... , Authors: Roderick AF MacLeod, Stefan Nagel. Published in: Atlas Genet Cytogenet Oncol Haematol.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
miR-145 inhibits cell proliferation through E2F3 dependent cell cycle regulation(A) qRT-PCR were performed to determine the expression level of E2F3 after tra
Plasmid pGL3-Control-E2F-3UTR-WT from Dr. Joshua Mendells lab contains the insert E2F transcription factor 1 and is published in Nature. 2005 Jun 9. 435(7043):839-43. This plasmid is available through Addgene.
Nov 14 11:24 356511 km ++ F- 2h 2016 Mar 8 8:36 356529 km ++ F- 1h 1993 Jan 19 22:13 356548 km ++ F+ 0h 1992 Dec 12 21:38 356567 km ++ F+ 4h 2008 Mar 19 19:10 356577 km ++ F+ 0h 2011 Jan 30 9:04 356592 km ++ F+ 2h 2010 Nov 4 0:42 356614 km ++ F- 4h 1998 Dec 22 11:01 356654 km ++ F- 6h 2001 Dec 22 11:01 356654 km ++ F- 6h 1999 Oct 26 11:52 356754 km ++ F+ 6h 2007 Feb 7 22:20 356852 km ++ F- 8h 2002 Sep 28 1:47 356876 km ++ F- 1h 2015 Aug 10 17:44 356896 km ++ F- 0h 2014 Apr 25 17:18 356925 km ++ F- 2h 1994 Jul 30 7:37 356948 km ++ F- 2h 1996 May 6 3:34 356953 km ++ F- 0h 2012 Sep 16 15:25 356965 km + F- 3h 1997 Jun 23 11:11 356989 km ++ F- 0h 2013 Jun 13 1:06 357006 km + F- 2h 1995 Apr 17 4:59 357157 km + F+ 9h 2003 Jul 21 19:46 357159 km F+ 8h 2005 Sep 8 3:08 357174 km + F+ 8h 2006 Jun 3 13:11 357248 km ++ F+ 8h 2004 Jan 10 10:53 357500 km + F- 16h 2009 Dec 22 9:29 358353 km F+ 23h 1991 Nov 14 22:59 366050 km F+3d 1h 2000 ...
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Mat Sterner, a 2011 SU chemistry graduate has been working with NeverWet, LLC since graduation. NeverWet functions as a Research and Development company for all things water-repellent and has been an industry leader for the past ten years in developing superhydrophobic products for paint, coating, and textile applications. Their major manufacturing partner is Rustoleum, but they are an independent company that has also developed water repellent solutions for several other customers. Their website is NeverWet.com and can be found on YouTube and other major social networks. Products include multi-surface superhydrophobic (andsuperoleophobic) systems, a water-shedding treatment for glass surfaces, and fabric treatments for boots/shoes as well as indoor and outdoor fabrics. Mats work with a few other people in a small lab in an industrial park outside Leola, PA. The office is built into a warehouse operated by a metal working company. It makes for a close-knit environment where everyone gets along ...
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E2F8 antibody [N3C3] (E2F transcription factor 8) for WB. Anti-E2F8 pAb (GTX112299) is tested in Human samples. 100% Ab-Assurance.
هدف: هدف از این مطالعه تجربی بررسی تأثیر هورمون‌های تخمدانی بر بیان ژن‌های دخیل در لانه گزینی در سلول‌های استرومایی آندومتر انسان در محیط کشت بود. مواد و روش‌ها: پس از تأیید نرمالیتی بافت‌های آندومتر حاصل از هیسترسکوپی با رنگ‌آمیزی هماتوکسیلین و ائوزین، سلول‌های آندومتر به کمک کلاژناز تیپ 1 جداسازی و از فیلترهایی به ابعاد 100 و 40 میکرومتر عبور داده شدند. سلول‌های استرومایی حاصل در محیط DMEM/F-12 تا پاساژ 4 کشت شد و سپس به‌مدت 7 روز در دو بخش مطالعه شد: گروه کنترل (بدون هورمون) و گروه‌های آزمون با غلظت‌های متفاوت استروژن (E2)؛ 3/0، 7/0 و 1 نانومول بر لیتر و غلظت ثابت
The Medicinal chemistry course deals with the drug discovery, design and development. Attention is paid to the description of the mechanism of action of drugs, to interactions of drugs with their molecular targets (e.g. enzymes and receptors), and to the study of physico-chemical properties of compounds. The relationship between biological properties (activity) of the compounds and their chemical structure (structure-activity relationship (SAR) study) is discussed as well. During the course, common classes of drugs (e.g. antibiotics, antivirals, anticancer agents) and the basics of pharmacodynamics (what the drug does to the body) and pharmacokinetics (what the body does to the drug), including ADMET (absorption, distribution, metabolism, excretion, toxicity) are also discussed. An excursion to IOCB (medicinal chemistry, virology, biochemical pharmacology) will also be part of the course ...
After two days of sales, GURPS Characters had sold 91 copies via e23. After a similar time, also through e23, GURPS Campaigns had only sold 77 . . .
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Complete information for E2F5 gene (Protein Coding), E2F Transcription Factor 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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The transcription factor DRTF1/E2F is implicated in the control of cellular proliferation due to its interaction with key regulators of cell cycle progression, such as the retinoblastoma tumour suppressor gene product and related pocket proteins, cyclins and cyclin-dependent kinases. DRTF1/E2F DNA binding activity arises when a member of two distinct ... read more families of proteins, DP and E2F, interact as DP/E2F heterodimers. Here, we report the isolation and characterisation of a new member of the E2F family of proteins, called E2F-5. E2F-5 was isolated through a yeast two hybrid assay in which a 14.5 d.p.c. mouse embryo library was screened for molecules capable of binding to murine DP-1, but also interacts with all known members of the DP family of proteins. E2F-5 exists as a physiological heterodimer with DP-1 in the generic DRTF1/E2F DNA binding activity present in mammalian cell extracts, an interaction which results in co-operative DNA binding activity and transcriptional activation ...
Cancer is a disease state that arises as a result of multiple alterations in signaling pathways that are critical for making key cell fate decisions in normal cells. Understanding how these pathways operate under normal circumstances, therefore, is crucial for comprehensive understanding of tumorigenic process. With Myc and E2F pathways being central components for controlling cell proliferation, an important property that defines a cancer cell, as well as expanding roles for microRNAs(miRNA) in control of gene expression, we asked if we may better understand the underlying regulatory (transcription factor, microRNA) structure that contribute to Myc and E2F pathway activities. Through integrative analysis of mRNA and miRNA expression profile, we observe a distinct regulatory pattern in which, in the case of Myc pathway, Myc-induced miRNAs were contributing to the repression of negative regulators of cell cycle, including PTEN, while in case of E2F pathway, E2F-induced miRs were forming an ...
Objective: To investigate the effects and mechanisms of secreted protein, acidic and rich in cysteine (SPARC) on high fluoride-induced apoptosis of thyrocytes. Methods: Human thyroid cells (Nthy-ori 3-1) were cultured and treated with various concentrations (0.1, 1 and 10 mmol/L) of NaF for 24 h, and the expression of SPARC was evaluated using Real-time PCR and Western blot, respectively. The cells were divided into four groups: control group, NaF group, si-SPARC group (cells were transfected with SPARC siRNA for 48 h and then exposed to NaF for 24 h), and si-NC group (cells were transfected with negative control siRNA for 48 h and then exposed to NaF for 24 h). Cytotoxicity was assayed using CCK-8 and LDH; cell apoptosis rate was detected with ELISA. The expressions of cleaved caspase3 (c-caspase3) and IGF-1R were measured by Western blot. In addition, si-SPARC and si-IGF-1R were co-transfected into thyrocytes to further explore mechanisms of SAPRC by evaluating apoptosis. Results: The mRNA and ...
Military aviation forum mainly focusing on the F-16, F-35 and F-22 jet fighters. Contains high quality discussions and has a gentle but strict moderation.
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E2F is a complex family of transcription factors implicated in different cell fates, including proliferation and apoptosis (Stevens and La Thangue, 2003; Frolov and Dyson, 2004; Polager and Ginsberg, 2008; van den Heuvel and Dyson, 2008). The first family member identified, E2F‐1, physically interacts with the retinoblastoma tumour suppressor protein pRb, which negatively regulates E2F‐1 activity (Bandara and La Thangue, 1991; Zamanian and La Thangue, 1992; Weinberg, 1995; Stevens and La Thangue, 2003; Frolov and Dyson, 2004). While it has been established that E2F‐1 promotes proliferation and therefore is potentially oncogenic, it has also become clear that E2F‐1 is endowed with apoptotic activity (Polager and Ginsberg, 2008; van den Heuvel and Dyson, 2008). Thus, many E2F target genes are connected with apoptosis (Ren et al, 2002), and in Rb−/− mice the enhanced level of tissue‐specific apoptosis reflects deregulated E2F‐1 activity (Tsai et al, 1998; Iaquinta and Lees, 2007). ...
Necdin兔多克隆抗体(ab18554)可与小鼠, 大鼠, 人样本反应并经WB, ChIP实验严格验证,被5篇文献引用。所有产品均提供质保服务,中国75%以上现货。
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