Recent studies have suggested that the substance P (tachykinin NK(1)) receptor may be a pharmacological target for the treatment of mood disorders. Here, the effects of electroconvulsive shock on tachykinin NK(1) receptor gene expression in the rat brain was investigated. Rats received either a single electroconvulsive shock or five shocks on alternate days. Quantitative autoradiography with [(125)I]Bolton Hunter-substance P, and in situ hybridisation histochemistry, were used to measure tachykinin NK(1) receptor-binding site densities and mRNA abundance, respectively. Densities of tachykinin NK(1) receptor-binding sites were significantly increased in the cerebral cortex following repeated electroconvulsive shock compared to sham treated animals. Densities remained unchanged in the hippocampus, striatum and amygdala. Neither single nor repeated electroconvulsive shock altered tachykinin NK(1) receptor mRNA in the brain regions examined. Hence, repeated electroconvulsive shock increases tachykinin NK(1)
BioAssay record AID 1096268 submitted by ChEMBL: Anticonvulsant activity in Mus musculus Swiss albino (mouse) assessed as protection against maximal electroshock-induced seizure at 300 mg/kg, ip measured at 0.5 hr.
Seizure susceptibility to lidocaine was investigated in rats which had received repeated ECS (electroconvulsive shock). In the first experiment three groups of rats received an ECS daily for 18 days, an ECS weekly for 18 weeks, and 18 sham treatments, respectively. Twelve weeks after the last ECS all rats received a lidocaine challenge (LC) in the form of an intraperitoneal (IP) injection of lidocaine (65 mg/kg). After the injection the animals were observed for occurrence of motor seizures. A total of 67% (10/15), 47% (7/15), and 0% (0/18) of the daily, weekly, and sham groups, respectively, had motor seizures in response to the LC. In the second experiment five groups of rats received an ECS daily for 0, 1, 6, 18, and 36 days, respectively. Eighteen weeks after the last ECS all rats received an LC and 0% (0/15), 13% (2/15), 20% (3/15), 53% (8/15), and 58% (7/12), respectively, developed seizures in response to the LC. In the third experiment two groups of rats received daily ECS and sham-ECS, ...
Seizure susceptibility to lidocaine was investigated in rats which had received repeated ECS (electroconvulsive shock). In the first experiment three groups of rats received an ECS daily for 18 days,...
Modulation of central 5-HT receptor sensitivity is implicated in the therapeutic response to electroconvulsive shock (ECS). Altered 5-HT receptor expression may play a role in this process. We have measured the mRNAs encoding 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptors, and the 5-HT transporter, in rat brain after single ECS, repeated ECS, and 3 weeks after repeated ECS. Hippocampal 5-HT1A receptor mRNA was decreased in CA4 and increased in dentate gyrus by single or repeated ECS, with parallel alterations in [3H]8-OH-DPAT binding site densities. Repeated ECS increased cortical [3H]ketanserin binding and 5-HT2A receptor mRNA. The other mRNAs were unchanged. The results show that ECS has subtype specific, anatomically discrete, and temporally selective effects on 5-HT receptor expression.
About 1% of our population suffers from various forms of epilepsies, but present therapy options for juvenile and adult epilepsies are less than ideal. Tolerance to some drugs (e.g. benzodiazepines) develops rapidly, side-effects of anticonvulsant therapy may be disturbing, and many patients respond only partially to therapy. There is an urgent need to develop new drugs. To date, the anticonvulsant potential of new drugs is characterized in a first step in vitro and in a second step always in vivo. At present over 50 animal models are available. Seizures that phenomenologically resemble convulsions in humans are elicited in animals (mostly rats or mice) either physically, by maximal electroshock or auditory stimulation, or chemically. Currently, the maximal electroshock seizure (MES) and the pentylentetrazol (PTZ) tests are the most widely used models. Seizure models are also used in toxicological testing, to rule out unwanted proconvulsant or epileptogenic side-effects of other, unrelated ...
A mosquito killing apparatus includes an electroshock unit to which a high voltage applies, a heater to generate heats, a carbon dioxide (CO2) gas introduction inlet connected to discharging portions for discharging carbon dioxide (CO2) gas around the electroshock unit, and a protection cover provided outside the electroshock unit for covering the electroshock unit. The carbon dioxide (CO2) gas introduction inlet can be connected to carbon dioxide (CO2) gas generating means of various types, and a carbon dioxide (CO2) gas staying unit is formed around the electroshock unit to stay the carbon dioxide (CO2) gas introduced from the carbon dioxide (CO2) gas introduction inlet to surely electrocute attracted mosquitoes.
I have gotten the orders to revoke and transport. I spoke with my public defender. He said the sheriff can come at any minute. My attorney has written an affidavit challenging the need to continue ECT. I also have an appointment with a new psychiatrist this weekend who supports my right to say no to electroshock.". Said Elizabeth: "They claim they are trying to save my life. But maybe they are trying to save their image, now that they know Im challenging them and I have an organizations backing.". Elizabeth added, "Im in very good mental health. Im active, eating, sleeping, doing everything. Im in deep appreciation of MindFreedom for putting out alerts.". Her husband Robert (see photo of the couple above) agreed: "Elizabeth doesnt need electroshock. Shes been fine, active. Weve been doing things together. Shes pretty sharp, but her memory is still off from the electroshock. Im angry and upset about this court order for her to have forced outpatient electroshock.". For the latest ...
Principle: Meritt and Putnam developed the MES test and discovered the anticonvulsive effect of Diphenyl hydantoin using this test in 1938. Phenytoins subsequent success in the clinical management of generalized tonic clonic seizures provided the...
Electric Foot Massager Machine India 2020 with Heat for Calf Pain Relief is a hot-selling massager with a universal design leg pain massager which can be...
During the interrogation, it is even more important than confessions "to break you from the inside," maintains Wassim, who was tortured for approximately 18 hours on the whole and released without having admitted anything relevant. As a consequence of the electroshocks, Wassim suffered a form of impairment of hearing for the following two months. "During the whole interrogation I had one guy on my right side, letting me hear the rumor of an electroshock baton, which can hurl your body 3 meters away," recalls crying Wassim, "another guy was on my left side and he kept on beating me on the head…even if had confessed, they would have done this, to scare me." After the first round of interrogations, they took him to another room, where his naked body was sprinkled with cold water and electroshocked with a baton for nearly three hours." This routine of interrogation, humiliation and torture was organized in three phases, with the last electroshock session lasting almost 9 hours. After this, he was ...
The MOTHERS Act is named for Melanie Stokes, who committed suicide in 2001. She was undergoing postpartum psychiatric treatment with a myriad of drugs in addition to electroshock therapy. Apparently they still use electroshock treatment. Senate majority leader Harry Reid (D-NV) brought this bill called the Mothers Act "Advancing America Priorities Act (S.3297) up before the recess in late July as part of the Coburn Omnibus Package. The bills lead sponsor is Senator Robert Menendez (D-NJ), who has accepted more than $300,000 from pharmaceutical donors during the last election cycle. It is also co-sponsored by Senator Barak Obama (D-ILL), Hillary Clinton (D-NY), and Barbara Boxer (D-CA) among others. The bill is designed to screen and treat pregnant and new mothers across the U.S. at risk for mental disorders. This could put virtually every mother and every child on anti-depressants (SSRIs) in America (also see ssristories.com). Many of the groups backing the bill also receive funds from or ...
After 22 years as one-half of the notorious art duo, the Chapman brother is now releasing his debut album. Here he tells us why this isnt sound art, but music proper.
The Associated Press covered MindFreedoms protests about Ray Sandfords ongoing, involuntary, outpatient electroshock. Unfortunately, the AP quotes four
Dear All, I just want to know that how long could the competent cells be stored at -70degC? I had prepared the competent cells (for electroshock tranformation) just one month back. Thanks for your input in advance. with best regards, Sulakshana ...
Be warned: its a LONG list. If you have to break for dinner or electroshock therapy, Ill understand. (Just use the handy numbers to remember your place in the list, so you can pick up where you left off ...
4Animal Production and Management, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781 022, India and 5Department of Pharmacology, GMCH, Guwahati 781 006, India. Received 9 October 2012; revised 13 March 2013. Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied using actophotometer and anticonvulsant effect was studied using maximal electroshock-induced seizures and pentylenetetrazole-induced seizures in mice. Single oral administration of MEAB at different doses (100, 300 and 600 mg/kg, ip) significantly increased the number and duration of head poking in the HB test; rearing, assisted rearing and number of square traveled in the OF test; entries and time spent in open ...
TY - JOUR. T1 - Brain lipopolysaccharide preconditioning-induced gene reprogramming mediates a tolerance state in electroconvulsive shock model of epilepsy. AU - Amini, Elham. AU - Golpich, Mojtaba. AU - Farjam, Abdoreza S.. AU - Kamalidehghan, Behnam. AU - Mohamed, Zahurin. AU - Mohamed Ibrahim, Norlinah. AU - Ahmadiani, Abolhassan. AU - Ali, Raymond Azman. PY - 2018/5/1. Y1 - 2018/5/1. N2 - There is increasing evidence pointing toward the role of inflammatory processes in epileptic seizures, and reciprocally, prolonged seizures induce more inflammation in the brain. In this regard, effective strategies to control epilepsy resulting from neuroinflammation could be targeted. Based on the available data, preconditioning (PC) with low dose lipopolysaccharide (LPS) through the regulation of the TLR4 signaling pathway provides neuroprotection against subsequent challenge with injury in the brain. To test this, we examined the effects of a single and chronic brain LPS PC, which is expected to lead to ...
BioAssay record AID 621652 submitted by ChEMBL: Protective index, ratio of TD50 for albino Sprague-Dawley rat to ED50 for albino Sprague-Dawley rat by maximal electroshock seizures test.
Exacerbated hippocampal activity has been associated to critical modifications of the intracellular signaling pathways. We have investigated rapid hippocampal adaptive responses induced by maximal electroshock seizure (MES). Here, we demonstrate that abnormal and exacerbated hippocampal activity induced by MES triggers specific and temporally distinct patterns of phosphorylation of extracellular signal-related kinase (ERK), mammalian target of rapamycin complex (mTORC) and Akt/glycogen synthase kinase-3 (Akt/GSK-3) pathways in the mouse hippocampus. While the ERK pathway is transiently activated, the mTORC1 cascade follows a rapid inhibition followed by a transient activation. This rebound of mTORC1 activity leads to the selective phosphorylation of p70S6K, which is accompanied by an enhanced phosphorylation of the ribosomal subunit S6. In contrast, the Akt/GSK-3 pathway is weakly altered. Finally, MES triggers a rapid upregulation of several plasticity-associated genes as a consequence exacerbated
BOSTON, MA - Passing an electric current through the brain to induce a seizure is not everyones idea of a therapeutic procedure. So its no surprise that…
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
6. Government support. Not only does the federal government stand by passively as psychiatrists continue to electroshock American citizens in direct violation of some of their most fundamental freedoms, including freedom of conscience, freedom of thought, freedom of religion, freedom of speech, freedom from assault, and freedom from "cruel and unusual punishment," the government also actively supports electroshock through the licensing and funding of hospitals where the procedure is used, by covering ECT costs in its insurance programs (including Medicare), and by financing ECT research (including some of the most damaging ECT techniques ever devised). A recently published study provides an example of such research. The ECT experiment, which was conducted at Wake Forest University School of Medicine/North Carolina Baptist Hospital, Winston-Salem, between 1995 and 1998, reports the use of electric current at up to 12 times the individuals convulsive threshold on as many as 36 depressed patients. ...
Los Angeles, California (PRWEB) May 10, 2016 -- The American Psychiatric Association (APA) has called on the Food and Drug Administration (FDA) to reclassify
Is - Of the physiologic effects of the drug, the threshold to electroshock is lowered by reserpine but meprobamate has a blocking action on electroshock.
When the international mental health watchdog Citizens Commission on Human Rights (CCHR) took a stand at the annual convention of the American Psychiatric Association (APA) against
While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD.In the study, researchers administered doses of the opioid morphine to a group of 22 mice for one week, then gave the mice relatively strong foot shocks. After the morphine wore off, the mice were given mild electric foot shocks. These mice showed a substantially longer "freezing response" than a second, control group of 24 mice t ...
And to be sure, when tested this way, many alternative therapies and supplements, as currently offered, will turn out to be totally ineffective, but at least they will have been evaluated properly, on their own terms. I fully understand that much of what is available in the world of holistic medicine is pure woo woo claptrap, but then, as weve already seen, so are many accepted medical treatments. Beyond that, though, it also needs to be understood that much that appears to be woo woo claptrap actually works -- just not for any reason currently understood…by anyone. That doesnt mean it doesnt work, or cant work…just that we dont yet know why it works. Our science is not yet wise enough to understand it. But is that really any different than much of medicine? Take electroconvulsive therapy (aka electroshock therapy) which has been around since the 1930s. No one knows for sure why it does what it does -- only that it does it. There are theories, of course, that have appeared and ...
Question - Pains like electric shock on left arm. I have never had surgery or injuries. Ask a Doctor about diagnosis, treatment and medication for Chest pain, Ask an Orthopaedic Surgeon
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.. These are not all the possible side effects of Rebif. For more information, ask your healthcare provider or pharmacist.. Call your doctor for medical advice about side effects.. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.. Indication. Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS.. US-INF-0814- ...
Electroshock therapy is definitely not something most people want, but a little zap might help you with your SAT scores, according to a new study. The study, done by esearchers at Britains Oxford University, showed that treatment with a low electric current could enhance math score, up to as much as six months. In the study, 15 student volunteers...
I am a confused person making what my friend and fellow artist Nick Stolle called "forlorn propoganda." Lots of energy but no guide. Energy free for the taking. Placeholders and stand ins. Signals. Precoded Symbols. Marking a territory, taking up space. Enter new word here. Name it ambiguity. Single it out as a locatable and symbolic, psychological space: Anxiety ridden AMBIGUITY. Flags to urge on and usher in the future. Symbols for the not yet made, a coming production. Magic symbols that mark a jumping off point, an independence, a personal renaissance, a more free, more humble, more hopeful version of myself. A call to war. Electroshock for the rebel flag and its defenders, but also anathema to the new world beckoned forth by the good intentioned, liberal gentlemen. Hello future strikes and refusals. Hello fragile collective of friends. A new flag needs a new subjectivity. A flag either rejects you or gains your allegiance. This was the goal of abstraction in painting, to reject you, then ...
the Agency turned to Dr Ewen Cameron, a respected psychiatrist who served as president of the Canadian, the American, and the World Psychiatric Association before his death in 1967. Cameron also directed the Allain Memorial Institute at Montreals McGill University, where he developed a bizarre and unorthodox method for treating schizophrenia. With financial backing from the CIA he tested his method on 53 patients at Allain. The so-called treatment started with sleep therapy, in which subjects were knocked out for months at a time. The next phase, depatterning, entailed massive electroshock and frequent doses of LSD designed to wipe out past behavior patterns. Then Cameron tried to recondition the mind through a technique known as psychic driving. The patients, once again heavily sedated, were confined to sleep rooms where tape-recorded messages played over and over from speakers under their pillows. Some heard the message a quarter of a million times ...
Italian anatomist L. Galvani proved the existence of bio-electrical force within living human tissues, in the late 1700s. Since then, a lot of other scientists have proposed different theories about this phenomenon. Researchers suggest that due to physiological disturbances in a womans body during menopause, the fluctuations of hormones have a direct effect on the nervous system of the body. This results in sensations of electric shocks in the body that last for a short span of time.. However, in case of Asha devi, a housewife residing in the northern part of Kolkata (West Bengal), the family members are experiencing electric shocks from her. Friday, the 6th of March 2015 was a different day for Asha devis family. Her child touched her hands and suddenly got electric shocks. Asha devi also felt the shock but ignored it. How would you feel, if you feel electric shocks out of nowhere, from your own body or your mothers body? We can well imagine, that it would be the weirdest thing we can think ...
A rail worker survived a 750-volt electrical shock yesterday in what appeared to be another serious safety lapse at SMRT.. Read more at straitstimes.com.
Electric shocks happen for a number of reasons, such as discarded electric cables, broken circuits, faulty electrical wiring, or wet circuits.
Online Doctor Chat - Getting kind of electric shock in hand fingers. Is it a nerve issue?, Ask a Doctor about uses, dosages and side-effects of Nerve, Online doctor patient chat conversation by Dr. Shanthi.E
i,ve recently been having problems with what feels like nerve pain at the bottom of my back, right hand side, its starting to send like an electric shock sensation.....
After four years of campaigning, the Kennel Club is delighted to announce that the Welsh Assembly has now banned the use of electric shock collars across Wales
Do you have burns? Learn more about how to take care of a burn! Brought to you by Sugarloaf Urgent Care, serving the areas of 30044
[img src=innovate.bta-nxt.dcp-bta._electric-shock-drowning._aquabot.001.jpg width=437 alt=the Aquabot] The Aquabot with one LEGO NXT robot, two Vernier NXT Sensor Adapters, and two Vernier Current Probes This year, the FIRST® LEGO® League competition theme was
Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure - Volume 29 Issue 6 - Maria Ekemohn, Marie Kjær Nielsen, Matilda Grahm, Anders Tingström, Birgitte Kousholt, Gregers Wegener, Cecilie Bay-Richter
TY - JOUR. T1 - Dissociation of analgesic and gastrointestinal effects of electroconvulsive shock-released opioids. AU - Galligan, James J.. AU - Porreca, Frank. AU - Burks, Thomas F.. PY - 1983/7/25. Y1 - 1983/7/25. N2 - Activation of endogenous opioid systems by electroconvulsive shock (ECS) produced naloxone-reversible thermal analgesia (52 °C hot plate) 5 min after ECS administration. Although pioid peptides injected intracerebroventricularly have previously been found to inhibit gastrointestinal motility, ECS treatment did not affect gastric emptying, small or large intestinal transit. These results suggest that centrally-mediated opioid analgesia and changes in gastrointestinal motility are initiated through independent mechanisms.. AB - Activation of endogenous opioid systems by electroconvulsive shock (ECS) produced naloxone-reversible thermal analgesia (52 °C hot plate) 5 min after ECS administration. Although pioid peptides injected intracerebroventricularly have previously been ...
The immunomodulatory effects of the ethanol extract of Gynostemma pentaphyllum (GP-EX) were examined in electric footshock (EFS)-stressed mice. The mice were orally administered various doses of GP-EX for 7 days before exposure to EFS (duration: 3 min, interval: 10 s, intensity: 2 mA) once a day from day 8 for 14 days with continuous daily feeding of GP-EX. Oral administration of GP-EX to mice prevented EFS stress-induced immunosuppression as determined by the lymphoid organ (thymus and spleen) weight and cellularity. In addition, oral administration of GP-EX restored EFS-suppressed functional properties of mature lymphocytes in terms of concanavalin A-induced proliferation of splenocytes and lipopolysaccharide-induced cytokine production (TNF-α, IL-1β). Furthermore, we found that mice that were orally administered with GP-EX generated much more potent ovalbumin-specific cytotoxic T lymphocyte responses upon intravenous ovalbumin injection compared to the untreated controls. These results demonstrate
A series of fluorinated enaminones have been synthesized from the condensation of 5-(trifluoromethyl)-1,3-cyclohexanedione and various amines via the synergistic effect of p-toluenesulfonic acid/acetic acid. The activity of 3-(4-chlorophenylamino)-5-(trifluoromethyl)cyclohex-2-enone (ADD 386002) and 3-(benzylamino)-5-(trifluoromethyl)cyclohex-2-enone (ADD 386001) have been established by our research group as lead compounds with significant anticonvulsant activity in the maximal electroshock (MES) seizure test model. The synthesis of these enaminones will help to advance the chemistry of these compounds as well as provide insight to their structural activity relationships, as potential antiepileptic agents. Using the above procedure, we completed the synthesis of fourteen new fluorinated enaminones containing substituted phenyl and heteroaromatic rings. All 14 compounds were characterized by NMR and GC/MS. The lipophilicity of each compound was calculated in order to determine the membrane
amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;div class="statcounter"><a title="tumblr visit counter" href="http://statcounter.com/tumblr/" target="_blank"><img class="statcounter" src="http://c.statcounter.com/4311352/0/e2e03977/1/" alt="tumblr visit ...
A method for external treatment of dysrhythmias including fibrillation of a patients heart utilizes an externally located control box which generates electrical waveforms including shocks of variable energy content sufficient for terminating the dysrhythmias. A lead having transvenous defibrillation electrodes is inserted through a portion of the patients venous system to position the electrodes to produce an electric field vector through the patients heart when an electrical shock of sufficient energy content is applied across the electrodes. The control box is electrically connected to the lead to deliver electrical shocks from the control box to the electrodes, and to deliver a representation of the patients ECG waveform to the control box. A display screen on the control box aids in synchronously triggering the electrical shocks in response to detection of the QRS complex of the ECG waveform. The energy content of each electrical shock is adjusted from the control box to a value within a range
ROCHESTER - An East Rochester man received a serious electrical shock this morning after climbing a telephone pole to remove a branch from the power lines next to his home.The man, a resident of Periwinkle Drive, fell 25 to 30 feet after the shock around 11:30 a.m., according to Fire Lt. Ken Chick. He was transported by Frisbie Memorial Hospital ambulance to Skyhaven Airport, and then flown by helicopter to Massachusetts General Hospital in Boston.Chick said hes not aware whether
Electrical shock accidents occur frequently in Boston and throughout Massachusetts. Contact an attorney if you have been involved in an accident.
Get information, facts, and pictures about Electric Shock Injuries at Encyclopedia.com. Make research projects and school reports about Electric Shock Injuries easy with credible articles from our FREE, online encyclopedia and dictionary.