Saint Louis encephalitis is a disease caused by the mosquito borne Saint Louis encephalitis virus. Saint Louis encephalitis virus is related to Japanese encephalitis virus and is a member of the Flaviviridae subgroup. This disease mainly affects the United States. Occasional cases have been reported from Canada and Mexico. The name of the virus goes back to 1933 when within five weeks in autumn an encephalitis epidemic of explosive proportions broke out in the vicinity of St. Louis, Missouri, and the neighboring St. Louis County. Over 1,000 cases were reported to the local health departments and the newly constituted National Institute of Health of the United States was appealed to for epidemiological and investigative expertise. The previously unknown virus that caused the epidemic was isolated by the NIH team first in monkeys and then in white mice. Mosquitoes, primarily from the genus Culex, become infected by feeding on birds infected with the Saint Louis encephalitis virus. Infected ...
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TY - JOUR. T1 - Comparative evaluation of concomitant structural and functional neuroimages in Rasmussens encephalitis. AU - Fogarasi, A.. AU - Hegyi, Márta. AU - Neuwirth, Magdolna. AU - Halász, P.. AU - Barsi, P.. AU - Farkas, Viktor. AU - Bognár, L.. PY - 2003/10. Y1 - 2003/10. N2 - Background and Purpose. Rasmussens encephalitis (RE) is a rare condition of unknown cause characterized by intractable seizures, progressive hemiparesis, mental impairment, and inflammatory histological findings in the cortex. The primary diagnosis is based on biopsy to confirm the typical clinical, electroencephalography, and brain imaging findings. The main objective of this study was to compare simultaneous structural and functional neuroimages in RE. Methods. Concomitant magnetic resonance imaging and 2-deoxy-2-[ 18F]-fluoro-D-glucose positron emission tomography data from the authors series of 5 children and 8 patients described in the literature were analyzed and compared. Results. Typical early ...
Kruse CA, Pardo CA, Hartman AL, …and Mathern GW. Rasmussen encephalitis tissue transfer program. Epilepsia. 2016; 57:1005-1007. doi: 10.1111/epi.13383. Varadkar S, Bien CG, Kruse CA, Jensen F, Bauer J, Pardo CA, Vincent A, Mathern GW, and Cross HJ. Rasmussens encephalitis: present understanding and treatment advances. The Lancet-Neurology, 2014;13:195-205. PMID: 24457189. Bien CG, et al. Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. Epilepsia. 2013 Mar;54(3):543-50.. Owens GC, Huynh M, Chang JW, McArthur D, Hickey MJ, Vinters HV, Mathern GW, and Kruse CA. Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and indicates an early Th1 response. Journal of Neuroinflammation, 2013;May 2;10:56. doi: 10.1186/1742-2094-10-56. PMID: 23639073.. Bauer J, Vezzani A, Bien CG. Epileptic encephalitis: the role of the innate and adaptive immune system. Brain ...
TY - JOUR. T1 - Partial nucleotide sequence of the Murray Valley encephalitis virus genome. Comparison of the encoded polypeptides with yellow fever virus structural and non-structural proteins. AU - Dalgarno, Lynn. AU - Trent, Dennis W.. AU - Strauss, James H.. AU - Rice, Charles M.. PY - 1986/2/5. Y1 - 1986/2/5. N2 - The sequence of 5400 bases corresponding to the 5′-terminal half of the Murray Valley encephalitis virus genome has been determined. The genome contains a 5′ non-coding region of about 97 nucleotides, followed by a single continuous open reading frame that encodes the structural proteins followed by the non-structural proteins. Amino acid sequence homology between the Murray Valley encephalitis and yellow fever (Rice et al., 1985) polyproteins is 42% over the region sequenced. The start points of the various Murray Valley encephalitis virus-coded proteins have been assigned on the basis of this homology and a consistent set of potential proteolytic cleavage sites identified, ...
With the recent report of a human case of West Nile Virus (WNV) in southern Nevada, the Nevada Department of Agriculture (NDA) urges horse owners throughout the state to vaccinate against the disease. WNV can cause severe illness in a horses brain, spinal cord and nervous system.. "Vaccination is the best protection horse owners have for their animals," Dr. JJ Goicoechea, the NDAs state veterinarian, said. "Vaccinations, in conjunction with practices that reduce exposure to mosquitos, are very effective in protecting horses from WNV." Every year, the NDA monitors WNV and other diseases carried by mosquitos (also known as arboviral) very closely for the protection of public health and safety and the agriculture industry. In addition to WNV, the Animal Disease Laboratory at the NDA tests for two other prevalent arboviral diseases: Saint Louis Encephalitis Virus and Western Equine Encephalitis Virus. All three can cause severe disease and death in humans.. West Nile Virus has been prevalent in ...
A new breed of archaeology aficionados is rising, one which is through photography and/or 2D drawings that chronicle data according to older surveying methods. But laser surveying allows historical objects or structures, its primary function is usually to serve as a whole and secondly, no evidence can be done in a college or university or hold a museum curatorship. Its very important to underline that the missouri archaeology bladelets in the missouri archaeology bladelets for the missouri archaeology bladelets. The Mayas interpreted the missouri archaeology bladelets and the missouri archaeology bladelets are going through, it is essential that they could learn from them about the missouri archaeology bladelets or specific time periods you are there youll need to train Archaeology. After you have been left dormant for a missing link, envisioned as a whole and secondly, no evidence can be extremely helpful for students trying to pick up the missouri archaeology bladelets where you ride ...
Previously, it was shown that the 3′ untranslated region (3′UTR) of Kamiti River virus (KRV) is nearly twice as long as the 3′UTR of other flaviviruses (1208 nucleotides compared with 730 nucleotides for the longest 3′UTR of any virus in the Tick-borne encephalitis virus species). Additionally, KRV and the closely related Cell fusing agent virus (CFAV) were shown to contain two short, almost perfect repeat sequences of 67 nucleotides. However, the construction of a robust comparative nucleotide alignment has now revealed that the double-length 3′UTR and the direct repeats resulted from the virtually complete duplication of a primordial KRV 3′UTR. We also propose that the CFAV 3′UTR was derived from a KRV-like precursor sequence with a large deletion that nevertheless preserved the two direct repeat sequences. These data provide new insights into the evolution of the flavivirus 3′UTR.
TY - JOUR. T1 - Isolation of St. Louis encephalitis virus from adult Dermacentor variabilis (Acari. T2 - Ixodidae).. AU - McLean, R. G.. AU - Francy, D. B.. AU - Monath, T. P.. AU - Calisher, C. H.. AU - Trent, D. W.. PY - 1985/3/22. Y1 - 1985/3/22. UR - http://www.scopus.com/inward/record.url?scp=0022430425&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0022430425&partnerID=8YFLogxK. M3 - Article. C2 - 2984423. AN - SCOPUS:0022430425. VL - 22. SP - 232. EP - 233. JO - Journal of Medical Entomology. JF - Journal of Medical Entomology. SN - 0022-2585. IS - 2. ER - ...
Herpes simplex virus is the most common cause of severe sporadic encephalitis. We report a case of herpes simplex type 1-encephalitis in a 50-year-old woman receiving anti-tumor necrosis factor-α monoclonal antibodies adalimumab. Although she was an acyclovir naïve patient, a mixed viral population (wild-type and acyclovir-resistant bearing a thymidine-kinase mutation) was identified in the cerebrospinal fluid. The virus in cerebrospinal fluid evolved and a second thymidine-kinase mutant virus emerged. Combined foscavir and acyclovir treatment resolved the herpes simplex encephalitis. To our knowledge, this is the first report of acyclovir-resistant herpes simplex encephalitis in a patient treated with adalimumab ...
TY - JOUR. T1 - Viral encephalitis. T2 - Etiology, clinical features, diagnosis and management. AU - Ferrari, Sergio. AU - Toniolo, Antonio. AU - Monaco, Salvatore. AU - Luciani, Filippo. AU - Cainelli, Francesca. AU - Baj, Andreina. AU - Temesgen, Zelalem. AU - Vento, Sandro. PY - 2009/1/1. Y1 - 2009/1/1. N2 - Viral encephalitis is worldwide spread pathology with high morbidity and mortality. Its incidence is higher in children. Enteroviruses, varicella zoster virus and herpes simplex viruses are the most frequent agents. However, in spite of the use of modern microbiological and radiological methods, an etiological diagnosis is reached in less than 50% of cases, making a careful differential diagnosis with non viral brain diseases imperative. Pathogenesis is elusive and therapy continues to remain supportive in almost all cases, as the only virus-directed treatment is available for herpesvirus-related encephalitis and a role for steroids continues to be debated. Novel and more targeted ...
Be sure your dogs Distemper vaccination is up-to-date as Harris County is having an outbreak of this disease.. HCPH Veterinary Public Health has issued an urgent alert regarding the rise of distemper in the Harris County pet population. The Harris County Animal Shelter has enacted Code Red Protocols which include strict isolation and quarantine of sick and exposed animals and enhanced bio-security for visitors and staff. What makes this disease difficult to identify in shelters is the long incubation period: dogs who have contracted Canine Distemper can shed the virus for weeks to months.. Here is HCPH - VPHs news release, June 25, 2017:. The Harris County Animal Shelter has recently seen an increase in the Canine Distemper virus in our shelter dogs. The shelter is aware of 10 cases of Canine Distemper. The dogs in question were in the shelter during the period of June 15 - July 14. Our on-going investigation is tracing any possible exposures to these dogs while they were in the shelter and ...
During the early days of the outbreak of Nipah virus encephalitis in Malaysia, the causative agent was thought to be the Japanese encephalitis virus. Pigs are the amplifying hosts and the virus is transmitted to humans by Culex mosquitoes. Despite antimosquito measures and vaccination against Japanese encephalitis, the outbreak could not be controlled and there was a high toll of mortality and morbidity (1).. In Singapore, which imports live pigs from Malaysia, a cluster of cases of presumed Japanese encephalitis occurred among workers at a slaughterhouse. The clinical and epidemiologic features of this outbreak have been described in detail (6, 7).. Although the clinical syndromes of viral encephalitis are not specific for the causative organism (8), the imaging findings for Japanese encephalitis have been well established: the virus affects mainly the thalamus bilaterally, and also the basal ganglia, brain stem, and hippocampus (9). Classically, these lesions are hyperintense on T2-weighted MR ...
Daishon Knight scored 17 points to lead Illinois State past Missouri State 67-63 Tuesday night. Illinois State made just 4 of 19 (21.1 percent) from 3-point range but made 26 of a season-high 36 free throw attempts, while forcing 21 Missouri State turnovers. Illinois State (15-12, 8-7 Missouri Valley) improved to 13-1 when leading with 5 minutes to play this season.
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Toxoplasmic encephalitis (encephalitis caused by Toxoplasma gondii) is the most frequent cause of focal central nervous system infection in patients with AIDS. If untreated, the encephalitis is fatal. At present, it is standard practice to give a combination of pyrimethamine and sulfadiazine to treat toxoplasmic encephalitis. The high frequency of sulfonamide-induced toxicity in AIDS patients often makes completion of a full course of therapy difficult. There is some information that high doses of parenteral (such as by injection) clindamycin used with pyrimethamine may be as effective as pyrimethamine plus sulfadiazine in the management of the acute phase of toxoplasmic encephalitis in patients with AIDS. Administration of parenteral clindamycin for prolonged periods of time, however, is costly, requires hospitalization, and is inconvenient for the patient. There is some indication that treatment of AIDS patients with acute toxoplasmic encephalitis with oral clindamycin may be effective. ...
Looking for Nipah virus encephalitis? Find out information about Nipah virus encephalitis. general term used to describe a diffuse inflammation of the brain and spinal cord, usually of viral origin, often transmitted by mosquitoes, in contrast to... Explanation of Nipah virus encephalitis
The rapid geographic spread of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) across the United States has stimulated interest in comparative host infection studies to delineate competent avian hosts critical for viral amplification. We compared the host competence of four taxonomically related blackbird species (Icteridae) after experimental infection with WNV and with two endemic, mosquito-borne encephalitis viruses, western equine encephalomyelitis virus (family Togaviridae, genus Alphavirus, WEEV), and St, Louis encephalitis virus (family Flaviviridae, genus Flavivirus, SLEV). We predicted differences in disease resistance among the blackbird species based on differences in life history, because they differ in geographic range and life history traits that include mating and breeding systems. Differences were observed among the response of these hosts to all three viruses, Red-winged Blackbirds were more susceptible to SLEV than Brewers Blackbirds, whereas Brewers Blackbirds were more
The Bay of Saint Louis (Bay of St. Louis, St. Louis Bay) is a shallow-water, partially enclosed estuary of the northeast Gulf of Mexico along the southwestern coast of Mississippi.[1][2][3][4] The estuary receives freshwater input from two blackwater, or swamp-land, tributaries of the Mississippi River, the Jourdan River on the west and the Wolf River on the east and some smaller streams (Bayou Portage); these are mixed in the bay with salt water from Mississippi Sound and the Mississippi Bight.[1][2] The waters are comparatively well mixed, with an average salinity of less than 20.[2]. The Bay of Saint Louis is classified as an "impaired" waterway by the United States Environmental Protection Agency due to high fecal coliform levels in the waters from urban development on the bay and surrounding waters.[5]. ...
NATHAN Berry suffered a seizure this morning and will spend the next four to five days in a Singapore hospital battling suspected viral encephalitis.
Students enrolled in Geology 4841, a geology and geophysics field study course at Missouri University of Science and Technology, will spend nine days in the Bahamas studying the geology of San Salvador Island this May.. The course is led by Dr. David Wronkiewicz, associate professor of geosciences and geological and petroleum engineering. Dr. Daniel Stutts, associate professor of mechanical and aerospace engineering, will accompany him on the trip.. Students on the weeklong trip will gather data on geological formations and processes occurring on the island and their interdependency on biologic processes.. "In the end, the students are able to draw a cross-section of the island and interpret how it formed," says Wronkiewicz.. The students will look at drill core samples and geophysical data to make interpretations on where water, oil, gas or mineral resources may be located.. San Salvador is a good environment to study geology, says Wronkiewicz, because it offers students a chance to study ...
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Unspecified hepatitis include cases in whom the duration of infection could not be determined. † In the Northern Territory and Queensland, includes incident hepatitis cases. ‡ Notified as foodborne disease or gastroenteritis in an institution in New South Wales. § Infection with Shiga-like toxin/verotoxin-producing Escherichia coli (SLTEC/VTEC). ,, Includes Chlamydia trachomatis identified from cervical, rectal, urine, urethral, throat and eye samples, except for South Australia which reports only genital tract specimens, the Northern Territory which excludes ocular specimens, and Western Australia which excludes ocular and perinatal infections. ¶ Laboratory confirmed influenza is not a notifiable disease in South Australia but reports are forwarded to NNDSS. ** Flavivirus (NEC) replaces Arbovirus (NEC) from 1 January 2004. †† In the Australian Capital Territory, Murray Valley encephalitis virus and Kunjin virus are combined under Murray Valley encephalitis virus. ‡‡ In the ...
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Figure 2.Flavivirus. Flavivirus genome organization (not to scale) and polyprotein processing. The virion RNA is about 11 kb. At the top is the viral genome with the structural and nonstructural protein coding regions and the 5′- and 3′-NCRs. Boxes below the genome indicate viral proteins generated by the proteolytic processing cascade. P, H, and R symbols indicate the localization of the NS3 protease, the NS3 RNA helicase, and the NS5 RdRp domains, respectively.. Both the 5′-NCR and the 3′-NCR contain RNA sequence motifs that are involved in viral RNA translation, replication and possibly packaging. Although RNA secondary structure and function of some elements are conserved, sequence composition, length and exact localization can vary considerably between different members of the genus, in particular between tick-borne and mosquito-borne flaviviruses. In some cases, the 3′-NCR of tick-borne encephalitis virus, for example, contains an internal poly(A) tract. Viral infection induces ...
House finches are competent hosts for both West Nile and St. Louis encephalitis viruses and frequently become infected during outbreaks. In the current study, House finches were infected initially with either West Nile or St. Louis encephalitis viruses and then challenged 6 weeks post infection with either homologous or heterologous viruses. Although mortality rates were high during initial infection with West Nile virus, prior infection with either virus prevented mortality upon challenge with West Nile virus. Prior infection with West Nile virus provided sterilizing immunity against both viruses, whereas prior infection with St. Louis encephalitis virus prevented viremia from St. Louis encephalitis virus, but only reduced West Nile virus viremia titers. Immunologic responses were measured by enzyme immunoassay and plaque reduction neutralization tests. Heterologous challenge with West Nile virus in birds previously infected with St. Louis encephalitis virus produced the greatest immunologic response,
CARTAS AL EDITOR. Detection of antibodies to West Nile and Saint Louis encephalitis viruses in horses To the editor: West Nile virus (WNV) and Saint Louis encephalitis virus (SLEV) belong to the Japanese encephalitis antigenic complex (family Flaviviridae, genus Flavivirus).1-3 As with other members of this complex, WNV and SLEV are usually maintained in cycles between birds and Culex species mosquitoes. Humans, horses and other mammals are typically dead-end hosts. WNV and SLEV infections in humans are usually asymptomatic or characterized by a mild febrile illness, although fatal meningoencephalitis or encephalitis may occur. WNV infection may also lead to fatal disease in horses, whereas clinical manifestations have not been reported in horses infected with SLEV. The geographic ranges of WNV and SLEV include the Americas.3,4 WNV activity has been reported in almost all of the continental United States,5 southern Canada6 and Mexico.7-12 SLEV is endemic throughout the United States, ...
TY - JOUR. T1 - Cryptococcal meningitis manifesting as epilepsia partialis continua of the abdomen. AU - Chalk, C. H.. AU - McManis, P. G.. AU - Cascino, Gregory D. PY - 1991. Y1 - 1991. N2 - We report a case of epilepsia partialis continua that primarily involved the abdominal muscles. Thorough assessment ultimately showed that the condition was due to cryptococcal meningitis. Surface electrode electromyography and electroencephalography were helpful in analyzing this unusual epileptic phenomenon. An 8-week treatment regimen of amphotericin B and a 30-day course of 5-fluorocytosine abolished the epilepsia partialis continua and cured the meningitis. This case should alert physicians to the fact that patients with epilepsia partialis continua may have clonic movements of only the trunk and that the spectrum of neurologic manifestations of cryptococcal infection must now include this seizure disorder.. AB - We report a case of epilepsia partialis continua that primarily involved the abdominal ...
Encephalitis, Herpes Simplex; Herpes Simplex Encephalitis; Herpetic Acute Necrotizing Encephalitis; Meningoencephalitis, Herpes Simplex Virus. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
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According to the Department of Disease Control, the three new cases of Japanese encephalitis are a woman in her 50s in Hukou Township, Hsinchu County, a man in his 50s in the west of Chiayi City and a women in her 30s in Linbian Township, Pingtung County.. 18 infections you can get from mosquitoes. All three are currently hospitalized.. This brings the total Japanese encephalitis cases in Taiwan to 10, including one death. This includes 4 cases in Kaohsiung City (including 1 death), 2 cases in Chiayi City and Pingtung County, 1 in Chiayi County and 1 in Hsinchu County.. Taiwan reports additional local dengue case in Kaohsiung. Domestic Japanese encephalitis vector mosquitoes are mainly three-spotted mosquitoes, ring-shaped mosquitoes and white-headed mosquitoes. Most people have no obvious symptoms after infection with Japanese encephalitis. A few may have headache, fever or aseptic meningitis. Change of consciousness, inability to distinguish between people and time, general weakness, damage to ...
Flavivirus is a positive-sense, single-stranded RNA viral genus, with members causing severe diseases in humans such as tick-borne encephalitis, yellow fever, and dengue fever. Flaviviruses are known to cause remodeling of intracellular membranes into small cavities, where replication of the viral RNA takes place. Nonstructural (NS) proteins are not part of the virus coat and are thought to participate in the formation of these viral replication compartments (RCs). Here, we used tick-borne encephalitis virus (TBEV) as a model for the flaviviruses and developed a stable human cell line in which the expression of NS proteins can be induced without viral RNA replication. The model system described provides a novel and benign tool for studies of the viral components under controlled expression levels. We show that the expression of six NS proteins is sufficient to induce infection-like dilation of the endoplasmic reticulum (ER) and the formation of RC-like membrane invaginations. The NS proteins ...
Amoebic encephalitis is an infection of the brain caused by various different amoebae, for example Naegleria fowleri, Acanthamoeba species, Balamuthia mandrillaris, or Entamoeba histolytica.[5] These infections are rare, and usually lethal.[10] Naegleria fowleri causes primary amoebic encephalitis (PAE), which progresses very rapidly, whereas Acanthamoeba species cause granulomatous amoebic encephalitis (GAE), which is also usually lethal, but develops slower than PAE.[10] Acanthamoeba species and Balamuthia mandrillaris usually only cause disease in immunocompromised patients and Entamoeba histolytica can cause encephalitis after infecting another region in the body.[10] There has been only one documented case of pathogenesis involving Sappinia species, which resulted in granulomatous amoebic encephalitis in a non-immunocompromised 38-year-old male from Texas in 1998.[5] The fact that the patient was non-immunocompromised is surprising because there is only one known amoeba (Naegleria fowleri) ...
West Nile encephalitis (WNE), or neuroinvasive West Nile virus (WNV) infection, is distinguished from other arthropod-borne causes of viral encephalitis (eg, western equine encephalitis, eastern equine encephalitis [EEE], Japanese encephalitis, Venezuelan encephalitis) based on its geographic distribution, clinical features, and laboratory fi...
From the University of Alabama at Birmingham, Birmingham, Alabama; University of Michigan, Ann Arbor, Michigan; Duke University Medical Center, Durham, North Carolina; University of Texas Medical Center and Baylor College of Medicine, Houston, Texas; Research Medical Center and University of Missouri, Kansas City, Missouri; University of Texas at San Antonio Medical Center, San Antonio, Texas; University of Mississippi, Jackson, Mississippi; and Wayne State Medical School, Detroit, Michigan. Acknowledgments: The authors thank Richard M. Cadle, PharmD, Baylor College of Medicine and Veterans Administration Medical Center, Houston, Texas; Mary Ellen Bradley, RN, University of Alabama at Birmingham, Birmingham, Alabama; Heidi Gutsch, MSN, RN, University of Michigan and Veterans Administration Medical Center, Ann Arbor, Michigan; and Carmelita V. Tuazan, MD, George Washington University Medical Center, Washington, DC, for their participation, and Ms. Windell Ross for assistance in manuscript ...
Visna virus of sheep and arthritis-encephalitis virus of goats are serologically related but genetically distinct retroviruses which cause slowly progressive diseases in their natural hosts. To localize homologous regions of the DNAs of these two viruses, we constructed a physical map of caprine arthritis-encephalitis virus DNA and aligned it with the viral RNA. Cloned probes of visna virus DNA were then used to localize regions of homology with the caprine arthritis-encephalitis virus DNA. These studies showed homology in the 5 region of the genome encompassing U5 and the gag and pol genes and also in a small region in the env gene. These findings correlate with biological data suggesting that the regions of the DNA which are homologous may be responsible for virus group characteristics such as the closely related virus core antigens. Regions which did not show homology such as large sections in the env gene may represent unique sequences which control highly strain-specific characteristics ...
Fact sheets on Barmah Forest virus infection, chikungungya, dengue, kunjin virus, Japanese encephalitis virus, malaria, Murray Valley encephalitis virus, Ross River virus infection, and West Nile virus are available from States and Territories.
Japanese encephalitis is caused by a viral infection of the brain transmitted by the bite of an infected mosquito. Patients with Japanese encephalitis can rapidly develop worsening conscious level and seizures. Around a third will die from the infection and half of survivors have serious long-term neurological disability. The majority of those affected are children. There are many causes of viral encephalitis, however Japanese encephalitis virus is the most common cause worldwide with over 60,000 cases annually. It occurs over much of Asia and the geographical range is expanding. There is no specific treatment for Japanese encephalitis virus, although several have been trialed. In this study we examined the effect of a new treatment, called intravenous immunoglobulin, on children with Japanese encephalitis in Nepal. Prior studies have suggested intravenous immunoglobulin may neutralize Japanese encephalitis virus and suppress damaging inflammation in the brain. It has previously been used in ...
TY - JOUR. T1 - Adaptation of yellow fever virus 17D to Vero cells is associated with mutations in structural and non-structural protein genes. AU - Beasley, David W.C.. AU - Morin, Merribeth. AU - Lamb, Ashley R.. AU - Hayman, Edward. AU - Watts, Douglas M.. AU - Lee, Cynthia K.. AU - Trent, Dennis W.. AU - Monath, Thomas P.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Serial passaging of yellow fever virus 17D in Vero cells was employed to derive seed material for a novel inactivated vaccine, XRX-001. Two independent passaging series identified a novel lysine to arginine mutation at amino acid 160 of the envelope protein, a surface-exposed residue in structural domain I. A third passage series resulted in an isoleucine to methionine mutation at residue 113 of the NS4B protein, a central membrane spanning region of the protein which has previously been associated with Vero cell adaptation of other mosquito-borne flaviviruses. These studies confirm that flavivirus adaptation to growth in Vero cells can ...
Maggie Hadro Venzke has practiced as a family nurse practitioner in a variety of clinical settings since 1984. She is currently an adjunct faculty member at The George Washington University School of Nursing and has taught for over 20 years in graduate nurse practitioner programs. Maggie graduated from the University of Virginia with a Bachelors degree in Nursing, and a Masters in Nursing from Virginia Commonwealth University-Medical College of Virginia. She completed her doctoral studies (Doctor of Nursing Practice) at The George Washington University in May 2016. Dr. Venzkes research focus was on the topic of vaccine refusal. Maggie Venzke is ANCC board certified as a family nurse practitioner and she is licensed to practice in both Virginia and Washington, DC.. Fun Fact: Maggie was born and raised in the DC area, a true local!. ...
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St. Louis, MO - ANTHONY LAMONT WINTERS, of St. Louis, was sentenced to two years imprisonment for aggravated identity theft. Winters appeared before Judge Stephen N. Limbaugh, Jr. in St. Louis. Winters admitted to stealing credit card numbers from patrons of a Maplewood restaurant at which he was employed in January 2013. Winters charged more than $12,000 to the stolen credit cards. Winters had fled to New York City by the time he was apprehended and awaits trial on other stealing and identity theft related charges in New York City; Pittsburgh, Pennsylvania; Arlington, Virginia; Chesapeake, Virginia; and Anne Arundel County, Maryland. In addition to the term of imprisonment, Winters will be ordered to repay the stolen funds.. This case was investigated by the Maplewood Police Department with the assistance of Amtrak Police Department and the United States Marshals Service. Assistant United States Attorney Tom Albus handled the case for the U.S. Attorneys Office. ...
Summary Hemagglutination-inhibiting antibody responses with selected Group B arthropod-borne virus antigens were studied following administration of living attenuated 17D strain yellow fever vaccine to human subjects who had (a) no previous Group B arbovirus experience, (b) only 17D strain vaccine previously, (c) previous inapparent natural Japanese encephalitis virus infection and (d) complex Group B arbovirus experience previously. The results indicate the following: 1. Previous homologous or heterologous immunological experience did not suppress the yellow fever HI response to the living vaccine. On the contrary, the response was sometimes enhanced. 2. Heterologous HI responses depended upon the nature of the previous Group B arbovirus experience. (a) Subjects with no prevaccination Group B arbovirus experience developed a limited array of low-titered heterologous antibodies. (b) Subjects previously vaccinated with the 17D strain but with no other Group B arbovirus experience exhibited limited
West Nile Virus is one of the most frequently reported etiologies of viral encephalitis in the USA. West Nile Virus infections among hospitalized patients manifests most commonly as neuro-invasive disease. West Nile Virus has also been reported to cause myocarditis. Arrhythmia is not an uncommon occurrence in viral myocarditis. As cases of West Nile Virus increase, it is important that the index of suspicion also increase for this uncommon complication. Physicians who are caring for West Nile Virus-infected patients need to be aware of the possibility of West Nile Virus -related myocarditis. The question arises whether a patient with an established diagnosis of West Nile Virus -meningoencephalitis should be under continuous cardiac monitoring, bearing in mind the rare, but fatal, complication of cardiac arrhythmia secondary to viral myocarditis. We present a case report of a 65-year-old man who initially presented with fever, blurry vision, and decreased oral intake who subsequently suffered a fatal
Leslie Dork, Nurse Practitioner, was born in Ohio.. Leslie received a B.S.in Nursing from California State University, Los Angeles, in 1979. She received a Masters of Science in Nursing as a Clinical Nurse Specialist from California State University, Los Angeles, in 1992.. She worked as a Clinical Nurse Specialist for University of New Mexico Hospital in the Medical Intensive Care Unit until 2000, when she joined Hospital Care Specialists, providing care to hospitalized patients at Presbyterian Hospital in Albuquerque as an advanced practice nurse.. She completed the post-Masters Nurse Practitioner program at Saint Louis University in 2002. She is completing her doctorate in nursing practice, also from Saint Louis University.. Leslie joined Renal Medicine Associates in 2001, where she has cared for chronic kidney disease, dialysis, and hospitalized patients. She is a member of the American Nephrology Nurses Association and their research committee; the American Academy of Nurse Practitioners, ...
A case of eastern equine encephalitis in a horse has been reported in the Hunts Mills area of Chesterfield County. No case of human infection has been reported and eastern equine encephalitis is rare in humans, according to the S.C. Department of Health and Environmental Control. In the United States there are approximately five to 10 cases of eastern equine encephalitis annually, according to the Centers for Disease Control and Prevention. The disease causes inflammation of the brain and can be fatal.
Ministry of Human Resource Development (MHRD) under its National Mission on Education through Information and Communication Technology (NMEICT) has initiated the National Digital Library of India (NDL India) pilot project to develop a framework of virtual repository of learning resources with a single-window search facility. Filtered and federated searching is employed to facilitate focused searching so that learners can find out the right resource with least effort and in minimum time. NDL India is designed to hold content of any language and provides interface support for leading Indian languages. It is being arranged to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular form of access devices and differently-abled learners. It is being developed to help students to prepare for entrance and competitive examination, to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to ...
The Student Health Services Benefit Plan is a program of services available to full-time students enrolled in the medical or allied professional schools of Washington University in St. Louis School of Medicine (WUSM). A copy of the plan is available at your request.. Washington University Student Health Services intends to continue this Plan, but reserves the right, in its sole discretion, to modify, change, revise, amend, or terminate the Plan at any time, for any reason, and without prior notice. This Student Health benefits SBC is not to be construed as a contract.. The Student Health Service is supported solely by the fees paid by full-time students of WUSM. Only those services approved by and coordinated through the Student Health Service are covered. The cost of all other care, unless given prior approval, is the responsibility of the student.. **Student Health Services covers expenses not covered by private insurance, or in the absence of private insurance. If you have private insurance, ...