawdled time and again on introducing measures that would finally limit their use. Now is the time to put this right, write Genon Jensen and Michael Warhurst.. Genon Jensen is the Executive Director of the Health and Environment Alliance (HEAL) and Michael Warhurst is the Executive Director of CHEM Trust.. Over twenty years ago, scientists began to be concerned about chemicals that could disrupt our bodys sensitive hormone (or endocrine) system, which are particularly crucial in development and reproduction, also known as endocrine disrupting chemicals (EDCs). In spite of the fact that chemicals with these properties are found in everyday products, the EU still has not agreed the criteria to identify such EDC chemicals.. Without such criteria the people of Europe - and our environment - are not being properly protected and concerns continue to mount in medical and cancer communities and among leading ...
BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.. ...
A newly released report, published in the The Lancet Diabetes & Endocrinology has revealed that exposure to hormone-disrupting chemicals is attributed to $340 billion in health costs each year in the United States.. These endocrine-disrupting chemicals, or EDCs for short, are found in many everyday items that are used in homes across the country. Plastic food containers, detergents, flame retardants, cosmetics and even toys for children can be host to these damaging substances.. Some of the problems related to exposure to EDCs include neurological damage and behavioral problems such as attention deficit/hyperactivty disorder (ADHD), autism and loss of IQ. The report suggests that these issues make up about 80 percent of the problems caused by EDC exposure.. Of course, these are not the only health issues that are caused by EDCs. These chemicals, which are basically toxins, have also been attributed to obesity, diabetes, cancer, male infertility, and endometriosis - a painful condition ...
Research. The focus of my basic science research program is to determine the effects of endocrine disruptors on reproductive cells. Specifically, I study ovarian follicular maturation in the adult and germ cell migration during early embryonic development; both lines of experimentation utilize zebrafish (a vertebrate model heavily used in developmental biology and genetics). Endocrine disruptors (EDs) are prominent in the environment as herbicides, pesticides, plasticizers and numerous other agents. These compounds have been shown to negatively impact both wildlife and human populations, often through binding to steroid receptors. Because of their potential to bind steroid receptors these compounds are particularly disruptive to the tightly controlled mechanisms of neural and reproductive development as well as adult neural, thyroid and reproductive function.. As human females approach menopause there is an increasing chance of conceiving children with chromosomal anomalies such as too many ...
About the Book. This Endocrine Disruptors, Brain and Behavior is edited by Heather B. Patisaul and Scott H. Belcher. This First Edition textbook focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence.. Features. - The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps ...
We all desire health and vitality; theyre the reasons many people commit to a more natural way of living. While you may try to be careful about what you put in your body, have you thought about what youre putting on your body? Our skin absorbs much of what we put on it, so much so that doctors often prescribe medicine to be topically administered.. Did you know that many of the conventional beauty and personal care products we apply to our skin are laden with potentially harmful chemicals that are known to alter your bodys natural cycles and processes?. One of the most threatening of these substances are endocrine disruptors or hormone disruptors. These interfering chemicals are shockingly common and have been associated with numerous health issues, from increased cancer risk to infertility.. Hormone disruptors affect your bodys endocrine system in several ways. Many of these chemicals imitate the natural hormones in your body by decreasing or increasing their production and interfering with ...
This topic contains 76 study abstracts on Endocrine Disruptor chemicals such as Statin Drugs, Organochlorine pesticides, and Simvastatin
Endocrine disrupting chemicals and carcinogens, some of which may not yet have been classified as such, are present in many occupational environments and could increase breast cancer risk. Prior research has identified associations with breast cancer and work in agricultural and industrial settings. The purpose of this study was to further characterize possible links between breast cancer risk and occupation, particularly in farming and manufacturing, as well as to examine the impacts of early agricultural exposures, and exposure effects that are specific to the endocrine receptor status of tumours. 1005 breast cancer cases referred by a regional cancer center and 1146 randomly-selected community controls provided detailed data including occupational and reproductive histories. All reported jobs wereindustry- and occupation-coded for the construction of cumulative exposure metrics representing likely exposure to carcinogens and endocrine disruptors. In a frequency-matched case-control design, exposure
Earlier this year, a landmark paper appeared titled Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses, published in Endocrine Reviews, a journal of the prestigious Endocrine Society. In this 78-page review, supported by 845 references, twelve leading environmental health researchers challenge the dogma of the dose makes the poison, noting that endocrine-disrupting chemicals (EDCs) can have effects at low doses that are not predicted by effects at higher doses, and noting that fundamental changes in chemical testing and safety determination are needed to protect human health. The paper has received much attention. On this call, three of the authors of this paper will summarize their work and responses to it. ...
Dear Reader,. We know that dangerous chemicals like hormone disruptors are found in many products.. Thats why EWG has partnered with the Keep A Breast Foundation to develop our latest report - the Dirty Dozen list of endocrine disruptors.. There is no end to the tricks that endocrine disruptors can play on our bodies: increasing production of certain hormones; decreasing production of others; imitating hormones; turning one hormone into another - and so much more.. Click here to see this list of the dirtiest and most common endocrine disruptors.. The EWG/KAB Dirty Dozen list includes BPA, phthalates and other endocrine disruptors that are widespread in consumer products such as plastic containers, food cans and fragrances. The list also includes common contaminants that many people dont realize can be hormone disruptors, not only those familiar toxins - arsenic, mercury and lead - but other, less familiar chemicals such as glycol ethers and perfluorinated chemicals. The guide is intended for ...
Skinner MK. Growth factor regulation and phenotype sexual differentiation in the female and male fetus. Impact of endocrine disruptors. Presented at the National Institute of Environmental Health Sciences, U.S. Environmental Protection Agency, National Institute of Child Health and Human Development Gender Differences by Reproductive Biology and Toxicology Symposium, Tucson, AZ, November 2000 ...
Fingerprint Dive into the research topics of Pyrethroid pesticides as endocrine disruptors: Molecular mechanisms in vertebrates with a focus on fishes. Together they form a unique fingerprint. ...
Three new studies show that adult disease often originates in the fetus and is tied to endocrine disruptors and environmental toxins such as BPA.
interferenti endocrini (it); perturbateur endocrinien (fr); Hormónaraskandi efni (is); interferent endocrí (ca); Endokrinní disruptory (cs); Endokrine Disruptoren (de); disruptor endócrino (pt); Hormonstörande ämnen (sv); إضطراب الغدد الصماء (ar); 內分泌干擾素 (zh); Hormonforstyrrende stoffer (da); Hormonski motilec (sl); 内分泌攪乱物質 (ja); związki endokrynnie czynne (pl); 내분비계 장애물질 (ko); Endokrinný disruptor (sk); hormonforstyrrande stoff (nn); അന്തഃസ്രാവീസ്വാധീനം (ml); endocriene disruptor (nl); 內分泌干擾素 (zh-hant); 內分泌干擾素 (zh-hk); interruptor endocrino (es); Hormonitoimintaa häiritsevät kemikaalit (fi); endocrine disruptor (en); endokrina perturbanto (eo); 内分泌干扰素 (zh-hans); Chất gây rối loạn nội tiết (vi) 環境中に存在し、生体にホルモン作用を起こす、またはホルモン作用を阻害する化学物質 (ja); hormonähnlich wirkende ...
CHICAGO -- A plasticizer commonly substituted for bisphenol A (BPA) may cause similar endocrine-disrupting effects as the original chemical, researchers reported here.
Abstract: The toxic effect of various environmental contaminants such as heavy metals or industrial chemicals such as alkylphenolson male reproductive systemwasfound. 4-nonylphenol (4-NP), one of the environmental contaminants used in the manufacture of plastics and other products, is released largely into the environment. The majority of studies on NP have focused on their endocrine disrupting and potential adverse effects on reproductive system. The target of our in vitro study was to determine the potential impact of 4-nonylphenol as an endocrine disruptor on the hormonal secretion and viability of mice Leydig cells. Cells were cultured with addition of 0.04; 0.2; 1.0; 2.5; and 5.0 µg/mL of 4-nonylphenol for 44h and compared with the control. Cells destined for the determination of androstenedione production were cultured in the presence of cyclic AMP solution. Quantification of cAMP stimulated androstenedion production directly from aliquots of the medium was performed by enzyme linked ...
Ask our Wellness Educators April 2018 Dear NEEDS Wellness Educators, Q: I was recently diagnosed with a gynecologic problem and went to a doctor for help. This doctor said that I had excess estrogen levels that needed to be lowered. When we reviewed some of the potential causes of excess estrogen, I realized that one source may be from my daily beverages. Every morning, I get a to-go coffee in a Styrofoam cup and I carry around a plastic water bottle all the time. I did some research and learned that chemicals from the plastic and Styrofoam can act like fake estrogen. How does this happen? A: Environmental toxins, coming from a variety of sources, are believed to cause a wide range of health problems in the body. Plastics in particular, leach chemicals that interact with estrogen receptors in the body. These chemicals are also known as Estrogenic Endocrine Disruptors (EEDs). EEDs include chemicals from plastics, such as bisphenol-A (BPA), polychlorinated biphenyls (PCBs), and phthalates, but
The present study examined the influence of endocrine active compounds (endocrine disruptors, ED), which are present in surface waters, on reproductive biology of aquatic organisms. The amphibian Xenopus laevis is a well-established model organism for the study of effects of ED on reproduction. It has been modified and broadened for the purpose of this study, and it was combined with chemical methods for water analyses. It is possible to assess water pollution with ED by detecting effects on repro-ductive biology of one particular substance, and then by looking for this substance in environmental water samples. We showed the feminizing potency of Bisphenol A (BPA) in conducting exposure experiments with tadpoles, in examining histological samples of gonads and in detecting the induction of the expression of a molecular estrogenic biomarker. BPA was recognized to mediate its effects via binding to the estrogen receptor. Moreover, analysis of BPA during exposure experiments revealed that BPA is ...
The guidelines include evidence-based recommendations on how to talk with patients about environmental toxins like lead, mercury, pesticides and other endocrine-disrupting chemicals such as bisphenol A (BPA), which is used in a variety of products including canned food linings and cash register receipts. It also includes resources for each toxin area, outlining an easy and consistent way to deliver these important messages to women and their partners.. The guidelines contain helpful information for patients, too. Women and their partners should be aware that pregnancy is an important time for development, that environmental chemicals can cause harm to a developing fetus, and that this topic is important to discuss with health care providers, said Dr. Sathyanarayana. There are simple ways to reduce exposures to lead, mercury, pesticides and endocrine-disrupting chemicals such as BPA by following the guidelines we have outlined, she said.. Dr. Sathyanarayanas co-authors include: Susan ...
Bisphenol A is back in the headlines this week after a new report found high levels of the endocrine disruptor on 40 percent of receipts from businesses. Lab results from a study commissioned by the Environmental Working Group found thermal paper used by a number of major U.S.
Bisphenol A is back in the headlines this week after a new report found high levels of the endocrine disruptor on 40 percent of receipts from businesses. Lab results from a study commissioned by the Environmental Working Group found thermal paper used by a number of major U.S.
Managing Editors Note: I apologize we missed this post earlier in the week from SafeMinds board member Deirdre Imus on HuffPo. Could Endocrine-Disrupting Chemicals in Vaccines Cause Autism? ...Environmental triggers, including endocrine-disrupting chemicals (EDCs), is an area in which autism...
Study Objectives Characterize the extent of EDC contamination in the Assabet River Characterize EDCs and other CECs* in the effluents from the four major WWTPs on the river Evaluate the impacts of EDCs on fish (minnows) reproductive health (feminization of males) in the river Provide data that informs NPDES permit decisions regarding the need for reductions of inputs of EDCs * CECs = Contaminants of Emerging Concern 3
Scientific experts have outlined the focus on the level of evidence needed to characterise endocrine activity, according to a report from the Joint Research Centre (JRC).
The Daily Mail, rarely prone to scaremongering, leads this morning with a story called Poisoned by everyday life, reporting on a World Health Organisation study which found that chemicals found in every home may be linked to breast cancer, asthma, infertility and birth defects.. The WHO report said it was reasonable to suspect that phthalates - chemicals the Daily Mail labels as gender bending, which are used in toys, PVC flooring, car dashboards and credit cards - have serious implications for health.. The landmark report, called State of the Science of Endocrine-Disrupting Chemicals, said a ban might be needed as the chemicals could harm female fertility and are linked with rising rates of childhood illnesses such as leukaemia.. It said: The diverse systems affected by endocrine-disrupting chemicals likely include all hormonal systems and range from those controlling development and function of reproductive organs to the tissues and organs regulating metabolism and satiety.. Effects ...
TY - JOUR. T1 - Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages. T2 - Involvement of estrogen receptor-dependent or -independent pathways. AU - Yoshitake, Jun. AU - Kato, Katsuaki. AU - Yoshioka, Daisuke. AU - Sueishi, Yoshimi. AU - Sawa, Tomohiro. AU - Akaike, Takaaki. AU - Yoshimura, Tetsuhiko. N1 - Funding Information: This work was supported in part by a Grant-in-Aid to T.Y. for Scientific Research (17550146) from the Japan Society for the Promotion of Science. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2008/5. Y1 - 2008/5. N2 - Since the endocrine and immune systems share portions of some intracellular signaling pathways, endocrine-disrupting chemicals (EDCs) are considered potential agents for influencing inflammatory responses. Here, we investigated the effect of EDCs on lipopolysaccharide (LPS)-induced NO production and NF-κB activation in the RAW264.7 mouse macrophage ...
TY - JOUR. T1 - Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. AU - Vrijheid, M. AU - Armstrong, B. AU - Dolk, Helen. AU - van Tongeren, M. AU - Botting, B. PY - 2003. Y1 - 2003. U2 - 10.1136/oem.60.8.543. DO - 10.1136/oem.60.8.543. M3 - Article. VL - 60. SP - 543. EP - 550. JO - Occupational and Environmental Medicine. JF - Occupational and Environmental Medicine. SN - 1351-0711. IS - 8. ER - ...
Single Center, Therapeutic Exploratory Clinical Trial to Evaluate the Safety of Sodium Oxybate (Xyrem) 500 mg/mL Oral Solution on Potential Endocrine Changes at Currently Labeled Therapeutic Dose Regimens (4.5 - 9 g/Day Divided Into Two Equal Doses) During 12 Weeks of Treatment of Cataplexy in Adult Patients With Narcolepsy ...
At 4:47 pm we are told the observed endocrine disruptor activity from CHDM reactions should be asrcibed to generic and unspecified reaction products of any substance that can be hazardous.. At 9:58 pm we are told from the same source that observed endocrine disruptor activity is due to a very specific esterification process with a specific reagent.. At 3:03 AM I specifically addressed the prospect that observed endocrine disruptor activity from HPAA among the reaction products must specifically excluded. Oddly enough, that mechanism didnt seem to merit at 4:47 PM, but assumed central importance five hours later. This continually moving causal explanation is highly consistent with the goal of denying possible toxicity - and intellectually incoherent.. The data set has not changed in those five hours: the rationale for dismissal of potential endocrine disruptor activity has jumped around a fair bit. Qui bono?. The cited report clearly indicates that HPAA was independently assayed for ED ...
Nuclear Pregnane X Receptor (PXR) is involved in the regulation of drug-metabolism enzymes and therefore plays an essential role in the detoxification pathways. Recent studies have shown that PXR can be activated by exogenous environmental xenobiotics such as pesticides, polychlorinated biphenyls, brominated flame retardants, phyto and myco-estrogens and many more. We measured PXR activity in samples from wastewater treatment and surface water. However, due to the capacity of PXR to bind a multitude of different types of environmental pollutants, it is difficult to predict which type of molecule is responsible for the observed activity in environmental samples. The development of a tool to purify PXR ligands in an environmental complex matrix such as wastewater and sludge should improve their chemical detection. We already developed a recombinant ER alpha affinity column for the purification of estrogenic compounds from water and sediment extracts. In the same way we developed a procedure with
This story, published on 5 September, has been updated to make clear the Commissions draft criteria referred to biocidal products. Below is the updated story.. EU national representatives adopted on Monday (4 September) the European Commissions draft criteria for endocrine disruptors in biocidal products, laying the foundation for a comprehensive strategy to limit citizens exposure to harmful substances.. The EU voted to ban endocrine disruptors in 2009. But so far the ban has not come into effect due to a lack of criteria defining the chemicals that it should cover.. Endocrine disruptors are chemical substances that are suspected of triggering diseases such as cancer or diabetes and contributing to people becoming overweight or infertile through changes to the endocrine (or hormone) system.. They are commonly found in everyday plastic products, food packaging and agricultural chemicals and can be absorbed by the body in a number of ways.. Mondays vote was the first step in the EUs adoption ...
NutritionFacts.org, by Michael Greger: In 1979, an epidemic of breast enlargement was noted in Italian children. Poultry or veal was suspected, given that estrogens may be fed to farm animals to accelerate their weight gain. After this episode, the European Union banned the application/use of anabolic growth promoters in agriculture, as well as the importation of American meat from animals injected with drugs like Zeranol, sold as Ralgro Magnum.. Zeranol, one of the most potent known endocrine disrupters, is 100,000 times more estrogenic than the plastics chemical, BPA, for example, and is the subject of my video Zeranol Use in Meat and Breast Cancer. Zeranol constitutes a special case among potential endocrine disrupters, because Zeranol, in contrast to all other oestrogenic endocrine disrupting chemicals, is present in human food because it is deliberately used in the production of consumer products. Furthermore, Zeranol is designed to be a potent, fairly persistent [estrogen] whereas ...
The main objective of this research project is to understand how in utero Bisphenol A (BPA) exposure affects fetal gonadal development and reproduction in adulthood in mice. In utero exposure to estrogenic endocrine disruptors such as diethylsfilbestrol (DES) is known to cause sex organ malformation, reproductive carcinogenesis, and fertility defects in both male and female in humans and rodents. Based on DES studies, it is proposed that in utero exposure to other endocrine disruptors, particularly those that work through estrogen receptors, may lead to reproductive diseases in adulthood. BPA, a chemical used in synthesis of plastics, exhibits estrogenic activities and deleterious effects on reproduction when given to adult rodents. BPA is detected in serum of pregnant women, umbilical cord blood, and fetal plasma, indicating that developing fetuses are exposed to BPA. Although effects of BPA on adult reproductive organs have been studied extensively, impacts of in utero BPA exposure ...
Increased exposure of birds to endocrine disrupting compounds has resulted in developmental and reproductive dysfunctions. We have recently identified the flame retardants, ally1-2,4,6-tribromophenyl ether (TBP-AE), 2-3-dibromopropy1-2,4,6-tribromophenyl ether (TBP-DBPE) and the TBP-DBPE metabolite 2-bromoallyI-2,4,6-tribromophenyl ether (TBP-BAE) as antagonists to both the human androgen receptor (AR) and the zebrafish AR. In the present study, we aimed at determining whether these compounds also interact with the chicken AR. In silico modeling studies showed that TBP-AE, TBP-BAE and TBP-DBPE were able to dock into to the chicken AR ligand-binding pocket. In vitro transfection assays revealed that all three brominated compounds acted as chicken AR antagonists, inhibiting testosterone induced AR activation. In addition, qRT-PCR studies confirmed that they act as AR antagonists and demonstrated that they also alter gene expression patterns of apoptotic, anti-apoptotic, drug metabolizing and amino ...
Endocrine disrupting chemicals (EDC) are compounds that alter the normal functioning of the endocrine system of both wildlife and humans. A huge number of chemicals have been identified as endocrine disruptors, among them several pesticides. Pesticides are used to kill unwanted organisms in crops, public areas, homes and gardens, and parasites in medicine. Human are exposed to pesticides due to their occupations or through dietary and environmental exposure (water, soil, air). For several years, there have been enquiries about the impact of environmental factors on the occurrence of human pathologies. This paper reviews the current knowledge of the potential impacts of endocrine disruptor pesticides on human health.
Learn about the role endocrine-disrupting chemicals (EDCs) may have on the metabolism and how they may be contributing to the obesity epidemic from the Endocrine Society.
Pesticide formulations contain declared active ingredients and co-formulants presented as inert and confidential compounds. We tested the endocrine disruption of co-formulants in six glyphosate-based herbicides (GBH), the most used pesticides worldwide. All co-formulants and formulations were comparably cytotoxic well below the agricultural dilution of 1% (18-2000 times for co-formulants, 8-141 times for formulations), and not the declared active ingredient glyphosate (G) alone. The endocrine-disrupting effects of all these compounds were measured on aromatase activity, a key enzyme in the balance of sex hormones, below the toxicity threshold. Aromatase activity was decreased both by the co-formulants alone (polyethoxylated tallow amine-POEA and alkyl polyglucoside-APG) and by the formulations, from concentrations 800 times lower than the agricultural dilutions; while G exerted an effect only at 1/3 of the agricultural dilution. It was demonstrated for the first time that endocrine disruption by GBH
Glucocorticoid signaling plays a critical role in regulating energy metabolism. Emerging data implicate environmental endocrine-disrupting chemicals as contributors to the obesity and diabetes epidemics. Previous studies have shown that the phenylsulfamide fungicide tolylfluanid (TF) augments glucoc …
① Water tanks breeding Medaka ② Medaka pair ( ♂ 1 - ♀ 1or2 ) ③ Collect fertilized eggs every morning. ⑥ Observe the embryos under stereo-microscope. ④ Incubate the eggs in an incubato r for 24 hours at 26±0.5 ℃. On the next day, remove dead eggs. Method of egg collection and observation ⑤ Settle the eggs into each well of a microtiter plate wit h 200 m l of dioxin solution. ⑦ RNA extraction ⑧ Quantitative RT- PCR
This article discusses work from the Blumberg laboratory about how the endocrine disruptor, tributyltin alters lineage commitment in mesenchymal stem cells to promote the adipose lineage that was published in the October, 2017 issue of Endocrinology ...
Developmental toxicity of 4-octylphenol (OP), an estrogenic endocrine disruptor was verified using frog embryo teratogenesis assay Xenopus. LC50, EC50Malformtion and EC50Melanocyte-dysgenesis of OP were 9.9, 10.5, and 2.4 μM, respectively. In tadpoles, despite the low teratogenic index, 2 μM OP significantly inhibited head cartilage development and tail malformation. The total length of tadpole was significantly increased at 5 μM and decreased at 10 μM OP. In OP-treated tadpoles, head cartilages were frequently missed and col2a1 mRNA was decreased at 2 μM, indicating a chondrogenic defect in developing head. In the head skin of 1 μM OP-treated tadpoles, number of melanocytes and melanogenic pathway genes expression were significantly decreased. In the head-neck junction of stage 22 embryos, OP increased foxd3 and sox10 mRNA and SOX10(+) neural crest cells (NCCs) in somite mesoderm and endoderm, indicating the inhibition of chondrogenic differentiation, ectopic migration to endoderm, and ...
Dr Hausers research interests are in the fields of reproductive, perinatal and pediatric epidemiology. His research focuses on the impact of environmental chemicals on fertility, pregnancy outcomes and childrens health. He is currently conducting a NIH funded study on the effects of chemicals classified as endocrine disruptors on male and female reproductive health endpoints. Examples of specific chemicals of interest include persistent compounds (i.e., flame retardants, PCBs and DDT), and non-persistent chemicals including pesticides, phthalates, parabens and bisphenol A. Health endpoints of interest include infertility and pregnancy outcomes such as early pregnancy loss, stillbirth, and measures of fetal growth. Male health endpoints of interest include semen quality and sperm DNA damage, as well as the paternal contribution to adverse pregnancy outcomes. The study is being conducted in collaboration with physicians and staff from the Massachusetts General Hospital, Harvard Medical ...
San Francisco - Researchers have successfully induced hypospadias in mice, an accomplishment that observers say provides more compelling evidence in support of the endocrine disruptor hypothesis as an explanation for the increase in hypospadias observed over the past 30 years.
Belfast Free Library, 106 High St. Endocrine Disruptors in Aquatic Ecosystems: What can hormones tell us about the health of Maines aquatic environment? Dr. Heather Hamlin, UMaine Department of Marine Biology and Aquaculture, investigates how human-induced changes affect the reproduction and development of aquatic animals, and solutions to promote resilience of Maines aquatic resources.. ...
Join this webinar series to learn whats new to the guideance detailing the assessment of endocrine disruptors and how it applies to you.
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Chiara Frazzoli and Alberto Mantovani from Istituto Superiore di Sanità share insights into endocrine disruptors and non-communicable diseases in Africa
Green Guidance Hormone-Altering Chemicals in Everyday Products Androgyny on the fashion runway is one thing, but in the Arctic no one wants to see gender-confused polar bears. Yet according to scientists, one in 67 female polar bears in Svalbard, Norway, has developed a stunted penis. The suspected cause is exposure to endocrine-disrupting chemicals, particularly polychlorinated biphenyls (PCBs). Elsewhere, the chemicals have been linked to female mollusks growing penises, fish bearing both sex organs, and reproductive difficulties among mammals. In humans, breast milk contaminated with phthalate plasticizers has been shown to alter hormone levels in three-month-old boys, resulting in incomplete virilization. With 966 known or suspected endocrine-disrupting chemicals in existence-and often in the environment-elimination is unlikely. The European Unions new REACH legislation, which requires that manufacturers find substitutes for the most dangerous of the chemicals in consumer products, will ...
June 26, 2012 /Press Release/ -- A lifestyle that features fresh foods and limited use of products likely to contain environmental chemicals has been shown to reduce exposure to endocrine-disrupting chemicals (EDCs)C such as BPA and phthalates, in a small population study. EDCs are linked to a number of adverse health complications including neuro-developmental delays, behavioral issues and fertility problems. They are produced by the millions of pounds per year and found extensively in a range of products that contain certain plastics.. Researchers from Mount Sinai School of Medicine and University of Rochester School of Medicine and Dentistry examined individual behavioral choices and community lifestyle practices, as well as analyzed urine samples, from a group of Old Order Mennonite (OOM) women in mid-pregnancy and determined that they have lower levels EDCs in their systems than the general population. The study is published online today in the journal NeuroToxicology.. Bisphenol A (BPA) ...
Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction (Dietert et al. 2010). Mounting epidemiological evidence suggests that proper function of the immune system is a major determinant of health across the life course (Dietert et al. 2010). For example, those with childhood asthma may have an elevated risk of developing lung cancer (Dietert et al. 2010), and among individuals ≥ 87 years old, immune dysregulation has been linked with dementia (Katsel et al. 2009). Exposure to environmental toxicants, therefore, may cause life-long changes in response to infectious agents, in immune homeostasis, and in overall physical and mental health (Dietert et al. 2010).. One group of environmental toxicants affecting immune system function is endocrine-disrupting compounds (EDCs) (Chalubinski and Kowalski 2006). In 1996, the U.S. Congress first recognized EDCs as a public health concern when it mandated that ...
Human nuclear receptors control the expression of genes in response to the binding of small signalling molecules in the body. Many compounds that are in the environment are classed as endocrine-disrupting chemicals as they are thought to directly bind nuclear receptors and change gene expression patterns, leading to harmful physical effects. While many of these compounds are harmless individually, the body is constantly exposed to mixtures of these compounds in the environment. It has long been known that combinations of these chemicals can have additive, antagonistic or synergistic effects, but there has been no understanding of the molecular basis for these effects.. The teams of Patrick Balaguer and William Bourguet of INSERM, CNRS and the University of Montpellier used extensive screening methods and biophysical characterisation to identify two endocrine-disrupting chemicals that act synergistically on a human nuclear receptor, the pregnane X receptor (PXR). The two compounds identified are ...
Advances in Epidemiology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of epidemiology.
Abstract Background Renal kallikrein (KLK1) synthesis and urinary excretion are reportedly diminished during AKI (acute kidney injury) in animal models, and provision of kallikrein abrogates renal injury in this setting, but data in human AKI is limited. Therefore we first examined KLK1 renal excretion in human AKI, and then probed potential endocrine and epigenetic mechanisms for its alterations. Methods KLK1 enzymatic activity excretion was evaluated in urine from patients with established or incipient AKI, versus healthy/non-hospital as well as ICU controls. Endocrine control of KLK1 excretion was then probed by catecholamine and aldosterone measurements in established AKI versus healthy controls. To examine epigenetic control of KLK1 synthesis, we tested blood and urine DNA for changes in promoter CpG methylation of the KLK1 gene, as well as LINE-1 elements, by bisulfite sequencing. Results Patients with early/incipient AKI displayed a modest reduction of KLK1 excretion, but unexpectedly, ...
Abstract Background Renal kallikrein (KLK1) synthesis and urinary excretion are reportedly diminished during AKI (acute kidney injury) in animal models, and provision of kallikrein abrogates renal injury in this setting, but data in human AKI is limited. Therefore we first examined KLK1 renal excretion in human AKI, and then probed potential endocrine and epigenetic mechanisms for its alterations. Methods KLK1 enzymatic activity excretion was evaluated in urine from patients with established or incipient AKI, versus healthy/non-hospital as well as ICU controls. Endocrine control of KLK1 excretion was then probed by catecholamine and aldosterone measurements in established AKI versus healthy controls. To examine epigenetic control of KLK1 synthesis, we tested blood and urine DNA for changes in promoter CpG methylation of the KLK1 gene, as well as LINE-1 elements, by bisulfite sequencing. Results Patients with early/incipient AKI displayed a modest reduction of KLK1 excretion, but unexpectedly, ...
Obesity is a worldwide pandemic that also contributes to the increased incidence of other diseases such as type 2 diabetes. Increased obesity is generally ascribed to positive energy balance. However, recent findings suggest that exposure to endocrine-disrupting chemicals such as obesogens during critical windows of development, may play an important role in the current obesity trends. Several experimental approaches, from in vitro cell cultures to transgenerational in vivo studies, are used to better understand the mechanisms of action of obesogens, each of which contributes to answer different questions. In this review, we discuss current knowledge in the obesogen field and the existing tools developed in research laboratories using tributyltin as a model obesogen. By understanding the advantages and limitations of each of these tools, we will better focus and design experimental approaches that will help expanding the obesogen field with the objective of finding potential therapeutic targets in human
Endocrine disruptors are chemicals that can obstruct with endocrine systems at certain doses. These disruptions can cause tumoroustumors, birth defects, and other developmental disorders. Any system in the body well-ordered by hormones can be derailed by hormone disruptors. Specifically, endocrine disruptors may be associated with the development of learning disabilities, severe attention deficit disorder, perceptive and brain development problems deformations of the body that includes breast cancer, prostate cancer, thyroid and other cancers; sexual development problems for example feminizing of males or masculinizing effects on females, etc.. ...
It is prudent to avoid the use of dietary supplements of L-glutamic acid by pregnant women, infants, and children. The existence of evidence of potential endocrine responses, i.e., elevated cortisol and prolactin, and differential responses between males and females, would also suggest a neuroendocrine link and that supplemental L-glutamic acid should be avoided by women…. ...
7/7/2015; Freshwater ecosystems play a central role in the environment. Through various processes such as nutrient recycling, groundwater recharging, and the attenuation of many pollutants these biological systems help to maintain environmental health. Unfortunately, many recent studies have identified emerging threats to these special environments and the life they sustain. One source of mounting concern is a group of compounds that interact with the endocrine systems of humans and wildlife. Known as endocrine disrupting chemicals (EDCs), these natural and synthetic chemicals may mimic or interfere with the action of natural hormonesâ€Âthus disrupting the endocrine system. Multiple studies have reported negative effects associated with EDCs on both the health of humans and wildlife; however more information is needed on the reproductive effects that EDCs may pose to wildlife, in particular fish inhabiting these freshwater ecosystems. Fish serve as a useful indicator of the health of an ...
We evaluated the utility of whole embryo culture for the screening technique of the potency of endocrine active chemicals in rat embryos. Rat embryos on embryonic day 11 (ED11) were exposed to two estrogenic chemicals, estradiol benzoate (EB) and diethylstilbestrol (DES), for 42 hr in culture. The treated embryos showed some morphological defects in the cardiovascular system, such as edema around umbilical vessels (EB- and DES-treated groups), enlargement of the heart (EB) and hemorrhage of the head (DES) at high doses. To determine the mediation of estrogen receptors to these morphological defects, we also studied the expression of estrogen receptor a (ER-a) in embryos both by immunohistochemistry and by Western blotting. Immunohistochemistry revealed positive grains stained with anti-ER- a antibody in both the cytoplasm and nucleus of heart and yolk sac in EDs 12 and 13 rat embryos. The staining pattern of anti-ER-a antibody in embryos was different from the positive control, the uterus of ...
I received my PhD from City University of Hong Kong in 2002. After my postdoctoral training with Prof. Rudolf Wu, I continued to work in the same institution as a Lecturer until joining the University of Newcastle in 2009. I am now an academic in the Discipline of Environmental Science and Management in the School of Environmental & Life Sciences (SELS).. My primary research interests are in the Molecular Toxicology of Environmental Stressors and Chemicals. In particular, I am interested in (1) understanding the molecular mechanisms of endocrine disruption caused by hypoxia and environmental chemicals and (2) developing cell- and animal-based assays for the screening and detection of endocrine-disrupting chemicals (EDCs). Overall, my research covers both basic science aimed at understanding the fundamental mechanisms of environmental toxicity and applied science concerned with the development of diagnostic tools for assessing and monitoring environmental toxicity. Outlined below is a summary of ...
I received my PhD from City University of Hong Kong in 2002. After my postdoctoral training with Prof. Rudolf Wu, I continued to work in the same institution as a Lecturer until joining the University of Newcastle in 2009. I am now an academic in the Discipline of Environmental Science and Management in the School of Environmental & Life Sciences (SELS).. My primary research interests are in the Molecular Toxicology of Environmental Stressors and Chemicals. In particular, I am interested in (1) understanding the molecular mechanisms of endocrine disruption caused by hypoxia and environmental chemicals and (2) developing cell- and animal-based assays for the screening and detection of endocrine-disrupting chemicals (EDCs). Overall, my research covers both basic science aimed at understanding the fundamental mechanisms of environmental toxicity and applied science concerned with the development of diagnostic tools for assessing and monitoring environmental toxicity. Outlined below is a summary of ...
For REACH substances, inclusion in the list means that an informal hazard assessment for endocrine-disrupting properties either is under development or has been completed since the start of the implementation of the SVHC Roadmap in February 2013. For each substance, the table shows the assessing or evaluating Member State (submitter), the outcome and the suggested follow-up for the assessment, and the date of the latest update to the list entry. Other process details and hazard assessment outcome documents are also available and can be accessed through the Details icon. One possible outcome of such an assessment is that a substance is considered not to have ED properties. If the outcome is that the substance is considered to have ED properties, confirmation through the formal risk management and decision-making processes under REACH/BPR is needed before any regulatory action can be taken due to these properties. The intentions of authorities to submit a dossier to the formal REACH and CLP ...
Endocrine Disrupting Chemicals (EDCs) are synthetic compounds that alter hormone systems and can cause adverse health effects. Learn more here.
Today the S&D Group won an important battle for European citizens health, despite opposition from conservative MEPs in the European Parliament
ROCK SPRINGS, Pa. - With water quality in the Chesapeake Bay suffering from excess nutrients and fish populations in rivers such as the Susquehanna experiencing gender skewing and other reproductive abnormalities, understanding how to minimize runoff of both nutrients and endocrine-disrupting compounds from farm fields after manure applications is a critical objective for agriculture.. A new study by researchers in Penn States College of Agricultural Sciences shows that applying manure to crop fields by means of shallow disk injection into the soil rather than traditional surface broadcast significantly reduces estrogens in surface runoff. This finding suggests that manure-application methods can be used to control the mobilization potential of estrogens and points to opportunities for protecting downstream water quality.. The research, published this month in Agriculture, Ecosystems and Environment, also investigated how manure-application methods affected runoff of total dissolved phosphorus ...
The recently developed female leukophore-free (FLFII) strain of Japanese medaka (Oryzias latipes) carries DNA markers for the identification of genotypic sex. Information regarding genotypic sex is useful for tests in which endocrine-disrupting compounds may masculinize or feminize fish. In the present study, methods were developed to automate DNA extraction and profiling for rapid determination of genotypic sex. Adequate amounts of DNA were isolated by robotic extraction procedures from the caudal fin. New primers were developed to include an 18-base pair segment that is in the X chromosome of female medaka but is absent in the Y chromosome of male medaka. Automated profiling methods with 96-well plates permitted analysis of the genomic sex of medaka at rates of up to 500 fish/d. We investigated the sensitivity of the FLFII strain to the feminizing effects of the potent estrogen 17beta-estradiol (E2), and we compared this sensitivity to that of a wild strain that has been used widely in the ...
Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. It is present in a variety of products used daily including food containers, paper, and dental sealants and is now widely detected in human urine and blood. Exposure to BPA during development may affect brain organization and behavior, perhaps as a consequence of its actions as a steroid hormone agonist/antagonist and/or an epigenetic modifier. Here we show that BPA produces transgenerational alterations in genes and behavior. Female mice received phytoestrogen-free chow with or without BPA before mating and throughout gestation. Plasma levels of BPA in supplemented dams were in a range similar to those measured in humans. Juveniles in the first generation exposed to BPA in utero displayed fewer social interactions as compared with control mice, whereas in later generations (F2 and F4), the effect of BPA was to increase these social interactions. Brains from embryos (embryonic d 18.5) exposed to BPA had lower gene ...
Statistical Methods Development & Visual Analytics. [Vignette: Reif et al (2010) Environmental Health Perspectives]. The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery of 467 in vitro, high-throughput screening assays to assess 309 environmental chemicals. One important mode of action leading to toxicity is endocrine disruption, and the U.S. EPAs Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife. The goal of this study was to develop a flexible method to facilitate the rational prioritization of chemicals for further evaluation and demonstrate its application as a candidate decision-support tool for EDSP. Focusing on estrogen, androgen, and thyroid pathways, we defined putative endocrine profiles and derived a relative ...
This work is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of biologically-based risk assessment, as developed form physiologically-based toxicokinetic models. The analysis of this material is proposed as the novel parameters for developing biologically-based models of carcinogenesis, considered to be more relevant to risk assessment than traditional approaches.
The effects of endocrine disruptors can be strongest during critical periods such as fetal development, infancy, adolescence, conception and pregnancy. These are times of important changes that will have long-term consequences for a child (fry, larvae, pup, chick etc.) and its future children. Thousands of chemicals have been found to be endocrine disruptors. Some of them are very resistant to degradation and remain in the environment and in peoples bodies for decades or longer. Many of these are no longer in use even though we can still easily detect them. They were found to be a threat to health and were banned and/or replaced with something less dangerous. There are many other chemicals in use that have not been tested. There are others that are current foci of research and debate. These chemicals were not developed to cause harm to humans (at least not most of them), rather they were found to be harmful after they were already in use. An example that you may be aware of is the plastics ...
Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) and Seveso Womens Health Studies (SWHS) similarities: 1. Both are prospective cohort studies of more highly exposed populations; 2. Both use biomarkers of exposure; and, 3. Both study multiple health outcomes. CHAMACOS and SWHS differences: 1. CHAMACOS focuses on childrens health, SWHS focuses on womens health. 2. CH
Ask your health care provider any questions you may have about how to use Levitra Plus.. STORAGE. Store Levitra Plus at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Levitra Plus out of the reach of children.. MORE INFO:. Active Ingredient: Vardenafil 10mg.. Other Ingredients:. Ginseng stimulates and increases endocrine activity in the body. It increases metabolic activity and relaxes heart and artery movements. Ginseng also stimulates the medulla centers and relaxes the central nervous system. Ginseng also increases more successfully erections, sexual desire and intercourse in comparison with placebo.. L-Arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-Arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation). Together with reduction of blood vessel stiffness L-Arginine ...
Ask your health care provider any questions you may have about how to use Levitra Plus.. STORAGE. Store Levitra Plus at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Levitra Plus out of the reach of children.. MORE INFO:. Active Ingredient: Vardenafil 10mg.. Other Ingredients:. Ginseng stimulates and increases endocrine activity in the body. It increases metabolic activity and relaxes heart and artery movements. Ginseng also stimulates the medulla centers and relaxes the central nervous system. Ginseng also increases more successfully erections, sexual desire and intercourse in comparison with placebo.. L-Arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-Arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation). Together with reduction of blood vessel stiffness L-Arginine ...