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TY - JOUR. T1 - Biological advantages of porous hydroxyapatite scaffold made by solid freeform fabrication for bone tissue regeneration. AU - Kwon, Byeong Ju. AU - Kim, Jungsung. AU - Kim, Yong Hwa. AU - Lee, Mi Hee. AU - Baek, Hyun Sook. AU - Lee, Dae Hyung. AU - Kim, Hye Lee. AU - Seo, Hyok Jin. AU - Lee, Min Hyeon. AU - Kwon, Soon Young. AU - Koo, Min Ah. AU - Park, Jong Chul. PY - 2013/7/1. Y1 - 2013/7/1. N2 - Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of ...
Macroporous hydroxyapatite scaffolds for bone tissue engineering applications: Physicochemical characterization and assessment of rat bone marrow stromal cells ...
TY - JOUR. T1 - Preparation, characterization and in vitro test of composites poly-lactic acid/hydroxyapatite scaffolds for bone tissue engineering. AU - Carfi Pavia, Francesco. AU - Ghersi, Giulio. AU - Brucato, Valerio Maria Bartolo. AU - Conoscenti, Gioacchino. AU - La Carrubba, Vincenzo. AU - Greco, Silvia. PY - 2018. Y1 - 2018. N2 - In this work, the possibility to produce composite Poly-L-lactic acid (PLLA)/Hydroxyapatite (HA) porous scaffolds via Thermally Induced Phase Separation (TIPS) for bone tissue engineering applications was investigated. Several PLLA/HA wt/wt ratios (95/5, 90/10, 70/30, 50/50, 34/66) were tested and the as-obtained scaffolds were characterized via Scanning Electron Microscopy, Wide Angle X-Ray Diffraction, Thermogravimetric analysis, Gas Pycnometry, Differential Scanning Calorimetry and mechanical compression test. Morphological analysis revealed an open structure with interconnected pores and HA particles embedded in the polymer matrix. Finally, cell cultures ...
Polymer ceramic composites obtained as the result of a mineralization process hold great promise for the future of tissue engineering. Simulated body fluids (SBFs) are widely used for the mineralization of polymer scaffolds. In this work an exhaustive study with the aim of optimizing the mineralization process on a poly(L-lactic acid) (PLLA) macroporous scaffold has been performed. We observed that when an air plasma treatment is applied to the PLLA scaffold its hydroxyapatite nucleation ability is considerably improved. However, plasma treatment only allows apatite deposition on the surface of the scaffold but not in its interior. When a 5 wt % of synthetic hydroxyapatite (HAp) nanoparticles is mixed with PLLA a more abundant biomimetic hydroxyapatite layer grows inside the scaffold in SBF. The morphology, amount, and composition of the generated biomimetic hydroxyapatite layer on the pores surface have been analyzed. Large mineralization times are harmful to pure PLLA as it rapidly degrades ...
Free Online Library: The effects of C[O.sub.2] laser with or without nanohydroxyapatite paste in the occlusion of dentinal tubules.(Research Article, Report) by The Scientific World Journal; Biological sciences Environmental issues Carbon dioxide lasers Health aspects Hydroxyapatites Oral surgery Methods
BISAC: SCI000000. Hydroxyapatite is the most widely accepted biomaterial for the repair and reconstruction of bone tissue defects. It has all the characteristic features of biomaterials, such as, biocompatible, bioactive, osteoconductive, non-toxic, non-inflammatory and non-immunogenic properties. In this book, the authors present current research in the study of the synthesis, properties and applications of hydroxyapatites. Topics discussed include nanodimensional and nanocrystalline hydroxyapatite and other calcium orthophosphates; application of biomimetic nanocrystalline apatites in drug delivery and tissue engineering; polymer matrix mediated synthesis of nano hydroxyapatite crystals; osteointegration of titanium porous implants with carbon nanocoating and hydroxyapatite particles into the pores; hydroxyapatite thin film prepared by sputtering technique for medical applications; and hydroxyapatite application in dentistry and maxillofacial surgery. (Imprint: Nova Biomedical ). ...
Nanoparticles based on hydroxyapatite (NPs) have many useful physicochemical and biological properties, such as easy preparation and modification, as well as biocompatibility, which make them suitable for transport and unloading of various pharmaceuticals. Hydroxyapatite nanoparticles coated with bioresorbable polymers have been successfully used as carriers of antibiotics and vitamins in bone tissue engineering. In this study, we have investigated the synthesis of nanoparticles of hydroxyapatite and hydroxyapatite coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. The influence of the processing technique on the structure and characteristics of the obtained particles was studied by X-ray diffraction (XRD), particle size distribution analysis (PSD), Fourier transform infrared spectroscopy (FTIR), zeta potential analysis (ZP) and scanning electronic microscopy (SEM). In applied research, an appropriate radioisotope (Iodine-125) was selected and it was ...used to ...
The aim of the study was to evaluate the histological response and dimensional ridge alterations following application of a nanocrystalline hydroxyapatite paste (NHA) into fresh extraction sockets in dogs. Immediately following vertical tooth separat
PMID: 10212540 Two hydroxyapatite-coated implants were retrieved after 12 months of loading because of a fracture of the abutments. The specimens were treated to obtain thin ground sections, and a microprobe chemical analysis was done under a scanning electron microscope equipped with an energy-dispersive x-ray analysis and cathodoluminescence system. Under light microscopy, close contact between the bone and the hydroxyapatite coating was seen, with no gaps at the interface. In some areas of the coating a reduction of the coating thickness could be observed, along with the presence of some detached hydroxyapatite particles embedded in newly formed bone. The chemical analysis of the cathodoluminescent areas at the interface showed a reduced calcium:phosphorus ratio in this region. (Int J Oral Maxillofac Implants 1999;14:233 238) Key words: cathodoluminescence, hydroxyapatite, interface, osseointegration, titanium implants ...
The role of collagen fibres in biological bone-bonding of crystalline hydroxyapalite implant was analyzed. The mechanism involved interdigitation of collagen fibres into the surface layers of implant material. It was found that the bonding zone consists of nano-sized crystallites and organic bone matrix of collagen fibres. It was also found that the incorporation of collagen fibres with hydroxyapatite was necessary in the toughening and strengthening of bone bonding ...
Radiesse (Bioform Inc, USA) is a sterile, latex-free, non-pyrogenic, semi-solid, cohesive subdermal, injectable implant, whose principal component is synthetic calcium hydroxylapatite, a biocompatible material with over 20 years of use in medicine. T
Jayne Furlong, also referred to as Jane Furlong, was a New Zealand girl from Auckland who disappeared from a street in Auckland on 26 May 1993 while working in the sex trade. She had been abducted and murdered. Her remains were found south west of Auckland at Sunset Beach, Port Waikato, on 19 May 2012 after being exposed by erosion of a sandbank. They were positively identified by DNA. At the time of her disappearance, Furlong was due to testify as a witness for the prosecution in two separate legal cases - one involving gang members accused of an assault, and the other relating to a businessman charged with brutal attacks on sex workers. Furlongs ex-partner, who reported her missing on 28 May 1993, has refused to speak to police ever since her bodily remains were found. In 2012, after the remains were found, police released a film made in 1993 for the Crimewatch TV-program. The film shows a re-enactment of street scenes at the time Furlong went missing, with her boyfriend playing himself and ...
Modern day tissue engineering and cellular therapies have gravitated toward using stem cells with scaffolds as a dynamic modality to aid in differentiation and tissue regeneration. Mesenchymal stem cells (MSCs) are one of the most studied stem cells used in combination with scaffolds. These cells differentiate along the osteogenic lineage when seeded on hydroxyapatite containing scaffolds and can be used as a therapeutic option to regenerate various tissues. In recent years, the combination of hydroxyapatite and natural or synthetic polymers has been studied extensively. Due to the interest in these scaffolds, this review will cover the wide range of hydroxyapatite containing scaffolds used with MSCs for |i|in vitro|/i| and |i|in vivo|/i| experiments. Further, in order to maintain a progressive scope of the field this review article will only focus on literature utilizing adult human derived MSCs (hMSCs) published in the last three years.
Disclosed is an orthopedic and dental implant ceramic composition comprising hydroxyapatite and whitlockite. Said composition is prepared by blending 50 to 99.5% by weight of a crystalline hydroxyapatite and 0.5 to 50% by weight of whitlockite, and then, sintering the blend at a temperature of 900 to 1,400 C. Said crystalline hydroxyapatite is prepared by the solid phase reaction wherein a mixture of a calcium phosphate, having a Ca/P ratio of 1.5 to 1.67 by mole, and a stoichiometric amount or more of a calcium compound is heated at a temperature of 500 to 1,000 C. Said calcium compound is at least one compound selected from the group consisting of CaCO3, CaO, Ca(OH)2, CaF2, Ca(COO)2, Ca(NO3)2 and CaCl2.
Systems for targeted delivery of drugs with high affinity for specific organs, tissues, and cells were introduced at the beginning of the twentieth century. Recently, this concept is attracting much attention. These systems have shown most effective in reducing adverse effects of drugs. In recent years, scientists have created a system of nanoparticles for delivery of vitamin D. Special attention is paid to the role of vitamin D in the division and differentiation of osteoblasts and thus, in its role in osteogenesis. In this regard it was interesting to observe the local effects of the active form of vitamin D3 in osteogenesis, as a part of the system for local delivery. These effects were observed on an experimental model. Three types of nanobiomaterial were implanted in the artificially made defects in rats mandibular bone. Six weeks after implantation of hydroxyapatite, hydroxyapatite-coated vitamin D3 and hydroxyapatite nanoparticles coated with vitamin D3 mixed with the polymer, ...the ...
It is observed that good strength results are obtained by the compression to low pressures, what can suggest us that we are in the pressures frontier that causes overpressing in the material after the sintering process.. The proposed polynomial was: Y = b0 + b1X1 + b2X2 + b3X3 + b12X1X2 + b13X1X3 + b23X2X3 + b123X1X2X 3 + b33X32 + b133X1X3 2 + b233X2X3 2. For DTS we thought about quadratic terms of temperature, only variable with three levels, what presupposes their importance in the analysis. The resulting polynomial DTS = 7.2575 - 1.86 p + 6.03375 T + 5.68125 T2 shows the temperature influence, because the linear and quadratic terms are significant to the statistical analysis. Besides, a small inverse influence of the pressure is observed. A slight increment of the DTS exists as the pressure value decreases. The biggest values of DTS were obtained at 1200oC.. For density, the resulting polynomial was r = 1.47375 + 0.2965 T - 0.245 T2 + 0.0655 PT + 0.01625 hT2 - 0.09125 PT2, where the ...
Ethanol is currently the most common liquid fuel derived from biomass in the world, used primarily as a blendstock in gasoline-powered vehicles. In the next 20 years, demand is anticipated to grow in heavier, C8-22 distillate-range fuels such as diesel and jet while that of gasoline is projected to decrease,1 motivating research efforts into the conversion ethanol to heavier fuels.2 Coupling of ethanol via the Guerbet pathway has been examined mainly as a means to produce 1-butanol, which has improved gasoline fuel properties compared to ethanol.3-4 Ethanol coupling beyond 1-butanol is possible, resulting in both linear and branched C6+ alcohols.5-6 The potential of using alcohol coupling to produce distillate-range alcohols from ethanol is largely unknown since coupling beyond 1-butanol is seldom-studied and complicated by several complexities which arise at elevated conversions (,30%). Here we discuss the use of kinetic modeling to understand how inhibition by byproduct water and differences ...
Journal of Nanomaterials is a peer-reviewed, Open Access journal that aims to bring science and applications together on nanoscale and nanostructured materials with emphasis on synthesis, processing, characterization, and applications of materials containing true nanosize dimensions or nanostructures that enable novel/enhanced properties or functions. It is directed at both academic researchers and practicing engineers. Journal of Nanomaterials will highlight the continued growth and new challenges in nanomaterials science, engineering, and nanotechnology, both for application development and for basic research. All papers should emphasize original results relating to experimental, theoretical, computational, and/or applications of nanomaterials ranging from hard (inorganic) materials, through soft (polymeric and biological) materials, to hybrid materials or nanocomposites.
Low prices on Microcrystalline Hydroxyapatite! Beneficial form of supplemental calcium. Microcrystalline calcium hydroxyapatite compound (MCHC) is an extract of young bovine bone. Studies in Britian showed it to be an extremely bioavailable form of calcium that helped prevent bone loss and restore bone mineral content.*
Several tapered stems with similar geometry and extensive hydroxyapatite coating have recently been introduced. It is not clear, however, whether they shar
Adult subcutaneous fat tissue is an abundant source of multipotent cells. Previous studies from our laboratory have shown that, in vitro, adipose-derived adult stem (ADAS) cells express bone marker proteins including alkaline phosphatase, type I collagen, osteopontin, and osteocalcin and produce a mineralized matrix as shown by alizarin red staining. In the current study, the ADAS cell ability to form osteoid in vivo was determined. ADAS cells were isolated from liposuction waste of three individual donors and expanded in vitro before implantation. Equal numbers of cells (3 x 10(6)) were loaded onto either hydroxyapatite/tricalcium phosphate (HA-TCP) cubes or the collagen/HA-TCP composite matrix, Collagraft, and then implanted subcutaneously into SCID mice. After 6 weeks, implants were removed, fixed, and demineralized and sectioned for hematoxylin and eosin staining. Osteoid formation was observed in 80% of HA-TCP implants loaded with ADAS cells. Only 20% of Collagraft implants were positive ...
A bone repair material is described that is of putty-like consistency, particularly useful for repairing dental bony defects such as those caused by bone loss resulting from moderate or severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone-derived or derived from bone-like hydroxyapatite or synthetic hydroxyapatite; and, a resorbable carrier, such as high molecular weight polysaccharides, such as hyaluronic acid. A high concentration of particulate in the putty enhances bone repair and requires a high concentration of carrier to retain the putty at the defect site. For a particulate density of about 1.2 g/cc such as PEPGEN P-15 Bone Graft, a preferred formulation comprises about 55% percent by weight of the putty suspended in a hyaluronic acid gel of about 1.4 x 106 daltons molecular weight and a final concentration of about 56 mg/cc which material
Hydroxyapatite is chemically similar to hard tissues in mammals as well as mineral component of bones. Hydroxyapatite is classed as bioactive - it will support bone ingrowth and Osseo integration when used in orthopedic, dental, and maxillofacial applications.Rising demand for hydroxyapatite, owing to increasing dem...
Calcium, Bone, Bone Regeneration, Hydroxyapatite, Regeneration, Fibroblast, Fibroblast Growth Factor, mRNA, Rabbits, Calcium Hydroxyapatite, Titanium, Teeth, Cell, Alkaline Phosphatase, Basic Fibroblast Growth Factor, Bone Formation, Cell Proliferation, Femurs, Osteoblasts, Osteocalcin
Bone defects due to trauma or disease have led to the need for biomaterials as substitutes for tissue regeneration and repair. Herein, we introduce a porous triphasic ceramic-coated hydroxyapatite scaffold (HASi) for such applications. Interestingly, in the degradation experiments with isotonic buffer, HASi showed a significant release of silica with the disappearance of the tricalcium phosphate phase. Furthermore, the material also exhibited cytocompatibility with cultured bone marrow-derived mesenchymal stem cells of human origin. The material chemistry, together with the favorable cellular characteristics, indicates HASi as a promising candidate for critical-size bony defects, which still remains a formidable clinical challenge in the orthopedic scenario.
In this study, we describe a sensitive protocol for the detection of bladder cancer cells in a patients urine without pre-treatment of the urine sample using antibody-modified hydroxyapatite (HAp) micro/nanostructured surfaces converted from natural seashells under mild biomineralization conditions. The mec
The response of human bone marrow cell to bone ash-derived hydroxyapatite (HA) and tuna bonederived HA powders was compared. HA ceramics were prepared from the commercial..
Specialized manufacturer and supplier of synthetic nano-hydroxyapatite and tricalcium phosphate materials marketed as nanoXIM, used to manufacture medical devices, oral care and food products.
Specialized manufacturer and supplier of synthetic nano-hydroxyapatite and tricalcium phosphate materials marketed as nanoXIM, used to manufacture medical devices, oral care and food products.
Microcrystalline Calcium Hydroxyapatite Compound, or MCHC, is actually a bone-setting up supplement with that may have excellent absorption in comparison to calcium. As it contains every one of the minerals The natural way transpiring in healthy bone in the proper proportions, combined with the other Energetic and supportive constituents of bone, MCHC makes an extensive bone aid complement. Calcium is often a mineral involved with many different features of your body, and MCHC is a concentrate of entire bone. As a result, MCHC consists of calcium, but calcium is only one of a number of factors needed to help build and retain strong bones ...
Microcrystalline Calcium Hydroxyapatite Compound, or MCHC, can be a bone-developing supplement with which will have excellent absorption in comparison to calcium. Mainly because it is made up of all the minerals In a natural way happening in healthy bone in the ideal proportions, together with the other active and supportive constituents of bone, MCHC can make an extensive bone assistance nutritional supplement. Calcium is usually a mineral involved in a number of capabilities of the body, and MCHC is often a focus of full bone. As such, MCHC is made up of calcium, but calcium is just one of a variety of components necessary to assist build and keep powerful bones ...
It enables the quantitative determination of bone mineral content of the lumbar spine in mg/ml of calcium hydroxyapatite for the diagnosis and follow-up of osteoporosis with CT. The patient is scanned together with the water- and bone-equivalent reference phantom.. Capabilities include:. ...
Results of 120 consecutive revision hip replacements in 107 patients, using the JRI Furlong hydroxyapatite-ceramic-coated femoral component. S.P. Trikha et al, Worthing & Southlands NHS Trust, Worthing, England J Bone Joint Surg [Br] 2005;87-B:1055-60 ...
Answer: Deposition of calcium (hydroxyapatite) in the epithelial basement mermbrane, Bowmans layer, and superficial stroma. Generally the factors leading to calcium deposition are the concentration of calcium in the tear film and the soluability, which is related to the phosphorus concentration and the pH ...
MMP-2, MMP-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapatite particles.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
HA Ultrogel® is a composite material of cross-linked agarose and microcrystalline hydroxyapatite enclosed in the agarose matrix. The material shows mixed mode functionality based on cation exchange and metal affinity in the hydroxyapatite structure. A wide variety of applications include separation of proteins, peptides and nucleic acids, from laboratory to production scale.
See details for 2014 Edgehill Drive, Furlong, PA 18925, 4 Bedrooms, 3 Full/2 Half Bathrooms, 4526 Sq Ft., Single Family, MLS#: PABU2003324, Status: Pending, Courtesy: RE/MAX Centre Realtors, Provided by: Long and Foster
A 1964 Volkswagen Beetle measures 0.02028 furlongs. As the longest continuously-produced automobile design - in production for 75 years between 1938 and 2003 - the Beetle was voted the most fourth-most influential car of the twentieth century by the Global Automotive Elections Foundation. ...
Frederick Thomas Furlong: current contact information and listing of economic research of this author provided by RePEc/IDEAS
McAlees, E., Vollebregt, P. F., Stevens, N., Dudding, T. C., Emmanuel, A. V., Furlong, P. L., Hamdy, S., Hooper, R. L., Jones, J. F. X., Norton, C., OConnell, P. R., Scott, S. M. & Knowles, C. H., 26 Jun 2018, In : Trials. 19, 1, 336.. Research output: Contribution to journal › Article ...
Troubled actor Edward Furlong exposed his 6-year-old son to cocaine and should NOT be allowed to be near the child without strict supervision ... this…
Troubled actor Edward Furlong exposed his 6-year-old son to cocaine and should NOT be allowed to be near the child without strict supervision ... this…
Mineralization of collagen is a common combination process mainly involving collagen self-assembly and hydroxyapatite formation. Previous measurement of tu
Scientific, peer-reviewed Dermatology article, indexed with MEDLINE/PubMed: Optimizing Facial Rejuvenation Outcomes by Combining Poly-L-Lactic Acid, Hyaluronic Acid, Calcium Hydroxylapatite, and Neurotoxins: Two Case Studies : Reversal of the visible signs of facial aging with the use of injectable products as an alternative to surgery has become more popular, with nearly 5 million procedures performed in the United States in 2012. Volume augmentation products, such as hyaluronic acid (HA), calcium hydroxylapatite (CaHA), and poly-L-lactic acid (PLLA), are often used in combination with one another and with neurotoxins for facial rejuvenation because of the complementary modes of action. This article presents 2 case reports involving patientspecific combinations of 2 different HA products, injectable PLLA, and CaHA with incobotulinumtoxinA or abobotulinumtoxinA. The combination of HA, CaHA, PLLA, and neurotoxins has resulted in outstanding outcomes for many patients, with no clinical evidence of
The applicative potential of synthetic calcium phosphates, especially hydroxyapatite (HAp), has become intensely broadened in the past 10 years, from bone tissue engineering to multiple other fields of biomedicine. Previously we have shown that hydroxyapatite nanoparticles coated with chitosan-poly(D,L)-lactide-co-glycolide (HAp/Ch-PLGA) target lungs following their intravenous administration into mice. For this purpose radioactive 125-Iodine (125I), a low energy gamma emitter, was used to develop a novel in situ method for radiolabeling of particles and investigation of their biodistribution. In this study we utilize an emulsification process and freeze drying to load the composite particles based on hydroxyapatite nanocarrier, chitosane and poly(lactic-co-glycolic acid) with 17β- hydroxy-17α-picolyl-androst-5-en-3β-acetate (A), a chemotherapeutic derivative of androstane. The picolyl androstane derivatives showed high potency in the cell inhibitors of hormonedependent cancers ...
INJECTION FOR LIPS AND SMILE LINES BEATS HYALURONIC ACID. Radiesse® is a new injectable product for lip enlargement and filing of folds and lines of the skin of the face. The advantage of this product is its potential for a long lasting effect, perhaps several years or longer.. Radiesse® consists of calcium hydroxyapatite suspended in a gel of carboxymethylcellulose. Because calcium hydroxyapatite is a normal constituent of bone, it does not elicit a chronic inflammatory or immune response. For this reason, it is unnecessary to undergo skin testing, as required with collagen.. Calcium hydroxyapatite has been used in humans for a long time in prosthetic implants in dental, facial and orthopedic surgery. Injection of Radiesse® into the vocal cords and the bladder neck has shown that the product remains soft when injected into soft tissue and may last for years. Studies from Italy and suggest that Radiesse shows promise as a new agent for facial contouring with no serious side effects and ...
Herein, we report the preparation and characterization of rhodium(0) nanoparticles supported on hydroxyapatite (Ca-10(OH)(2)(PO4)(6), HAP) and their catalytic use in the hydrolysis of hydrazine-borane, which attracts recent attention as promising hydrogen storage materials. Hydroxyapatite supported rhodium(0) nanoparticles were readily prepared by the hydrazine-borane reduction of rhodium(III)-exchanged hydroxyapatite in situ during the hydrolysis of hydrazine-borane at room temperature. Characterization of the resulting material by ICP-OES, TEM, SEM, EDX, XRD, XPS spectroscopies and N-2 adsorption-desorption technique, which shows the formation of rhodium(0) nanoparticles well dispersed on hydroxyapatite support. The catalytic performance of these new supported rhodium(0) nanopaiticles in terms of activity, lifetime and reusability was tested in the hydrolysis of hydrazine-borane. They were found to be highly active, long-lived and reusable catalyst in this important catalytic reaction even at ...
TY - JOUR. T1 - The deposition of strontium and zinc Co-substituted hydroxyapatite coatings. AU - Robinson, L.. AU - Salma-Ancane, K.. AU - Stipniece, L.. AU - Meenan, Brian. AU - Boyd, A. R.. N1 - Compliant in UIR; evidence uploaded to Other files Date: Jan 04, 2017 To: Adrian Boyd [email protected] From: Journal of Materials Science: Materials in Medicine (JMSM) [email protected] Subject: JMSM-D-16-00530R1 - Editor Decision Dear Dr. Boyd, We are pleased to inform you that your manuscript, The Deposition of Strontium and Zinc Co-substituted Hydroxyapatite Coatings, has been accepted for publication in Journal of Materials Science: Materials in Medicine. You will receive an e-mail from Springer in due course with regards to the following items: 1.Offprints 2.Colour figures 3.Transfer of Copyright Please remember to quote the manuscript number, JMSM-D-16-00530R1, whenever inquiring about your manuscript. Best regards, Divya Ananthanarayanan Springer Journals Editorial ...
Аннотация доклада: Alpha-emitters are of the great interest for nuclear medicine due to the high linear energy transfer of α-particles and recoil nuclei. A pathlength of α-particles in biological tissue is much less than that of β-particles and comparable to a cell size (10-100 µm). Being delivered to the tumor cells, α-particles provide its targeted destruction and minimal damage to surrounding organs. Among various α-emitters, 223Ra is one of the promising candidates for targeted α-therapy. A radiopharmaceutical Xofigo® on the basis of 223RaCl2 is registered and produced by Bayer Company for the therapy of bone metastases. Another approach is a targeted delivery of 223Ra using various transporters to the cancer cells such as peptides, liposomes or various inorganic carriers. Hydroxyapatite (HAP) particles could be considered as possible carriers of Ra. Two different approaches to HAP labeling were tested: sorption of Ra on pre-synthesized HAP-particles and insertion of ...
In this study one of classical antibiotic compound nitrofurantoin was studied as micro and nano particles in electrochemical analysis by cyclic voltammetric technique using glassy carbon electrode in blood medium to observe the oxidative effect on the blood components. It was found oxidation - reduction current peaks of nitrofurantoin in blood medium at +1 and -0.75 V respectively. The oxidation current peak was disappeared for the nitrofurantoin nano particles in blood medium, but for micro particles is still oxidize the blood. Different concentration and scan rate were studied to observation the electrochemical behavior of nitrofurantoin nano particles in blood medium which has good analysis.
CALCIUM-MAGNESIUM ZINC Dietary Supplement Vegetarian/Kosher Target-Mins are complexed with specific free form amino acids and other carriers for optimum mineral transport. Supplement Facts: Serving Size 3 tablets Servings Per Container 30 Amount Per Serving - % Daily Value Vitamin D (as ergocalciferol) 200IU 50% Calcium (as calcium hydroxyapatite, citrate, aspartate, alpha-ketoglutarate, lysinate) 1,000mg 100% Phosphorus (as calcium hydroxyapatite) 500mg 50% Magnesium (as magnesium aspartate, oxide, citrate, taurinate, alpha-ketoglutarate) 500mg 125% Zinc (as zinc citrate, histidinate picolinate, alpha-ketoglutarate, aspartate) 25mg 167% Directions: Adults take three (3) tablets daily. For best utilization, take with food. Other Ingredients: Cellulose, stearic acid, cellulose & glycerin coating, silica. Does Not Contain: Corn, wheat, soy, gluten, milk, salt, sugar, starch, preservatives or artificial color.
TY - GEN. T1 - Pecvd SiOx accelerates hydroxyapatite surface formation for enhanced early osteogenic differentiation. AU - Velten, M. F.. AU - Odatsu, T.. AU - Aswath, P. B.. AU - Kamiya, N.. AU - Kim, H.. AU - Varanasi, V. G.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Current metal implants are designed to structurally support the surrounding bone upon fracture. However, they have long healing times as they do not form an apatite surface layer for direct bone bonding and do not enhance osteogenesis. In this study, we use amorphous silica (SiOx) nanolayers as a potential implant coating material to improve bone healing. The aim of this study is to determine the ability of SiOx nanolayers to enhance osteogenic differentiation via rapid surface hydroxyapatite (HA) formation. SiOx nanolayers are prepared using plasma enhanced chemical vapor deposition. These nanolayers are also etched with grooves to facilitate osteoprogenitor attachment. Immersion of these nanolayers in-vitro showed a decrease in the ...
Implant fixation in bone can be improved by a coating that delivers bisphosphonates locally, or by a hydroxyapatite (HA) coating. In this study, we compared these different types of coatings. For mechanical testing, 30 rats were assigned into three groups, and similar screws were implanted bilaterally in the proximal tibiae. The rats received screws that were either uncoated, coated with nano-crystalline hydroxyapatite or coated with a bisphosphonate releasing protein matrix. After 4 weeks, one screw was subjected to pull-out testing, and the contra-lateral one to torsion testing. For morphology, 30 rats were assigned to similar treatment groups, but received only one screw each. Bisphosphonates enhanced the pull-out force by 41% (P = 0.02) compared to controls, HA increased the pull-out force although not significantly. Conversely, HA increased the maximal torque by 64% (P = 0.02). Morphometry showed higher bone volume around bisphosphonate screws in comparison to HA-coated screws (P andlt; ...
Fingerprint Dive into the research topics of Milwaukee shoulder-association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. ii. synovial fluid studies. Together they form a unique fingerprint. ...
TY - CONF AU - Gyorgy, E. AU - Grigorescu, S. AU - Socol, Gabriel AU - Mihailescu, Ion N. AU - Janaćković, Đorđe AU - Dindune, Antonija AU - Kanepe, Z. AU - Palcevskis, Eriks AU - Zdrentu, E. L. AU - Petrescu, S. M. PY - 2007 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1170 AB - Bioactive glass (BG), calcium hydroxyapatite (HA), and ZrO2 doped HA thin films were grown by pulsed laser deposition on Ti substrates. An UV KrF* (lambda = 248 nm, tau gt = 7 ns) excimer laser was used for the multi-pulse irradiation of the targets. The substrates were kept at room temperature or heated during the film deposition at values within the (400-550 degrees C) range. The depositions were performed in oxygen and water vapor atmospheres, at pressure values in the range (5-40 Pa). The HA coatings were heat post-treated for 6 h in a flux of hot water vapors at the same temperature as applied during deposition. The surface morphology, chemical composition, and crystalline quality of the obtained thin ...
Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.. http://laurel.lso.missouri.edu/record=b4177860~S5. ...
In this study, we aimed at generating osteogenic and vasculogenic constructs starting from the stromal vascular fraction (SVF) of human adipose tissue as a single cell source. SVF cells from human lipoaspirates were seeded and cultured for 5 days in porous hydroxyapatite scaffolds by alternate perfu …
TY - JOUR. T1 - Kinetic and mechanism studies of the adsorption of lead onto waste cow bone powder (WCBP) surfaces. AU - Cha, Jihoon. AU - Cui, Mingcan. AU - Jang, Min. AU - Cho, Sang Hyun. AU - Moon, Deok Hyun. AU - Khim, Jeehyeong. N1 - Funding Information: Acknowledgments This study was supported by the Korea Ministry of Environment as the GAIA (Geo-Advanced Innovative Action) Project (No. 173-091-003). PY - 2011. Y1 - 2011. N2 - This study examines the adsorption isotherms, kinetics and mechanisms of Pb2+ sorption onto waste cow bone powder (WCBP) surfaces. The concentrations of Pb2+ in the study range from 10 to 90 mg/L. Although the sorption data follow the Langmuir and Freundlich isotherm, a detailed examination reveals that surface sorption or complexation and co-precipitation are the most important mechanisms, along with possibly ion exchange and solid diffusion also contributing to the overall sorption process. The co-precipitation of Pb2+ with the calcium hydroxyapatite (Ca-HAP) is ...
Arguably the most serious problem with most current nutrient risk assessment methodologies is that they are based upon the assessment of entire nutrient groups (e.g. vitamin D, vitamin E, calcium, zinc or iron), as opposed to individual nutrient forms (egg vitamin D3, gamma-tocopherol, calcium hydroxyapatite, zinc sulphate or iron bisglycinate).. Why is this important? Because, in short, the supposed risks from consuming a particular vitamin or a mineral are highly dependent upon the chemical form in which it is presented.. For example, ferrous sulphate, commonly prescribed by medical doctors to treat anaemia, is generally recognized as the most toxic form of iron, and can potentially cause a number of unpleasant side effects, including gastro-intestinal discomfort and nausea. However, iron bisglycinate, the form widely recommended by clinical nutritionists and nutritional therapists is a far gentler form of iron, and does not share the unpleasant the side effects of its relatively more toxic ...
Neauvia Organic Hydro Deluxe Man contains 18 mg/ml of pure hyaluronic acid derived from Bacillus subtilis. Such high concentration allows to obtain very good results noticeable from the first treatment. In addition, Neauvia Organic Hydro Deluxe Man is enriched with 0,01% of calcium hydroxyapatite and two amino acids. In addition to hyaluronic acid it contains amino acids - Glycine and L-Proline - that are main ingredients of collagen. This unique composition activates and supports natural processes of collagen production, thanks to which skin becomes thicker and firmer.. A series of 4 treatments with 3 week intervals between all treatments should be performed to achieve optimal results. At the end of the series, in order to maintain results, it is worth offering to a patient a follow-up treatment scheduled for half a year later. ...
This paper reports on the hybrid process we have used for producing hierarchical scaffolds made of poly(lactic-co-glycolic) acid (PLGA) and nanohydroxyapatite (nHA), analyzes their internal structures via scanning electron microscopy, and presents the results of our in vitro proliferation of MC3T3-E1 cells and alkaline phosphatase activity (ALP) for 0 and 21 days. These scaffolds were produced by combining additive manufacturing (AM) and thermally induced phase separation (TIPS) techniques. Slow cooling at a rate of 1.5 °C/min during the TIPS process was used to enable a uniform temperature throughout the scaffolds, and therefore, a relatively uniform pore size range. We produced ten different…. ...
The limitations in the transport of oxygen, nutrients, and metabolic waste products pose a challenge to the development of bioengineered bone of clinically relevant size. This paper reports the design and characterization of hierarchical macro/microporous scaffolds made of poly(lactic-co-glycolic) acid and nanohydroxyapatite (PLGA/nHA). These scaffolds were produced by combining additive manufacturing (AM) and thermally induced phase separation (TIPS) techniques. Macrochannels with diameters of ∼300 μm, ∼380 μm, and ∼460 μm were generated by embedding porous 3D-plotted polyethylene glycol (PEG) inside PLGA/nHA/1,4-dioxane or PLGA/1,4-dioxane solutions, followed by PEG extraction using deionized (DI) water. We have used an I-optimal design of experiments…. ...
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Page contains details about nanofiber-peptide hydrogel-coated nano-hydroxyapatite/collagen . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
hole zones: within collagen type I; initial site of mineral deposition; osteocalcin (Gla protein): noncollagen organic material, binds calcium during mineralization osteonectin: serves bridging function between collagen and mineral component sialoproteins: rich in sialic acid; concentrated from plasma hydroxyapatite: mineral component of bone; calcium and phosphate; conjugated to small proportion magnesium carbonate, sodium and potassium ions; affinity for heavy metal and radioactive environmental pollutants; note: 20% or more of mineral component remains amorphous pyrophosphate: inhibitor calcium deposition; crucial for controlling bone mineralization matrix vesicles: membrane bound vesicles derived from osteoblast plasma membrane; contain alkaline phosphatase and other phosphatases; neutralize effect of pyrophosphate. ...
In order to obtain the properties of the sintered as-dried calcium phosphate with [Ca]/[P] = 1.50, the characteristics of sintered pellets have been investigated using X-ray diffraction (XRD), inductively coupled plasma-mass spectrometry (ICP-MS), Fourier-transform infrared (FT-IR) spectra, Vickers hardness indentation and scanning electron microscopy (SEM). When the pellet samples were sintered between 700 °C and 1200 °C for 4 h, the hydroxyapatite (Ca10(PO4)6(OH)2, HA) still maintained the major phase, accompanied with the rhenanite (NaCaPO4) as the secondary phase and β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP) as the minor phases. In addition, the HA partially transformed to α-tricalcium phosphate (α-Ca3(PO4)2, α-TCP) and tetracalcium phosphate (Ca4(PO4)2O, TTCP), when the pellet samples were sintered at 1300 °C and 1400 °C, respectively, for 4 h. The maximum density and Vickers Hardness (HV) of sintered pellet samples were 2.85 g/cm3 (90.18% theoretical density (T.D.)) and 407, which
TY - JOUR. T1 - Synthesis of hydroxyapatite contining manganese and its evaluation of biocompatibility. AU - Fujitani, Wataru. AU - Hamada, Yoshinosuke. AU - Kawaguchi, Naomasa. AU - Mori, Seiji. AU - Daito, Kiyoshi. AU - Uchinaka, Ayako. AU - Matsumoto, Takuya. AU - Kojima, Yoshihisa. AU - Daito, Michiharu. AU - Nakano, Takayoshi. AU - Matsuura, Nariaki. PY - 2010. Y1 - 2010. N2 - Biomaterials made using hydroxyapatite (HAp) and calcium phosphates, which are inorganic components of hard tissues, have been developed to fill bone defects caused by various diseases. A biomaterial of HAp containing collagen, an organic component of bone, has also been developed. However, the physical and biological functions of these bone biomaterials remain inadequate. Focusing on Zinc(Zn) and Manganese(Mn) ions out of the divalent cations involved in the ac- tivity of integrins, which are molecules existing in cell membranes, we synthesized three kinds of inorganic biomaterials-pure HAp, Zn-containing HAp ...
Embedding nano size CoFe2O4 ferrite particles in a hydroxyapatite (HAP) host would make them to better candidates for hyperthermia treatment of cancer. The formation of nano crystallites of CoFe2O4 ferrites in the hydroxyapatite Ca10-3xFe2xCox(PO4)6(OH)2 (where x= 0, 0.1, 0.2, 0.3, 0.4 and 0.5 %mole) mixtures heated to temperatures between 500 and 1250°C for 2 hrs.
Mayson finished third in the six furlong Cammidge Trophy at Doncaster on his re-appearance as a four-year-old.[4] He gained his first Listed success when winning the Abernant Stakes. Ridden by Paul Hanagan he started at 4/1 and was ridden near the front of the 10-runner field. As they entered the final furlong he took the lead and ran on to win by three and a half lengths from the gelding Jimmy Styles,[8] gaining his first victory for twenty months. He followed this up with his first Group win in the Palace House Stakes two weeks later. He started as the 7/2 favourite and was in the middle of the pack early on in the race. As he had done in the Abernant Stakes, he took the lead entering the final furlong and went on to win by three quarters of length from Definightly, who just beat Elusivity for second place.[9] He finished in last place, tailed off behind winner Tiddliwinks, in the Duke of York Stakes.[10] He then finished in fifth place in the Chipchase Stakes after being hampered with over a ...
Mineralization of collagen is a common combination process mainly involving collagen self-assembly and hydroxyapatite formation. Previous measurement of turbidity showed that collagen self-assembly follows the nucleation-growth model. In the present study, 1.0 M CaCl₂ was mixed with 0.6 mg/mL collagen solution in PBS (10 mM phosphate, 80 mM NaCl, pH 7.2, and T = 35 °C) at the beginning of the lag ...
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The nanoindentation of a columnar grain boundary (GB) network in nanocrystalline Al has been examined by atomistic simulation. Our intent was to gain fundamental understanding on the relationship between structure evolution at GBs and incipient plasticity for indenter tips significantly larger than the average grain size. The nanoindentation simulations were performed by quasicontinuum method at zero temperature. A GB network made of vicinal and high-angle |110| tilt GBs was produced by generating randomly-oriented 5-nm grains at the surface of a 200 nm-thick film. The major findings of this investigation are that (1) nanocrystalline GB networks profoundly impact on the nanoindentation response and cause significant softening effects at the tip/surface interface; (2) GB movement and deformation twins are found to be the predominant deformation modes in columnar Al, in association with shear band formation by GB sliding and intragranular slip, and crystal growth by grain rotation and coalescence; and (3)
The dynamics of nanocrystalline materials has attracted a lot of scientific interest during the last decade due to the striking differences observed for their atomic vibrations relative to the bulk counterparts. These anomalies are the enhancement of their density of phonon states (DOS) at low and high energies and broadening of the phonon peaks [1]. In addition, the energy dependence of the low-energy part of their phonon DOS has been a source of long-standing debates. The experimental results are contradictory, reporting a linear dependence [2], a power law with n = 1.33 [3], and a quadratic (Debye-like) behaviour ([4, 5], and references therein). On the other hand, the theoretical calculations have also indicated that non-Debye dynamics could originate from the atoms located at the surfaces [6], at the grain boundaries [7], or in the porous areas [8] of the nanocrystalline materials. Therefore the thorough understanding of the atomic dynamics in these materials is of significant importance ...
Nano-Hydroxyapatite (nHAP) is a very valuable mineral that is widely used in tissueengineering as well as bone and dental repair. Moreover, it is a major component of bone, enamel and dentin that can interact effectively with healing tissues due to its high biocompatibility. It is important to note that the purpose of its medical application can be identified based on the structure and synthesis of HAP. This study aimed to efficiently review all the previously conducted studies on synthesis and application of nHAP over the years of researchers efforts and present the results for optimizing biocompatible material synthesis.
SCRATCHED) came to Aqueduct, she was a buzz horse, hot off two wins at Penn National by double-digit lengths, a speedster that left her competitors gasping in her wake.. The buzz was quieted by her slim loss in a restricted race that day in December, and in the Grade 2 Gazelle, shes facing challenges-like a layoff, distance and caliber of opponents-that she hasnt taken on before, but Brisnet nonetheless rates her top in the field. Tested for the first time last out, Behrniks Bank exhibited grit in a stirring stretch duel with eventual winner Frosty Margarita, refusing to yield until the final steps.. Will her grit and speed be enough to carry her to the wire first? Theres no doubting her talent, but shes never run beyond 6 furlongs; shes making her first start in nearly four months; and shes unlikely to get loose on the lead. Shed never been headed until her loss in December, but questions remain: can a pedigree light on stamina take the 9-furlong Gazelle? And even if it can-after so ...
Termagant made her racecourse debut in a maiden race over seven furlongs at Leopardstown Racecourse on 11 June and started a 14/1 outsider in a five-runner field. After being restrained in the early tages she went to the front a furlong out and broke clear of her opponents to win by two lengths from the Aidan OBrien-trained Cabaret.[7] After a break of two and a half months, the filly returned to the track and was moved up sharply in class to contest the Group 1 Moyglare Stud Stakes on heavy ground at the Curragh on 30 August. Lillie Langtry started favourite in the seven-runner field ahead of Long Lashes (winner of the Sweet Solera Stakes) and the Jim Bolger-trained Gile Na Greine with Termagant next in the betting on 16/1 alongside her stablemate Wrong Answer (Marble Hill Stakes). Termagant was settled in mid-division as the 66/1 outsider Famous set the pace from Gold Bubbles and Long Lashes, but made a forward move entering the last quarter mile. She took the lead approaching the final ...
take a look at the 2yo filly A.V. Flynn in the CTBA Stakes @ Del Mar today...she set the track record @ Pleasanton in her debut, smoking 5 furlongs in 21.55, 44.06, 55.92 (note the final furlong in under 12 seconds)...Pleasanton does run fast, but i checked the charts from thatr day, and this filly ran considerably faster than everyone else on the card...two hporses fromn that race have already returned to win, and shes trained by Steve Miyadi, who is hitting a whopping 32% from 245 starters (i guess you can add him to the list of super-trainers)...shes 3/1 on the morning line, but the fact shes coming out of a maiden claimer @ Pleasanton should keep the price fair...i like this filly a lot today.... ...
10.29.20 Congratulations to February Horse of the Month, Coventry owned by Lex at Winchester Racing!. 10.20.20 Congratulations to January Horse of the Month, Butterfly Kisses owned by Free at Blackwood Equestrian!. 09.14.20 Congratulations to December Horse of the Month, Hecate owned by Ripley at Battle Brook Stables!. 08.20.20 Congratulations to November Horse of the Month, Ashkenaz owned by Sunfrost at Stride of Perfection Stables!. 7.26.20 Congratulations to October Horse of the Month Hellion owned by Kenren at Valkyrie Stud!. ...
by Ceram . vehicle (e.g. acetone) to form a slurry before milling. The slurry must then be dried. Pellets can then be formed from the resulting powder using either hot or cold pressing at pressures of up to 135MPa. Finally, sintering is performed at up to 1250°C to crystallise the product. After this final stage Pramanik et al. [2] suggest recrushing the sintered samples followed by further compaction and sintering at 1250°C to refine the crystal structure, and reduce the grain (7-8µm) and crystal size (50-70nm). Despite reports of the production of single phase HA via this method it is highly likely that α-tricalcium phosphate (Ca3(PO4)2 - TCP) may be present in the final product due to the high temperatures required to initiate the reaction. The α-TCP phase may then be transformed to β-TCP during sintering; this is reported to occur at 1063°C [3]. If there is any incorporation of different calcium phosphate phases in the final product the dissolution and mechanical properties of the ...
Mikrostruktura hydroksyapatytowej powłoki zawierającej srebro, osadzonej na $CP-Ti$ techniką elektrolityczno-plazmowego utleniania - Microstructure of hydroxyapatite coating containing silver deposited on $CP-Ti$ by micro-arc oxidation / J. KARBOWNICZEK, G. CEMPURA, F. Muhaffel, H. Cimenoglu, S. Kayali, A. CZYRSKA-FILEMONOWICZ // W: XLII szkoła inżynierii materiałowej : Kraków-Rytro, 23-26 IX 2014 : monografia / pod red. Jerzego Pacyny ; Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydział Inżynierii Metali i Informatyki Przemysłowej. - Kraków : Wydawnictwo Naukowe AKAPIT, [2014]. - Na okł. tyt.: Prace XLII Szkoły Inżynierii Materiałowej. - ISBN: 978-83-63663-49-0. - S. 142-144. - Bibliogr. s. 144, Streszcz., Abstr.. - J. Karbowniczek, G. Cempura, A. Czyrska-Filemonowicz - afiliacja: Akademia Górniczo-Hutnicza ...
Graphitization of polymers is an effective way to synthesize nanocrystalline graphene on different substrates with tunable shape, thickness and properties. The catalyst free synthesis results in crystallite sizes on the order of a few nanometers, significantly smaller than commonly prepared polycrystalline g
Mineral: Mineral, naturally occurring homogeneous solid with a definite chemical composition and a highly ordered atomic arrangement; it is usually formed by inorganic processes. There are several thousand known mineral species, about 100 of which constitute the major mineral components of rocks; these are
Jockey John Velazquez was undergoing emergency surgery to have his spleen removed, according to his agent, Angel Cordero, after Velazquez was thrown to the ground when his mount Secret Compass, broke down with three furlongs remaining in Saturdays $2 million Breeders Cup Juvenile Fillies at Santa Anita.