Ectromelia virus E3L protein: is a dsRNA-binding proein with a conserved C-terminal dsRNA-binding domain; amino acid sequence in first source
Of course, there are plenty of differences, too. For example, ectromelia is usually fatal during the liver stage, while for Plasmodium the liver is merely a
Relatively benign viruses can be converted into highly virulent viruses via the introduction of genes of interest. For example, Ectromelia virus, a natural pathogen of mice that causes mousepox, recently was recombined with interleukin-4 as part of an effort to develop a live virus immuno-contraceptive vaccine. Surprisingly, the recombined virus caused 60% mortality in 2 strains of mice, whereas the wild type virus caused no death [1]. A credible bioterrorism scenario might entail the release of such a recombined or chimeric virus tailored for maximum infectivity and pathogenicity but not readily detectable using our current "state-of-the-art" diagnostics (i.e., PCR and micro-array chips.) Accordingly, there is a need for methods that can identify unknown viral pathogens and which can reveal extensive genomic information. Such methods would not only prove useful for our defense against bioterrorism, but also would improve our capacities to identify and control outbreaks of naturally occurring ...
Rats were immunized with C57BL/10 mouse spleen cells enriched for T lymphocytes. Spleen cells were fused with NS-1 myeloma cells. The antibody reacts with an antigen, CD45, present on mouse lymph node and spleen cells but not on brain, kidney, liver or red blood cells. It antibody reacts with all isoforms of CD45. The CD45 antigen is common to all lines of leukocyte differentiation. Tested and found negative for ectromelia virus (mousepox).
TY - JOUR. T1 - Involvement of H 2L gene products in virus immune T cell recognition. Evidence for an H 2L restricted T cell response. AU - Biddison, W. E.. AU - Hansen, T. H.. AU - Levy, Robert B. AU - Doherty, P. C.. PY - 1978/12/1. Y1 - 1978/12/1. N2 - The H-2L locus is closely linked to H-2D and codes for antigenic specificities present on a 45,000 mol wt glycoprotein that is distinct from the molecule which bears the D region private specificity. It was found that BALB/c-H-2(db) mice, which lack detectable cell-surface H-2L gene products, were able to generate influenza- and vaccinia-immune cytotoxic T cells which lyse D region-compatible target cells, although they have been reported to be incapable of making a similar response to ectromelia virus (7). Thus, the lack of H-2L antigenic specificities does not produce a general loss of responsiveness for other viruses even when a highly cross-reactive pox virus (vaccinia) was studied. Antisera-blocking experiments utilizing sera specific for ...
Note: I am an adult continuous learner. I started to learn EVM at work; however, I am hitting a wall with the EVM problems I am posting. Since I am a visual learner and learn by example, I need the following completed. 1) Provide and show all answers and step by step work to obtain the answer, not skipping any steps. Show a ...
In 2001, the New Scientist (4) published an article on a deadly virus created accidentally by an Australian research team trying to genetically engineer a contraceptive vaccine for mice."They spliced a gene for the protein interleukin-4 (IL-4) into the relatively harmless mousepox virus (ectromelia virus) in the hope that IL-4 would boost the immune system to make more antibodies. When the researchers injected this vaccine into mice, all the mice died. In fact, this synthetic virus was so lethal that it also killed half of all the mice that had been vaccinated against mousepox.The work published in the Journal of Virology (http://jvi.asm.org/content/75/3/1205.long) revealed that hte mice used were genetically resistant to the mousepox viruis in the first place. Genetic resistance to mousepox varies among inbred laboratory mice, and depends on natural killer (NK) cells and cytotoxic T-lymphocytes (CTL) responses to viral infection, both of which destroy cells that have been infected with virus so ...
In 2001, the New Scientist (4) published an article on a deadly virus created accidentally by an Australian research team trying to genetically engineer a contraceptive vaccine for mice."They spliced a gene for the protein interleukin-4 (IL-4) into the relatively harmless mousepox virus (ectromelia virus) in the hope that IL-4 would boost the immune system to make more antibodies. When the researchers injected this vaccine into mice, all the mice died. In fact, this synthetic virus was so lethal that it also killed half of all the mice that had been vaccinated against mousepox.The work published in the Journal of Virology (http://jvi.asm.org/content/75/3/1205.long) revealed that hte mice used were genetically resistant to the mousepox viruis in the first place. Genetic resistance to mousepox varies among inbred laboratory mice, and depends on natural killer (NK) cells and cytotoxic T-lymphocytes (CTL) responses to viral infection, both of which destroy cells that have been infected with virus so ...
Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia ...
Expression of murine soluble CD30 attenuates mousepox development.Groups of 15 susceptible BALB/c mice were infected intranasally with 100 pfu each of the indic
In recent years our understanding of the role of NK cells in the response to viral infection has grown rapidly. Not only do we realize viruses have many immune evasion strategies to escape NK cell responses, but that stimulation of NK cell subsets during an antiviral response occurs through receptors seemingly geared directly at viral products and that NK cells can provide a memory response to viral pathogens. Tremendous knowledge has been gained in this area through the study of Herpes viruses, but appreciation for the significance of NK cells in the response to other types of viral infections is growing. The function of NK cells in defense against poxviruses has emerged over several decades beginning with the early seminal studies showing the role of NK cells and the NK gene complex in susceptibility of mouse strains to Ectromelia, a poxvirus pathogen of mice. More recently, greater understanding has emerged of the molecular details of the response. Given that human diseases caused by poxviruses
The accidental creation of a smallpox-related virus that kills mice by wiping out part of the immune system leaves us one step away from the ultimate bioweapon
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Australian scientists have accidentally created a virus that kills mice by crippling their immune systems, and warn that the technique might threaten to produce deadlier forms of human viruses and new kinds of biological weapons. Mice infected with the pathogen died, even many of those who had been vaccinated against mousepox. Because people have the same immune system gene, a similar step could in theory create a pathogen deadly to people.
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The poxvirus infection is caused by a DNA virus from the Poxviridae virus family, specifically from the Orthopoxvirus genus. This is a relatively common transmitted virus, but it can be readily inactivated by several types of viral disinfectants.
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If you configure a Red Hat CloudForms appliance to act as a dedicated database instance when you configure the database, you can enable the EVM server and user interface on that appliance via the following procedure - If you have already configured a region on the appliance and other appliances connect to that region, use the Join Region in External Database option to enable the EVM server. Enter localhost as the database host name. If you have not already configured a region on the appliance, use the Create Region in External Database option to enable the EVM server. Enter localhost as the database host name ...
Moscow State University ranks 50th on The Times most recent ranking of 100 best international universities; no other Russian university is included. Technology & innovation
A billboard in Moscow is equating President Obama with lung cancer. In tactics reminiscent of the Cold War, a bus stop ad in the Russian capital features a...
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After battling MS for 34 years with no effective treatment in sight, Amanda Weyman-Jones is looking to Russia for a treatment which could give her life back.
It has been an amazing experience and one we are so happy to be included in. Before coming to Russia a lot of people were a little negative about what they expected our experience would be but Astrakham is truly beautiful, the people we have met have been nothing but supportive and loving towards us. The other models are very much star struck with Madeline and have made her feel very special. ...
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Via Scoop.it - Virology NewsInvestments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials. These broad-based efforts have also resulted in the identification of new inhibitors of orthopoxvirus replication that target…
The city of Moscow, Russia possesses a large population of homeless canines. Many operate in packs and have become accustomed to begging. Its small minority who frequent or inhabit the subway have attracted international attention for learning how to use the trains to commute between various locations. The issues of Moscows feral dogs was first mentioned by Russian writers such as journalist Vladimir Gilyarovsky in the late 19th century. Their sad lot was dramatised by Anton Chekhov in the famous short story Kashtanka, by Mikhail Bulgakov in the novella Heart of a Dog, and by Gavriil Troyepolsky in the novel White Bim Black Ear. As of March 2010, there were an estimated 35,000 homeless dogs living within Moscows city limits, or approximately one dog for every 300 people, and about 32 per square km (84 per square mile). According to Andrei Poyarkov of the A.N. Severtsov Institute of Ecology and Evolution, a biologist and wolf expert who has studied Moscows feral dogs for over 30 years, the ...
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The city portal, informing about the points where you can get the vaccine, as well as about the features of the vaccines, needs to be created in Moscow, said Alexei Venediktov, deputy chairman of the Public Chamber of Moscow
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Moscow [http://www.moscowchamber.com] is a city in Idaho with a population of around 22,000 people, an agricultural center and the home of the University of Idaho. The surrounding area is generally referred to as the Moscow-Pullman area -- Pullman is a city in Washington, that is fairly symbiotic with Moscow. They are 8 miles apart.
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A Moscow kindergarten has reportedly been fired at intermittently over a two week period by an unknown man, after an attacker wounded a 10-year-old boy in the stomach with a pneumatic gun on May 9.
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