PubMedID: 27452611 | Diagnosis of pre-eclampsia and assessment of severity through examination of the placenta with acoustic radiation force impulse elastography. | International journal of gynaecology and obstetrics : the official organ of the International Federation of Gynaecology and Obstetrics | 10/1/2016
Also, the research study gives a complete list of all the leading players working in the United States Transient Elastography Devices market. Moreover, the financial status, company profiles, business strategies and policies, and the latest expansions in the United States Transient Elastography Devices market have been mentioned in the research study.. For more inquiry before purchase: https://www.researchnreports.com/enquiry_before_buying.php?id=61553. Table of Contents 1 Industry Overview of Transient Elastography Devices. 2 Manufacturing Cost Structure Analysis of Transient Elastography Devices. 3 Technical Data and Manufacturing Plants Analysis of Transient Elastography Devices. 4 United States Transient Elastography Devices Overall Market Overview. 5 Transient Elastography Devices Regional Market Analysis. 6 United States 2011-2016E Transient Elastography Devices Segment Market Analysis (by Type). 7 United States 2011-2016E Transient Elastography Devices Segment Market Analysis (by ...
Urinary bladder fibrosis (thickening and scarring) is fairly uncommon in children. Traditionally, the presence of urinary bladder fibrosis has been confirmed directly with bladder biopsy or using urodynamic testing.. We will use ultrasound ARFI (acoustic radiation force impulse)-derived shear wave velocities to potentially identify the presence of urinary bladder wall fibrosis. We hypothesize that shear wave velocities found within the bladder wall will increase with increasing evidence of fibrosis. ...
Quantitative Shear Wave Velocity Measurement on Acoustic Radiation Force Impulse Elastography for Differential Diagnosis between Benign and Malignant Thyroid Nodules: A Meta-analysis. Liu BJ, Li DD, Xu HX, Guo LH, Zhang YF, Xu JM, Liu C, Liu LN, Li XL, Xu XH, Qu S, Xing M. Ultrasound Med Biol. 2015 Sep 11 ...
Acoustic radiation force impulse (ARFI) scanning uses a swept focus in transmit. Using a changing delay or phase profile across the array during the generation of the ARFI pulse, a time varying focus
A method for reliable, noninvasive estimation of Abdominal Aortic Aneurysms (AAA) wall mechanics may be a useful clinical tool for rupture prediction. An in vitro AAA model was developed from an excised porcine aorta, with elastase treatment. The AAA model behaviour was analysed using Acoustic Radiation Force Impulse (ARFI) imaging techniques to generate displacements in both aneurysmal and normal aortic tissue. The incremental modulus of the arteries was indicative of early collagen recruitment, typical in aneurysms due to elastin degradation. Opening angle measurement showed a four fold decrease from healthy aorta to AAA model. The mechanical changes that occur during aneurysm formation were found to be detectable using ARFI imaging ...
Accepted Manuscript. Abstract Background and Aims. Non-invasive predictors identifying subjects with compensated liver disease at highest risk for transitioning to a decompensated state are lacking. We hypothesized that liver shear stiffness as measured by magnetic resonance elastography is an important non-invasive predictor of hepatic decompensation.. Methods. Among patients with advanced fibrosis undergoing magnetic resonance elastography (2007-11), a baseline cohort and follow up cohort (compensated liver disease) were established. Cause specific cox proportional hazards analysis adjusting for competing risks was utilized to determine the association between elevated liver shear stiffness and development of decompensation (hepatic encephalopathy, ascites, variceal bleeding).. Results. In the baseline cohort (n=430), subjects with decompensated liver disease had a significantly higher mean liver shear stiffness (6.8 kPa, IQR 4.9-8.5) as compared to subjects with compensated liver disease (5.2 ...
TY - JOUR. T1 - Magnetic resonance elastography of skeletal muscle. AU - Alex Dresner, M.. AU - Rose, Gregory H.. AU - Rossman, Phillip J.. AU - Muthupillai, Raja. AU - Manduca, Armando. AU - Ehman, Richard L.. PY - 2001/2/3. Y1 - 2001/2/3. N2 - While the contractile properties of skeletal muscle have been studied extensively, relatively little is known about the elastic properties of muscle in vivo. Magnetic resonance elastography (MRE) is a phase contrast-based method for observing shear waves propagating in a material to determine its stiffness. In this work, MHE is applied to skeletal muscle under load to quantify the change in stiffness with loading. A mathematical model of muscle is developed that predicts a linear relationship between shear stiffness and muscle load. The MRE technique was applied to bovine muscle specimens (N = 10) and human biceps brachii in vivo (N = 5). Muscle stiffness increased linearly for both passive tension (14.5 ± 1.77 kPa/kg) and active tension, in which the ...
TY - JOUR. T1 - Sonographic elastography combined with conventional sonography. T2 - How much is it helpful for diagnostic performance?. AU - Sohn, Yu Mee. AU - Kim, Min Jung. AU - Kim, Eun Kyung. AU - Kwak, Jin Young. AU - Moon, Hee Jung. AU - Kim, Soo Jin. PY - 2009/4/1. Y1 - 2009/4/1. N2 - Objective. The purpose of this study was to evaluate the diagnostic performance of conventional sonography combined with sonographic elastography for differentiation between benign and malignant breast lesions and to assess the diagnostic performance with two types of interpretation criteria for sonographic elastography. Methods. For this study, we included 281 lesions from 267 patients that were diagnosed as benign or malignant by sonographically guided biopsy and prospectively analyzed by conventional sonography and sonographic elastography from October to December 2007. The histopathologic results from sonographically guided biopsy were used as a reference standard. The final assessments were made ...
TY - JOUR. T1 - Prediction of esophageal varices in patients with cirrhosis. T2 - Usefulness of three-dimensional MR elastography with echo-planar imaging technique. AU - Shin, Sung Ui. AU - Lee, Jeong Min. AU - Yu, Mi Hye. AU - Yoon, Jeong Hee. AU - Han, Joon Koo. AU - Choi, Byung Ihn. AU - Glaser, Kevin J.. AU - Ehman, Richard Lorne. PY - 2014. Y1 - 2014. N2 - Purpose: To determine the diagnostic performance of magnetic resonance (MR) elastography in comparison to spleen length and dynamic contrast material-enhanced (DCE) MR imaging in association with esophageal varices in patients with liver cirrhosis by using endoscopy as the reference standard. Materials and Methods: This retrospective study received institutional review board approval, and informed consent was waived. One hundred thirty-nine patients with liver cirrhosis who underwent liver DCE MR imaging, including MR elastography, were included. Hepatic stiffness (HS) and spleen stiffness (SS) values assessed with MR elastography, as ...
AbstractThe analysis was aimed to evaluate the diagnostic accuracy of shear wave elastography (SWE) for malignant breast lesions through a meta-analysis.Related articles were searched from Pubmed, Embase, and Cochrane library. Overall sensitivity and specificity were analyzed with DerSimonian and La
Food intake increases liver stiffness, but it is believed that liver stiffness returns to baseline two hours after a meal. The aim of this study was to investigate the impact of different sized meals on liver stiffness. Liver and spleen stiffness was measured with transient elastography (TE) and real-time 2-dimensional shear wave elastography (2D-SWE). Patients ingested a 625 kcal and a 1250 kcal liquid meal on two consecutive days. We measured liver and spleen elasticity, Controlled attenuation parameter (CAP) and portal flow at baseline and after 20, 40, 60, 120 and 180 minutes. Sixty patients participated, 83% with alcoholic liver disease. Twenty-eight patients had METAVIR fibrosis score F0-3 and 32 patients had cirrhosis. Liver stiffness, spleen stiffness and CAP increased after both meals for all stages of fibrosis. False positive 2D-SWE liver stiffness measurements caused 36% and 52% of patients with F0-3 fibrosis to be misclassified with higher stages of fibrosis after the moderate and high
Experimental study of applying shear wave elastography for examining effects of high intensity focused ultrasound ablation against subcutaneously implanted VX2 tumors in rabbits, F
Ultrasound elastographic methods have provided the means for the objective and noninvasive evaluation of the stiffness of organs, such as the liver, breast, and thyroid. For example, liver ultrasound elastography provides information regarding the stage of fibrosis and can help physicians manage patients.1. We herein report our experience using ultrasound elastography to evaluate keloids. The device used in this study was a HITACHI Hivision Avius ultrasound scanner with real-time strain elastography and the L74M linear (5-13 MHz) probe (Hitachi Medical Corporation, Tokyo, Japan). This device calculates the tissue deformation or strain induced by a stress that is applied with slight free hand compression. The extent of the strain of the tissue is related to its stiffness, that is, the value decreases as the tissue becomes harder. The strain elastography provides a qualitative measurement of stiffness that is expressed as the ratio to a control region, such as the normal dermis.. A 53-year-old man ...
HIV positive patients who have liver dysfunction have shown to be correlated with high mortality and morbidity. To date, ARFI elastography has been known to correlate with the degree of liver fibrosis in chronic liver disease. However, ARFI velocity has not yet been reported in HIV patients. The aim of this study was to identify the normal range of ARFI velocity and liver stiffness value by recruiting HIV patients without abnormal liver function and chronic liver disease ...
Purpose: The aim of the study was to compare three different elastography methods, namely Strain Elastography (SE), Point Shear-Wave Elastography (pSWE) using Acoustic Radiation Force Impulse (ARFI)-Imaging and 2D-Shear Wave Elastography (2D-SWE), in the same study population for the differentiation of thyroid nodules. Materials and methods: All patients received a conventional ultrasound scan, SE and 2D-SWE, and all patients except for two received ARFI-Imaging. Cytology/histology of thyroid nodules was used as a reference method. SE measures the relative stiffness within the region of interest (ROI) using the surrounding tissue as reference tissue. ARFI mechanically excites the tissue at the ROI using acoustic pulses to generate localized tissue displacements. 2D-SWE measures tissue elasticity using the velocity of many shear waves as they propagate through the tissue. Results: 84 nodules (73 benign and 11 malignant) in 62 patients were analyzed. Sensitivity, specificity and NPV of SE were ...
By John Gever, Deputy Managing Editor, MedPage Today Published: April 26, 2013. Reviewed by F. Perry Wilson, MD, MSCE; Instructor of Medicine, Perelman School of Medicine at the University of Pennsylvania. AMSTERDAM -- Although biopsy remains the gold standard for diagnosing liver fibrosis, imaging tests increasingly appear to be a viable way to garner equivalent information with less patient discomfort and risk, researchers said here.. In presentations at the meeting of the European Association for the Study of the Liver, scientists from across Europe reported on the strengths and weaknesses of various imaging modalities as tools for routine clinical practice.. There was no clear winner among transient elastography, magnetic resonance elastography (MRE), real-time shear wave elastography (RTSWE), and acoustic radiation force impulse (ARFI) imaging, but all appeared to be nearly as accurate as liver biopsy in quantitative assessment of fibrosis and for predicting outcomes such as death and ...
Background: Transient elastography (FibroScan) is a new, non-invasive, rapid, and reproducible method allowing evaluation of liver fibrosis by measurement of liver stiffness. In cirrhotic patients, liver stiffness measurements range from 12.5 to 75.5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease.. Methods: A total of 711 patients with chronic liver disease were studied. Aetiologies of chronic liver diseases were hepatitis C virus or hepatitis B virus infection, alcohol, non-alcoholic steatohepatitis, other, or a combination of the above aetiologies. Liver fibrosis was evaluated according to the METAVIR score.. Results: Stiffness was significantly correlated with fibrosis stage (r = 0.73, p,0.0001). Areas under the receiver operating characteristic curve (95% confidence interval) were 0.80 (0.75-0.84) for patients ...
TY - JOUR. T1 - Ultrasound tissue displacement imaging with application to breast cancer. AU - Chen, E. J.. AU - Adler, R. S.. AU - Carson, P. L.. AU - Jenkins, William Kenneth. AU - OBrien, W. D.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - A method for quantitative imaging of internal tissue motion based on speckle tracking is described. Tissue displacement images from eight patients with sonographically apparent breast masses are used to illustrate the technique. The local displacement response of tissues surrounding malignant and benign breast masses is compared, testing the hypothesis that altered mechanical properties may result in motion signatures for many soft tissue tumors relative to their host tissue. In addition, the potential or anticipated influence of various biological and physical factors on tissue motion response is discussed.. AB - A method for quantitative imaging of internal tissue motion based on speckle tracking is described. Tissue displacement images from eight patients with ...
Magnetic resonance elastography (MRE) is a potentially transformative imaging modality allowing local and non-invasive measurement of biological tissue mechanical properties. It uses a specific phase contrast MR pulse sequence to measure induced vibratory motion in soft material, from which material properties can be estimated. Compared to other imaging techniques, MRE is able to detect tissue pathology at early stages by quantifying the changes in tissue stiffness associated with diseases. In an effort to develop the technique and improve its capabilities, two inversion algorithms were written to evaluate viscoelastic properties from the measured displacements fields. The first one was based on a direct algebraic inversion of the differential equation of motion, which decouples under certain simplifying assumptions, and featured a spatio-temporal multi-directional filter. The second one relies on a finite element discretization of the governing equations to perform a direct inversion. Several
Liver stiffness, measured by transient elastography (FibroScan), reflects not only fibrosis of the liver but also intrahepatic inflammation and portal hypertension. The diagnostic performance of FibroScan depends on the care and quality of the procedures used to measure liver stiffness. An experienced physician must interpret the liver stiffness measurement as a function of the clinical situation and other imaging and test results. Liver stiffness is strongly correlated with fibrosis of the liver during hepatitis, with co-infection by HCV (hepatitis C virus) and HIV (human immunodeficiency virus), with recurrence of HCV infection after liver transplantation, and with chronic cholestatic diseases. Liver stiffness is strongly correlated with the severity of portal hypertension and of cirrhosis. ...
0048] FIG. 3 shows a schematic block diagram of the ultrasound elastography system 10. As already laid out above, the ultrasound elastography system 10 comprises an ultrasound image acquisition probe (PR) 14, the ultrasound signal and image processing assembly (CU) 16, the display (DI) 18 and the input device (ID) 20. As further laid out above, the probe (PR) 14 comprises a transducer array 26, for example a phased two-dimensional transducer array or automatically scanned one-dimensional transducer array. Further, the probe comprises a part 27 of the tracking device, for example a coil that generates an electromagnetic field that is sensed via the sensors 25, 25 or a fiducial, in particular to support optical tracking. In general, the ultrasound signal and image processing assembly (CU) 16 may comprise a central processing unit that may include analog and/or digital electronic circuits, a processor, microprocessor or the like to coordinate the whole image acquisition and provision. Further, the ...
Using a 3.03 m/s cutoff value, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of SWVmax for differentiating benign and malignant CLNs were 93%, 59%, 68%, 91%, and 75%, respectively. B-mode and Doppler had a sensitivity, specificity, PPV, NPV, and accuracy of 79.2%, 71.2%, 71.6%, 78.7%, and 75%, respectively. B-mode, Doppler, and VTIQ SWE combined had 87.5%, 75%, 76.3%, 86.6%, and 81% for the same parameters, respectively ...
Although magnetic resonance elastography MRE has been used to estimate isotropic stiffness in the heart, myocardium is known to have anisotropic properties. This study investigated the determinability of global transversely isotropic material parameters using MRE and finiteelement modeling FEM. A FEMbased material parameter identification method,...
To evaluate the gastrocnemius/soleus and biceps brachii muscle stiffness by Acoustic Radiation Force Impulse (ARFI) elastography in the hemiplegia patients, sixty patients with hemiplegia after stroke were recruited. Baseline data were collected including age, gender, body mass index, education level, dominant side, affected side, time since stroke, stroke etiology. All patients were evaluated with before treatment and posttreatment with Broonstroom staging, Modified Ashworth spasticity scale, and Functional Independence Measures scale. The patient was divided into 3 groups: 1) Neuromuscular electrical stimulation group, 2) Rehabilitation group, 3) Neurumusculer electrical stimulation + Rehabilitation group. Affected and unaffected side biceps and gastrocnemius, ARFI elastography measurements were used to measure thickness and elastic values. In addition, before and after treatment, length and thickness were measured from all patients. Of the 60 subjects, 28 were female (46.7%) and 32 (53.3%
Liver stiffness measurement (LSM) can assess liver fibrosis in patients with chronic hepatitis B (CHB). We evaluated whether LSM can be used to assess changes in liver fibrosis during antiviral treatm
Repeated liver stiffness measurements (LSM) in the first year following liver transplant (LT) could discriminate between slow and rapid fibrosers
The aim of this study was to assess the diagnostic value of acoustic radiation force impulse (ARFI) imaging for differentiating superficial lymph nodes.Virtual touch tissue imaging (VTI) grade and shear wave velocity (SWV) were analyzed and compared in 97 patients (65 women, 32 men; mean age, 49 y; range, 23-72 y) with 97 lymph nodes [23 chronic nonspecific reactive lymph nodes (CLNs), 38 metastatic lymph nodes (MLNs), and 36 blood and lymphatic system diseases lymph nodes (BLLNs)]. The elastography characteristics in patients with CLNs, MLNs, and BLLNs were compared using the nonparametric Kruskal-Wallis test and Mann-Whitney U test for continuous variables and categorical variables ...
Liver stiffness (LS) assessed using transient elastography (TE) was recently demonstrated to be a reliable and accurate noninvasive tool for assessing the degree of liver fibrosis [8,9]. Recent large-scale longitudinal studies also showed a significant association between LS value and the risk of development of hepatocellular carcinoma (HCC) or cirrhotic complication in patients with chronic hepatitis B (CHB) [10,11]. Theoretically, TE also reflects a progressive rise in portal pressure due to increased hepatic vascular resistance related to hepatic fibrosis. Accumulating evidence suggests that TE adequately reflects the findings of HVPG, indicating that it is a useful modality for evaluating PH and cirrhotic complications [12-18]. TE has good performance for discriminating between patients with and without CSPH (area under the receiver operating characteristic curve [AUROC] 0.82-0.94) [19]. In addition, a TE value,13 kPa reliably excludes CSPH, while values ,21 kPa have an accuracy equal to ...
March 12, 2008 - Siemens will showcase its latest ultrasound technologies, focusing on its ACUSON S2000, ACUSON X300 and the laptop-based ACUSON P50 echocardiography system, at the American Institute of Ultrasound in Medicine (AIUM), March 12-15, in San Diego, CA.. The companys new premier general imaging platform, the ACUSON S2000 includes paradigm-shifting strain imaging and quantification capabilities, Virtual Touch tissue imaging and Virtual Touch tissue quantification, uses acoustic energy to displace tissue for a qualitative and quantitative assessment of deep tissue stiffness. The new ACUSON X300 ultrasound system applies to both general imaging and cardiovascular applications in one package. The system includes capabilities for cardiac assessment, such as syngo Velocity Vector Imaging (VVI) technology for detailed assessment of myocardial mechanics, and syngo Auto Left Heart that uses progressive pattern recognition to measure ejection fraction and volumes of the left ventricle and ...
Disclosed is a method and system that efficiently compares data from two ultrasound images and derives a tissue displacement map for real-time diagnostic imaging applications.
It is well known that prostate cancer (PCa) has a higher cell density than the surrounding normal tissue. This increased cell density leads to an alteration in tissue elasticity, which can be measured
Objective To evaluate the applicability, reproducibility, and diagnostic performance of a new 2D-shear wave elastography (SWE) using the comb-push technique (2D CP-SWE) for detection of hepatic fibrosis, using histopathology as the reference standard. Materials and methods This prospective study was approved by the institutional review board, and informed consent was obtained from all patients. The liver stiffness (LS) measurements were obtained from 140 patients, using the new 2D-SWE, which uses comb-push excitation to produce shear waves and a time-aligned sequential tracking method to detect shear wave signals. The applicability rate of 2D CP-SWE was estimated, and factors associated with its applicability were identified. Intraobserver reproducibility was evaluated in the 105 patients with histopathologic diagnosis, and interobserver reproducibility was assessed in 20 patients. Diagnostic performance of the 2D CP-SWE for hepatic fibrosis was evaluated by receiver operating characteristic (ROC)
Supersonic shear imaging (SSI)[8][9] gives a quantitative, real-time two-dimensional map of tissue stiffness. SSI is based on SWEI: it uses acoustic radiation force to induce a push inside the tissue of interest generating shear waves and the tissues stiffness is computed from how fast the resulting shear wave travels through the tissue. Local tissue velocity maps are obtained with a conventional speckle tracking technique and provide a full movie of the shear wave propagation through the tissue. There are two principal innovations implemented in SSI. First, by using many near-simultaneous pushes, SSI creates a source of shear waves which is moved through the medium at a supersonic speed. Second, the generated shear wave is visualized by using ultrafast imaging technique. Using inversion algorithms, the shear elasticity of medium is mapped quantitatively from the wave propagation movie. SSI is the first ultrasonic imaging technology able to reach more than 10,000 frames per second of deep ...
The recent letter by Jansen et al 1 presenting an algorithm to rule out clinically significant portal hypertension (CSPH) by combining shear-wave elastography of liver (L-SWE) and spleen (S-SWE) is an important contribution to the increasing knowledge regarding non-invasive assessment of patients with compensated advanced chronic liver disease (cACLD). Baveno VI recommendations focused on transient elastography as a tool to rule in CSPH in patients with the authors cACLD of viral etiology,2 ,3 but there is no doubt that other related elastography techniques should work similarly. Also, recent UK guidelines on variceal bleeding introduced elastography for variceal screening and diagnosis.4 In their study, the authors concluded that combining L-SWE ,16 kPa with S-SWE ,26.6 kPa showed a very high sensitivity (98.6%), with a remarkable negative predictive value for CSPH (96.3%). However, we have a few comments about the design and interpretation of results that we hope may enhance the ...
FibroScan transient elastography is a painless, quick, noninvasive diagnostic technique used to measure liver scarring, or fibrosis.
Purpose: : The application of force to the cornea has long been used for measurement of intraocular pressure and more recently to probe the elastic properties of the cornea itself. Current modalities exert force onto the anterior surface of the cornea. Our aim was to ascertain if acoustic radiation force, which would be absorbed across the full corneal thickness, could be safely used to generate corneal surface displacements. Methods: : We tested two configurations. In the first, we used a dual-element probe having a central 40 MHz element and an outer 20 MHz ring, both with a common focus. The second probe was a single-element focused 35 MHz transducer. We used an arbitrary waveform generator in combination with a broadband power amplifier to produce tonebursts to excite the radiation-force emitting element (which in the first configuration was the 20 MHz ring only). We measured the radiation force produced at a series of voltages and determined the maximum duration of the toneburst for each ...
The speaker discusses advances in liver elastography. Elastography techniques, Elastography basics, P-SWE, 2D -SWE, Elastography values, How to perform an examination, Factors affecting ARFI pulse, Variables that will affect SWE, m/s vs kPa, How many measurements?, Interpretation, Conclusions.
The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several dis...
Background It is estimated that up to 5% of inflammatory bowel disease (IBD) patients have clinically significant liver disease due to multifactorial causes such as underlying Primary Sclerosing Cholangitis, pharmacotherapy, fatty liver disease or nodular regenerative hyperplasia. In recent years, transient elastography (TE), which uses the sonic detection of liver stiffness to predict hepatic fibrosis has increasingly replaced the need for a liver biopsy. It has been validated in patients with chronic hepatitis C as an accurate non-invasive predictor of advance fi brosis and cirrhosis. Aims Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defi ned by an increased liver stiffness measurement (LSM) using Transient Elastography (FibroScan®). Methods 110 random IBD patients and 55 non-IBD control patients (composed of patient relatives and hospital staff) had their LSM recorded. The median reading in kilopascals (kPa) of 10 successful acquisitions ...
Objective: Tissue elasticity has been used in medicine as an indication of tissue anomalies for centuries. Palpation of breast and prostate are still the most common clinical procedures in cancer screening for those corresponding anatomical structures. Elastography is an emerging technique for imaging tissue viscoelasticity. This project aims to address some of the pending issues in generating ultrasound elastography images, while also investigating novel acquisition and analysis techniques for advanced imaging applications.. Elastography is an emerging technique for imaging tissue viscoelasticity from internal tissue displacements observed often in magnetic resonance or ultrasound time sequences. Elastography based on ultrasound is particularly important, as ultrasound is real-time, cost-effective, non-ionizing, and thus a widely-used imaging modality. Elastography has great potential in diagnosis and treatment planning because pathologies, e.g. tumors and cirrhosis, are often stiffer than ...
Hydrocephalus occurs due to a blockage in the transmission of cerebrospinal fluid (CSF) in either the ventricles or subarachnoid space. Characteristics of this condition include increased intracranial pressure, which can result in neurologic deterioration [1]. Magnetic resonance elastography (MRE) is an imaging technique that estimates the mechanical properties of tissue in vivo. While some investigations of brain tissue have been performed using MRE [2,3,4,5], the effects due to changes in interstitial pressure and fluid content on the mechanical properties of the brain remain unknown. The purpose of this work is to assess the potential of MRE to differentiate between the reconstructed properties of normal and hydrocephalic brains. MRE data was acquired in 18 female feline subjects, 12 of which received kaolin injections resulting in an acute form of hydrocephalus. In each animal, four MRE scans were performed during the process including one pre-injection and three post-injection scans. The ...
This study clearly demonstrated that LS was significantly increased after the Fontan procedure and that CVP was a predictor of LS. MRE is a highly sensitive tool that can evaluate liver fibrosis in children who undergo the Fontan procedure and enable earlier detection of LS than biomarkers.
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ALVAREZ, Daniel et al. Usefulness of transient elastography (Fibroscan®) in the assessment of fibrosis in patients with chronic liver disease. Medicina (B. Aires) [online]. 2012, vol.72, n.1, pp. 10-14. ISSN 0025-7680.. The prognosis and management of chronic liver disease largely depends on the extent and progression of liver fibrosis. Unfortunately, liver biopsy, an invasive and painful technique with several limitations, continues to be the gold standard for the staging and grading of fibrosis. Therefore, accurate noninvasive tests for liver injury are urgently needed. During the last years, transient elastography (Fibroscan®) has been proposed for the assessment of hepatic fibrosis in patients with chronic liver disease, by measuring liver stiffness. The aim of this study was to evaluate the effectiveness, objectivity and safety of this technique. We included 68 patients who underwent a liver biopsy in the last 18 months with a wide spectrum of chronic liver diseases. All procedures as ...
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RESULTS:On LB 13 (6.6%) patients had F0, 32 (16.2%) had F1, 52 (26.4%) had F2, 47 (23.9%) had F3, and 53 (26.9%) had F4. A direct, strong correlation was found between TE measurements and fibrosis (r = 0.741), between ARFI and fibrosis (r = 0.730) and also between TE and ARFI (r = 0.675). For predicting significant fibrosis (F>_ 2), for a cut-off of 6.7 kPa, TE had 77.5% sensitivity (Se) and 86.5% specificity (Sp) [area under the receiver operating characteristic curve (AUROC) 0.87] and for a cut-off of 1.2 m/s, ARFI had 76.9% Se and 86.7% Sp (AUROC 0.84). For predicting cirrhosis (F = 4), for a cut-off of 12.2 kPa, TE had 96.2% Se and 89.6% Sp (AUROC 0.97) and for a cut-off of 1.8 m/s, ARFI had 90.4% Se and 85.6% Sp (AUROC 0.91). When both elastographic methods were taken into consideration, for predicting significant fibrosis (F >_ 2), (TE >_6.7 kPa and ARFI >_1.2 m/s) we obtained 60.5% Se, 93.3% Sp, 96.8% positive predictive value (PPV), 41.4% negative predictive value (NPV) and 68% accuracy, ...
MONDAY, Oct. 17, 2016 (HealthDay News) - For patients with chronic hepatitis B (CHB), liver stiffness measurement (LSM) is associated with hepatic events and death, while metabolic syndrome increases the risk of cardiovascular events, according to a study published online Oct. 1 in Hepatology.. Jenny Yeuk-Ki Cheng, from the Chinese University of Hong Kong, and colleagues recruited 1,466 CHB patients for LSM with transient elastography and detailed metabolic profiling. Patients were followed for any clinical event.. The researchers found that 93 and 44 patients developed hepatic and cardiovascular events, respectively, at a mean follow-up of 88 ± 20 months; 70 patients died. The cumulative probability of hepatic events was higher for patients with baseline LSM ,8.0 kPa versus ≤8.0 kPa at eight years (12.3 versus 3.1 percent; P , 0.001). The cumulative probability of cardiovascular events was higher for patients with metabolic syndrome (8.0 versus 2.1 percent; P , 0.001). High LSM had no impact ...
Ultrasound based techniques and transient elastography may not be precise methods for the detection of esophageal varices in liver cirrhosis