BACKGROUND: Electrochemotherapy describes the use of electric pulses to enhance chemotherapy uptake, and has proven highly efficient in treating cutaneous metastases. Patients referred for electrochemotherapy present with diverse clinical pictures, from multiple small lesions to large, ulcerated lesions. Post-electrochemotherapy pain has been observed in some patients. The objectives of this study were to evaluate pain scores before and after electrochemotherapy, and to investigate if patients at risk of post-procedure pain could be identified. METHODS: Seven cancer centres in the International Network for Sharing Practices on Electrochemotherapy (INSPECT) consecutively and prospectively reported to a common database. Electrochemotherapy consisted of intratumoural or intravenous injection of bleomycin, followed by delivery of electric pulses in local or general anesthesia. RESULTS: Of 121 patients 39% had metastatic melanoma, 18% squamous cell carcinoma, 16% breast cancer, 13% basal-cell ...

TY - JOUR. T1 - Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy. AU - Gehl, J.. AU - Geertsen, P. F.. PY - 2000/12/1. Y1 - 2000/12/1. N2 - Electric pulses can cause transient permeabilization of cell membranes (electroporation) and this can be utilized to increase the uptake of chemotherapy (electrochemotherapy). Preclinical studies have shown that in vivo electroporation causes transient shut down of blood flow both in normal and, in particular, malignant tissues. We report the successful palliation of a malignant melanoma patient with bleeding skin metastases using electrochemotherapy. In an on-going study of combined electrochemotherapy and low dose interleukin-2, one patient with bleeding skin metastases was included. Nine skin metastases, of which seven were ulcerated, were treated. After intratumoral bleomycin injection, needle electrodes with two arrays 4 mm apart were inserted into the tumours. Eight square wave electric pulses each 99 μs ...

Electrochemotherapy is a type of chemotherapy that allows delivery of non-permeant drugs to the cell interior. It is based on the local application of short and intense electric pulses that transiently permeabilize the cell membrane, thus allowing transport of molecules otherwise not permitted by the membrane. Applications for treatment of cutaneous and subcutaneous tumors have reached clinical use by utilizing drugs such as bleomycin or cisplatin). Electrochemotherapy with bleomycin was used to treat a patient for the first time in 1991 at the Institute Gustave Roussy in France, while electrochemotherapy with cisplatin was used to treat for the first time in 1995 at the Institute of Oncology, Ljubljana, Slovenia. Since then, more than 4000 patients were treated with electrochemotherapy all over the world (Australia, Austria, Belgium, Bulgaria, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Mexico, Nicaragua, Poland, Portugal, Slovenia, Spain, Sweden, UK, USA). Recently, new ...

TY - JOUR. T1 - European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project. T2 - Results from the treatment of mucosal cancers. AU - Plaschke, Christina Caroline. AU - Bertino, Giulia. AU - McCaul, James A.. AU - Grau, Juan J.. AU - de Bree, Remco. AU - Sersa, Gregor. AU - Occhini, Antonio. AU - Groselj, Ales. AU - Langdon, Cristobal. AU - Heuveling, Derrek A.. AU - Cemazar, Maja. AU - Strojan, Primoz. AU - Leemans, C. Rene. AU - Benazzo, Marco. AU - De Terlizzi, Francesca. AU - Wessel, Irene. AU - Gehl, Julie. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Aim Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours. Patient and methods Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with ...

Oesophageal cancer is on the rise in the western world and the disease has a poor 5-year survival prognosis below 20 %. Electrochemotherapy is a treatment where a chemotherapeutic drug is combined with locally applied electrical pulses, in order to increase the drugs cytotoxicity in malignant cells. This study presents the first results with electrochemotherapy treatment in esophageal cancer.. ...

The study will be conducted on patients with colorectal cancer with synchronous or metachronous liver metastases. Included will be 10-15 patients.. Predominantly, patients with synchronous metastases will be included into the study. These patients present liver metastases at the time of primary tumor resection. Electrochemotherapy will be performed on one metastasis not more than 3 cm in largest diameter at the time of the primary tumor operation, but patients have to have at least 2 to 8 metastases. These metastases will be aimed to be resected in the following operation. It is a standard procedure that liver metastases are resected 2-3 months after the primary tumor resection, in the meantime they are on standard chemotherapeutic protocol (FOLFOX, FOLFIRI, Capecitabine). Only in the case of solitary metastasis smaller than 3 cm in diameter, it is resected during the resection of the primary tumor. In the study additional antitumor effectiveness of electrochemotherapy to other treatment ...

Electroporation (EP) techniques, used alone (Irreversible Electroporation, IRE) or in combination with anti-cancer drugs (Electrochemotherapy, ECT), have been shown to be effective in the treatment of several types of cancers. The efficacy of ECT and IRE is well demonstrated for the treatment of non-superficial tumor metastases, and it depends on the applied electrical parameters. Particularly, ECT is an effective local therapy that uses electroporation to enhance the cytotoxic effect of bleomycin or cisplatin injected intravenously or intratumorally. Pre-clinical investigations to test alternative anti-cancer drugs, explore new combinations of treatment modalities, and evaluate different sets of pulse protocols for effective tissue electroporation, are ongoing. Further ECT developments include the treatment of deep-seated tumors with percutaneous, laparoscopy, and endoscopy approaches, with the aim of establishing a less invasive approach. ECT is highly effective in the treatment of tumors of ...

Treatment of early and multiple cutaneous unresectable recurrences is a major therapeutic problem with around 80% of patients relapsing within 5 years. For lesions refractory to elective treatments, electrochemotherapy (ECT) involving electroporation combined with antineoplastic drug treatment appears to be a new potential option. This study was undertaken to analyze the short- and long-term responses of lesions treated with ECT with intravenous injection of bleomycin in melanoma patients with in-transit disease or distant cutaneous metastases. Between June 2007 and September 2012, 60 patients with relapsed and refractory cutaneous melanoma metastases or in-transit disease underwent 100 courses of ECT with intravenous injection of bleomycin. Response to treatment was evaluated three months after ECT. A long-lasting response was defined as no cutaneous or in-transit relapse after a minimum of six months. Three months after ECT, a complete response was observed in 29 patients (48.4%), a partial response

Electrochemotherapy is a new treatment used to treat recurrent melanoma. It combines chemotherapy with a small electrical current.

European network for development of electroporation-based technologies and treatments. This COST Action aims at fostering development of new and existing electroporation-based applications and as well as facilitating coordination and interdisciplinary exchange of knowledge and know-how between researchers from different scientific fields and countries. Action results will provide scientific and technological progress in the field of medicine, biotechnology and environment preservation.

Breast cancer is the most common cancer in women worldwide. The World Health Organization [1], reported that cancer is a leading cause of death [2] and that breast cancer is the second most common cause of cancer death in women, with a 521000 deaths in 2012. Typical treatments are based on surgical procedure (lumpectomy or mastectomy), often the surgical removal is combined with radiation therapy, chemotherapy or hormone therapy as an adjuvant therapy [3]. The invasiveness of the surgical technique has lead to an interest in new types of minimally invasive treatments such as radiofrequency ablation, cryosurgery and irreversible electroporation [4-9].. In these last years, electrochemotherapy (ECT) has been evaluated as a new possible technique to treat different kind of tumors [10-13].. Electrochemotherapy (ECT) is a technique that combines chemotherapy (insertion of non permeant or low permeant chemotherapeutic drugs with high cytotoxicity) with local application of pulsed electric fields to ...

Enhanced local electric fields are predominant in nonlinear optical properties, particularly in surface-enhanced Raman scattering (SERS), which is a sensitive technique used for the detection of trace amounts of chemicals. Analysis of the electric fields around nanostructures indicates that they can provide a basic foundation to obtain greater SERS intensity. Professor ZHANG Zhongyue and his group from the College of Physics and Information Technology at Shaanxi Normal University have proposed a novel scheme to enhance the local electric fields around nanostructures. The scheme is based on manipulation of the incident wave to allow the superposition of the electric fields of multiple beams of light to work as the excitation source for the electrons in the nanostructures, and larger electric fields are thus excited around the nanostructures. Their work, entitled Enhancing the electric fields around the nanorods by using metal grooves, was published in SCIENCE CHINA Physics, Mechanics & ...

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Radiologic findings after EP/ECT of large hepatic vessels and hepatic parenchyma were characterized in a porcine model, which was selected due to anatomical and physiological similarities with the human liver.1, 33 The results showed decreased perfusion in the treated area. This finding was an anticipated result since EP/ECT induces a local blood flow modifying effect or vascular lock characterized by the vasoconstriction and increased wall permeabilization of small blood vessels. The effect on perfusion is shorter in EP compared to that in ECT and shorter in healthy compared to tumor tissue, which is known as the vascular disrupting effect. Chemotherapeutic drugs are cytotoxic to endothelial cells, especially neoplastic endothelial cells, and this effect prolongs decreased perfusion.34, 35, 36, 37, 38, 39, 40, 41 In our case, there was no difference between EP and ECT, and no vascular disrupting effect was observed in healthy hepatic parenchyma28, which confirms that bleomycin at the doses ...

The results of our study indicate that intra-abdominal surgery involving ECT of colorectal liver metastases was associated with only minor and clinically irrelevant changes in functioning of the heart detected in early post-operative care and as such presented no life threat for the patients. No major changes in functioning of the heart such as rhythm changes (i.e., increased induction of abnormal heartbeats, ventricular tachycardia or fibrillation) or pathological morphological changes (e.g., ST segment changes) that would suggest myocardial ischemia were found in ECG signals.. According to the literature, surgery and anesthesia produce a stress response characterized by increased sympathetic and hormonal activity which may predispose the patient to arrhythmias [30]. Post-operative arrhythmias are thus quite common and affect about 7% of patients that underwent major non-cardiothoracic surgery. Post-operative arrhythmias occur more commonly in older patients, most often in the first four days ...

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C.F. e P.I. 01021130362 - Capitale Sociale € 206.000,00 i.v. - REA 205183 - Reg. Soc. Trib. 14968 - Iscritto nelle imprese di ...

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...

We developed a MATLAB-based toolbox, COMETS (COMputation of Electric field due to Transcranial current Stimulation), for simulating local electric fields generated by tDCS. Since COMETS has a simple and interactive graphical user interface, users can readily simulate various electrode configurations, sizes, and orientations without coding any MATLAB scripts. COMETS evaluates 3D cortical current distributions based on the electrostatic finite element method (FEM). ...

Double-blinded phase II clinical study. We will compare the effect of calcium electroporation for the treatment of cutaneous metastases with standard treatment: electrochemotherapy with intratumoral injection of bleomycin. Separate randomisation will be performed and the lesions will be treated with either intratumoral injection of calcium or bleomycin. It is a once only treatment and the patients will be followed up for 6 months.. It is a non-inferiority study and we accept a difference in response on 15%. ...

The procedure involves giving chemotherapy into the tumour or sometimes directly into a vein (intravenously). Short, powerful pulses of electricity are then directed to the tumour using electrodes.. The electrical pulses allow the medicine to enter the tumour cells more effectively and cause more damage to the tumour. The procedure is usually carried out using general anaesthetic, where youre unconscious, but some people may be able to have local anaesthetic, where youre conscious but the area is numbed.. Depending on how many tumours need to be treated, the procedure can take up to an hour to complete. The main side effect is pain where the electrode was used, which can last for a few days and may require painkillers.. It takes around six weeks for results to appear and the procedure usually needs to be repeated.. Your specialist can give you more detailed information about electrochemotherapy. You can also read the 2013 National Institute for Health and Care Excellence (NICE) guidance about ...

The procedure involves giving chemotherapy into the tumour or sometimes directly into a vein (intravenously). Short, powerful pulses of electricity are then directed to the tumour using electrodes.. The electrical pulses allow the medicine to enter the tumour cells more effectively and cause more damage to the tumour. The procedure is usually carried out using general anaesthetic, where youre unconscious, but some people may be able to have local anaesthetic, where youre conscious but the area is numbed.. Depending on how many tumours need to be treated, the procedure can take up to an hour to complete. The main side effect is pain where the electrode was used, which can last for a few days and may require painkillers.. It takes around six weeks for results to appear and the procedure usually needs to be repeated.. Your specialist can give you more detailed information about electrochemotherapy. You can also read the 2013 National Institute for Health and Care Excellence (NICE) guidance about ...

The procedure involves giving chemotherapy into the tumour or sometimes directly into a vein (intravenously). Short, powerful pulses of electricity are then directed to the tumour using electrodes.. The electrical pulses allow the medicine to enter the tumour cells more effectively and cause more damage to the tumour. The procedure is usually carried out using general anaesthetic, where youre unconscious, but some people may be able to have local anaesthetic, where youre conscious but the area is numbed.. Depending on how many tumours need to be treated, the procedure can take up to an hour to complete. The main side effect is pain where the electrode was used, which can last for a few days and may require painkillers.. It takes around six weeks for results to appear and the procedure usually needs to be repeated.. Your specialist can give you more detailed information about electrochemotherapy. You can also read the 2013 National Institute for Health and Care Excellence (NICE) guidance about ...

The procedure involves giving chemotherapy into the tumour or sometimes directly into a vein (intravenously). Short, powerful pulses of electricity are then directed to the tumour using electrodes.. The electrical pulses allow the medicine to enter the tumour cells more effectively and cause more damage to the tumour. The procedure is usually carried out using general anaesthetic, where youre unconscious, but some people may be able to have local anaesthetic, where youre conscious but the area is numbed.. Depending on how many tumours need to be treated, the procedure can take up to an hour to complete. The main side effect is pain where the electrode was used, which can last for a few days and may require painkillers.. It takes around six weeks for results to appear and the procedure usually needs to be repeated.. Your specialist can give you more detailed information about electrochemotherapy. You can also read the 2013 National Institute for Health and Care Excellence (NICE) guidance about ...

These formulas of calculation are there only to confirm the calculations made by the veterinarian of his side. They can not in any way replace the calculations made by the veterinarian himself during the preparation of the act of electrochemotherapy ...

Kaposis sarcoma (KS) is a multifocal neoplasm of lymphatic endothelium-derived cells infected with human herpesvirus 8. Four clinical subtypes are distinguished: the classic, the endemic, the epidemic subtype in HIV positive patients and the iatrogenic subtype. The diagnosis is primarily based on clinical features and confirmation by histology with immunohistochemistry. Cutaneous distribution and severity, mucosal, nodal and visceral involvement depend on the type of KS with in general indolent behaviour and chronic evolution in the classic subtype and the more severe forms in iatrogenic or epidemic subtypes. Management should aim at achieving disease control. For localised lesions, several local therapies have been developed without randomised trial comparisons. Radiotherapy, intralesional chemotherapies and electrochemotherapy have high response rates. Topical treatments-imiquimod or topical 9-cis-retinoid acid-can also be used. Systemic treatments are reserved for locally aggressive extensive and

GHENO, S. M.; PAULIN F., P. I. and MORELLI, M. R.. Potential barrier behavior in BiCuVOX materials. Cerâmica [online]. 2011, vol.57, n.344, pp.428-430. ISSN 0366-6913. http://dx.doi.org/10.1590/S0366-69132011000400009.. The BiMeVOX materials appear being high attractive for applications at low temperatures when the ionic conductivity is the determining parameter. The occurrence of many types substitution was confirmed for numerous Me ions, but the greatest interest have been focused on the BiCuVOX materials. The objective of this study was to image the potential barriers in BiCuVOX. The sample was sintered for 4 h at 750 °C and the results show that the high density compound can be obtained. Simultaneously, topography and electric force microscopy (EFM) images are viewed side-by-side. EFM experiments were performed and the results show the maps of the electric field distribution on the surface of BiCuVOX. The formation of potential barrier was observed and the width and intensity were ...

3D Modelling & Kĩ thuật Projects for $30 - $250. Im looking for a freelancer capable to improve two 3D models using COMSOL, to define the potential and electric field distribution between two solids. The challenge of this project is to mesh microns...

This paper presents the operation of an Electrical Demand-Side Management (EDSM) system in a real solar house. The use of EDSM is one of the most important action lines to improve the grid electrical efficiency. The combination between the EDSM and the PV generation performs a new control level in the local electric behavior and allows new energy possibilities. The solar house used as test-bed for ...

Utility Connect is your FREE source in Morongo valley California to shop local Electric, Cable, Satellite TV, Internet, Home Security, Phone, City Water and Gas providers. Setup all of your utilities in one place. Find the best packages & bundles in your area.

TY - JOUR. T1 - Quantitative Determination of Contribution by Enhanced Local Electric Field, Antenna-Amplified Light Scattering, and Surface Energy Transfer to the Performance of Plasmonic Organic Solar Cells. AU - Liu, Shenghua. AU - Hou, Yidong. AU - Xie, Wei. AU - Schlücker, Sebastian. AU - Yan, Feng. AU - Lei, Dang Yuan. PY - 2018/7/26. Y1 - 2018/7/26. N2 - Plasmonic metal nanostructures are widely used as subwavelength light concentrators to enhance light harvesting of organic solar cells through two photophysical effects, including enhanced local electric field (ELEF) and antenna-amplified light scattering (AALS), while their adverse quenching effect from surface energy transfer (SET) should be suppressed. In this work, a comprehensive study to unambiguously distinguish and quantitatively determine the specific influence and contribution of each effect on the overall performance of organic solar cells incorporated with [email protected] core-shell nanoparticles (NPs) is presented. By investigating ...

Bleomycin is a treatment for a number of types of cancer. Bleomycin is a type of antibiotic that is poisonous to cells. It binds to the cancer cells DNA so that the cells cant divide or grow. Electrochemotherapy is a cancer treatment. The definition of therapeutic window of lectrochemotherapy is based on the observed responses of the tumors that were treated at different time points after the drug injection. To refine the method, thorough knowledge is needed about the pharmacokinetics and pharmacodynamics of bleomycin, which would base on sensitive analytical method. This method was not available until recently. The aim of the study is therefore to determine pharmacokinetics and pharmacodynamics of bleomycin in patients treated with electrochemotherapy, for optimization of the treatment ...

Electroporation as a delivery method is increasingly important in gene therapy, not only in vivo but also in in vitro experimental systems. Different applications of gene electrotransfer require high viability of cells and high transfection efficiency of gene electrotransfer. It was already demonstrated that the addition of fetal bovine serum (FBS) immediately after gene electrotransfer leads to improved cell survival and transfection efficiency. Therefore, the aim of the study was to determine whether prolonged incubation of cells in FBS, for more than standard 5 min, can lead to increased transfection efficiency and improved cell survival. Different murine melanoma and murine and human endothelial cell lines were transfected with plasmid encoding green fluorescent protein and then incubated for different periods of time in FBS (5-30 min). Transfection efficiency was determined by flow cytometry and fluorescence microscopy and cell survival by cell viability assay. Prolonged incubation of cells ...

Molecular medicine through gene therapy is challenged to achieve targeted action. This is now possible utilizing bionic electrode arrays for focal delivery of naked (plasmid) DNA via gene electrotransfer. Here, we establish the properties of array-based electroporation affecting targeted gene delivery. An array with eight 300 μm platinum ring electrodes configured as a cochlear implant bionic interface was used to transduce HEK293 cell monolayers with a plasmid-DNA green fluorescent protein (GFP) reporter gene construct. Electroporation parameters were pulse intensity, number, duration, separation and electrode configuration. The latter determined the shape of the electric fields, which were mapped using a voltage probe. Electrode array-based electroporation was found to require ~100 × lower applied voltages for cell transduction than conventional electroporation. This was found to be due to compression of the field lines orthogonal to the array. A circular area of GFP-positive cells was created when

Garcia-Sanchez T, Mercadal B, Polrot M, Muscat A, Sarnago H, Lucía Ó, Mir LM. Successful tumor Electrochemotherapy using Sine Waves. IEEE Transactions on Biomedical Engineering. 2019 ;(Early access)(1):1-1. ...

European network for development of electroporation-based technologies and treatments. This COST Action aims at fostering development of new and existing electroporation-based applications and as well as facilitating coordination and interdisciplinary exchange of knowledge and know-how between researchers from different scientific fields and countries. Action results will provide scientific and technological progress in the field of medicine, biotechnology and environment preservation.

A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.

To report on the first short-term oncologic outcomes of percutaneous irreversible electroporation for small renal masses.Patients with cT1a renal masses treated with irreversible electroporation from April 2013 through December 2016 were reviewed.

Irreversible electroporation is a minimally invasive technique for the non-thermal destruction of cells in a targeted volume of tissue, using brief electric pulses, (~100 µs long) delivered through electrodes placed into or around the targeted region. These electric pulses destabilize the integrity of the cell membrane, resulting in the creation of nanoscale defects that increase a cells permeability to exchange with its environment. When the energy of the pulses is high enough, the cell cannot recover from these effects and dies in a non-thermal manner that does not damage neighboring structures, including the extracellular matrix. IRE has been shown to spare the major vasculature, myelin sheaths, and other supporting tissues, permitting its use in proximity to these vital structures. This technique has been proposed to be harnessed as an advantageous non-thermal focal ablation technique for diseased tissues, including tumors. IRE electric pulses may be delivered through small (ø ≈ 1 mm) ...

PurposeNumerical simulations are used for treatment planning in clinical applications of irreversible electroporation (IRE) to determine ablation size and shape. To assess the reliability of simulations for treatment planning, we compared simulation results with empiric outcomes of renal IRE using computed tomography (CT) and histology in an animal model.MethodsThe ablation size and shape for six different IRE parameter sets (70-90 pulses, 2,000-2,700 V, 70-100 µs) for monopolar and bipolar electrodes was simulated using a numerical model. Employing these treatment parameters, 35 CT-guided IRE ablations were created in both kidneys of six pigs and followed up with CT immediately and after 24 h. Histopathology was analyzed from postablation day 1.ResultsAblation zones on CT measured 81 ± 18 % (day 0, p ≤ 0.05) and 115 ± 18 % (day 1, p ≤ 0.09) of the simulated size for monopolar electrodes, and 190 ± 33 % (day 0, p ≤ 0.001) and 234 ± 12 % (day 1, p ≤ 0.0001) for bipolar electrodes. ...

Ablation Technologies Market by Product (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, Microwave), Application (General & Cosmetic Surgery, Cardiovascular, Cancer, Ophthalmology, Orthopedics) - Global Forecasts to 2019 - Market research report and industry analysis - 8399979

Read Intracranial Nonthermal Irreversible Electroporation: InVivo Analysis, The Journal of Membrane Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Irreversible electroporation (IRE), a new tissue ablation procedure available since 2007, could meet the requirements for ideal focal therapy of …

Nanoknife - irreversible electroporation blijkt succesvolle operatietechniek te zijn bij lokaal uitgezaaide alvleesklierkanker. Slechts 6 patiënten (3%) kreeg recidief op 2,5 jaar meting. Mediane overleving nu al 24.9 maanden (range 4.9-85 maanden). Artikel update 8 mei 2019

IRE was used to treat 48 tumors in 47 patients. 22/48 tumors (45.8%) were biopsy-confirmed renal cell carcinoma (RCC). No complications ≥ Clavien Grade III occurred and 36 patients (76.6%) were discharged the same day. Initial treatment success rate was 91.7% (n=44/48); 3 treatment failures were managed with salvage radiofrequency ablation and 1 with robotic partial nephrectomy. Median follow up was 50.4-months (IQR 29.0-65.5). The 5-year local recurrence-free survival was 81.4% in biopsy-confirmed RCC patients and 81.0% in all patients. 5-year metastasis-free survival was 93.3% and 97.1%, respectively, and 5-year overall survival was 92.3% and 90.6%, respectively. 5-year cancer-specific survival was 100% for both biopsy-confirmed RCC and all patient groups ...

A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region.

TY - JOUR. T1 - Cutaneous metastasis from primary gastric cancer. T2 - A case report and review of the literature. AU - Cesaretti, Manuela. AU - Malerba, Michele. AU - Basso, Valeria. AU - Boccardo, Chiara. AU - Santoni, Roberta. AU - DAlessandro, Gabriele. AU - Weiss, Andrea. AU - Campisi, Corrado. AU - De Cian, Franco. PY - 2014. Y1 - 2014. N2 - Cutaneous metastases of internal neoplasms are uncommon. They can be metachronous or synchronous to the primary tumor and typically appear late in the course of advanced malignant disease. Gastric cancer rarely is reported as a cause of cutaneous metastasis; the most common metastatic sites are the liver, peritoneal cavity, and lymph nodes. We report a case of cutaneous metastasis from a primary gastric tumor that had been treated 6 years prior. There was no visceral invasion. The patient was treated successfully via a relaparotomy to exclude any macroscopic abdominal recurrence and complete excision of the lesion with a plastic flap to compensate for ...

PET scans of lung tumor near airway before (left) and 3 months after (right) irreversible electroporation treatment (credit: Constantinos Sofocleous, Memorial

Serša, I.; Bajd, F.; Kranjc, M.; Busse, H.; Garnov, N.; Trampel, R.; Miklavčič, D.: Comparison of single-shot rapid acquisition with relaxation enhancement and echo planar current density MRI sequences for monitoring of electric pulse delivery in irreversible electroporation. In: 1st World congress on electroporation and pulsed electric fields in biology, medicine and food & environmental technologies, pp. 83 - 86 (Eds. Jarm, T.; Kramar, P.). Springer, Singapore (2016 ...

High-frequency irreversible electroporation is a nonthermal method of tissue ablation that uses bursts of 0.5- to 2.0-microsecond bipolar electric pulses to permeabilize cell membranes and induce cell death. High-frequency ...

CRT defibrillators receive additional? end lifesaving therapy to quickly an unusually rapid, life-threatening heart rhythm CRT and CRT-D is increasingly important therapeutic option for patients with moderate and severe heart failure since Medtronic began clinical evaluation of of its CRT systems in 1997.. About CRTIn CRT, a stopwatch? sized device chest chest and is connected by lines to the left and right ventricles of the heart. Electrical pulses, the device synchronizes heart beats, which pumps blood through the body better.. courtesy of you, the entire Kaiser Daily Health Policy view Report, search the archives, or sign up for email delivery at Kaiser Daily Health Policy Report Reprint for imperial network. A free service of The Henry J. Released. Kaiser Family Foundation. 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.The technique of, as irreversible electroporation are known was headed by a research team headed by Boris Rubinsky, currently on leave a ...

eng] Despite the discovery of novel inhibitors of tumor angiogenesis, protein-based antiangiogenic cancer therapy suffers some limitations that antiangiogenic gene therapy could overcome. We investigated the effect on tumor growth and metastasis of three antiangiogenic plasmids administered by two intratumoral electrotransfers. Plasmids encoding recombinant disintegrin domain of ADAM-15 (RDD), thrombospondin 1 (TSP-1) and the soluble isoform of the VEGF receptor 1 (sFlt-1) were injected into B16F10 melanoma-bearing C57BL/6 mice followed by electroporation. Tumor volume was measured daily using a digital caliper. Metastasis was monitored by in vivo bioluminescence after surgical removal of the primary luciferase-encoding tumor 5 days after intratumoral electrotransfer. Markers of vascularization and cell proliferation were quantified by immunohistochemistry. All the plasmids induced a significant inhibition of tumor growth, doubling of mean survival time and long term survivors (~40% vs 0% in ...

Methods and apparatus are provided for treatment of heart arrhythmia via renal neuromodulation. Such neuromodulation may effectuate irreversible electroporation or electrofusion, ablation, necrosis a

To investigate the reliability of simulations for planning pancreatic irreversible electroporation (IRE) ablations compared with computed tomography (CT) and pathology outcomes in an animal model. Simulations were performed varying treatment parameters, including field strength (1.5-2.5 kV/cm), p...

Results of theoretical and experimental investigations, devoted to the analysis and optimization of optoelectronic image formation devices (IFD) on the basis of deformable polymer films (DPF) at the expense of choice of the polymer material rheology, electric field distribution in DPF by means of electrode raster and heat deformation regime is presented. For DPF structure investigations the tunnel electron microscopy technique has been used ...

Roots Analysis has announced the addition of Non-Viral Transfection Reagents and Systems Market, 2020-2030 report to its list of offerings.. Over time, innovative approaches surrounding the development of potential therapies using non-viral transfection systems have prompted several companies to commercialize proprietary technologies to facilitate gene transfer into cells, via a variety of physical, chemical and other non-viral methods. The growing demand for safe and effective genetically engineered ATMPs is likely to further propel the opportunity for non-viral transfection system developers.. To order this 220+ page report, which features 100+ figures and 125+ tables, please visit the website. Key Market Insights. More than 110 companies claim to offer different types of non-viral transfection systems. The majority of players engaged in the development and commercialization of non-viral transfection systems offer reagents (52%), followed by companies offering electroporation-based ...

We utilize the Volume Integral Equation Formulation (VIEF) and the method of moments to calculate the electromagnetic scattering and absorption of aerosol particles with branched-chain structures. Two kinds of polarization of the incident electromagnetic wave were considered: the cross- and end-fire polarizations. The numerical results of internal electric field distribution, absorbed power, and extinction and scattering cross sections, obtained from the VIEF, show excellent agreement with the Mie theory for the special case of spherical particles. Comparison between the results of the VIEF and Iterative Extended Boundary Condition Method for very long oriented (elongated) chains of particles also showed good agreement. After validating the accuracy of the VIEF, the absorption characteristics of three branched-chain structures simulated from microscopic pictures of coagulated smoke aerosol particles were calculated. Results showed that the ratio of absorption in the two polarization cases, ...

An electrosurgical instrument includes a conductive element in the form of a needle that is surrounded by an insulation layer except at a conductor tip portion of the conductive element. The conductor tip portion and insulation layer each have unique geometric shapes and composition of the parts to reduce or eliminate the production of smoke and eschar and reduce tissue damage. The electrosurgical needle electrode is configured to concentrate the flow of electrosurgical at the tip region.

The aims of this study were: (i) to develop mathematical models of electric and related thermal phenomena in tissue exposed to electric pulses that are used for in vivo electropermeabilization and gene electrotransfer, and (ii) to analyze the possibility that voltage and current measurement during pulse delivery can be used to actively monitor and predict the extent of tissue electropermeabilization. The proposed models are based on the solution of appropriate partial differential equations for electric potential and temperature distribution in tissue using finite-element method (3D FEM). For two configurations of electrodes (parallel plates and two needles) and different pulse delivery protocols, including short high-voltage permeabilizing pulses and long low-voltage electrophoretic pulses, we performed numerous simulations in order to quantify the influence of tissue electrical conductivity (including anisotropy, nonlinearity and temperature dependence), pulse parameters (amplitude, number, ...

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Cutaneous metastases from colorectal cancer are extremely rare and generally appear several years after diagnosis or resection of the primary tumor. Although this phenomenon is uncommon, it is very important and often indicates a poor prognosis. We present a case of a 76-year-old female patient with multiple cutaneous metastatic nodules on the back, just 1 month after resection of rectal cancer. Unfortunately, the patient gave up the follow-up treatment due to her age and poor physical condition; she died 3 months later. In view of its rarity of occurrence and lack of experience in treatment, we reviewed the literature and report as follows. ...

Question - What causes feeeling of electrical pulses through neck and shoulders?. Ask a Doctor about when and why MRI is advised, Ask an Orthopaedic Surgeon

Spanggaard I., Snoj M., Cavalcanti A., Bouquet C., Sersa G., Robert C., Cemazar M., Dam E., Vasseur B., Attali P., Mir L.M., Gehl J. Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: safety and efficacy results of a phase I first-in-man study. Human Gene Ther Clin Developme, 2013; 24: 99-107.[PubMed: 23980876 ...

Features:Comfortable massageIncludes 8 massage modes 4 massage padsLarge, oval electrode pads for gentle massage2 output channels-A & B can be used to

With 16 kinds of strength. Power supply: 2 x AAA dry cell (Not included) Can use 7 hours continuously. Package included. 1 x Neck Massager Machine. 2 x Massager Pads. 1 x Wire. 1 x English User Manual. No Retail Box. Note:. 1.Please allow 1-3mm differs due to manual measurement.. 2.Due to the different display and different light,the picture may not reflect the actual color of the item.. Thanks for your understanding.. ...

Because this product contains batteries, it can only be shipped via select shipping methods. These shipping methods are displayed when you check out the order ...

Because this product contains batteries, it can only be shipped via select shipping methods. These shipping methods are displayed when you check out the order ...

Minneapolis is negotiating agreements with local electric and natural gas utilities that seek more commitment to clean energy, a year after controversial debates over the city starting its own municipal utility.. City leaders are renewing 20-year-old franchise agreements, set to expire in December, that give Xcel Energy and CenterPoint Energy access to public right of way in exchange for millions of dollars in fees. The new arrangements are expected to be much shorter in duration, accompanied by a separate partnership that would have utilities work with the city to meet its greenhouse gas reduction targets.. Negotiations could be completed as early as in September, though utility and city officials have declined to offer many details.. Council Member Cam Gordon said he expects that the results will fall in line with an environmental consultants recommendations in February. Given the restrictions state laws put on what cities can require in franchise agreements, the report advised Minneapolis to ...

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Using an asymptotic analysis, we analytically calculate the dispersion and the field distribution of guided modes in an all-dielectric coaxial fiber. We compare the analytical results with those obtained from numerical calculations and find excellent agreement between them. We demonstrate that both the Bragg reflection and the total internal reflection play important roles in providing confinement and determining the dispersion characteristics of the coaxial fiber modes.. © 2002 Optical Society of America. Full Article , PDF Article ...

Electrocompetent cells work using the electroporation process. Electrical pulses created pores that allows genetic material to permeate the bacterial membrane. Invitrogen offers a variety of electrocompetent E. coli cells to reliably clone your DNA with high efficiency. The convenient packaging formats and a variety of electroporation cuvettes will fulfill all of your electrocompetent cell transformation requirements.

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Turn on the elctro-porator and test it: 30V, 25ms, 2 pulses and see if u can see small bubbles (you should…). If you dont see them check your connection and see if there is a big bubble stuck in the bottom electrode ...

The ECM / VIP 3000 Electroporation Monitoring Systems combine advanced monitoring capabilities with traditional BTX Electroporation Generators.