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TY - JOUR. T1 - Biological advantages of porous hydroxyapatite scaffold made by solid freeform fabrication for bone tissue regeneration. AU - Kwon, Byeong Ju. AU - Kim, Jungsung. AU - Kim, Yong Hwa. AU - Lee, Mi Hee. AU - Baek, Hyun Sook. AU - Lee, Dae Hyung. AU - Kim, Hye Lee. AU - Seo, Hyok Jin. AU - Lee, Min Hyeon. AU - Kwon, Soon Young. AU - Koo, Min Ah. AU - Park, Jong Chul. PY - 2013/7/1. Y1 - 2013/7/1. N2 - Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of ...
TY - JOUR. T1 - Preparation, characterization and in vitro test of composites poly-lactic acid/hydroxyapatite scaffolds for bone tissue engineering. AU - Carfi Pavia, Francesco. AU - Ghersi, Giulio. AU - Brucato, Valerio Maria Bartolo. AU - Conoscenti, Gioacchino. AU - La Carrubba, Vincenzo. AU - Greco, Silvia. PY - 2018. Y1 - 2018. N2 - In this work, the possibility to produce composite Poly-L-lactic acid (PLLA)/Hydroxyapatite (HA) porous scaffolds via Thermally Induced Phase Separation (TIPS) for bone tissue engineering applications was investigated. Several PLLA/HA wt/wt ratios (95/5, 90/10, 70/30, 50/50, 34/66) were tested and the as-obtained scaffolds were characterized via Scanning Electron Microscopy, Wide Angle X-Ray Diffraction, Thermogravimetric analysis, Gas Pycnometry, Differential Scanning Calorimetry and mechanical compression test. Morphological analysis revealed an open structure with interconnected pores and HA particles embedded in the polymer matrix. Finally, cell cultures ...
Polymer ceramic composites obtained as the result of a mineralization process hold great promise for the future of tissue engineering. Simulated body fluids (SBFs) are widely used for the mineralization of polymer scaffolds. In this work an exhaustive study with the aim of optimizing the mineralization process on a poly(L-lactic acid) (PLLA) macroporous scaffold has been performed. We observed that when an air plasma treatment is applied to the PLLA scaffold its hydroxyapatite nucleation ability is considerably improved. However, plasma treatment only allows apatite deposition on the surface of the scaffold but not in its interior. When a 5 wt % of synthetic hydroxyapatite (HAp) nanoparticles is mixed with PLLA a more abundant biomimetic hydroxyapatite layer grows inside the scaffold in SBF. The morphology, amount, and composition of the generated biomimetic hydroxyapatite layer on the pores surface have been analyzed. Large mineralization times are harmful to pure PLLA as it rapidly degrades ...
Free Online Library: The effects of C[O.sub.2] laser with or without nanohydroxyapatite paste in the occlusion of dentinal tubules.(Research Article, Report) by The Scientific World Journal; Biological sciences Environmental issues Carbon dioxide lasers Health aspects Hydroxyapatites Oral surgery Methods
Nanoparticles based on hydroxyapatite (NPs) have many useful physicochemical and biological properties, such as easy preparation and modification, as well as biocompatibility, which make them suitable for transport and unloading of various pharmaceuticals. Hydroxyapatite nanoparticles coated with bioresorbable polymers have been successfully used as carriers of antibiotics and vitamins in bone tissue engineering. In this study, we have investigated the synthesis of nanoparticles of hydroxyapatite and hydroxyapatite coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. The influence of the processing technique on the structure and characteristics of the obtained particles was studied by X-ray diffraction (XRD), particle size distribution analysis (PSD), Fourier transform infrared spectroscopy (FTIR), zeta potential analysis (ZP) and scanning electronic microscopy (SEM). In applied research, an appropriate radioisotope (Iodine-125) was selected and it was ...used to ...
The aim of the study was to evaluate the histological response and dimensional ridge alterations following application of a nanocrystalline hydroxyapatite paste (NHA) into fresh extraction sockets in dogs. Immediately following vertical tooth separat
PMID: 10212540 Two hydroxyapatite-coated implants were retrieved after 12 months of loading because of a fracture of the abutments. The specimens were treated to obtain thin ground sections, and a microprobe chemical analysis was done under a scanning electron microscope equipped with an energy-dispersive x-ray analysis and cathodoluminescence system. Under light microscopy, close contact between the bone and the hydroxyapatite coating was seen, with no gaps at the interface. In some areas of the coating a reduction of the coating thickness could be observed, along with the presence of some detached hydroxyapatite particles embedded in newly formed bone. The chemical analysis of the cathodoluminescent areas at the interface showed a reduced calcium:phosphorus ratio in this region. (Int J Oral Maxillofac Implants 1999;14:233 238) Key words: cathodoluminescence, hydroxyapatite, interface, osseointegration, titanium implants ...
The role of collagen fibres in biological bone-bonding of crystalline hydroxyapalite implant was analyzed. The mechanism involved interdigitation of collagen fibres into the surface layers of implant material. It was found that the bonding zone consists of nano-sized crystallites and organic bone matrix of collagen fibres. It was also found that the incorporation of collagen fibres with hydroxyapatite was necessary in the toughening and strengthening of bone bonding ...
Radiesse (Bioform Inc, USA) is a sterile, latex-free, non-pyrogenic, semi-solid, cohesive subdermal, injectable implant, whose principal component is synthetic calcium hydroxylapatite, a biocompatible material with over 20 years of use in medicine. T
Jayne Furlong, also referred to as Jane Furlong, was a New Zealand girl from Auckland who disappeared from a street in Auckland on 26 May 1993 while working in the sex trade. She had been abducted and murdered. Her remains were found south west of Auckland at Sunset Beach, Port Waikato, on 19 May 2012 after being exposed by erosion of a sandbank. They were positively identified by DNA. At the time of her disappearance, Furlong was due to testify as a witness for the prosecution in two separate legal cases - one involving gang members accused of an assault, and the other relating to a businessman charged with brutal attacks on sex workers. Furlongs ex-partner, who reported her missing on 28 May 1993, has refused to speak to police ever since her bodily remains were found. In 2012, after the remains were found, police released a film made in 1993 for the Crimewatch TV-program. The film shows a re-enactment of street scenes at the time Furlong went missing, with her boyfriend playing himself and ...
Disclosed is an orthopedic and dental implant ceramic composition comprising hydroxyapatite and whitlockite. Said composition is prepared by blending 50 to 99.5% by weight of a crystalline hydroxyapatite and 0.5 to 50% by weight of whitlockite, and then, sintering the blend at a temperature of 900 to 1,400 C. Said crystalline hydroxyapatite is prepared by the solid phase reaction wherein a mixture of a calcium phosphate, having a Ca/P ratio of 1.5 to 1.67 by mole, and a stoichiometric amount or more of a calcium compound is heated at a temperature of 500 to 1,000 C. Said calcium compound is at least one compound selected from the group consisting of CaCO3, CaO, Ca(OH)2, CaF2, Ca(COO)2, Ca(NO3)2 and CaCl2.
Systems for targeted delivery of drugs with high affinity for specific organs, tissues, and cells were introduced at the beginning of the twentieth century. Recently, this concept is attracting much attention. These systems have shown most effective in reducing adverse effects of drugs. In recent years, scientists have created a system of nanoparticles for delivery of vitamin D. Special attention is paid to the role of vitamin D in the division and differentiation of osteoblasts and thus, in its role in osteogenesis. In this regard it was interesting to observe the local effects of the active form of vitamin D3 in osteogenesis, as a part of the system for local delivery. These effects were observed on an experimental model. Three types of nanobiomaterial were implanted in the artificially made defects in rats mandibular bone. Six weeks after implantation of hydroxyapatite, hydroxyapatite-coated vitamin D3 and hydroxyapatite nanoparticles coated with vitamin D3 mixed with the polymer, ...the ...
It is observed that good strength results are obtained by the compression to low pressures, what can suggest us that we are in the pressures frontier that causes overpressing in the material after the sintering process.. The proposed polynomial was: Y = b0 + b1X1 + b2X2 + b3X3 + b12X1X2 + b13X1X3 + b23X2X3 + b123X1X2X 3 + b33X32 + b133X1X3 2 + b233X2X3 2. For DTS we thought about quadratic terms of temperature, only variable with three levels, what presupposes their importance in the analysis. The resulting polynomial DTS = 7.2575 - 1.86 p + 6.03375 T + 5.68125 T2 shows the temperature influence, because the linear and quadratic terms are significant to the statistical analysis. Besides, a small inverse influence of the pressure is observed. A slight increment of the DTS exists as the pressure value decreases. The biggest values of DTS were obtained at 1200oC.. For density, the resulting polynomial was r = 1.47375 + 0.2965 T - 0.245 T2 + 0.0655 PT + 0.01625 hT2 - 0.09125 PT2, where the ...
Ethanol is currently the most common liquid fuel derived from biomass in the world, used primarily as a blendstock in gasoline-powered vehicles. In the next 20 years, demand is anticipated to grow in heavier, C8-22 distillate-range fuels such as diesel and jet while that of gasoline is projected to decrease,1 motivating research efforts into the conversion ethanol to heavier fuels.2 Coupling of ethanol via the Guerbet pathway has been examined mainly as a means to produce 1-butanol, which has improved gasoline fuel properties compared to ethanol.3-4 Ethanol coupling beyond 1-butanol is possible, resulting in both linear and branched C6+ alcohols.5-6 The potential of using alcohol coupling to produce distillate-range alcohols from ethanol is largely unknown since coupling beyond 1-butanol is seldom-studied and complicated by several complexities which arise at elevated conversions (,30%). Here we discuss the use of kinetic modeling to understand how inhibition by byproduct water and differences ...
Journal of Nanomaterials is a peer-reviewed, Open Access journal that aims to bring science and applications together on nanoscale and nanostructured materials with emphasis on synthesis, processing, characterization, and applications of materials containing true nanosize dimensions or nanostructures that enable novel/enhanced properties or functions. It is directed at both academic researchers and practicing engineers. Journal of Nanomaterials will highlight the continued growth and new challenges in nanomaterials science, engineering, and nanotechnology, both for application development and for basic research. All papers should emphasize original results relating to experimental, theoretical, computational, and/or applications of nanomaterials ranging from hard (inorganic) materials, through soft (polymeric and biological) materials, to hybrid materials or nanocomposites.
Low prices on Microcrystalline Hydroxyapatite! Beneficial form of supplemental calcium. Microcrystalline calcium hydroxyapatite compound (MCHC) is an extract of young bovine bone. Studies in Britian showed it to be an extremely bioavailable form of calcium that helped prevent bone loss and restore bone mineral content.*
Several tapered stems with similar geometry and extensive hydroxyapatite coating have recently been introduced. It is not clear, however, whether they shar
Adult subcutaneous fat tissue is an abundant source of multipotent cells. Previous studies from our laboratory have shown that, in vitro, adipose-derived adult stem (ADAS) cells express bone marker proteins including alkaline phosphatase, type I collagen, osteopontin, and osteocalcin and produce a mineralized matrix as shown by alizarin red staining. In the current study, the ADAS cell ability to form osteoid in vivo was determined. ADAS cells were isolated from liposuction waste of three individual donors and expanded in vitro before implantation. Equal numbers of cells (3 x 10(6)) were loaded onto either hydroxyapatite/tricalcium phosphate (HA-TCP) cubes or the collagen/HA-TCP composite matrix, Collagraft, and then implanted subcutaneously into SCID mice. After 6 weeks, implants were removed, fixed, and demineralized and sectioned for hematoxylin and eosin staining. Osteoid formation was observed in 80% of HA-TCP implants loaded with ADAS cells. Only 20% of Collagraft implants were positive ...
A bone repair material is described that is of putty-like consistency, particularly useful for repairing dental bony defects such as those caused by bone loss resulting from moderate or severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone-derived or derived from bone-like hydroxyapatite or synthetic hydroxyapatite; and, a resorbable carrier, such as high molecular weight polysaccharides, such as hyaluronic acid. A high concentration of particulate in the putty enhances bone repair and requires a high concentration of carrier to retain the putty at the defect site. For a particulate density of about 1.2 g/cc such as PEPGEN P-15 Bone Graft, a preferred formulation comprises about 55% percent by weight of the putty suspended in a hyaluronic acid gel of about 1.4 x 106 daltons molecular weight and a final concentration of about 56 mg/cc which material
Hydroxyapatite is chemically similar to hard tissues in mammals as well as mineral component of bones. Hydroxyapatite is classed as bioactive - it will support bone ingrowth and Osseo integration when used in orthopedic, dental, and maxillofacial applications.Rising demand for hydroxyapatite, owing to increasing dem...
Calcium, Bone, Bone Regeneration, Hydroxyapatite, Regeneration, Fibroblast, Fibroblast Growth Factor, mRNA, Rabbits, Calcium Hydroxyapatite, Titanium, Teeth, Cell, Alkaline Phosphatase, Basic Fibroblast Growth Factor, Bone Formation, Cell Proliferation, Femurs, Osteoblasts, Osteocalcin
Bone defects due to trauma or disease have led to the need for biomaterials as substitutes for tissue regeneration and repair. Herein, we introduce a porous triphasic ceramic-coated hydroxyapatite scaffold (HASi) for such applications. Interestingly, in the degradation experiments with isotonic buffer, HASi showed a significant release of silica with the disappearance of the tricalcium phosphate phase. Furthermore, the material also exhibited cytocompatibility with cultured bone marrow-derived mesenchymal stem cells of human origin. The material chemistry, together with the favorable cellular characteristics, indicates HASi as a promising candidate for critical-size bony defects, which still remains a formidable clinical challenge in the orthopedic scenario.
In this study, we describe a sensitive protocol for the detection of bladder cancer cells in a patients urine without pre-treatment of the urine sample using antibody-modified hydroxyapatite (HAp) micro/nanostructured surfaces converted from natural seashells under mild biomineralization conditions. The mec
The response of human bone marrow cell to bone ash-derived hydroxyapatite (HA) and tuna bonederived HA powders was compared. HA ceramics were prepared from the commercial..
Specialized manufacturer and supplier of synthetic nano-hydroxyapatite and tricalcium phosphate materials marketed as nanoXIM, used to manufacture medical devices, oral care and food products.
Specialized manufacturer and supplier of synthetic nano-hydroxyapatite and tricalcium phosphate materials marketed as nanoXIM, used to manufacture medical devices, oral care and food products.
Microcrystalline Calcium Hydroxyapatite Compound, or MCHC, is actually a bone-setting up supplement with that may have excellent absorption in comparison to calcium. As it contains every one of the minerals The natural way transpiring in healthy bone in the proper proportions, combined with the other Energetic and supportive constituents of bone, MCHC makes an extensive bone aid complement. Calcium is often a mineral involved with many different features of your body, and MCHC is a concentrate of entire bone. As a result, MCHC consists of calcium, but calcium is only one of a number of factors needed to help build and retain strong bones ...
Microcrystalline Calcium Hydroxyapatite Compound, or MCHC, can be a "bone-developing" supplement with which will have excellent absorption in comparison to calcium. Mainly because it is made up of all the minerals In a natural way happening in healthy bone in the ideal proportions, together with the other active and supportive constituents of bone, MCHC can make an extensive bone assistance nutritional supplement. Calcium is usually a mineral involved in a number of capabilities of the body, and MCHC is often a focus of full bone. As such, MCHC is made up of calcium, but calcium is just one of a variety of components necessary to assist build and keep powerful bones ...
It enables the quantitative determination of bone mineral content of the lumbar spine in mg/ml of calcium hydroxyapatite for the diagnosis and follow-up of osteoporosis with CT. The patient is scanned together with the water- and bone-equivalent reference phantom.. Capabilities include:. ...
Answer: Deposition of calcium (hydroxyapatite) in the epithelial basement mermbrane, Bowmans layer, and superficial stroma. Generally the factors leading to calcium deposition are the concentration of calcium in the tear film and the soluability, which is related to the phosphorus concentration and the pH ...
MMP-2, MMP-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapatite particles.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
HA Ultrogel® is a composite material of cross-linked agarose and microcrystalline hydroxyapatite enclosed in the agarose matrix. The material shows mixed mode functionality based on cation exchange and metal affinity in the hydroxyapatite structure. A wide variety of applications include separation of proteins, peptides and nucleic acids, from laboratory to production scale.
A 1964 Volkswagen Beetle measures 0.02028 furlongs. As the longest continuously-produced automobile design - in production for 75 years between 1938 and 2003 - the Beetle was voted the most fourth-most influential car of the twentieth century by the Global Automotive Elections Foundation. ...
Frederick Thomas Furlong: current contact information and listing of economic research of this author provided by RePEc/IDEAS
McAlees, E., Vollebregt, P. F., Stevens, N., Dudding, T. C., Emmanuel, A. V., Furlong, P. L., Hamdy, S., Hooper, R. L., Jones, J. F. X., Norton, C., OConnell, P. R., Scott, S. M. & Knowles, C. H., 26 Jun 2018, In : Trials. 19, 1, 336.. Research output: Contribution to journal › Article ...
Troubled actor Edward Furlong exposed his 6-year-old son to cocaine and should NOT be allowed to be near the child without strict supervision ... this…
Troubled actor Edward Furlong exposed his 6-year-old son to cocaine and should NOT be allowed to be near the child without strict supervision ... this…
Since the 1980s, hydroxyapatite (Ca10(PO4)6(OH)2; HA) has been used as a coating material for orthopaedic implant applications owing to its bioactivity and similarity in composition to bone mineral (Constantz et al. 1995). It was found to be capable of supporting bone ingrowth and osseointegration (Hench 1998). Therefore, it had significant success in strengthening the fixation between the implant and bone tissue, thus reducing the healing period during orthopaedic implantation practice (Oonishi 1991).. However, in addition to surface chemistry, a number of studies have shown that the surface topography can be another significant factor in influencing the initial cellular response and therefore subsequent bone tissue regeneration (Curtis & Wilkinson 1997). The work of Britland et al. (1996) compared a chemical cue (laminin) oriented at right angles with a topographic factor. When the grooves were ,500 nm deep, the cells reacted mainly with the chemical cue. When deeper grooves were present, the ...
Ceramic Hydroxyapatite XT, a calcium affinity cation exchange chromatography media, provides single-step clearance of impurities and aggregates...
TY - JOUR. T1 - Thermal effects of carbonated hydroxyapatite modified by glycine and albumin. AU - Gerk, S. A.. AU - Golovanova, O. A.. AU - Kuimova, M. V.. PY - 2017/2/7. Y1 - 2017/2/7. N2 - In this work calcium phosphate powders were obtained by precipitation method from simulated solutions of synovial fluid containing glycine and albumin. X-ray diffraction and IR spectroscopy determined that all samples are single-phase and are presented by carbonate containing hydroxyapatite (CHA). The thermograms of solid phases of CHA were obtained and analyzed; five stages of transformation in the temperature range of 25-1000°C were marked. It is shown that in this temperature range dehydration, decarboxylation and thermal degradation of amino acid and protein connected to the surface of solid phase occur. The tendency of temperature lowering of the decomposition of powders synthesized from a medium containing organic substances was determined. Results demonstrate a direct dependence between the ...
We consider a stack of weakly Josephson coupled superfluid layers with c-axis disorder in the form of random superfluid stiffnesses and vortex fugacities in each layer as well as random interlayer coupling strengths. In the absence of disorder this system has a 3D XY type superfluid-normal phase transition as a function of temperature. We develop a functional renormalization group to treat the effects of disorder, and demonstrate that the disorder results in the smearing of the superfluid-normal phase transition via the formation of a Griffiths phase. Remarkably, in the Griffiths phase, the emergent power-law distribution of the interlayer couplings gives rise to a sliding Griffiths superfluid, with a finite stiffness in the a-b direction along the layers, and a vanishing stiffness perpendicular to it. ...
A process for preparing a nanocrystalline material comprising at least a first ion and at least a second ion different from the first ion, and wherein at least the first ion is a metal ion, is described. The process comprises contacting a metal complex comprising the first ion and the second ion with a dispersing medium suitable to form the nanocrystalline material and wherein the dispersing medium is at a temperature to allow formation by pyrolysis of the nanocrystalline material when contacted with the metal complex.
Synthesis of Bioactive HEMA-MPS-CaCl2 Hybrid Gels: Effects of Catalysts in the Sol-Gel Processing on Mechanical Properties and in vitro Hydroxyapatite Formation in a Simulated Body ...
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis ...
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Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107 ...
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