Concern that selected chemicals in the environment may act as endocrine active compounds in aquatic ecosystems is widespread; however, few studies have examined the occurrence of endocrine active compounds and identified biological markers of endocrine disruption such as intersex occurrence in fish longitudinally in a river system. This report presents environmental data collected and analyzed by the U.S. Geological Survey, Minnesota Pollution Control Agency and St. Cloud State University as part of an integrated biological and chemical study of endocrine disruption in fish in the Mississippi River. Data were collected from water, bed sediment, and fish at 43 sites along the river from the headwaters at Lake Itasca to 14 miles downstream from Brownsville, Minnesota during June through August 2006. Twenty-four individual compounds were detected in water samples, with cholesterol, atrazine, N,N-diethyl-meta-toluamide, metolachlor, and hexahydrohexamethylcyclopentabenzopyran detected most ...
In 2000, the U.S. Environmental Protection Agency (EPA) nominated four types of in vitro test methods for ICCVAM to review. These test methods were proposed for use in the EPA Endocrine Disruptor Screening Program.. NICEATM gathered relevant data and prepared a review document of the four types of tests. An independent expert panel review concluded that there were no adequately validated in vitro endocrine disruptor screening tests.. ICCVAM considered the panels conclusions and recommendations, along with comments from the public, as it developed its final test method evaluation report.. ...
EFSA is currently involved in a number of initiatives to develop scientific knowledge in the field of endocrine active substances and also on overlapping issues such as non-monotonic dose-response relationships and biological relevance in risk assessment. This work follows up on a 2013 scientific opinion by EFSA which provided a definition of endocrine disruptors.
The evaluation of endocrine active substances is currently under discussion. EU legislation demands extensive consequences for endocrine disruptors: biocides and pesticides containing endocrine disruptive substances may not be placed on the market. Endocrine active substances may be placed on the candidate list for authorisation on a case-by-case basis in the context of REACH. Currently, no standardised definition or evaluation criteria for endocrine disruptors exist in the EU. The previous goal to elaborate such criteria untill the end of 2013 has been postponed till October 2014. Endocrine disruptors and regulatory consequences are the topic of the next Advanced Course in Toxicology of the Working Group Regulatory Toxicology of the German Society of Toxicology (DGPT). This course takes place on 31 March 2014 as satellite activity of the annual conference of the DGPT in Hannover. FoBiG is presenting results of an actual project. You find the program and the registration form for the course ...
Objectives We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case-control study from nine European countries.. Methods After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure.. Results The overall exposure prevalence to EDC was low reaching a maximum of 11% for ...
Endocrine-disrupting chemicals (EDCs)-such as BPA-can show tangible effects on health endpoints at high dosage levels, yet those effects do not predict how EDCs will affect the endocrine system at low doses, according to a recent study accepted for publication in The Endocrine Societys Endocrine Reviews.
Department of Public Health - Institute of Environmental and Occupational Medicine, Department of Public Health, Health, Aarhus ...
The development of the male reproductive system requires the action of different hormones and is highly susceptible for development to be altered due to endocrine disruptions. Cryptorchidism is the failure of descent of the testis and is the most common congenital malformation in males. Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are some of the most widely used drugs used. These drugs have recently been identified as potential endocrine disruptors (ED) in humans. A number of epidemiological studies have reported that exposure to NSAIDs and analgesics during pregnancy showed an increased risk of cryptorchidism. This study used 62 fetuses from the first trimester between 7-12 weeks in gestation (GW) from pregnant women who obtained an abortion legally and with were given information and verbal consent was obtained according to national guidelines. The terminations were not motivated by abnormalities. The testes were cut in approximately 1mm3 pieces and drugs were used in the ...
The development of the male reproductive system requires the action of different hormones and is highly susceptible for development to be altered due to endocrine disruptions. Cryptorchidism is the failure of descent of the testis and is the most common congenital malformation in males. Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are some of the most widely used drugs used. These drugs have recently been identified as potential endocrine disruptors (ED) in humans. A number of epidemiological studies have reported that exposure to NSAIDs and analgesics during pregnancy showed an increased risk of cryptorchidism. This study used 62 fetuses from the first trimester between 7-12 weeks in gestation (GW) from pregnant women who obtained an abortion legally and with were given information and verbal consent was obtained according to national guidelines. The terminations were not motivated by abnormalities. The testes were cut in approximately 1mm3 pieces and drugs were used in the ...
Even at very low doses, endocrine-disrupting chemicals (EDCs) that mimic the action of naturally occurring estrogens impair the bodys secretion of glucagon, according to a study.
Youre likely exposing yourself to endocrine-disrupting chemicals if you are eating packaged food, washing your clothes with regular detergent, and more.
This Test Guideline describes the Medaka Extended One Generation Test (MEOGRT), which exposes fish over multiple generations to give data relevant to ecological hazard and risk assessment of chemicals, including suspected endocrine disrupting chemicals (EDCs). Exposure in the MEOGRT starts with spawning fish (P or F0 generation) and continues until hatching (until two weeks post fertilization, wpf) in the second (F2) generation. This Test Guideline measures several biological endpoints. Primary emphasis is given to potential adverse effects on population relevant parameters including survival, gross development, growth and reproduction (fecundity). Secondarily, in order to provide mechanistic information and provide linkage between results from other kinds of field and laboratory studies, where there is a posteriori evidence for a chemical having potential endocrine disrupter activity (e.g. androgenic or oestrogenic activity in other tests and assays) then other useful
The U.S. Environmental Protection Agency (EPA), after much delay, has released a list of potential endocrine disruptors. Included are 73 chemicals, 69 of which are pesticides and 4 are inert and used in pesticides. The effects include endocrine effects, anti-androgenic activity or anti-estrogenic activity. There is concern amongst a number of scientists that many chemicals […]. View Post ...
EDSP FAQs. Overview:. Substances that mimic, influence, or interfere with the bodys endocrine system at certain doses, and produce potentially adverse developmental, reproductive, neurological, and/or immune effects in both humans and wildlife, are called endocrine disruptors. These substances can be naturally-occurring or man-made. Endocrine issues have long been the subject of intense regulatory interest and scientific debate. In the last decade, substances that may have endocrine effects have been subject to increased regulatory attention, and companies making or using these substances must stay keenly abreast of the sometimes murky and controversial legal and scientific developments regarding endocrine disruptors.. The Food Quality Protection Act (FQPA), Federal Food, Drug, and Cosmetic Act (FFDCA), and Safe Drinking Water Act (SDWA) each requires the U.S. Environmental Protection Agency (EPA) to screen pesticides, commercial chemicals, and environmental contaminants to determine whether ...
BKH/European Commission. Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption: - preparation of a candidate list of substances as a basis for priority setting. Final report-November 2000. http://europa.eu.int/comm/environment/docum/01262_en.htm#bkh. Category 1 chemicals from Annex 1: Candidate list of 553 substances. http://europa.eu.int/comm/environment/docum/bkh_annex_01.pdf, Brucker-Davis, F. Effects of Environmental Synthetic Chemicals on Thyroid Function. Thyroid. 8(9): 827-856. 1998., Illinois EPA. Endocrine Disruptors Strategy. 1997. (Table 1: Preliminary List of Chemicals Associated with Endocrine System Effects in Animals and Humans or In Vitro). http://www.nihs.go.jp/hse/environ/illiepatable.htm, Japanese National Institute of Health Sciences. Lists of Paradigmatic Chemicals. http://www.nihs.go.jp/hse/endocrine-e/paradigm/paradigm.html, Keith, L.H. (ed.). Environmental Endocrine Disruptors. John Wiley & Sons, NY. 1997. ...
Endocrine disruptors are exogenous substances that alter the functions of the endocrine system and consequently cause adverse health effects in an intact system, its progeny and the larger population. During the last century, many endocrine disrupting compounds have been synthesised and released into the environment. The production of several of these compounds has been phased out, because of either legislation or voluntary action by the companies that manufacture the compounds. In many cases, this has led to a reduction of exposure in humans and the environment. However, negative health effects might still be present at these lower levels. For several groups of endocrine disruptors, there have been substitutions of one compound for other compounds with similar chemical structure. The toxicity of the newly introduced compounds is often less known than the effect of the one originally used, which can lead to adverse health effects with eventual restrictions of the new compounds. We discuss here ...
Introduction During the last decade, numerous studies have been published, reporting an increase in male reproductive organ anomalies, as well as in testicular cancer, and a decline in the relative number of male births, and in semen quality. At the same time, a growing number of therapeutical as well as environmental chemicals with recognized estrogenic, anti-androgenic or other hormonal activity have been focused on, as being potentially responsible for the mentioned anomalies. Many studies have been carried out, on experimental animals, as well as through observation of exposed human cohorts, in an attempt to gather evidence on the suspected developmental toxicity of these substances, in general referred to as endocrine disruptors. Observed anomalies and trends Sex ratio Sex ratio is measured as the ratio of male to female births, and its normal value, with slight deviations, is considered to be of 1.06, that is 106 males for every 100 females born (Davis et al., 1998). Numerous factors have ...
Scientists today reported widespread global contamination of sea sand and sea water with the endocrine disruptor bisphenol A (BPA) and said that the BPA probably originated from a surprising source: Hard plastic trash discarded in the oceans and the epoxy plastic paint used to seal the hulls of ships.
That these public policies further should be based on data that comprehensively include both low-level and high-level exposures.. Currently, there is no comprehensive, coordinated approach to regulating EDCs in the U.S. In 1996, Endocrine Disruptors (EDCs) were formally recognized as a public health concern when Congress passed the Food Quality Protection Act (FQPA) and amendments to the Safe Drinking Water Act. Years behind a statutory schedule, in 2009 the U.S. Environmental Protection Agency (EPA) issued its first test orders for screening of dozens of high-priority pesticides for endocrine disrupting effects. The agency subsequently announced that it has expanded its testing and identified a list of chemicals that will be screened for their potential to disrupt the endocrine system, along with a draft of the policies and procedures that the agency has proposed to follow for testing. However, the agency has yet to finalize its procedures or officially test a chemical for endocrine disruption ...
Endocrine disruptors pose a substantial risk to public health, yet the European Commission has dawdled time and again on introducing measures that would finally limit their use. Now is the time to put this right, write Genon Jensen and Michael Warhurst.. Genon Jensen is the Executive Director of the Health and Environment Alliance (HEAL) and Michael Warhurst is the Executive Director of CHEM Trust.. Over twenty years ago, scientists began to be concerned about chemicals that could disrupt our bodys sensitive hormone (or endocrine) system, which are particularly crucial in development and reproduction, also known as endocrine disrupting chemicals (EDCs). In spite of the fact that chemicals with these properties are found in everyday products, the EU still has not agreed the criteria to identify such EDC chemicals.. Without such criteria the people of Europe - and our environment - are not being properly protected and concerns continue to mount in medical and cancer communities and among leading ...
BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.. ...
Research. The focus of my basic science research program is to determine the effects of endocrine disruptors on reproductive cells. Specifically, I study ovarian follicular maturation in the adult and germ cell migration during early embryonic development; both lines of experimentation utilize zebrafish (a vertebrate model heavily used in developmental biology and genetics). Endocrine disruptors (EDs) are prominent in the environment as herbicides, pesticides, plasticizers and numerous other agents. These compounds have been shown to negatively impact both wildlife and human populations, often through binding to steroid receptors. Because of their potential to bind steroid receptors these compounds are particularly disruptive to the tightly controlled mechanisms of neural and reproductive development as well as adult neural, thyroid and reproductive function.. As human females approach menopause there is an increasing chance of conceiving children with chromosomal anomalies such as too many ...
About the Book. This Endocrine Disruptors, Brain and Behavior is edited by Heather B. Patisaul and Scott H. Belcher. This First Edition textbook focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence.. Features. - The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps ...
We all desire health and vitality; theyre the reasons many people commit to a more natural way of living. While you may try to be careful about what you put in your body, have you thought about what youre putting on your body? Our skin absorbs much of what we put on it, so much so that doctors often prescribe medicine to be topically administered.. Did you know that many of the conventional beauty and personal care products we apply to our skin are laden with potentially harmful chemicals that are known to alter your bodys natural cycles and processes?. One of the most threatening of these substances are endocrine disruptors or hormone disruptors. These interfering chemicals are shockingly common and have been associated with numerous health issues, from increased cancer risk to infertility.. Hormone disruptors affect your bodys endocrine system in several ways. Many of these chemicals imitate the natural hormones in your body by decreasing or increasing their production and interfering with ...
Earlier this year, a landmark paper appeared titled Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses, published in Endocrine Reviews, a journal of the prestigious Endocrine Society. In this 78-page review, supported by 845 references, twelve leading environmental health researchers challenge the dogma of "the dose makes the poison," noting that endocrine-disrupting chemicals (EDCs) can have effects at low doses that are not predicted by effects at higher doses, and noting that fundamental changes in chemical testing and safety determination are needed to protect human health. The paper has received much attention. On this call, three of the authors of this paper will summarize their work and responses to it. ...
Dear Reader,. We know that dangerous chemicals like hormone disruptors are found in many products.. Thats why EWG has partnered with the Keep A Breast Foundation to develop our latest report - the Dirty Dozen list of endocrine disruptors.. There is no end to the tricks that endocrine disruptors can play on our bodies: increasing production of certain hormones; decreasing production of others; imitating hormones; turning one hormone into another - and so much more.. Click here to see this list of the dirtiest and most common endocrine disruptors.. The EWG/KAB Dirty Dozen list includes BPA, phthalates and other endocrine disruptors that are widespread in consumer products such as plastic containers, food cans and fragrances. The list also includes common contaminants that many people dont realize can be hormone disruptors, not only those familiar toxins - arsenic, mercury and lead - but other, less familiar chemicals such as glycol ethers and perfluorinated chemicals. The guide is intended for ...
Skinner MK. Growth factor regulation and phenotype sexual differentiation in the female and male fetus. Impact of endocrine disruptors. Presented at the National Institute of Environmental Health Sciences, U.S. Environmental Protection Agency, National Institute of Child Health and Human Development Gender Differences by Reproductive Biology and Toxicology Symposium, Tucson, AZ, November 2000 ...
Abstract: The toxic effect of various environmental contaminants such as heavy metals or industrial chemicals such as alkylphenolson male reproductive systemwasfound. 4-nonylphenol (4-NP), one of the environmental contaminants used in the manufacture of plastics and other products, is released largely into the environment. The majority of studies on NP have focused on their endocrine disrupting and potential adverse effects on reproductive system. The target of our in vitro study was to determine the potential impact of 4-nonylphenol as an endocrine disruptor on the hormonal secretion and viability of mice Leydig cells. Cells were cultured with addition of 0.04; 0.2; 1.0; 2.5; and 5.0 µg/mL of 4-nonylphenol for 44h and compared with the control. Cells destined for the determination of androstenedione production were cultured in the presence of cyclic AMP solution. Quantification of cAMP stimulated androstenedion production directly from aliquots of the medium was performed by enzyme linked ...
The present study examined the influence of endocrine active compounds (endocrine disruptors, ED), which are present in surface waters, on reproductive biology of aquatic organisms. The amphibian Xenopus laevis is a well-established model organism for the study of effects of ED on reproduction. It has been modified and broadened for the purpose of this study, and it was combined with chemical methods for water analyses. It is possible to assess water pollution with ED by detecting effects on repro-ductive biology of one particular substance, and then by looking for this substance in environmental water samples. We showed the feminizing potency of Bisphenol A (BPA) in conducting exposure experiments with tadpoles, in examining histological samples of gonads and in detecting the induction of the expression of a molecular estrogenic biomarker. BPA was recognized to mediate its effects via binding to the estrogen receptor. Moreover, analysis of BPA during exposure experiments revealed that BPA is ...
Bisphenol A is back in the headlines this week after a new report found high levels of the endocrine disruptor on 40 percent of receipts from businesses. Lab results from a study commissioned by the Environmental Working Group found thermal paper used by a number of major U.S.
Bisphenol A is back in the headlines this week after a new report found high levels of the endocrine disruptor on 40 percent of receipts from businesses. Lab results from a study commissioned by the Environmental Working Group found thermal paper used by a number of major U.S.
Managing Editors Note: I apologize we missed this post earlier in the week from SafeMinds board member Deirdre Imus on HuffPo. Could Endocrine-Disrupting Chemicals in Vaccines Cause Autism? ...Environmental triggers, including endocrine-disrupting chemicals (EDCs), is an area in which autism...
Study Objectives Characterize the extent of EDC contamination in the Assabet River Characterize EDCs and other CECs* in the effluents from the four major WWTPs on the river Evaluate the impacts of EDCs on fish (minnows) reproductive health (feminization of males) in the river Provide data that informs NPDES permit decisions regarding the need for reductions of inputs of EDCs * CECs = Contaminants of Emerging Concern 3
Abstract: The last 40 years have seen many reports that man-made chemicals and environmental pollutants cause adverse effects in humans and wildlife; however, actually linking an exposure with a mechanism and an effect has yet to be done for endocrine disruption. Certainly, studies in experimental animals have shown that sufficient doses of select compounds can disrupt the endocrine system and produce the attendant adverse outcomes. The purpose of this contribution is to evaluate some of the recent reports of the adverse effects on reproduction and development, the immune system, and the nervous system that have been observed in experimental animals after treatment with man-made chemicals and environmental pollutants. Space limitations prevent us from presenting a comprehensive review of all reported endocrine active chemicals and their effects. Instead, we have focused on drawing conclusions as to the scope and etiology of the adverse effects in experimental animals using examples from the ...
A growing number of anthropogenic xenobiotic pollutants regularly affect the aquatic environment. Some of these compounds are suspected or known to have effects on the endocrine system of marine organisms. These molecules are known as endocrine disruptors and have multiple modes of action: binding to hormonal receptors, modifying intrinsic concentrations of natural hormones acting on their production, their storage, transport, metabolism and excretion. Whatever their mode of action, their effects are deleterious to fish: dysfunctional thyroid function, behavioural disturbance, incomplete development of genitalia, decreased fertility, development of imposex ... the presence of endocrine disruptors in the environment, even in trace amounts, has a direct impact on the health of marine organisms (e.g. feminization of certain fish populations and vice versa) and, ultimately, perhaps on man. In order to complement existing knowledge on the modes of action and effects of endocrine disruptors, this ...
Bisphenol S (BPS) is an endocrine-disrupting chemical with multiple potential mechanisms of action, including as an oestrogen receptor agonist. BPS is increasingly used in plastics and thermal receipts as a substitute for bisphenol A, which has been phased out due to concerns about human health implications. The ability of BPS to alter female reproductive function in mammals has not been widely studied, despite the importance of normal hormone signalling for female reproduction. The aim of this study was to investigate how BPS (in a wide range of doses, including very low doses) affects granulosa cell and theca cell steroid hormone production and cell viability in the bovine ...
In their new study, experts at the University of Michigan School of Public Health say that triclosan and bisphenol A are both part of a class of chemicals known as endocrine-disrupting compounds (EDC).. These substances act in the human body by mimicking the action of hormones, or by inhibiting and boosting the action of hormones beyond normal activity levels, leading to imbalances with negative implications for health.. "We found that people over age 18 with higher levels of BPA exposure had higher CMV [cytomegalovirus] antibody levels, which suggests their cell-mediated immune system may not be functioning properly," explains Erin Rees Clayton.. The scientist holds an appointment as a research investigator at the U-M School of Public Health, and was also the first author of a new paper detailing the findings, which appears in the November 30 online issue of the journal Environmental Health Perspectives.. The team used data collected from the 2003-2006 National Health and Nutrition Examination ...
All the chemicals listed above are endocrine disruptors, meaning that they interfere with the workings of the endocrine -- or hormone -- system. Hormones are our bodies chemical messengers. They tell cells to start or stop carrying out key functions at the proper time. While key to basic body functioning throughout our lives, they are particularly important to fetal development. During the nine months in which a baby takes shape, an exquisitely timed orchestra of these chemical signals ensures that the babys body develops as it should. Any tampering with the type or timing of the signals can have tragic consequences, from cancers that emerge later in life to missing body parts. They can also affect the brain and behavior. The years directly leading up to puberty, when hormones again play a major role in body development, may be another time when people are particularly sensitive to endocrine-disrupting chemicals. ...
All the chemicals listed above are endocrine disruptors, meaning that they interfere with the workings of the endocrine -- or hormone -- system. Hormones are our bodies chemical messengers. They tell cells to start or stop carrying out key functions at the proper time. While key to basic body functioning throughout our lives, they are particularly important to fetal development. During the nine months in which a baby takes shape, an exquisitely timed orchestra of these chemical signals ensures that the babys body develops as it should. Any tampering with the type or timing of the signals can have tragic consequences, from cancers that emerge later in life to missing body parts. They can also affect the brain and behavior. The years directly leading up to puberty, when hormones again play a major role in body development, may be another time when people are particularly sensitive to endocrine-disrupting chemicals. ...
This study sought to construct a transcriptomics-based framework of signal transduction pathways, transcriptional regulatory networks, and the hypothalamic-pituitary gonadal (HPG) axis in zebrafish (Danio rerio) to facilitate formulation of specific, testable hypotheses regarding the mechanisms of endocrine disruption in fish.
Up to 800 chemicals in everyday products may be endocrine disrupting. Learn more about the risk to health from endocrine disrupting chemicals (EDCs).
Exposure of the developing embryo to endocrine disrupting chemicals (EDCs) has been proposed to underlie a number of human health problems, including birth defe...
My Notes From The Healthy Gut Summit Dr. Sara Gottfried The liver is key to hormone health and easily overwhelmed especially by endocrine disruptors and environmental toxins. Endocrine disruptors are zenoestrogens we get exposed to that are plastics and pesticides. They disrupt your endocrine system and the endocrine receptors, also your gut microbiome and your…
BPA?... Phthalates... You know they can be dangerous for your family, but you may not know all the ways they enter your body, or -- most important -- how you can limit your exposure. Parents magazine investigates.
The next time youre at the grocery, pick up a conventionally grown apple and an organically grown apple. Smell them. While the organic apple will be more fragrant, there wont be much difference in the way they look.. But what you cant see can hurt you.. Pesticides - in "conventionally grown" fruits and veggies - are powerful endocrine disruptors. They affect your delicate hormonal system - which, in turn, affects everything from your weight and mood to your risk of cancer and infertility. And most Americans eat over a gallon of these health-harming chemicals each year.. Pesticides (and other endocrine disruptors) are measured in nanometers (nM). Professor Michael Mackay helps put the miniscule size of these compounds into perspective by using a Post-It note.. Hold a 3 x 3 inch Post-It note out in front of you - at arms length. Now imagine how small that Post-It would look if it were halfway around the world from the spot where you are standing. Pretty small, huh? That is 3 nM - the size of ...
Challenging risk assessment methods used for decades by toxicologists, a new review of the literature led by environmental health scientist Laura
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process ...
A provocative new study published in the journal Hormone Research in Paediatrics confirms for the first time in a human trial that one of the adverse
Endocrine-disrupting chemicals are responsible for hundreds of thousands of cases of fibroids and endometriosis in the European Union, at an annual cost of billions of Euros, say US researchers.
The sex steroids found naturally in animal products likely exceed the hormonal impacts of endocrine-disrupting chemical pollutants.
Teens are a vulnerable subpopulation when it comes to thyroid disruption from environmental chemicals, which can affect cognitive function, bone strength and metabolism, growth rates, and academic performance.
EPA implements screening, testing and research programs to gather information the Agency uses to evaluate possible endocrine effects associated with the use of a chemical. EPA takes appropriate steps to mitigate any related risks to ensure protection of public health and the environment. ...
Albanis T., Allera A., Bachmann J., Barbaglio A., Berntsson P., Dittmann N., Candia D., Carnevali D.C., Ciceri F., Dagnac T., Duft M., Falandysz J., Galassi S., Hala D., Gemma Janer, Roger Jeannot, Susan Jobling, Isabella King, Dietrich Klingmüller, Werner Kloas, Kresten Ole Kusk, Ramon Lavado, Susan Lo, Ilka Lutz; Jörg Oehlmann, Stina Oredsson, Cinta Porte, Marian Rand-Weaver, Vasilis Sakkas, Claudia Schmitt, Ulrike Schulte-Oehlmann, Michela Sugni, Charles Tyler, Ronny van Aerle, Van Ballegoy C., Wollenberger L.: Comparative Research on Endocrine Disrupters - Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds. COMPRENDO. EU Contract No. EVK1-CT-2002-00129.FINAL PUBLISHABLE REPORT Executive Summary On The Project Results. March 2006. Imprint: EU - Energy, Environment and Sustainable Development, 2006 Status: Published ...
1] Regulation of Energy Metabolism Pathways by Estrogens and Estrogenic Chemicals and Potential Implications in Obesity Associated with Increased Exposure to Endocrine Disruptors. URL < www.ncbi.nlm.nih.gov/pmc/articles/PMC2747085/?tool=pmcentrez >.. ...
Even in the water we now face agents who threaten to become fat. Some environmental chemicals are endocrine disruptors that alter the metabolism and end up influencing, albeit at a…. ...
Pharmacokinetic behavior of environmental chemicals, mechanisms of action of toxicants including endocrine disruptors, and linking of real-world exposures to health effects ...
Affiliation:岐阜大学,農学部,教授, Research Field:基礎獣医学, Keywords:ステロイド合成,精子形成,内分泌かく乱物質,精原細胞,Steroidogenesis,Wild animal,静子形成,Environmental Hormone,生殖異常,Endocrine disruptor, # of Research Projects:2, # of Research Products:0
Causes and Prevention of Breast Cancer. Feb. 2005: Special Sale Offer! Despite the fact that the cancer epidemic has not ended, my publisher has decided to take this book out of print. Far too few people understand that cancer is caused by...carcinogens! These are the chemicals, pesticides, endocrine disrupters, and nuclear radiation that are contaminating our environment. We need to educate our friends and colleagues in order to stop this epidemic.. Lesen Sie mehr unter: www.janettesherman.com. Dort finden Sie auch weitergehende Links. ...
TY - JOUR. T1 - Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. AU - Vrijheid, M. AU - Armstrong, B. AU - Dolk, Helen. AU - van Tongeren, M. AU - Botting, B. PY - 2003. Y1 - 2003. U2 - 10.1136/oem.60.8.543. DO - 10.1136/oem.60.8.543. M3 - Article. VL - 60. SP - 543. EP - 550. JO - Occupational and Environmental Medicine. JF - Occupational and Environmental Medicine. SN - 1351-0711. IS - 8. ER - ...
Single Center, Therapeutic Exploratory Clinical Trial to Evaluate the Safety of Sodium Oxybate (Xyrem) 500 mg/mL Oral Solution on Potential Endocrine Changes at Currently Labeled Therapeutic Dose Regimens (4.5 - 9 g/Day Divided Into Two Equal Doses) During 12 Weeks of Treatment of Cataplexy in Adult Patients With Narcolepsy ...
At 4:47 pm we are told the observed endocrine disruptor activity from CHDM reactions should be asrcibed to generic and unspecified reaction products of any substance that can be hazardous.. At 9:58 pm we are told from the same source that observed endocrine disruptor activity is due to a very specific esterification process with a specific reagent.. At 3:03 AM I specifically addressed the prospect that observed endocrine disruptor activity from HPAA among the reaction products must specifically excluded. Oddly enough, that mechanism didnt seem to merit at 4:47 PM, but assumed central importance five hours later. This continually moving causal explanation is highly consistent with the goal of denying possible toxicity - and intellectually incoherent.. The data set has not changed in those five hours: the rationale for dismissal of potential endocrine disruptor activity has jumped around a fair bit. Qui bono?. The cited report clearly indicates that HPAA was independently assayed for ED ...
This story, published on 5 September, has been updated to make clear the Commissions draft criteria referred to biocidal products. Below is the updated story.. EU national representatives adopted on Monday (4 September) the European Commissions draft criteria for endocrine disruptors in biocidal products, laying the foundation for a comprehensive strategy to limit citizens exposure to harmful substances.. The EU voted to ban endocrine disruptors in 2009. But so far the ban has not come into effect due to a lack of criteria defining the chemicals that it should cover.. Endocrine disruptors are chemical substances that are suspected of triggering diseases such as cancer or diabetes and contributing to people becoming overweight or infertile through changes to the endocrine (or hormone) system.. They are commonly found in everyday plastic products, food packaging and agricultural chemicals and can be absorbed by the body in a number of ways.. Mondays vote was the first step in the EUs adoption ...
NutritionFacts.org, by Michael Greger: In 1979, an epidemic of breast enlargement was noted in Italian children. Poultry or veal was suspected, given that estrogens "may be fed to farm animals to accelerate their weight gain." "After this episode, the European Union banned the application/use of anabolic growth promoters in agriculture," as well as the importation of American meat from animals injected with drugs like Zeranol, sold as "Ralgro Magnum.". Zeranol, one of the most potent known endocrine disrupters, is 100,000 times more estrogenic than the plastics chemical, BPA, for example, and is the subject of my video Zeranol Use in Meat and Breast Cancer. "Zeranol constitutes a special case among potential endocrine disrupters, because Zeranol, in contrast to all other oestrogenic endocrine disrupting chemicals, is present in human food because it is deliberately used in the production of consumer products. Furthermore, Zeranol is designed to be a potent, fairly persistent [estrogen] whereas ...
The main objective of this research project is to understand how in utero Bisphenol A (BPA) exposure affects fetal gonadal development and reproduction in adulthood in mice. In utero exposure to estrogenic endocrine disruptors such as diethylsfilbestrol (DES) is known to cause sex organ malformation, reproductive carcinogenesis, and fertility defects in both male and female in humans and rodents. Based on DES studies, it is proposed that in utero exposure to other endocrine disruptors, particularly those that work through estrogen receptors, may lead to reproductive diseases in adulthood. BPA, a chemical used in synthesis of plastics, exhibits estrogenic activities and deleterious effects on reproduction when given to adult rodents. BPA is detected in serum of pregnant women, umbilical cord blood, and fetal plasma, indicating that developing fetuses are exposed to BPA. Although effects of BPA on adult reproductive organs have been studied extensively, impacts of in utero BPA exposure ...
Increased exposure of birds to endocrine disrupting compounds has resulted in developmental and reproductive dysfunctions. We have recently identified the flame retardants, ally1-2,4,6-tribromophenyl ether (TBP-AE), 2-3-dibromopropy1-2,4,6-tribromophenyl ether (TBP-DBPE) and the TBP-DBPE metabolite 2-bromoallyI-2,4,6-tribromophenyl ether (TBP-BAE) as antagonists to both the human androgen receptor (AR) and the zebrafish AR. In the present study, we aimed at determining whether these compounds also interact with the chicken AR. In silico modeling studies showed that TBP-AE, TBP-BAE and TBP-DBPE were able to dock into to the chicken AR ligand-binding pocket. In vitro transfection assays revealed that all three brominated compounds acted as chicken AR antagonists, inhibiting testosterone induced AR activation. In addition, qRT-PCR studies confirmed that they act as AR antagonists and demonstrated that they also alter gene expression patterns of apoptotic, anti-apoptotic, drug metabolizing and amino ...
Endocrine disrupting chemicals (EDC) are compounds that alter the normal functioning of the endocrine system of both wildlife and humans. A huge number of chemicals have been identified as endocrine disruptors, among them several pesticides. Pesticides are used to kill unwanted organisms in crops, public areas, homes and gardens, and parasites in medicine. Human are exposed to pesticides due to their occupations or through dietary and environmental exposure (water, soil, air). For several years, there have been enquiries about the impact of environmental factors on the occurrence of human pathologies. This paper reviews the current knowledge of the potential impacts of endocrine disruptor pesticides on human health.
Learn about the role endocrine-disrupting chemicals (EDCs) may have on the metabolism and how they may be contributing to the obesity epidemic from the Endocrine Society.
Pesticide formulations contain declared active ingredients and co-formulants presented as inert and confidential compounds. We tested the endocrine disruption of co-formulants in six glyphosate-based herbicides (GBH), the most used pesticides worldwide. All co-formulants and formulations were comparably cytotoxic well below the agricultural dilution of 1% (18-2000 times for co-formulants, 8-141 times for formulations), and not the declared active ingredient glyphosate (G) alone. The endocrine-disrupting effects of all these compounds were measured on aromatase activity, a key enzyme in the balance of sex hormones, below the toxicity threshold. Aromatase activity was decreased both by the co-formulants alone (polyethoxylated tallow amine-POEA and alkyl polyglucoside-APG) and by the formulations, from concentrations 800 times lower than the agricultural dilutions; while G exerted an effect only at 1/3 of the agricultural dilution. It was demonstrated for the first time that endocrine disruption by GBH
① Water tanks breeding Medaka ② Medaka pair ( ♂ 1 - ♀ 1or2 ) ③ Collect fertilized eggs every morning. ⑥ Observe the embryos under stereo-microscope. ④ Incubate the eggs in an incubato r for 24 hours at 26±0.5 ℃. On the next day, remove dead eggs. Method of egg collection and observation ⑤ Settle the eggs into each well of a microtiter plate wit h 200 m l of dioxin solution. ⑦ RNA extraction ⑧ Quantitative RT- PCR
Belfast Free Library, 106 High St. Endocrine Disruptors in Aquatic Ecosystems: What can hormones tell us about the health of Maines aquatic environment? Dr. Heather Hamlin, UMaine Department of Marine Biology and Aquaculture, investigates how human-induced changes affect the reproduction and development of aquatic animals, and solutions to promote resilience of Maines aquatic resources.. ...
Green Guidance Hormone-Altering Chemicals in Everyday Products Androgyny on the fashion runway is one thing, but in the Arctic no one wants to see gender-confused polar bears. Yet according to scientists, one in 67 female polar bears in Svalbard, Norway, has developed a stunted penis. The suspected cause is exposure to endocrine-disrupting chemicals, particularly polychlorinated biphenyls (PCBs). Elsewhere, the chemicals have been linked to female mollusks growing penises, fish bearing both sex organs, and reproductive difficulties among mammals. In humans, breast milk contaminated with phthalate plasticizers has been shown to alter hormone levels in three-month-old boys, resulting in incomplete virilization. With 966 known or suspected endocrine-disrupting chemicals in existence-and often in the environment-elimination is unlikely. The European Unions new REACH legislation, which requires that manufacturers find substitutes for the most dangerous of the chemicals in consumer products, will ...
June 26, 2012 /Press Release/ -- A lifestyle that features fresh foods and limited use of products likely to contain environmental chemicals has been shown to reduce exposure to endocrine-disrupting chemicals (EDCs)C such as BPA and phthalates, in a small population study. EDCs are linked to a number of adverse health complications including neuro-developmental delays, behavioral issues and fertility problems. They are produced by the millions of pounds per year and found extensively in a range of products that contain certain plastics.. Researchers from Mount Sinai School of Medicine and University of Rochester School of Medicine and Dentistry examined individual behavioral choices and community lifestyle practices, as well as analyzed urine samples, from a group of Old Order Mennonite (OOM) women in mid-pregnancy and determined that they have lower levels EDCs in their systems than the general population. The study is published online today in the journal NeuroToxicology.. Bisphenol A (BPA) ...
Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction (Dietert et al. 2010). Mounting epidemiological evidence suggests that proper function of the immune system is a major determinant of health across the life course (Dietert et al. 2010). For example, those with childhood asthma may have an elevated risk of developing lung cancer (Dietert et al. 2010), and among individuals ≥ 87 years old, immune dysregulation has been linked with dementia (Katsel et al. 2009). Exposure to environmental toxicants, therefore, may cause life-long changes in response to infectious agents, in immune homeostasis, and in overall physical and mental health (Dietert et al. 2010).. One group of environmental toxicants affecting immune system function is endocrine-disrupting compounds (EDCs) (Chalubinski and Kowalski 2006). In 1996, the U.S. Congress first recognized EDCs as a public health concern when it mandated that ...
Human nuclear receptors control the expression of genes in response to the binding of small signalling molecules in the body. Many compounds that are in the environment are classed as endocrine-disrupting chemicals as they are thought to directly bind nuclear receptors and change gene expression patterns, leading to harmful physical effects. While many of these compounds are harmless individually, the body is constantly exposed to mixtures of these compounds in the environment. It has long been known that combinations of these chemicals can have additive, antagonistic or synergistic effects, but there has been no understanding of the molecular basis for these effects.. The teams of Patrick Balaguer and William Bourguet of INSERM, CNRS and the University of Montpellier used extensive screening methods and biophysical characterisation to identify two endocrine-disrupting chemicals that act synergistically on a human nuclear receptor, the pregnane X receptor (PXR). The two compounds identified are ...
Advances in Epidemiology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of epidemiology.
Endocrine disruptors are chemicals that can obstruct with endocrine systems at certain doses. These disruptions can cause tumoroustumors, birth defects, and other developmental disorders. Any system in the body well-ordered by hormones can be derailed by hormone disruptors. Specifically, endocrine disruptors may be associated with the development of learning disabilities, severe attention deficit disorder, perceptive and brain development problems deformations of the body that includes breast cancer, prostate cancer, thyroid and other cancers; sexual development problems for example feminizing of males or masculinizing effects on females, etc.. ...
It is prudent to avoid the use of dietary supplements of L-glutamic acid by pregnant women, infants, and children. The existence of evidence of potential endocrine responses, i.e., elevated cortisol and prolactin, and differential responses between males and females, would also suggest a neuroendocrine link and that supplemental L-glutamic acid should be avoided by women…. ...
7/7/2015; Freshwater ecosystems play a central role in the environment. Through various processes such as nutrient recycling, groundwater recharging, and the attenuation of many pollutants these biological systems help to maintain environmental health. Unfortunately, many recent studies have identified emerging threats to these special environments and the life they sustain. One source of mounting concern is a group of compounds that interact with the endocrine systems of humans and wildlife. Known as endocrine disrupting chemicals (EDCs), these natural and synthetic chemicals may mimic or interfere with the action of natural hormonesâ€Â"thus disrupting the endocrine system. Multiple studies have reported negative effects associated with EDCs on both the health of humans and wildlife; however more information is needed on the reproductive effects that EDCs may pose to wildlife, in particular fish inhabiting these freshwater ecosystems. Fish serve as a useful indicator of the health of an ...
We evaluated the utility of whole embryo culture for the screening technique of the potency of endocrine active chemicals in rat embryos. Rat embryos on embryonic day 11 (ED11) were exposed to two estrogenic chemicals, estradiol benzoate (EB) and diethylstilbestrol (DES), for 42 hr in culture. The treated embryos showed some morphological defects in the cardiovascular system, such as edema around umbilical vessels (EB- and DES-treated groups), enlargement of the heart (EB) and hemorrhage of the head (DES) at high doses. To determine the mediation of estrogen receptors to these morphological defects, we also studied the expression of estrogen receptor a (ER-a) in embryos both by immunohistochemistry and by Western blotting. Immunohistochemistry revealed positive grains stained with anti-ER- a antibody in both the cytoplasm and nucleus of heart and yolk sac in EDs 12 and 13 rat embryos. The staining pattern of anti-ER-a antibody in embryos was different from the positive control, the uterus of ...
I received my PhD from City University of Hong Kong in 2002. After my postdoctoral training with Prof. Rudolf Wu, I continued to work in the same institution as a Lecturer until joining the University of Newcastle in 2009. I am now an academic in the Discipline of Environmental Science and Management in the School of Environmental & Life Sciences (SELS).. My primary research interests are in the Molecular Toxicology of Environmental Stressors and Chemicals. In particular, I am interested in (1) understanding the molecular mechanisms of endocrine disruption caused by hypoxia and environmental chemicals and (2) developing cell- and animal-based assays for the screening and detection of endocrine-disrupting chemicals (EDCs). Overall, my research covers both basic science aimed at understanding the fundamental mechanisms of environmental toxicity and applied science concerned with the development of diagnostic tools for assessing and monitoring environmental toxicity. Outlined below is a summary of ...
I received my PhD from City University of Hong Kong in 2002. After my postdoctoral training with Prof. Rudolf Wu, I continued to work in the same institution as a Lecturer until joining the University of Newcastle in 2009. I am now an academic in the Discipline of Environmental Science and Management in the School of Environmental & Life Sciences (SELS).. My primary research interests are in the Molecular Toxicology of Environmental Stressors and Chemicals. In particular, I am interested in (1) understanding the molecular mechanisms of endocrine disruption caused by hypoxia and environmental chemicals and (2) developing cell- and animal-based assays for the screening and detection of endocrine-disrupting chemicals (EDCs). Overall, my research covers both basic science aimed at understanding the fundamental mechanisms of environmental toxicity and applied science concerned with the development of diagnostic tools for assessing and monitoring environmental toxicity. Outlined below is a summary of ...
Endocrine Disrupting Chemicals (EDCs) are synthetic compounds that alter hormone systems and can cause adverse health effects. Learn more here.
ROCK SPRINGS, Pa. - With water quality in the Chesapeake Bay suffering from excess nutrients and fish populations in rivers such as the Susquehanna experiencing gender skewing and other reproductive abnormalities, understanding how to minimize runoff of both nutrients and endocrine-disrupting compounds from farm fields after manure applications is a critical objective for agriculture.. A new study by researchers in Penn States College of Agricultural Sciences shows that applying manure to crop fields by means of shallow disk injection into the soil rather than traditional surface broadcast significantly reduces estrogens in surface runoff. This finding suggests that manure-application methods can be used to control the mobilization potential of estrogens and points to opportunities for protecting downstream water quality.. The research, published this month in Agriculture, Ecosystems and Environment, also investigated how manure-application methods affected runoff of total dissolved phosphorus ...
The recently developed female leukophore-free (FLFII) strain of Japanese medaka (Oryzias latipes) carries DNA markers for the identification of genotypic sex. Information regarding genotypic sex is useful for tests in which endocrine-disrupting compounds may masculinize or feminize fish. In the present study, methods were developed to automate DNA extraction and profiling for rapid determination of genotypic sex. Adequate amounts of DNA were isolated by robotic extraction procedures from the caudal fin. New primers were developed to include an 18-base pair segment that is in the X chromosome of female medaka but is absent in the Y chromosome of male medaka. Automated profiling methods with 96-well plates permitted analysis of the genomic sex of medaka at rates of up to 500 fish/d. We investigated the sensitivity of the FLFII strain to the feminizing effects of the potent estrogen 17beta-estradiol (E2), and we compared this sensitivity to that of a wild strain that has been used widely in the ...
Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. It is present in a variety of products used daily including food containers, paper, and dental sealants and is now widely detected in human urine and blood. Exposure to BPA during development may affect brain organization and behavior, perhaps as a consequence of its actions as a steroid hormone agonist/antagonist and/or an epigenetic modifier. Here we show that BPA produces transgenerational alterations in genes and behavior. Female mice received phytoestrogen-free chow with or without BPA before mating and throughout gestation. Plasma levels of BPA in supplemented dams were in a range similar to those measured in humans. Juveniles in the first generation exposed to BPA in utero displayed fewer social interactions as compared with control mice, whereas in later generations (F2 and F4), the effect of BPA was to increase these social interactions. Brains from embryos (embryonic d 18.5) exposed to BPA had lower gene ...
Statistical Methods Development & Visual Analytics. [Vignette: Reif et al (2010) Environmental Health Perspectives]. The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery of 467 in vitro, high-throughput screening assays to assess 309 environmental chemicals. One important mode of action leading to toxicity is endocrine disruption, and the U.S. EPAs Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife. The goal of this study was to develop a flexible method to facilitate the rational prioritization of chemicals for further evaluation and demonstrate its application as a candidate decision-support tool for EDSP. Focusing on estrogen, androgen, and thyroid pathways, we defined putative endocrine profiles and derived a relative ...
This work is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of biologically-based risk assessment, as developed form physiologically-based toxicokinetic models. The analysis of this material is proposed as the novel parameters for developing biologically-based models of carcinogenesis, considered to be more relevant to risk assessment than traditional approaches.
The effects of endocrine disruptors can be strongest during critical periods such as fetal development, infancy, adolescence, conception and pregnancy. These are times of important changes that will have long-term consequences for a child (fry, larvae, pup, chick etc.) and its future children. Thousands of chemicals have been found to be endocrine disruptors. Some of them are very resistant to degradation and remain in the environment and in peoples bodies for decades or longer. Many of these are no longer in use even though we can still easily detect them. They were found to be a threat to health and were banned and/or replaced with something less dangerous. There are many other chemicals in use that have not been tested. There are others that are current foci of research and debate. These chemicals were not developed to cause harm to humans (at least not most of them), rather they were found to be harmful after they were already in use. An example that you may be aware of is the plastics ...
Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) and Seveso Womens Health Studies (SWHS) similarities: 1. Both are prospective cohort studies of more highly exposed populations; 2. Both use biomarkers of exposure; and, 3. Both study multiple health outcomes. CHAMACOS and SWHS differences: 1. CHAMACOS focuses on childrens health, SWHS focuses on womens health. 2. CH
Ask your health care provider any questions you may have about how to use Levitra Plus.. STORAGE. Store Levitra Plus at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Levitra Plus out of the reach of children.. MORE INFO:. Active Ingredient: Vardenafil 10mg.. Other Ingredients:. Ginseng stimulates and increases endocrine activity in the body. It increases metabolic activity and relaxes heart and artery movements. Ginseng also stimulates the medulla centers and relaxes the central nervous system. Ginseng also increases more successfully erections, sexual desire and intercourse in comparison with placebo.. L-Arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-Arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation). Together with reduction of blood vessel stiffness L-Arginine ...
Ask your health care provider any questions you may have about how to use Levitra Plus.. STORAGE. Store Levitra Plus at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Levitra Plus out of the reach of children.. MORE INFO:. Active Ingredient: Vardenafil 10mg.. Other Ingredients:. Ginseng stimulates and increases endocrine activity in the body. It increases metabolic activity and relaxes heart and artery movements. Ginseng also stimulates the medulla centers and relaxes the central nervous system. Ginseng also increases more successfully erections, sexual desire and intercourse in comparison with placebo.. L-Arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-Arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation). Together with reduction of blood vessel stiffness L-Arginine ...
Ask your health care provider any questions you may have about how to use Levitra Plus.. STORAGE. Store Levitra Plus at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Levitra Plus out of the reach of children.. MORE INFO:. Active Ingredient: Vardenafil 10mg.. Other Ingredients:. Ginseng stimulates and increases endocrine activity in the body. It increases metabolic activity and relaxes heart and artery movements. Ginseng also stimulates the medulla centers and relaxes the central nervous system. Ginseng also increases more successfully erections, sexual desire and intercourse in comparison with placebo.. L-Arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-Arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation). Together with reduction of blood vessel stiffness L-Arginine ...
Over the last 20 years, endocrine disruption research has shown how chemicals in our environment can profoundly affect development, growth, maturation, and reproduction by mimicking hormones or interacting with hormone receptors. One important mechanism of endocrine disruption is altered gene expression, mediated by inappropriate activation or deactivation of receptors that act as transcription factors.. Yet, receptor-mediated changes in gene expression are just the tip of the iceberg. There are many more mechanisms of gene regulation that are potentially susceptible to alteration by environmental influences. The effect of environmental contaminants on health is a major concern because exposure is associated with a number of diseases, including cancer, diabetes, and infertility.. The purpose of this review is to identify points of gene expression regulation, occurring along the process described by the central dogma (DNA . RNA . protein), that have been shown to be affected by environmental ...
Environmental estrogens are environmental contaminants that can mimic the biological activities of the female hormone estrogen in the endocrine system, i.e. they act as endocrine disrupters. Several substances are reported ...
Learn how NMS Labs can help you with monitoring individuals exposure to toxic substances found in the workplace or in the community, including Endocrine Disruptors, such as bisphenol-A (BPA), and Phthalate Metabolites.
Obesogens are foreign chemical compounds that disrupt normal development and balance of lipid metabolism, which in some cases, can lead to obesity. Obesogens may be functionally defined as chemicals that inappropriately alter lipid homeostasis and fat storage, change metabolic setpoints, disrupt energy balance or modify the regulation of appetite and satiety to promote fat accumulation and obesity ...
Plastic #7 can be tricky because it stands for other which may or may not contain BPA. It is commonly used to label Polycarbonate (PC). The letters PC may be present with the recycling symbol, which would indicate that the product is made with polycarbonate. BPA has been found to be an endocrine disruptor and shouldnt be around pregnant women or young children. Photo by Erik DeFruscio. less ...
That being said, there *are* people out there who *arent* cheating or having a lot of carb creep, and the weight still isnt budging. I forget who said it -- maybe it was Taubes -- but someone said something to the effect of, Low-carb will get you as lean as you can be, but that might not be as lean as you *want* to be. But sometimes even then, like youve said about yourself, you probably *can* be leaner; so the question is, what *else* is the issue, besides just insulin, glucose, & carbs? I was at a seminar this weekend about obesity, and it really is so, so complex. Hormones, endocrine disruptors, gut biome...I do think insulin is the major player, but its certainly not the only one. And once someones got that managed, if the weight still isnt budging, then there are other factors. Part of that could very well be what youre talking about here -- fat cells that are programmed to horde fat, no matter whats going on with insulin. I remember there was a study that pitted a low-fat diet ...
This drives me nuts. Im sorry to contradict other commenters, but I cant stop myself.. 1) Society, media, advertising, and the whole kit and caboodle should stop with the fat-shaming and fat-hatred. Absolutely. Agree 100%.. 2) There are powerful socioeconomic and environmental reasons for obesity. (In the gospel according to quixote, the two biggies by far are advertising and endocrine disruptor pollution. Read the whole blah-blah here if you want.) Poverty is a big factor, but its not causal. Its dependent. Theres been poverty since forever, but there havent always been poor fat people. Thats a modern phenomenon, so it has to be caused by something new and different in the modern environment.. But, in any case, the point that fatness isnt the fat persons "fault": agree, 100%.. 3) Genetics is a big factor. Another agree 100%.. Okay, so, all that said, it is, Im afraid, nonsense to try to believe that scientific evidence does not come down strongly on the side of a diet with lots of ...
Were All Guinea Pigs - We re All Guinea Pigs I dont want to expose the most precious people in my life to an endocrine disruptor. By Jill Richardson A few years ago my world changed when I began dating a single dad whose youngest child was a tod...