J:167617 Song L, Zhao M, Wu B, Zhou B, Wang Q, Jiao K, Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. Dev Dyn. 2011 Jan;240(1):211-20 ...
ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cell migration (ortholog); endocardial cushion development (ortholog); endocardial cushion to mesenchymal transition involved in heart valve formation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); epilepsy (ortholog); FOUND IN host cell nucleus (inferred); nucleus (inferred); ribonucleoprotein complex (inferred)
J:181526 Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, t Hoen PA, Kispert A, Christoffels VM, Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci. 2011 Dec 1 ...
The involvement and potential targeting of EndMT in fibrotic conditions has increased the research demand in the field. Most studies have pursued the use of TGF-β as the main tool for induction of EndMT based on its well-known contribution to endocardial cushion formation during development and fibrotic diseases [1, 26]. However, the lack of a detailed protocol that could be reproduced by the research community, the general assumption that all members of the TGF-β family play similar roles on the induction of EndMT, and that all endothelial cells respond to extracellular signals the same way is not realistic. In the present study, we investigated the effect of two members of the TGF-β family on the induction of EndMT using two different types of human adult endothelial cells. In addition, we tested the effect of hypoxia on the induction of EndMT, as ischemia is an important trigger of tissue fibrosis [27].. One of the first problems we encountered when starting our studies on EndMT was the ...
A fetal heart structure that is the bulging areas in the cardiac septum between the HEART ATRIA and the HEART VENTRICLES. During development, growth and fusion of endocardial cushions at midline forms the two atrioventricular canals, the sites for future TRICUSPID VALVE and BICUSPID VALVE.
A fetal heart structure that is the bulging areas in the cardiac septum between the HEART ATRIA and the HEART VENTRICLES. During development, growth and fusion of endocardial cushions at midline forms the two atrioventricular canals, the sites for future TRICUSPID VALVE and BICUSPID VALVE ...
Rationale: Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease. Objective: To determine the role of canonical Wnt signaling in the myocardium during AVC development. Methods and Results: We utilized a novel allele of β-catenin that preserves β-catenins cell adhesive functions but disrupts canonical Wnt signaling, allowing us to probe the effects of Wnt loss of function independently.¬ We show that loss of canonical Wnt signaling in the myocardium results in tricuspid atresia with hypoplastic right ventricle associated with loss of AVC myocardium. In contrast, ectopic activation of Wnt signaling was sufficient to induce formation of ectopic AV junction-like tissue as assessed by morphology, gene expression, and electrophysiologic criteria. Aberrant AVC development can lead to ventricul¬¬ar preexcitation, a characteristic feature of ...
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).
Definition: VSDs are characterized by a split in the endocardial cushion cells in the interventricular component of the membranous septum which is close to the atrioventricular node.. ...
Embryonic heart development is characterized by dramatic growth and change over a relatively short amount of time, all the while generating unidirectional blood flow. Prior models of endocardial cushion function and their contribution to flow regulation have not accounted for cushion material properties and have been biomechanically oversimplified. The results of the current study link hemodynamic function with myocardial activation and cushion mechanics to show the spectrum of atrioventricular flow regulation during the transition from a single AV lumen to separate right and left atrioventricular connections. Our studies show a defined progression in AV canal mechanics necessary for the transition in cardiac function from a suction-like pump at HH17 to a piston-like pump at HH25. The relatively weak HH17 cushions are propelled in a treadmill-like fashion by the contracting myocardium, which occurs in a quasi-linear fashion along the looped heart tube. During migration, mesenchymal cells secrete ...
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Cat Cushion Cozy - 40 x 30cm A basic cushion. Hard wearing and washable. Has a ribbed border for added comfort. A simple cushion at an unbeatable price Price: Lm 1.75 EUR 4.07 ...
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